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Artigo Brasil Produção Nacional Revisado por pares

Ricardo S. Santos, Suzana Mária Fleury Malheiros, Sérgio Cavalheiro, José Maria Parente de Oliveira,

Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. Malignant brain neoplasms are among the most devastating and incurable forms of cancer, and their treatment may be excessively complex and costly. Public health decision makers require significant amounts of analytical information to manage public treatment programs for these patients. Data mining, a technology that is used to produce analytically useful information, ...

Tópico(s): Advanced Graph Neural Networks

2012 - Elsevier BV | Computer Methods and Programs in Biomedicine

Artigo Acesso aberto Revisado por pares

Toni Machado, Tiago Malheiro, Sérgio Monteiro, Wolfram Erlhagen, Estela Bicho,

This paper shows how non-linear attractor dynamics can be used to control teams of two autonomous mobile robots that coordinate their motion in order to transport large payloads in unknown environments, which might change over time and may include narrow passages, corners and sharp U-turns. Each robot generates its collision-free motion online as the sensed information changes. The control architecture for each robot is formalized as a non-linear dynamical system, where by design attractor states, ...

Tópico(s): Distributed Control Multi-Agent Systems

2018 - Springer Science+Business Media | Autonomous Robots

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Maurício Andrade Azevedo, Guilherme Blattner Torres de Oliveira, Carlos Alberto Malheiros, Sérgio Roll,

ABSTRACT BACKGROUND: Regarding postoperative pain, it remains unclear whether non-fixation of the polypropylene prosthesis in transabdominal preperitoneal inguinal hernia repair produces the same outcomes as mesh fixation with glue or tackers. In addition, hernia recurrence is another aspect to be assessed in the comparison between non-fixation and mesh-fixation techniques (tackers and glue). AIMS: This study aimed to evaluate the incidence, quality of pain, and recurrence in patients undergoing ...

Tópico(s): Appendicitis Diagnosis and Management

2022 - Colégio Brasileiro de Cirurgia Digestiva | ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Lorena Favaro Pavon, Luciana Cavalheiro Marti, Tatiana Taís Sibov, Suzana Mária Fleury Malheiros, Reynaldo André Brandt, Sérgio Cavalheiro, Lionel Fernel Gamarra,

Glioblastomas are the most lethal primary brain tumor that frequently relapse or progress as focal masses after radiation, suggesting that a fraction of tumor cells are responsible for the tumor regrowth. The identification of a brain tumor cell subpopulation with potent tumorigenic activity supports the cancer stem cell hypothesis in solid tumors. The goal of this study is to determine a methodology for the establishment of primary human glioblastoma cell lines. Our aim is achieved by taking the ...

Tópico(s): 3D Printing in Biomedical Research

2014 - Frontiers Media | Frontiers in Neurology

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Lorena Favaro Pavon, David Capper, Tatiana Taís Sibov, Sílvia Regina Caminada de Toledo, Ulrich-W. Thomale, Jean Gabriel de Souza, Francisco Romero Cabral, Carolina Maria Berra, Marcos Devanir Silva da Costa, Jardel Mendonça Nicácio, Patrícia Alessandra Dastoli, Daniela Mara de Oliveira, Suzana Mária Fleury Malheiros, Edgar Ferreira da Cruz, Jackeline Moraes Malheiros, Sérgio Mascarenhas de Oliveira, Nasjla Saba Silva, Antônio Sérgio Petrilli, Andréa Cappellano, Milena Karina Coló Brunialti, Reinaldo Salomão, Manoel Antônio de Paiva Neto, Ana Marisa Chudzinski‐Tavassi, Sérgio Cavalheiro,

EPNs comprise a heterogeneous group of neuroepithelial tumors, accounting for about 10% of all intracranial tumors in children and up to 30% of brain tumors in those younger than 3 years. Actually, the pattern therapy for low-grade EPNs includes complete surgical resection followed by radiation therapy. Total surgical excision is often not possible due to tumor location. The aim of this study was to evaluate, for the first time, the anti-tumor activity of Amblyomin-X in 4 primary cultures derived ...

Tópico(s): Ubiquitin and proteasome pathways

2019 - Nature Portfolio | Scientific Reports

Artigo Brasil Produção Nacional Revisado por pares

Thaise Boeing, Priscila de Souza, Tiago José Bonomini, Luísa Nathália Bolda Mariano, Líncon Bordignon Somensi, Ruth Meri Lucinda, Ângela Malheiros, Luísa Mota da Silva, Sérgio Faloni de Andrade,

This study aimed to investigate the potential effect of plumieride, an iridoid glycoside isolated from Alamanda cathartica L. flowers, against dextran sulfate sodium (DSS)-induced colitis in mice. Colitis was induced in female swiss mice by adding DSS 3% to the drinking water. The animals were treated with vehicle (water), 5-aminosalicylic acid (100?mg/kg) or plumieride (10, 30 and 100?mg/kg) once a day, during 7 days. The body weight progression and the disease activity index was evaluated daily. On ...

Tópico(s): Microscopic Colitis

2018 - Elsevier BV | Biomedicine & Pharmacotherapy

Artigo Brasil Produção Nacional Revisado por pares

Osvaldo Ribeiro Saldanha, Rodrigo Federico, P. Daher, Andrey A. Malheiros, Paulo R. G. Carneiro, Sérgio F. D. Azevedo, Osvaldo R. Saldanha Filho, Cristianna Bonetto Saldanha,

Background: Abdominoplasty is one of the most common aesthetic operations. Wide bibliographic research has revealed that there is a safe method whereby two techniques—liposuction and abdominoplasty—can be associated in the same procedure. The authors present a new abdominoplasty technique combining a selective undermining with complete abdominal liposuction. Methods: The authors standardized steps with which to perform a safe association of traditional abdominoplasty with liposuction of the entire ...

Tópico(s): Lymphatic System and Diseases

2009 - Lippincott Williams & Wilkins | Plastic & Reconstructive Surgery

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Sandra M. B. P. Moreira, André Luís Lacerda Bachi, Elias I. Jirjos, Carlos Alberto Malheiros, Sérgio Vencio, Vera Lúcia dos Santos Alves, Alan Robson Trigueiro de Sousa, Lucenda A. Felipe, Eduardo Araújo Perez, Maria Eduarda Moreira Lino, Shayra Kellen Arantes Souza, Juliana de Melo Batista dos Santos, Miriã Cândida Oliveira, Adriano Luís Fonseca, Carlos H. M. Silva, Rodolfo P. Vieira, Giuseppe Insalaco, Wilson Rodrigues de Freitas, Luís Vicente Franco de Oliveira,

Obesity is a troubling public health problem as it increases risks of sleep disorders, respiratory complications, systemic arterial hypertension, cardiovascular diseases, type 2 diabetes mellitus, and metabolic syndrome (MetS). As a measure to counteract comorbidities associated with severe obesity, bariatric surgery stands out. This study aimed to investigate the adiponectin/leptin ratio in women with severe obesity with and without MetS who had undergone Roux-en-Y gastric bypass (RYGB) and to characterize ...

Tópico(s): Adipokines, Inflammation, and Metabolic Diseases

2023 - Multidisciplinary Digital Publishing Institute | Nutrients

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Lorena Favaro Pavon, Tatiana Taís Sibov, Andréa Vieira de Souza, Edgar Ferreira da Cruz, Suzana Mária Fleury Malheiros, Francisco Romero Cabral, Jean Gabriel de Souza, Pamela Boufleur, Daniela Mara de Oliveira, Sílvia Regina Caminada de Toledo, Luciana Cavalheiro Marti, Jackeline Moraes Malheiros, Fernando Fernandes Paiva, Alberto Tannús, Sérgio Mascarenhas de Oliveira, Ana Marisa Chudzinski‐Tavassi, Manoel Antônio de Paiva Neto, Sérgio Cavalheiro,

Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these cells a potential vehicle for delivery of therapeutic agents to disseminated glioblastoma (GBM) cells. However, the potential contribution of MSCs to tumor progression is a matter of concern. It has been suggested that CD133+ GBM stem cells secrete a variety of chemokines, including monocytes chemoattractant protein-1 (MCP-1/CCL2) and stromal cell-derived factor-1(SDF-1/CXCL12), ...

Tópico(s): Glioma Diagnosis and Treatment

2018 - BioMed Central | Stem Cell Research & Therapy

Artigo Revisado por pares

João Galvão, Sérgio Leitão, Salvador Malheiro Silva, T. Gaio,

Tópico(s): Energy and Environment Impacts

2010 - Elsevier BV | Fuel Processing Technology

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Luciano Neder, Suely Kazue Nagahashi Marie, Carlos Gilberto Carlotti, Alberto Alain Gabbai, Sérgio Rosemberg, Suzana MF Malheiros, Rodrigo Proto Siqueira, Sueli Mieko Oba‐Shinjo, Miyuki Uno, Paulo Henrique Pires de Aguiar, Flávio Key Miura, Roger Chammas, Benedicto Oscar Colli, Wilson A. Silva, Marco A. Zago,

The distinction of astrocytomas and oligodendrogliomas, mainly pilocytic astrocytomas (PILOs) from infiltrating astrocytomas and oligodendrogliomas (ODs), and high-grade oligodendrogliomas from glioblastomas (GBMs), poses a serious clinical problem. There is no useful immunohistochemical (IHC) marker to differentiate these gliomas, and sometimes the differential diagnosis between them is arbitrary. We identified galectin-3 (Gal-3) as a possible tool to differentiate them based on gene expression profiles ...

Tópico(s): Peptidase Inhibition and Analysis

2004 - Wiley | Brain Pathology

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Simone Cristina Olenscki Gilli, I.F.S.F. Boin, Luiz Sérgio Leonardi, Ângela Cristina Malheiros Luzo, Fernando Ferreira Costa, Sara T.O. Saad,

Background. Patients presenting sickle cell disease may develop different types of hepatic complications. Intrahepatic cholestasis is a potentially fatal complication of the disease, and sometimes the only possible solution is transplantation. Postoperative transfusion management has not yet been well established. In this report, we describe the transfusional program of a patient presenting sickle cell disease and intrahepatic cholestasis who underwent liver transplantation 2 years ago. Methods. ...

Tópico(s): Iron Metabolism and Disorders

2002 - Wolters Kluwer | Transplantation

Artigo Brasil Produção Nacional Revisado por pares

Jackeline Moraes Malheiros, Marcelo M.S. Lima, Renata Della Torre Avanzi, Sérgio Gomes da Silva, Deborah Suchecki, Ruth Guinsburg, Luciene Covolan,

Neonatal noxious stimulation has been proposed to model pain triggered by diagnostic/therapeutic invasive procedures in premature infants. Previous studies have shown that hippocampal neurogenesis rate and the behavioral repertoire of adult rats may be altered by neonatal noxious stimuli. The purpose of this study was to evaluate whether noxious stimulation during neonatal period alters the nociceptive response and dentate gyrus neurogenesis when compared to rats subjected to a single noxious stimulus ...

Tópico(s): Infant Development and Preterm Care

2013 - Wiley | Hippocampus

Artigo Acesso aberto Revisado por pares

Carina Ruano, Rui Malheiro, João Francisco Coelho de Oliveira, Sofia Pinheiro, Luís Sérgio Vieira, Maria Francisca Moraes‐Fontes,

To assess the prevalence and severity of ultrasonographic abnormalities of the hand and wrist of asymptomatic patients with systemic lupus erythematosus (SLE) and compare these findings with those from patients with SLE with musculoskeletal signs or symptoms and healthy controls.We conducted a prospective cross-sectional study that evaluated bilaterally, with grey-scale and power Doppler (PD) ultrasound (US), the dorsal hand (2nd to 5th metacarpophalangeal and 2nd to 5th proximal interphalangeal joints) ...

Tópico(s): Viral Infections and Immunology Research

2017 - BMJ | Lupus Science & Medicine

Artigo Acesso aberto Revisado por pares

Anabela Carvalho Alves, Francisco Moreira, M. Alice Carvalho, Sérgio Oliveira, Teresa Malheiro, Irene Brito, Celina P. Leão, Senhorinha Teixeira,

Paper aims This paper presents teachers and students perspectives of integration Science, Technology, Engineering and Mathematics (STEM) courses contents into the first year of Industrial Engineering and Management (IEM) program through Project-Based Learning (PBL). Originality These perspectives provide strategies that IEM teachers could use to challenge students to apply STEM contents to design a product and its production system by developing a semester interdisciplinary project. Research method ...

Tópico(s): Problem and Project Based Learning

2019 - Associação Brasileira de Engenharia de Produção | Production

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Tatiana Taís Sibov, Lorena Favaro Pavon, Francisco Romero Cabral, Ivone Farias Cunha, Daniela Mara de Oliveira, Jean Gabriel de Souza, Luciana Cavalheiro Marti, Edgar Ferreira da Cruz, Jackeline Moraes Malheiros, Fernando Fernandes Paiva, Alberto Tannús, Sérgio Mascarenhas de Oliveira, Marcos Devanir Silva da Costa, Patrícia Alessandra Dastoli, J Mendonca, Sílvia Regina Caminada de Toledo, Suzana M. Fleury Malheiros, Manoel Antônio de Paiva Neto, Nelma Bastos Bezerra Rego, Antônio Fernandes Moron, Sérgio Cavalheiro,

Amniotic fluid has been investigated as new cell source for stem cells in the development of future cell-based transplantation. This study reports isolation of viable human amniotic fluid-derived stem cells, labeled with multimodal iron oxide nanoparticles, and its effect on focal cerebral ischemia–reperfusion injury in Wistar rats. Middle cerebral artery occlusion of 60 min followed by reperfusion for 1 h, 6 h, and 24 h was employed in the present study to produce ischemia and reperfusion-induced ...

Tópico(s): Neurogenesis and neuroplasticity mechanisms

2019 - SAGE Publishing | Cell Transplantation

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Christiano Machado, Denise Maria Avancini Costa Malheiros, Ari Adamy, Luiz Sérgio Santos, Agenor Ferreira da Silva Filho, William Carlos Nahas, Francine Brambate Carvalhinho Lemos,

OBJECTIVE:Prolonged warm ischemia time and increased intra-abdominal pressure caused by pneumoperitoneum during a laparoscopic donor nephrectomy could enhance renal ischemia reperfusion injury.For this reason, laparoscopic donor nephrectomy may be associated with a slower graft function recovery.However, an adequate protective response may balance the ischemia reperfusion damage.This study investigated whether laparoscopic donor nephrectomy modified the protective response of renal tissue during ...

Tópico(s): Eicosanoids and Hypertension Pharmacology

2013 - Elsevier BV | Clinics

Revisão Brasil Produção Nacional

Eduardo Augusto Iunes, João Norberto Stávale, Rita de Cássia Caldas Pessoa, Ricardo Ansai, Franz Jooji Onishi, Manoel Antônio de Paiva Neto, Antônio de Pádua Furquim Bonatelli, Sérgio Cavalheiro, Suzana Mária Fleury Malheiros,

In this paper, the authors present the case of a patient with multifocal intradural extramedullary ependymoma, and they review 18 previously reported cases. A 32-year-old man presented to the authors' institution with a 1-month history of partial medullary syndrome. Magnetic resonance imaging of the neuraxis revealed multifocal intradural extramedullary lesions at the bulbomedullary junction and C2-3, T5-11, L-2, L-4, L-5, and sacrum. Histological examination revealed a WHO Grade II ependymoma. ...

Tópico(s): Intraoperative Neuromonitoring and Anesthetic Effects

2010 - | Journal of Neurosurgery Spine

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Pedro Henrique de Freitas Amaral, LUCA GIOVANNI ANTONIO PIVETTA, Eduardo Rullo Maranhão Dias, João Paulo Venancio de Carvalho, Marcelo Lopes Furtado, Carlos Alberto Malheiros, Sérgio Roll,

to describe the use of the robotic platform in inguinal hernia recurrence after a previous laparoscopic repair.patients with recurrent inguinal hernias following a laparoscopic repair who have undergone robotic transabdominal preperitoneal between December 2015 through September 2020 were identified in a prospectively maintained database. Outcomes of interest included demographics, hernia characteristics, operative details and rates of 30-day surgical site occurrence, surgical site occurrences requiring ...

Tópico(s): Abdominal Surgery and Complications

2022 - Brazilian College of Surgeons | Revista do Colégio Brasileiro de Cirurgiões

Carta Brasil Produção Nacional Revisado por pares

Paulo Sérgio Castilho Preté, Sônia Valéria Pinheiro Malheiros, Nilce Correa Meirelles, Eneida de Paula,

We report here a quantitative analysis of the interaction of the non-ionic surfactant Triton X-100 with human erythrocyte membranes. By applying a classical treatment for the interpretation of the action of surface active compounds to the hemolytic curves, we could calculate parameters such as Re—the effective surfactant/lipid molar ratio for erythrocyte membrane saturation (Resat) and total lysis (Resol)—and Kb, the binding constant of Triton X-100 to human erythrocyte membranes. The Kb (5900 M−1) ...

Tópico(s): Protein Interaction Studies and Fluorescence Analysis

2002 - Elsevier BV | Biophysical Chemistry

Artigo Acesso aberto Brasil Produção Nacional

Lorena Favaro Pavon, Tatiana Taís Sibov, Daniela Mara de Oliveira, Luciana Cavalheiro Marti, Francisco Romero Cabral, Jean Gabriel de Souza, Pamela Boufleur, Suzana Mária Fleury Malheiros, Manuel Antônio de Paiva Neto, Edgar Ferreira da Cruz, Ana Marisa Chudzinski‐Tavassi, Sérgio Cavalheiro,

Glioblastoma is composed of dividing tumor cells, stromal cells and tumor initiating CD133+ cells. Recent reports have discussed the origin of the glioblastoma CD133+ cells and their function in the tumor microenvironment. The present work sought to investigate the multipotent and mesenchymal properties of primary highly purified human CD133+ glioblastoma-initiating cells. To accomplish this aim, we used the following approaches: i) generation of tumor subspheres of CD133+ selected cells from primary ...

Tópico(s): MicroRNA in disease regulation

2016 - Impact Journals LLC | Oncotarget

Artigo Brasil Produção Nacional Revisado por pares

Sergio Celaschi, Gilliard N. Malheiros‐Silveira,

A family of narrowband spectral filters based on biconic fiber tapers is investigated. These filters were made of highly-depressed-cladding single-mode fibers by a heat-and-pulling process, and using a cylindrical-tube graphite heater. The evolution of the taper profiles during the pulling of different elongations was modeled by a coupled system of partial differential equations governing the mass and axial momentum conservation. The optical responses were modeled by using the mode coupling theory. ...

Tópico(s): Optical Network Technologies

2017 - Institute of Electrical and Electronics Engineers | Journal of Lightwave Technology

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Miyuki Uno, Sueli Mieko Oba‐Shinjo, Roseli da Silva, Flávio Key Miura, Carlos Clara, J.R.W. Almeida, Suzana Mária Fleury Malheiros, A Bianco, Reynaldo André Brandt, Guilherme Carvalhal Ribas, Halim Feres, Carlos Dzik, Sérgio Rosemberg, João Norberto Stávale, Manoel Jacobsen Teixeira, Suely Kazue Nagahashi Marie,

GBM may manifest rapidly de novo(primary GBM), or may develop slowly from grade II orgrade III astrocytomas (secondary GBM), suggesting thatthey are distinct disease entities that evolve throughdifferent genetic pathways.In recent genome-wide analyses, high rates of sponta-neous mutations in the gene encoding cytosolic NADP-dependent isocitrate dehydrogenase 1 (IDH1) have beenreported in diffuse gliomas including WHO grades II andIII astroglial and oligodendroglial lineages.

Tópico(s): Pancreatic and Hepatic Oncology Research

2011 - Elsevier BV | Clinics

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Olga Cristina de Mello Malheiro, Camila Tateishi Giacomini, Luís Antônio Justulin, Flávia Karina Delella, Maeli Dal‐Pai‐Silva, Sérgio Luís Felisbino,

Abstract Increased activity of matrix metalloproteinases (MMPs) ‐2 and ‐9 was found in calcaneal tendon after physical training. However, little attention has been given to the distinct biomechanical and tissue structure of the calcaneal tendon's proximal and distal regions. Herein, we evaluated the effect of two types of physical activities on tendon morphology and matrix metalloproteinase activities in the proximal and distal regions of rat calcaneal tendon, separately. Adult male Wistar rats from ...

Tópico(s): Foot and Ankle Surgery

2009 - Wiley | The Anatomical Record

Artigo Brasil Produção Nacional Revisado por pares

Paulo Sérgio Castilho Preté, Karolyna Gomes, Sônia Valéria Pinheiro Malheiros, Nilce Correa Meirelles, Eneida de Paula,

In the present study, we investigated the interaction of the non-ionic surfactants polyoxyethylene alkyl ethers (CnEm) with erythrocyte membranes. For this purpose we have performed hemolytic assays under isosmotic conditions with five surfactants in the 8 polyoxyethylene ether series. By applying to the hemolytic curves a quantitative treatment developed for the study of surface-active compounds on biomembranes, we could calculate the surfactant/lipid molar ratios for the onset of hemolysis (Resat) ...

Tópico(s): Lipid Membrane Structure and Behavior

2002 - Elsevier BV | Biophysical Chemistry

Artigo Acesso aberto Brasil Produção Nacional

Leonardo José Bernardes Albertoni, Felipe C. Schumacher, Matheus Henrique Araújo Ventura, Carlos Eduardo da Silveira Franciozi, Pedro Debieux, Marcelo Seiji Kubota, Geraldo Sérgio de Mello Granata, Marcus Vinícius Malheiros Luzo, Antônio Altenor Bessa de Queiroz, Mário Carneiro Filho,

The objective of this study is to evaluate the results and effectiveness of the technique of meniscal repair type all-inside using Fast-Fix device.A retrospective cohort study evaluating 22 patients with meniscal surgery between January 2004 and December 2010 underwent meniscal repair technique for all-inside with the Fast-Fix device with or without ACL reconstruction. Function and quality of life outcomes were chosen by the IKDC and Lysholm score, before and postoperatively, and reoperation rates, ...

Tópico(s): Sports injuries and prevention

2013 - Brazilian Society of Orthopedics and Traumatology | Revista Brasileira de Ortopedia (English Edition)

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

G. A. Carvalho, P. H. R. S. Moraes, Sérgio Ivan dos Santos, Berenice Santos Gonçalves, M. Malheiro,

In this work we analyze hydrostatic equilibrium configurations of neutron stars in a non-minimal geometry-matter coupling (GMC) theory of gravity. We begin with the derivation of the hydrostatic equilibrium equations for the $f(R,L) $ gravity theory, where $R$ and $L$ are the Ricci scalar and Lagrangian of matter, respectively. We assume $f(R,L)=R/2+[1+\sigma R]L$, with $\sigma$ constant. To describe matter inside neutron stars we assume the polytropic equation of state $p=K \rho^{\gamma}$, with $K$ and $\gamma = ...

Tópico(s): Black Holes and Theoretical Physics

2020 - Springer Science+Business Media | The European Physical Journal C