Alicia R. Folgueras, Fernando Martín de Lara, Alberto M. Pendás, Cecilia Garabaya, Francisco Rodríguez, Aurora Astudillo, Teresa Bernal, Rubén Cabanillas, Carlos López‐Otín, Gloria Velasco,
Abstract Proteolytic events at the cell surface are essential in the regulation of signal transduction pathways. During the past years, the family of type II transmembrane serine proteases (TTSPs) has acquired an increasing relevance because of their privileged localization at the cell surface, although our current understanding of the biologic function of most TTSPs is limited. Here we show that matriptase-2 (Tmprss6), a recently described member of the TTSP family, is an essential regulator of iron ...
Tópico(s): Erythrocyte Function and Pathophysiology
2008 - Elsevier BV | Blood