Yasuhiro Nakadaira, Ryuji Sato, Hideki Sakurai,
... RETURN TO ISSUEPREVArticleNEXTPreparation and structure of silacycloheptatrieneYasuhiro Nakadaira, Ryuji Sato, and Hideki SakuraiCite this: Organometallics 1991, 10, 2, ...
Tópico(s): Molecular Junctions and Nanostructures
1991 - American Chemical Society | Organometallics
Yoshitaka Iso, Teruko Soda, Takatoshi Sato, Ryuji Sato, Taro Kusuyama, Yasutoshi Omori, Makoto Shoji, Shinji Koba, Takashi Katagiri, Youichi Kobayashi, Hiroshi Suzuki,
The aim of this study is to identify which factors influence limb salvage after bone marrow mononuclear cell implantation (BMI) in patients with chronic critical limb ischemia (CLI).Thirteen no-option CLI patients treated with BMI were enrolled in the present study. Limb ischemia was assessed using the ankle-brachial index (ABI), transcutaneous oxygen tension (TcO(2)), and rest pain score. The cell populations among the implanted cells were determined by May-Giemsa staining and flow cytometry.Major ...
Tópico(s): Lymphatic System and Diseases
2009 - Elsevier BV | Atherosclerosis
A dynamic binary neural network is a simple two-layer network with a delayed feedback and is able to generate various binary periodic orbits. The network is characterized by the signum activation function, ternary connection parameters, and integer threshold parameters. The ternary connection brings benefits to network hardware and to computation costs in numerical analysis. In order to stabilize a desired binary periodic orbit, a simple evolutionary algorithm is presented. The algorithm uses individuals ...
Tópico(s): Chaos control and synchronization
2017 - Elsevier BV | Neurocomputing
Shigeo Saito, Ying‐Chu Lin, Ming‐Ho Tsai, Chang‐Shen Lin, Yoshinobu Murayama, Ryuji Sato, Kazunari K. Yokoyama,
Abstract Eukaryotic organisms require oxygen homeostasis to maintain proper cellular function for survival. During conditions of low oxygen tension (hypoxia), cells activate the transcription of genes that induce an adaptive response, which supplies oxygen to tissues. Hypoxia and hypoxia‐inducible factors (HIFs) may contribute to the maintenance of putative cancer stem cells, which can continue self‐renewal indefinitely and express stemness genes in hypoxic stress environments (stem cell niches). Reactive ...
Tópico(s): Pluripotent Stem Cells Research
2015 - Wiley | The Kaohsiung Journal of Medical Sciences
Katsuyuki Tomita, Hiroyuki Sano, Yasutaka Chiba, Ryuji Sato, Akiko Sano, Osamu Nishiyama, Takashi Iwanaga, Yuji Higashimoto, Ryuta Haraguchi, Yuji Tohda,
To predict the presence of asthma in adult patients with respiratory symptoms, we developed a scoring algorithm using clinical parameters. We prospectively analysed 566 adult outpatients who visited Kinki University Hospital for the first time with complaints of nonspecific respiratory symptoms. Asthma was comprehensively diagnosed by specialists using symptoms, signs, and objective tools including bronchodilator reversibility and/or the assessment of bronchial hyperresponsiveness (BHR). Multiple ...
Tópico(s): Allergic Rhinitis and Sensitization
2013 - Springer Nature | Primary Care Respiratory Journal
Ryuji Sato, Katsuyuki Tomita, Hiroyuki Sano, Hideo Ichihashi, Shigeyoshi Yamagata, Akiko Sano, Toshiyuki Yamagata, Takayuki Miyara, Takashi Iwanaga, Masato Muraki, Yuji Tohda,
Background. Various factors have been reported to be useful for predicting future exacerbations. Objective. This study was intended to determine a usefulness of a combination of a patient-based questionnaire, such as the Asthma Control Test (ACT) score with objective assessments, such as forced expiratory volume in 1 second (FEV1) and/or exhaled nitric oxide (FENO), for predicting future exacerbations in adult asthmatics. Methods. We therefore enrolled 78 subjects with mild to moderate asthma, who ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2009 - Taylor & Francis | Journal of Asthma
Yoshihiro Kaneko, Ryuji Sato, Hideki Aoyagi,
Pharmaceutical manufacturing plants can be operated continuously for several months. It is therefore important to use cells with long-term stability for the production of active ingredients. We investigated the reliability and long-term stability of an antibody-producing cell line. A recombinant Chinese hamster ovary (CHO) cell line was cultivated in spinner flasks and reactors, including a practical production-scale reactor (1600 L), for 109 days to produce monoclonal antibodies against the HM1.24 ...
Tópico(s): Protein purification and stability
2009 - Elsevier BV | Journal of Bioscience and Bioengineering
Yoshihiro Kaneko, Ryuji Sato, Hideki Aoyagi,
Although overproduction of recombinant proteins by mammalian cells is well established, little attention has been paid to analysis of the quality of the products. We focused on the quality of antibodies produced during the death phase of a recombinant Chinese hamster ovary (CHO) cell line. The quality of the monoclonal antibody against HM1.24 antigen and the post-translational characteristics of the subunits during CHO cell culture in a 160-L bioreactor were investigated. The culture supernatant ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2009 - Elsevier BV | Journal of Bioscience and Bioengineering
Yoshiyuki Ban, Takuya Watanabe, Toshiaki Suguro, Taka‐aki Matsuyama, Yoshitaka Iso, Tetsuo Sakai, Ryuji Sato, Tsunenori Idei, Yasuko Nakano, Hidekazu Ota, Akira Miyazaki, Nobumasa Kato, Tsutomu Hirano, Yoshio Ban, Youichi Kobayashi,
Aim: Human urotensin-II (UII) is a cyclic neuropeptide with potent vasoconstrictive activity in the vasculature. The expression of UII and its receptor (UT) mRNA is detected at high levels in the brain. We evaluated the relationship between plasma UII levels and vascular dementia (VaD) caused by stroke or atherosclerotic small vessel disease.Methods: Carotid artery intima-media thickness (IMT), plaques, plasma levels of immunoreactive UII (IR-UII), and atherosclerotic biomarkers were determined in 42 ...
Tópico(s): Cardiovascular Disease and Adiposity
2009 - Japan Atherosclerosis Society | Journal of Atherosclerosis and Thrombosis
Shunsuke Yamagata, K. Tomita, Ryuji Sato, Akira Niwa, Hideaki Higashino, Yuji Tohda,
Interleukin (IL)-18, which is produced by activated monocytes/macrophages and airway epithelial cells, is suggested to contribute to the pathophysiology of asthma by modulating airway inflammation. However, the involvement of IL-18 on modulating chronic airway inflammation and airway remodelling, which are characterized in a refractory asthma model exposed to long-term antigen, has not been investigated sufficiently. We examined the role of IL-18 in chronic airway inflammation and airway remodelling ...
Tópico(s): Respiratory and Cough-Related Research
2008 - Oxford University Press | Clinical & Experimental Immunology
Hiroshi Suzuki, Taro Kusuyama, Ryuji Sato, Y Yokota, F. Tsunoda, Takatoshi Sato, Makoto Shoji, Yoshitaka Iso, Shinji Koba, Takashi Katagiri,
Interleukin-6 (IL-6) and metalloproteinases (MMPs) are involved in the instability of vulnerable plaque associated with the induction of acute myocardial infarction (AMI). We examined the regional changes of cytokines, MMPs and adhesion molecules in patients with AMI to elucidate how these factors are involved in the onset of AMI.One hundred and twenty-two patients with AMI were included. Blood was aspirated from the culprit coronary artery with a thrombectomy catheter, and was also sampled from peripheral ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2008 - Wiley | European Journal of Clinical Investigation
Mikio Fujiwara, Kazuhide Kumagai, Makoto Segawa, Ryuji Sato, Yuichi Tamura,
Tópico(s): Electric and Hybrid Vehicle Technologies
2008 - | SAE technical papers on CD-ROM/SAE technical paper series
Tsuyoshi Honma, Rie Ihara, Yasuhiko Benino, Ryuji Sato, Takumi Fujiwara, Takayuki Komatsu,
We examined the laser-induced crystallization to form the fresnoite type Ba2TiGe2O8 crystal line patterns in transition metal ion doped BaO–TiO2–GeO2 glass. Ba2TiGe2O8 crystal line was written in 0.6FeO–33.3BaO–16.7TiO2–50GeO2 glass by continuous wave yttrium–aluminum–garnet (YAG) laser irradiation. We obtained polarization dependence of Raman spectra in crystal line pattern. Second harmonic generation (SHG) indicated unique fringe patterns from Ba2TiGe2O8 crystal lines.
Tópico(s): Building materials and conservation
2007 - Elsevier BV | Journal of Non-Crystalline Solids
Tsuyoshi Honma, Yasuhiko Benino, Takumi Fujiwara, Takayuki Komatsu, Ryuji Sato,
The glass formation region, crystalline phases, second harmonic (SH) generation, and Nd:yttrium aluminum garnet (YAG) laser‐induced crystallization in the Sm 2 O 3 –Bi 2 O 3 –B 2 O 3 system were clarified. The crystalline phases of Bi 4 B 2 O 9 , Bi 3 B 5 O 12 , BiBO 3 , Sm x Bi 1− x BO 3 , and SmB 3 O 6 were formed through the usual crystallization in an electric furnace. The crystallized glasses consisting of BiBO 3 and Sm x Bi 1− x BO 3 showed SH generations. The formation of the nonlinear optical BiB 3 ...
Tópico(s): Crystal Structures and Properties
2005 - Wiley | Journal of the American Ceramic Society
Rie Ihara, Tsuyoshi Honma, Yasuhiko Benino, Takumi Fujiwara, Ryuji Sato, Takayuki Komatsu,
Two-dimensional crystal curved lines consisting of the nonlinear optical SmxBi1−xBO3 phase are fabricated at the surface of 8Sm2O3·37Bi2O3·55B2O3 glass by continuous wave Nd:YAG laser (wavelength: 1064 nm) irradiation (samarium atom heat processing) with a power of ∼0.9 W and a laser scanning speed of 5 μm/s. The curved lines with bending angles of 0–90° or with sine-shapes are written by just changing the laser scanning direction. The polarized micro-Raman scattering spectra for the line after bending ...
Tópico(s): Photorefractive and Nonlinear Optics
2005 - Elsevier BV | Solid State Communications
Hiroshi Suzuki, Ryuji Sato, Takatoshi Sato, Makoto Shoji, Yoshitaka Iso, Takeshi Kondo, Masayuki Shibata, Shinji Koba, Takashi Katagiri,
Although cytokine elevation has been demonstrated in chronic heart failure, little attention has been focused on cytokine levels during the acute stage. We examined the changes of cytokine levels in patients with acutely decompensated heart failure to investigate their relationship with severity of heart failure.Patients with acutely decompensated heart failure (73 patients; 72+/-2 years) were included. Blood samples were taken from the peripheral vein on admission before the start of drug therapy, ...
Tópico(s): Signaling Pathways in Disease
2005 - Elsevier BV | International Journal of Cardiology
Hiroshi Ohnishi, Yuka Kaneko, Hideki Okazawa, Motoaki Miyashita, Ryuji Sato, Akiko Hayashi, Kazutoshi Tada, Shigekazu Nagata, Masami Takahashi, Takashi Matozaki,
Polarized localization of membrane proteins to axons or dendrites is important for a variety of neuronal functions, including neurite outgrowth and synaptogenesis during neural development. Src homology 2 domain-containing protein tyrosine phosphatase (SHP) substrate-1 (SHPS-1) and its ligand cluster of differentiation 47 (CD47), both of which are members of the Ig superfamily of proteins, are thought to constitute an intercellular communication system in the CNS, although the physiological functions ...
Tópico(s): Lipid Membrane Structure and Behavior
2005 - Society for Neuroscience | Journal of Neuroscience
Toru Sugiyama, Takanobu Yoshimoto, Yuki Hirono, Noriko Suzuki, Maya Sakurada, Kyoichiro Tsuchiya, Isao Minami, Fumiko Iwashima, Haruna Sakai, Toru Tateno, Ryuji Sato, Yukio Hirata,
Aldosterone is currently recognized as one of the important risk hormones for cardiovascular disease. However, the cellular mechanism by which aldosterone affects the process of cardiovascular injury has not been well understood. In the present study, we investigated whether aldosterone induces pro-inflammatory genes expression in rat aortic endothelial cells. Aldosterone significantly increased steady-state osteopontin mRNA and protein levels, but not those of adhesion molecules or chemokine. The ...
Tópico(s): Vitamin K Research Studies
2005 - Elsevier BV | Biochemical and Biophysical Research Communications
Takanobu Yoshimoto, Nozomi Fukai, Ryuji Sato, Toru Sugiyama, Naoko Ozawa, Masayoshi Shichiri, Yukio Hirata,
Abstract Recent adrenomedullin (AM) gene-targeting studies have proposed a novel concept that AM plays a protective role against oxidative stress in vivo. The present study was undertaken to explore the underlying molecular mechanism of the putative antioxidant action of AM against angiotensin II (Ang II)induced reactive oxygen species (ROS) generation in rat vascular smooth muscle cells (VSMCs). Intracellular ROS levels were measured by dichlorofluoroscein fluorescence. Redox-sensitive c-Jun amino- ...
Tópico(s): Renin-Angiotensin System Studies
2004 - Oxford University Press | Endocrinology
Nozomi Fukai, Takanobu Yoshimoto, Toru Sugiyama, Naoko Ozawa, Ryuji Sato, Masayoshi Shichiri, Yukio Hirata,
Adrenomedullin (AM) expressed by and secreted from a variety of cells plays pluripotent roles in an autocrine/paracrine fashion. The present study was undertaken to explore the expression of AM and its receptor genes in adipose tissues, their changes during the development of obesity, and the process of preadipocyte differentiation. Both mature adipocytes and stromal vascular cells constituting adipose tissue expressed AM transcript. AM and its receptor component [calcitonin receptor-like receptor ...
Tópico(s): Hormonal Regulation and Hypertension
2004 - American Physiological Society | AJP Endocrinology and Metabolism
Toru Sugiyama, Takanobu Yoshimoto, Ryuji Sato, Nozomi Fukai, Naoko Ozawa, Masayoshi Shichiri, Yukio Hirata,
Since both endothelin-1 (ET-1) and aldosterone have been shown to induce expression of several pro-inflammatory genes, including cyclooxygenase-2 (COX-2), in the vasculature as a cardiovascular risk hormone, the present study was undertaken to examine the effects of ET-1 and aldosterone on COX-2 gene expression as measured by a real-time reverse transcriptasepolymerase chain reaction in aortic endothelial cells. Treatment with ET-1(10-7M) markedly upregulated COX-2 mRNA levels in rat endothelial cells, ...
Tópico(s): Hormonal Regulation and Hypertension
2004 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Hiroshi Ohnishi, Hisae Kobayashi, Hideki Okazawa, Yoshihide Ohe, Kyoko Tomizawa, Ryuji Sato, Takashi Matozaki,
SHPS-1 is a transmembrane protein whose cytoplasmic region undergoes tyrosine phosphorylation and then binds the protein-tyrosine phosphatase SHP-2. Formation of the SHPS-1-SHP-2 complex is implicated in regulation of cell migration. In addition, SHPS-1 and its ligand CD47 constitute an intercellular recognition system that contributes to inhibition of cell migration by cell-cell contact. The ectodomain of SHPS-1 has now been shown to be shed from cells in a reaction likely mediated by a metalloproteinase. ...
Tópico(s): Galectins and Cancer Biology
2004 - Elsevier BV | Journal of Biological Chemistry
Ryuji Sato, Hiroshi Ohnishi, Hisae Kobayashi, Daisuke Kiuchi, Akiko Hayashi, Yuka Kaneko, Nakayuki Honma, Hideki Okazawa, Yukio Hirata, Takashi Matozaki,
SHPS-1 is a receptor-type transmembrane glycoprotein, which contains four tyrosine residues in its cytoplasmic region, and the phosphorylation of these tyrosine residues serves the binding sites for SHP-2 protein–tyrosine phosphatase. Its extracellular region interacts with another membrane protein, CD47, thereby constituting a cell–cell communication system. We analyzed this ligand–receptor interaction using Chinese hamster ovary (CHO) cells expressing wild-type (WT) or mutant SHPS-1. The binding ...
Tópico(s): Complement system in diseases
2003 - Elsevier BV | Biochemical and Biophysical Research Communications
Tsuyoshi Honma, Yasuhiko Benino, Takumi Fujiwara, Takayuki Komatsu, Ryuji Sato,
Crystal lines with second-order optical nonlinearity have been successfully fabricated at the surface of 10Sm2O3.35Bi2O3.55B2O3 glass by continuous irradiation of Nd:YAG laser. The laser-induced crystalline phase was confirmed to be Bi0.7Sm0.3BO3 by x-ray diffraction measurements, and second-harmonic generation (SHG) from the phase was clearly observed. An array structure of crystal lines was fabricated by laser writing under automatic computer control, and Maker fringe patterns of SHG were observed, ...
Tópico(s): Advanced Surface Polishing Techniques
2003 - American Institute of Physics | Applied Physics Letters
Masaru Doi, Taihei Imai, Masayoshi Shichiri, TOHRU TATENO, Nozomi Fukai, Naoko Ozawa, Ryuji Sato, Kenichi Teramoto, Yukio Hirata,
We report a 21-year-old woman with ectopic ACTH syndrome due to islet cell carcinoma with multiple liver metastases. On admission, she showed Cushingoid appearance (moon face, central obesity etc.) and had acute respiratory distress syndrome due to pneumocystis carinii pneumonia. Laboratory examination revealed marked elevations of plasma ACTH (735 pg/ml) and cortisol (145 microg/dl) with a profound hypokalemia (2.0 mEq/l). She was found to have multiple masses in the liver and a solid mass in the tail ...
Tópico(s): Neuroblastoma Research and Treatments
2003 - Japan Endocrine Society | Endocrine Journal
Tsuyoshi Honma, Yasuhiko Benino, Takumi Fujiwara, Takayuki Komatsu, Ryuji Sato,
The technique for the writing of crystal lines in glass by Nd:YAG laser irradiation, selective atom heat processing, is applied to rare-earth (Sm3+, Dy3+) barium borate glasses, and nonlinear optical β-BaB2O4 (β-BBO) crystal lines with a width of ∼5 μm are fabricated. The crystal lines show uniform colors in polarized optical microscope and second-harmonic generation (SHG) measurements. The azimuthal dependence of SHG signals in the crystal lines is the same as that in commercially available β-BBO bulk ...
Tópico(s): Laser Material Processing Techniques
2003 - American Institute of Physics | Applied Physics Letters
Tsuyoshi Honma, Yasuhiko Benino, Takumi Fujiwara, Ryuji Sato, Takayuki Komatsu,
New transparent surface crystallized glasses in the system of Sm2O3-Bi2O3-B2O3 have been successfully fabricated. The second harmonic generation (SHG) from the crystalline phase at the surface layers has been confirmed from Maker fringe measurements. The irradiation of CW YAG laser with a wavelength of 1064 nm induces sharp refractive-index changes or crystalline dot formation, depending on Sm2O3 content in the glasses. In 10Sm2O3⋅30Bi2O3⋅60B2O3 glass, refractive-index changes (not crystallites) are ...
Tópico(s): Phase-change materials and chalcogenides
2002 - Ceramic Society of Japan | Journal of the Ceramic Society of Japan
Shuji Mukae, Shuichi Aoki, Seiji Itoh, Ryuji Sato, Kazuaki Nishio, Toshiki Iwata, Takashi Katagiri,
A single nucleotide polymorphism of mitochondrial 5178A/C, causing a Met to Leu replacement within the NADH dehydrogenase subunit, is reported to be associated with longevity. The purpose of the present study was to assess the contribution of mitochondrial polymorphisms, particularly the 5178A/C genotype, to the susceptibility to acute myocardial infarction (AMI) in a Japanese study population. There were 4 groups: 150 patients with AMI, 150 with essential hypertension, 100 with diabetes mellitus, ...
Tópico(s): Mitochondrial Function and Pathology
2002 - Japanese Circulation Society | Circulation Journal
Hisashi Kotani, Masaya Narasaki, Ryuji Sato, Toshio Yamanaka,
A growing number of high-rise apartment buildings each with a light well in the center of them are designed in accordance with the structural design and planning for the last 10 years in Japan. This light well is defined as an intermediate space between outdoor and indoor. The questionnaire surveys to four apartment buildings that have different sizes of the light well were conducted to make clear the occupants' evaluation about the actual environmental conditions. As a result, the environment of ...
2002 - Elsevier BV | Building and Environment
Shuji Mukae, Seiji Itoh, Shuichi Aoki, T Iwata, Kae Nishio, Ryuji Sato, Takashi Katagiri,
The use of angiotensin-converting enzyme (ACE) inhibitors to treat hypertension has recently increased. However, their use is associated with a persistent dry cough in a significant percentage of such patients. The present study was designed to assess the contribution of polymorphisms as a genetic marker of ACE-inhibitor-related cough in a Japanese hypertensive population. Genotyping was carried out in 190 patients, 70 with cough and 120 without cough, who had been treated with ACE inhibitors. Polymorphisms ...
Tópico(s): Heart Failure Treatment and Management
2002 - Springer Nature | Journal of Human Hypertension