W. Wardzyński, W. Giriat, H. Szymczak, Ryszard Kowalczyk,
Abstract The effect of uniaxial stress on the exciton reflection spectrum at 77 °K of ZnTe was studied by the wavelength modulation technique. The observed splitting is explained taking into account the exchange interaction between the spins of the electron and the hole composing the excition. From comparison of the experiment and the appropriate theory it is concluded that in ZnTe at 77 °K the second‐order term of exchange interaction being linear in strain and describing the variation of exchange ...
Tópico(s): Semiconductor Quantum Structures and Devices
1972 - Wiley | physica status solidi (b)
Ireneusz Sowa, Magdalena Wójciak, Maciej Strzemski, Sławomir Dresler, Wojciech Szwerc, Tomasz Blicharski, Grażyna Szymczak, Ryszard Kocjan,
Soy (Glycine max (L.) Merr.) is an annual plant cultivated worldwide mostly for food. Moreover, due to its pharmacological properties it is widely used in pharmacy for alleviating the symptoms of osteoporosis. The aim of the present study was to investigate the biofortification of soy treated with various concentrations of strontium. Soy was found to have a strong capacity to absorb Sr(2+) (bioconcentration factor higher than 1). A positive linear correlation (R(2) > 0.98) between the amount of strontium ...
Tópico(s): Plant Genetic and Mutation Studies
2014 - American Chemical Society | Journal of Agricultural and Food Chemistry
Magdalena Wójciak, Ireneusz Sowa, Kamila Pucek, Grażyna Szymczak, Ryszard Kocjan, Piotr Luchowski,
Context: Viscum album L. (Loranthaceae) is a semi-parasitic plant used in pharmacy and medicine mostly for its hypotensive and anticancer activity. The effects may be related to the presence of triterpenic acids, such as betulinic (BA) and oleanolic (OA) acids.Objectives: In our investigations the content of triterpenic acids in V. album from different host trees depending on the season of harvest was determined.Material and methods: V. album herb was dried and extracted with ethyl acetate using ultrasound ...
Tópico(s): Plant Parasitism and Resistance
2016 - Taylor & Francis | Pharmaceutical Biology
Paweł Kowalczyk, Arleta Madej, Daniel Paprocki, Mateusz Szymczak, Ryszard Ostaszewski,
Coumarins are natural compounds that were detected in 80 species of plants. They have numerous applications including the medical, food, tobacco, perfumery, and spirit industries. They show anti-swelling and diastolic effects. However, excess consumption of coumarins may adversely affect our health, because they are easily absorbed from the intestines into the lymph and blood, causing cirrhosis of the liver. Peptidomimetics are molecules whose structure and function are similar to those of peptides. ...
Tópico(s): Biochemical and Structural Characterization
2020 - Multidisciplinary Digital Publishing Institute | Materials
Paweł Kowalczyk, Arleta Madej, Mateusz Szymczak, Ryszard Ostaszewski,
A preliminary study of α-amidoamids as new potential antimicrobial drugs was performed. Special emphasis was placed on selection of structure of α-amidoamids with the highest biological activity against different types of Gram-stained bacteria by lipopolysaccharide (LPS). Herein, Escherichia coli model strains K12 (without LPS in its structure) and R1-R4 (with different length LPS in its structure) were used. The presented work showed that the antibacterial activity of α-amidoamids depends on their ...
Tópico(s): Synthesis and biological activity
2020 - Multidisciplinary Digital Publishing Institute | Materials
Dominik Koszelewski, Paweł Kowalczyk, Paweł Śmigielski, Jan Samsonowicz‐Górski, Karol Kramkowski, Aleksandra Wypych, Mateusz Szymczak, Ryszard Ostaszewski,
We reported a new method dealing with the synthesis of novel pharmacologically relevant α-aminophosphonate derivatives via a lipase-catalyzed Kabachnik−Fields reaction with yields of up to 93%. The advantages of this protocol are excellent yields, mild reaction conditions, low costs, and sustainability. The developed protocol is applicable to a range of H-phosphites and organic amines, providing a wide substrate scope. A new class of α-aminophosphonate analogues possessing P-chiral centers was also ...
Tópico(s): HIV/AIDS drug development and treatment
2022 - Multidisciplinary Digital Publishing Institute | Materials
Magdalena Wójciak, Ireneusz Sowa, Tomasz Blicharski, Maciej Strzemski, Sławomir Dresler, Grażyna Szymczak, Artur Wnorowski, Ryszard Kocjan, Ryszard Świeboda,
The amount of secondary metabolites in plants can be enhanced or reduced by various external factors. In this study, the effect of strontium ions on the production of phytoestrogens in soybeans was investigated. The plants were treated with Hoagland’s solution, modified with Sr2+ with concentrations ranging from 0.5 to 3.0 mM, and were grown for 14 days in hydroponic cultivation. After harvest, soybean plants were separated into roots and shoots, dried, and pulverized. The plant material was extracted ...
Tópico(s): Plant Growth and Agriculture Techniques
2016 - Multidisciplinary Digital Publishing Institute | Molecules
Paweł Kowalczyk, Damian Trzepizur, Mateusz Szymczak, G. Skiba, Karol Kramkowski, Ryszard Ostaszewski,
An initial study of 1,2-diarylethanols derivatives as new potential antibacterial drugs candidates was conducted. Particular emphasis was placed on the selection of the structure of 1,2-diarylethanols with the highest biological activity of lipopolysaccharides (LPS) in the model strains of Escherichia coli K12 (without LPS in its structure) and R2–R4 (with different lengths of LPS in its structure). In the presented studies, based on the conducted minimum inhibitory concentration (MIC) and MBC tests, ...
Tópico(s): Chemical and Physical Properties in Aqueous Solutions
2021 - Multidisciplinary Digital Publishing Institute | Materials
Jan Samsonowicz‐Górski, Dominik Koszelewski, Paweł Kowalczyk, Paweł Śmigielski, Anastasiia Hrunyk, Karol Kramkowski, Aleksandra Wypych, Mateusz Szymczak, Rafał Lizut, Ryszard Ostaszewski,
An enzymatic route for phosphorous-carbon bond formation was developed by discovering new promiscuous activity of lipase. We reported a new metal-free biocatalytic method for the synthesis of pharmacologically relevant β-phosphonomalononitriles via a lipase-catalyzed one-pot Knoevenagel-phospha-Michael reaction. We carefully analyzed the best conditions for the given reaction: the type of enzyme, temperature, and type of solvent. A series of target compounds was synthesized, with yields ranging ...
Tópico(s): Click Chemistry and Applications
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Ireneusz Sowa, Magdalena Wójciak, Kamila Rokicka, Ryszard Kocjan, Grażyna Szymczak,
The new sorbent based on silica gel coated with a film of polyaniline (Si-PANI) was obtained in a process of in situ polymerization directly on carrier particles and its potential application for pretreatment of plant material samples with the use of solid phase extraction (SPE) was investigated. Parameters such as cartridge conditioning, the volume and concentration of the sample, the type and volume of the elution solvent were optimized and compared with parameters obtained for RP-18 and aminopropyl ...
Tópico(s): Analytical Chemistry and Sensors
2014 - Elsevier BV | Talanta
Kinga Skoracka, Szymon Hryhorowicz, Anna Maria Rychter, Alicja Ewa Ratajczak, Aleksandra Szymczak‐Tomczak, Agnieszka Zawada, Ryszard Słomski, Agnieszka Dobrowolska, Iwona Krela‐Kaźmierczak,
The prevalence of celiac disease increased in recent years. In addition to the genetic and immunological factors, it appears that environmental determinants are also involved in the pathophysiology of celiac disease. Gastrointestinal infections impact the development of celiac disease. Current research does not directly confirm the protective effect of natural childbirth and breastfeeding on celiac disease. However, it seems that in genetically predisposed children, the amount of gluten introduced ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2023 - Frontiers Media | Frontiers in Nutrition
Z. Tomkowicz, Peter Fleischhauer, W. Haase, M. Baran, R. Szymcżak, A. Zaleski, Ryszard Jabłoński,
Comparative studies of linear Cu3BuBz·2EtOH, Cu3BuNaEs·2MeOH and nonlinear Cu3EtBz·H2O and Cu3BuBz·H2O trimeric Cu(II) complexes are presented. The results have been obtained by means of SQUID magnetometry, AC susceptibility and ESR spectroscopy methods. Linear trimers are relatively well separated in the crystal lattice and their paramagnetic behavior is well described based on a total spin Hamiltonian. Cu3BuNaEs·2MeOH shows a weak temperature dependence of the resonance field on ESR spectra with ...
Tópico(s): Metal complexes synthesis and properties
1997 - Elsevier BV | Journal of Magnetism and Magnetic Materials
Jan Samsonowicz‐Górski, Paweł Kowalczyk, Dominik Koszelewski, Anna Brodzka, Mateusz Szymczak, Karol Kramkowski, Ryszard Ostaszewski,
The biological research on newly synthesized amidoximes, Boc-protected amidoximes and Boc-derived amidines, obtained by a reduction of the parent amidoximes is reported, herein. Due to the presence of a free amino group in both amidines and amidoximes, these compounds can undergo various chemical reactions such as N-alkylation and N-acylation. One such reaction is Boc-protection, often used in organic synthesis to protect the amino and imino groups. Until now, Boc-protected amidoximes have not been ...
Tópico(s): Antimicrobial agents and applications
2021 - Multidisciplinary Digital Publishing Institute | Materials
Dorota Skrzypczak, Marzena Skrzypczak-Zielińska, Alicja Ewa Ratajczak, Aleksandra Szymczak‐Tomczak, Piotr Eder, Ryszard Słomski, Agnieszka Dobrowolska, Iwona Krela‐Kaźmierczak,
Sarcopenia, which is a decrease in muscle strength and quality of muscle tissue, is a common disorder among patients suffering from inflammatory bowel disease. This particular group of patients often presents with malnutrition and shows low physical activity, which increases the risk of sarcopenia. Another important factor in the development of sarcopenia is an imbalanced ratio of myostatin and follistatin, which may stem from inflammation as well as genetic factors. Currently, research in this ...
Tópico(s): Clinical Nutrition and Gastroenterology
2021 - Multidisciplinary Digital Publishing Institute | Biomedicines
Parul Sahrawat, Paweł Kowalczyk, Dominik Koszelewski, Mateusz Szymczak, Karol Kramkowski, Aleksandra Wypych, Ryszard Ostaszewski,
An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good yields. Further, using the developed cyclisation reaction, the obtained peptidomimetics were transformed into the cyclic analogues (diketopiperazines, DKPs). The goal of the performed studies was to revised and compare whether the structure of the obtained structurally flexible ...
Tópico(s): Peptidase Inhibition and Analysis
2022 - Multidisciplinary Digital Publishing Institute | Molecules
Paweł Kowalczyk, Mateusz Szymczak, Magdalena Maciejewska, Łukasz Laskowski, Magdalena Laskowska, Ryszard Ostaszewski, G. Skiba, Ida Franiak‐Pietryga,
Silver and its nanoparticles (AgNPs) have different faces, providing different applications. In recent years, the number of positive nanosilver applications has increased substantially. It has been proven that AgNPs inhibit the growth and survival of bacteria, including human and animal pathogens, as well as fungi, protozoa and arthropods. Silver nanoparticles are known from their antiviral and anti-cancer properties; however, they are also very popular in medical and pharmaceutical nanoengineering ...
Tópico(s): Graphene and Nanomaterials Applications
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Grażyna Szymczak, Magdalena Wójciak, Ireneusz Sowa, Karolina Zapała, Maciej Strzemski, Ryszard Kocjan,
Isoflavones are the main phenolic compounds of soy influencing its biological activity; however, their amount may differ significantly. In this work, the content of isoflavones in various soy taxa was determined using the high performance liquid chromatography with diode array detection (HPLC-DAD) and mass spectrometry (MS) technique. Moreover, the total phenolic content (TPC) and the antioxidant activity of the investigated soybean seeds were analysed using UV–vis spectrophotometric assays. Daidzin ( ...
Tópico(s): GABA and Rice Research
2016 - Elsevier BV | Journal of Food Composition and Analysis
Paweł Kowalczyk, Barbara Gawdzik, Damian Trzepizur, Mateusz Szymczak, G. Skiba, S. Raj, Karol Kramkowski, Rafał Lizut, Ryszard Ostaszewski,
Lactones are among the well-known organic substances with a specific taste and smell. They are characterized by antibacterial, antiviral, anti-inflammatory, and anti-cancer properties. In recent years, among this group of compounds, new biologically active substances have been searched by modifying the main (leading) structure with new analogs with stronger or different responses that may have a toxic effect on the cells of pathogenic bacteria and constitute an alternative to commonly used antibiotics. ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2021 - Multidisciplinary Digital Publishing Institute | Materials
Magdalena Wójciak, Ireneusz Sowa, Grażyna Szymczak, Karolina Zapała, Ryszard Kocjan, Tomasz Blicharski,
Tópico(s): Food composition and properties
2016 - Springer Science+Business Media | Chemical Papers
Paweł Kowalczyk, Monika Wilk, Parul Sahrawat, Mateusz Szymczak, Karol Kramkowski, S. Raj, G. Skiba, Dorota Sulejczak, Patrycja Kleczkowska, Ryszard Ostaszewski,
This work presents the successful synthesis of a library of novel peptidomimetics via Ugi multicomponent reaction. Most of these peptidomimetics contain differently substituted aminocoumarin; 7-amino-4-methylcoumarin and 7-amino-4-(trifluoromethyl) coumarin. Inspired by the biological properties of coumarin derivatives and peptidomimetics, we proposed the synthesis of coumarin incorporated peptidomimetics. We studied the potential of synthesized compounds as antimicrobial drugs on model E. coli ...
Tópico(s): Chemical Synthesis and Analysis
2021 - Multidisciplinary Digital Publishing Institute | Materials
Daniel Lipiński, Joanna Zeyland, Marlena Szalata, Andrzej Pławski, Małgorzata Jarmuż‐Szymczak, Jacek Jura, A. Korcz, Z. Smorąg, Marek Pieńkowski, Ryszard Słomski,
The advent of transgenic technology has provided methods for the production of pharmaceuticals by the isolation of these proteins from transgenic animals. The mammary gland has been focused on as a bioreactor, since milk is easily collected from lactating animals and protein production can be expressed at very high levels, including hormones and enzymes. We demonstrate here the expression pattern of recombinant human growth hormone (rhGH) in transgenic rabbits carrying hGH genomic sequences driven ...
Tópico(s): Infant Nutrition and Health
2012 - Springer Nature | Journal of Applied Genetics
G. Grelowska, Eugeniusz Kozaczka, Andrzej Nowicki, S. Kozaczka, Wojciech Szymczak, Ryszard Tymkiewicz,
Investigation and operation of devices based on nonlinear interaction of high-intensity waves have been carried out for several decades.However, it is still a new tool to study the properties of the water environment and especially the upper layers of the seabed.This paper describes the results of tests of the new device that is intended to be applied for sounding underwater areas.The device has been designed and built in collaboration with the Department of Ultrasound of the Institute of Fundamental ...
Tópico(s): Flow Measurement and Analysis
2013 - Polish Academy of Sciences | Acta Physica Polonica A
Iwona Krela‐Kaźmierczak, Marzena Skrzypczak-Zielińska, Marta Kaczmarek-Ryś, Michał Michalak, Aleksandra Szymczak‐Tomczak, Szymon Hryhorowicz, Marlena Szalata, Liliana Łykowska‐Szuber, Piotr Eder, Kamila Stawczyk‐Eder, Maciej Tomczak, Ryszard Słomski, Agnieszka Dobrowolska,
Decreased bone mass in patients with inflammatory bowel diseases (IBD) is a clinical problem with extremely severe consequences of osteoporotic fractures. Despite its increasing prevalence and the need for mandatory intervention and monitoring, it is often ignored in IBD patients' care. Determining the biomarkers of susceptibility to bone mineral density disorder in IBD patients appears to be indispensable. We aim to investigate the impact of estrogen receptor gene (ESR1) gene polymorphisms on bone ...
Tópico(s): Bone health and osteoporosis research
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Iwona Krela‐Kaźmierczak, Oliwia Zakerska‐Banaszak, Marzena Skrzypczak-Zielińska, Liliana Łykowska‐Szuber, Aleksandra Szymczak‐Tomczak, Agnieszka Zawada, Anna Maria Rychter, Alicja Ewa Ratajczak, Kinga Skoracka, Dorota Skrzypczak, Emilia Marcinkowska, Ryszard Słomski, Agnieszka Dobrowolska,
Despite the increasing knowledge with regard to IBD (inflammatory bowel disease), including ulcerative colitis (UC) and Crohn’s disease (CD), the etiology of these conditions is still not fully understood. Apart from immunological, environmental and nutritional factors, which have already been well documented, it is worthwhile to look at the possible impact of genetic factors, as well as the composition of the microbiota in patients suffering from IBD. New technologies in biochemistry allow to obtain ...
Tópico(s): Gastrointestinal motility and disorders
2022 - Multidisciplinary Digital Publishing Institute | Nutrients
M Panek, Marek Szymczak, Maria Stepaniuk, Wojciech Górecki, Aleksandra Gawłowska, Przemysław Wolak, Dariusz Zbyrad, Marek Rybkiewicz, Kamila Chrobak, Ryszard Noparlik, Jerzy Niedzielski, Przemysław Janik, Jan Krzysztof Nowak, Witold Miaśkiewicz, Andrzej Kamiński, W.O. Fischer, Bożenna Dembowska–Bagińska, Piotr Kaliciński,
Introduction The aim of the study was to examine management of pediatric appendiceal neuroendocrine tumors (ANETs) in Poland. Material and methods Records of 27 patients with ANET diagnosed incidentally after appendectomy in the last decade. Results Well-differentiated NET G1/G2 was diagnosed in 25 and well-differentiated neuroendocrine carcinoma G3 in 2 patients. Extended surgery was performed primarily in one instance and secondarily in 10 patients (right hemicolectomy in 9, ileocecal resection ...
Tópico(s): Ovarian cancer diagnosis and treatment
2021 - Termedia Publishing House | Archives of Medical Science
Anna Brodzka, Paweł Kowalczyk, Damian Trzepizur, Dominik Koszelewski, Karol Kramkowski, Mateusz Szymczak, Aleksandra Wypych, Rafał Lizut, Ryszard Ostaszewski,
The impact of substituent at phenyl ring of diethyl benzylphosphonate derivatives on cytotoxic activity was studied. The organophosphonates were obtained based on developed palladium-catalyzed α, β-homodiarylation of vinyl esters protocol. The new synthetic pathway toward 1,2-bis(4-((diethoxyphosphoryl)methyl)phenyl)ethyl acetate was proposed which significantly improves the overall yield of the final product (from 1% to 38%). Several newly synthesized organophosphonates were tested as new potential ...
Tópico(s): Phosphorus compounds and reactions
2022 - Multidisciplinary Digital Publishing Institute | Molecules
Mirosław Hawrył, Krystyna Skalicka‐Woźniak, Ryszard Świeboda, Małgorzata Niemiec, Klaudia Stępak, Monika Waksmundzka‐Hajnos, Anna Hawrył, Grażyna Szymczak,
Abstract Essential oils from eleven Mentha species were obtained by Deryng hydrodistillation and analysed by GC–MS: 44 compounds were identified. The most abundant were menthone, isomenthone, menthol, carvone, piperitone oxide, D-limonene and eucalyptol. Chemometric similarity measures and principal component analysis were calculated, allowing comparisons based on secondary metabolite content. The fingerprints may be helpful in chemotaxonomy.
Tópico(s): Traditional Chinese Medicine Analysis
2015 - De Gruyter Open | Open Chemistry
Iwona Krela‐Kaźmierczak, Marta Kaczmarek-Ryś, Aleksandra Szymczak‐Tomczak, Michał Michalak, Marzena Skrzypczak-Zielińska, Natalia Drwęska-Matelska, Michalina Marcinkowska, Piotr Eder, Lilianna Łykowska-Szuber, Ewa Wysocka, Krzysztof Linke, Ryszard Słomski,
Osteoporosis is more frequent in inflammatory bowel disease (IBD) patients. A reduction in bone mineral mass in these individuals is caused not only by inflammatory processes in the bowel, because osteoporosis occurs already in very young IBD patients and in newly diagnosed individuals who have not yet undergone any pharmacological treatment. One of individual determinants of the bone turnover parameters is osteoprotegerin (OPG) encoded by the TNFRSF11B gene. The c.-223C > T polymorphism in this gene ...
Tópico(s): Bone health and osteoporosis research
2016 - Springer Science+Business Media | Calcified Tissue International
Iwona Krela‐Kaźmierczak, Michał Michalak, Anna Wawrzyniak, Aleksandra Szymczak‐Tomczak, Piotr Eder, Liliana Łykowska‐Szuber, Marta Kaczmarek-Ryś, Natalia Drwęska-Matelska, Marzena Skrzypczak-Zielińska, Krzysztof Linke, Ryszard Słomski,
Tópico(s): Bone health and osteoporosis research
2017 - Springer Nature | Molecular Biology Reports
Grzegorz Kowalewski, Piotr Kaliciński, Marek Stefanowicz, Ryszard Grenda, Piotr Czubkowski, Marek Szymczak,
Chronic kidney disease (CKD) is a common complication after liver transplantation (LT). Its prevalence with modern immunosuppression regimens, especially in children, is variable depending on the transplantation era. The study included 61 pediatric patients with at least 10 years of follow-up after liver transplantation remaining under constant care of the Department of Pediatric Surgery and Organ Transplantation. The analysis included several tests: estimated glomerular function (eGFR), results of ...
Tópico(s): Liver Disease and Transplantation
2021 - Multidisciplinary Digital Publishing Institute | Children