Jeremy Rundall, James Margach, Will Ellsworth-Jones, Beilen, John Fryer, Philip Norman, Harold Hobson, Chris Ryder, Rob Hughes, E. J. P. Lombard Knight, Micheal Jones, Sir Martin Lindsay, Julian Everitt, Roger Cawley, Robin Gregg, Graham Rose, Berry Ritchie, Peter Cadogan, Antony Terry, E. C. Jones, Steohen Fry, Dr Wilfred Beckerman, Colin Tilney, Peter Horrobin, Collin Simpson, Richard Streeton, Henry Brandon, Howard Watson, Dr Beverly Halstead, Deryk Brown, David Dougill, Edith Lenart, Cliff Temple, Philip Clarke, Derek Jewell, Patrick Campbell, Vivian Jenkins, Murray Sayle, Peter Watson, John Ballantine, Norman Harris, Gillian Widdicombe, Stonley Leyenson, Ruth Hall, Micheal Green, Geoff Whitten, Peter Kellner, Barry Cockcroft, Robin Marlar, Norman Lamont, Alee Ponton, Roger Eglin, Woodrow Wyatt, Irma Kurtiz, Peter Lennon, Michael Heseltine, Keith Rotsford, Julia Cave, Putrick Rowley, Louise, Leonard Barras, Micheal Roberts, Brian Jackman, Peter Gammond, Denis Herbstein, James Fox, Peter Wilsher, Sanjoy Roy-Chowdhury, John Morris, Desmond Shawe-Taylor, C A Johnson, Melanie Friesen, Ben Folley, Gwen Nuttall, Stephen Aris, Mica Panic Chief Economist, Dilys Powell, Brough Scott, Oliver Gillie, Tony Rocca, Gordon Best, Elkan Allan, Elakan Allan, Hugo Young, Tim Brown, Ian Nairn, Felix Aprahamian, Denis Herstein, Jack Fingleton, Ian Jack, J W Lambert, Henry Longhurst, Godfrey Hodson, William Allsopp, Peter Draper, Peggy Crane, Peter Kenyon, Peter Clarke, Peter Pringle, Richard Burnell, Christopher Ricks, Bernard Keeffe, Brian Glanville, Helgi P Brlem, R Gilmore Machynlleth, Anthony Holden, Simon Jenkins, Graham Searjeant, Maureen Walker, Juson Tomas, Roman Eisenstein, Marina Vaizey, Chris Lightbown, Robert Whymant, Allan Hall, Philip Radcliffe, Peter Sedwick, Bill Glendon, Malcolm Crawford, Roland Adburgham, Hugh Trevor-Roper, Boris Schapiro,
... Jack Barclay(Service)Ltd Multiple Classified Advertising Items Sdh. R. Owen Multiple Classified Advertising Items Multiple Display ...
1975 - Gale Group | Sunday Times HA GDA
Walter G. Wiest, William R. Kidwell, Károly Balogh,
... these enzyme activities have been examined. 20α-OH-SDH activity and 20α-OH-P concentrations decreased during ... 20α-OH-P. No increase in 20α-OH-SDH was evident at this time. Between days 19 ... with a rapid rise in ovarian 20α-OH-SDH and peripheral 20α-OH-P concentration. A high ... 20α-OH-P concentrations and ovarian 20α-OH-SDH activities. Uterine and placental steroid concentrations reflected the ... an intense histochemical reaction for both 20α-OH-SDH and G-6-PDH, but only G-6- ... its disappearance from involuting corpora lutea. 20α-OH-SDH was not detectable histochemically during midgestation. On day ...
Tópico(s): Reproductive System and Pregnancy
1968 - Oxford University Press | Endocrinology
IEEE Xplore
Blanka Rutberg, Lars Hederstedt, Erik Holmgren, Lars Rutberg,
Eleven succinic dehydrogenase (SDH) mutants in Bacillus subtilis were analyzed by crossed immunoelectrophoresis with antiserum prepared against wild-type B. subtilis cytoplasmic membrane. A precipitate which stained for SDH was found in Triton X-100-solubilized wild- ... membranes and in membranes from two of the SDH mutants. The remaining nine mutants did not show an SDH-staining precipitate. The respective mutations in these nine ... al., J. Bacteriol. 115:738-745, 1973). An SDH-specific antiserum was prepared by immunizing rabbits with ...
Tópico(s): Protein purification and stability
1978 - American Society for Microbiology | Journal of Bacteriology
Directory of Open Access Journals (DOAJ)
Federico Dajas, Daniel Rodrı́guez-Ithurralde, D. Cibils, Rodolfo Silveira, Jorge Vercelli, L.P. Arias,
... the enzyme his‐tochemical tests for succinic dehydrogenase (SDH), lactic dehydrogenase (LDH), thiaminopyrophosphatase (TPPase), acid phosphatase (AcPase), ... enzymatic activity was detected in the pyramidal neurons (SDH, LDH, AcPase, and TPPase). Mg 2+ ATPase showed ... second group (more than 10 hr of HSE), SDH was found decreased in the dendritic fields. LDH ... third group (more than 18 hr of HSE), SDH activity was low. No AcPase granules were observed ... en particulier 1'activite de la succino dehydrogenase (SDH), de la lactico dehydrogenase (LDH), de la thiamine‐ ...
Tópico(s): Aldose Reductase and Taurine
1978 - Wiley | Epilepsia
Directory of Open Access Journals (DOAJ)
Lars Hederstedt, Karl‐Eric Magnusson, Lars Rutberg,
Bacillus subtilis succinate dehydrogenase (SDH) is composed of two unequal subunits designated Fp (Mr, 65,000) and Ip (Mr. 28,000). The enzyme is structurally ... the membrane. A total of 21 B. subtilis SDH-negative mutants were isolated. The mutants fall into ... presence and localization of the subunits of the SDH-cytochrome b558 complex. One class contains mutants with ... inactive membrane-bound complex. Membrane-bound enzymatically active SDH could be reconstituted in fused protoplasts of selected pairs of SDH-negative mutants. Most likely reconstitution is due to ...
Tópico(s): Probiotics and Fermented Foods
1982 - American Society for Microbiology | Journal of Bacteriology
Karl‐Eric Magnusson, Lars Hederstedt, Lars Rutberg,
... is a transmembrane protein which anchors succinate dehydrogenase (SDH) to the cytoplasmic membrane and is reduced by ... derived plasmids were used to transform B. subtilis SDH mutants to chloramphenicol resistance by integration of the ... Of some 3,000 transformants tested, 6 were SDH positive and had pHV32 integrated close to the sdh operon. Two plasmids, pKIM2 and pKIM4, with an ... by transforming E. coli with DNA from the SDH-positive transformants after cleavage with EcoRI or BglII ... the iron-sulfur protein subunit of B. subtilis SDH. Enzymatically active, membrane-bound B. subtilis SDH could ...
Tópico(s): Enzyme Structure and Function
1985 - American Society for Microbiology | Journal of Bacteriology
Vinay Shenoy, D. V. Seshu, J. K. S. Sachan,
... shikimate dehydrogenase high mobility allozyme (specified by the Sdh‐1 2 allele) was associated with higher protein ... derived from a cross involving parents differing in Sdh‐1 alleles and seed protein content, and to examine the influence of the Sdh‐1 2 allele on the Osborne's solubility ... The female parent IR36 was characterized by the Sdh‐11 allele and low seed protein content, and ... parent IR480‐5‐9‐3‐3, by the Sdh‐1 2 allele and high seed protein content. ... were divided into three groups based on their Sdh‐1 allozyme pattern as determined by starch gel ...
Tópico(s): GABA and Rice Research
1990 - Wiley | Crop Science
Lars Melin, Lars Rutberg, Alexander von Gabain,
The amount of succinate dehydrogenase (SDH) in Bacillus subtilis varies with growth conditions. In this work we studied the steady-state level and the rate of decay of B. subtilis sdh mRNA under different growth conditions. In exponentially growing cells, the steady-state level of sdh mRNA was severalfold lower when glucose was present ... without glucose, whereas the rate of decay of sdh mRNA was the same with and without glucose. Thus, glucose repression seems to act by decreasing sdh mRNA synthesis. When the bacteria entered the stationary ...
Tópico(s): Protein Structure and Dynamics
1989 - American Society for Microbiology | Journal of Bacteriology
Miguel A. Lanaspa, Ana Andres‐Hernando, Christopher J. Rivard, Yue Dai, Nanxing Li, Tomás Berl,
... be a potential negative regulator of sorbitol dehydrogenase (SDH) in hippocampal cells, we examined whether this relationship ... to varying levels demonstrated an inverse effect on SDH expression. ZAC1 binds to a consensus repression site within the promoter of SDH, pointing to a mechanism whereby ZAC1 acts by repressing SDH transcriptional activity during hypertonic conditions. Taken together, these ... under hypertonic stress and negatively regulates expression of SDH, allowing for accumulation of sorbitol as a compatible ...
Tópico(s): Ion Transport and Channel Regulation
2009 - Elsevier BV | Journal of Biological Chemistry
Wayne B. Anderson, Brett A. Graham, Natalie J. Beveridge, Paul A. Tooney, Alan M. Brichta, Robert J. Callister,
Background Neurons in superficial (SDH) and deep (DDH) laminae of the spinal cord dorsal horn receive sensory information from skin, muscle, joints and viscera. In ... of GlyR, (containing alpha 3 subunits) in the SDH. The contribution of differing forms of the GlyR to sensory processing in SDH and DDH is not understood. Methods and Results ... fast inhibitory synaptic transmission in mouse (P17-37) SDH and DDH using patch-clamp electrophysiology in transverse ... 74% (25/34) and 94% (25/27) of SDH and DDH neurons, respectively. In contrast, GABA A ...
Tópico(s): Ion channel regulation and function
2009 - SAGE Publishing | Molecular Pain
Jie Li, Wenrui Xie, Jun‐Ming Zhang, Mark L. Baccei,
... synaptic efficacy in the immature superficial dorsal horn (SDH) of the spinal cord, or whether the neonatal SDH network is sensitive to the proinflammatory cytokine TNFα ... transmission and intrinsic membrane excitability in developing rat SDH neurons in the absence or presence of sciatic ... excitatory (mEPSCs) or inhibitory (mIPSCs) postsynaptic currents in SDH neurons at P9-11. However, SNI did alter the sensitivity of excitatory synapses in the immature SDH to TNFα. While TNFα failed to influence mEPSCs ...
Tópico(s): Ion channel regulation and function
2009 - SAGE Publishing | Molecular Pain
Banzragch Battur, Damdinsuren Boldbaatar, Rika Umemiya‐Shirafuji, Min Liao, Badgar Battsetseg, DeMar Taylor, Badarch Baymbaa, Kozo Fujisaki,
Background Lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) is a bifunctional enzyme catalyzing the first two steps of lysine catabolism in plants and mammals. However, to date, the properties of the lysine degradation pathway and biological functions of LKR/SDH have been very little described in arthropods such ... EC 1.5.1.8) and saccharopine dehydrogenase (SDH, EC 1.5.1.9) from a tick, ... domains similar to the plant and mammalian LKR/SDH enzymes. Expression of LKR/SDH was detected in ...
Tópico(s): Insect and Pesticide Research
2009 - Public Library of Science | PLoS ONE
... the flavination of SDHA, which is necessary for SDH assembly and function. Moreover, they detected SDH5 mutations ... the flavination of SDHA, which is necessary for SDH assembly and function. Moreover, they detected SDH5 mutations ... discovery that the Krebs cycle components succinate dehydrogenase (SDH) and fumarate hydratase (FH) are targets of germline ... studies prove that metabolic deregulation can cause cancer. SDH is a heteroligomer containing the subunits SDH A, B, C, and D and mutations of ... that are not yet clear, is required for SDH complex assembly and function. Loss of SDH5 in ...
Tópico(s): Hormonal Regulation and Hypertension
2009 - Cell Press | Cancer Cell
Ryuhei Kanamoto, Yeu Su, Henry C. Pitot,
... glucagon but not dexamethasone could induce serine dehydratase (SDH: EC.4.2.1.13) in liver, and ... The mechanism(s) of the hormonal regulation of SDH gene expression in liver and kidney was further ... glucagon and dexamethasone induced the activity, rate of SDH synthesis, and accumulation of SDH mRNA in both liver and kidney of the rat. The increased SDH activity was reflected by changes in the amount of enzyme protein and in the rate of SDH protein synthesis, both parameters closely paralleling the changes ...
Tópico(s): Diet, Metabolism, and Disease
1991 - Oxford University Press | Molecular Endocrinology
Kurt J. Henle, William A. Nagle,
... this phenomenon is known as the stepdown heating (SDH) effect. We characterized the SDH effect on (1) the synthesis of major heat ... C) hyperthermia, primarily in the soluble cytosol fraction. SDH (10 min, 45 °C + 1 to 6 h, ... chronic hyperthermia alone. At the cell survival level, SDH increased sevenfold the rate of cell killing at ... only a factor of two. This suggests that SDH sensitization did not result from changes in HSP72/ ... pellet fraction after both acute and chronic hyperthermia. SDH completely inhibited 35S-labeling of both HSP60 and ...
Tópico(s): Protein Structure and Dynamics
1991 - Elsevier BV | Experimental Cell Research
Gordon Chalmers, Roland R. Roy, V. Reggie Edgerton,
... determine the level of coordination in succinate dehydrogenase (SDH) activity between plantaris motoneurons and muscle fibers, the ... injected with horseradish peroxidase to identify plantaris motoneurons. SDH activity then was measured in a population of ... Control motoneurons and muscle fibers had similar mean SDH activities and a similar relationship between cell size and SDH activity. After FO, muscle fiber size doubled and mean muscle fiber SDH activity halved. Motoneuron mean SDH activity and size ...
Tópico(s): Veterinary Orthopedics and Neurology
1991 - American Physiological Society | Journal of Applied Physiology
... phenomenon, which is known as step-down heating (SDH) or thermosensitization, has been observed both in cultured ... and normal tissues in vivo. The effect of SDH increases with a lowering of TT temperature, but ... lost at temperatures very close to 37°C. SDH-induced thermosensitization decays within a few hours, when ... vitro results suggest an exponential decay of the SDH effect with half times ranging from 1·5- to 3·1 h. The effect of SDH increases with increasing ST time or temperature. For ... region 42·5–43·0°C, respectively. For SDH, the Arrhenius plot gradually becomes monophasic with increasing ...
Tópico(s): Infrared Thermography in Medicine
1992 - Taylor & Francis | International Journal of Hyperthermia
Natacha Bochud‐Allemann, Andreá Schneider,
... Google Scholar). Succinate is oxidized by succinate dehydrogenase (SDH),1 which transfers the electrons to the cytochrome ... parameter settings to search for the genes for SDH, α-ketoglutarate dehydrogenase (KDH), SCoAS, and pyruvate dehydrogenase ( ... coding region of the flavoprotein subunit of the SDH and the E1 subunit of the KDH gene ... in Fig. 4, in the RNAi constructs for SDH and KDH, we have replaced the pleomycine resistance ... knock-down cell lines.Cell lines ablated for SDH (A), KDH (B), SCoAS (C), and PDH (D) ...
Tópico(s): Mosquito-borne diseases and control
2002 - Elsevier BV | Journal of Biological Chemistry
Xiaohong Zhu, Guiliang Tang, Gad Galili,
Lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) is a bifunctional enzyme catalyzing the first two steps of lysine catabolism in animals and plants. To elucidate the biochemical signification of the linkage between the two enzymes of LKR/SDH, namely lysine ketoglutarate and saccharopine dehydrogenase, we employed various truncated and mutatedArabidopsis LKR/SDH polypeptides expressed in yeast. Activity analyses of the ... varying NaCl levels implied that LKR, but not SDH activity, is regulated by functional interaction between the ...
Tópico(s): Plant Gene Expression Analysis
2002 - Elsevier BV | Journal of Biological Chemistry