António S. Barros, Rui Pinto, Delphine Jouan‐Rimbaud Bouveresse, Douglas N. Rutledge,
Outer product analysis is a method that permits the combination of two spectral domains with the aim of emphasizing co-evolutions of spectral regions. This data fusion technique consists in the product of all combinations of the variables that define each spectral domain. The main issue concerning the application of this technique is the very wide data matrix obtained which can be very hard to handle with multivariate techniques such as PCA or PLS, due to computer resources constraints. The present ...
Tópico(s): Neural Networks and Applications
2008 - Elsevier BV | Chemometrics and Intelligent Laboratory Systems
Produção Nacional
Revisado por pares
Sarah M.L. Xavier, Cindy Barbosa, D.O. Barros, Rui F. M. Silva, Aline A. Oliveira, Rivelilson Mendes de Freitas,
Vitamin C (VIT C) is an exogenous antioxidant able to alter the brain oxidative stress. Antioxidant properties have been showed in seizures and status epilepticus (SE) induced by pilocarpine in adult rats. This present study was aimed at was investigating the VIT C effects on latency to first seizure, in percentage of seizures, mortality rate, as well as hippocampal lipid peroxidation levels and catalase activity after seizures and SE. The VIT C effects were investigated after the pretreatment with ...
Tópico(s): Medicinal Plants and Neuroprotection
2007 - Elsevier BV | Neuroscience Letters
Madeleine Ramstedt, Isabel Ribeiro, Helena Bujdáková, Filipe J. Mergulhão, Luísa Jordão, Peter Thomsen, Martin Alm, Mette Burmølle, T. Vladkova, Füsun Can, Meital Reches, Martijn Riool, Alexandre A. Barros, Rui L. Reis, Emilio Meaurio, Judith Kikhney, Annette Moter, Sebastian A. J. Zaat, Jelmer Sjollema,
Abstract In Europe, the mean incidence of urinary tract infections in intensive care units is 1.1 per 1000 patient‐days. Of these cases, catheter‐associated urinary tract infections (CAUTI) account for 98%. In total, CAUTI in hospitals is estimated to give additional health‐care costs of £1–2.5 billion in the United Kingdom alone. This is in sharp contrast to the low cost of urinary catheters and emphasizes the need for innovative products that reduce the incidence rate of CAUTI. Ureteral stents and ...
Tópico(s): Ureteral procedures and complications
2019 - Wiley | Macromolecular Bioscience
Diogo Guedes Vidal, Nelson Barros, Rui Leandro Maia,
Tópico(s): Urban Agriculture and Sustainability
2020 - Springer International Publishing | Encyclopedia of the UN sustainable development goals
Isabel C.F.R. Ferreira, Lillian Barros, Rui M.V. Abreu,
Maintenance of equilibrium between free radical production and antioxidant defences (enzymatic and non enzymatic) is an essential condition for normal organism functioning. When this equilibrium has a tendency for the production of free radicals we say that the organism is in oxidative stress. In this situation, excess free radicals may damage cellular lipids, proteins and DNA, affecting normal function and leading to various diseases. In aerobic organisms, the free radicals are constantly produced ...
Tópico(s): Phytochemicals and Antioxidant Activities
2009 - Bentham Science Publishers | Current Medicinal Chemistry
Pedro Rodrigues, José A. Rodrigues, Aquiles A. Barros, Rui A. S. Lapa, José L. F. C. Lima, J. M. Machado Cruz, A. A. Ferreira,
Diacetyl can be determined by adsorptive stripping voltammetry after derivatization with o-phenylenediamine. The method may be applicable to the determination of diacetyl in different foods, being a good alternative to other analytical methods. In this work an on-line automated analytical system for diacetyl determination in beer is described. A hanging mercury drop electrode voltammetric flow detector was used, and the analyte was determined without the traditional deoxygenation procedure. The ...
Tópico(s): Meat and Animal Product Quality
2002 - American Chemical Society | Journal of Agricultural and Food Chemistry
Marta M. Andrade, M. Teresa Barros, Rui C. Pinto,
Microwave irradiation allows increasing the speed of several reactions and also offers the possibility of eliminating poisoning organic solvents. In this work we report the microwave-assisted neat synthesis of α-phenyl-tert-butylnitrone (PBN) and other alkyl and aryl nitrones and also the rapid synthesis of isoxazolidines resulting from 1,3-dipolar cycloaddition of nitrones to ethyl trans-crotonate.
Tópico(s): Chemical Synthesis and Reactions
2008 - Elsevier BV | Tetrahedron
Sérgio F. Salvador, Joana Oliveira, Josué Pereira, Henrique Barros, Ruí Vaz,
Endoscopic third ventriculostomy (ETV) is the treatment of choice for obstructive hydrocephalus, but the outcome is still controversial in terms of age and aetiology. Between 1998 and 2011, 168 consecutive procedures were performed in 164 patients, primarily children (56% < 18 years of age and 35% < 2 years of age). The causes of obstructive hydrocephalus included tumoural pathology, Chiari malformation, congenital obstruction of the aqueduct, post-infectious and post-haemorrhagic membranes, and ventriculo- ...
Tópico(s): Fetal and Pediatric Neurological Disorders
2014 - Elsevier BV | Clinical Neurology and Neurosurgery
André Barros, Rui Baptista, Antony Nogueira, Elisabete Jorge, Rogério Teixeira, Graça Castro, Pedro Monteiro, Luís A. Providência,
Pulmonary embolism (PE) is a common cardiovascular emergency that, when combined with chronic thromboembolic pulmonary hypertension (PH), is associated with high mortality and morbidity. We aimed to determine the incidence of and predisposing factors for the development of PH after a PE episode.A retrospective study was conducted in 213 patients admitted to an intensive care unit with intermediate-to-high risk PE between 2000 and 2010. Clinical data at admission were collected and the incidence of ...
Tópico(s): Cardiovascular Effects of Exercise
2013 - Elsevier BV | Revista Portuguesa de Cardiologia
Teresa M.V.R. de Barros, Rui C. Santos, Anabela C. Fernandes, Manuel E. Minas da Piedade,
The accuracy and precision of a Setaram DSC 121 for the measurement of heat capacities of solids in the continuous mode was tested using sapphire and benzoic acid. The influence of the heating rate, mass of sample, and position of the crucible in the measuring tube on the obtained results is discussed. In the temperature range studied (320–440 K for sapphire and 320–370 K for benzoic acid) the accuracy and precision of the determination, based on the average results of three independent experiments, ...
Tópico(s): Thermal and Kinetic Analysis
1995 - Elsevier BV | Thermochimica Acta
Produção Nacional
Revisado por pares
Chun Hung Lui, Zhipeng Ye, Courtney Keiser, Eduardo B. Barros, Rui He,
We observe distinct interlayer shear mode Raman spectra for trilayer graphene with ABA and ABC stacking order. There are two rigid-plane shear-mode phonon branches in trilayer graphene. We find that ABA trilayers exhibit pronounced Raman response from the high-frequency shear branch, without any noticeable response from the low-frequency branch. In contrast, ABC trilayers exhibit no response from the high-frequency shear branch, but significant Raman response from the low-frequency branch. Such ...
Tópico(s): Mechanical and Optical Resonators
2015 - American Institute of Physics | Applied Physics Letters
Àngels Bayés, Albert Samà, Anna Prats, Carlos Pérez‐López, M. Cruz Crespo, Juan Manuel Moreno, Sheila Alcaine, Alejandro Rodríguez‐Molinero, Berta Mestre, Paola Quispe, Ana Correia de Barros, Rui Sarmento e Castro, Alberto Costa, Roberta Annicchiarico, Patrick Browne, Tim Counihan, Hadas Lewy, Gabriel Vainstein, Leo R. Quinlan, Dean Sweeney, Gearóid ÓLaighin, Jordi Rovira, Daniel Rodrigue z-Martin, Joan Cabestany,
The treatment of Parkinson's disease (PD) with levodopa is very effective. However, over time, motor complications (MCs) appear, restricting the patient from leading a normal life. One of the most disabling MCs is ON-OFF fluctuations. Gathering accurate information about the clinical status of the patient is essential for planning treatment and assessing its effect. Systems such as the REMPARK system, capable of accurately and reliably monitoring ON-OFF fluctuations, are of great interest. To analyze ...
Tópico(s): Voice and Speech Disorders
2017 - Elsevier BV | Gait & Posture
Diogo Guedes Vidal, Cláudia Oliveira Fernandes, Lilian Monteiro Ferrari Viterbo, Helena Vilaça, Nelson Barros, Rui Leandro Maia,
The complex interaction of ecological and social systems has shaped the cities through the time. This fosters the need to develop interdisciplinary approaches to urban issues by combining natural and social sciences. Cities, as the predominant mode of social organization, are vulnerable to social and environmental challenges which urban green spaces (UGS) can contribute to solve by the ecosystem services (ES) that can provide. The objective was to assess the quality of UGS framed by the ES classification ...
Tópico(s): Urban Agriculture and Sustainability
2020 - Taylor & Francis | International Journal of Sustainable Development & World Ecology
Isa Santos, Henrique G. Colaço, Ana Neves‐Costa, Elsa Seixas, Tiago R. Velho, Dora Pedroso, André Barros, Rui Martins, Nuno Carvalho, Didier Payen, Sebastian Weis, Hyon‐Seung Yi, Minho Shong, Luís F. Moita,
Significance Sepsis remains a leading cause of death. New insights into its pathophysiology are likely to be key to the development of effective therapeutic strategies against sepsis. Given the role of GDF15 in metabolism regulation and in cachexia during late stages of cancer, features that also occur in sepsis, elucidation of the possible mechanistic role of GDF15 in sepsis is of great importance. We find that septic patients have very high levels of GDF15 in the peripheral blood, which correlate ...
Tópico(s): Macrophage Migration Inhibitory Factor
2020 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Diogo Guedes Vidal, Ricardo Cunha Dias, Catarina Patoilo Teixeira, Cláudia Oliveira Fernandes, Walter Leal Filho, Nelson Barros, Rui Leandro Maia,
Public Urban Green Spaces (PUGS) are the main drivers for increasing the quality of urban environments, potentiating local resilience, promoting sustainable lifestyles, as well as improving both the health and well-being of their users. Municipal leaders are responsible for the maintenance of PUGS. However, current evidence identifies limited knowledge about urban green infrastructure governance since the lack of data about PUGS is the main obstacle to effective intervention. Set against this background, ...
Tópico(s): Urban Agriculture and Sustainability
2022 - Elsevier BV | Environmental Science & Policy
Diogo Guedes Vidal, Catarina Patoilo Teixeira, Cláudia Oliveira Fernandes, Agnieszka Olszewska-Guizzo, Ricardo Cunha Dias, Helena Vilaça, Nelson Barros, Rui Leandro Maia,
Public urban green spaces (PUGS) play a vital role in the dense urban fabric as places of Nature-Society contact and socialization. Despite some advances in the field, the relationship between the PUGS surroundings and their users' behaviours remains unclear. This study examined the patterns of human behaviour in four PUGS of the city of Porto, on the north Portuguese coast, where the behavioural mapping method was applied. Observational data regarding 979 PUGS users' socio-demographics and behaviours ...
Tópico(s): Urban Agriculture and Sustainability
2022 - Elsevier BV | Urban forestry & urban greening
M. Margarida Cardoso, Inês N. Peça, Cláudia D. Raposo, Krasimira T. Petrova, M. Teresa Barros, Rui Gardner, A. Bicho,
The objective of this work is to produce doxorubicin-loaded galactose-conjugated poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs) to be specifically recognised by human hepatoma cellular carcinoma (Hep G2) cells and assess NPs cytotoxicity. Doxorubicin-unloaded and doxorubicin-loaded galactose-conjugated PLGA NPs were prepared using an emulsion method and characterised for morphology, size, drug release behaviour, Hep G2 recognition and cell cytotoxicity. The produced doxorubicin-loaded PLGA- ...
Tópico(s): Advanced Drug Delivery Systems
2016 - Taylor & Francis | Journal of Microencapsulation
Marina Prieto Afonso Lencastre, Diogo Guedes Vidal, Rui Estrada, Nelson Barros, Rui Leandro Maia, Paulo Farinha-Marques,
This paper considers the relationship between biophilia and well-being in a sample of users of urban green spaces in the city of Porto (Portugal) as a case study. The biophilia hypothesis is explored through the responses of 131 participants in a survey. Users of urban green spaces valued their provision of quiet and shade, with a high diversity of plant species and tranquillity. The survey also found that being satisfied with urban green spaces enhances self-perceived health status, which means ...
Tópico(s): Urban Agriculture and Sustainability
2022 - Taylor & Francis | International Journal of Environmental Studies
Maria João Rodrigues, Viana Castañeda-Loaiza, Ivo Monteiro, José Pinela, Lillian Barros, Rui M.V. Abreu, M. Conceição Oliveira, Catarina Pinto Reis, Florbela Soares, Pedro Pousão‐Ferreira, Catarina Pereira, Luísa Custódio,
Water extracts from sea lavender (Limonium algarvense Erben) plants cultivated in greenhouse conditions and irrigated with freshwater and saline aquaculture effluents were evaluated for metabolomics by liquid chromatography-tandem high-resolution mass spectrometry (LC-HRMS/MS), and functional properties by in vitro and ex vivo methods. In vitro antioxidant methods included radical scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), ferric- ...
Tópico(s): melanin and skin pigmentation
2021 - Multidisciplinary Digital Publishing Institute | Foods
J. Pinto da Costa, Rute Pereira, Jorge Oliveira, Ângela Alves, Ângela Marques-Magalhães, Amaro Frutuoso, Carla Leal, Nuno Barros, Rui Fernandes, Diogo Queiroz Almeida, Márcia Barreiro, Alberto Barros, Mário Sousa, Rosália Sá,
The human oocyte zona pellucida (ZP) is made of four glycoproteins, ZP1-ZP4. Recently, the prostate adenocarcinoma and prostate cancer PC3 cell-line were shown to express the human oocyte ZP3 glycoprotein, which was evaluated in a single report subject to patent. To further clarify whether oocyte zona pellucida glycoproteins are expressed in prostate cancer tissue and PC3-cells, in this report we evaluated protein expression of the four ZP glycoproteins in normal prostate tissue, prostate adenocarcinoma ...
Tópico(s): Sperm and Testicular Function
2018 - Elsevier BV | Tissue and Cell
Arash Nickkholgh, Miriam Barro-Bejarano, Rui Liang, Markus Zorn, Arianeb Mehrabi, Martha‐Maria Gebhard, Markus W. Büchler, Carsten N. Gutt, Peter Schemmer,
Tópico(s): Liver Disease and Transplantation
2007 - Springer Science+Business Media | Surgical Endoscopy
Peter de Barros Damgaard, Rui Martiniano, Jack Kamm, J. Víctor Moreno-Mayar, Guus Kroonen, Michaël Peyrot, Gojko Barjamovic, Simon Rasmussen, Claus M. Zacho, Nurbol Baimukhanov, Victor F. Zaibert, Victor Merz, Arjun Biddanda, Ilja Merz, Valeriy Loman, Valeriy Evdokimov, Emma Usmanova, Brian Hemphill, Andaine Seguin‐Orlando, Fulya Eylem Yediay, Inam Ullah, Karl-Göran Sjögren, Katrine Højholt Iversen, Jérémy Choin, Constanza de la Fuente, Melissa Ilardo, Hannes Schroeder, Vyacheslav Moiseyev, Andrey Gromov, Andrei Polyakov, Sachihiro Omura, S. Yücel Şenyurt, Habib Ahmad, Catriona J. McKenzie, Ashot Margaryan, Abdul Hameed, Abdul Samad, Nazish Gul, Muhammad Hassan Khokhar, Olga I. Goriunova, Vladimir I. Bazaliiskii, John Novembre, Andrzej Weber, Ludovic Orlando, Morten E. Allentoft, Rasmus Nielsen, Kristian Kristiansen, Martin Sikora, Alan K. Outram, Richard Durbin, Eske Willerslev,
The Yamnaya expansions from the western steppe into Europe and Asia during the Early Bronze Age (~3000 BCE) are believed to have brought with them Indo-European languages and possibly horse husbandry. We analyzed 74 ancient whole-genome sequences from across Inner Asia and Anatolia and show that the Botai people associated with the earliest horse husbandry derived from a hunter-gatherer population deeply diverged from the Yamnaya. Our results also suggest distinct migrations bringing West Eurasian ...
Tópico(s): Yersinia bacterium, plague, ectoparasites research
2018 - American Association for the Advancement of Science | Science
Diogo Libânio, V. Braga, Sílvia de Barros Ferraz, Rui Castro, Jorge Lage, Inês Pita, Cátia Ribeiro, Joaquim Abreu de Sousa, Mário Dinis‐Ribeiro, Pedro Pimentel‐Nunes,
Abstract Background There are no prospective studies comparing endoscopic submucosal dissection (ESD) and gastrectomy, especially evaluating patient-reported outcomes. Our aim was to compare the safety and impact on quality of life (QoL) of ESD and gastrectomy in patients with early gastric neoplasia. Methods This prospective study included consecutive patients presenting with early gastric neoplasia in a tertiary center from January 2015 to August 2016. Data collection included curative resection, ...
Tópico(s): Esophageal and GI Pathology
2018 - Thieme Medical Publishers (Germany) | Endoscopy
Produção Nacional
Revisado por pares
Hugo Abensur, I Nussenzveig, Luís Balthazar Saldanha, M.S.C. Petalozzi, Myrthes Toledo Barros, M Marcondes, Rui Toledo Barros,
Schistosomal nephropathy has long been related to the hepatosplenic form of schistosomiasis. In the last few years, 24 patients with hepatointestinal schistosomiasis and the nephrotic syndrome were studied. Aiming at evaluating a possible etiologic participation of schistosomiasis in the development of the nephropathy, this group was comparatively studied with a group of 37 patients with idiopathic nephrotic syndrome. Both groups had a different distribution of the histologic lesions. In the group ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
1992 - UNIVERSIDADE DE SÃO PAULO | Revista do Instituto de Medicina Tropical de São Paulo
S.V. Silva, Rui Barros, F. Xavier Malcata,
ABSTRACT: Polyacrylamide gel electrophoresis (in the presence of urea) and gel permeation chromatography were employed to assess the profile of hydrolysis of caseins and the activity of enzymes contributed by the flowers of the plant Cynara cardunculus on bovine caseins, after previous precipitation with ammonium sulfate or in a plain crude aqueous extract. Results indicated that the qualitative degradation profile of bovine caseins by plant enzymes (cardosins) remains essentially unchanged upon extraction, ...
Tópico(s): Coenzyme Q10 studies and effects
2002 - Wiley | Journal of Food Science
Rui Barros, F. Xavier Malcata,
The purpose of this research work was to study the proteolytic activity of aqueous crude extracts of flowers of the plant Cynara cardunculus on the major whey proteins, namely, β-lactoglobulin (β-Lg) and α-lactalbumin (α-La). These extracts, containing a mixture of cardosins A and B (i.e., two distinct aspartic proteases), have been employed for many years in traditional cheese-making in Portugal and Spain. Cow's milk sweet whey was incubated for up to 24 h at various ratios of addition of crude enzyme ...
Tópico(s): Agricultural safety and regulations
2002 - American Chemical Society | Journal of Agricultural and Food Chemistry
Rui Barros, Clara I Extremina, Inês C. Gonçalves, Beatriz O Braga, Victor M. Balcão, F. Xavier Malcata,
In the present research effort, production of derivatives of cardosin A (a plant protease) encompassing full stabilization of its dimeric structure has been achieved, via covalent, multi-subunit immobilization onto highly activated agarose-glutaraldehyde supports. Boiling such enzyme derivatives in the presence of sodium dodecyl sulfate and β-mercaptoethanol did not lead to leaching of enzyme, thus providing evidence for the effectiveness of the attachment procedure. Furthermore, the cardosin A derivatives ...
Tópico(s): Enzyme Catalysis and Immobilization
2003 - Elsevier BV | Enzyme and Microbial Technology
Gonçalo Almeida, Alexandre Luiz Bezerra Figueiredo, Marta Rôla, Rui Barros, Paul Gibbs, Tim Hogg, Paula Teixeira,
Seventy raw milk cheeses made in different regions of Portugal, both hard and soft varieties, made with cow's, ewe's, or goat's milk or combinations of these, were sampled within their quoted shelf lives for microbiological safety. On the basis of the presence or numbers of Escherichia coli, E. coli O157, Staphylococcus aureus, Salmonella, and Listeria monocytogenes, cheeses were categorized as satisfactory, acceptable, unsatisfactory, or unacceptable and potentially hazardous. Twenty-two of the ...
Tópico(s): Salmonella and Campylobacter epidemiology
2007 - Elsevier BV | Journal of Food Protection
José Sena-Cruz, Joaquim A. O. Barros, Mário Rui Freitas Coelho, Luís F. F. T. Silva,
Tópico(s): Concrete Corrosion and Durability
2011 - Elsevier BV | Construction and Building Materials
Rui Barros, F. Xavier Malcata,
Crude mixtures of aspartic proteases from flowers of the plant Cynara cardunculus have been studied frequently, as have activities of such enzymes (in pure form) on caseins from bovine, ovine, and caprine sources. This research study addressed pure bovine whey protein as substrates; that is, α-lactalbumin (αLA) and β-lactoglobulin (α-LG), submitted to hydrolysis by 1 of 2 aspartic proteases (cardosins A and B), previously extracted and purified from C. cardunculus. Samples collected, following incubation ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2006 - Elsevier BV | Journal of Dairy Science