Kiyonari Ohmura, Ryuichi Nagashima, Hiroaki Takeda, Tsuneo Takahashi,
Although benign esophageal stricture induced by various factors can often be managed with dilatation using a balloon or fixed-size dilators, some patients have esophageal stenosis that is refractory to such treatment. Endoprostheses have facilitated the palliation of malignant esophageal stricture. However, the indications for permanent esophageal stenting in patients with benign esophageal stricture have not been established because the long-term safety of endoprostheses in the esophagus is still ...
Tópico(s): Dysphagia Assessment and Management
1998 - Elsevier BV | Gastrointestinal Endoscopy
Yasuka L. Yamaguchi, Satomi Tanaka, Naoko Oshima, Hiroshi Kiyonari, Makoto Asashima, Ryuichi Nishinakamura,
Abstract The translocon‐associated protein (TRAP, also termed the signal sequence receptor) complex is required for the efficient translocation of secretory and membrane proteins in the endoplasmic reticulum, and is also involved in the endoplasmic reticulum stress‐mediated unfolded protein response pathway. To investigate the roles of Trap‐γ, a TRAP complex subunit, we generated Trap‐γ knockout mice and found that mutant pups died soon after birth because of retarded embryonic organ growth, especially ...
Tópico(s): RNA modifications and cancer
2011 - Wiley | Developmental Dynamics
Shahidul Islam, Yohei Shinmyo, Tatsuya Okafuji, Yuhong Su, Iftekhar Bin Naser, Giasuddin Ahmed, Sanbing Zhang, Sandy Chen, Kunimasa Ohta, Hiroshi Kiyonari, Takaya Abe, Satomi Tanaka, Ryuichi Nishinakamura, Toshio Terashima, Toshio Kitamura, Hideaki Tanaka,
Axon guidance proteins are critical for the correct wiring of the nervous system during development. Several axon guidance cues and their family members have been well characterized. More unidentified axon guidance cues are assumed to participate in the formation of the extremely complex nervous system. We identified a secreted protein, draxin, that shares no homology with known guidance cues. Draxin inhibited or repelled neurite outgrowth from dorsal spinal cord and cortical explants in vitro. ...
Tópico(s): Zebrafish Biomedical Research Applications
2009 - American Association for the Advancement of Science | Science
Mariam C. Recuenco, Tomoko Ohmori, Shunsuke Tanigawa, Atsuhiro Taguchi, Sayoko Fujimura, Mary Anne Conti, Qize Wei, Hiroshi Kiyonari, Takaya Abe, Robert Adelstein, Ryuichi Nishinakamura,
The kidney develops from reciprocal interactions between the metanephric mesenchyme and ureteric bud. The mesenchyme transforms into epithelia and forms complicated nephron structures, whereas the ureteric bud extends its pre-existing epithelial ducts. Although the roles are well established for extracellular stimuli, such as Wnt and Notch, it is unclear how the intracellular cytoskeleton regulates these morphogenetic processes. Myh9 and Myh10 encode nonmuscle myosin II heavy chains, and Myh9 mutations ...
Tópico(s): Pediatric Urology and Nephrology Studies
2014 - American Society of Nephrology | Journal of the American Society of Nephrology
Minoru Takasato, Chiyoko Kobayashi, Koji Okabayashi, Hiroshi Kiyonari, Naoko Oshima, Makoto Asashima, Ryuichi Nishinakamura,
Glomeruli comprise an important filtering apparatus in the kidney and are derived from the metanephric mesenchyme. A nuclear protein, Sall1, is expressed in this mesenchyme, and we previously reported that Trb2, a mouse homolog of Drosophila tribbles, is expressed in the mesenchyme-derived tissues of the kidney by microarray analyses using Sall1-GFP knock-in mice. In the present report, we detected Trb2 expression in a variety of organs during gestation, including the kidneys, mesonephros, testes, ...
Tópico(s): Birth, Development, and Health
2008 - Elsevier BV | Biochemical and Biophysical Research Communications
Takahito Nakama, Shigeo Yoshida, Keijiro Ishikawa, Yoshiyuki Kobayashi, Takaya Abe, Hiroshi Kiyonari, Go Shioi, Naruto Katsuragi, Tatsuro Ishibashi, Ryuichi Morishita, Yoshiaki Taniyama,
Retinal neovascularization (NV) due to retinal ischemia is one of the major causes of vision reduction in patients with different types of retinal diseases although anti-vascular endothelial growth factor (anti-VEGF) therapy can partially reduce the size of the retinal NV. We recently reported that periostin plays an important role in the development of NV and the formation of preretinal fibrovascular membranes, but the role of the splice variants of periostin on retinal NV has not been determined. ...
Tópico(s): Retinal Development and Disorders
2016 - Elsevier BV | Experimental Eye Research
Ken Yamashita, Shinichi Kiyonari, Shoma Tsubota, Satoshi Kishida, Ryuichi Sakai, Kenji Kadomatsu,
Abstract MYCN gene amplification is consistently associated with poor prognosis in patients with neuroblastoma, a pediatric tumor arising from the sympathetic nervous system. Conventional anticancer drugs, such as alkylating agents and platinum compounds, have been used for the treatment of high‐risk patients with MYCN ‐amplified neuroblastoma, whereas molecule‐targeting drugs have not yet been approved. Therefore, the development of a safe and effective therapeutic approach is highly desired. Although ...
Tópico(s): Neuroendocrine Tumor Research Advances
2020 - Wiley | Cancer Science
Masaji Sakaguchi, Sazia Sharmin, Atsuhiro Taguchi, Tomoko Ohmori, Sayoko Fujimura, Takaya Abe, Hiroshi Kiyonari, Yoshihiro Komatsu, Yuji Mishina, Makoto Asashima, Eiichi Araki, Ryuichi Nishinakamura,
Most kidney nephron components, including glomeruli and renal tubules, derive from the metanephric mesenchyme. The overall differentiation into each component finishes at birth, but the molecular events linking the perinatal and adult kidneys remain elusive. Dullard was cloned from Xenopus kidneys, and encodes a phosphatase that negatively regulates BMP signalling. Here we report that Dullard deletion in the murine metanephric mesenchyme leads to failure of nephron maintenance after birth, resulting ...
Tópico(s): Renal cell carcinoma treatment
2013 - Nature Portfolio | Nature Communications
E Morikawa, Masayuki Yasutomi, Katsuhisa Shindou, Taiji Matsuda, N Mori, Jin‐ichi Hida, Ryuichi Kubo, Masanori Kitaoka, Masato Nakamura, Kiyonari Fujimoto, Haruhiko Inufusa, Masaki Hatta, Gentaro Izumoto,
PURPOSE: The aim of this study was to clarify the distribution of lymph node metastasis in colorectal cancer. We also examined the relationship between the primary tumor (T) and the regional node (N) categories of the TNM (primary tumor, regional nodes, metastasis) classification. METHOD: Lymph nodes of surgical specimens in 311 consecutive patients with colorectal cancer were studied using the modified clearing method. RESULTS: Lymph node metastasis was seen in 59.2 percent of the total cases. The ...
Tópico(s): Gastric Cancer Management and Outcomes
1994 - Lippincott Williams & Wilkins | Diseases of the Colon & Rectum
Yukako Uchiyama, Masaji Sakaguchi, Takeshi Terabayashi, Toshiaki Inenaga, Shuji Inoue, Chiyoko Kobayashi, Naoko Oshima, Hiroshi Kiyonari, Naomi Nakagata, Yuya Sato, Kiyotoshi Sekiguchi, Hiroaki Miki, Eiichi Araki, Sayoko Fujimura, Satomi Tanaka, Ryuichi Nishinakamura,
The kidney develops through reciprocal interactions between two precursor tissues: the metanephric mesenchyme and the ureteric bud. We previously demonstrated that the zinc finger protein Sall1 is essential for ureteric bud attraction toward the mesenchyme. Here, we show that Kif26b , a kinesin family gene, is a downstream target of Sall1 and that disruption of this gene causes kidney agenesis because of impaired ureteric bud attraction. In the Kif26b -null metanephros, compact adhesion between mesenchymal ...
Tópico(s): Genetic and Kidney Cyst Diseases
2010 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Takashi Shinozaki, Ryuichi Watanabe, Kentaro Kawatsu, Kiyonari Sakurada, Shinya Takahi, Ken‐ichi Ueno, Ryoji Matsushima, Toshiyuki Suzuki,
麻痺性貝毒の規制値である4 MU/gに相当する毒力を持つマガキ（Crassostrea gigas）の抽出液を代替標準品として大阪府立公衆衛生研究所が開発した麻痺性貝毒簡易測定キット（PSP-ELISA）を使ったスクリーニング検査の有効性を検証した．2007～2010年に熊本県海域で採取したマガキ試料をPSP-ELISAで測定したところ，PSP-ELISAと公定法の結果は高い相関性を示し，規制値の半量であるマウス毒力2 MU/g以下でも十分検出できるため，マガキの毒化予察に十分役立つことが分かった．また，マガキ抽出液を蛍光化HPLCで分析したところ，監視期間中のマガキの毒組成は一定であった．以上の結果から，スクリーニング基準値を2 MU/g（PSP-ELISA）と設定した．熊本県海域ではこの基準値であれば，規制値以上のマウス毒力を持つマガキを確実に検出できることから，本モニタリング法の有効性が明らかになった．
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2013 - Japanese Society for Food Hygiene and Safety | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
Yoshifumi Fujioka, Hirosuke Shiura, Masayuki Ishii, Ryuichi Ono, Tsutomu Endo, Hiroshi Kiyonari, Yoshikazu Hirate, Hikaru Ito, Masami Kanai‐Azuma, Takashi Kohda, Tomoko Kaneko‐Ishino, Fumitoshi Ishino,
Tópico(s): Epigenetics and DNA Methylation
2025 - Royal Society | Open Biology