Catarina Pinto Reis, Isabel Vitória Figueiredo, Rui A. Carvalho, John G. Jones, Patrícia M. Nunes, Ana F. Soares, Cristina Ferreira Silva, António J. Ribeiro, Francisco Veiga, Christiane Damgé, António Cabrita, Ronald J. Neufeld,
Subacute toxicological assessment on diabetic rats was conducted after 15 days of daily oral administration of nanoparticulate insulin. Haematological and biochemical analyses were conducted on blood and urine, biopsies performed on organs and tissues, and histology analysed by optical microscopy. Insulin-loaded nanoparticles alone did not change liver or kidney functions. The increase of some hepatic parameters was attributed to diabetes physiopathology and to chemical inducement of diabetes and ...
Tópico(s): Pancreatic function and diabetes
2008 - Taylor & Francis | Nanotoxicology
Produção Nacional
Revisado por pares
Cristiane Grella Miranda, Priscila Dayane de Freitas Santos, Jéssica Thaís do Prado Silva, Fernanda Vitória Leimann, Bianca Ferreira Borges, Rui M.V. Abreu, Rafael Porto Ineu, Odinei Hess Gonçalves,
Lutein is a bioactive found in dark leafy vegetables that may be used as a nutraceutical agent in foodstuff and an inhibitor of key enzymes of the human body such as those involved in the cholinergic system. However, its high hydrophobicity leads to low bioavailability and must be overcome if lutein is to be added in foods. The objective of this study was to evaluate the influence of nanoencapsulated lutein in the activity of the acetylcholinesterase enzyme. The in vitro study was carried out using ...
Tópico(s): Proteins in Food Systems
2019 - Elsevier BV | Food Chemistry
Camile B. Woitiski, Ronald J. Neufeld, Ana F. Soares, Isabel Vitória Figueiredo, Francisco Veiga, Rui A. Carvalho,
Nanoparticles were designed to promote insulin intestinal absorption via the oral route, to increase portal insulin levels to better mimic the physiological pathway, providing enhanced glucose control through glycogenolysis and gluconeogenesis. Nanoparticles were formulated with insulin encapsulated in the core material consisting of alginate and dextran sulfate, associated with poloxamer and subsequently coated with chitosan then albumin. A spherical and slightly rough core was observed in electron ...
Tópico(s): Pancreatic function and diabetes
2012 - Taylor & Francis | Drug Development and Industrial Pharmacy
Camile B. Woitiski, Ronald J. Neufeld, Francisco Veiga, Rui A. Carvalho, Isabel Vitória Figueiredo,
Intestinal uptake, insulinemia and hypoglycemic effect of orally delivered insulin encapsulated in polyelectrolytically stable nanoparticles were evaluated in streptozotocin-induced Wistar diabetic rats. Nanoparticles with 396 nm mean diameter were formed by alginate and dextran sulfate nucleating around calcium and binding to poloxamer, stabilized by chitosan, and subsequently coated with albumin. The resulting negatively charged nanoparticles retained insulin bioactivity and enhanced pharmacological ...
Tópico(s): Nanoparticle-Based Drug Delivery
2010 - Elsevier BV | European Journal of Pharmaceutical Sciences
Vitória Albuquerque, Ana Oliveira, Jorge Lourenço Barbosa, Rui Rodrigues, Francisco Andrade, Miguel Sales Dias, João C. Ferreira,
Transportation data in a smart city environment is increasingly becoming available. This data availability allows building smart solutions that are viewed as meaningful by both city residents and city management authorities. Our research work was based on Lisbon mobility data available through the local municipality, where we integrated and cleaned different data sources and applied a CRISP-DM approach using Python. We focused on mobility problems and interdependence and cascading-effect solutions ...
Tópico(s): Human Mobility and Location-Based Analysis
2021 - Multidisciplinary Digital Publishing Institute | Energies
Produção Nacional
Revisado por pares
Silvana Pinotti Muller, Viviane Aline Oliveira Silva, Ana Vitória Pupo Silvestrini, Luana Henrique de Macedo, Guilherme Ferreira Caetano, Rui Manuel Reis, Maurício V. Mazzi,
Crotoxin (CTX), a heterodimeric phospholipase present in venom of snakes of the genus Crotalus, has demonstrated a broad spectrum of pharmacological properties, such as antimicrobial, hemostatic, and antitumoral. However, the precise mechanism of its cytotoxicity and antitumoral properties remains to be determined. Therefore, in the present study, we isolated crotoxin (F1 CTX) through two steps DEAE-Sepharose and Heparin-Sepharose FF chromatography. The C-terminal sequence of the A- and B-chain protein ...
Tópico(s): Cell death mechanisms and regulation
2018 - Elsevier BV | Toxicon
Vitòria Pereira, Ana Marques, Isabel Gaivão, Andreia Rego, Helena Abreu, Rui Pereira, Maria Ana Santos, Sofia Guilherme, Mário Pacheco,
DNA integrity and stability are essential to organisms' health and survival. However, it has been neglected in what concerns to fish farming, disregarding the potential impact of endogenous/ exogenous factors. As marine macroalgae constitute a source of natural compounds with a large spectrum of biological activities, this study, situated in the interface of nutritional-genetic research and development of algae practical applications, aimed to evaluate the genoprotective properties of a macroalgae- ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2019 - Elsevier BV | Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology
... doi.org/10.3390/insects12040310João Silvestre, Sílvia Pires, Vitória Pereira, Miguel Colaço, Ana Costa, Amadeu Soares, Domitília Matias, Filipa Bettencourt, Sergio Fernández-Boo, Rui Rocha, Andreia Rodrigues Meeting the Salinity Requirements of ...
Tópico(s): Sports Performance and Training
2001 - University of Chicago Press | The American Naturalist
Raymond B. Huey, David Berrigan,
... doi.org/10.3390/insects12040310João Silvestre, Sílvia Pires, Vitória Pereira, Miguel Colaço, Ana Costa, Amadeu Soares, Domitília Matias, Filipa Bettencourt, Sergio Fernández-Boo, Rui Rocha, Andreia Rodrigues Meeting the Salinity Requirements of ...
Tópico(s): Evolution and Genetic Dynamics
2001 - University of Chicago Press | The American Naturalist
Miguel Pinto, João Rodrigues, Rui Matias, Ivone Água‐Doce, Dora Cordeiro, Cristina Belo Correia, João Paulo Gomes, Maria José Borrego, Filipa Alegria, Ana Jacinta Piedade, Maria Beatriz Tomaz, Cristina Toscano, Mariana Pessanha, Eliana Costa, Agostinho Lira, Catarina Chaves, Ana Cristina Simões e Silva, Margarida Pinto, Manuela Ribeiro, Angélica Ramos, Hugo Cruz, Maria Helena Ramos, José Melo‐Cristino, Maria Inês Stilwell, Carlos Marques, Mariana Garcez, M. J. A. PEREIRA, Vera P. Santos, Marco Amaral, Maria José Rego de Sousa, Maria Favila Menezes, Elsa Calado, Luís Dias, Florbela Pereira, Idalina Rocha, Paula Mota Vieira, Maria Alberta Faustino, Maria Carmen Iglesias, R Pinto, L.A. de Francisco Serpa, Adriana Coutinho, Filomena Caldeira, José Diogo, Luísa Sancho, Sandra Schäfer, José Carlos Camisão, Graça Trigueiro, Alexandra Costa, Alda Campos, Alexandra Pereira, Ana Catarina Guerreiro, Gizela Santos, Mónica Cardoso, Filomena Lencastre, Luísa Frazão, Sofia Soares, Inês Figueiredo, Vitória Eduarda Silva Rodrigues, Eugénio Corrêa, Rui Campainha, Maria Rosário Barros, Sofia Botelho Moniz,
Tópico(s): Syphilis Diagnosis and Treatment
2020 - Springer Science+Business Media | European Journal of Clinical Microbiology & Infectious Diseases
Produção Nacional
Kaio F. Vitzel, Marco Aurélio Salomão Fortes, Gabriel Nasri Marzuca-Nassr, Maria Vitória Martins Scervino, Carlos Hermano Pinheiro, Leonardo R. Silveira, Rui Curi,
Skeletal muscle electrical stimulation is commonly used for clinical purposes, assisting recovery, preservation, or even improvement of muscle mass and function in healthy and pathological conditions. Additionally, it is a useful research tool for evaluation of skeletal muscle contractile function. It may be applied in vitro, using cell culture or isolated fibers/muscles, and in vivo, using human subjects or animal models (neuromuscular electrical stimulation - NMES). This chapter focuses on the electrical ...
Tópico(s): Neuroscience and Neural Engineering
2018 - Springer Science+Business Media | Methods in molecular biology
Produção Nacional
Revisado por pares
Arménio Rego, Andreia Vitória, Antônio Caubi Ribeiro Tupinambá, Dálcio Roberto dos Reis, Dálcio Roberto dos Reis, Miguel Piña e Cunha, Rui Lourenço-Gil,
Purpose The purpose of this paper is to explore the Brazilian managers’ attitudes toward older workers, and how those attitudes explain HRM decisions in hypothetical scenarios. Design/methodology/approach Brazilian managers ( n =201) reported their attitudes toward older workers and their decisions in scenarios involving an older vs a younger applicant/worker. Findings In spite of expressing positive attitudes toward older workers, a significant number of managers chose a younger one even when the ...
Tópico(s): Gender Diversity and Inequality
2018 - Emerald Publishing Limited | International Journal of Manpower
A vitória de Rui Moreira nas eleições autárquicas de 2013 no Porto surpreendeu a sociedade portuguesa. A interpretação deste resultado pode ...
Tópico(s): Media Studies and Communication
2016 - Escola Superior de Comunicação Social | Comunicação pública
Produção Nacional
Revisado por pares
Marco Aurélio Salomão Fortes, Maria Vitória Martins Scervino, Gabriel Nasri Marzuca-Nassr, Kaio F. Vitzel, Carlos Hermano da Justa Pinheiro, Rui Curi,
Diabetes mellitus induces a reduction in skeletal muscle mass and strength. Strength training is prescribed as part of treatment since it improves glycemic control and promotes increase of skeletal muscle mass. The mechanisms involved in overload-induced muscle hypertrophy elicited at the establishment of the type I diabetic state was investigated in Wistar rats. The purpose was to examine whether the overload-induced hypertrophy can counteract the hypotrophy associated to the diabetic state. The ...
Tópico(s): Muscle metabolism and nutrition
2017 - Frontiers Media | Frontiers in Physiology
Rui Rodrigues, Vitória Albuquerque, João C. Ferreira, Miguel Sales Dias, Ana Martins,
The increase of greenhouse gas emissions into the atmosphere, and their adverse effects on the environment, have prompted the search for alternative energy sources to fossil fuels. One of the solutions gaining ground is the electrification of various human activities, such as the transport sector. This trend has fueled a growing need for electrical energy storage in lithium batteries. Precisely knowing the degree of degradation that this type of battery accumulates over its useful life is necessary ...
Tópico(s): Electric and Hybrid Vehicle Technologies
2021 - Multidisciplinary Digital Publishing Institute | World Electric Vehicle Journal
Arménio Rego, Andreia Vitória, Tânia Rodrigues Ribeiro, Leonor Ribeiro, Rui Lourenço-Gil, Susana Leal, Miguel Piña e Cunha,
We explored the attitudes toward older workers of African versus Portuguese managers, and how these managers make HRM decisions in scenarios involving younger versus older workers. To make cultural, social, and institutional explanations more robust, we also included two samples of students attending Portuguese universities: one sample comprising African students, the other comprising Portuguese ones. The main findings were: (a) a three-factor model (conscientiousness and performance; social capital ...
Tópico(s): Global Health Care Issues
2020 - Routledge | The International Journal of Human Resource Management
Arménio Rego, Andreia Vitória, Miguel Piña e Cunha, Bradley P. Owens, Ana Clara Ventura, Susana Leal, Camilo Valverde, Rui Lourenço-Gil,
In spite of a growing interest for improvisation in organizations, the microfoundations of improvisation have not been theorized yet. Exploring these microfoundations, we study how employees' psychological capital (PsyCap) acts as a critical cluster of resources to face improvisational challenges and how leaders who convey grit (operationalized as perseverance of effort: Grit-PE), counterbalanced with humility, create conditions to develop those resources. By building upon the conservation of resources ...
Tópico(s): Resilience and Mental Health
2022 - Taylor & Francis | Human Performance
Rui Seixas, Vitoria De Vasconcelos Monteiro, Carla Carneiro, C.L. Vilela, Manuela Oliveira,
<p class="Pa5"><span lang="EN-US">The widespread use of antimicrobials has lead to the emergence of resistant bacteria to one or more antibiotic, including new drugs like linezolid. This antimicrobial is the first of the oxazolidinone group and soon after its approval in 2000, linezolid-resistant MRSA and linezolid vancomycin-resistant enterococci have emerged. Several outbreaks of linezolid-resistant MRSA have been reported worldwide but, to our knowledge, this is the first report of ...
Tópico(s): Biochemical and Structural Characterization
2011 - | Revista Veterinaria
Rui M. M. Brito, Diogo Costa, Carina Dias, Patrícia Cruz, Paula Vitória Macêdo de Barros,
Over the years, chondroitin sulfate (CS) has been used as a slow-acting drug for the treatment of osteoarthritis, for the reduction of pain and improvement of function, and for its disease-modifying properties by limiting cartilage volume loss and joint space narrowing progression. However, there have been inconsistencies in published trials regarding clinical efficacy, with reports of a lack of significant effects compared to placebo. The therapeutic effects of chondroitin sulfate may depend on ...
Tópico(s): Veterinary Equine Medical Research
2023 - Cureus, Inc. | Cureus
Ana Marques, Raquel Marçal, Vitòria Pereira, Patrícia Pereira, C.L. Mieiro, Sofia Guilherme, Carlos Marques, Maria Ana Santos, Rui Pereira, Helena Abreu, Isabel Gaivão, Mário Pacheco,
Tópico(s): Seaweed-derived Bioactive Compounds
2019 - Springer Science+Business Media | Journal of Applied Phycology
João Guilherme Silvestre, Sílvia F. S. Pires, Vitòria Pereira, Miguel Bruno Félix Colaço, Ana P.L. Costa, Amadeu M.V.M. Soares, Domitília Matias, Filipa Bettencourt, Sergio Fernández‐Boo, Rui J. M. Rocha, Andreia C. M. Rodrigues,
Microbiological contamination of bivalve molluscs is one of the major concerns inherent to food safety, thus depuration is frequently needed to assure food safety levels associated with their consumption. Salinity plays an important role in the metabolic activity of bivalves and as such can influence their depuration capacity. This study aimed to evaluate the effect of salinity (25, 30, 35 and 40) on the efficiency of the depuration process, along with the quality and shelf-life of Crassostrea gigas. ...
Tópico(s): Calcium Carbonate Crystallization and Inhibition
2021 - Multidisciplinary Digital Publishing Institute | Water
Gustavo Costa, Rita Garcia, João P. S. Ferreira, Telmo N. Santos, Fábio Branco, Margarida Caramona, Rui A. Carvalho, Augusto M. Dinis, Maria Teresa Batista, Margarida Castel‐Branco, Isabel Vitória Figueiredo,
Cymbopogon citratus is one of the most common herbs used in folk medicine due to its anti-inflammatory and antioxidant properties.Taking into account these properties showed on in vitro assays, the aim of this study was to evaluate the anti-inflammatory and analgesic activities of C. citratus leaves infusion (CcE) and its flavonoid-rich (CcF) and tannin-rich (CcT) fractions.The evaluation of the anti-inflammatory activity was performed in the carrageenan-induced rat paw oedema model.Both central and ...
Tópico(s): Natural Antidiabetic Agents Studies
2015 - | Research Journal of Medicinal Plant
Ana Marques, João Ferreira, Ana Cerqueda-Pacheco, Vitòria Pereira, Helena Abreu, Rui Pereira, Maria João Pires, Fernanda Seixas, Paula A. Oliveira, Isabel Gaivão, Mário Pacheco,
The consumption of marine macroalgae has been linked with health benefits, albeit some actions, including genoprotection, remain underexplored. Hence, we evaluated the genoprotective potential of a mixture of Ulva rigida, Fucus vesiculosus and Gracilaria gracilis, through direct consumption or via indirect intake using fish (Sparus aurata) as a vector of algal phytocompounds. Mice (Mus musculus) were subjected to a 1-month dietary supplementation with 5% of macroalgae mix or 10% of fillet of fish ...
Tópico(s): Marine and coastal plant biology
2022 - Elsevier BV | Food Bioscience
Produção Nacional
Revisado por pares
Gabriela Mandú Gimenes, Giovanna O. Santana, Maria Vitória Martins Scervino, Rui Curi, Joice Naiara Bertaglia Pereira,
The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic ...
Tópico(s): Gut microbiota and health
2022 - Associação Brasileira de Divulgação Científica | Brazilian Journal of Medical and Biological Research
Rui B. Elias, Mariana Reis de Brito, César M M Pimentel, Elisabete Nogueira, Paulo A. V. Borges,
The data presented here come from field observations, carried out between 2014 and 2017, as part of a LIFE research project aiming to preserve and restore three coastal wetlands of Praia da Vitória (Terceira Island, Azores, Portugal) (LIFE-CWR). A total of 23 vascular plant species surveys were carried out in three sites: one for each semester in Paul da Praia da Vitória (PPV) and Paul da Pedreira do Cabo da Praia (PPCP); one for each semester (except in 2014) in Paul do Belo Jardim (PBJ). The main objectives ...
Tópico(s): Marine and coastal plant biology
2019 - Pensoft Publishers | Biodiversity Data Journal
Produção Nacional
Revisado por pares
Vitória Meneghetti Minatel, Carlos Roberto Prudêncio, Benedito Barraviera, Rui Seabra Ferreira,
Since their discovery in the 1990s, heavy chain antibodies have garnered significant interest in the scientific community. These antibodies, found in camelids such as llamas and alpacas, exhibit distinct characteristics from conventional antibodies due to the absence of a light chain in their structure. Furthermore, they possess a single antigen-binding domain known as VHH or Nanobody (Nb). With a small size of approximately 15 kDa, these Nbs demonstrate improved characteristics compared to conventional ...
Tópico(s): Protein purification and stability
2024 - Frontiers Media | Frontiers in Immunology
Cristiana Palmela Pereira, Rui Santos, Valon Nushi, Maria Vitória Lameiro, Patrícia Antunes, Raquel Carvalho, Tatiana Major, Sakher AlQahtani,
Tópico(s): Autopsy Techniques and Outcomes
2023 - Springer Science+Business Media | International Journal of Legal Medicine
Jana Kriebel, Inês M. Gonçalves, Vitória Baptista, María Isabel Veiga, Graça Minas, Rui Lima, Susana O. Catarino,
The effect of nanoparticles on the mechanical behavior of red blood cells (RBCs) under an extensional flow has not been extensively studied. In this work, by using a microfluidic hyperbolic contraction, it is assessed the deformability of healthy RBCs in contact with ∼20 nm nanoparticles of magnetic iron and non-magnetic cerium. The results showed that, under a controlled extensional flow, the healthy RBCs deformability index depended on the cells' velocity along the microfluidic contraction. Additionally, ...
Tópico(s): Advancements in Transdermal Drug Delivery
2023 - Elsevier BV | Experimental Thermal and Fluid Science
Andreia Vitória, Patrícia Faria, Rui Costa,
The expansion of the tourism sector has led to the expansion of unconventional travel trends and the emergence of new forms of business. One of these new forms of business is the sharing economy and the peer-to-peer platforms are the fact that tourists organise their travels without the need for intermediation services. This research presents results from an in depth study focused on a new trend of asset sharing, which has grown exponentially in recent years and addresses the topic of how trust ...
Tópico(s): Digital Marketing and Social Media
2020 - Inderscience Publishers | International Journal of Business and Globalisation
Produção Nacional
Revisado por pares
Diego Ribeiro de Souza, Diogo Antônio Alves de Vasconcelos, Gilson Masahiro Murata, Marco Aurélio Salomão Fortes, Gabriel Nasri Marzuca-Nassr, Adriana Cristina Levada‐Pires, Kaio Fernando Vitzel, Phablo Abreu, Maria Vitória Martins Scervino, Sandro Massao Hirabara, Rui Curi, Tânia Cristina Pithon‐Curi,
• We compared glutamine supplementation and overload inducing EDL muscle hypertrophy. • Glutamine and overload raised muscle fiber cross-sectional area to a similar extent. • Glutamine potentiated the overload-induced increase in the resistance to fatigue. Abstract Glutamine levels directly associate with total protein content in cultured skeletal muscle cells, whereas glutamine supplementation enhances skeletal muscle mass in catabolic experimental conditions. We compared the effect of glutamine administration ...
Tópico(s): Exercise and Physiological Responses
2020 - Elsevier BV | PharmaNutrition