Xenofon Papanikolaou, Sadie Johnson, Tarun K. Garg, Erming Tian, Ruslana G. Tytarenko, Qing Zhang, Joshua Epstein, Bart Barlogie, Joshua Epstein, Christoph Heuck,
... Johnson 1 , Tarun Garg 1 , Erming Tian 1 , Ruslana Tytarenko 1 , Qing Zhang 1 , Caleb Stein 1 , ...
Tópico(s): Cell death mechanisms and regulation
2014 - Impact Journals LLC | Oncotarget
The style [of Ruslana's song “Wild Dances“] can be called “drive-ethno-dance,” a combination of ethnic sounds of the mountain people ... Hutsuls with modern rock, pop and dance elements. (Ruslana n.d.a) Ruslana's winning performance of “Dyki Tantsi” (Wild Dances) ... minority). However, trembity are not only used by Ruslana, but also incorporated into songs by other Ukrainian ... local instruments and melodies in the music which Ruslana in the opening quote labels “drive-ethno-dance” ...
Tópico(s): Soviet and Russian History
2008 - Cambridge University Press | Yearbook for Traditional Music
Elena Campione, Sara Mazzilli, Monia Di Prete, Annunziata Dattola, Terenzio Cosio, Daniele Lettieri‐Barbato, Gaetana Costanza, Caterina Lanna, Valeria Manfreda, Ruslana Gaeta Schumak, Francesca Prignano, Filadelfo Coniglione, Fabrizio Ciprani, Katia Aquilano, Luca Bianchi,
Psoriasis vulgaris is a chronic inflammatory skin disease characterized by well-demarcated scaly plaques. Oxidative stress plays a crucial role in the psoriasis pathogenesis and is associated with the disease severity. Dimethyl fumarate modulates the activity of the pro-inflammatory transcription factors. This is responsible for the downregulation of inflammatory cytokines and an overall shift from a pro-inflammatory to an anti-inflammatory/regulatory response. Both steps are necessary for the amelioration ...
Tópico(s): Mast cells and histamine
2022 - Frontiers Media | Frontiers in Medicine
Marco Galluzzo, Mark S. Talamonti, Arnaldo Cioni, Virginia Maffei, Ruslana Gaeta Shumak, Lorenzo Tofani, Luca Bianchi, Elena Campione,
Tildrakizumab, an IL-23 inhibitor, is effective and safe for the improvement of moderate-to-severe chronic plaque psoriasis. However, little evidence is available on the use of this biologic in psoriasis in difficult-to-treat locations. In this retrospective analysis, we treated patients with 100 mg tildrakizumab at Day 0, after 4 weeks and every 12 weeks thereafter. Disease severity and treatment response was assessed by the Psoriasis Area and Severity Index (PASI), the static Physician's Global ...
Tópico(s): Autoimmune Bullous Skin Diseases
2022 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Giacomo Caldarola, Marco Galluzzo, Nicoletta Bernardini, Laura Calabrese, Marta Grimaldi, Gaia Moretta, Gianluca Pagnanelli, Ruslana Gaeta Shumak, Mark S. Talamonti, Lorenzo Tofani, Sabatino Pallotta, Ketty Peris, Concetta Potenza, Clara De Simone, Elena Campione,
New biologic agents targeting interleukin (IL)23/T-helper17 axis, such as tildrakizumab, have been developed for the treatment of plaque psoriasis. To analyze the efficacy and safety of tildrakizumab in a real life setting of patients affected by moderate-to-severe psoriasis over a 28-week treatment period. A multicentric retrospective study was conducted in patients who initiated tildrakizumab between February 2020 and March 2021. Psoriasis Area and Severity Index-PASI was measured at baseline and ...
Tópico(s): Asthma and respiratory diseases
2022 - Wiley | Dermatologic Therapy
Seyed Mohammad Hadi Safaei, Mohammad Dadpasand, Mohammadreza Mohammadabadi, H. Atashi, Ruslana Stavetska, N. Klopenko, Oleksandr Kalashnyk,
Myogenin is a protein in the myogenic regulatory factor family that plays an important role in determining carcass and meat traits and is vital for the growth and development of livestock muscles. The objective of this study was to determine the impact of Origanum majorana leaf (MOL) on the myogenin gene expression of lambs. Twenty-four male Kermani lambs were used in a completely randomized design using two experimental groups (0% Origanum majorana L. = MOL0 and 4% Origanum majorana L. = MOL4). Final ...
Tópico(s): Rabbits: Nutrition, Reproduction, Health
2022 - Multidisciplinary Digital Publishing Institute | Animals
Eileen M. Boyle, Shayu Deshpande, Ruslana G. Tytarenko, Cody Ashby, Yan Wang, Michael Bauer, Sarah K. Johnson, Christopher P. Wardell, Sharmilan Thanendrarajan, Maurizio Zangari, Thierry Façon, Charles Dumontet, Bart Barlogie, Arnaldo Arbini, Even H Rustad, Francesco Maura, Ola Landgren, Fenghuang Zhan, Frits van Rhee, Carolina Schinke, Faith E. Davies, Gareth J. Morgan, Brian A. Walker,
Smoldering myeloma (SMM) is associated with a high-risk of progression to myeloma (MM). We report the results of a study of 82 patients with both targeted sequencing that included a capture of the immunoglobulin and MYC regions. By comparing these results to newly diagnosed myeloma (MM) we show fewer NRAS and FAM46C mutations together with fewer adverse translocations, del(1p), del(14q), del(16q), and del(17p) in SMM consistent with their role as drivers of the transition to MM. KRAS mutations are ...
Tópico(s): Cancer Mechanisms and Therapy
2021 - Nature Portfolio | Nature Communications
Leila Mohamadipoor Saadatabadi, Mohammadreza Mohammadabadi, Zeinab Amiri Ghanatsaman, Olena Babenko, Ruslana Stavetska, Oleksandr Kalashnyk, Д. М. Кучер, Oleksandr Kochuk-Yashchenko, Hojjat Asadollahpour Nanaei,
Abstract Background Sheep were among the first animals to be domesticated. They are raised all over the world and produce a major scale of animal-based protein for human consumption and play an important role in agricultural economy. Iran is one of the important locations for sheep genetic resources in the world. Here, we compared the Illumina Ovine SNP50 BeadChip data of three Iranian local breeds (Moghani, Afshari and Gezel), as a population that does not undergone artificial breeding programs ...
Tópico(s): Genetic Mapping and Diversity in Plants and Animals
2021 - BioMed Central | BMC Veterinary Research
Ruslana S. Khodzhaieva, Eugene S. Gladkov, Alexander Kyrychenko, Alexander D. Roshal,
In recent years, the chemistry of flavonoid glycosylation has undergone significant developments. This mini-review is devoted to summarizing existing strategies and methods for glycosylation of natural and synthetic flavonoids. Herein we overviewed the reaction conditions of flavonoid glycosylation depending on the position of hydroxyl groups in a parent molecule, the degree of it conjugation with the π-system, the presence of steric factors, the formation of intramolecular hydrogen bonds, etc. ...
Tópico(s): Synthesis of Organic Compounds
2021 - Frontiers Media | Frontiers in Chemistry
Mansour Al Qubeissi, С.С. Сажин, Nawar Al-Esawi, Ruslana Kolodnytska, B. Khanal, M. Ghaleeh, Ahmed Elwardany,
In this review, recent models for the heating/evaporation of multicomponent and blended fuel droplets and their implementation into numerical codes, used for the analysis of the processes in internal combustion engines, are reviewed. In these models, the diffusion of species, recirculation, and temperature gradient inside droplets are considered. The focus of the review is on the group of models based on the implementation of the analytical solutions to the heat transfer and species diffusion equations ...
Tópico(s): Combustion and flame dynamics
2021 - American Chemical Society | Energy & Fuels
Elia Zomot, Hadas Achildiev Cohen, Inbal Dagan, Ruslana Militsin, Raz Palty,
Store-operated calcium entry (SOCE) through the Ca2+ release–activated Ca2+ (CRAC) channel is a central mechanism by which cells generate Ca2+ signals and mediate Ca2+-dependent gene expression. The molecular basis for CRAC channel regulation by the SOCE-associated regulatory factor (SARAF) remained insufficiently understood. Here we found that following ER Ca2+ depletion, SARAF facilitates a conformational change in the ER Ca2+ sensor STIM1 that relieves an activation constraint enforced by the STIM1 ...
Tópico(s): Connexins and lens biology
2021 - Rockefeller University Press | The Journal of Cell Biology
Mohammadreza Mohammadabadi, Seyed Hojat Masoudzadeh, A. Khezri, Oleksandr Kalashnyk, Ruslana Stavetska, N. Klopenko, Valentyna Oleshko, S. V. Tkachenko,
Delta-Like Non-Canonical Notch Ligand 1 (DLK1) is one of the key genes involved in the development of muscle, liver, pancreas, and lung cells; adipocytes production; and the improvement of digestion, growth performance, and meat quality. It has been documented that fennel is effective on increasing the DLK1 gene (DLK1) expression in the testis, liver, and muscle tissues, which may consequently have important implications for sheep production. Hence, the aim of the current investigation was to evaluate ...
Tópico(s): Bone Metabolism and Diseases
2021 - Elsevier BV | Heliyon
Едуард Балашов, Ihor Pasichnyk, Ruslana Kalamazh,
The presented manuscript has analysed the theoretical aspects of the concepts of metacognitive awareness and academic self-regulation of HEI students. A theoretical essence of the mentioned above phenomena has been theoretically studied. The role and importance of metacognitive awareness and its components for the learning efficiency and academic self-regulation of HEI students have been described. It has been determined that such a metacognitive characteristic of personality as metacognitive awareness ...
Tópico(s): Educational Innovations and Challenges
2021 - Association for the Development of Science, Engineering and Education | International Journal of Cognitive Research in Science Engineering and Education
Eileen M. Boyle, Cody Ashby, Ruslana G. Tytarenko, Shayu Deshpande, Hongwei Wang, Yan Wang, Adam Rosenthal, Jeffrey R. Sawyer, Erming Tian, Erin Flynt, Antje Hoering, Sadie Johnson, Michael Rutherford, Christopher P. Wardell, Michael Bauer, Charles Dumontet, Thierry Façon, Sharmilan Thanendrarajan, Carolina Schinke, Maurizio Zangari, Frits van Rhee, Bart Barlogie, David A. Cairns, Graham Jackson, Anjan Thakurta, Faith E. Davies, Gareth J. Morgan, Brian A. Walker,
Copy-number changes and translocations have been studied extensively in many datasets with long-term follow-up. The impact of mutations remains debated given the short time to follow-up of most datasets.We performed targeted panel sequencing covering 125 myeloma-specific genes and the loci involved in translocations in 223 newly diagnosed myeloma samples recruited into one of the total therapy trials.As expected, the most commonly mutated genes were NRAS, KRAS, and BRAF, making up 44% of patients. ...
Tópico(s): Cancer Mechanisms and Therapy
2020 - American Association for Cancer Research | Clinical Cancer Research
Aly Badran, David B. Marshall, Zacharie Legault, Ruslana Makovetsky, Benjamin Provencher, Nicolas Piché, Mike Marsh,
Tópico(s): Non-Destructive Testing Techniques
2020 - Springer Science+Business Media | Journal of Materials Science
Seyed Hojat Masoudzadeh, Mohammadreza Mohammadabadi, A. Khezri, Oleksandr Kochuk-Yashchenko, Д. М. Кучер, Olena Babenko, Марина Віталіївна Буштрук, S. V. Tkachenko, Ruslana Stavetska, N. Klopenko, Valentyna Oleshko, Mark Tkachenko, I.V. Titarenko,
Delta-like 1 homolog or pre-adipocyte factor 1 (Dlk1) is one of the most significant genes and widely expresses all over mammal’s development. Some of the functions identified for Dlk1gene are development of muscle, healing of wound, adipocytes proliferation, liver, lung and pancreas development. It also prevents Notch gene conducting toward to govern several operations such like cellular proliferation and differentiation. The aim of this study was to assay the expression of Dlk1 gene in liver, humeral ...
Tópico(s): Nitrogen and Sulfur Effects on Brassica
2020 - Islamic Azad University of Rasht | Iranian journal of applied animal science
Tobias Meitzel, Ruslana Radchuk, Erin L. McAdam, Ina Thormählen, Regina Feil, E. Muñz, Alexander Hilo, Peter Geigenberger, John J. Ross, John E. Lunn, Ljudmilla Borisjuk,
Plants undergo several developmental transitions during their life cycle. One of these, the differentiation of the young embryo from a meristem-like structure into a highly specialized storage organ, is believed to be controlled by local connections between sugars and hormonal response systems. However, we know little about the regulatory networks underpinning the sugar-hormone interactions in developing seeds. By modulating the trehalose 6-phosphate (T6P) content in growing embryos of garden pea ( ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2020 - Wiley | New Phytologist
Samrat Roy Choudhury, Cody Ashby, Ruslana G. Tytarenko, Michael Bauer, Yan Wang, Shayu Deshpande, Judith Den, Carolina Schinke, Maurizio Zangari, Sharmilan Thanendrarajan, Faith E. Davies, Frits van Rhee, Gareth J. Morgan, Brian A. Walker,
Abstract Background Multiple Myeloma (MM) is a hematological malignancy with genomic heterogeneity and poor survival outcome. Apart from the central role of genetic lesions, epigenetic anomalies have been identified as drivers in the development of the disease. Methods Alterations in the DNA methylome were mapped in 52 newly diagnosed MM (NDMM) patients of six molecular subgroups and matched with loci-specific chromatin marks to define their impact on gene expression. Differential DNA methylation ...
Tópico(s): Histone Deacetylase Inhibitors Research
2020 - BioMed Central | Journal of Hematology & Oncology
Scott Drutman, Davood Mansouri, Seyed Alireza Mahdaviani, Anna‐Lena Neehus, David Hum, Ruslana Bryk, Nicholas Hernandez, Serkan Belkaya, Franck Rapaport, Benedetta Bigio, Robert O. Fisch, Mahbuba Rahman, Taushif Khan, Fatima Al Ali, Majid Marjani, Nahal Mansouri, Lazaro Lorenzo, Jean‐François Emile, Nico Marr, Emmanuelle Jouanguy, Jacinta Bustamante, Laurent Abel, Stéphanie Boisson‐Dupuis, Vivien Béziat, Carl Nathan, Jean‐Laurent Casanova,
Cytomegalovirus (CMV) can cause severe disease in children and adults with a variety of inherited or acquired T-cell immunodeficiencies, who are prone to multiple infections. It can also rarely cause disease in otherwise healthy persons. The pathogenesis of idiopathic CMV disease is unknown. Inbred mice that lack the gene encoding nitric oxide synthase 2 (Nos2) are susceptible to the related murine CMV infection.We studied a previously healthy 51-year-old man from Iran who after acute CMV infection ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2020 - Massachusetts Medical Society | New England Journal of Medicine
Seyed Hojat Masoudzadeh, Mohammadreza Mohammadabadi, A. Khezri, Ruslana Stavetska, Valentyna Oleshko, Olena Babenko, Zoya Yemets, Oleksandr Kalashnyk,
DLK1 (protein delta homolog 1) plays an important role in production of adipocytes, muscle development, wound healing, pancreas, liver and lung cells development and also in the development of meat quality, digestion and growth performance. Therefore, the goal of this research was to investigate the effects of different levels of fennel seed power in the diet on growth performance and on DLK1 gene expression in brain, adipose, femur (leg) muscle and rumen muscle tissues of Kermani lambs. Dietary treatments ...
Tópico(s): Genetic and phenotypic traits in livestock
2020 - Elsevier BV | Small Ruminant Research
Meghanath Prabhu, Álvaro Israel, Ruslana Rachel Palatnik, David Zilberman, Alexander Golberg,
Tópico(s): Plant Growth Enhancement Techniques
2020 - Springer Science+Business Media | Journal of Applied Phycology
Shayu Deshpande, Ruslana G. Tytarenko, Yan Wang, Eileen M. Boyle, Cody Ashby, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Fenghuang Zhan, Faith E. Davies, Gareth J. Morgan, Frits van Rhee, Brian A. Walker,
Abstract Circulating cell‐free DNA (cfDNA) has the potential to capture spatial genetic heterogeneity in myeloma (MM) patients. We assessed whether cfDNA levels vary according to risk status defined by the 70 gene expression profile (GEP70). cfDNA levels in 77 patients were significantly higher in the GEP70 high‐risk (HR) group compared to the low‐risk (LR) group and correlated weakly with clinical markers including lactate dehydrogenase, β 2 ‐microglobulin, and ISS. Patients with high cfDNA levels were ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2020 - Wiley | European Journal Of Haematology
Maxim Shevtsov, Stefan Stangl, B. P. Nikolaev, L. Yakovleva, Yaroslav Marchenko, Ruslana Tagaeva, Wolfgang Sievert, Emil Pitkin, Anton S. Mazur, Peter M. Tolstoy, Oleg Galibin, V. A. Ryzhov, Katja Steiger, О. П. Смирнов, W. А. Khachatryan, Kerry Chester, Gabriele Multhoff,
Abstract Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as potential clinical tools for cancer theranostics. Membrane‐bound 70 kDa heat shock protein (mHsp70) is ubiquitously expressed on the cell membrane of various tumor types but not normal cells and therefore provides a tumor‐specific target. The serine protease granzyme B (GrB) that is produced as an effector molecule by activated T and NK cells has been shown to specifically target mHsp70 on tumor cells. Following ...
Tópico(s): Radiation Therapy and Dosimetry
2019 - Wiley | Small
Nawar Al-Esawi, Mansour Al Qubeissi, Ruslana Kolodnytska,
The interest in biofuels was stimulated by the fossil fuel depletion and global warming. This work focuses on the impact of biodiesel fuel on ethanol/diesel (ED) fuel blends. The soybean methyl ester was used as a representative composition of typical biodiesel fuels. The heating and evaporation of ethanol–biodiesel–diesel (EBD) blends were investigated using the Discrete–Component (DC) model. The Cetane Number (CN) of the EBD blends was predicted based on the individual hydrocarbon contributions in ...
Tópico(s): Thermochemical Biomass Conversion Processes
2019 - Multidisciplinary Digital Publishing Institute | Energies
Christopher Duma, Oleg V. Kopyov, Oleg V. Kopyov, Mark Berman, Elliot Lander, Michael V. Elam, Michael Arata, David Weiland, Ruslana Cannell, Chad A. Caraway, Sean Berman, Kristin Scord, Lian Stemler, Karlyssa Chung, Samuel Khoudari, Rory McRory, Chace Duma, Sawyer Farmer, Anthony Bravo, Christian Yassa, Ami Sanathara, Elisa Singh, Benjamin Rapaport,
We have chosen to test the safety of human intracerebroventricular (ICV) brain injections of autologous non-genetically-modified adipose-derived stromal vascular fraction (ADSVF). In this IRB-approved trial, 24 patients received ICV ADSVF via an implanted reservoir between 5/22/14 and 5/22/17. Seven others were injected via their ventriculo-peritoneal shunts. Ten patients had Alzheimer's disease (AD), 6 had amyotrophic lateral sclerosis (ALS), 6 had progressive multiple sclerosis (MS-P), 6 had Parkinson' ...
Tópico(s): Amyotrophic Lateral Sclerosis Research
2019 - Springer Nature | Molecular Biology Reports
Ruslana Harhaun, Oleksandra Kunik, Diana Saribekova, Giuseppe Lazzara,
Describes biologically active properties waters plant extracts of domestic herbaceous species as a part cosmetic emulsion in this article. In particular, the antioxidant features related to vitamins, flavonoids, coloring, extractive and tannins were reported. The following research methods as qualitative analysis on groups of biologically active substances, thin-layer chromatography, titrimetry and photometry were used in the work. The ability of extracts to influence the physico-chemical, organoleptic ...
Tópico(s): Essential Oils and Antimicrobial Activity
2019 - Elsevier BV | Microchemical Journal
А. В. Соболев, Олександр Іванович Соболєв, B. V. Gutyj, Б. В. Гутий, L. M. Darmohray, Любомир Мирославович Дармограй, Svitlana Soboleva, Світлана Іванівна Соболєва, В. В. Іваніна, Вадим Віталійович Іваніна, Oksana Kuzmenko, Oksana Kuzmenko, Peter Karkach, Петро Михайлович Каркач, V. Fesenko, Василь Федорович Фесенко, Vita Bilkevych, Віта Володимирівна Бількевич, Yurii Mashkin, Юрій Олексійович Машкін, A. M. Trofymchuk, Алла Михайлівна Трофимчук, Ruslana Stavetska, Руслана Володимирівна Ставецька, Serciy Tkachenko, Сергій Васильович Ткаченко, О. А. Бабенко, Olena Babenko, Natalia Klopenko, Наталія Ігорівна Клопенко, Sergii Chernyuk, Сергій Васильович Чернюк,
Літій посідає особливе місце серед мікроелементів, які за життєвою необхідністю для організму рослин, тварин і людини відносяться до умовно есенціальних. Проте, на сьогодні він розглядається як “серйозний кандидат на есенціальність”. Літій є природним елементом з унікальними фізико-хімічними властивостями, які і визначать його біологічну роль в організмі. У низьких концентраціях літій оказує позитивний вплив на фізіологічні процеси в живих організмах, тоді як високі дози, викликають інтоксикацію ...
Tópico(s): Scientific Research and Studies
2019 - Alex Matsyura Publishing | Ukrainian Journal of Ecology
Keren Yizhak, François Aguet, Jaegil Kim, Julian M. Hess, Kirsten Kübler, Jonna Grimsby, Ruslana Frazer, Hailei Zhang, Nicholas J. Haradhvala, Daniel Rosebrock, Dimitri Livitz, Xiao Li, Eila Arich-Landkof, Noam Shoresh, Chip Stewart, Ayellet V. Segrè, Philip A. Branton, Paz Polak, Kristin Ardlie, Gad Getz,
How somatic mutations accumulate in normal cells is poorly understood. A comprehensive analysis of RNA sequencing data from ~6700 samples across 29 normal tissues revealed multiple somatic variants, demonstrating that macroscopic clones can be found in many normal tissues. We found that sun-exposed skin, esophagus, and lung have a higher mutation burden than other tested tissues, which suggests that environmental factors can promote somatic mosaicism. Mutation burden was associated with both age ...
Tópico(s): Single-cell and spatial transcriptomics
2019 - American Association for the Advancement of Science | Science
Michael Timaner, Ruslana Kotsofruk, Ziv Raviv, Ksenia Magidey, Dvir Shechter, Tal Kan, A. Nevelsky, Shahar Daniel, Elisabeth G.E. de Vries, Tongwu Zhang, Orit Kaidar‐Person, Robert S. Kerbel, Yuval Shaked,
Abstract Radiotherapy induces immune-related responses in cancer patients by various mechanisms. Here, we investigate the immunomodulatory role of tumor-derived microparticles (TMPs)—extracellular vesicles shed from tumor cells—following radiotherapy. We demonstrate that breast carcinoma cells exposed to radiation shed TMPs containing elevated levels of immune-modulating proteins, one of which is programmed death-ligand 1 (PD-L1). These TMPs inhibit cytotoxic T lymphocyte (CTL) activity both in vitro ...
Tópico(s): Immunotherapy and Immune Responses
2019 - Springer Nature | Oncogene
Oxana Verkholyak, Heysem Kaya, Alexey Karpov,
... emotional speech corpora in three different languages, namely RUSLANA (Russian speech), BUEMODB (Turkish speech) and EMODB (German ...
Tópico(s): Speech and Audio Processing
2019 - St. Petersburg Institute for Informatics and Automation | SPIIRAS Proceedings