Pedro M. Costa, Ana L. Cardoso, Liliana Mendonça, Angelo Serani, Carlos Custódia, Mariana Conceição, Sérgio Simões, João Nuno Moreira, Luís Pereira de Almeida, Maria C. Pedroso de Lima,
The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was covalently coupled to liposomes encapsulating antisense oligonucleotides (asOs) or small interfering RNAs (siRNAs). The resulting targeted nanoparticles, designated CTX-coupled stable nucleic acid lipid particles ( ...
Tópico(s): MicroRNA in disease regulation
2013 - Cell Press | Molecular Therapy — Nucleic Acids
Produção Nacional
Revisado por pares
Marcos Almeida Bezerra, André L. B. Conceição, Sérgio L.C. Ferreira,
Tópico(s): Electrochemical Analysis and Applications
2006 - Springer Science+Business Media | Microchimica Acta
Produção Nacional
Revisado por pares
Marcos Almeida Bezerra, André L. B. Conceição, Sérgio L.C. Ferreira,
This paper proposes a preconcentration procedure for determination of nickel in saline aqueous waste samples by flame atomic absorption spectrometry (FAAS). It is based on cloud-point extraction of nickel(II) ions as 2-(5-bromo-2-pyridylazo)-5-diethilaminophenol (Br-PADAP) complexes using octylphenoxypolyethoxyethanol (Triton X-114) as surfactant. The optimisation step was performed using a four-variable Doehlert design, involving the factors centrifugation time (CT) of system after addition of surfactant, ...
Tópico(s): Pesticide Residue Analysis and Safety
2003 - Springer Science+Business Media | Analytical and Bioanalytical Chemistry
... a conflictAimée Obolari Durço, Karina Oliveira Mota, Lino Sergio Rocha Conceição, andDiego Santos Souza16 November 2023 | Journal of Applied ...
Tópico(s): Sepsis Diagnosis and Treatment
2023 - American Physiological Society | Journal of Applied Physiology
Produção Nacional
Revisado por pares
Elias Ferreira Pôrto, Alessandro Leipnitz Domingues, Anselmo Cordeiro de Souza, Mônica Karla Vojta Miranda, Morenilza Bezerra da Conceição Froes, Sérgio Rosa Vieira Pasqualinoto,
Em 26 de fevereiro de 2020, o Ministério da Saúde confirmou o primeiro caso de óbito por Covid-19 no Brasil. Este estudo objetivou-se identificar a mortalidade pela doença no Brasil nas 6 primeiras semanas após a confirmação do primeiro caso de óbito e traçar o perfil desses indivíduos. Trata-se de um estudo transversal descritivo retrospectivo, que utilizou dados dos boletins diários do Ministério da Saúde. Foram analisados todos os casos de óbitos ocorrido no Brasil por Covid-19, do dia 17 de ...
Tópico(s): Education during COVID-19 pandemic
2021 - Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências | Research Society and Development
M. Duro, Maria Conceição Manso, Sérgio V. P. Barreira, Irene Rebelo, Rui Medeiros, C Almeida,
The objective of this study was to investigate the factors underlying the development of metabolic syndrome (MetS) in HIV-infected patients. Two hundred and sixty-six clinical cases were selected for a retrospective study. The sample was classified using the Adult Treatment Panel III guidelines and the identification of risk or protective factors associated with MetS evaluated via multivariate logistic or multinomial regressions. HIV-infected individuals diagnosed with MetS tend to be older, overweight, ...
Tópico(s): HIV Research and Treatment
2018 - SAGE Publishing | International Journal of STD & AIDS
Pedro Guimarães, Pedro Rodrigues, Conceição Lobo, Sérgio Leal, João Figueira, Pedro Serranho, Rui Bernardes,
Two-dimensional images computed from three-dimensional optical coherence tomography (OCT) data are intrinsically aligned with it, allowing to accurately position a retinal OCT scan within the ocular fundus. In this work, we aim to compute an OCT fundus reference image with improved retinal vasculature extension and contrast over traditional approaches. Based on the shadow casted by hemoglobin on the outer layers of the retina, we compute three independent images from the OCT volumetric data (including ...
Tópico(s): Retinal Diseases and Treatments
2014 - Elsevier BV | Computerized Medical Imaging and Graphics
Produção Nacional
Revisado por pares
Eloá Mangabeira Santos, Carlos Alberto de Carvalho Fraga, Alessandra Rejane Ericsson de Oliveira Xavier, Mauro Aparecido de Sousa Xavier, Marcela Gonçalves de Souza, Sabrina Ferreira de Jesus, Alfredo Maurício Batista de Paula, Lucyana Conceição Farias, Sérgio Henrique Sousa Santos, Tiago G. Santos, Flávio H. Beraldo, André Luiz Sena Guimarães,
Abstract Background Head and neck squamous cell carcinoma (HNSC) etiopathogenesis remains unclear, and the biological changes with the activation of heat shock proteins (HSPs) and prion protein (PRNP) promoted by hypoxia in HNSC are undetermined. This study investigates hypoxia's effect in lymph node metastasis by PRNP expression changes and its main partners. Methods The study combined a theoretical/cell culture study with a case‐control study. First, bioinformatics and cell culture were performed. ...
Tópico(s): Cancer-related Molecular Pathways
2021 - Wiley | Journal of Oral Pathology and Medicine
Produção Nacional
Revisado por pares
Mansueto Gomes Neto, André Rodrigues Durães, Lino Sérgio Rocha Conceição, Michelli Bernardone Saquetto, Iura Gonzalez Nogueira Alves, Neil A. Smart, Vitor Oliveira Carvalho,
What are the effects of different types of exercise treatments on oxygen consumption, quality of life and mortality in people with coronary heart disease?
Tópico(s): Heart Rate Variability and Autonomic Control
2024 - Elsevier BV | Journal of physiotherapy
Produção Nacional
Ismael de Jesus Matos Viégas, Milton Garcia Costa, Eric Victor de Oliveira Ferreira, Nilda Leonor Pezo Pérez, Henrique da Silva Barata, Jessivaldo Rodrigues Galvão, Heráclito Eugênio Oliveira da Conceição, Sérgio Dias do Espírito Santo,
The use of cover crops has become a common practice in oil palm plantations, ensuring greater sustainability to agroecosystems, increasing nutrient cycling and providing greater savings in the use of mineral fertilizers. In this sense, the objective of this study was to evaluate the accumulation of macronutrients (N, P, K, Ca, Mg and S) in tropical kudzu plants (Pueraria phaseoloides L.) in oil palm plantations. The experiment was carried out in the municipality of Tailândia, Pará State, using a completely ...
Tópico(s): Agricultural and Food Sciences
2021 - | Journal of Agricultural Studies
Produção Nacional
Déborah Santos Conceição, Sérgio Baxter Andreoli, Monique Azevedo Esperidião, Darci Neves dos Santos,
to describe the profile of care for children and adolescents withpsychoactive substance use disorders performed by the Brazilian Psychosocial Care Centers (Centros de Atenção Psicossocial - CAPS) from 2008 to 2012.a descriptive study with data from the SUS Outpatient Information System (Sistema de Informações Ambulatoriais do Sistema Único de Saúde - SIA/SUS) and the system of National Registration of Health Establishments (Cadastro Nacional de Estabelecimentos de Saúde - CNES).a total of 151.330 attendances ...
Tópico(s): Youth, Drugs, and Violence
2018 - MINISTÉRIO DA SAÚDE | Epidemiologia e Serviços de Saúde
Helena M. Galvão, M.P. Reis, Elisabete Valério, Rita B. Domingues, Carolina Ortiz Rocha da Costa, Delmar Muniz Lourenço, Sı́lvia Condinho, R Miguel, Ana B. Barbosa, Custódia Gago, Nuno Torres Faria, Sérgio Paulino, Paulo Pereira,
... Dulce Lourenço3, Sílvia Condinho3, Rute Miguel1, Ana Barbosa1, Conceição Gago4, Natália Faria2, Sérgio Paulino2, Paulo Pereira2 1Faculdade de Ciências do Mar ...
Tópico(s): Marine Toxins and Detection Methods
2008 - Inter-Research Science Center | Aquatic Microbial Ecology
Produção Nacional
Revisado por pares
Mariana Conceição, Lucas Fernando Sérgio Gushiken, Jennyfer Andrea Aldana Mejía, Matheus Hikaru Tanimoto, Marcos Vital de Sá Ferreira, Andreia Cristina Miranda Alves, Marina Naomi Miyashita, Jairo Kenupp Bastos, Fernando Pereira Beserra, Cláudia Helena Pellizzon,
Skin wound healing is a complex process that requires the mutual work of cellular and molecular agents to promote tissue restoration. In order to improve such a process, especially in cases of impaired healing (e.g., diabetic ulcer, chronic wounds), there is a search for substances with healing properties and low toxicity: two features that some natural products—such as the bee product named propolis—exhibit. Propolis is a resinous substance obtained from plant resins and exudates with antioxidant, ...
Tópico(s): Essential Oils and Antimicrobial Activity
2022 - Multidisciplinary Digital Publishing Institute | Antioxidants
Produção Nacional
Fátima Conceição Rezende, Sérgio dos Reis Oliveira, Manoel Alves de Faria, Kelte Resende Arantes,
Irrigated coffee crop ( Coffea arabica L.) studies are quite common but almost no information is available on pruned irrigated coffee crops. This work reports studies carried out in Lavras, Minas Geais, Brazil to evaluate the total yield, volumetric yield, beans ripening uniformity, beans size and defects on several irrigation laminas. Coffee plants (cv. Topazio MG-1190) eavely pruned after 65 months from planting date were irrigated using self compensating drippers placed 0.40 m from each other. Planting ...
Tópico(s): Coffee research and impacts
2007 - UNIVERSIDADE FEDERAL DE LAVRAS | Coffee Science
Produção Nacional
Revisado por pares
Daniel Silva Moraes, Deborah de Farias Lelis, João Marcus Oliveira Andrade, Lara Meyer, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Lucyana Conceição Farias, Sérgio Henrique Sousa Santos,
Tópico(s): Adipose Tissue and Metabolism
2020 - Elsevier BV | Prostaglandins & Other Lipid Mediators
Produção Nacional
Revisado por pares
Eloá Mangabeira Santos, Lucyana Conceição Farias, Sérgio Henrique Sousa Santos, Alfredo Maurício Batista de Paula, Carla Silvana de Oliveira e Silva, André Luiz Sena Guimarães,
Understanding the biological processes underlying Pressure Ulcer (PU) is an important strategy to identify new molecular targets. Bioinformatics has emerged as an important screening tool for a broad range of diseases. This study aim of the current study is to investigate the protein-protein interaction in the PU context by bioinformatics. We performed a search in gene databases, and bioinformatics algorithms were used to generate molecular targets for PU based in silico investigation. Interactions ...
Tópico(s): Diabetic Foot Ulcer Assessment and Management
2017 - Elsevier BV | Journal of Tissue Viability
Produção Nacional
Revisado por pares
Edinildo de Oliveira Rodrigues, Izabel Rodrigues de Santana, Aimée Obolari Durço, Lino Sérgio Rocha Conceição, André Sales Barreto, Igor Alexandre Cortês de Menezes, Danilo Roman‐Campos, Márcio Roberto Viana dos Santos,
Abstract Sepsis is a host's dysregulated immune response to an infection associated with systemic inflammation and excessive oxidative stress, which can cause multiple organ failure and death. The literature suggests that flavonoids, a broad class of secondary plant metabolites, have numerous biological activities which can be valuable in the treatment of sepsis. This study aimed to review the effects of flavonoids on experimental sepsis, focusing mainly on survival rate, and also summarizing information ...
Tópico(s): Pharmacological Effects of Natural Compounds
2023 - Wiley | Phytotherapy Research
Produção Nacional
Revisado por pares
Mansueto Gomes Neto, André Rodrigues Durães, Lino Sérgio Rocha Conceição, Leonardo Roever, Cássio Magalhães Silva, Iura Gonzalez Nogueira Alves, Øyvind Ellingsen, Vitor Oliveira Carvalho,
The aim of this study was to investigate the effects of combined aerobic and resistance training on peak oxygen consumption (peak VO2), minute ventilation/carbon dioxide production (VE/VCO2 slope), muscle strength and health-related quality of life (HRQoL) in heart failure patients with reduced left ventricular ejection fraction (HFrEF).We searched Cochrane, Pubmed, and PEDro (from the earliest date available to September 2018) for RCTs that evaluated the effects of combined aerobic and resistance training ...
Tópico(s): Heart Failure Treatment and Management
2019 - Elsevier BV | International Journal of Cardiology
Produção Nacional
Revisado por pares
Mansueto Gomes Neto, André Rodrigues Durães, Lino Sérgio Rocha Conceição, Leonardo Roever, Tong Liu, Gary Tse, Giuseppe Biondi‐Zoccai, Ana Lúcia Barbosa Góes, Iura Gonzalez Nogueira Alves, Øyvind Ellingsen, Vitor Oliveira Carvalho,
Tópico(s): Cardiovascular Function and Risk Factors
2019 - Springer Science+Business Media | Current Atherosclerosis Reports
Produção Nacional
Revisado por pares
Mansueto Gomes Neto, André Rodrigues Durães, Lino Sérgio Rocha Conceição, Micheli Bernardone Saquetto, Øyvind Ellingsen, Vitor Oliveira Carvalho,
The aim of this study was to investigate the effects of high intensity interval training (HIIT) versus moderate intensity continuous training (MICT) in heart failure patients with reduced ejection fraction (HFrEF).Despite the well-known positive effects of exercise in heart failure patients, the best mode of exercise is still under discussion.We searched Pubmed/MEDLINE, Cochrane Central Register of Controlled Trials, PEDro data base, and SciELO (from the earliest date available to October 2017) for ...
Tópico(s): Cardiovascular Function and Risk Factors
2018 - Elsevier BV | International Journal of Cardiology
Produção Nacional
Revisado por pares
Lino Sérgio Rocha Conceição, Mansueto Gomes Neto, Mayra Alves Soares do Amaral, Paulo Ricardo Martins‐Filho, Vitor Oliveira Carvalho,
Dance therapy is a less conventional modality of physical activity in cardiovascular rehabilitation. We performed a systematic review and meta-analysis to investigate the effects of dance therapy in hypertensive patients.Pubmed, Scopus, LILACS, IBECS, MEDLINE and SciELO via Virtual Health Library (Bireme) (from the earliest data available to February 2016) for controlled trials that investigated the effects of dance therapy on exercise capacity, systolic (SBP) and diastolic (DBP) blood pressure in hypertensive ...
Tópico(s): Physical Education and Training Studies
2016 - Elsevier BV | International Journal of Cardiology
Produção Nacional
Revisado por pares
Lydiane Tavares Toscano, Renata Leite Tavares, Luciana Tavares Toscano, Cássia Surama Oliveira da Silva, Antônio Eduardo Monteiro de Almeida, A. C. T. Biasoto, Maria da Conceição Rodrigues Gonçalves, Alexandre Sérgio Silva,
Recent studies have indicated that certain food products have ergogenic potential similar to that of sports supplements. The present study aimed to investigate the potential ergogenic effect of integral purple grape juice on the performance of recreational runners. Twenty-eight volunteers of both sexes (age, 39.8 ± 8.5 years; peak oxygen consumption, 43.2 ± 8.5 mL/(kg·min)) were randomized into either a group that received grape juice (grape juice group (GJG), n = 15; 10 mL/(kg·min) for 28 days) or a group ...
Tópico(s): Cardiovascular and exercise physiology
2015 - NRC Research Press | Applied Physiology Nutrition and Metabolism
Produção Nacional
Revisado por pares
Sérgio Henrique Conceição, Gilson Barbosa Dourado, Ana Gabriela Moura Baqueiro, Simone Grohs Freire, Pauline das Chagas Brito,
O presente trabalho constitui-se, enquanto uma pesquisa qualitativa e quantitativa, que a partir do levantamento de literatura acerca do processo de disclosure, em responsabilidade social corporativa (RSC) em companhias brasileiras. Realizou levantamento dos relatórios disponibilizados pelas companhias listadas na BOVESPA (Bolsa de Valores do Estado de São Paulo) para um conjunto de 123 empresas, fundamentado pelo referencial da Teoria da Divulgação Voluntária e da Teoria da Legitimidade, aliado à ...
Tópico(s): Corporate Social Responsibility Reporting
2011 - UNIVERSIDADE FEDERAL DE SÃO CARLOS | Gestão & Produção
Produção Nacional
Revisado por pares
Silvia G. Conway, Laura Castro, Maria Cecília Lopes-Conceição, Helena Hachul, Sérgio Tufik,
Sleep architecture and polysomnographic findings show that the majority of sleepwalking episodes occur during slow-wave sleep (SWS).1–4 Although genetics play an important role in the manifestation of sleepwalking,5,6 recent studies have shown that parasomnias are also associated with other sleep or mental disorders3,7,10,11 and psychological factors.3,7,10–14 Sleepwalking prevalence rates are higher in childhood15 than in adulthood.10 Due to the risk of injuries3,4,10,16,17 beyond the presence of ...
Tópico(s): Obstructive Sleep Apnea Research
2011 - Elsevier BV | Clinics
Produção Nacional
Revisado por pares
Emilia do Socorro Conceição de Lima, Paulo Sérgio de Arruda Pinto, Jósé Lúcio dos Santos, Maria Cristina Dantas Vanetti, Paula Días Bevilacqua, Laerte Pereira de Almeida, Mayara Souza Pinto, Francesca Silva Dias,
O presente estudo foi realizado para avaliar a presença de Salmonella sp e o número de Staphylococcus aureus na superfície de carcaças suínas e caracterizar os perigos microbiológicos em diferentes etapas do abate e pontos críticos de controle (PCCs), através da quantificação de riscos (odds ratio). Um total de 120 esfregaços superficiais de carcaça suína foi coletado em um matadouro-frigorífico, após o escaldamento/depilação (ponto A), antes da evisceração (B), após evisceração e serragem da carcaça ( ...
Tópico(s): Meat and Animal Product Quality
2004 - Colégio Brasileiro de Patologia Animal (CBPA) | Pesquisa Veterinária Brasileira
Produção Nacional
Lino Sérgio Rocha Conceição, Caroline Oliveira Gois, Raiane Eunice Santos Fernandes, Paulo Ricardo Martins‐Filho, Mansueto Gomes Neto, Victor Ribeiro Neves, Vitor Oliveira Carvalho,
Heart transplantation (HTx) is the gold standard procedure for selected individuals with refractory heart failure. Highintensity interval training (HIIT) is safe and allows patients to exercise in high intensity for longer time when compared to moderateintensity continuous training (MICT). The primary aim of this study was to perform a systematic review and meta-analysis about the effect of HIIT compared to MICT on exercise capacity, peak heart rate, and heart rate reserve in HTx recipients. Secondarily, ...
Tópico(s): Heart Failure Treatment and Management
2020 - Brazilian Society of Cardiovascular Surgery | Brazilian Journal of Cardiovascular Surgery
Produção Nacional
Revisado por pares
Vitor Oliveira Carvalho, Lino Sérgio Rocha Conceição, Miburge Bolivar Gois,
current concepts about life, society, and the relationship with technology are being
Tópico(s): Empathy and Medical Education
2020 - Wiley | Journal of Cardiac Surgery
Produção Nacional
Revisado por pares
Alana Lalucha de Andrade Guimarães, Mansueto Gomes Neto, Lino Sérgio Rocha Conceição, Micheli Bernardone Saquetto, Caroline Oliveira Gois, Vitor Oliveira Carvalho,
Background. There is a growing use of water-based exercises in cardiac rehabilitation programs. However, there is little data concerning the effects of water-based exercise on the exercise capacity of coronary artery disease (CAD) patients. Objective. To perform a systematic review to investigate the effects of water-based exercise on peak oxygen consumption, exercise time, and muscle strength in patients with CAD. Methods. Five databases were searched to find randomized controlled trials that evaluated ...
Tópico(s): Heart Rate Variability and Autonomic Control
2023 - Wiley | Cardiovascular Therapeutics
Paula Laranjeira, Raquel Rodrigues, Tiago Carvalheiro, Conceição Constanço, Helena Vitória, Sergio Matarraz, Hélder Trindade, Alberto Órfão, Artur Paiva,
Erythroid dysplasia is a common feature of myelodysplastic syndromes (MDS). Currently available information about the immunophenotypic features of normal and dysplastic erythropoiesis is scarce and restricted to relatively few markers. Here we studied the expression of CD117, CD35 and CD44 throughout the normal (n = 16) and dysplastic (n = 48) bone marrow erythroid maturation. CD35 emerged as an early marker of CD34+ erythroid-committed precursors, which is expressed before CD105 and remains positive thereafter. ...
Tópico(s): Erythrocyte Function and Pathophysiology
2014 - Elsevier BV | Leukemia Research
Produção Nacional
Revisado por pares
Iara Clemente, Frederico Sobrinho da Silva, Lazaro Laut, Fabrizio Frontalini, Vitor Lima da Costa, Maria Antonieta da Conceição Rodrigues, Egberto Pereira, Sérgio Bergamaschi, João Graciano Mendonça Filho, Maria Virgínia Alves Martins,
Clemente, I.M.M.M.; da Silva, F.S.; Laut, L.L.M.; Frontalini, F.; da Costa, V.L.; da Conceição Rodrigues, M.A.; Pereira, E.; Bergamaschi, S.; Filho, J.G.M., and Martins, M.V.A., 2015. Biochemical composition and foraminiferal content of sediments for determining bottom sector environments in Guanabara Bay (Rio de Janeiro, Brazil).Three cities in Brazil—Rio de Janeiro, Niterói, and São Gonçalo—with an estimated total population of 11 million people, are located in the surroundings of Guanabara Bay ( ...
Tópico(s): Marine and coastal ecosystems
2014 - Coastal Education and Research Foundation | Journal of Coastal Research