Miruna Radu-Lefebvre, Sébastien Ronteau, Vincent Lefèbvre, Maura McAdam,
Following Alistair Anderson’s legacy of entrepreneuring as a process of becoming, this paper engages with entrepreneuring as emancipation in a family business context. Over a period of seven years, we witnessed the journey of a family business successor engaged in a challenging process of power transfer, ultimately leading him to leave the succession process to engage with entrepreneuring outside the family business, due to power struggles. We theoretically elaborate on this real-time, multi-informant, ...
Tópico(s): Entrepreneurship Studies and Influences
2022 - Taylor & Francis | Entrepreneurship and Regional Development
Sébastien Lefebvre, Clémentine Harma, J.-L. Blin,
... Station, 28 av. Foch, 62930 Wimereux, France *Email: sebastien.lefebvre@unicaen.fr ABSTRACT: Our objective was to use ...
Tópico(s): Marine and fisheries research
2009 - Inter-Research | Marine Ecology Progress Series
Pierre‐Marie Coulon, Blandine Alloing, Virginie Brändli, Denis Lefebvre, Sébastien Chenot, J. Zúñiga‐Pérez,
Site‐controlled growth of GaN nanowires (NWs) on GaN‐on‐sapphire templates with a patterned SiN mask has been carried out by metalorganic vapor phase epitaxy using a continuous‐flow growth mode. A low V/III ratio compared to that used for GaN layer growth, combined with low precursor flow rates for both Ga and N precursors, has been used to promote the nanowire growth on Ga‐polar substrates. The lateral growth rate, that is, perpendicular to the c ‐axis, could be further controlled using appropriate ...
Tópico(s): Nanowire Synthesis and Applications
2015 - Wiley | physica status solidi (b)
A. Gay, Fabien Lefèbvre, Sébastien Bergamo, Frédéric Valiorgue, Pierre Chalandon, Philippe Michel, Ph. Bertrand,
Lightweight structures are more and more widely used in the automotive industry due to the growing importance of environment regulations related to CO2 emissions. In this context of saving weight, composites offer an alternative to metals because they can achieve a better stiffness to weight ratio. A problematic becomes crucial: which process can be used to join efficiently composite and metallic parts? An innovative way would be the application of self-piercing riveting to thermoplastic composite– ...
Tópico(s): Fatigue and fracture mechanics
2015 - Elsevier BV | International Journal of Fatigue
Yuxin Ma, Tania Fort, Armelle Marais, Marie Lefebvre, Sébastien Theil, Corinne Vacher, Thierry Candresse,
Abstract Plants are colonized by diverse fungal and viral communities that influence their growth and survival as well as ecosystem functioning. Viruses interact with both plants and the fungi they host. Our understanding of plant–fungi–virus interactions is very limited, especially in wild plants. Combining metagenomic and culturomic approaches, we assessed the richness, diversity, and composition of leaf‐associated fungal and viral communities from pools of herbaceous wild plants representative ...
Tópico(s): Mycorrhizal Fungi and Plant Interactions
2021 - Wiley | Plant-Environment Interactions
Nelcis Zora, Thomas Rigaux, Jean-Christophe Buvat, Dimitri Lefebvre, Sébastien Leveneur,
The influence of inlet parameters on the production and thermal risk of complex chemical systems can be cumbersome to evaluate. To determine the optimum safe operating conditions, one needs to solve complex differential equations derived from energy and material balances. This robust approach cannot be made on-site, and it is essential to propose simplest tools to evaluate rapidly the performance and safety of some operating conditions. This is the aim of this paper that establishes explicit relationships ...
Tópico(s): Lignin and Wood Chemistry
2021 - Elsevier BV | Journal of Loss Prevention in the Process Industries
Yuxin Ma, Armelle Marais, Marie Lefebvre, Sébastien Theil, Laurence Svanella-Dumas, Chantal Faure, Thierry Candresse,
Metagenomic studies have indicated that the diversity of plant viruses was until recently far underestimated. As important components of ecosystems, there is a need to explore the diversity and richness of the viruses associated with plant populations and to understand the drivers shaping their diversity in space and time. Two viral sequence enrichment approaches, double-stranded RNA (dsRNA) and virion-associated nucleic acids (VANA), have been used and compared here for the description of the virome ...
Tópico(s): Bacteriophages and microbial interactions
2019 - American Society for Microbiology | Journal of Virology
Claire Champenois, Vincent Lefèbvre, Sébastien Ronteau,
This paper provides a Systematic Literature Review ('SLR') of the emerging 'entrepreneurship-as-practice' (EaP) research field. It advances EaP as a 'platform of expression' that enriches entrepreneurship research. Following the 'practice turn' in social sciences, entrepreneurship is also interested in this new approach. The goal of this article is to map and critically review the literature within the EaP field. The Systematic Literature Review returned 76 articles contributing closely to EaP. Beyond ...
Tópico(s): Management and Organizational Studies
2019 - Taylor & Francis | Entrepreneurship and Regional Development
Marie Lefebvre, Sébastien Theil, Yuxin Ma, Thierry Candresse,
Viral metagenomics relies on high-throughput sequencing and on bioinformatic analyses to access the genetic content and diversity of entire viral communities. No universally accepted strategy or tool currently exists to define operational taxonomy units (OTUs) and evaluate viral alpha or beta diversity from virome data. Here we present a new bioinformatic resource, the VirAnnot (automated viral diversity estimation) pipeline, which performs the automated identification of OTUs. Reverse-position-specific ...
Tópico(s): Genomics and Phylogenetic Studies
2019 - American Phytopathological Society | Phytobiomes Journal
Mohammed Abdelhameed, Paul‐Ludovic Karsenti, Adam Langlois, Jean‐François Lefebvre, Sébastien Richeter, Romain Ruppert, Pierre D. Harvey,
Abstract A dyad built up of a zinc(II) porphyrin and the corresponding free base, [Zn‐Fb] , fused to N‐heterocyclic carbene (NHCs) ligands, respectively acting as singlet energy donor and acceptor, and a bridging trans ‐PdI 2 unit, along with the corresponding [Zn‐Zn] and [Fb‐Fb] dimers were prepared and investigated by absorption and emission spectroscopy and density functional computations. Despite favorable structural and spectroscopic parameters, unexpectedly slow singlet energy transfer rates are ...
Tópico(s): Organic Light-Emitting Diodes Research
2014 - Wiley | Chemistry - A European Journal
François Lefebvre, Sébastien Wielgoss, Kazuya Nagasawa, František Moravec,
The nematode Anguillicoloides crassus is one of the many threats hanging over anguillid eels, now known to infect six Anguilla species worldwide. It was first described in Japan, in 1974, and is commonly thought to natively stem from East Asia. Here our primary objective was to critically evaluate this long-held statement. We first retraced the factual history of this global invader, to later investigate the pros and cons for an East Asian origin. After exploring the alternative scenarios for the ...
Tópico(s): Fish biology, ecology, and behavior
2012 - Regional Euro-Asian Biological Invasions Centre (REABIC) | Aquatic Invasions
Lifang Mu, Lucia Berti, Giacomo Masserdotti, Marcela Covic, Theologos M. Michaelidis, Kathrin Doberauer, Katharina Merz, Frederick Rehfeld, Anja Haslinger, Michael Wegner, Elisabeth Sock, Véronique Lefèbvre, Sébastien Couillard‐Després, Ludwig Aigner, Benedikt Berninger, D. Chichung Lie,
Neural stem cells (NSCs) generate new hippocampal dentate granule neurons throughout adulthood. The genetic programs controlling neuronal differentiation of adult NSCs are only poorly understood. Here we show that, in the adult mouse hippocampus, expression of the SoxC transcription factors Sox4 and Sox11 is initiated around the time of neuronal commitment of adult NSCs and is maintained in immature neurons. Overexpression of Sox4 and Sox11 strongly promotes in vitro neurogenesis from adult NSCs, ...
Tópico(s): Developmental Biology and Gene Regulation
2012 - Society for Neuroscience | Journal of Neuroscience
Marco Delgado, Françoise Delbecq, Catherine C. Santini, F. Lefebvre, Sébastien Norsic, Piotr Putaj, Philippe Sautet, Jean‐Marie Basset,
In this study, the nature of the hydroxyl groups present on γ-alumina, γ-Al2O3, pretreated at various temperatures has been reinvestigated by 1H NMR spectroscopy. The peaks are assigned by comparison between experimental and simulated spectra, in agreement with previous IR studies. The lowest chemical shifts δ correspond to OH groups strongly bound to the most acidic Al atoms (AlIV and AlV). High chemical shifts δ are assigned to OH groups making hydrogen bonds. A large range of values is found depending ...
Tópico(s): Mesoporous Materials and Catalysis
2011 - American Chemical Society | The Journal of Physical Chemistry C
Grégory Lefebvre, Sébastien Desfarges, Frédéric Uyttebroeck, Miguel Muñoz, Niko Beerenwinkel, Jacques Rougemont, Amalio Telenti, Angela Ciuffi,
ABSTRACT Next-generation sequencing offers an unprecedented opportunity to jointly analyze cellular and viral transcriptional activity without prerequisite knowledge of the nature of the transcripts. SupT1 cells were infected with a vesicular stomatitis virus G envelope protein (VSV-G)-pseudotyped HIV vector. At 24 h postinfection, both cellular and viral transcriptomes were analyzed by serial analysis of gene expression followed by high-throughput sequencing (SAGE-Seq). Read mapping resulted in 33 ...
Tópico(s): RNA Research and Splicing
2011 - American Society for Microbiology | Journal of Virology
Tony Lefebvre, Sébastien Pinte, Cateline Guérardel, Sophie Deltour, Nathalie Martin‐Soudant, Marie‐Christine Slomianny, Jean‐Claude Michalski, Dominique Leprince,
HIC1 (hypermethylated in cancer 1) is a transcriptional repressor containing five Krüppel‐like C 2 H 2 zinc fingers and an N‐terminal dimerization and autonomous repression domain called BTB/POZ. Here, we demonstrate that full‐length HIC1 proteins are modified both in vivo and in vitro with O‐linked N ‐acetylglucosamine ( O ‐GlcNAc). This is a highly dynamic glycosylation found within the cytosolic and the nuclear compartments of eukaryotes. Analysis of [ 3 H]Gal‐labeled tryptic peptides indicates that ...
Tópico(s): RNA modifications and cancer
2004 - Wiley | European Journal of Biochemistry
Mariëlle C. Haks, Stanley M. Belkowski, Maria Ciofani, Michele Rhodes, Juliette M. Lefebvre, Sébastien Trop, Patrice Hugo, Juan Carlos Zúñiga‐Pflücker, David L. Wiest,
Abstract Pre-TCR complexes are thought to signal in a ligand-independent manner because they are constitutively targeted to lipid rafts. We report that ligand-independent signaling is not a unique capability of the pre-TCR complex. Indeed, the TCRα subunit restores development of pTα-deficient thymocytes to the CD4+CD8+ stage even in the absence of conventional MHC class I and class II ligands. Moreover, we found that pre-TCR and αβTCR complexes exhibit no appreciable difference in their association ...
Tópico(s): Erythrocyte Function and Pathophysiology
2003 - American Association of Immunologists | The Journal of Immunology
Cristina Buraga-Lefebvre, Sébastien Coëtmellec, Denis Lebrun, Cafer Özkul,
The wavelet analysis provides an efficient tool in numerous signal-processing problems and has been implemented in optical processing techniques, such as in-line holography. When the diffraction pattern recorded on a hologram is analyzed by means of a wavelet transform, the 3-D location of small particles can be determined very accurately. The diffraction process can, in fact, be interpreted as a convolution with a family of wavelet functions, or, merely, as a wavelet transform. The scale parameter ...
Tópico(s): Advanced Optical Imaging Technologies
2000 - Elsevier BV | Optics and Lasers in Engineering
Vincent Contesse, Hervé Lefèbvre, Sébastien Lenglet, Jean‐Marc Kuhn, Catherine Delarue, Hubert Vaudry,
Serotonin (5-HT) plays a pivotal role in the regulation of the brain-pituitary-adrenal axis. In particular, 5-HT has been shown to control the activity of hypothalamic CRF neurons and pituitary corticotrope cells through activation of 5-HT1A and (or) 5-HT(2A/2C) receptor subtypes. 5-HT, acting through 5-HT2 receptors, can also trigger the renin-angiotensin system by stimulating renin secretion and consequently can enhance aldosterone production. At the adrenal level, 5-HT produced locally stimulates ...
Tópico(s): Adipose Tissue and Metabolism
2000 - NRC Research Press | Canadian Journal of Physiology and Pharmacology
Vincent Contesse, Hervé Lefèbvre, Sébastien Lenglet, Jean‐Marc Kuhn, Catherine Delarue, Hubert Vaudry,
Serotonin (5-HT) plays a pivotal role in the regulation of the brain-pituitary-adrenal axis. In particular, 5-HT has been shown to control the activity of hypothalamic CRF neurons and pituitary corticotrope cells through activation of 5-HT 1A and (or) 5-HT 2A/2C receptor subtypes. 5-HT, acting through 5-HT 2 receptors, can also trigger the renin-angiotensin system by stimulating renin secretion and consequently can enhance aldosterone production. At the adrenal level, 5-HT produced locally stimulates ...
Tópico(s): Hormonal Regulation and Hypertension
2000 - NRC Research Press | Canadian Journal of Physiology and Pharmacology
Stéphane Karasiewicz, Elsa Breton, Alain Lefebvre, Tania Hernández Fariñas, Sébastien Lefebvre,
The link between harmful algal blooms, phytoplankton community dynamics and global environmental change is not well understood. To tackle this challenging question, a new method was used to reveal how phytoplankton communities responded to environmental change with the occurrence of an harmful algae, using the coastal waters of the eastern English Channel as a case study. The great interannual variability in the magnitude and intensity of Phaeocystis spp. blooms, along with diatoms, compared to ...
Tópico(s): Isotope Analysis in Ecology
2017 - Elsevier BV | Harmful Algae
Roger B. Cohen, Jérôme Fayette, Marshall R. Posner, G. Lefebvre, Jessica R. Bauman, Sébastien Salas, Caroline Even, Tanguy Y. Seiwert, Dimitrios Colevas, Antonio Jimeno, Esma Saâda, Barbara Burtness, Pascale André, Carine Paturel, Cécile Bonnafous, Anne-Marie Soulié, Anne Tirouvanziam-Martin, Robert Zerbib, Agnès Boyer-Chammard,
... Format: Roger Cohen, Jérôme Fayette, Marshall Posner, Gautier Lefebvre, Jessica Bauman, Sébastien Salas, Caroline Even, Tanguy Seiwert, Dimitrios Colevas, Antonio ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2018 - American Association for Cancer Research | Cancer Research
A. Gay, Fabien Lefèbvre, Sébastien Bergamo, Frédéric Valiorgue, Pierre Chalandon, Philippe Michel, Ph. Bertrand,
Automotive manufacturers work on the vehicle weight reduction to respect the new regulation laws about CO2 emissions. The composite material can be introduced in replacement of some metallic parts to optimize the body structure in terms of weight reduction and performance. But how to join the new composite parts with the traditional metallic parts in accordance with the body in white process requirements? The self-piercing riveting (SPR) can be an innovative method to join thermoplastic composite ...
Tópico(s): Electronic Packaging and Soldering Technologies
2015 - Elsevier BV | Procedia Engineering
Carolina Giraldo, Pierre Cresson, Kirsteen M. MacKenzie, Virginie Fontaine, Christophe Loots, Alice Delegrange, Sébastien Lefebvre,
Abstract Knowledge of the trophic structure and variability of planktonic communities is a key factor in understanding food-web dynamics and energy transfer from zooplankton to higher trophic levels. In this study, we investigated how stable isotopes of mesozooplankton species varied seasonally (winter, spring, autumn) in relation to environmental factors and plankton size classes in a temperate coastal ecosystem. Our results showed that spring is characterized by the strongest vertical and size- ...
Tópico(s): Marine and coastal ecosystems
2024 - Nature Portfolio | Scientific Reports
Camilla Liénart, Nicolas Savoye, Yann Bozec, Elsa Breton, Pascal Conan, Valérie David, Éric Feunteun, Karine Grangeré, Philippe Kerhervé, Benoît Lebreton, Sébastien Lefebvre, Stéphane L’Helguen, Laure Mousseau, Patrick Raimbault, Pierre Richard, Pascal Riera, Pierre‐Guy Sauriau, Gauthier Schaal, Fabien Aubert, Sébastien Aubin, Sabrina Bichon, Christophe Boinet, Line Bourasseau, Martine Bréret, Jocelyne Caparros, Thierry Cariou, Karine Charlier, Pascal Claquin, Vincent Cornille, Anne-Marie Corre, Laurence Costes, Olivier Crispi, Muriel Crouvoisier, Marie Czamanski, Yolanda Del Amo, Hervé Derriennic, François Dindinaud, Maïa Durozier, Vincent Hanquiez, Antoine Nowaczyk, Jérémy Devesa, Sophie Ferreira, M. Fornier, Fabrice Garcia, Nicole Garcia, Sandrine Geslin, Emilie Grossteffan, Aurore Gueux, Julien Guillaudeau, Gaël Guillou, Orianne Joly, Nicolas Lachaussée, M. Lafont, Jézabel Lamoureux, Éric Lécuyer, Jean-Paul Lehodey, David Lemeille, Cédric Leroux, Éric Macé, Eric Maria, Philippe Pineau, Franck Petit, Mireille Pujo‐Pay, Peggy Rimelin-Maury, Émmanuelle Sultan,
In coastal systems, the multiplicity of sources fueling the pool of particulate organic matter (POM) leads to divergent estimations of POM composition. Eleven systems (two littoral systems, eight embayments and semi-enclosed systems and one estuary) distributed along the three maritime façades of France were studied for two to eight years in order to quantify the relative contribution of organic matter sources to the surface-water POM pool in coastal systems. This study was based on carbon and nitrogen ...
Tópico(s): Marine Biology and Ecology Research
2017 - Elsevier BV | Progress In Oceanography
Aude Houdan, Ian Probert, K. van Lenning, Sébastien Lefebvre,
... Prymnesiophyceae) Aude Houdan1, Ian Probert1, Kees Van Lenning2, Sébastien Lefebvre1,* 1Laboratoire de Biologie et Biotechnologies Marines, Université de Caen, Esplanade de la Paix, 14032 Caen Cedex, France2Institut de Ciències del Mar, CMIMA, Passeig Marítim 37–49, 08003 Barcelona, Spain *Corresponding author. Email: s.lefebvre@iutcaen.unicaen.fr ABSTRACT: Emiliania huxleyi is a ...
Tópico(s): Marine Biology and Ecology Research
2005 - Inter-Research | Marine Ecology Progress Series
Stephen F. Kingsmore, Laurie D. Smith, Chris M. Kunard, Matthew Bainbridge, Serge Batalov, Wendy Benson, Eric Blincow, Sara Caylor, Christina Chambers, Guillermo del Angel, David Dimmock, Yan Ding, Katarzyna A. Ellsworth, Annette Feigenbaum, Erwin Frise, Robert C. Green, Lucia Guidugli, Kevin P. Hall, Christian Holm Hansen, Charlotte A. Hobbs, Scott D. Kahn, Mark J. Kiel, Lucita Van Der Kraan, Chad Krilow, Yong Hyun Kwon, Lakshminarasimha Madhavrao, Jennie Le, Sébastien Lefebvre, Rebecca Mardach, William R. Mowrey, Danny Oh, Mallory Owen, George S. Powley, Gunter Scharer, Seth Shelnutt, Mari Tokita, Shyamal Mehtalia, Albert Oriol, Stavros Papadopoulos, James C. Perry, Edwin F. Juarez, Erica Sanford Kobayashi, Steven J. Schwartz, Duke Tran, Martin G. Reese, Meredith S. Wright, Narayanan Veeraraghavan, Kristen Wigby, Mary Willis, Aaron R. Wolen, Thomas Defay,
Newborn screening (NBS) dramatically improves outcomes in severe childhood disorders by treatment before symptom onset. In many genetic diseases, however, outcomes remain poor because NBS has lagged behind drug development. Rapid whole-genome sequencing (rWGS) is attractive for comprehensive NBS because it concomitantly examines almost all genetic diseases and is gaining acceptance for genetic disease diagnosis in ill newborns. We describe prototypic methods for scalable, parentally consented, feedback- ...
Tópico(s): Congenital heart defects research
2022 - Elsevier BV | The American Journal of Human Genetics
Nathanaël Sangare, Alain Lo-Yat, Gilles Le Moullac, Laure Pecquerie, Yoann Thomas, Sébastien Lefebvre, Romain Le Gendre, Benoı̂t Beliaeff, Serge Andréfouët,
The black-lipped pearl oyster (Pinctada margaritifera) is extensively farmed in French Polynesia to produce black pearls. For a sustainable management of marine resources, studying interactions between organisms and environment, and the associated factors and processes that will impact their life cycle and thus modulate population dynamics is a major research priority. Here, we describe black-lipped pearl oyster energy acquisition and use, and its control by temperature and food concentration within ...
Tópico(s): Ocean Acidification Effects and Responses
2020 - Elsevier BV | Ecological Modelling
Helena Lopes Galasso, Sébastien Lefebvre, Catherine Aliaume, Bastien Sadoul, Myriam D. Callier,
Integrated Multi-Trophic Aquaculture (IMTA) systems have been designed to optimize nutrient and energy use, to decrease waste, and to diversify fish-farm production. Recently, the development of detritivorous aquaculture has been encouraged, as detrivores can consume organic particulate matter, reducing benthic eutrophication and the environmental footprint of aquaculture. To this end, the polychaete Hediste diversicolor is a promising species due to its broad feeding behaviour and its resistance ...
Tópico(s): Parasite Biology and Host Interactions
2020 - Elsevier BV | Ecological Modelling
Antoine Rached, Meg-Anne Moriceau, Xavier Serfaty, Sébastien Lefebvre, Virginie Lattard,
The widespread use of pesticides to control agricultural pests is a hot topic on the public scene of environmental health. Selective pest control for minimum environmental impact is a major goal of the environmental toxicology field, notably to avoid unintended poisoning in different organisms. Anticoagulant rodenticides cause abnormal blood coagulation process; they have been widely used to control rodents, allowing inadvertent primary and secondary exposure in domestic animals and non-target predatory ...
Tópico(s): Vitamin K Research Studies
2020 - Frontiers Media | Frontiers in Veterinary Science
Danette Starblanket, Sebastien Lefebvre, Marlin Legare, Jen Billan, Nicole Akan, Erin Goodpipe, Carrie Bourassa,
Over the past several years, academic discourse has included discussions around improving research methodologies, particularly related to Indigenous people. Using Western research methodologies and methods when undertaking health research with Indigenous people, in the direction of Indigenous communities, has not been very effective. This is due to the fact that Western research methodologies do not address the need to foster relationships, mutual respect, and reciprocity. Engaging Indigenous communities ...
Tópico(s): Health Policy Implementation Science
2019 - SAGE Publishing | International Journal of Qualitative Methods