Ali El-Anani, John Banger, Giorgio Bianchi, Sérgio Clementi, C. D. Johnson, Alan R. Katritzky,
It is suggested that k0(100°) at pH = 0 should be used for correlations of hydrogen exchange rates. A procedure for obtaining these k0 values is given involving successive determination of (A)k(stoich)T°; (B)k(stoich)T° at pH = 0; (C)k(stoich)(100°) at pH = 0; (D) correction for minority species reaction; and (E) correction for isotope effects. This procedure is applied to available data.
Tópico(s): Analytical Chemistry and Chromatography
1973 - Royal Society of Chemistry | Journal of the Chemical Society. Perkin transactions II
Clementina Bianchi, Sergio Tanganelli, Lorenzo Beani,
Tópico(s): Receptor Mechanisms and Signaling
1979 - Elsevier BV | European Journal of Pharmacology
Claudia L. Bianchi, Sergio Tanganelli, Giuliano Marzola, L. Beani,
Tópico(s): Nicotinic Acetylcholine Receptors Study
1982 - Springer Science+Business Media | Naunyn-Schmiedeberg s Archives of Pharmacology
Flavio Moroni, Claudia L. Bianchi, Sergio Tanganelli, G. Moneti, L. Beani,
Abstract: The release processes of endogenous Acetylcholine (ACh), γ‐aminobutyric acid (GABA), glutamate (Glu) and glutamine (GLN) were studied in superfused guinea‐pig caudatal slices. Basal ACh release remained constant for up to 2 h, while the basal release of GABA, Glu and GLN declined to half or less of its initial values after 1 h of superfusion. Electrical stimulation increased the ACh release by 700–800% and that of GABA by 80% whereas it decreased the output of Glu by 50% and failed to modify ...
Tópico(s): Olfactory and Sensory Function Studies
1981 - Wiley | Journal of Neurochemistry
Roberto Bianchi, Sergio Jara‐Díaz, Juan de Dios Ortúzar,
After twenty years of operation the Santiago Metro decided to start a new strategy of price differences by period in order to decrease congestion in the morning peak and to postpone the acquisition of new equipment. In this paper we report the results of a model specifically designed to test the impact of different price levels on patronage by period. Stated preference (SP) data was collected, focusing on three aspects: change in time of travel, price differences and comfort improvements. A goods- ...
Tópico(s): Urban and Freight Transport Logistics
1998 - Elsevier BV | Transport Policy
Maria Esposito, Paolo Gisondi, Andrea Conti, Alessandro Giunta, Micol Del Giglio, Marco Di Mercurio, Leonardo Squinello Nogueira Veneziano, G. Ferrucci, Luca Bianchi, Sergio Chimenti, Giampiero Girolomoni,
Abstract Introduction Despite the large routine use of biologic drugs in psoriasis treatment, the majority of studies do not take into consideration dose‐adjustment practice in ‘real‐life’ dermatological setting. In routine clinical practice, the disease management may include a large number of conditions requiring non‐standard dosage regimens, including dose escalation, dose reduction and/or off‐label treatment interruption. Objective The ONDA (Outcome of non‐standard dosing regimen in Psoriasis ...
Tópico(s): Autoimmune Bullous Skin Diseases
2017 - Wiley | Journal of the European Academy of Dermatology and Venereology
Produção Nacional
Revisado por pares
Maurício Bonatto Machado de Castilhos, Vanildo Luiz Del Bianchi, Sérgio Gómez-Alonso, Esteban García‐Romero, Isidro Hermosín‐Gutiérrez,
This study analyzed the volatile composition and aroma profile of BRS Carmem and BRS Violeta red wines elaborated from traditional and two alternative winemaking procedures: grape pre-drying and submerged cap. The wines contained higher concentration of acetates (ranging from 303 mg L-1 to 905 mg L-1) and ethyl and methyl esters (ranging from 138 mg L-1 to 415 mg L-1). The BRS Carmem wines were described as fruity due to the higher concentration of esters and BRS Violeta wines were described as vegetal ...
Tópico(s): Sensory Analysis and Statistical Methods
2018 - Elsevier BV | Food Chemistry
Produção Nacional
Revisado por pares
Marco Ciotti, Silvia Angeletti, Marilena Minieri, Marta Giovannetti, Domenico Benvenuto, Stefano Pascarella, Caterina Sagnelli, Martina Bianchi, Sergio Bernardini, Massimo Ciccozzi,
In late December 2019, Chinese health authorities reported an outbreak of pneumonia of unknown origin in Wuhan, Hubei Province.A few days later, the genome of a novel coronavirus was released (http://viro-logical.org/t/novel-2019-coronavirus-genome/319; Wuhan-Hu-1, GenBank accession No. MN908947) and made publicly available to the scientific community. This novel coronavirus was provisionally named 2019-nCoV, now SARS-CoV-2 according to the Coronavirus Study Group of the International Committee on ...
Tópico(s): COVID-19 diagnosis using AI
2019 - Karger Publishers | Chemotherapy
Andrea Sonaglioni, Chiara Lonati, Michele Lombardo, Elisabetta Rigamonti, G Binda, Antonio Vincenti, Gian Luigi Nicolosi, Stefano Bianchi, Sergio Harari, Claudio Anzà,
Background: Left atrial strain and strain rate parameters, measured by bidimensional-speckle tracking echocardiography, have been proposed as predictors of atrial fibrillation, stroke, congestive heart failure and cardiovascular death. However, they have not yet been tested in hypertensive disorders of pregnancy. The aim of this study was to assess the prognostic role of global left atrial peak strain (GLAPS) in a population of pregnant women with new-onset hypertension in a medium-term follow-up. ...
Tópico(s): Cardiomyopathy and Myosin Studies
2019 - Lippincott Williams & Wilkins | Journal of Hypertension
Produção Nacional
Revisado por pares
Maurício Bonatto Machado de Castilhos, Vanildo Luiz Del Bianchi, Sérgio Gómez-Alonso, Esteban García‐Romero, Isidro Hermosín‐Gutiérrez,
The present manuscript assessed the volatile and sensory profiles of BRS Rúbea and BRS Cora wines elaborated from traditional, grape pre-drying and submerged cap winemaking. The wines contained a higher concentration of acetates (257 mg L−1 to 547 mg L−1) and ethyl and methyl esters (183 mg L−1 to 456 mg L−1) in comparison with Vitis vinifera wines. PCA was applied (explaining 68.43% of the total variance), and the higher concentration of ethyl decanoate and ethyl octanoate, diethyl succinate, hydroxylinalool, ...
Tópico(s): Phytochemicals and Antioxidant Activities
2019 - Elsevier BV | Food Chemistry
L. Beani, Claudia L. Bianchi, Sergio Tanganelli, Tiziana Antonelli, Michele Simonato, Simona Rando,
In normal guinea pigs the adrenergic agonists clonidine and norepinephrine are known to inhibit directly the cortical outflow of acetylcholine (ACh) through alpha-2 receptors and to increase the cortical outflow of gamma-aminobutyric acid (GABA) through alpha-1 receptors. GABA, in turn, contributes to inhibit ACh through GABAA receptors. This scheme is changed drastically by morphine tolerance. In morphine-tolerant guinea pigs, clonidine at 7.5, 18.7 and 112 nmol/kg i.p. stimulates the cortical release ...
Tópico(s): Stress Responses and Cortisol
1988 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Augusto Orlandi, Sara Costantini, Elena Campione, Amedeo Ferlosio, A. Amantea, Luca Bianchi, Sergio Chimenti, Luigi Giusto Spagnoli,
Background Animal-type melanoma (ATM) is a rare variant of the tumor showing diffuse, heavily pigmented neoplastic cells in the dermis. Despite the high mean thickness of the lesions, reports seem to indicate a less aggressive behavior and a better survival rate for ATM compared with conventional melanoma, but the underlying pathways related to this favorable outcome are still unknown. Observations Five women and 2 men aged 20 to 92 years presented with pigmented skin nodules (n = 5) or plaques (n = 2), varying ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2009 - American Medical Association | Archives of Dermatology
Lucia Centurione, Camillo Di Giulio, M. Cacchio, Monica Rapino, Domenico Bosco, Giovanna Grifone, Nadia Sabatini, Giuseppe Bianchi, Sergio Castorina, A Antonucci, Amelia Cataldi,
From birth to aging the heart undergoes functional changes reflecting biochemical and ultrastructural modifications which imply apoptosis. This is a physiological process resulting from genetic programs closely associated with development and aging. During development apoptosis eliminates redundant cells leading to heart remodeling, while during aging it eliminates damaged or exhausted cells. In the present paper we analyze some molecular mechanisms involved with heart morphological modifications, ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2003 - Elsevier BV | Mechanisms of Ageing and Development
Elena Campione, Evelin Jasmine Paternò, Laura Diluvio, Augusto Orlandi, Luca Bianchi, Sergio Chimenti,
The cases are reported of two women patients presenting asymptomatic solitary lesions: one in the anterior tibial region of the right leg, the other on the right arm. The first patient's lesion was 3 cm in diameter and had appeared 2 years earlier as a translucent oval atrophic patch with a definite border. The second patient presented a whitish area with a lilac ring, 2.5 cm in diameter, which had appeared nearly a year earlier. Both patients had no other similar cutaneous lesions, and their family ...
Tópico(s): Dupuytren's Contracture and Treatments
2008 - Informa | Journal of Dermatological Treatment
Mattia Bianchi, Sergio Campodall’Orto, Federico Frattini, Paolo Vercesi,
A critical success factor in the practice of Open Innovation is the timely identification of opportunities for out-licensing a firm's technologies outside its core business. This can be particularly challenging for small- and medium-sized enterprise (SMEs), because of their focussed business portfolio, specialized knowledge basis, and limited financial resources that can be devoted to innovation activities. The paper illustrates a quick and easy-to-use methodology for the identification of viable ...
Tópico(s): Intellectual Property and Patents
2010 - Wiley | R and D Management
Produção Nacional
Revisado por pares
Rita de Cássia Bianchi, Sérgio Lucena Mendes, Paulo de Marco Júnior,
Abstract The objective of this study was to compare the diet of the ocelot at two sites in southeastern Brazil: the small (957 ha), isolated Caratinga Biological Station (CBS), Minas Gerais and the large (>44,000 ha) contiguous area, comprised of the Vale do Rio Doce Natural Reserve (VRDNR) and the Sooretama Biological Reserve (SBR). We collected 60 scats in CBS from January 1997 to July 2000. Small rodents, small marsupials and primates were the most important items in terms of frequency of occurrence. ...
Tópico(s): Evolution and Paleontology Studies
2010 - Taylor & Francis | Studies on Neotropical Fauna and Environment
Emanuele Rondonotti, Marco Soncini, C.M. Girelli, G. Ballardini, G Bianchi, Sergio Brunati, L. Centenara, P. Cesari, C.C. Cortelezzi, Simona Curioni, Claudio Gozzini, R. Gullotta, M. Lazzaroni, M. Maino, Giovanna Mandelli, N. Mantovani, E. Morandi, C. Pansoni, W. Piubello, R. Putignano, R. Schalling, M. Tatarella, Federica Villa, P. Vitagliano, Antonio Russo, Dario Conte, E. Masci, Roberto de Franchis,
Data about small bowel capsule endoscopy (SBCE) come from studies involving small and highly selected populations. The study aim was to describe extent of use, indications, results, complications, and practical issues of SBCE in clinical practice in a Northern Italian Region (Lombardia).Twenty-three out of 29 invited centers fulfilled a specific questionnaire.Between 2001 and 2008, 2921 procedures were performed and both the number of centers performing SBCE (from 5 to 29) and the number of SBCE (from ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2010 - Lippincott Williams & Wilkins | European Journal of Gastroenterology & Hepatology
Produção Nacional
Revisado por pares
Rita de Cássia Bianchi, Sérgio Lucena Mendes,
Abstract This study demonstrates that ocelots ( Leopardus pardalis ) extensively use primates as a food resource at the Caratinga Biological Station (CBS) in Southeast Brazil. Analysis of 60 fecal samples collected over 4 years revealed predation upon the brown howler monkey ( Alouatta guariba ), the muriqui ( Brachyteles hypoxanthus ), and the brown capuchin monkey ( Cebus apella) . The most frequent items found in the fecal samples analyzed were Calomys ( n =16) and non‐identified Aves ( n =15), followed by A. guariba ( ...
Tópico(s): Wildlife Ecology and Conservation
2007 - Wiley | American Journal of Primatology
Marina Papoutsaki, Maria Sole Chimenti, Antonio Costanzo, Mark S. Talamonti, Arianna Zangrilli, Alessandro Giunta, Luca Bianchi, Sergio Chimenti,
Background Psoriasis is a chronic, genetically determined, immune-mediated, inflammatory skin disease affecting approximately 2% to 3% of the Caucasian population. Previously reported data demonstrated adalimumab to be an efficacious treatment of psoriatic arthritis and plaque-type psoriasis. Adalimumab is a fully human monoclonal antibody IgG1 against tumor necrosis factor alpha. Objective To evaluate the efficacy and safety of adalimumab, in the treatment of psoriasis patients whose disease is ...
Tópico(s): Dermatology and Skin Diseases
2007 - Elsevier BV | Journal of the American Academy of Dermatology
Catia De Felice, Annamaria Mazzotta, Maria Esposito, Luca Bianchi, Sergio Chimenti,
AbstractBackground: Etanercept is a human recombinant protein that functions as a competitive inhibitor of tumour necrosis factor‐alpha (TNF‐α), a pro‐inflammatory molecule exerting a key role in the pathogenesis of psoriatic arthritis (PsA). Methods: Seventy‐one patients affected by PsA with variable skin involvement, refractory to conventional anti‐rheumatic drugs, were treated with 50 mg etanercept subcutaneous injections twice‐weekly for 12 weeks, followed by a maintenance dose regimen of 25 mg ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2006 - Informa | Journal of Dermatological Treatment
Rosita Saraceno, Lucia Pietroleonardo, Annamaria Mazzotta, Arianna Zangrilli, Luca Bianchi, Sergio Chimenti,
Introduction: Treatment of nail psoriasis can be challenging and unsatisfactory. The aim of this study was to compare the efficacy of three different anti-TNF-α agents on nail psoriasis in patients affected by psoriasis. Materials and methods: Seventy-two patients with nail psoriasis were evaluated in this open, 24 weeks, prospective study. Patients were enrolled in three groups of treatment: adalimumab, etanercept or infliximab. Severity of nail psoriasis was assessed by the Nail Psoriasis Severity ...
Tópico(s): Autoimmune Bullous Skin Diseases
2012 - Taylor & Francis | Expert Opinion on Biological Therapy
Marco Turatti, Alberto Gajofatto, Maria Rachele Bianchi, Sérgio Ferrari, Salvatore Monaco, Maria Donata Benedetti,
Multiple sclerosis (MS) with initial neuroradiological features suggestive of brain tumour (tumour-like MS) may represent a challenging diagnosis.Among the patients seen at the MS centre of our Institution between 2000 and 2010, we identified cases presenting with a large (diameter>2 cm), well-defined lesion, suggestive of brain tumour on initial brain magnetic resonance imaging (MRI). Only patients with at least 10 years follow-up were included.Five young women with MS who presented with a tumour-like ...
Tópico(s): Microtubule and mitosis dynamics
2012 - Elsevier BV | Journal of the Neurological Sciences
R. Soda, Laura Diluvio, Luca Bianchi, Sergio Chimenti,
A 36‐year‐old‐man with a 3‐year history of alopecia areata universalis presented with severe onychodystrophy of all 20 nail plates of 1 year's duration. All fingernails and toenails showed a thin, rough, opaque and lustreless sandpapered appearance and they were brittle, friable and covered by small scales of keratin (Fig. 1a). No signs of psoriasis or lichen planus were found. Routine laboratory investigations reported normal values and no history of autoimmune disease was found. Onychomycosis was ...
Tópico(s): Skin and Cellular Biology Research
2005 - Oxford University Press | Clinical and Experimental Dermatology
Produção Nacional
Revisado por pares
Fabrício R. Santos, N. O. Bianchi, Sérgio D.J. Pena,
We surveyed several human populations worldwide with three PCR-based polymorphisms located in the human Y chromosome: the alphoid heteroduplex [alpha(h)] polymorphic system, the DYS19 microsatellite locus, and a polymorphic Alu insertion (YAP). By typing with the former two polymorphisms [alpha(h) and DYS19] we found 46 different haplotypes in 364 males from several populations worldwide. There were significant geographic differences in the distribution of the haplotypes, several of which were seen ...
Tópico(s): Race, Genetics, and Society
1996 - Cold Spring Harbor Laboratory Press | Genome Research
A. Pesenti, Michaela Rohr, M. Egidi, Paolo Rampini, Filippo Tamma, Marco Locatelli, E. Caputo, Valentina Chiesa, Anna Maria Bianchi, Sergio Barbieri, Giuseppe Baselli, Alberto Priori,
Tópico(s): Transcranial Magnetic Stimulation Studies
2004 - Springer Science+Business Media | Neurological Sciences
Alessandro Antonelli, Claudio Simeone, E. Frego, Gianfranco Minini, Umberto Bianchi, Sergio Cosciani Cunico,
Tópico(s): Gynecological conditions and treatments
2004 - Springer Science+Business Media | International Urogynecology Journal
M. Kozàkovà, C. Morizzo, Vanessa Bianchi, Sergio Marchetti, Giovanni Federico, Carlo Palombo,
Background and aims Childhood obesity promotes adverse changes in cardiovascular structure and function. This study evaluated whether these changes are related to intra-abdominal adiposity and associated cardiometabolic risk or to body-size induced hemodynamic overload. Methods and results 55 obese children/adolescents and 35 healthy-weight controls underwent carotid, cardiac and abdominal ultrasound to assess carotid artery intima-media thickness (IMT), diameter, distension and stiffness, left ventricular ( ...
Tópico(s): Cardiovascular Function and Risk Factors
2015 - Elsevier BV | Nutrition Metabolism and Cardiovascular Diseases
Marco Galluzzo, S. D’Adamio, Stella Servoli, Luca Bianchi, Sergio Chimenti, Mark S. Talamonti,
The identification of a number of psoriasis-susceptibility genes and a better understanding of the pathogenesis of the intracellular metabolic pathways, have generated new perspectives on psoriasis treatment, in particular new compounds that inhibit certain intracellular proteins involved in the immune response. In contrast to biologic agents, these compounds block intracellular targets such as transcriptional factors or enzymes.Tofacitinib is a small molecule that acts as a reversible, competitive ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2016 - Taylor & Francis | Expert Opinion on Pharmacotherapy
Andrea Chiricozzi, Arianna Zangrilli, Mauro Bavetta, Luca Bianchi, Sergio Chimenti, Rosita Saraceno,
Observational studies in daily practice are an essential complement to pivotal randomised controlled trials because their findings refer to larger and more diverse patient populations with common comorbidities, complex medical history, concomitant medications and longer follow-up periods.To evaluate long-term clinical outcomes of the anti-TNF-α monoclonal antibody, adalimumab, in patients with psoriasis (PsO) or psoriatic arthritis (PsA) referring to an Italian dermatological centre.Single-centre ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2016 - Wiley | Journal of the European Academy of Dermatology and Venereology
Giovanna D’Amico, Giuseppe Bianchi, Sergio Bernasconi, L Bersani, Lorenzo Piemonti, Silvano Sozzani, Alberto Mantovani, Paola Allavena,
Dendritic cells (DC) are migratory cells which exhibit complex trafficking properties in vivo, involving interaction with vascular and lymphatic endothelium and extracellular matrix (ECM). The underlying mechanisms involved in these processes are still ill defined. In the present study we have investigated the ability of DC to interact in vitro with human vascular endothelial cells (EC) and ECM. DC were differentiated from monocytes by in vitro exposure to granulocyte-macrophage colony-stimulating ...
Tópico(s): T-cell and B-cell Immunology
1998 - Elsevier BV | Blood