Nobuhiro Fuke, Atsushi Fukui, Yasuo Chiba, Ryoichi Komiya, Ryosuke Yamanaka, Liyuan Han,
A new structure for dye-sensitized solar cells (DSCs) was proposed in which the transparent conducting oxide (TCO) is omitted and the cathode is located on the opposite side of the titanium dioxide (TiO2) film surface to the side of light irradiation. DSCs with this structure are called back contact DSCs (BCDSCs). The structure and fabrication of the cathode of BCDSCs was investigated in comparison with silicon solar cells. BCDSCs with conversion efficiency of 7.1% were achieved by vacuum deposition ...
Tópico(s): Transition Metal Oxide Nanomaterials
2007 - Institute of Physics | Japanese Journal of Applied Physics
Shinsuke Imai, Kohtaro Fujioka, Kazuo Furihata, Ryosuke Fudo, Shigeru Yamanaka, Haruo Seto,
In the course of our screening program for mammalian cell growth stimulating substances1'2), a gliding bacterium, Cytophaga johnsonae AJ No. 12589, isolated from Kanagawa Prefecture, Japan, was found to produce a substance stimulating the growth of NIH 3T3 mouse fibroblast cells in the presence of only 1% of fetal calf serum (FCS).Without addition of this substance, the cells did not show any growth under the same conditions.In this communication, we report isolation, characterization, and structural ...
Tópico(s): Bioactive Compounds and Antitumor Agents
1993 - Springer Nature | The Journal of Antibiotics
Bangi A. Kundim, Yu Itou, Youji Sakagami, Ryosuke Fudou, Shigeru Yamanaka, Makoto Ojika,
Three new unstable metabolites, (6E,10Z)-2′-O-methylmyxalamide D (1), 2′-O-methylmyxalamide D (2) and (6E)-2′-O-methylmyxalamide D (3) were isolated from the myxobacterium Cystobacter fuscus. The planar structures were elucidated by spectroscopic analyses to be geometrical isomers of a polyene amide related to a myxobacterial metabolite, myxalamide D (4). Their absolute stereochemistry was determined by synthesis of degradation products. Antifungal activities of 1–3 as well as their acetates were evaluated ...
Tópico(s): Alkaloids: synthesis and pharmacology
2004 - Elsevier BV | Tetrahedron
Keiko Imamura, Yuishin Izumi, Akira Watanabe, Kayoko Tsukita, Knut Woltjen, Takuya Yamamoto, Akitsu Hotta, Takayuki Kondo, Shiho Kitaoka, Akira Ohta, Akito Tanaka, Dai Watanabe, Mitsuya Morita, Hiroshi Takuma, Akira Tamaoka, Tilo Kunath, Selina Wray, Hirokazu Furuya, Takumi Era, Kouki Makioka, Koichi Okamoto, Takao Fujisawa, Hideki Nishitoh, Kengo Homma, Hidenori Ichijo, Jean‐Pierre Julien, Nanako Obata, Masato Hosokawa, Haruhiko Akiyama, Satoshi Kaneko, Takashi Ayaki, Hidefumi Ito, Ryuji Kaji, Ryōsuke Takahashi, Shinya Yamanaka, Haruhisa Inoue,
Analysis of ALS patient iPSC-derived motor neurons indicates that Src/c-Abl inhibitors may have potential for treating ALS.
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2017 - American Association for the Advancement of Science | Science Translational Medicine
Yoshimi Watanabe, Ryosuke Yamazaki, Kunika Yamanaka, Hisashi Sato,
In this study, an L12-modified Al2.5Cu0.5Ti intermetallic compound was chosen as a heterogeneous nucleation site to develop grain refiners for cast Al with a high volume fraction of heterogeneous nucleation site particles. Al2.5Cu0.5Ti intermetallic compound particles with an L12 structure were prepared by crushing the bulk material obtained by arc melting or directly by gas atomization. Al–10 vol% Al2.5Cu0.5Ti, Al–20 vol% Al2.5Cu0.5Ti, Al–30 vol% Al2.5Cu0.5Ti and Al–40 vol% Al2.5Cu0.5Ti refiners ...
Tópico(s): Bauxite Residue and Utilization
2017 - Elsevier BV | Journal of Materials Processing Technology
Shoji Iguchi, Masashi Kataoka, Ryôsuke Hoshino, Ichiro Yamanaka,
Direct electro-epoxidation of C 3 H 6 with water was achieved using a solid polymer electrolyte (SPE) electrolysis cell.
Tópico(s): Advanced battery technologies research
2021 - Royal Society of Chemistry | Catalysis Science & Technology
Y. Ikejiri, Makoto Uemura, Mahito Sasada, Ryosuke Ito, M. Yamanaka, Kiyoshi Sakimoto, Akira Arai, Y. Fukazawa, Takashi Ohsugi, Koji S. Kawabata, M. Yoshida, Shuji Sato, Masaru Kino,
We report on the correlation between the flux, color and polarization variations on time scales of days--months in blazars, and discuss their universal aspects. We performed monitoring of 42 blazars in the optical and near-infrared bands from 2008 to 2010 using TRISPEC attached to the "Kanata" 1.5-m telescope. We found that 28 blazars exhibited "bluer-when-brighter" trends in their whole or a part of time-series data sets. This corresponds to 88% of objects that were observed for >10 days. Thus, our ...
Tópico(s): Dark Matter and Cosmic Phenomena
2011 - Oxford University Press | Publications of the Astronomical Society of Japan
Hiroyuki Akita, Takamitsu Sasaki, Keisuke Kato, Yoshihiro Suzuki, Keiko Kondo, Youji Sakagami, Makoto Ojika, Ryosuke Fudou, Shigeru Yamanaka,
Tópico(s): Bioactive Compounds and Antitumor Agents
2004 - Elsevier BV | Tetrahedron
Naoko Tsuyoshi, Ryosuke Fudou, Shigeru Yamanaka, Michio KOZAKI, Namrata Tamang, Saroj Thapa, Jyoti Prakash Tamang,
Marcha or murcha is a traditional amylolytic starter used to produce sweet-sour alcoholic drinks, commonly called jaanr in the Himalayan regions of India, Nepal, Bhutan, and Tibet (China). The aim of this study was to examine the microflora of marcha collected from Sikkim in India, focusing on yeast flora and their roles. Twenty yeast strains were isolated from six samples of marcha and identified by genetic and phenotypic methods. They were first classified into four groups (Group I, II, III, and ...
Tópico(s): Probiotics and Fermented Foods
2004 - Elsevier BV | International Journal of Food Microbiology
Akinori Kuzuya, Ryosuke Watanabe, Yusei Yamanaka, Takuya Tamaki, Masafumi Kaino, Yuichi Ohya,
Single-molecule pH sensors have been developed by utilizing molecular imaging of pH-responsive shape transition of nanomechanical DNA origami devices with atomic force microscopy (AFM). Short DNA fragments that can form i-motifs were introduced to nanomechanical DNA origami devices with pliers-like shape (DNA Origami Pliers), which consist of two levers of 170-nm long and 20-nm wide connected at a Holliday-junction fulcrum. DNA Origami Pliers can be observed as in three distinct forms; cross, antiparallel ...
Tópico(s): DNA and Nucleic Acid Chemistry
2014 - Multidisciplinary Digital Publishing Institute | Sensors
Takashi Iizuka, Yasuko Jojima, Ryosuke Fudou, Shigeru Yamanaka,
In an attempt to isolate indigenous marine myxobacteria from coastal samples, we obtained two swarm forming bacteria. Both isolates formed cell aggregates which, at least in one isolate, developed to fruiting body-like structures consisting of a mass of myxospore-like cells. The optimum NaCl concentrations for their growth were between 2 and 3%, comparable to the NaCl concentration of seawater. This growth characteristic strongly suggests that the two isolates are specific marine bacteria. The 16S ...
Tópico(s): Microbial Community Ecology and Physiology
1998 - Oxford University Press | FEMS Microbiology Letters
Yoshihiro Suzuki, Makoto Ojika, Youji Sakagami, Ryosuke Fudou, Shigeru Yamanaka,
Bithiazole-type antifungal products, cystothiazoles C-F (3–6), have been isolated from a culture broth of the myxobacterium Cystobacter fuscus as minor components. These are structurally related to cystothiazole A (1), which was isolated as a cytotoxic antibiotic from the same microorganism in our previous work. The structures of these compounds were elucidated by spectroscopic analyses. These new compounds inhibit the phytopathogenic fungus, Phytophthora capsici, but are less active than 1.
Tópico(s): Microbial Natural Products and Biosynthesis
1998 - Elsevier BV | Tetrahedron
Takaya Nagata, Atsuko Tamaki, Kensuke Kiyokawa, Ryosuke Tsutsumi, Masahiro Yamanaka, Satoshi Minakata,
Chiral β-ketonitriles bearing a stereogenic carbon center at the α-position are an important class of compounds, many of which serve as useful synthetic intermediates for the preparation of chiral 1,3-aminoalcohols, β-hydroxy nitriles, and related derivatives. Although the enantioselective electrophilic cyanation of enolate equivalents is one of the most promising approaches for the synthesis of chiral β-ketonitriles, the available methods are largely limited to reactions of 1,3-dicarbonyl compounds. ...
Tópico(s): Asymmetric Synthesis and Catalysis
2018 - Wiley | Chemistry - A European Journal
Ignacio Ibáñez, Mio Kaneko, Yuto Kamei, Ryosuke Tsutsumi, Masahiro Yamanaka, Takahiko Akiyama,
An efficient enantioselective Friedel–Crafts alkylation reaction of indoles with α-CF3-substituted β-nitrostyrenes is disclosed. The key to success is the use of a chiral calcium BINOL bis(phosphate) complex as a Lewis acid catalyst. The reaction gives access to a wide variety of optically active indoles bearing trifluoromethylated all-carbon quaternary stereocenter (up to 20 examples) in high yields (up to 99%) with excellent enantioselectivities (up to 98%) under mild reaction conditions. Nonactivated ...
Tópico(s): Chemical Synthesis and Reactions
2019 - American Chemical Society | ACS Catalysis
Risa Tamura, Eriko Kitamura, Ryosuke Tsutsumi, Masahiro Yamanaka, Takahiko Akiyama, Keiji Mori,
Developed herein is a diastereoselective synthesis of CF3-substituted spiroisochromans via C(sp3)–H bond functionalization involving sequential transformations ([1,5]-hydride shift/cyclization/elimination of MeOH/intramolecular Friedel–Crafts reaction).
Tópico(s): Synthesis and Catalytic Reactions
2019 - American Chemical Society | Organic Letters
Takayoshi Arai, Kodai Horigane, Takumi Suzuki, Ryosuke Itoh, Masahiro Yamanaka,
Catalytic asymmetric iodoesterification of simple alkenes was achieved using a dinuclear zinc-3,3'-(R,S,S)-bis(aminoimino)binaphthoxide (di-Zn) complex. For iodoesterification using p-methoxybenzoic acid, the N-iodonaphthalenimide (NIN)-I2 system was effective for producing iodoesters in a highly enantioselective manner. The synthetic utility of chiral iodo-p-methoxybenzoates was also demonstrated. The quartet of metal ionic bond, hydrogen bond, halogen bond, and π-π stacking is harmonized on the ...
Tópico(s): Chemical Synthesis and Reactions
2020 - Wiley | Angewandte Chemie International Edition
Yuka Morikawa, Seiji Takayama, Ryosuke Fudo, Shigeru Yamanaka, Kenji Mori, Akira Isogai,
Stigmatella aurantiaca, a species of myxobacteria, produces a novel extracellular signaling molecule, 8-hydroxy-2,5,8-trimethyl-4-nonanone, which promotes its developmental cycle. To determine the absolute configuration of this pheromone, which contains one asymmetric carbon, we prepared the R- and S-enantiomers by stereoselective synthesis. The synthesized R- and S-enantiomers each showed nearly the same fruiting body-inducing activities as the natural pheromone. Gas chromatography-mass spectrometry ( ...
Tópico(s): Marine Sponges and Natural Products
1998 - Oxford University Press | FEMS Microbiology Letters
Shigeru Yamanaka, Ryosuke Fudo, Akihiko Kawaguchi, Kazuo Komagata,
The cellular hydroxy fatty acid composition of myxobacteria was investigated.Strains tested included 7 strains of Myxococcus species and one strain of Archangiunr, together with other gliding bacteria, 2 strains of Cytophaga species, as reference bacteria.Myxobacteria commonly had 2hydroxy and 3-hydroxy fatty acids as the hydroxy fatty acid components.The hydroxy fatty acid profile of myxobacteria was characterized as follows: 2-hydroxy-l5-methylhexadecanoic acid (2-OH iso C17:0) is the major hydroxy ...
Tópico(s): Myxozoan Parasites in Aquatic Species
1988 - Microbiology Research Foundation | The Journal of General and Applied Microbiology
Yoon Jeong Kim, Kazuo Furihata, Shigeru Yamanaka, Ryosuke Fudo, Haruo Seto,
Tópico(s): Pharmacogenetics and Drug Metabolism
1991 - Springer Nature | The Journal of Antibiotics
Takao Yamanaka, Ryosuke Matsumoto, Takamichi Nakamoto,
An odor recorder has the capability of not only recording odors electronically but also reproducing it anytime and anywhere. In this paper, we developed a new type of odor recorder, composed of the odor blenders that generate the mixture of components at any composition using solenoid valves controlled by the delta–sigma modulation method. We optimized the parameters of modulation and the characteristic of the low pass filter by simulation. Moreover, the recipes of apple flavor, jasmine scent, and ...
Tópico(s): Olfactory and Sensory Function Studies
2002 - Elsevier BV | Sensors and Actuators B Chemical
Takao Yamanaka, Ryosuke Matsumoto, Takamichi Nakamoto,
The odor recorder has been developed using the odor sensing system based on the active sensing method to electronically record odors and reproduce them anytime and anywhere. The recorder developed in this paper has capability of recording the target odor, the mixture of five odor components, using the odor sensor array composed of quartz crystal microbalance sensors. The difference between the sensor response patterns of the recipe and target odors was minimized so that the recipe of the five components ...
Tópico(s): Insect Pheromone Research and Control
2003 - Elsevier BV | Sensors and Actuators B Chemical
Toshio Yamanaka, Ryosuke Matsumoto, Takamichi Nakamoto,
A new method for the odor recorder, electronically recording the recipe of odors or scents made up of many components, was proposed. Although apple flavors have been recorded with a mixture of five components using the odor recorder in previous work, the number of odor components should be increased to expand the applicable range of odors. Since the collinearity problem of the odor sensor array became apparent with the increase of components, a new method based on variable transformation using singular ...
Tópico(s): Olfactory and Sensory Function Studies
2003 - IEEE Sensors Council | IEEE Sensors Journal
Tsutomu Yamanaka, Ryōsuke Shimizu,
We measured the stable isotopic composition of hydrogen (δD) within atmospheric water vapor collected simultaneously at six sites in the vicinity of a lake (Lake Kasumigaura, Eastern Japan) to determine its spatial distribution characteristics and thereby diagnose sources and mixing of atmospheric moisture. The measured spatial distribution of δD showed no relation to distance from the lake, although it showed a correlation with the distribution of the water–vapor mixing ratio Q. For two of the three ...
Tópico(s): Radioactive contamination and transfer
2007 - Elsevier BV | Geochimica et Cosmochimica Acta
Hirofumi Yamashita, Jun Kawamata, Katsuya Okawa, Rie Kanki, Tomoki Nakamizo, Takumi Hatayama, Koji Yamanaka, Ryōsuke Takahashi, Shun Shimohama,
A dominant mutation in the gene for copper-zinc superoxide dismutase (SOD1) is the most frequent cause of the inherited form of amyotrophic lateral sclerosis. Mutant SOD1 provokes progressive degeneration of motor neurons by an unidentified acquired toxicity. Exploiting both affinity purification and mass spectrometry, we identified a novel interaction between heat-shock protein 105 (Hsp105) and mutant SOD1. We detected this interaction both in spinal cord extracts of mutant SOD1(G93A) transgenic ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2007 - Wiley | Journal of Neurochemistry
Takashi Iizuka, Mitsunori Tokura, Yasuko Jojima, Akira Hiraishi, Shigeru Yamanaka, Ryosuke Fudou,
During the search for thermophilic myxobacteria in geothermal environments, four myxobacteria-like cultures that grew at temperatures of up to 50°C and optimally at 45-49°C were enriched from various hot springs in Japan. Three of the cultures were derived from freshwater hot springs and one from a coastal saline spring. Although all lacked fruiting structures, they were bacteriolytic and formed diffusive shallow crater-like colonies. Even after repeated enrichment procedures using Escherichia coli- ...
Tópico(s): Genomics and Phylogenetic Studies
2006 - Japanese Society Of Microbial Ecology | Microbes and Environments
Takashi Iizuka, Yasuko Jojima, Atsushi Hayakawa, Takayoshi Fujii, Shigeru Yamanaka, Ryosuke Fudou,
A myxobacterial strain, designated SYR-2(T), was obtained from a mud sample from an estuarine marsh alongside the Yoshino River, Shikoku, Japan. It had rod-shaped vegetative cells and formed bacteriolytic enlarging colonies or so-called 'swarms' in the agar media. Fruiting-body-like globular to polyhedral cell aggregates and myxospore-like spherical to ellipsoidal cells within them were observed. Those features coincided with the general characteristics of myxobacteria. The strain was mesophilic ...
Tópico(s): Genomics and Phylogenetic Studies
2012 - Microbiology Society | INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
Yasuko Jojima, Yasuhiro Mihara, Sonoko Suzuki, Kenzo Yokozeki, Shigeru Yamanaka, Ryosuke Fudou,
Three Gram-negative, aerobic, rod-shaped bacterial strains were isolated, from the pollen of Japanese flowers, as producers of xylitol; these strains were subjected to a polyphasic taxonomic study. Phylogenetic analyses of the 16S rRNA gene sequences demonstrated that these three isolates formed a new cluster within a group of acetic acid bacteria in the alpha-Proteobacteria. The characteristics of the three isolates were as follows: (i) their predominant quinone was Q-10; (ii) their cellular fatty ...
Tópico(s): Enzyme Production and Characterization
2004 - Microbiology Society | INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
Atsushi Yamanaka, Ryosuke Suzuki, Eiji Konishi,
Dengue fever and dengue hemorrhagic fever are endemic throughout tropical and subtropical countries. Four serotypes of dengue viruses (DENV-1 to DENV-4), each with several genotypes including various subclades, are co-distributed in most endemic areas. Infection–neutralizing and -enhancing antibodies are believed to play protective and pathogenic roles, respectively. Measurement of these functional antibodies against a variety of viral strains is thus important for evaluating coverage and safety of ...
Tópico(s): Viral Infections and Outbreaks Research
2014 - Elsevier BV | Vaccine
Terufumi Kato, Takashi Seto, Makoto Nishio, Kōichi Goto, Shinji Atagi, Yukio Hosomi, Noboru Yamamoto, Toyoaki Hida, Makoto Maemondo, Kazuhiko Nakagawa, Seisuke Nagase, Isamu Okamoto, Takeharu Yamanaka, Ryosuke Harada, Masahiro Fukuoka, Nobuyuki Yamamoto,
8005 Background: Despite the development of EGFR tyrosine kinase inhibitors, median progression-free survival (PFS) is only about 13 months in patients with EGFR mutation–positive NSCLC. However, results from the BeTa Lung study for a subgroup of patients with EGFR mutation suggest that EB may prolong PFS in these patients. Methods: Open-label randomized trial. Patients with stage 3b/4 or recurrent non-squamous EGFR mutation–positive NSCLC, ECOG performance status 0/1, and no previous chemotherapy ...
Tópico(s): Colorectal Cancer Treatments and Studies
2014 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Shi‐Wei Chu, Hsueh-Yu Wu, Yen-Ta Huang, Tung-Yu Su, Hsuan Lee, Yasuo Yonemaru, Masahito Yamanaka, Ryosuke Oketani, Satoshi Kawata, Satoru Shoji, Katsumasa Fujita,
Nonlinear optical interaction is crucial to all-optical signal processing. In metallic nanostructures, both linear and nonlinear optical interactions can be greatly enhanced by surface plasmon resonance (SPR). In the last few decades, saturation and reverse saturation of absorption in plasmonic materials have been unraveled. It is known that scattering is one of the fundamental light–matter interactions and is particularly strong in metallic nanoparticles due to SPR. However, previous methods measure ...
Tópico(s): Nonlinear Optical Materials Studies
2013 - American Chemical Society | ACS Photonics