Lihui Zhu, Rongrong Liao, Jiwen Huang, Changfeng Xiao, Yunzhou Yang, Huiying Wang, Daqian He, Huaxiang Yan, Changsuo Yang,
... we screened a new probiotic strain, Lactobacillus salivarius SNK-6 (L. salivarius SNK-6), which was isolated from the ileum of ... We investigated the beneficial activity of L. salivarius SNK-6 in a NAFLD model in laying hens and found that L. salivarius SNK-6 inhibited liver fat deposition and decreased serum ... NAFLD laying hens but reversed after L. salivarius SNK-6 treatment. Downregulation of MBOAT2, L. salivarius SNK-6 supplementation in vivo, and L. salivarius SNK-6 cell culture treatment in vitro suppressed the ...
Tópico(s): Gut microbiota and health
2022 - Multidisciplinary Digital Publishing Institute | Cells
Mitsuru Ono, Tetsuya Shimizugawa, Mitsuru Shimamura, Kenichi Yoshida, Chisa Noji-Sakikawa, Yukio Ando, Ryuta Koishi, Hidehiko Furukawa,
... Scopus (202) Google Scholar). We reported that KK/Snk mice (previously, KK/San) had abnormally low plasma ... the cause of the hypolipidemic phenotype of KK/Snk mice (7Shiraki T. Yoshioka S. Horikoshi H. Diabetes ... low density lipoprotein clearance was enhanced in KK/Snk mice and that recombinant ANGPTL3 directly inhibited lipoprotein ... polyclonal antibody as a probe. Animal Assay—KK/Snk mice were established as previously described (7Shiraki T. ... We injected a recombinant adenovirus intravenously to KK/Snk mice via the tail vein. We obtained blood ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2003 - Elsevier BV | Journal of Biological Chemistry
Thierry Rose, Ellen K. LeMosy, Angelene M. Cantwell, Dolly Banerjee-Roy, James B. Skeath, Enrico Di,
... domains of Nudel (Ndl), Gastrulation Defective (Gd), Snake (Snk), and Easter (Ea), and their complexes with substrate ... fly embryo. The models predict that Gd activates Snk, which in turn activates Ea. Gd can be ... domains of Nudel (Ndl), Gastrulation Defective (Gd), Snake (Snk), and Easter (Ea), and their complexes with substrate ... fly embryo. The models predict that Gd activates Snk, which in turn activates Ea. Gd can be ... domains of the trypsin family. Easter (Ea),1 Snk, Gd, and Ndl are expressed and secreted during ...
Tópico(s): Enzyme Production and Characterization
2003 - Elsevier BV | Journal of Biological Chemistry
Marianne Dissing, Heidi Giordano, Robert DeLotto,
... Three serine protease zymogens, Gastrulation defective (GD), Snake (Snk) and Easter (Ea), and a nerve growth factor- ... the cascade and that interaction between GD and Snk is sufficient for GD to cleave itself autoproteolytically. ... biochemical feedback in the pathway. Both GD and Snk bind to heparin–Sepharose, providing a link between ... PVS. The genes include gastrulation defective (gd), snake (snk), easter (ea) and spaetzle (spz); epistasis indicates that ... cloning of the genes has shown that gd, snk and ea encode the zymogen or inactive precursor ...
Tópico(s): Developmental Biology and Gene Regulation
2001 - Springer Nature | The EMBO Journal
... access The polo-like protein kinases Fnk and Snk associate with a Ca2+- and integrin-binding protein ... and structure. Here we demonstrate that Fnk and Snk, two members of the polo family of cell ... levels of both kinase mRNAs. Induced Fnk and Snk proteins are targeted to the dendrites of activated ... family consists of three members, Plk, Fnk and Snk. Whereas the function of Snk is less clear, Plk and Fnk have been ... Our studies suggest a role for Fnk and Snk outside the cell cycle. Whereas we do not ... of Plk in the brain, both Fnk and Snk are constitutively expressed in post-mitotic neurons. Moreover, ...
Tópico(s): RNA Research and Splicing
1999 - Springer Nature | The EMBO Journal
Lin Chen, Ye Zhao, Tianlong Zhang, Xuan Dang, Xie Renming, Zhenzhi Li, Yang Li, Yuli Li, Wen‐Na Zhao, Hongru Song,
Sheng-Nao-Kang decoction (SNK), a modified traditional Chinese medicine (TCM), has been used clinically for the treatment of acute and chronic cerebrovascular related diseases. To evaluate the protective effect of SNK on focal cerebral ischemia-reperfusion (I/R) injury ... kinds of groups: Sham group; I/R group; SNK-treated groups at doses of 0.7 g/ ... detect the caspase-3 protein content in rats. SNK administration significantly reduced the neurological defect scores and lessened the cerebral infarction volume. The treatment of SNK lowered MDA content, up-regulated SOD and GSH- ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2013 - Elsevier BV | Journal of Ethnopharmacology
Leonidas Benetatos, Aggeliki Dasoula, Eleftheria Hatzimichael, Nelofer Syed, Maria Voukelatou, George Dranitsaris, Konstantinos L. Bourantas, Tim Crook,
Polo-like kinase 2 (SNK/PLK2), a transcriptional target for wild-type p53 and is hypermethylated in a high percentage of multiple myeloma and B ... and correlated the results with hypermethylation in the SNK/PLK2 CpG island. The SNK/PLK2 CpG island was hypermethylated in 68.9% ... different MTHFR genotypes and susceptibility to develop AML. SNK/PLK2 hypermethylation combined with the MTHFR AA1298 genotype ... tendency for a better OS. Similarly, patients with SNK/PLK2 hypermethylation combined with the MTHFR CT677 polymorphism ...
Tópico(s): Cancer Genomics and Diagnostics
2011 - Springer Science+Business Media | Annals of Hematology
Guihua Zhang, Faan Miao, Jinge Xu, Yan Zhang,
... Killer/T (NK/T)-cell lymphoma cell line SNK-6, and the activation of downstream signaling pathway. ... tissues were obtained from lymphoma patients. Proliferation of SNK-6 cells was detected by CCK8 or MTT ... cell nuclear antigen (PCNA) and Ki67 levels of SNK-6 cells. Losartan, an antagonist of AT1R, reduced ... viability and the PCNA and Ki67 levels of SNK-6 cells. The levels of phosphorylated phosphatidylinositol 3- ... Ang II and then reduced by losartan in SNK-6 cells. The proliferation and viability of SNK-6 cells were increased by Ang II, but ...
Tópico(s): Cancer Mechanisms and Therapy
2020 - Portland Press | Bioscience Reports
Qingyu Fan, Jing‐Jie Liu, Guilian Zhang, Haiqin Wu, Ru Zhang, Shuqin Zhan, Na Liu,
... divided into model, SNKMCAO-del and pcDNA3.1-SNK groups. The evaluation of motor function among the ... was employed to evaluate the effect of the SNK signaling pathway on rat motor function. Triphenyltetrazolium chloride ( ... performed to detect mRNA and protein expressions of SNK and SPAR. When compared with the model group, ... contrasting results were observed in the pcDNA3.1-SNK group. According to the results obtained from the ... to the model group whereas the pcDNA3.1-SNK group exhibited poorer results than the model group ...
Tópico(s): Mesenchymal stem cell research
2017 - Wiley | Journal of Cellular Biochemistry
Thomas Kwong, Nathan Zelyas, Hui Cai, Kapil Tahlan, Annie Wong, Susan E. Jensen,
... region downstream of the cluster was analyzed, and snk, res1, and res2, encoding elements of an atypical ... had no effect on clavulanic acid production, but snk and res2 mutants produced no 5S clavams, whereas ... and 5S clavam biosynthetic genes was eliminated in snk and in res2 mutants but that snk and res2 transcription was unaffected in a cvm7p mutant. Both snk and res2 mutants could be complemented by introduction ... independently regulated promoter. In vitro assays showed that Snk can autophosphorylate and transfer its phosphate group to ...
Tópico(s): Bacterial Genetics and Biotechnology
2012 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Nelofer Syed, Paul J. Smith, Alexandra Sullivan, Lindsay C. Spender, Martin J.S. Dyer, Lorraine Karran, Jenny O’Nions, Martin J. Allday, Ingrid Hoffmann, Dorothy H. Crawford, Beverley E Griffin, Paul J. Farrell, Tim Crook,
... human neoplasia is lacking. Here, we report that Snk/Plk2 is transcriptionally down-regulated in B-cell ... island located at the 5' end of the SNK/PLK2 gene. Silencing is specific to malignant B cells because SNK/PLK2 was unmethylated (and expressed) in primary B ... carcinomas (of the head and neck). Expression of Snk/Plk2 in BL cell lines was restored by ... genes were overexpressed in BL cell lines lacking Snk/Plk2 expression, consistent with functional degeneracy among the Plk family. Ectopic expression of Snk/Plk2 in BL cells resulted in apoptosis, a ...
Tópico(s): Microtubule and mitosis dynamics
2005 - Elsevier BV | Blood
Timothy F. Burns, Peiwen Fei, Kimberly A. Scata, David T. Dicker, Wafik S. El‐Deiry,
... Polo-like kinase family member serum inducible kinase (Snk/Plk2) as a novel p53 target gene. Snk/Plk2 mutagenesis demonstrated that its kinase activity is ... its C terminus. Small interfering RNA (siRNA)-mediated Snk/Plk2 silencing in the presence of the mitotic ... demonstrated that the apoptosis due to silencing of Snk/Plk2 in the face of spindle damage occurs ... like state without dividing. Since siRNA directed against Snk/Plk2 promoted death of paclitaxel-treated cells in ... a mitotic checkpoint wherein p53-dependent activation of Snk/Plk2 prevents mitotic catastrophe following spindle damage. Finally, ...
Tópico(s): Cell death mechanisms and regulation
2003 - Taylor & Francis | Molecular and Cellular Biology
Yukio Ando, Tetsuya Shimizugawa, Shigehito Takeshita, Mitsuru Ono, Mitsuru Shimamura, Ryuta Koishi, Hidehiko Furukawa,
KK/Snk mice (previously KK/San) possessing a recessive mutation (hypl) of the angiopoietin-like 3 (Angptl3) gene homozygously ... catabolism and clearance of TG-rich lipoproteins. KK/Snk mice (previously KK/San) possessing a recessive mutation ( ... hyperlipidemia, and diabetes, we found mutant mice (KK/Snk, previously KK/San) that were characterized by a ... for the mutation, named hypolipidemia (hypl), in KK/Snk mice identified a 4 bp nucleotide insertion in ... Cell. 1996; 87: 1161-1169Google Scholar). In KK/Snk mice with the homozygous hypl mutation, Angptl3 expression ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2003 - Elsevier BV | Journal of Lipid Research
Kuniharu Mizuno, Noriaki Kato, Akira Matsubara, Kazumasa Nakano, Masayasu Kurono,
... 5′-dioxospiro[chroman-4,4′-imidazolidine]-2-carboxamide (SNK-860), on the slowing of motor nerve conduction ... injection. In the following 2 weeks, treatment with SNK-860 improved MNCV in a dose-dependent manner. The efficacy of 1 mg/kg SNK-860 was equipotent to that of 20 mg/ ... in sciatic nerves of diabetic rats. Administration of SNK-860 for 14 days beginning 2 weeks after ... these metabolic abnormalities in a dose-dependent manner. SNK-860 restored all of these parameters to normal ... Therefore, it is suggested that the effect of SNK-860 on the slowing of MNCV results from ...
Tópico(s): Pain Mechanisms and Treatments
1992 - Elsevier BV | Metabolism
Shunling Guo, Guohe Tan, Shuai Li, Xuewen Cheng, Ya Zhou, Yun‐Fang Jia, Hui Xiong, Jiong Tao, Zhi‐Qi Xiong,
Serum inducible kinase (SNK), also known as polo-like kinase 2 (PLK2), is a known regulator of mitosis, synaptogenesis and synaptic homeostasis. However, ... cortical development is unknown. Herein, we show that snk is expressed in the cortical plate from embryonic ... in the ventricular/subventricular zones (VZ/SVZ), and SNK protein localizes to the soma and dendrites of cultured immature cortical neurons. Loss of SNK impaired dendritic but not axonal arborization in a ... both in vitro and in vivo. Overexpression of SNK also caused abnormal branching of the leading process ...
Tópico(s): Neuroscience and Neuropharmacology Research
2011 - Springer Nature | Cell Research
Lanxiang Wu, Changkai Sun, Yumei Zhang, Ming Fan, Jing Xu, Hui Ma, Zhang Jian,
The serum-induced kinase (Snk)-spine-associated Rap GTPase-activating protein (SPAR) signaling pathway is reported as a new molecular mechanism in activity-dependent remodeling of synapses. However, the relationship between Snk-SPAR pathway and glutamate-induced excitotoxicity is not ... hippocampal neurons, glutamate stimulation induces the activation of Snk-SPAR pathway, and leads to a loss of mature dendritic spines. The time-dependent changes in Snk and SPAR expression after glutamate exposure are also ...
Tópico(s): Ion channel regulation and function
2007 - Elsevier BV | Brain Research
Yuchen Liu, Lianhong Li, Huaxiang Yan, Zhonghua Ning, Zhong Wang,
... the effects of supplementary Lactobacillus salivarius (L. salivarius) SNK-6 on laying performance, the immune-related gene ... regimes: basal diet (Con), the low L. salivarius SNK-6 group (T1: 1.0 × 106 CFU/g), and the high L. salivarius SNK-6 group (T2: 1.0 × 107 CFU/g). ... rRNA gene sequencing indicated that supplementary L. salivarius SNK-6 had no significant difference in α -diversity ... mucosal immune responses. Overall, dietary supplementary L. salivarius SNK-6 can display an immunomodulatory function, possibly by ...
Tópico(s): Pharmacological Effects of Natural Compounds
2022 - Multidisciplinary Digital Publishing Institute | Microorganisms
Luke O’Brien, Kieran Collins, Farzad Amirabdollhian,
... meet energy and carbohydrate recommendations. Sports nutrition knowledge (SNK) can influence the dietary intake of athletes, and ... study was to investigate the current level of SNK in elite Gaelic footballers (n = 100). An online ... Knowledge Questionnaire (NSKQ) was used to assess sports SNK. The overall mean SNK scores for Gaelic footballers and practitioners were 47. ... that there is a major gap in the SNK of Gaelic footballers, while practitioners demonstrated a promising SNK, that could support Gaelic footballers. There is a ...
Tópico(s): Exercise and Physiological Responses
2021 - Multidisciplinary Digital Publishing Institute | Nutrients
... beta-peptide (Abeta)-induced neurotoxicity, serum-inducible kinase (SNK)-spine-associated Rap guanosine triphosphatase activating protein (SPAR) ... RNA extracting. Then the mRNA expression levels of SNK, SPAR and NMDAR subunits NR1, NR2A and NR2B ... exposure, we found that the expression level of SNK mRNA was up-regulated and the expression levels ... ZBPYR-containing serum pretreatment, the expression level of SNK mRNA was down-regulated and the levels of ... 0.05).Abeta-induced neurotoxicity was related to SNK-SPAR pathway and NMDAR; ZBPYR-containing serum can ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2009 - Elsevier BV | Journal of Chinese Integrative Medicine
Maria Luisa Centeno, Rachel L. Sanchez, Arubala P. Reddy, Judy L. Cameron, Cynthia L. Bethea,
... compared with ANOVA and Student-Newman-Keul’s (SNK) post hoc comparison. <i>Results:</i> CRH mRNA ... animals compared to HSR animals (p < 0.05, SNK). There was a significant increase in average and ... compared to the HSR group (p < 0.05, SNK). There was also a significant increase in CRH ... compared to the HSR group (p < 0.05, SNK). In the CM-Sf, the average CRH optical ... than in the HSR group (p < 0.05, SNK). In the central nucleus of the amygdala, the ... the MSR or HSR groups (p < 0.05, SNK). There was no difference between the groups in ...
Tópico(s): Regulation of Appetite and Obesity
2007 - Karger Publishers | Neuroendocrinology
Satomi Yogosawa, Shigetsugu Hatakeyama, Keiichi I. Nakayama, Hiroyuki Miyoshi, Shinichi Kohsaka, Chihiro Akazawa,
Serum-inducible kinase (SNK) is a member of polo-like kinases that serve as regulators of multiple events during cell division. Rapid changes in the activity and abundance of SNK were reported after the serum stimulation and after ... the detailed mechanisms that control the level of SNK protein have not been fully elucidated. In this ... Using the yeast two-hybrid screening, we identify SNK as a candidate substrate of hVPS18. The half-life of SNK is increased in HeLa cells that down-regulated ... may play an important role in regulation of SNK activity through its ubiquitin ligase.
Tópico(s): Microtubule and mitosis dynamics
2005 - Elsevier BV | Journal of Biological Chemistry
Yu Zhang, Hiroshi Nagata, Tatsuro Ikeuchi, Hiroyuki Mukai, Michiko K. Oyoshi, Ayako Demachi, Tomohiro Morio, Hiroshi Wakiguchi, Nobuhiro Kimura, Norio Shimizu, Kohtaro Yamamoto,
... natural killer (NK) cell clones. Three cell clones, SNK‐1, ‐3 and ‐6, were derived from patients ... nasal T/NK‐cell lymphomas; two cell clones, SNK‐5 and ‐10, were isolated from patients with ... EBV infection (CAEBV); and the other cell clone, SNK‐11, was from a patient with hydroa vacciniforme ( ... number of EBV‐terminal repeats showed that the SNK cell clones had monoclonal EBV genomes identical to ... EBV‐infected cells of the respective patients, and SNK cells had the type II latency of EBV ... chromosome 6q in five out of the six SNK cell clones, while 6q was not deleted in ...
Tópico(s): Immune Cell Function and Interaction
2003 - Wiley | British Journal of Haematology
Eri Kubo, NORIO MIYOSHI, Masaru Fukuda, Yoshio Akagi,
... Effects of treatment with aldose reductase inhibitor (ARI) SNK-860 on free radical formation were determined in ... rats. *OH production was completely inhibited by ARI SNK-860 in both galactose groups. Polyol accumulated in ... first 2 weeks, and was significantly inhibited by SNK-860. The increase in *OH production was considered ... accumulation in both galactose groups. The dose of SNK-860 to inhibit *OH by 50% level was ... the method of kinetic competition in vitro experiment. SNK-860 is not an effective *OH scavenger compared ...
Tópico(s): Connexins and lens biology
1999 - Elsevier BV | Experimental Eye Research
Norio Hotta, N. Koh, Fumihiko Sakakibara, Jiro Nakamura, Yuichi Hamada, Keiji Naruse, Hodaka Sasaki, K Mizuno, Akihisa Matsubara, Hironobu Kakuta, al. et,
... determine the effect of an aldose reductase inhibitor, SNK‐860, on the worsening of the electroretinogram (ERG) ... state, rats with streptozotocin‐induced diabetes were administered SNK‐860 (1 or 4 mg kg‐1 orally) daily for 4 weeks. The effectiveness of SNK‐860 in prolonging the peak latencies of oscillatory ... different waveform components (designated O1, O2 and O3). SNK‐860 (4 mg kg‐1 day‐1) either ... a better understanding of the mechanism by which SNK‐860 acts may provide new insight into the ...
Tópico(s): Nitric Oxide and Endothelin Effects
1995 - Wiley | Experimental Physiology
Wee Lun Foo, Mark A. Faghy, S. Andy Sparks, Josh W. Newbury, Lewis A. Gough,
... nutrition education intervention on the sports nutrition knowledge (SNK) of highly trained UK adolescent swimmers. Fifteen national ... nutrition student delivered all nutrition education sessions and SNK questionnaires were administered to the participants pre- and post-intervention. The mean total SNK score improved by 8.3% (SD = 8.4%, ... individual basis, ten swimmers significantly improved their total SNK score, whereas four swimmers did not improve, and ... a nutrition education intervention can positively influence the SNK of highly trained adolescent swimmers.
Tópico(s): Exercise and Physiological Responses
2021 - Multidisciplinary Digital Publishing Institute | Nutrients
Xiaoyang Ma, Yoon-Jung Shin, Hyo-Min Jang, Min-Kyung Joo, Jong-Wook Yoo, Dong Hyun Kim,
... natural killer cell cytotoxicity against YAC-1 cells (sNK-C) and peritoneal macrophage phagocytosis against Candida albicans ( ... P) activities, while cyclophosphamide and ampicillin treatments suppressed sNK-C and pMA-P activities. However, LPS, ampicillin, ... NK210 and/or NK219 significantly reduced LPS-induced sNK-C, pMA-P, and IFN-γ expression, while cyclophosphamide- or ampicillin-suppressed sNK-C and pMA-P activities, cyclophosphamide-suppressed IFN- ... ratio in vitro and in vivo, and enhanced sNK-C and pMA-P activities in normal control ...
Tópico(s): Immune Response and Inflammation
2021 - Nature Portfolio | Scientific Reports
Ryan Tam, Kathryn L. Beck, Janelle Gifford, Victoria Flood, Helen O’Connor,
Background: Sports nutrition knowledge (SNK) is essential for athletes to support selection of a diet to optimize sports performance. Unfortunately, assessment of SNK is limited by a lack of well-validated instruments. Valid assessment of SNK would assist in identifying gaps in athlete knowledge, ... to develop and conduct content validation on a SNK questionnaire for athletes.Methods: Focus groups (FG) with ... assessment domains including general nutrition knowledge along with SNK and supported development of an electronic instrument with ...
Tópico(s): Motivation and Self-Concept in Sports
2020 - Taylor & Francis | Journal of the American College of Nutrition
Weijia Zhi, Ruiyun Peng, Haijuan Li, Yong Zou, Binwei Yao, Changzhen Wang, Zong-Huan Liu, Xiaohui Gao, Xinping Xu, Ji Dong, Li Zhao, Hongmei Zhou, Lifeng Wang, Xiangjun Hu,
... which is associated greatly with dendritic spines plasticity. SNK-SPAR is a molecular pathway for neuronal homeostatic ... as well as the related critical molecules of SNK-SPAR pathway were examined at different time points ... 30 mW/cm2 microwave radiation, the up-regulated SNK induced decrease of SPAR and PSD-95, which ... even loss of dendritic spines in hippocampus by SNK-SPAR pathway, resulting in the cognitive impairments.
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2017 - Elsevier BV | Brain Research
Produção Nacional
de Assis Santos e Silva Francisco, Alberto Vieira de Azevedo Carlos,
... differences between the classifications of means of Tukey, SNK, Scott-Knott and Duncan tests, as well as ... to the tests of Duncan, Scott-Knott and SNK, but not very different, and it is the ... test. The tests of Duncan, Scott-Knott and SNK tend to show similar results, except for the ... than one group. The tests of Duncan and SNK, for being similar, except for the utilized distribution, ... Assistat, Tukey test, Duncan test, Scott-Knott test, SNK test.
Tópico(s): Wheat and Barley Genetics and Pathology
2016 - Academic Journals | African Journal of Agricultural Research
Eleftheria Hatzimichael, Aggeliki Dasoula, Leonidas Benetatos, Nelofer Syed, George Dranitsaris, Tim Crook, Konstantinos L. Bourantas,
... status of the CpG island of CDKN2A and Snk/Plk2 and MTHFR genotypes and with overall survival ( ... disease, anemia, and extramedullary disease. Regarding CDKN2A and Snk/Plk2 CpG island methylation analysis, we found 12 ... of 45, respectively, to be methylated. CDKN2A and Snk/Plk2 methylation did not correlate with MTHFR genotypes. Herein, we report the identification of Snk/Plk2 as a novel methylated gene in MM ... any, of MTHFR 1298 polymorphisms and CDKN2A and Snk/Plk2 methylation in the pathogenesis of MM.
Tópico(s): Genomic variations and chromosomal abnormalities
2010 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma