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Jonathan Northcroft, John Dugdale, Nicholas Pyke, Matthew Wall, Helena Frith Powell, Aa Gill, Scott Athorne, Nigel Botherway, Sandy Gauld, Barbara Hall, N J, Fred Redwood, Eduardo Goncalves, Michael Burleigh, Helen Davies, Nicholas Rufford, Ricky Gervais, Rob Hughes, Jason Dawe, John Peter, V S, Boris Schapiro, Mark Hodgkinson, Emma Moore, Sue Chester, Jonathan Miller, Alan D Wright, Robin Eggar, Sharon Walker, Kate Spicer, David Gray, J D, Amanda Hall, Gareth Walsh, Frank Whitford, Nick Leslau, Chris Kline, Dawna Walter, Nicolette Jones, Terence Blacker, John Reyntiens, Ferdinand Mount, Matt Wolf, Kathryn Cooper, Claus von Bulow, David Smith, Humphrey Carpenter, Maureen Clarke, Tim Richards, Peter Sharkey, Rory Godson, David Cracknell Political Editor, Borris Threar, Steven Poole, James Dean, Neil Wormald, E P, Sir Michael Salt, Guy Bellamy, Andrew Sullivan, Clive Davis, Monsiour Mangetout, Stephen Grey, Leslie Fraser-Mitchell, Jeremy, L Stebbings, Martin James, D C, Mary Laskin, Rob Lee, Tom Walker, Robert Winnett, Gavin, Irwin Stelzer, Peter Wilson, David Dougill, Stanley Henig, Rachel Dobson, Nicholas Hellen Social Affairs Editor, Eleanor Davies, Jenni Muir, Geraldine Hackett, H C, David Hewson, Michael Gillard, Cally Law, David Bond, William Dalrymple, Hugh Canning, Alasdair Reid, Margarette Driscoll, Geraldine Hackett Education Correspondent, Nils Pratley, Jeremy Clarkson, Andrew Stone, Joe Swift, Peter Conradi, Steve Coogan, Louise Taylor, Edward Porter, David Cairns, Stewart Lee, S L, Helen Kenny, Eben Black, Sean Newson, John O'Donnell, Anita Chaudhuri, Liz Edwards, Peter Oliver, Pam Barren, Adam Nathan, Shelley von Strunckel, Jeremy Guscott, Richard Johnson, Chris Johnston, Rev Andrew de Berry, Raymond Blanc, Stuart Wavell, Christopher Silvester, Paul Donovan, Tom Conran, Douglas Brown, Peter Hounam, James Douglas, Zoe Thomas, R U I, Hugh McIlvanney, Nicholas Hellen Social Affairs editor, Chris Woodhead, Lisa Jardine, Lucinda Kemeny, Steve Boyd, Jasper Gerard, Steven Norris, Michael Woodhead, Paul Driver, John Humphrys, Nigel Bothelway, Ann McFerran, Richard Brooks, Jacob de Vries, Monroe, Ian Hawkey, Orson, Penny Vincenzi, Julian Corlett, David Leppard, Paul Durman, Hugh Jamieson, Alicia Wyllie, Richard Girling, Mark Edwards, Mick Dennis, Stephen Amidon, David Lawrenson, Matthew Sheahan, Eben Black Chief Political Correspondent, Susan Clark, Gabriella Gamini, Frank Worth, Danny O'Brien, R Kurt, Victoria O'Brien, Alan Combes, David Stonebanks, Sean Newsom, M Thompson, Raymond Keene, Gareth Huw Davies, Douglas Alexander, Alan Clark, David Cracknell, David Lappard, Nick Hoskins, Joan Wright, Marie Colvin, Senay Boztas, Diana Wright, Cosmo Landesman, Kipper Williams, Chris Hughes, Paul Parry, Stephen Jones, Dominic O'Connell, Andrew Holgate, Barry Flatman, Nick Cain, Louise Armitstead, Michael Wright, Peta Bee, Melinda Stevens, Natalie Graham, Jeremy Scott, Kate Rew, M J, Caroline Donald, Rob Ryan, Miranda Seymour, David Walsh, Jack Grimston, Colin McDowell, Stephen Armstrong, John Elliott, Elizabeth Jane Howard, Nick MacKinnon, Colin McDowell's, M L, Michael Sheridan Far East Correspondent, Bethan Cole, Jonathan Leake Environment Editor, David Price, Bob Mulholland, Alan Robertson, Ruth Rendell, Rory Godson Business Editor, Johnny Davies, Maurice Chittenden, Kevin Pratt, N D, Richard Brooks Arts Editor, D R M, Cilla Black, Victoria Segal, Richard Rae, Mark Franchetti, Frank Fitzgibbon, Ray Hutton, Prof Gideon Garter, G S, Georgina Wroe, Saily Kinnes, Rita Konig, Charlene Woodcock, Brendan Simms, Peter Clark, M Simons, John Harlow, Godfrey Smith, Robert Winnett Consumer Affairs Correspondent, Barry Collins, Dipesh Gadher, John Waples, K J Nicholson, Denis Walsh, Matthew Campbell, Brian Glanville, John Busby, Louise Johncox, Sasha Slater, Frankie Cole, Tom Robbins, Sarah, Nick Fielding, Tony Benn, Stephen Pettitt, Justin Sparks, Tom Walker Diplomatic Correspondent, Patrick, Naomi Caine, Liam Clarke, David Wickers, Nigel Powell, Peter Schmeichel, Minette Marrin, Marcelle Katz, Mark Hodson, Andrew Frankel, Graham Norwood, Joe Lovejoy, Rupert Steiner, David Budworth, Helen, Hugh Pearman, Dan Cairns, Paul Stephen Lubicz, Steve Henley, Dr Tania Gergel, Chris Riddell, Huw Beynon, John Wapies, David Smith Economics Editor, Ben Rooney, Jerome Gardner, Anthony Howard, Sarah Baxter, Helen Vandevelde, Peter Roebuck, Colin Bridger, Joanna Simon, Mark Hodgkpison, Matthew Goodman, India Knight, Alan Chevin, Steve Grant, Kingston Smith, Stephen Applebaum, Danny Danziger, Philip Jacobson, Barry Newcombe, Kenneth Anderson, Dominic Rushe, Richard Lewis, Sian Griffiths, Karen Robinson,

... What Happens on a Saturday Night in Slovakia? Nemeth the enemy within They are among the minnows ... it to the sun. David Wickes and Rob Ryan present 50 great escapes, from all-action Australia ...

2002 - Gale Group | Sunday Times HA GDA

Artigo

David J. Sauchyn, Jeannine‐Marie St‐Jacques, Elaine Barrow, Michael W. Nemeth, Ryan J. MacDonald, A. Michael S. Sheer, Daniel P. Sheer,

Abstract The South Saskatchewan River Basin is one of Canada's most threatened watersheds, with water supplies in most subbasins over‐allocated. In 2013, stakeholders representing irrigation districts, the environment, and municipalities collaborated with researchers and consultants to explore opportunities to improve the resiliency of the management of the Oldman and South Saskatchewan River subbasins. Streamflow scenarios for 2025‐2054 were constructed by the novel approach of regressing historical ...

Tópico(s): Flood Risk Assessment and Management

2016 - Wiley | JAWRA Journal of the American Water Resources Association

Jornais Acesso aberto

Jonathan Northcroft, Carlos Alba, John Dugdale, Hala Jaber, Nicolas Balfour, Led Zeppelin, Matthew Wall, Barbara Hall, Joan Bakewell, Dan O'Neill, Nigel Botherway, John Smith, Cerys Atkins, June Garfield, E H Davies, Tracey Cox, Heten Vandevelde, N J, Jim Munro, Peter Whittle, Paula Radcliffe, Helen Davies, Sally Brock, Nicholas Rufford, Rita Konig, Rob Hughes, Peter Colons, David Moseley, Indigo Thomas, John Peter, Mark Hodgkinson, Olga Lockley, Professor Gideon Garter, Emma Moore, Amanda Ursell, Abigail Falkner, Andrew Longmore, Lesley White, Jane Mulkerrins, Christopher Somerville, J D, Susan d'Arcy, Gail Robinson, Gareth Walsh, Frank Whitford, Dawna Walter, Ferdinand Mount, Kathryn Cooper, John Elliot, Lucy Hughes-Hallett, David Smith, Pamela Anderson, Tim Richards, Maynard Gilchrist, Peter Sharkey, Rory Godson, J M Coetzee, John Curtis, Neil Wormald, E P, Andrew Sullivan, Clive Davis, Lynne Truss, C D, Jeremy, Tony Allen-Mills, Simon Wilde, D C, Martin James, Anthony Sattin, Robert Winnett, T E, Irwin Stelzer, Peter Wilson, David Dougill, Rachel Dobson, Peter Cook, High Canning, Phil Baty, Ann Corkett, H C, Cally Law, David Bond, Jonathon Carr-Brown, Alasdair Reid, Margarette Driscoll, Geraldine Hackett Education Correspondent, Nils Pratley, Jeremy Clarkson, David Cairns, Peter Olive, Edward Porter, Stewart Lee, Louise Taylor, Graham Dufill, S L, Victoria Segal, David Taylor, Patricia Nicol, Helen Kenny, Eben Black, John O'Donnell, R Plumb, Liz Edwards, Nelson Mandela, George Hart, Ruperrt Steiner, Adam Nathan, Stelios Haji-Loannou, Shelley von Strunckel, Jeremy Guscott, Anthony philiphs, Micheal Morpurgo, Jill Douglas, Richard Johnson, Peter Parker, Christopher Silvester, Stuart Wavell, Roger Eglin, Tom Conran, Dominique Coughlin, Glenn Gale, Vincent Crump, Hugh McIlvanney, Chris Woodhead, Jane Herald, Stan Labovitch, Lucinda Kemeny, Jasper Gerard, Paul Driver, Michael Woodhead, Garth Pearce, Ann McFerran, Maeve Sheehan, Edith Bowman, Richard Brooks, Ian Hawkey, Christopher Morgan, David Leppard, Denise Ryan, Paul Durman, Mark Ludlow, Adam Jolly, Alicia Wyllie, Mark Edwards, Simon Louvish, Louis de Bernierres, Mick Dennis, Susan Clark, Matthew Sheahan, Wendy Pott, W S Graff-Baker, Lucy Wakefield, Hugo Barnacle, Charlie Hedley, Michael Palin, Derek Wilcox, Victoria O'Brien, Marion Bull, Raymond Keene, Peter Martin, Kale Rew, Chris Robinson, Nils pratley, Gareth Huw Davies, Douglas Alexander, David Cracknell, Anthony ffrench-Constant, Roger Waters, Cosmo Landesman, Marie Colvin, Diana Wright, Peter Lampl, S B, Stephen Jones, Dominic O'Connell, S G, Louise Armitstead, Nick Cain, Henry Sterman, Graham Senior, Natalie Graham, C A Ryder, Bev Osborne, Caroline Donald, M J, Jessica Brinton, David Walsh, Jeremy Paxman, Steve Fitzgerald, John Stern, Jack Grimston, Colin McDowell, Lois Rogers Medical Correspondent, Stephen Armstrong, Sean Thomas, Ron Clarke, Elizabeth Jane Howard, Jackle Cooper, Colin McDowell's, Michael Sheridan Far East Correspondent, Sheherazade Goldsmith, Richard Woods, Roland White, Stephen magill, Robert White, Eddie Hawkins, Maurice Chittenden, Dave Stewart, Donna Tartt, Andrew Mueller, Jason Bell, Richard Brooks Arts Editor, Matthew Brace, Judith O'Reilly, Mark Franchetti, Richard Rae, Frank Fitzgibbon, Ray Hutton, Andy Warhol, Bridan Doogan, Andy Warnol, Ria Higgins, Jonathan Leake, Alexandra Dawe, M E, Leah Hardy, Tony Allen-Mills Independence, Michael Sheridan, Marathon, Lesley Cunliffe, Bikini Line, John Harlow, John Mortumer, Godfrey Smith, Barry Collins, Dipesh Gadher, Andrew Frankal, John Waples, Hunter Davies, Haruki Murakami, Ros Dodd, Matthew Campbell, Brian Glanville, Robert Steiner, Louise Johncox, John Carey, Martin Wroe, Tom Robbins, Mary Braid, John humphrys, Johan Schronen, jane mulkerrins, Jason Mellor, Lewis Stuart, Stephen Pettitt, Jonathan Calvert, John Mitchell, Justin Sparks, Sally Kinnes, Veronica Grookcock, Naomi Caine, Nigel Powell, Alan Thomas, David Wickers, Gill Wright, Caroline Turriff, Brian Doogan, John Aizlewood, Minette Marrin, Jeremy Lazell, Marcelle Katz, Mark Hodson, Graham Norwood, Chris Moore, Joe Lovejoy, Jonathan Futrell, Rupert Steiner, David Budworth, Hugh Pearman, Stephen Hird, Paul Stephen Lubicz, Dan Cairns, Christopher Bray, David Smith Economics Editor, Ben Rooney, Vanya Kewley, Niall Quinn, Anthony Howard, Sarah Baxter, Chris Feetenby, Matthew Goodman, Lord Macdonald, Steve Grant, Simon Howard, Danny Danziger, Jason Dawe, Lisa Verrico, Dominic Rushe, Barry Bolton,

... at his best in an unfamiliar midfield role Nemeth proves to be enemy at the Gates England' ... on top? A break in the clouds Denise Ryan's mood was as foul as the weather— ...

2002 - Gale Group | Sunday Times HA GDA

Revisão Revisado por pares

Edward W. Petrillo, Miguel A. Ondetti,

... A. D. Essenburg, R. B. Parker, V. L. Nemeth, M. J. Ryan, D. H. Dugan, and H. R. Kaplan, J. ...

Tópico(s): Vitamin K Research Studies

1982 - Wiley | Medicinal Research Reviews

Jornais Acesso aberto

Sir William Lithgow Chairman, Gareth Bowen, Dilip Rao, John Huxley, Audrey Parry, A M W Zaman, Lynne Greenwood, Barbara Hall, Ewen Cameron Chairman, Joan Bakewell, Mike Graham, John Jay City Editor, Michelene Wandor, Oliver Anderson, Lewis de Fries, Rob Hughes, John Peter, Alex Higgins, Eric Dymock, Hannah Pearce, Norman MacRae, Clive King, John Jay, Tony Atherton, Nick Rufford, John Diamond, Graham Rose, Diana Wright Personal Finance Editor, Alistair Scott, Sally Payne, Louis Fitzgibbon, J Chaplin, Nick Pitt, Julian Joyce, Timothy Ross, Jason Tomas, John Rowland, Mark Hosenball, Edward Welsh, Carol Sarler, Harry Eyres, Gerald Priestland, Richard Eaton, Jon Craig, Geordie Greig, Neville Hodgkinson, Patrick Stoddart, Mario Modiano, Susan Marling, Alex Sutherland, Iain Johnstone, Frances Williams, Robert Sandall, Jan Knappert, Irwin Stelzer, Jonathan Wordsworth, Peter Godwin, Ivan Fallon, Mark Ottaway, Mick Brown, Deryk Brown, David Dougill, Mark Fisher, Robert Hewison, Dymphna Byrne, Wendy Cope, Heather Higgins, Jane Bird, Charles Qulton Religious Affairs Correspondent, B Higgs Director General, John Witherow, Geraldine Hackett, Jonathan Rowe, Margaret Summers, Hugh Canning, Sulaiman Al-Tuwaijri, Susan Crosland, David Cairns, David Goldsmith, Norman Harris, Philip Williams, Susan Grossman, Ibrahim Hewitt, Geoff Whitten, Libby Purves, Robert Harris, Jeremy Laurance Health Services Correspondent, Melanie Norris, David Moreau, George Perry, John Cassidy, Sue Mott, Sandra Hempel, Jonathan Bastable, Joe Klein, Andrew Grice Political Reporter, Christine Toomey, Liz Goodenough, Brian Moynahan, Bernard Cafferty, Nicholas Anderson, Nicola Shulman, Paul Donovan, Janette Marshall, John Izbicki, Amit Roy, Nigel Seymer, Jeff Randall, Jonathan Todd, Robert Forrest, James Adams, Boris Schapiro, Bernard Holland, Michael Cadman, David Hughes, Caroline Cox, Austin MacCurtain, David Leppard, George Scales Director, Sir Robert Reid, Linda Hunt, Elizabeth Grice, Wendy McFadden, David Lawrenson, John Hopkins, Keith Orrell, Askold Krushelnycky, Norman Longmate, Frank Delaney, Brian Walden, Robin Marlar Our Cricket Correspondent, Jonathan Raban, Gareth David, Brian Reading, Stephen Pile, Kate Saunders, Peter Duquemin, David Brittain, Richard Cook, Marie Colvin, Greg Hadfield, Diana Wright, Brian Fallon, Craig Brown, Chris Horrie, Chris Partridge, Martin Dunkerton, Stephen Jones, John Prean, Meriel McCooey, Denis Filer, Richard Palmer, Robert Balchin, Christopher Huntington, Dick Kenny, Ian Birrell, Mervyn Matthews, Lt Cdr J H McGivering, Dilys Powell, Karen Armstrong, Ben Pimlott, Chris Jones, Andrew Hogg, Brough Scott, Zelda Hangum, David Selbourne, Caroline McGhie, Charles Qulton, Richard Woods, Peter Johnson, Marion Hume, Alan Green, Maurice Chittenden, Joy Melville, Ian Dunning, Felix Aprahamian, Brian MacArthur, Peter Chippindale, Michael Jones Political Editor, Roger Clarke, D J Taylor, M McCabe, Philip Beresford, R Anyon, F Pearce, Sue Thomas, Sir James Goldsmith, Mark Whitaker, Snoo Wilson, Charles Oulton, Boy George, Greg Hadfield Education Correspondent, Brian Glanville, Brian Clarke, Angus Roxburgh, Carmel McQuaid, Carrie Segrave, Edward Pearce, Simon Jenkins, Godfrey Golzen, Jon Craig Home Affairs Correspondent, Deirdre Fernand, Michael Berger, Nick Fielding, P Nash, George Steiner, Imre Karacs, Peter James, Robert Lee Morris, Ian Williams, John Marks, Anthony Delang, Valerie Grove, Chris Lightbown, Hugh Pearman, Marina Vaizey, Patricia A. Wilson, Margaret Park, Rosemary Collins, Angela Long, Germaine Greer, Martin Seymour-Smith, Dorothy Wade, Phillip Knightley, Tony Hetherington, Christopher Matthew, Jim Muir, Joanna Simon, Chris Blackhurst, Jack Clarke, Jon Connell, Georgina Howell, Jeff Randall Deputy City Editor,

... UN attack (Reuter): Passions run high at festival Nemeth: we were wrong ADT Auctions Ladbrokes To Cheltenham, ... Swan Hellenic Multiple Display Advertising Items Princess Voyages Ryan Hotel Group Chios Sunday Times Travel Brief B & ...

1989 - Gale Group | Sunday Times HA GDA

Artigo Revisado por pares

S. KLUTCHKO, M. L. HOEFLE, Ronald D. Smith, Arnold D. Essenburg, Robert B. Parker, Vicki L. Nemeth, Michael J. Ryan, Deborah H. Dugan, Harvey Kaplan,

A number of gamma- and delta-lactam derivatives were synthesized and their in vitro angiotensin-converting enzyme (ACE) inhibitory activities were compared. The structures of these compounds were designed to include many of the important features of captopril. The synthesis involved the preparation of a variety of novel 3-methylene-2-pyrrolidinones (3-5 and 16) and 3-methylene-2-piperidinones (3a-5a, 10-12, and 17). The key intermediate 3-methylenelactams 3 and 3a were obtained from 3-(hydroxymethyl) ...

Tópico(s): Chemical Reaction Mechanisms

1981 - American Chemical Society | Journal of Medicinal Chemistry

Jornais Acesso aberto

Widget Finn, Jon Ashworth, Freya Rowe and Lai Yahaya, Helen Johnstone, Nick Nuttall Environment Correspondent, John Birt, K. Natwar-Singh, Sam Kiley Africa Correspondent, Jeremy Laurance, John O'leary Education Correspondent, Jill Sherman Political Correspondent, Bill Frost, Andrew Longmore, Janet Bush, Economics Correspondent, Harvey Elliott, Sheila Gunn and Philip Webster, Tom Pocock, Ivo Tennant, Philip Howard, Ian Murray, Jeremy Kingston, Alexandra Frean Media Correspondent, Richard Green, Clive Davis, Carl Mortished, Dessa Trevisan, P. C. Matson, Nick Nuttall, Environment Correspondent, Edmund Latham, Stewart Tendler, Crime Correspondent, Tom Walker, Colin Narbrough, Martin Farndale, Geoff Brown, Eugene Onegin, John Rogers, Irwin Stelzer, Philip Bassett Industrial Editor, Joe Joseph, Thomas Sherwood, Stuart Jones, Simon D. Baggott, Terence Feely, Norman Hammond, Archaeology Correspondent, Martin Flanagan, Patricia Tehan, Raymond Keene Chess Correspondent, Richard Evans, Racing Correspondent, Reginald White, Peter Ackroyd, Matthew Parris Political Sketch, Al Green, Jeremy Laurance Health Services Correspondent, Alan Hamilton, Rodney Milnes, Louise Hidalgo, Robert Bruce, Philip Robinson, Anatole Kaletsky, Keith Pike, George Welham, Philip Willian and Ian Brodie, Charles Bremner, Ian McIntyre, Stuart Crainer, Michael Binyon Diplomatic Editor, Kate Muir, Susan Gilchrist, Edward Fennell, Nicole Swengley, Claire Messud, Colin Campbell Mining Correspondent, George Brock, Janet Daley, A. L. Rowse, Nicholas Wood Chief Political Correspondent, Anatole Kaletsky, Economics Editor, David Miller, Mark Almond, John Hopkins Golf Correspondent, G. T. Bosisto, Arthur Leathley and Robert Morgan, Jim Grear, Chairman, Robin Fitzsimons, David Powell Athletics Correspondent, Raymond Keene, Jonathan Prynn, Alan Lee, Cricket Correspondent, Libby MacNamara, Gordon Wilson, Frances Gibb, Legal Correspondent, Andrew Grossman, Philip Bassett and Jill Sherman, Nigel Hawkes, Alice Thomson, Barry Pickthall, Roddy Forsyth and Keith Pike, Erica Wagner, Stephanie Billen, Peter Taylor, Tony Rocca, Martin Waller, Deputy City Editor, H. Frith, William Rees-Mogg, Joanna Pitman, David Churchill, J. W. M. Thompson, Philip Webster Political Editor, Christopher Walker, Mel Webb, Gerald Larner, Margaret Hodge, H. Burns (Acting Director of Public Health), Sheila Gunn Political Correspondent, Stephen Bradshaw (Reporter), Helen Johnstone and Michael Dynes, Michael Hornsby, Robert Bourne, Alan Lee, C. J. F. Trott (Senior Consultant), Peter Riddell, Ian Brodie, Paul Barker, Richard Beeston, Ben Macintyre, Melinda Wittstock, Tania Glyde, Alec Reed, Benedict Nightingale, Tom Rhodes, Dr Thomas Stuttaford, Marianne Curphey, Frances Gibb Legal Correspondent, Paul Kelbie, Michael Evans Defence Correspondent, Sigmund Sternberg, Chairman, Anne McElvoy, Michael Evans, Andrew Finkel, John H. D. Heath, M. B. H. Ashmore, Michael Clarke, George Sivell City Editor, Stephen Stockwell, John Watson,

... global markets Time Computer Systems Ltd Picture Gallery Németh moves up running at EBRD Japan to cut ... Result from Yesterday's Four Meetings Rapid Raceline Ryan has change of heart over job Thunderer: Chepstow ...

1993 - Gale Group | TDA

Revisão Acesso aberto Revisado por pares

Paul C. Johnson,

... 163-169), Online publication date: 1-Dec-2020. Nemeth Z, Hildebrandt E, Ryan M, Granger J and Drummond H (2020) Pressure- ...

Tópico(s): Heart Rate Variability and Autonomic Control

1986 - Lippincott Williams & Wilkins | Circulation Research

Artigo Acesso aberto Revisado por pares

Walter Jetz, Grigori Tertitski, Roland Kays, Uschi Mueller, Martin Wikelski, Susanne Åkesson, Yury Anisimov, Aleksey Antonov, Walter Arnold, Franz Bairlein, Oriol Baltà, Diane Baum, Mario Beck, O. A. Belonovich, Mikhail Belyaev, Matthias Berger, Peter Berthold, Steffen Bittner, Stephen Blake, Barbara A. Block, Daniel A. F. Bloche, Katrin Boehning‐Gaese, Gil Bohrer, Julia Bojarinova, G. Bommas, O. V. Bourski, Albert Bragin, Alexandr Bragin, Rachel Bristol, Vojtěch Brlík, Victor N. Bulyuk, Francesca Cagnacci, Ben Carlson, Taylor K. Chapple, Kalkidan F. Chefira, Yachang Cheng, Nikita Chernetsov, Grzegorz Cierlik, Simon S. Christiansen, Oriol Clarabuch, William D. Cochran, Jamie M. Cornelius, Iain D. Couzin, Margret C. Crofoot, Sebastián Cruz, Alexander A. Davydov, Sarah C. Davidson, Stefan Dech, Dina K. N. Dechmann, E. Yu. Demidova, Jan Dettmann, Sven Dittmar, Dmitry Dorofeev, Detlev Drenckhahn, V. M. Dubyanskiy, Н. В. Егоров, Sophie Ehnbom, Diego Ellis‐Soto, R. Ewald, C. J. Feare, Igor Fefelov, Péter Fehérvári, Wolfgang Fiedler, Andrea Flack, Magnus Froböse, Ivan Fufachev, Pavel A. Futoran, Vyachaslav Gabyshev, Anna Gagliardo, Stefan Garthe, Sergey I. Gashkov, Luke Gibson, Wolfgang Goymann, Gerd Gruppe, Chris Guglielmo, Phil Hartl, Anders Hedenström, Arne Hegemann, Georg Heine, Mäggi Hieber Ruiz, Heribert Hofer, Felix Huber, Edward Hurme, Fabiola Iannarilli, Marc Illa, Arkadiy Isaev, Bent K. Jakobsen, Lukas Jenni, Susanne Jenni‐Eiermann, Brett R. Jesmer, Frédéric Jiguet, Tatiana Karimova, N. Jeremy Kasdin, Fedor Kazansky, Ruslan Kirillin, Thomas Klinner, Andreas Knopp, Andrea Kölzsch, Alexander Kondratyev, Marco Krondorf, Pavel Ktitorov, Olga V. Kulikova, Rahul Kumar, Claudia Künzer, Anatoliy Larionov, C. Larose, Félix Liechti, Nils Linek, Ashley Lohr, А. А. Лущекина, Kate Mansfield, М. В. Матанцева, Mikhail Markovets, Peter P. Marra, Juan F. Masello, Jörg Melzheimer, Myles H. M. Menz, Stephen Menzie, Swetlana Meshcheryagina, Dale G. Miquelle, Vladimir A. Morozov, Andrey Mukhin, Inge Müller, Thomas Mueller, Juan G. Navedo, Ran Nathan, L.S. Nelson, Zoltán Németh, Scott Newman, Ryan W. Norris, Olivier Nsengimana, И. М. Охлопков, Wioleta Oleś, Ruth Y. Oliver, Teague M. O'Mara, Péter Palatitz, Jesko Partecke, Ryan Pavlick, Anastasia Pedenko, Alys Perry, Julie Pham, Daniel Piechowski, Allison Pierce, Theunis Piersma, Wolfgang Pitz, Dirk Plettemeier, Irina D. Pokrovskaya, Liya Pokrovskaya, Ivan Pokrovsky, Morrison T. Pot, Petr Procházka, Petra Quillfeldt, Eldar Rakhimberdiev, Marilyn Ramenofsky, Ajay Ranipeta, Jan Rapczyński, Magdalena Remisiewicz, В. В. Рожнов, Froukje Rienks, В. В. Рожнов, Christian Rutz, В. В. Сахвон, Nir Sapir, Kamran Safi, Friedrich Schäuffelhut, David Schimel, Andreas Schmidt, Judy Shamoun‐Baranes, Alexander Sharikov, Laura Shearer, Evgeny Shemyakin, Sherub Sherub, J. Ryan Shipley, Yanina V. Sica, Thomas B. Smith, Sergey Simonov, Katherine R. S. Snell, Aleksandr Sokolov, Vasiliy Sokolov, Olga N Solomina, Mikhail Soloviev, Fernando Spina, Kamiel Spoelstra, Martin Storhas, Т. А. Свиридова, George W. Swenson, Phil Taylor, Kasper Thorup, Arseny Tsvey, Marlee A. Tucker, Sophie Tuppen, Woody Turner, Innocent Twizeyimana, Henk P. van der Jeugd, Louis van Schalkwyk, Mariëlle L. van Toor, Pauli Viljoen, Marcel E. Visser, Tamara Volkmer, А А Волков, С. В. Волков, O. N. Volkov, Jan A.C. von Rönn, Bernd Vorneweg, Bettina Wachter, Jonas Waldenström, Natalie Weber, Martin Wegmann, Aloysius Wehr, Rolf Weinzierl, Johannes Weppler, David S. Wilcove, Timm A. Wild, Hannah J. Williams, John H. Wilshire, John C. Wingfield, Michael B. Wunder, A. A. Yachmennikova, Scott W. Yanco, Elisabeth Yohannes, Amelie Zeller, Christian Ziegler, Anna Zięcik, Cheryl Zook,

Space-based tracking technology using low-cost miniature tags is now delivering data on fine-scale animal movement at near-global scale. Linked with remotely sensed environmental data, this offers a biological lens on habitat integrity and connectivity for conservation and human health; a global network of animal sentinels of environmental change.

Tópico(s): Marine animal studies overview

2022 - Elsevier BV | Trends in Ecology & Evolution

Carta Acesso aberto Revisado por pares

Luca Tóth, András Czigler, Nikolett Szarka, Péter Tóth,

... 10.1038/11086. Crossref | PubMed | ISI | Google Scholar5. Nemeth Z, Hildebrandt E, Ryan MJ, Granger JP, Drummond HA. Pressure-induced constriction ...

Tópico(s): S100 Proteins and Annexins

2020 - American Physical Society | AJP Heart and Circulatory Physiology

Artigo Revisado por pares

S. W. Kienzle, Michael W. Nemeth, J. M. Byrne, Ryan J. MacDonald,

The ACRU agro-hydrological modeling system provided the framework, containing code to simulate all major hydrological processes, including actual evapotranspiration estimates, to simulate the impacts of climate change in the Cline River watershed, Alberta, Canada, under historical (1961–1990) and a range of future climate conditions (2010–2039, 2040–2069, and 2070–2099). Whilst uncertainties in the estimation of many hydrological variables were inevitable, verification analyses carried out for the ...

Tópico(s): Climate variability and models

2011 - Elsevier BV | Journal of Hydrology

Artigo Acesso aberto Revisado por pares

Robert G. Miller, Gilbert Block, Jonathan Katz, Richard J. Barohn, Vidhya Gopalakrishnan, Merit Cudkowicz, Jane R. Zhang, Michael S. McGrath, Elizabeth Ludington, Stan H. Appel, Ari Azhir, Jonathan Katz, Giovanna Kushner, Cynthia Wong, Maguerite Engel, Dallas Forshew, Robert D. Osborne, Brooke Schug, Amy Akers, Bruce N. Brent, Thaïs Zayas-Bazan, Shelly McCoy, Neelam Goyal, Will Harris, Marie Gonella, Benjamin Rix Brooks, Elena Bravver, Mohammed Sanjak, Amber Ward, Amir Mehrizi, Mark Belfiore, Cynthia Lary, Joanne Nemeth, Jill Ker Conway, Ryan Bender, Scott Holsten, Jamie Shue, Hiroshi Mitsumoto, R. A. Youngman, Nicole M. Armstrong, Yei-won Lee, Louis H. Weimer, Thomas H. Brannagan, Michio Hirano, Marta Scotto, Kate Dalton, Richard Bedlack, Joel C. Morgenlander, Candace Lee Boyette, Karen Grace, Beth McLendon Arvik, Patrick Hickey, Burton Lasater Scott, Debra Lynn Heydt, Peggy Perry-Trice, Merit Cudkowicz, James Berry, Nazem Atassi, Khrista Boylan, Kathleen D. Kennelly, Pamela Desaro, Amelia Johnston, Angela Huser, Paula Fuqua, Kristin Staggs, Lorraine Babcock, Thomas B. Kryston, Mark A. Ross, E. Peter Bosch, Josephus L. Verheijde, Yvvonne Grover, Amy K. Duffy, Michael S. Lee, Roxanne R. McLaughlin, Danette J. Musil, Jennifer Early, Dana Whiteman, Joyce Wisbey, Ericka P. Simpson, Milvia Pleitez, Luis Lay, L. Halton Sharon, Thomas L. Schwartz, Linda Blanton, Eugene C. Lai, Erik P. Pioro, Rebecca Kuenzler, Nicole S. Berry, Sara Khan, Nabi Chowdhury, Julia Biernot, Kimberly Goslin, Gregory T. Carter, Patrick M. Corkrey, Miroslav Kovařík, Jeremy M. Shefner, Laura Simionescu, Megan Grosso, Mary Lou Watson, Melissa A. Reale, Anuradha Duleep, Robert Carhart, Katie Markis, Kristina Money, Travis Boevin, Neil Lava, Jonathan D. Glass, Meraida Polak, Latoya Shaw, Jane Bordeau, Susan Rogers, Susan Ferguson, Christina N. Fournier, Crystal Kelly, Tahseen Mozaffar, Annabel K. Wang, Gladys Ramsey, Patricia Tully, Michael C. Graves, Martina Wiedau‐Pazos, Rebecca Alvarez, Richard J. Barohn, April McVey, Mazen M. Dimachkie, Mamatha Pasnoor, Laura Herbelin, Maureen Walsh, Edward J. Kasarskis, William Dotson, Stephen Sitzlar, Tammy Tandy, Jeffery Carrico, Susan D. Phillips, Linda Rice, Kathryn M. Holbrook, David M. Eckmann, Lisa Chamblin, Janet M. Townsend, Janet Kaenzig, Lisa Hanley-Borgia, Kathryn E. Vanderpool, Deborah G. Taylor, Jessica M. Carpenter, Samantha Thomas, Jan Hutchinson, Jason T. King,

To assess the safety, tolerability, and preliminary efficacy of NP001, a novel immune regulator of inflammatory monocytes/macrophages, for slowing progression of amyotrophic lateral sclerosis (ALS).This was a phase 2 randomized, double-blind, placebo-controlled trial of NP001 in 136 patients with ALS of <3 years' duration and forced vital capacity ≥70%. Participants received NP001 2 mg/kg, NP001 1 mg/kg, or placebo for 6 months. Safety, tolerability, and inflammatory biomarkers were assessed throughout ...

Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms

2015 - Wolters Kluwer | Neurology Neuroimmunology & Neuroinflammation

Artigo Acesso aberto Revisado por pares

Zoltán Németh, Michael J. Ryan, Joey P. Granger, Heather A. Drummond,

Pressure-induced constriction (PIC) is inherent to small arteries and arterioles, in which intraluminal pressure-induced vascular smooth muscle cell stretch elicits vasoconstriction. Degenerin (Deg) proteins, such as beta-epithelial Na+ channel (βENaC), have been studied in the PIC response because they are evolutionarily linked to known mechanosensors. While loss of Deg function phenotypes are plentiful, a gain-of-function phenotype has not been studied. The aim of this study was to determine if expression ...

Tópico(s): Neuroscience and Neuropharmacology Research

2021 - Oxford University Press | American Journal of Hypertension

Artigo Acesso aberto Revisado por pares

David Ehrlich, Gretchen N. Neigh, Chase H. Bourke, Christina L. Nemeth, Rimi Hazra, Steven J. Ryan, Sydney A. Rowson, Nesha Jairam, Courtney R. Sholar, Donald G. Rainnie, Zachary N. Stowe, Michael J. Owens,

Depression during pregnancy has been linked to in utero stress and is associated with long-lasting symptoms in offspring, including anxiety, helplessness, attentional deficits, and social withdrawal. Depression is diagnosed in 10–20% of expectant mothers, but the impact of antidepressant treatment on offspring development is not well documented, particularly for females. Here, we used a prenatal stress model of maternal depression to test the hypothesis that in utero antidepressant treatment could ...

Tópico(s): Stress Responses and Cortisol

2015 - Elsevier BV | Neuropharmacology

Artigo Acesso aberto Revisado por pares

Zoltán Németh, Emily Hildebrandt, Michael J. Ryan, Joey P. Granger, Heather A. Drummond,

Pressure-induced constriction (PIC) is an inherent response of small arteries and arterioles in which increases in intraluminal pressure evoke vasoconstriction. It is a critical mechanism of blood flow autoregulation in the kidney and brain. Degenerin (Deg) and transient receptor potential (Trp) protein families have been implicated in transduction of PIC because of evolutionary links to mechanosensing in the nematode and fly. While TrpC6 has been suggested to contribute to PIC signaling, direct supporting ...

Tópico(s): Ion channel regulation and function

2020 - American Physical Society | AJP Heart and Circulatory Physiology

Artigo Acesso aberto Revisado por pares

Roy A. Armstrong, Hanumant Singh, Juan Antonio Torres, Richard S. Nemeth, Ali Can, Chris Roman, Ryan M. Eustice, Lauren Riggs, Graciela García‐Moliner,

The benthic communities of the deep insular shelf at the Hind Bank marine conservation district (MCD), an important spawning aggregation site for groupers, were studied with the Seabed autonomous underwater vehicle (AUV) at depths between 32 and 54 m. Four digital phototransects provided data on benthic species composition and abundance of the insular shelf off St. Thomas, US Virgin Islands. Within the western side of the MCD, well-developed coral reefs with 43% mean living coral cover were found. ...

Tópico(s): Marine Biology and Ecology Research

2006 - Elsevier BV | Continental Shelf Research

Artigo Acesso aberto Revisado por pares

George Papanikolaou, Mark Samuels, E H Ludwig, Marcia L.E. MacDonald, Patrick L. Franchini, Marie‐Pierre Dubé, Lisa Andres, Julie MacFarlane, Nikos Sakellaropoulos, Marianna Politou, Elizabeta Nemeth, Jay Thompson, Jenni Risler, Catherine Zaborowska, Ryan Babakaiff, Christopher C Radomski, Terry D. Pape, Owen Davidas, John Christakis, Pierre Brissot, Gillian Lockitch, Tomas Ganz, Michael R. Hayden, Y. Paul Goldberg,

Juvenile hemochromatosis is an early-onset autosomal recessive disorder of iron overload resulting in cardiomyopathy, diabetes and hypogonadism that presents in the teens and early 20s (refs. 1,2). Juvenile hemochromatosis has previously been linked to the centromeric region of chromosome 1q (refs. 3-6), a region that is incomplete in the human genome assembly. Here we report the positional cloning of the locus associated with juvenile hemochromatosis and the identification of a new gene crucial to ...

Tópico(s): Trace Elements in Health

2003 - Nature Portfolio | Nature Genetics

Artigo Revisado por pares

M. Chernos, Ryan J. MacDonald, Michael W. Nemeth, James R. Craig,

The Athabasca River Basin in Alberta, Canada, is of international significance, and understanding water supply is critically important to the sustainability of the region. In the upper Athabasca River Basin, glaciers covered 272 km2 (2.8% of the watershed) as of 2010, but less than 50 km2 are projected to remain by the end of the twenty-first century. This study investigated glacier contributions to streamflow for a baseline (1981–2010) period and two climate change scenarios (RCP 4.5 and RCP 8.5, ...

Tópico(s): Climate change and permafrost

2020 - Taylor & Francis | Canadian Water Resources Journal / Revue canadienne des ressources hydriques

Artigo Acesso aberto

David Cohen, Dale B. Evans, Michael J. Ryan, Harvey Kaplan,

... R. D., Essenburg, A. D., Parker, R. B., Nemeth, V. L., Ryan, M. J., Dugan, D. H., and Kaplan, H. ...

Tópico(s): Cancer Treatment and Pharmacology

1985 - Wiley | Cardiovascular Drug Reviews

Artigo Revisado por pares

Zoltán Németh, Ryan H. Adams, Marilyn Ramenofsky,

Gonadal steroid hormones enhance cognitive performance, particularly spatial and vocal learning, in mammals and birds. However, it is unknown whether problem-solving ability is similarly regulated. We propose that androgens, such as testosterone and 5α-dihydrotestosterone, play a role in mediating problem-solving behavior as well. As a test, male white-crowned sparrows (Zonotrichia leucophrys gambelii) were either castrated and administered a blank (Blank-castrate) or testosterone-filled implant (T- ...

Tópico(s): Avian ecology and behavior

2015 - Wiley | Ethology

Artigo Revisado por pares

Mary Ryan, Diane Petrone, Jennifer F. Nemeth, Evan Barnathan, Lars Björck, Robert E. Jordan,

A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A majority of the identified proteinases converted IgG to F(ab')(2), and a consistent feature of their action was a transient accumulation of a single-cleaved intermediate (scIgG). The scIgG resulted from the relatively rapid ...

Tópico(s): Protein purification and stability

2007 - Elsevier BV | Molecular Immunology

Artigo Acesso aberto Revisado por pares

Benjamin C. Nephew, Alexandra Németh, Neelakshi Hudda, Gillian Beamer, Phyllis E. Mann, Jocelyn Petitto, Ryan J. Cali, Marcelo Febo, Praveen Kulkarni, Guillaume L. Poirier, Jean A. King, John L. Durant, Doug Brugge,

Recent studies indicate that exposure to airborne particulate matter (PM) is associated with cognitive delay, depression, anxiety, autism, and neurodegenerative diseases; however, the role of PM in the etiology of these outcomes is not well-understood. Therefore, there is a need for controlled animal studies to better elucidate the causes and mechanisms by which PM impacts these health outcomes. We assessed the effects of gestational and early life exposure to traffic-related PM on social- and anxiety- ...

Tópico(s): Noise Effects and Management

2020 - Elsevier BV | Environmental Research

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Paul C. Adams, Albert Altés, Pierre Brissot, Barbara Butzeck, Ioav Cabantchik, Rodolfo Delfini Cançado, S Distante, Patricia Evans, Robert M. Evans, Tomas Ganz, Domenico Girelli, Rolf Hultcrantz, Gordon D. McLaren, Ben Marris, Nils Milman, Elizabeta Nemeth, Peter Nielsen, Brigitte Pineau, Alberto Piperno, Graça Porto, Dianne Prince, John Ryan, Mayka Sánchez, Paulo Caleb Júnior Lima Santos, Dorine W. Swinkels, Emerência Teixeira, Ketil Toska, Annick Vanclooster, Desley White,

Although guidelines are available for hereditary hemochromatosis, a high percentage of the recommendations within them are not shared between the different guidelines. Our main aim is to provide an objective, simple, brief, and practical set of recommendations about therapeutic aspects of HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype, based on the published scientific studies and guidelines, in a form that is reasonably comprehensible to patients and people without medical ...

Tópico(s): Plant Micronutrient Interactions and Effects

2018 - Springer Science+Business Media | Hepatology International

Capítulo de livro Revisado por pares

Andre Broido, Ryan King, Evi Nemeth, kc claffy,

Abstract We demonstrate the feasibility of Internet spectroscopy techniques for analysis of rate limiting, packet interarrival delay and passive bitrate estimation of cell-or slot-based broadband connections. Working with highly diverse packet trace data, we find that delay's quantization in micro- and millisecond range is ubiquitous in today's Internet and that different providers have strong preferences for specific delay quanta in their infrastructures.

Tópico(s): Interconnection Networks and Systems

2003 - Elsevier BV | Teletraffic science and engineering

Artigo Acesso aberto Revisado por pares

Kelly Vaez, Lauren Diegel-Vacek, Catherine Ryan, Pamela Martyn‐Nemeth,

People with serious mental illness (SMI) have a higher incidence of type 2 diabetes mellitus (T2DM) and shorter life span due to medical health problems. The chronic care model (CCM) has been used to improve care of patients with T2DM. One clinical organization that provided primary care to patients with SMI had excellent diabetes outcomes but did not have information on how they achieved those outcomes. Thus, we conducted a pilot study chart review for 30 patients with T2DM and SMI to determine how ...

Tópico(s): Schizophrenia research and treatment

2017 - SAGE Publishing | Health Services Research and Managerial Epidemiology

Artigo Acesso aberto Revisado por pares

Mandeep Kaur, Adam Drake, Guangan Hu, Stephen I. Rudnick, Qingfeng Chen, Ryan Phennicie, Ricardo M. Attar, Jeffrey A. Nemeth, François Gaudet, Jianzhu Chen,

Abstract Development of targeted cancer therapy requires a thorough understanding of mechanisms of tumorigenesis as well as mechanisms of action of therapeutics. This is challenging because by the time patients are diagnosed with cancer, early events of tumorigenesis have already taken place. Similarly, development of cancer immunotherapies is hampered by a lack of appropriate small animal models with autologous human tumor and immune system. In this article, we report the development of a mouse ...

Tópico(s): CAR-T cell therapy research

2019 - American Association of Immunologists | The Journal of Immunology

Artigo

Simin Florescu, Delia Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Aneela Kidwai, Sobia Masood, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, János Bélteczki, István Magyar, Ágnes Fazekas, Sándor Kovács, Viktória Szőke, Adrian Donnelly, Martin Kelly, Naoise Smyth, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Geri, Antoine Vieillard-Baron, Paul Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C Vignesh, Bharath TV, N Ramakrishnan, Augustian James, Evangeline Elvira, Devachandran Jayakumar, Ramachandran Pratheema, Suresh Babu, R Ebenezer, S Krishnaoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Eileen Guilder, Magdalena Butler, Keri-Anne Cowdrey, Melissa Robertson, Farisha Ali, Ellie McMahon, Eamon Duffy, Yan Chen, Catherine Simmonds, Rachael McConnochie, Caroline O’Connor, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Manoj Saxena, Margaret Muteithia, Kelsey Dobell‐Brown, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick J. Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kate A. Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Cameron Knott, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Latesh Poojara, Treena Sara, Kiran Nand, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Julia Affleck, Arif Shaikh, Andrew Murray, Mahesh Ramanan, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Ritesh Sanghavi, Deepak Bhonagiri, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Bree McDonald, Natasha Edmunds, Oscar Hoiting, Marco Peters, Els Rengers, Mirjam Evers, Anton Prinssen, Matt Morgan, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Pierre Declerq, Antoine Marchalot, Stéphanie Gélinotte, Eraldi Jean-Pierre, Bourgerol François, Beuzelin Marion, Rigaud Philippe, Franck Pourcine, Mehran Monchi, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeu, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick D’Aragon, Élaine Carbonneau, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, François Martin Carrier, Dounia Boumahni, Fatna Benettaib, Ali Ghamraoui, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel, David Antcliffe, Maie Templeton, Roceld Rojo, Phoebe Coghlan, Joanna Smee, Gareth J. Barker, André Finn, Gabriele Kreb, Uwe Hoff, Carl Hinrichs, Jens Nee, Euan Mackay, Jon Cort, Amanda Whileman, Thomas E. Spencer, Nick Spittle, Sarah Beavis, Anand Padmakumar, Katie Dale, Joanne Hawes, Emma Moakes, Rachel Gascoyne, Kelly Pritchard, Lesley Stevenson, Justin Cooke, Karolina Nemeth-Roszpopa, Basanta Gauli, Sirjana Bastola, Grégoire Müller, Mai-Anh Nay, Toufik Kamel, Dalila Benzekri, Sophie Jacquier, Isabelle Runge, Armelle Mathonnet, François Barbier, Anne Bretagnol, Jay Carter, Kymbalee Van Der Heyden, Jan Mehrtens, Anna Morris, Stacey Morgan, Tara Burke, Emmanuelle Mercier, Delphine Chartier, Charlotte Salmon, Pierre‐François Dequin, Denis Garot, David Bellemare, Ève Cloutier, Rana Daher, Olivier Costerousse, Marie-Claude Boulanger, Émilie Couillard-Chénard, François Lauzier, Charles Francoeur, Bruno François, Alexandra Gay, Fedou Anne-Laure, Mohamed Ramali, Ooi HC, Alison Ghosh, Rawlings Osagie, Malka Arachchige, Melissa D. Hartley, Winston Cheung, Helen Wong, Patrick Seigne, Joe Eustace, Annmarie O’Callaghan, Fionnuala O'Brien,

The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.

American Medical Association

Artigo

Simin Florescu, Delia Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Aneela Kidwai, Sobia Masood, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, János Bélteczki, István Magyar, Ágnes Fazekas, Sándor Kovács, Viktória Szőke, Adrian Donnelly, Martin Kelly, Beverley J. Hunt, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Geri, Antoine Vieillard-Baron, Paul Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C Vignesh, Bharath TV, N Ramakrishnan, Augustian James, Evangeline Elvira, Devachandran Jayakumar, Pratheema Ramachandran, Suresh Babu, R Ebenezer, S Krishnaoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Eileen Guilder, Magdalena Butler, Keri-Anne Cowdrey, Melissa Robertson, Farisha Ali, Ellie McMahon, Eamon Duffy, Yan Chen, Catherine Simmonds, Rachael McConnochie, Caroline O’Connor, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kate A. Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Cameron Knott, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Julia Affleck, Yogesh Apte, Umesh Subbanna, Roland Bartholdy, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Karuna Keat, Deepak Bhonagiri, Ritesh Sanghavi, Jodie Nema, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Oscar Hoiting, Marco Peters, Els Rengers, Mirjam Evers, Anton Prinssen, Morgan Matt, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Pierre Declerq, Antoine Marchalot, Stéphanie Gélinotte, Eraldi Jean-Pierre, Bourgerol François, Beuzelin Marion, Rigaud Philippe, Franck Pourcine, Mehran Monchi, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeu, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick Carbonneau, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, François Martin Carrier, Dounia Boumahni, Fatna Benettaib, Ali Ghamraoui, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel, David Antcliffe, Maie Templeton, Roceld Rojo, Phoebe Coghlan, Joanna Smee, Gareth J. Barker, André Finn, Gabriele Kreß, Uwe Hoff, Carl Hinrichs, Jens Nee, Euan Mackay, Jon Cort, Amanda Whileman, Thomas E. Spencer, Nick Spittle, Sarah Beavis, Anand Padmakumar, Katie Dale, Joanne Hawes, Emma Moakes, Rachel Gascoyne, Kelly Pritchard, Lesley Stevenson, Justin Cooke, Karolina Nemeth-Roszpopa, Basanta Gauli, Sirjana Bastola, Grégoire Müller, Mai-Anh Nay, Toufik Kamel, Dalila Benzekri, Sophie Jacquier, Isabelle Runge, Armelle Mathonnet, François Barbier, Anne Bretagnol, Jay Carter, Kymbalee Van Der Heyden, Jan Mehrtens, Anna Morris, Stacey Morgan, Tara Burke, Emmanuelle Mercier, Delphine Chartier, Charlotte Salmon, Pierre‐François Dequin, Denis Garot, David Bellemare, Ève Cloutier, Rana Daher, Olivier Costerousse, Marie-Claude Boulanger, Émilie Couillard-Chénard, François Francoeur, Bruno François, Alexandra Gay, Fedou Anne-Laure, Mohamed Ramali, Ooi HC, Alison Ghosh, Rawlings Osagie, Malka Arachchige, Melissa D. Hartley, Winston Cheung, Mark Kol, Helen Wong, Asim A. Shah, Atul Wagh, Peter Bamford, Andrew Reid, Kathryn Cawley, Maria Faulkner, Charlotte Pickering, Ashok Raj, Georgios Tsinaslanidis, Reena Khade, Gloria Agha,

Importance The efficacy of antiplatelet therapy in critically ill patients with COVID-19 is uncertain. Objective To determine whether antiplatelet therapy improves outcomes for critically ill adults with COVID-19. Design, Setting, and Participants In an ongoing adaptive platform trial (REMAP-CAP) testing multiple interventions within multiple therapeutic domains, 1557 critically ill adult patients with COVID-19 were enrolled between October 30, 2020, and June 23, 2021, from 105 sites in 8 countries and followed ...

American Medical Association

Artigo

Simin Aysel Florescu, Dragos Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Komal Fareed, Aneela Kidwai, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, David Sapsford, Katherine Bongaerts, Peter J Featherstone, Anthony Ng, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, Adrian Donnelly, Martin Kelly, Naoise Smyth, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Géri, Antoine Vieillard-Baron, Paul D. R. Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C. Vignesh, Nagarajan Ramakrishnan, Augustian James, Evangeline Elvira, Pratheema Ramachandran, Suresh Babu, Rabindrarajan Ebenezer, Sarayu Krishnamoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Simone Piva, Emanuele Focà, Damiano Rizzoni, Gianluca E.M. Boari, Mattia Marchesi, Magdalena Butler, Keri-Anne Cowdrey, Brittany L. Mason, Melissa Woolett, Eamon Duffy, Yan Chen, Hiromi Nakamuro, Caroline O’Connor, Lauren West, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Manoj Saxena, Margaret Muteithia, Kelsey Dobell‐Brown, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick J. Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kate A. Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Emmet Major, Julie McAuley, Angus Carter, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Latesh Poojara, Treena Sara, Kiran Nand, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Marion Campbell, Filipa Santos, Dan Hansen, Dee Mullan, Julia Affleck, Arif Shaikh, Andrew Murray, Mahesh Ramanan, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Ritesh Sanghavi, Deepak Bhonagiri, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Bree McDonald, Natasha Edmunds, Oscar Hoiting, Marco Peters, Els Rengers, Manon Bindels, Mirjam Evers, Anton Prinssen, Morgan Matt, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, D. C. Law, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Adrien Auvet, Celine Ravry, Vanessa Creange, Anne-Hélène Boivin, Amélie Barreau, Sophie Vandewoestyne, Pierre-Louis Declercq, Antoine Marchalot, Cécile Saladin, Stéphanie Gelinotte, Jean-Pierre Eraldi, François Bourgerol, Marion Beuzelin, Rigaud Jean-Philippe, Franck Pourcine, Mehran Monchi, Gaël Pradel, Marie-Helene Hausermann, Michel Boudineau, Thi-My-Hue Nguyen-Valat, Christophe Guitton, Rémy Marnai, Marie-Hélène Leroyer, Michaël Landais, Cédric Darreau, Marjorie Saint Martin, Patrice Tirot, Nicolas Chudeau, Aurélie Brasselet, Lev Volkov, Jean-Christophe Callahan, Juliette Meunier, Thomas Douillard, Elliot Le Basnier, Marion Veillard, Dominique Vivier, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeur, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick D’Aragon, Dominique Bérard, Brian Grondin-Beaudoin, Marc-André Leclair, Olivier Lesur, Michaël Mayette, Yannick Poulin, Hector Quiroz-Martinez, Charles St-Arnaud, Élaine Carbonneau, Brigitte Bolduc, Julie Bélisle, Marie-Pier Bouchard, Line Côté, Joannie Martineau, Alexandra Naisby, Louise Robert-Petit, Marie-Ève Thibault, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, Aslanian Pierre, Sylvain Bélisle, François Martin Carrier, Emmanuel Charbonney, Martin Girard, Jean-Gilles Guimond, Antoine Halwagi, Christophe Kolan, Nicholas Robillard, Dounia Boumahni, Fatna Benettaib, M Cantin, Katherine Coutu-Beaudry, Ali Ghamraoui, F Lamothe, Martine Lebrasseur, Cindy Prié, Maya Salamé, Patrick Archambault, Émilie Côté, Rosalie Beaudoin, Monia Noël-Hunter, Mireille Boutin, Laurie Couture, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre-Yves Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel,

The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.

American Medical Association

Artigo

Simin Aysel Florescu, Dragos Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Komal Fareed, Aneela Kidwai, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, David Sapsford, Katherine Bongaerts, Peter J Featherstone, Anthony Ng, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, Adrian Donnelly, Martin Kelly, Naoise Smyth, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Géri, Antoine Vieillard‐Baron, Paul D. R. Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C. Vignesh, Nagarajan Ramakrishnan, Augustian James, Evangeline Elvira, Ramachandran Pratheema, Suresh Babu, Rabindrarajan Ebenezer, Sarayu Krishnamoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Simone Piva, Emanuele Focà, Damiano Rizzoni, Gianluca E.M. Boari, Mattia Marchesi, Magdalena Butler, Keri-Anne Cowdrey, Brittany L. Mason, Melissa Woolett, Eamon Duffy, Yan Chen, Hiromi Nakamuro, Caroline O’Connor, Lauren West, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Manoj Saxena, Margaret Muteithia, Kelsey Dobell‐Brown, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kathryn Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Emmet Major, Julie McAuley, Angus Carter, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Latesh Poojara, Treena Sara, Kiran Nand, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Marion Campbell, Filipa Santos, Dan Hansen, Dee Mullan, Julia Affleck, Arif Shaikh, Andrew Murray, Mahesh Ramanan, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Ritesh Sanghavi, Deepak Bhonagiri, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Bree McDonald, Natasha Edmunds, Oscar Hoiting, Marco Peters, Els Rengers, Manon Bindels, Mirjam Evers, Anton Prinssen, Matt Morgan, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, D. C. Law, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Adrien Auvet, Celine Ravry, Vanessa Creange, Anne-Hélène Boivin, Amélie Barreau, Sophie Vandewoestyne, Pierre-Louis Declercq, Antoine Marchalot, Cécile Saladin, Stéphanie Gelinotte, Jean-Pierre Eraldi, François Bourgerol, Marion Beuzelin, Rigaud Jean-Philippe, Franck Pourcine, Mehran Monchi, Gaël Pradel, Marie-Helene Hausermann, Michel Boudineau, Thi-My-Hue Nguyen-Valat, Christophe Guitton, Rémy Marnai, Marie-Hélène Leroyer, Michaël Landais, Cédric Darreau, Marjorie Saint Martin, Patrice Tirot, Nicolas Chudeau, Aurélie Brasselet, Lev Volkov, Jean-Christophe Callahan, Juliette Meunier, Thomas Douillard, Elliot Le Basnier, Marion Veillard, Dominique Vivier, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeur, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick D’Aragon, Dominique Bérard, Brian Grondin-Beaudoin, Marc-André Leclair, Olivier Lesur, Michaël Mayette, Yannick Poulin, Hector Quiroz-Martinez, Charles St-Arnaud, Élaine Carbonneau, Brigitte Bolduc, Julie Bélisle, Marie-Pier Bouchard, Line Côté, Joannie Martineau, Alexandra Naisby, Louise Robert-Petit, Marie-Ève Thibault, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, Aslanian Pierre, Sylvain Bélisle, François Martin Carrier, Emmanuel Charbonney, Martin Girard, Jean-Gilles Guimond, Antoine Halwagi, Christophe Kolan, Nicholas Robillard, Dounia Boumahni, Fatna Benettaib, M Cantin, Katherine Coutu-Beaudry, Ali Ghamraoui, F Lamothe, Martine Lebrasseur, Cindy Prié, Maya Salamé, Patrick Archambault, Émilie Côté, Rosalie Beaudoin, Monia Noël-Hunter, Mireille Boutin, Laurie Couture, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre-Yves Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel,

Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.

American Medical Association