John Dugdale, Dave Podmore, Michael Prescott, Christopher Middleton, Rhoda Koenig, Barbara Hall, Adrian Room, R C, John Birt, Bryan Rouse, John Jay City Editor, Jon Swain, A G, H M, Steve McNie, C A L, John Peter, D A, J K, Pam Barrett, Mark Reason, Lesley White, John Jay, Susan d'Arcy, Mark Souster, Max Glaskin, J W L, Stephen Bayley, Frank Whitford, Dave Lawrenson, Anne Campbell, Ivo Tennant, Nicolette Jones, I M, C G T, P D, David Smith, Humphrey Carpenter, B G, Penny Wark, David James Smith, P H L, Andrew Sullivan, Clive Davis, R M S, Stephen Grey, Mary Wilson, Father John Buckley, Leslie Craven, Claudia Dudman, Anne Griffin, R J E, Steve Ball, Ann Tusa, Martin James, D C, Peter Hamilton, Iain Johnstone, B M, P O, J B B, Irwin Stelzer, R Baxter, Peter Wilson, Roger Anderson, George Turnbull, Julian Barnes, David Dougill, C H, N Vincent, John Evans, R T N B, Muriel Spark, David Hewson, G P, Harvey Porlock, Randeep Ramesh, Margaret Coles, Lucie Messenger, Hugh Mcllvanney, Margarette Driscoll, Hugh Canning, Jeremy Clarkson, Stewart Lee, Edward Porter, Peter Conradi, John Melmoth, Louise Taylor, M P, Jeannette Kupfermann, Robert Harris, Michael Jones, Mrs O B, Kingsley Fielding, Liz Jones, J G, Jenny King, Jim Gallagher, Adam Courtenay, George Perry, J Y, Cathy Scott-Clark, Graham Otway, Robin Marlar, Charlotte Atkins, Nick Gardner, Shelley von Strunckel, Rob Steen, Bernard Cafferty, Mike Laws, Hywel Davies, Paul Ham, Stuart Wavell, K W, Paul Donovan, Sue Lawrence, Dag Pike, Jeff Randall, Jonathan Sale, Paul Driver, James Adams, Olga Craig, J C R, Maeve Sheehan, Nicholas Hellen, Ian Hawkey, Ian Chadband, Andrei Eldon-Edington, David Leppard, Neil Mackwood, Tim Kelsey, Andrian Levy, Tom Shone, Rufus Olins, Cathy Scott-Clark Education Correspondent, J R S, Jacqueline Fuller, T D, Dave Thomas, Andy Goldberg, Mark Slater, Phil Baker, John Harlow Arts Correspondent, Jonathan Annells, Adam Jones, Christina Lamb, Jack Nicholson, M A, C L, John Karter, Elizabeth McFariane, Simon Kaminsky, M F W, R E, Uki Goni, Andrew Roberts, Alix Ramsay, Diana Wright, Nik Cohn, N B, Michael Nyman, R W, Helen Hawkins, Rebecca Tanqueray, H H, Stephen Jones, N H, Richard Evans, I C, Caroline Merrell, R C C W, M H, Andrew Neil, Andrew Smith, Paul Nuki, Andrew Grice, Hugh McManners, Steve Connor Science Correspondent, Martin Searby, Rob Ryan, Claire Oldfield, Ian Critchley, Andrew Castle, David Torvell, Jeremy Paxman, David Watchman, Rasselas, Trevor Lewis, Kevin Cruickshank, Steven Haynes, Jason Thompson, Lois Rogers Medical Correspondent, Colin McDowell, Montagu Bream, Nicholas Fox, Stephen Armstrong, Simon Edmond, Christopher Goodwin, Alex Ogle, K B, D H, Roland White, John Kennedy, Garth Alexander, T T, William Rees-Mogg, Joanna Pitman, David Redhead, J R G, Maurice Chittenden, Kevin Pratt, David Rudnick, Andrew Lorenz Business Editor, Mark Franchetti, Ray Hutton, Sara Banerji, Heather Boreham, G S, S J, Peter Watts, Jonathan Leake, Tom Mair, Fiona Matthias, Michael Sheridan, Sean Hargrave, Margaret Buntrock, John Harlow, Matthew Lynn, Godfrey Smith, K M, Susan Anspach, D L, Andrew Alderson, John Waples, Tony Rudd, A A Gill, Ray Hammond, Peter Hildreth, Sarah Harris, John Carey, Rajeev Syal, C E, Kirsty Lang, Damien Sarsfield, Jacqueline Owen, Superintendent Ian Latimer, D A D, Chrissy Iley, Robert Johnston, Stephen Pettitt, R M, Kevin Goldstein-Jackson, Gilbert Adair, R H, Andrew Lorenz, Andre Agassi, Liam Clarke, Adrian Levy, Mumina Saburah, David Wickers, Roger Dobson, Anthony Haden-Guest, May Leigh, Mark Hodson, Christopher Higgins, P W, Joe Lovejoy, Frank Whiteford, Rupert Steiner, John Sheffield, Chris Lightbown, Hugh Pearman, J Z, Bob Murray, J R, Simon Sebag Montefiore, J H, John Phillips, H F, Simon Townley, C T, John Burns, David Smith Economics Editor, Hugh Bradley, Victor Oliver, Flona Matthlas, P G, Simon Reeve, Carla Powell, Martin Booth, Peter Roebuck, Carey Scott, Hugo Charlton, Walter Ellis, Stephen Boyd, Joanna Simon, India Knight, Douglas Kennedy, Andrew Palmer, Dan Pearson, Stephen Hayward, Louise McKee, Boris Schapiro,
... Gallery Marita Koch Athlete, East Germany, b. 1957 Sandor Kocsis Footballer, Hungary, 1929-1979 Gunji Koizumi Judo fighter, ...
1996 - Gale Group | Sunday Times HA GDA
Pál Kocsis, Sándor Farkas, László Fodor, Norbert Bielik, Márta Thán, Sándor Kolok, Anikó Gere, Mónika Csejtei, István Tarnawa,
The spinal reflex depressant mechanism of tolperisone and some of its structural analogs with central muscle relaxant action was investigated. Tolperisone (50–400 μM), eperisone, lanperisone, inaperisone, and silperisone (25–200 μM) dose dependently depressed the ventral root potential of isolated hemisected spinal cord of 6-day-old rats. The local anesthetic lidocaine (100–800 μM) produced qualitatively similar depression of spinal functions in the hemicord preparation, whereas its blocking effect ...
Tópico(s): Neuroscience and Neuropharmacology Research
2005 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Dániel Petrovszki, Fruzsina R. Walter, Judit P. Vigh, Anna E. Kocsis, Sándor Valkai, Mária A. Deli, András Dér,
Since the outbreak of the global pandemic caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), several clinical aspects of the disease have come into attention. Besides its primary route of infection through the respiratory system, SARS-CoV-2 is known to have neuroinvasive capacity, causing multiple neurological symptoms with increased neuroinflammation and blood-brain barrier (BBB) damage. The viral spike protein disseminates via circulation during infection, and when reaching the brain ...
Tópico(s): Molecular Communication and Nanonetworks
2022 - Multidisciplinary Digital Publishing Institute | Biomedicines
Zsolt Kotroczó, Katalin Juhos, Borbála Bíró, Tamás Kocsis, Sándor Attila Pabar, Csaba Varga, István Fekete,
Soil organic matter supply is mainly derived from plant litter. The early stages of litter degradation is a very dynamic process. Thus, its study is important for understanding litter degradation and the control factors of different biomes and ecosystems. In the frame of the Síkfőkút DIRT (Detritus Input and Removal Treatments) Project, the effect of organic matter treatment was studied on the rate of decomposition of organic matter by applying different kinds of organic materials (leaf and wood litter, ...
Tópico(s): Soil and Water Nutrient Dynamics
2020 - Multidisciplinary Digital Publishing Institute | Forests
J. Karger‐Kocsis, Sándor Kéki,
Shape memory polymer (SMP) is capable of memorizing one or more temporary shapes and recovering successively to the permanent shape upon various external stimuli. Beside of the above mentioned one-way variants, also two-way shape memory polymers (SMPs) and shape memory (SM) systems exist which feature a reversible shape change on the basis of “on-off switching” of the external stimulus. The preparation, properties and modelling of shape memory epoxy resins (SMEP), SMEP foams and composites have been ...
Tópico(s): Polyoxometalates: Synthesis and Applications
2017 - Multidisciplinary Digital Publishing Institute | Polymers
J. Karger‐Kocsis, Sándor Kéki,
Shape memory polymers (SMPs) are capable of memorizing one or more temporary shapes and recovering to the permanent shape upon an external stimulus that is usually heat.Biodegradable polymers are an emerging family within the SMPs.This minireview delivers an overlook on actual concepts of molecular and supramolecular architectures which are followed to tailor the shape memory (SM) properties of biodegradable polyesters.Because the underlying switching mechanisms of SM actions is either related to ...
Tópico(s): Marine Biology and Environmental Chemistry
2014 - Budapest University of Technology and Economics | eXPRESS Polymer Letters
Nóra Faragó, Ágnes K. Kocsis, Sándor Lovas, Gábor Molnár, Eszter Boldog, Márton Rózsa, Viktor Szemenyei, Enikő Vámos, L Nagy, Gábor Tamás, László G. Puskás,
Whole-cell patch-clamp recording enables detection of electrophysiological signals from single neurons as well as harvesting of perisomatic RNA through the patch pipette for subsequent gene expression analysis. Amplification and profiling of RNA with traditional quantitative real-time PCR (qRT-PCR) do not provide exact quantitation due to experimental variation caused by the limited amount of nucleic acid in a single cell. Here we describe a protocol for quantifying mRNA or miRNA expression in individual ...
Tópico(s): RNA Interference and Gene Delivery
2013 - Future Science Ltd | BioTechniques
D Afra, Béla Kocsis, Sándor Kerpel‐Fronius, Sándor Eckhardt,
Tópico(s): Neuroblastoma Research and Treatments
1986 - Springer Science+Business Media | Journal of Neuro-Oncology
Ozge Gunduz‐Cinar, Anna Rizzi, Anna Baldisserotto, Remo Guerrini, Barbara Spagnolo, Elaine C. Gavioli, László Kocsis, Anna Magyar, Sándor Benyhe, Anna Borsodi, Girolamo Calò,
It was recently reported that the hexapeptide Ac-RYYRIK-ol binds with high affinity nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptors and competitively antagonizes N/OFQ actions in the mouse vas deferens assay. Here we further describe the in vitro and in vivo pharmacological features of this NOP receptor ligand. In mouse brain homogenate the degradation half life of Ac-RYYRIK-ol (2.48 min) was significantly higher than that of the parent compound Ac-RYYRIK-NH2 (1.20 min). In the electrically stimulated ...
Tópico(s): Receptor Mechanisms and Signaling
2006 - Elsevier BV | European Journal of Pharmacology
Nóra Faragó, Ágnes K. Kocsis, Csilla Braskó, Sándor Lovas, Márton Rózsa, Judith Baka, Balázs Kovács, Katalin Mikite, Viktor Szemenyei, Gábor Molnár, Attila Ozsvár, Gáspár Oláh, Ildikó Piszár, Ágnes Zvara, Attila Patócs, Pál Barzó, László G. Puskás, Gábor Tamás,
Functional and molecular changes associated with pathophysiological conditions are relatively easily detected based on tissue samples collected from patients. Population specific cellular responses to disease might remain undiscovered in samples taken from organs formed by a multitude of cell types. This is particularly apparent in the human cerebral cortex composed of a yet undefined number of neuron types with a potentially different involvement in disease processes. We combined cellular electrophysiology, ...
Tópico(s): Single-cell and spatial transcriptomics
2016 - Springer Science+Business Media | Acta Neuropathologica Communications
Tibor Nagy, Borbála Antal, Katalin Czifrák, Ildikó Papp, J. Karger‐Kocsis, Miklós Zsuga, Sándor Kéki,
ABSTRACT The uncatalyzed reactions of 2,4‐TDI (2,4‐ toluenediisocyanate ) and MDI (4,4 ′ ‐ diphenylmethane‐diisocyanate ) with alcohols including butan‐1‐ol, butan‐2‐ol, diethylene glycol monomethylether (DEGME) were studied by high ‐ performance liquid chromatography (HPLC) and electrospray ionization mass spectrometry (ESI‐MS). The reactions were carried out at different temperatures from 22°C to 75°C using high molar ratios of alcohols to diisocyanates. It was found that the first isocyanate group of the MDI ...
Tópico(s): Carbon dioxide utilization in catalysis
2015 - Wiley | Journal of Applied Polymer Science
Gábor Molnár, Nóra Faragó, Ágnes K. Kocsis, Márton Rózsa, Sándor Lovas, Eszter Boldog, Rita Báldi, Éva Csajbók, János Gardi, László G. Puskás, Gábor Tamás,
Concentrations of insulin in the brain are severalfold higher than blood plasma levels. Insulin in the brain regulates the metabolism, molecular composition, and cognitive performance of microcircuits and reduces food intake; cerebral insulin levels are altered in diabetes, aging, obesity, and Alzheimer's disease. Released by pancreatic β cells, insulin passes the blood-brain barrier, but sources of locally released insulin still remain unclear. We find that insulin is strongly expressed in GABAergic ...
Tópico(s): Neuroscience and Neuropharmacology Research
2014 - Society for Neuroscience | Journal of Neuroscience
Ferenc Zádor, Dóra Kocsis, Anna Borsodi, Sándor Benyhe,
There is a growing number of evidence showing, that the cannabinoid receptor 1 (CB1) antagonist rimonabant has many non-cannabimimetic actions, such as affecting the opioid system. The direct effect of rimonabant on opioid receptors has been studied so far mainly on μ-opioid receptors. However recently the δ-opioid receptor (DOR) receives much more attention as before, due to its potential therapeutic applications, such as nociception or treatment for psychiatric disorders. To investigate the direct ...
Tópico(s): Neuropeptides and Animal Physiology
2014 - Elsevier BV | Neurochemistry International
Zsuzsanna Pluhár, Marianna Kocsis, Anett Kuczmog, Sándor Csete, Hella Simkó, Szilvia Sárosi, Péter Molnár, Györgyi Horváth,
Tópico(s): Plant Pathogens and Fungal Diseases
2012 - Akadémiai Kiadó | Acta Biologica Hungarica
D Afra, Béla Kocsis, Jozsef Dobay, Sándor Eckhardt,
✓ Within 4 weeks after definitive surgery, 91 patients with supratentorial glioblastomas and malignant astrocytomas were randomized to one of three treatment arms: Group 1 received radiotherapy alone; Group 2 received dibromodulcitol (DBD) during radiotherapy, and treatment was then continued with DBD; and Group 3 received DBD during radiotherapy, followed by combination chemotherapy of CCNU and DBD. No severe myelotoxicity occurred, but combined treatment with CCNU and DBD occasionally caused a transient ...
Tópico(s): Management of metastatic bone disease
1983 - American Association of Neurological Surgeons | Journal of neurosurgery
Cs. Lakatos, Katalin Czifrák, R. Papp, J. Karger‐Kocsis, Miklós Zsuga, Sándor Kéki,
Segmented linear polyurethanes (PUs) containing Diels-Alder (DA) adduct were synthesized in toluene solution from poly("-caprolactone) (PCL, M n = 10, 25 and 50 kg/mol), diisocyanate (methylene diphenyl diisocyanate (MDI), 2,4toluene diisocyanate (TDI), 1,6-hexamethylenediisocyanate, (HDI)), furfurylamine (FA) and bismaleimide (BMI).The order of the segments in the PUs was -PCL-MDI-FA-BMI-.The PUs were characterized by size-exclusion chromatography (SEC), different spectroscopic ( 1 H-NMR, attenuated total reflectance ...
Tópico(s): Photochromic and Fluorescence Chemistry
2016 - Budapest University of Technology and Economics | eXPRESS Polymer Letters
Marianna Kocsis, Sándor B. Ötvös, Gergely F. Samu, Zsolt Fogarassy, B. Pécz, Ákos Kukovecz, Zoltán Kónya, Pál Sipos, István Pálinkó, Gábor Varga,
An efficient self-supported Cu(II)Bi(III) bimetallic catalyst with a layered structure was designed and developed. By careful characterization of the as-prepared material, the host structure was identified to exhibit a Sillen-type bismutite framework, with copper(II) ions being loaded as guests. The heterogeneous catalyst enabled C–N and C–S arylations under mild reaction conditions and with high chemoselectivities, thus furnishing valuable phenothiazines via heterocyclization with wide substrate ...
Tópico(s): Chemical Synthesis and Reactions
2021 - American Chemical Society | ACS Applied Materials & Interfaces
Tópico(s): Advances in Oncology and Radiotherapy
2017 - Akadémiai Kiadó | Orvosi Hetilap
Katalin Czifrák, Csilla Lakatos, J. Karger‐Kocsis, Lajos Daróczi, Miklós Zsuga, Sándor Kéki,
The present work aimed at the preparation and investigation of different epoxy-polyurethane (EP-PU) co-networks. The EP-PU co-networks were obtained by applying two different synthetic strategies, in which the coupling element, the Diels–Alder (DA) adduct, was prepared previously or formed “in situ” in the reaction between furan functionalized polyurethane and furfuryl amine-diglycidyl ether bisphenol-A oligomers (FA_DGEBA). For the synthesis of these EP-PU networks, poly(ε-caprolactone)-diol (PCD, Mn = ...
Tópico(s): Polydiacetylene-based materials and applications
2018 - Multidisciplinary Digital Publishing Institute | Polymers
Balázs Juhász, Katalin Gulyás, Ágnes Horváth, Zoltán Pethő, Harjit Pal Bhattoa, Andrea Váncsa, É. Szekanecz, C Horváth, Judit Kocsis, Zsolt Horváth, Katalin Hodosi, Sándor Szántó, Gabriella Szücs, Zoltán Szekanecz,
Tópico(s): Spondyloarthritis Studies and Treatments
2016 - Springer Science+Business Media | Osteoporosis International
Csilla Lakatos, Katalin Czifrák, J. Karger‐Kocsis, Lajos Daróczi, Miklós Zsuga, Sándor Kéki,
ABSTRACT Crosslinked polyurethanes (PUs) containing irreversible (allophanate) and reversible Diels‐Alder chemical bonds were synthesized using various diisocyanates (methylene diphenyl diisocyanate MDI, 1,6‐hexamethylenediisocyanate HDI) and poly(ɛ‐caprolactone) ((PCL) with different molecular weights ( M n = 10 kg/mol, 25 kg/mol, 50 kg/mol) as diol component. The melting/crystallization of PCL and the reversible DA bonds acted as temperature‐activated switches for shape memory performances, while allophanate ...
Tópico(s): Marine Sponges and Natural Products
2016 - Wiley | Journal of Applied Polymer Science
Ákos Kuki, Katalin Czifrák, J. Karger‐Kocsis, Miklós Zsuga, Sándor Kéki,
Tópico(s): Advanced Materials and Mechanics
2015 - Springer Science+Business Media | Mechanics of Time-Dependent Materials
Márton Csernai, Sándor Borbély, Kinga Kocsis, Dávid Burka, Z. Fekete, Veronika Balogh, Szabolcs Káli, Zsuzsa Emri, Péter Barthó,
Key points Sleep spindle frequency positively, duration negatively correlates with brain temperature. Local heating of the thalamus produces similar effects in the heated area. Thalamic network model corroborates temperature dependence of sleep spindle frequency. Brain temperature shows spontaneous microfluctuations during both anesthesia and natural sleep. Larger fluctuations are associated with epochs of REM sleep. Smaller fluctuations correspond to the alteration of spindling and delta epochs ...
Tópico(s): Photoreceptor and optogenetics research
2019 - Wiley | The Journal of Physiology
Tamás Mankovits, István Budai, G Balogh, András Gábora, István Kozma, Tamás Varga, Sándor Manó, Imre Kocsis,
The development of an efficient procedure for 3d modeling and finite element simulation of metal foams is one of the greatest challenges for engineer researchers nowadays. Creating 3d CAD model is alone a demanding engineering task due to its extremely complex geometry, and the proper finite element analysis process is still in the center of the research. The increasingly widespread application of the metal foams, e.g. in vehicle and medical industry, requires this knowledge in the design phase. ...
Tópico(s): 3D Shape Modeling and Analysis
2014 - Akadémiai Kiadó | International Review of Applied Sciences and Engineering
E. Tyihák, Lajos Botz, Péter G. Ott, Sándor Nagy, Béla Kocsis, Zs. Király-Véghely, Emil Mincsovics,
BioArena is a complex separation and detection system, which integrates the advantages of the overpressured layer chromatography (OPLC) and bioautography. It exploits the interaction possibilities between the microbes andthe dye substance as well as other small and big co-factor molecules in the sorbent bed aver separation. OPLC separation resulted in the increase of the sensitivity and the compactness of the spots in comparison to the conventional TLC-HPTLC separations. OPLC and bioautography as ...
Tópico(s): Chromatography in Natural Products
2003 - Polish Chemical Society | Chemia Analityczna
Sándor Nagy, Béla Kocsis, Tamás Kőszegi, Lajos Botz,
Tópico(s): bioluminescence and chemiluminescence research
2002 - Springer Science+Business Media | JPC - Journal of Planar Chromatography - Modern TLC
Tibor Nagy, Borbála Antal, Anita Dékány-Adamoczky, J. Karger‐Kocsis, Miklós Zsuga, Sándor Kéki,
The reactivities of various polymer polyols towards MDI were evaluated using MALDI-TOF mass spectrometry.
Tópico(s): Carbon dioxide utilization in catalysis
2016 - Royal Society of Chemistry | RSC Advances
Gyula Kovács, Pál Kocsis, István Tarnawa, C Horváth, Zsolt Szombathelyi, Sándor Farkas,
Windup, the frequency dependent build-up of spinal neuronal responses, is implicated in the development of central sensitization of nociceptive pathways. N-methyl-D-aspartate (NMDA) receptors have been shown to be involved in these processes but the role of various receptor subtypes at the spinal level is not fully understood. In our experiments, we compared the inhibitory effect of MK-801 (a nonselective NMDA receptor antagonist, 0.01-3 mg/kg i.v.) and CI-1041 (an NR2B subunit specific NMDA receptor ...
Tópico(s): Ion channel regulation and function
2003 - Elsevier BV | Neuropharmacology
Mahmoud Al‐Khrasani, György Orosz, László Kocsis, Viktor Farkas, Anna Magyar, Imre Lengyel, Sándor Benyhe, Anna Borsodi, András Z. Rónai,
The opioid properties of endomorphin derivatives containing a C-terminal alcoholic(-ol) function were compared to the parent amidated compounds in isolated organs (longitudinal muscle strip of guinea-pig ileum and mouse vas deferens). Similar data were also generated for the μ-opioid receptor selective agonist synthetic peptide (d-Ala2, MePhe4, Gly5-ol)-enkephalin (DAMGO) and its Gly5-NH2 congener (DAMGA). Endomorphin-1-ol (Tyr-Pro-Trp-Phe-ol) had an IC50 of 80.6 nM in mouse vas deferens and 61.2 nM ...
Tópico(s): Pain Mechanisms and Treatments
2001 - Elsevier BV | European Journal of Pharmacology
Balázs Stercz, Ferenc Balázs Farkas, Ákos Tóth, Márió Gajdács, Judit Domokos, Viola Horváth, Eszter Ostorházi, Nóra Makra, Béla Kocsis, János Juhász, Balázs Ligeti, Sándor Pongor, Dóra Szabó,
Great efforts have been made to limit the transmission of carbapenemase-producing Enterobacteriaceae (CPE), however, the intestinal reservoir of these strains and its modulation by various antibiotics remain largely unexplored. Our aim was to assess the effects of antibiotic administration (ampicillin, ceftazidime, ciprofloxacin) on the establishment and elimination of intestinal colonization with a CTX-M-15 ESBL and OXA-162 carbapenemase producing Klebsiella pneumoniae ST15 (KP5825) in a murine (C57BL/ ...
Tópico(s): Enterobacteriaceae and Cronobacter Research
2021 - Nature Portfolio | Scientific Reports