Kozo Fujiwara, Ryoichi Maeda, Kensaku Maeda, Haruhiko Morito,
Twin boundary formation at grain boundaries in multicrystalline Si during directional solidification was investigated by in situ observation of the crystal/melt interface. It was clearly shown that a twin boundary was formed on the {111} facet of grain-boundary groove at the crystal/melt interface. The large amount of undercooling in the melt at grain-boundary grooves promoted rapid crystallization and twin boundary formation.
Tópico(s): Microstructure and mechanical properties
2017 - Elsevier BV | Scripta Materialia
Masahiko Kondo, Shuji Kimura, Izuho Hirano, Youichi Uraki, Ryoichi Maeda,
The DI diesel engine has an advantage in terms of fuel economy, but disadvantages with respect to exhaust emissions and large combustion noise. To overcome these drawbacks, we have previously proposed the Modulated Kinetics (MK) concept [1], [2] of low-temperature, premixed combustion. This paper presents the results of an investigation into the potential of a new combustion system to reduce combustion noise and improve emission performance simultaneously. As a result of applying heavy EGR and retarding ...
Tópico(s): Combustion and flame dynamics
2000 - Elsevier BV | JSAE Review
Tsutomu Fukuda, Ryoichi Maeda, Masatomo Iwao,
Directed lithiation of 1-acylindole derivatives was investigated. It was discovered that a bulky 2,2-diethylbutanoyl (DEB) group could promote unusual C-7 lithiation. Especially in the case of 3-substituted 1-(DEB)indoles, selective C-7 lithiation was achieved in a synthetically useful level. The DEB group was readily removed by H2O/tert-BuOK/THF system after functionalization at C-7. This, therefore, allows easy generation of 3,7-disubstituted indole derivatives which are not readily available by ...
Tópico(s): Chemical Reaction Mechanisms
1999 - Elsevier BV | Tetrahedron
Akikazu Kakehi, Suketaka Ito, Toshiaki Maeda, Ryoichi Takeda, Masao Nishimura, Masato Tamashima, Tetsuya Yamaguchi,
... methods for indolizine derivativesAkikazu Kakehi, Suketaka Ito, Toshiaki Maeda, Ryoichi Takeda, Masao Nishimura, Masato Tamashima, and Tetsuya YamaguchiCite ...
Tópico(s): Chemical synthesis and alkaloids
1978 - American Chemical Society | The Journal of Organic Chemistry
Takenori Ishikawa, Kazuo Murakami, Ryoichi Yasui, Kohsaku Maeda, Kohji Tanaka, Tsunehiro SHIMOSATO,
A case is reported of schwannoma of the right masseteric nerve, invading the pterygopalatine fossa and the parapharyngeal space through the mandibular notch in a 61-year-old woman. The tumor in this case was composed of four various-sized interconnected nodules, simulating a string of beads. The tumor was the cause of the patient's chronic hemicrania, as confirmed by the relief from and disappearance of head pain after surgical removal of the tumor. The most important aspects of this case are the ...
Tópico(s): Bone Tumor Diagnosis and Treatments
1991 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology
Shinichi Miyagawa, Ryuji Kamata, Koki Matsumoto, Ryoichi Okamura, Hiroshi Maeda,
Tópico(s): Ocular Infections and Treatments
1991 - Springer Science+Business Media | Graefe s Archive for Clinical and Experimental Ophthalmology
Shinichi Miyagawa, Norikazu Nishino, Ryuji Kamata, Ryoichi Okamura, Hiroshi Maeda,
The growth inhibitory effects of chicken egg white ovomacroglobulin (ovoM) on Serratia marcescens and Pseudomonas aeruginosa were studied. The growth of protease-producing strains was greater than that of the strains producing little protease, and was inhibited in a dose-dependent manner by ovoM, a potent protease inhibitor. Dose-dependent enhancement of growth of strains of S. marcescens and P. aeruginosa that produce little protease was observed with the medium treated with proteases. These results ...
Tópico(s): Silk-based biomaterials and applications
1991 - Elsevier BV | Microbial Pathogenesis
Masanobu Tani, Tsuyoshi Aoki, Sadao ITO, Shigenobu Matsumoto, Mami HIDESHIMA, Kaoru FUKUSHIMA, Ryoichi NOZAWA, Takako MAEDA, M. TASHIRO, Yuusaku Yokoyama, Yasuoki Murakami,
The Friedel-Crafts acylation of ethyl 1H-indole-2-carboxylate (1) with various acylating reagents having a functional group or hetero atom and the acylation of some derivatives (6, 7, 8, and 9) of ethyl 1H-indole-2-carboxylate (1) with simple acylating reagents are described. Acylation occurred at the C3-position or on the benzene moiety (mainly at the C5-position) of the indole nucleus. The regioselectivity of the above acylation of indoles (1, 6, 7, 8, and 9) is discussed.
Tópico(s): Synthesis and Biological Evaluation
1990 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Arun K. Iyer, Khaled Greish, Jun Fang, Ryoichi Murakami, Hiroshi Maeda,
Tópico(s): Neonatal Health and Biochemistry
2006 - Elsevier BV | Biomaterials
Tomomi Ishimaru, Yoshimi Shioya, Hiroshi Ikakura, Mamoru Nozawa, Shoji Ohgawara, Toshiyuki Ohdaira, Ryoichi Suzuki, Kazuo Maeda,
We have successfully developed the barrier SiOCH film for copper thermal diffusion by plasma-enhanced chemical vapor deposition (PECVD) using hexamethyldisiloxane (HMDSO) and nitrous oxide We attempted to lower the k value and the leakage current by adding oxygen into the barrier silicon carbide (SiC) film. The film can protect Cu thermal diffusion at 450°C for 4 h in nitrogen The k value is lower than that for PECVD silicon nitride (SiN) and SiC films, and is almost the same as that of PECVD silicon ...
Tópico(s): Semiconductor materials and interfaces
2003 - Institute of Physics | Journal of The Electrochemical Society
Hisako Matsumoto, Keiichiro Suzuki, K Tsuyuguchi, Eisaku Tanaka, Ryoichi Amitani, Akito Maeda, K. Yamamoto, Masataka Sasada, F Kuze,
Macrophage-derived interleukin-12 (IL-12) is essential for the activation of a protective immune response against intracellular pathogens. In this study, we examined the regulation of IL-12 mRNA expression by monocyte-derived macrophages (MDM) in response to Mycobacterium bovis BCG stimulation. A reverse transcription-PCR assay detected p40 mRNA of IL-12 at 3 h and showed a peak at 6 to 12 h with a subsequent decline. Semiquantitation of mRNA levels by competitive PCR revealed that pretreatment with ...
Tópico(s): Immunotherapy and Immune Responses
1997 - American Society for Microbiology | Infection and Immunity
Masaki Suemura, Hitoshi Kikutani, E L Barsumian, Yuki Hattori, Shinji Kishimoto, Ryoichi Sato, Akito Maeda, Hiroshige Nakamura, Hajime Owaki, Richard R. Hardy,
Three monoclonal antibodies, 1-7 (gamma 2b), 3-5 (gamma 1), and 8-30 (mu), specific to Fc epsilon receptors (Fc epsilon R) on human B cells were established. The two monoclonals (1-7 and 8-30) could inhibit the binding of IgE to Fc epsilon R in rosette formation assays, as well as FACS analysis, and were shown to recognize the same epitope of Fc epsilon R. The other monoclonal antibody (3-5) recognized the same molecule but a different epitope, and marginally inhibited the IgE binding. The molecules on ...
Tópico(s): Asthma and respiratory diseases
1986 - American Association of Immunologists | The Journal of Immunology
M. Haisa, S. Kashino, Ryoichi Kawai, H. Maeda,
Tópico(s): Chemical Synthesis and Reactions
1976 - International Union of Crystallography | Acta Crystallographica Section B
Svyatoslav Gnyloskurenko, Takashi Nakamura, A. V. Byakova, Yu. М. Podrezov, Ryoichi Ishikawa, Minoru Maeda,
A most promising lightweight material termed cellular metal is of growing interest to industry because of its combination of strength and energy absorption. A new foaming agent, calcium carbonate, along with an appropriate technique are suggested to improve the metal structure and control the foaming process. An applied coating enhances wetting of the agent particles and improves the homogeneity of the foam. Structure and mechanical properties of the foams obtained were also studied. The results ...
Tópico(s): Cellular and Composite Structures
2005 - Taylor & Francis | Canadian Metallurgical Quarterly
Shinichi Miyagawa, Ryuji Kamata, Koki Matsumoto, Ryoichi Okamura, Hiroshi Maeda,
Tópico(s): Bacterial biofilms and quorum sensing
1994 - Springer Science+Business Media | Graefe s Archive for Clinical and Experimental Ophthalmology
Yumi Takiyama, Toshihiro Sera, Masanori Nakamura, Kanaki Ishizeki, Yasuaki Saijo, Tsuyoshi Yanagimachi, Manami Maeda, Ryoichi Bessho, Takao Takiyama, Hiroya Kitsunai, Hidemitsu Sakagami, Daisuke Fujishiro, Yukihiro Fujita, Yuichi Makino, Atsuko Abiko, Masato Hoshino, Kentaro Uesugi, Naoto Yagi, Tsuguhito Ota, Masakazu Haneda,
Recent large-scale clinical studies demonstrate that sodium-glucose cotransporter 2 (SGLT2) inhibitors protect the diabetic kidney. However, clinical and animal studies have not shown the changes of the total glomeruli in the whole kidney treated with SGLT2 inhibitors.
Tópico(s): Pancreatic function and diabetes
2018 - Elsevier BV | EBioMedicine
Gene Kurosawa, Mariko Sumitomo, Yoshinori Ukai, Juvy Subere, Chiho Muramatsu, Keiko Eguchi, Miho Tanaka‐Hashiba, Mai Sugiura, Misaki Ando, Noriko Sato, Miwa Morita, Kazuki Inaba, Satoko Morigaki, Akihiko Takasaki, Yasushi Akahori, Shuichi Miyakawa, Ichiro Uyama, Koutarou Maeda, Ryoichi Shiroki, Kiyotaka Hoshinaga, Yoshikazu Mizoguchi, Yoshinobu Hattori, Atsushi Sugioka, Mototaka Sugiura, Yoshikazu Kurosawa,
The search for effective antibodies (Ab) for curable cancer immunotherapy has been a quest of many research groups in order to find an effective target that exists on the cancer cell surface. So far there have been no conclusive answers to shed light on the search. This study therefore aimed to bridge the gap of cancer therapy. Screening against 49 kinds of cell lines belonging to 11 kinds of solids cancers was performed. Isolation and characterization for approximately 4200 monoclonal antibodies ( ...
Tópico(s): HER2/EGFR in Cancer Research
2010 - Wiley | Cancer Science
Norihiro Okamoto, Koutarou Maeda, Ryoichi Kato, Shyoshi Senga, Harunobu Sato, Ryuji Hosono,
Tópico(s): Pelvic and Acetabular Injuries
2006 - Springer Science+Business Media | Journal of Gastroenterology
Naotada Ishihara, Masatoshi Nomura, Akihiro Jofuku, Hiroki Kato, Satoshi O. Suzuki, Keiji Masuda, Hidenori Otera, Yae Nakanishi, Ikuya Nonaka, Yu-ichi Goto, Naoko Taguchi, Hidetaka Morinaga, Maki Maeda, Ryoichi Takayanagi, Sadaki Yokota, Katsuyoshi Mihara,
Tópico(s): Cell death mechanisms and regulation
2009 - Nature Portfolio | Nature Cell Biology
Yoshimi Shioya, Tomomi Ishimaru, Hiroshi Ikakura, Yuko Nishimoto, Toshiyuki Ohdaira, Ryoichi Suzuki, Kazuo Maeda,
We have developed a silicon oxi-carbide and nitride (SiOCNH) barrier film to protect against copper (Cu) thermal diffusion by plasma-enhanced chemical vapor deposition (PECVD) using hexamethyldisiloxane, nitrous oxide ( N 2 O ) , and ammonia ( NH 3 ) gases. We tried to enhance the Cu barrier property and etching selectivity for low dielectric constant (low- k ) film by adding nitrogen (N) into the barrier silicon oxicarbide (SiOCH) film. The film protects against Cu thermal diffusion at 450°C for 4 h in N 2 . The k ...
Tópico(s): Muon and positron interactions and applications
2003 - Institute of Physics | Journal of The Electrochemical Society
Ryoichi Inaba, Manabu Maeda, Setsuya Fujita, Naoko KASHIKI, Yoko Komura, C. Nagata, HIDHYO YOSHIDA, Seyed Mohammad MIRBOD, Hirotoshi Iwata, Yukiko SHIKANO, Yoshirô Ichiki, Shunji Mori,
In order to evaluate the prevalence rates of Raynaud's phenomenon (RP) and specific clinical signs related to progressive systemic sclerosis (PSS) in the general population of Japan, inquiries were made concerning RP in the hands and dermatologic examinations were also conducted.One thousand and sixty-three subjects (332 men and 731 women) over 30 years of age who underwent inhabitants' health examinations in 1990 were considered for this study.The prevalence of RP was 3.0% in men and 3.4% in women. ...
Tópico(s): Skin Diseases and Diabetes
1993 - Wiley | International Journal of Dermatology
Koki Matsumoto, Hiroshi Maeda, Ryoichi Okamura,
... Oxford Academic PubMed Google Scholar Hiroshi MAEDA, Hiroshi MAEDA *Departments of Microbiology, Kumamoto University Medical SchoolHonjo, Kumamoto, Kumamoto 860 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ryoichi OKAMURA Ryoichi OKAMURA **Departments of Ophthalmology, Kumamoto University ...
Tópico(s): Protease and Inhibitor Mechanisms
1984 - Oxford University Press | The Journal of Biochemistry
Kazuaki Yamanaka, Yoichi Kakuta, Shuji Miyagawa, Shigeaki Nakazawa, Taigo Kato, Toyofumi Abe, Ryoichi Imamura, Masayoshi Okumi, Akira Maeda, Hiroomi Okuyama, Masashi Mizuno, Norio Nonomura,
Background The association of complement with the progression of acute T cell mediated rejection (ATCMR) is not well understood. We investigated the production of complement components and the expression of complement regulatory proteins (Cregs) in acute T-cell mediated rejection using rat and human renal allografts. Methods We prepared rat allograft and syngeneic graft models of renal transplantation. The expression of Complement components and Cregs was assessed in the rat grafts using quantitative ...
Tópico(s): Adenosine and Purinergic Signaling
2016 - Public Library of Science | PLoS ONE
Ryoichi Nakashima, Chisaki Watanabe, Eriko Maeda, T. Yoshikawa, Izuru Matsuda, Soichiro Miki, Kazuhiko Yokosawa,
Tópico(s): Radiology practices and education
2014 - Springer Science+Business Media | Psychological Research
Ryoichi Nakashima, Kazufumi Kobayashi, Eriko Maeda, T. Yoshikawa, Kazuhiko Yokosawa,
The aims of this study are (a) to determine the effect of training on the multiple-target lesion search performance; and (b) to examine the effect of target prevalence on the performance of radiologists and novices. We conducted four sessions of 500 trials in a lesion search on a medical image task in which participants searched for three different target lesions. Participants were ten radiologists and novices. In each session, the prevalence of the different target lesions varied from low (2 %) to high ( ...
Tópico(s): Clinical Reasoning and Diagnostic Skills
2013 - Frontiers Media | Frontiers in Psychology
Soichiro Iimori, Yumi Noda, Tomokazu Okado, Shotaro Naito, Takayuki Toda, Yoshiko Chida, Michio Kuwahara, Ryoichi Ando, Yasuhide Nishio, Yoshitaka Maeda, Hiroyuki Tanaka, Teiichi Tamura, Shigeaki Kimoto, Eiichiro Kanda, Seiji Inoshita, Momono Yoshikawa, Rie Okutsu, Masato Tajima, Takashi Kusaura, Katsuki Kobayashi, Tatemitsu Rai, Shinichi Uchida, Sei Sasaki,
About 39,000 patients were newly prescribed renal replacement therapy in Japan in 2011, resulting in a total of more than 300,000 patients being treated with dialysis. This high prevalence of treated end stage kidney disease (ESKD) patients is an emergent problem that requires immediate attention. We launched a prospective cohort study to evaluate population specific characteristics of the progression of chronic kidney disease (CKD). In this report, we describe the baseline characteristics and risk ...
Tópico(s): Renal and Vascular Pathologies
2013 - BioMed Central | BMC Nephrology
Hirofumi Kamachi, Shigenori Homma, Hideki Kawamura, Tadashi Yoshida, Yousuke Ohno, Nobuki Ichikawa, Ryoichi Yokota, Tohru Funakoshi, Yoshiaki Maeda, Norihiko Takahashi, Toraji Amano, Akinobu Taketomi,
Abstract Background The role of antithrombotic chemoprophylaxis in prevention of venous thromboembolism (VTE) in laparoscopic surgery for gastric and colorectal malignancies is unknown. This study compared the addition of enoxaparin following intermittent pneumatic compression (IPC) with IPC alone in patients undergoing laparoscopic surgery for gastrointestinal malignancy. Methods In this multicentre RCT, eligible patients were older than 40 years and had a WHO performance status of 0 or 1. Exclusion ...
Tópico(s): Central Venous Catheters and Hemodialysis
2020 - Wiley | BJS Open
Nobuki Ichikawa, Shigenori Homma, Tohru Funakoshi, Takahiro Ohshima, Kunihiro HIROSE, K Yamada, Hiroki Nakamoto, K Kazui, Ryoichi Yokota, Toshio Honma, Yoshiaki Maeda, Tadashi Yoshida, Takahisa Ishikawa, Hiroaki Iijima, Takeshi Aiyama, Akinobu Taketomi,
Abstract Background The Endoscopic Surgical Skill Qualification System (ESSQS) was introduced in Japan to improve the quality of laparoscopic surgery. This cohort study investigated the short- and long-term postoperative outcomes of colorectal cancer laparoscopic procedures performed by or with qualified surgeons compared with outcomes for unqualified surgeons. Methods All laparoscopic colorectal resections performed from 2010 to 2013 in 11 Japanese hospitals were reviewed retrospectively. The procedures ...
Tópico(s): Surgical Simulation and Training
2020 - Wiley | BJS Open
Satoshi Ueno, Ryoichi Kuwano, Ryōsuke Shimizu, Ryohei Maeda,
o -( N -Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o -( N -alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.
Tópico(s): Asymmetric Synthesis and Catalysis
2012 - Thieme Medical Publishers (Germany) | Synlett
Ryuji Kamata, Koki Matsumoto, Ryoichi Okamura, Tetsuro Yamamoto, Hiroshi Maeda,
A possible cause and the difference in clinical severity of serratial keratitis were investigated. Two strains of Serratia marcescens were isolated: one from a patient with severe liquefactive keratitis, who had diabetes mellitus, and one from a patient with mild superficial keratitis, but who had no underlying disease. When the same numbers of bacteria were injected separately into corneas of the same rabbits or guinea pigs, the strain from the first patient elicited severe corneal destruction, ...
Tópico(s): Connexins and lens biology
1985 - Elsevier BV | Ophthalmology