Produção Nacional
Revisado por pares
Maria S. Pombo‐de‐Oliveira, Sérgio Koifman,
Abstract Infant acute leukemia (IAL) has a unique profile characterized by the high incidence of translocations involving the MLL gene located at the 11q23 region. To test the potential role of intrauterine and perinatal factors linked to the risk of IAL development, a hospital-based case-control study was conducted in different cities of Brazil. A total of 202 children (ages 0-21 months) with newly diagnosed IAL was enrolled (1999-2005), and 440 age-matched controls were selected from the same hospitals ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2006 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention
Produção Nacional
Revisado por pares
Arnaldo Cézar Couto, Jeniffer Dantas Ferreira, Ana Cristina Simões Rosa, Maria S. Pombo‐de‐Oliveira, Sérgio Koifman,
To investigate the association between maternal exposure to hair dyes and hair straightening cosmetics (HDSC) during pregnancy and leukemia at an early age (<2yr., EAL).A multicenter hospital-based case-control study was carried out in 13 states in Brazil between 1999 and 2007. Mothers of 176 ALL (acute lymphocytic leukemia) and 55 AML (acute myeloid leukemia) cases and 419 controls were enrolled and interviewed. Data on maternal exposure to HDSC occurring 3months before pregnancy, during pregnancy and ...
Tópico(s): Cancer Risks and Factors
2013 - Elsevier BV | Chemico-Biological Interactions
Produção Nacional
Revisado por pares
Maria S. Pombo‐de‐Oliveira, Sérgio Koifman, Gisele M. Vasconcelos, Mariana Emerenciano, Cristiane de Oliveira Novaes,
In this concise report, we describe the history and evolution of childhood acute leukemia studies in Brazil, and the application if key biomarkers for clinical trials and epidemiological studies over the past 8 years. Highlights of each ongoing study are summarized. A Brazilian network integrating hospitals and scientific institutions from all country regions has been established. This organization is made possible through informatics and computer networking, and the standardization of pathological ...
Tópico(s): Retinoids in leukemia and cellular processes
2008 - Elsevier BV | Blood Cells Molecules and Diseases
Produção Nacional
Revisado por pares
Arnaldo Cézar Couto, Jeniffer Dantas Ferreira, Rosalina Jorge Koifman, Gina Torres Rego Monteiro, Maria do Socorro Pombo–de–Oliveira, Sérgio Koifman,
To analyze trends in childhood leukemia mortality in the state of Rio de Janeiro, Brazil, between 1980 and 2006.Gender-stratified leukemia mortality data for children aged < 15 years from 1980 to 2006 were retrieved from the Brazilian Mortality Information System for the state of Rio de Janeiro. Data were stratified by place of death (city of Rio de Janeiro proper, the state capital; Rio de Janeiro Metropolitan Region, excluding the capital; and rest of the state). Leukemia deaths were defined according ...
Tópico(s): Acute Myeloid Leukemia Research
2010 - Elsevier BV | Jornal de Pediatria
Produção Nacional
Revisado por pares
Jeniffer Dantas Ferreira, Arnaldo Cézar Couto, Maria S. Pombo‐de‐Oliveira, Sérgio Koifman,
An association between pesticide exposure and cancer has been suggested. Infant leukemia is a rare neoplasm and its association with maternal pesticide exposure has been poorly explored.We investigated the association between pesticide exposure during pregnancy and leukemia in children < 2 years of age.A hospital-based case-control study was carried out in 13 Brazilian states during 1999-2007. Mothers of 252 cases and those of 423 controls were interviewed. Information on pesticide exposures 3 months ...
Tópico(s): Cancer Risks and Factors
2012 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Produção Nacional
Revisado por pares
Arnaldo Cézar Couto, Jeniffer Dantas Ferreira, Maria S. Pombo‐de‐Oliveira, Sérgio Koifman,
Childhood leukemia etiology, and mainly the interactions of genetic and environmental risk factors, remains largely unexplored. This national hospital-based case–control study was carried out in Brazil among children aged 0–23 months who were recruited at cancer and general hospitals in 13 states. Maternal medicine intake during pregnancy, including analgesic intake, was assessed by face-to-face interviews with the mothers of 231 leukemia patients and 411 controls. Unconditional logistic regression ...
Tópico(s): Acute Lymphoblastic Leukemia research
2014 - Lippincott Williams & Wilkins | European Journal of Cancer Prevention
Produção Nacional
Revisado por pares
Lúcia Gomes Rodrigues, Nina Cid Loureiro Pombo, Sérgio Koifman,
OBJETIVO: Descrever a prevalência de síndrome metabólica em crianças e adolescentes com sobrepeso ou obesidade bem como os critérios utilizados em sua classificação. FONTES DOS DADOS: Revisão sistemática realizada por meio de busca eletrônica nas bases de dados Pubmed e na Biblioteca Virtual em Saúde. Os critérios de inclusão ado-tados foram apresentar dados de prevalência de síndrome metabólica em crianças e adolescentes com sobrepeso e obesidade, sendo publicados em português, inglês, espanhol ...
Tópico(s): Birth, Development, and Health
2011 - Elsevier BV | Revista Paulista de Pediatria
Almudena Val‐Blasco, Patricia Prieto, Rafael I. Jaén, Marta Gil-Fernández, Marta Pajares, Nieves Doménech, Verónica Terrón, María Tamayo, Inmaculada Jorge, Jesús Vázquez, Andrea Bueno-Sen, María Teresa Vallejo‐Cremades, Jorge Pombo-Otero, Sergio Sánchez‐García, Gema Ruiz‐Hurtado, Ana M. Gómez, Carlos Zaragoza, María G. Crespo‐Leiro, Eduardo López‐Collazo, Antonio Cuadrado, Carmen Delgado, Lisardo Boscá, María Fernández‐Velasco,
Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage associated with myocarditis progression. The cardioprotective role of BML-111 is mainly caused by the prevention of increased oxidative stress and nuclear factor erythroid-derived 2-like 2 (NRF2) down-regulation induced by myocarditis. At the molecular level, BML-111 activates NRF2 signaling, ...
Tópico(s): Galectins and Cancer Biology
2022 - Elsevier BV | JACC Basic to Translational Science
Vera B. Raposo, Carlos S. Melo, Luís Silva, Maria A. Ventura, Rita Câmara, Joana Pombo, Markes E. Johnson, Sérgio P. Ávila,
The increasing interest in geotourism has prompted the need for quantitative assessments of geosites as a fundamental step in the application of geoconservation strategies, in order to assure sustainable planning, management and use of natural resources. The improvement of methodologies used to evaluate geosites dictates the revision of previous assessments on a regular basis. Santa Maria Island in the Azores Archipelago is renowned for its palaeontological heritage. Herein, we present the results ...
Tópico(s): Paleontology and Stratigraphy of Fossils
2018 - Multidisciplinary Digital Publishing Institute | Sustainability
Lara Baptista, António M. Santos, Carlos S. Melo, Ana Cristina Rebelo, Patrícia Madeira, Ricardo Cordeiro, Andrea Z. Botelho, Ana Hipólito, Joana Pombo, Antje H L Voelker, Sérgio P. Ávila,
Tópico(s): Marine Ecology and Invasive Species
2021 - Springer Science+Business Media | Marine Biology
Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A. Gorski, Stein Aerts, Ido Amit, Michela G. Bertero, Christoph Bock, Annelien L. Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M. Fernández, Marek Figlerowicz, Susan M. Gasser, Norbert Hübner, Jørgen Kjems, Juergen A. Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean‐Christophe Marine, John C. Marioni, Marc A. Martí‐Renom, Mihai G. Netea, Dörthe Nickel, Marcelo Nöllmann, Halina R. Novak, Helen Parkinson, Stefano Piccolo, Inês Pinheiro, Ana Pombo, Christian Popp, Wolf Reik, Sergio Román-Román, Philip Rosenstiel, Joachim L. Schultze, Oliver Stegle, Amos Tanay, Giuseppe Testa, Dimitris Thanos, Fabian J. Theis, Maria‐Elena Torres‐Padilla, Alfonso Valencia, Céline Vallot, Alexander van Oudenaarden, Marie Vidal, Thierry Voet, Lavinia Albéri, Stephanie Alexander, Theodore Alexandrov, Ernest Arenas, Claudia Bagni, Robert Balderas, Andrea Bandelli, Burkhard Becher, Matthias Becker, Niko Beerenwinkel, Monsef Benkirame, Marc Beyer, Wendy A. Bickmore, Erik E. A. L. Biessen, Niklas Blomberg, Ingmar Blümcke, Bernd Bodenmiller, Barbara Borroni, Dimitrios T. Boumpas, Thomas Bourgeron, Sarion R. Bowers, Dries Braeken, Cath Brooksbank, Nils Brose, Hilgo Bruining, Jo Bury, Nicolò Caporale, Giorgio Cattoretti, Nadia Chabane, Hervé Chneiweiss, Stuart A. Cook, Paolo Curatolo, Marien I. de Jonge, Bart De Strooper, Bart De Strooper, Peter de Witte, Stefanie Dimmeler, Bogdan Draganski, Anna Drews, Costică Dumbravă, Stefan Engelhardt, Thomas Gasser, Evangelos J. Giamarellos-Bourboulis, Caroline Graff, Dominic Grün, Marta Gut, Oskar Hansson, David C. Henshall, Anna Herland, Peter Heutink, Stéphane Heymans, Holger Heyn, Meritxell Huch, Inge Huitinga, Paulina Jackowiak, Karin Jongsma, Laurent Journot, Jan Philipp Junker, Shauna Katz, Jeanne Kehren, Stefan Kempa, Paulus Kirchhof, Christine Klein, Natalia Koralewska, Jan O. Korbel, Malte Kühnemund, Angus I. Lamond, Elsa Lauwers, Isabelle Le Ber, Ville Leinonen, Alejandro Tobon, Emma Lundberg, Astrid Lunkes, Henrike Maatz, Matthias Mann, Luca Marelli, Vera Matser, Paul M. Matthews, Fatima Mechta‐Grigoriou, Radhika Menon, A. Nielsen, Massimiliano Pagani, R. Jeroen Pasterkamp, Asla Pitkänen, Valentin Popescu, Cyril Pottier, Alain Puisieux, Rosa Rademakers, Dory Reiling, Orly Reiner, Daniel Remondini, Craig Ritchie, Jonathan D. Rohrer, Antoine-Emmanuel Saliba, Raquel Sánchez‐Valle, Amedeo Santosuosso, Arnold Sauter, Richard A. Scheltema, Philip Scheltens, Herbert B. Schiller, Anja Schneider, Philip Seibler, Kelly Sheehan‐Rooney, David J. Shields, Kristel Sleegers, August B. Smit, Kenneth G. C. Smith, Ilse Smolders, Matthis Synofzik, Wai Long Tam, Sarah A. Teichmann, Maria Thom, Margherita Y. Turco, Heleen M.M. van Beusekom, Rik Vandenberghe, Silvie Van den Hoecke, Ibo van de Poel, André van der Ven, Julie van der Zee, Jan van Lunzen, Geert Van Minnebruggen, Alexander van Oudenaarden, Wim Van Paesschen, John van Swieten, Remko van Vught, Matthijs Verhage, Patrik Verstreken, Carlo Emanuele Villa, Jörg Vogel, Christof von Kalle, Jörn Walter, Sarah Weckhuysen, Wilko Weichert, Louisa E. Wood, Anette‐Gabriele Ziegler, Frauke Zipp,
Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and ...
Tópico(s): Cancer Genomics and Diagnostics
2020 - Nature Portfolio | Nature
Carla Vázquez‐González, Laura Pombo‐Salinas, Lucía Martín‐Cacheda, Sergio Rasmann, Gregory Röder, Luis Abdala‐Roberts, Kailen A. Mooney, Xoaquín Moreira,
Abstract Airborne plant communication is a widespread phenomenon in which volatile organic compounds (VOCs) from damaged plants boost herbivore resistance in neighbouring, undamaged plants. Although this form of plant signalling has been reported in more than 30 plant species, there is still a considerable knowledge gap on how abiotic factors (e.g. water availability) alter its outcomes. We performed a greenhouse experiment to test for communication between potato plants Solanum tuberosum in response ...
Tópico(s): Plant Parasitism and Resistance
2022 - Wiley | Functional Ecology
Produção Nacional
Carolina Riscado Pombo, Sérgio Borges Mano, Valéria Moura de Oliveira, José Carlos Albuquerque do Prado Carvalho, Maria Carmela Kasnowski, Edivaldo Sampaio,
Este estudo objetivou avaliar possíveis alterações nos fatores de qualidade interna de ovos inteiros, submetidos ao tratamento térmico em banho-
Tópico(s): Infant Nutrition and Health
2006 - | Revista Brasileira de Ciência Veterinária
Produção Nacional
Revisado por pares
Marcela Braga Mansur, Mariana Emerenciano, Lilian Brewer, Mariana Oliveira Santana, Núbia Mendonça, Luiz Cláudio Santos Thuler, Sérgio Koifman, Maria S. Pombo‐de‐Oliveira,
SIL-TAL1 fusion gene and the ectopic expression of HOX11L2 are common molecular abnormalities in T-cell acute lymphoblastic leukemia (T-ALL). To verify their influence on outcome, we analyzed a Brazilian pediatric T-ALL series of cases. One hundred and ninety two children, age ranged 0–21 years old, were consecutively diagnosed and treated. Reverse transcriptase-polymerase chain reaction (RT-PCR) technique was used to identify the molecular alterations. Kaplan–Meyer method was applied to estimate ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2009 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Produção Nacional
Revisado por pares
Sérgio Koifman, Maria S. Pombo‐de‐Oliveira,
In this paper, we compared the birth weight distribution among 201 infant leukaemia (IL) cases with that of 440 noncancer controls enrolled in Brazil in 1999-2005. Compared with the general population and the stratum 2500-2999 g as reference, IL cases weighing 3000-3999 g presented an odds ratio (OR) of 1.68 (95% CI: 1.03-2.76), and those of 4000 g or more, an OR of 2.28 (95% CI: 1.08-4.75), P trend<0.01. Using hospital-based controls, the OR for 4000 g or more, compared to 2500-2999 g, was 1.30 (95% ...
Tópico(s): Acute Lymphoblastic Leukemia research
2008 - Springer Nature | British Journal of Cancer
Produção Nacional
Revisado por pares
Crisiane Wais Zanrosso, Mariana Emerenciano, Bruno Alves de Aguiar Gonçalves, Alessandra Faro, Sérgio Koifman, Maria S. Pombo‐de‐Oliveira,
Abstract Background: Maternal exposure to dipyrone during pregnancy has been associated with risk of infant leukemia (IL). N-Acetyltransferase 2 (NAT2) enzyme acetylates dipyrone, resulting in a detoxified metabolite. We performed genotyping to identify the distribution of NAT2 polymorphisms in duo samples from mothers and children previously investigated in a case-controlled study of IL. Methods: Samples from 132 IL, 131 age-matched controls, mothers of cases (n = 86), and mothers of controls (n = 36) ...
Tópico(s): Epigenetics and DNA Methylation
2010 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention
Produção Nacional
Revisado por pares
Mariana Emerenciano, Sérgio Koifman, Maria S. Pombo‐de‐Oliveira,
Acute leukemia in early childhood is biologically and clinically distinct. The particular characteristics of this malignancy diagnosed during the first months of life have provided remarkable insights into the etiology of the disease. The pro-B, CD10 negative immunophenotype is typically found in infant acute leukemia, and the most common genetic alterations are the rearrangements of the MLL gene. In addition, the TEL/AML1 fusion gene is most frequently found in children older than 24 months. A ...
Tópico(s): Epigenetics and DNA Methylation
2007 - Associação Brasileira de Divulgação Científica | Brazilian Journal of Medical and Biological Research
Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A. Gorski, Stein Aerts, Ido Amit, Michela G. Bertero, Christoph Bock, Annelien L. Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M. Fernández, Marek Figlerowicz, Susan M. Gasser, Norbert Hübner, Jørgen Kjems, Juergen A. Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean‐Christophe Marine, John C. Marioni, Marc A. Martí‐Renom, Mihai G. Netea, Dörthe Nickel, Marcelo Nöllmann, Halina R. Novak, Helen Parkinson, Stefano Piccolo, Inês Pinheiro, Ana Pombo, Christian Popp, Wolf Reik, Sergio Román-Román, Philip Rosenstiel, Joachim L. Schultze, Oliver Stegle, Amos Tanay, Giuseppe Testa, Dimitris Thanos, Fabian J. Theis, Maria‐Elena Torres‐Padilla, Alfonso Valencia, Céline Vallot, Alexander van Oudenaarden, Marie Vidal, Thierry Voet,
A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03287-8.
Tópico(s): Biomedical Ethics and Regulation
2021 - Nature Portfolio | Nature
Produção Nacional
Revisado por pares
Jeniffer Dantas Ferreira, Arnaldo Cézar Couto, Luciana Correia Alves, Maria do Socorro Pombo de Oliveira, Sérgio Koifman,
O presente estudo objetiva explorar as relações inaparentes que diversos fatores relativos às exposições ambientais e características individuais existentes em nosso meio possam ter no processo de desenvolvimento da leucemia na infância. A partir de um banco de dados clínicos e epidemiológicos obtido com estudo caso-controle de base hospitalar sobre fatores de risco para leucemias na infância, foi realizada análise multivariada exploratória por meio do emprego de análise de componentes principais ...
Tópico(s): Acute Lymphoblastic Leukemia research
2012 - Brazilian Association of Population Studies | Revista Brasileira de Estudos de População
Produção Nacional
Revisado por pares
Jeniffer Dantas Ferreira, Arnaldo Cézar Couto, Mariana Emerenciano, Maria S. Pombo‐de‐Oliveira, Sérgio Koifman,
Objectives . To investigate the association between the maternal alcohol consumption during pregnancy and early age leukemia (EAL) in offspring. Methods . Datasets were analyzed from a case-control study carried out in Brazil during 1999–2007. Data were obtained by maternal interviews using a standardized questionnaire. The present study included 675 children (193 acute lymphoid leukemia (ALL), 59 acute myeloid leukemia (AML), and 423 controls). Unconditional logistic regression was performed, and adjusted ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2015 - Hindawi Publishing Corporation | BioMed Research International
Produção Nacional
Revisado por pares
Marzia Puccioni‐Sohler, María Rios, Sílvia Maia Farias de Carvalho, R. R. Gonçalves, Carlos Oliveira, Rosalie Branco Corrêa, Sérgio A. P. Novis, Maria S. Pombo‐de‐Oliveira, Celso Bianco,
The contribution of human T-cell lymphotropic virus (HTLV-I) DNA by PCR in CSF and the intrathecal synthesis of antibodies to HTLV-I by the antibody index (AI) to the diagnosis of HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) were evaluated. Cases of spastic paraparesis compatible with HAM/TSP had increased AI for HTLV-I (60/73) and HTLV-I proviral sequences in CSF (25/27). Among 27 patients with other neurologic diseases, three had increased AI and another three had positive HTLV- ...
Tópico(s): Vector-Borne Animal Diseases
2001 - Lippincott Williams & Wilkins | Neurology
Produção Nacional
Revisado por pares
Marzia Puccioni‐Sohler, María Rios, Celso Bianco, Shi Wei Zhu, Carlos Oliveira, Sérgio A. P. Novis, Maria S. Pombo‐de‐Oliveira,
The authors measured human T-cell lymphotrophic virus type I (HTLV-I) proviral load and intrathecal synthesis of antibodies to HTLV-I in CSF of 13 Brazilian patients with tropical spastic paraparesis/ HTLV-I-associated myelopathy (HAM). The authors also measured HTLV-I proviral load in peripheral blood mononuclear cells of five of these patients and found that it was 10- to 100-fold higher than that in CSF cells. The combination of HTLV-I proviral load and intrathecal synthesis of antibodies to HTLV- ...
Tópico(s): Vector-Borne Animal Diseases
1999 - Lippincott Williams & Wilkins | Neurology
Produção Nacional
Revisado por pares
Arnaldo Cézar Couto, Jeniffer Dantas Ferreira, Rosalina Jorge Koifman, Gina Torres Rego Monteiro, Maria S. Pombo‐de‐Oliveira, Sérgio Koifman,
OBJETIVO: Analisar a tendência de mortalidade por leucemias na infância, no estado do Rio de Janeiro, durante o período de 1980 a 2006. MÉTODO: Foram utilizados os dados de mortalidade por leucemia em menores de 15 anos do Sistema de Informações de Mortalidade do Ministério da Saúde para os anos de 1980 a 2006, segundo o sexo, dos residentes de três áreas: município do Rio de Janeiro (capital), região metropolitana (exceto capital) e interior do estado. Foram considerados como óbitos por leucemia ...
Tópico(s): Neutropenia and Cancer Infections
2010 - Elsevier BV | Jornal de Pediatria
Produção Nacional
Revisado por pares
Elizabeth Milne, Kathryn R. Greenop, Catherine Metayer, Joachim Schüz, Eleni Petridou, Maria S. Pombo‐de‐Oliveira, Claire Infante‐Rivard, Eve Roman, John D. Dockerty, Logan G. Spector, Sérgio Koifman, Laurent Orsi, Jérémie Rudant, Nick Dessypris, Jill Simpson, Tracy Lightfoot, Peter Kaatsch, Margarita Baka, Alessandra Faro, Bruce K. Armstrong, Jacqueline Clavel, Patricia A. Buffler,
Positive associations have been reported between the measures of accelerated fetal growth and risk of childhood acute lymphoblastic leukemia (ALL). We investigated this association by pooling individual-level data from 12 case-control studies participating in the Childhood Leukemia International Consortium. Two measures of fetal growth-weight-for-gestational-age and proportion of optimal birth weight (POBW)-were analysed. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2013 - Wiley | International Journal of Cancer
Produção Nacional
Revisado por pares
Márcia Rodrigues Amorim, Crisiane Wais Zanrosso, Isis Quezado Magalhães, Simone C. Pereira, Alexandre Figueiredo, Mariana Emerenciano, Vitória Régia Pereira Pinheiro, Maria Lydia d'Andréa, Iêda M. Orioli, Sérgio Koifman, Maria S. Pombo‐de‐Oliveira,
Down syndrome (DS) is an important risk factor associated with acute leukemia (AL). The presence of polymorphisms that reduce 5,10-methylenetetrahydrofolate reductase (MTHFR) activity has been linked to the multifactorial leukemogenic process. The authors have conducted a study to test whether 677C→T and/or 1298A→C polymorphisms of MTHFR would play an additional role in susceptibility of acute myeloid leukemia (AML) in DS children. They also verified whether any polymorphism in the MTHFR gene was associated ...
Tópico(s): Acute Myeloid Leukemia Research
2008 - Taylor & Francis | Pediatric Hematology and Oncology
Produção Nacional
Revisado por pares
Catherine Metayer, Elizabeth Milne, John D. Dockerty, Jacqueline Clavel, Maria S. Pombo‐de‐Oliveira, Catharina Wesseling, Logan G. Spector, Joachim Schüz, Eleni Petridou, Sameera Ezzat, Bruce K. Armstrong, Jérémie Rudant, Sérgio Koifman, Peter Kaatsch, Maria Moschovi, Wafaa M. Rashed, Steve Selvin, Kathryn McCauley, Rayjean J. Hung, Alice Y. Kang, Claire Infante‐Rivard,
Maternal prenatal supplementation with folic acid and other vitamins has been inconsistently associated with a reduced risk of childhood acute lymphoblastic leukemia (ALL). Little is known regarding the association with acute myeloid leukemia (AML), a rarer subtype.We obtained original data on prenatal use of folic acid and vitamins from 12 case-control studies participating in the Childhood Leukemia International Consortium (enrollment period: 1980-2012), including 6,963 cases of ALL, 585 cases of ...
Tópico(s): Gestational Diabetes Research and Management
2014 - Lippincott Williams & Wilkins | Epidemiology
Sergio Pombo-Alonso, Imanol Gabarain, Nuno Nunes, Gaspar de la Herrán,
The gold-standard treatment for Vancouver type B2 and B3 fractures is revision arthroplasty. This procedure can be prolonged and complex, posing challenges for patients with severe medical comorbidities and reduced physical status. Recently, osteosynthesis has been proposed as an alternative treatment for B2 periprosthetic femoral fractures (PFF) in frail patients, though its efficacy compared to revision arthroplasty has not been studied in detail.
Tópico(s): Orthopedic Infections and Treatments
2024 - Elsevier BV | Injury
Produção Nacional
Carlos Roberto Teixeira, Sheila Canevese Rahal, Antônio Fernando Martorelli de Lima, M. A. Corrêa, Paulo Sergio Mendes de Queiroz, L. C. Vulcano,
O trabalho teve por objetivo avaliar a utilização da haste intramedular de polipropileno, combinada ou não a biomateriais de origem bovina, no tratamento de fraturas transversas induzidas no terço médio do úmero direito de pombos-domésticos. No grupo I (n=7), a fratura foi estabilizada por meio de haste intramedular de polipropileno aplicada em ambos os fragmentos da fratura, sem ultrapassar as articulações. No grupo II (n=7) utilizou-se a mesma fixação, porém foi aplicado junto ao foco de fratura ...
Tópico(s): Shoulder Injury and Treatment
2004 - UNIVERSIDADE FEDERAL DO PARANÁ | Archives of Veterinary Science
Produção Nacional
Revisado por pares
Arnaldo Cézar Couto, Jeniffer Dantas Ferreira, Sérgio Koifman, Maria S. Pombo‐de‐Oliveira,
The objective of this study was to determine the contribution of a familial history of cancer (FHC) to the development of leukemia in children below 2 years of age. This is a national hospital-based case–control study of children 0–24 months of age recruited from 15 Brazilian hospitals from several regions providing oncological care and local general hospitals. Participants’ FHC antecedents were obtained through face-to-face interviews with the mothers of cases and controls using a standardized questionnaire. ...
Tópico(s): DNA Repair Mechanisms
2012 - Lippincott Williams & Wilkins | European Journal of Cancer Prevention
Produção Nacional
Revisado por pares
Catherine Metayer, Elizabeth Milne, Jacqueline Clavel, Claire Infante‐Rivard, Eleni Petridou, Malcolm Taylor, Joachim Schüz, Logan G. Spector, John D. Dockerty, Corrado Magnani, Maria S. Pombo‐de‐Oliveira, Daniel Sinnett, Michael Murphy, Eve Roman, Patricia Monge, Sameera Ezzat, Beth A. Mueller, Michael E. Scheurer, Bruce K. Armstrong, J M Birch, Peter Kaatsch, Sérgio Koifman, Tracy Lightfoot, Parveen Bhatti, Melissa L. Bondy, Jérémie Rudant, Kate A O’Neill, Lucia Miligi, Nick Dessypris, Alice Y. Kang, Patricia A. Buffler,
Background: Acute leukemia is the most common cancer in children under 15 years of age; 80% are acute lymphoblastic leukemia (ALL) and 17% are acute myeloid leukemia (AML). Childhood leukemia shows further diversity based on cytogenetic and molecular characteristics, which may relate to distinct etiologies. Case–control studies conducted worldwide, particularly of ALL, have collected a wealth of data on potential risk factors and in some studies, biospecimens. There is growing evidence for the role ...
Tópico(s): Epigenetics and DNA Methylation
2013 - Elsevier BV | Cancer Epidemiology