S. JONES, Azure L. Yarbrough, William E. Fantegrossi, Paul L. Prather, John M. Bush, Anna Radomińska‐Pandya, Ryoichi Fujiwara,
... 1‐(5‐fluoropentyl)‐1 H ‐indole‐3‐carboxamide (STS‐135) is a third generation SCB. When incubated with ... and glucuronidation, resulting in 29 metabolites, with monohydroxy STS‐135 (M25) and dihydroxy STS‐135 (M21) being the predominant metabolites. The enzymes responsible ... CYPs) enzymes involved in the oxidative metabolism of STS‐135. In this study, STS‐135 was incubated with liver, intestinal, and brain microsomes ... was carried out using ultra‐performance liquid chromatography. STS‐135 was extensively metabolized in HLMs and HIMs. Screening ...
Tópico(s): Forensic Toxicology and Drug Analysis
2020 - Wiley | Pharmacology Research & Perspectives
Adarsh Gandhi, Ariane Wohlfarth, Mingshe Zhu, Shaokun Pang, Marisol S. Castaneto, Karl B. Scheidweiler, Marilyn A. Huestis,
... 1‐(5‐fluoropentyl)‐1 H ‐indole‐3‐carboxamide (STS‐135) is a new synthetic cannabinoid in herbal incense ... in police seizures. To date, there are no STS‐135 clinical or in vitro studies identifying STS‐135 metabolites. However, characterizing STS‐135 metabolism is critical because synthetic cannabinoid metabolites can ... human hepatocytes were incubated with 10 µmol/L STS‐135 for up to 3 h. High‐resolution mass spectrometry with software‐assisted data mining identified 29 STS‐135 metabolites. Less than 25% of STS‐135 parent ...
Tópico(s): Alcohol Consumption and Health Effects
2014 - Wiley | Drug Testing and Analysis
Isabella Canazza, Andrea Ossato, Fabrizio Vincenzi, Adolfo Gregori, Fabiana Di Rosa, Federica Nigro, Alessandro Rimessi, Paolo Pinton, Katia Varani, Pier Andrea Borea, Matteo Marti,
Introduction 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 are 3 novel third‐generation fluorinate synthetic cannabinoids that are illegally marketed as incense, herbal preparations, or research chemicals for their psychoactive ... pharmacological activity of 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 in male CD‐1 mice, comparing their in ... potency of the 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 on mouse and human CB 1 and CB ... studies showed that 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 induced hypothermia; increased pain threshold to both noxious ...
Tópico(s): Forensic Toxicology and Drug Analysis
2017 - Wiley | Human Psychopharmacology Clinical and Experimental
Didem Dagdeviren, Žana Kalajzić, Douglas J. Adams, Ivo Kalajzić, Alan G. Lurie, Maija I. Mednieks, Arthur R. Hand,
... and incisors of mice flown on the US STS-135 space shuttle mission and the Russian Bion-M1 ... Incisor length was greater in the 13-day STS-135 flight mice than in either control group. Initial ... mice. Mandibular bone volume (BV) was increased in STS-135 flight and habitat groups and decreased in Bion- ... was greatest in flight mice, and greater in STS-135 flight and habitat control mice than in the ...
Tópico(s): Space Exploration and Technology
2018 - Elsevier BV | Archives of Oral Biology
Samuel D. Banister, Jordyn Stuart, Richard C. Kevin, Amelia R. Edington, Mitchell Longworth, Shane M. Wilkinson, Corinne Beinat, Alexandra S. Buchanan, David E. Hibbs, Michelle Glass, Mark Connor, Iain S. McGregor, Michael Kassiou,
... AM-2201, XLR-11, 5F-PB-22, and STS-135 at human CB1 and CB2 receptors using a ... 11, PB-22, 5F-PB-22, APICA, and STS-135 in vivo were evaluated in rats using biotelemetry. ... 5F-PB-22 = JWH-018 > AM-2201 > APICA = STS-135 = XLR-11 > UR-144).
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2015 - American Chemical Society | ACS Chemical Neuroscience
Payal Ghosh, John N. Stabley, Bradley J. Behnke, Matthew R. Allen, Michael D. Delp,
... Shuttle mission (n=8) and 13d on the STS-135 mission (n=5) or remained as ground controls ( ... GC mice for either the STS-131 or STS-135 missions. Mandibular BV/TV (combined cortical and trabecular ... 84.2±1.2%), whereas BV/TV from STS-135 mice was not different from GC animals (n= ... spaceflight, while CEJ-AC distance was similar between STS-135 and GC mice. These findings demonstrate that mandibular ...
Tópico(s): High Altitude and Hypoxia
2015 - Elsevier BV | Bone
Maria Antonietta De Luca, M. Paola Castelli, Barbara Loi, Alessandra Porcu, Mariella Martorelli, Cristina Miliano, Kathryn Kellett, Colin Davidson, Jacqueline L. Stair, Fabrizio Schifano, G. Di Chiara,
... 22, 5F-PB-22, 5F-AKB-48 and STS-135, their in vitro affinity and agonist potency at ... 2 nM; Emax, 163%). 5F-AKB-48 and STS-135 had higher Ki for CB1 binding, higher EC50 ... kg; 5F-AKB-48, 0.1 mg/kg; STS-135, 0.15 mg/kg i.v.). 3rd generation ...
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Elsevier BV | Neuropharmacology
Xiao Wen Mao, Michael J. Pecaut, Louis Stodieck, Virginia L. Ferguson, T. A. Bateman, M. L. Bouxsein, Daila S. Gridley,
... skin tissues were also characterized. Space Shuttle Atlantis (STS-135) was launched at the Kennedy Space Center on ... Female C57BL/6 mice were flown in the STS-135 using animal enclosure modules (AEMs). Within 3-5 ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2014 - Taylor & Francis | Free Radical Research
Sarah E. Latchney, Phillip D. Rivera, Xiao Wen Mao, Virginia L. Ferguson, Ted A. Bateman, Louis Stodieck, Gregory A. Nelson, Amelia J. Eisch,
... flight on Space Shuttle Atlantis [Space Transport System (STS)-135] relative to two groups of control mice maintained ... animal enclosure modules that mimicked the conditions onboard STS-135 (AEM-Ground mice) had greater OB volume relative ... OB volume and neurogenesis was not seen in STS-135 mice (AEM-Flight mice), suggesting that spaceflight may ...
Tópico(s): Circadian rhythm and melatonin
2014 - American Physiological Society | Journal of Applied Physiology
Didem Dagdeviren, John Beallias, Izaz Ahmad Khan, Maija I. Mednieks, Arthur R. Hand,
... Discovery [Space Transportation System ( STS )‐131] and Atlantis ( STS ‐135). No differences in mucous acinar or serous demilune ... compared with ground (control) mice but decreased in STS ‐135 flight mice. Similarly, expression of mucin ( MUC ‐19) ... in STS ‐131 flight mice and decreased in STS ‐135 flight mice, but not significantly. Demilune cell and ...
Tópico(s): Salivary Gland Disorders and Functions
2018 - Wiley | European Journal Of Oral Sciences
Anaam Ameen, Kelly Brown, Lynn Dennany,
... we investigate the impact of combining two SC, STS-135 and BB-22 into a single matrix to ...
Tópico(s): Psychedelics and Drug Studies
2022 - Elsevier BV | Journal of Electroanalytical Chemistry
Shen‐An Hwang, Brian Crucian, Clarence F. Sams, Jeffrey K. Actor,
... monocyte changes post 13 days orbital flight (mission STS-135). Analysis includes an examination in surface markers for ...
Tópico(s): Medical and Biological Ozone Research
2015 - Public Library of Science | PLoS ONE
Corey A. Theriot, Susana B. Zanello,
... collected from male C57BL/6 mice flown on STS-135 (FLT) on landing day or from their ground ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2014 - De Gruyter | Gravitational and Space Research
Maija I. Mednieks, Aditi Khatri, Arthur R. Hand,
... biochemical/molecular methods were employed. Acinar cells of STS-135 (13 day) and Bion-M1 (30 day) flight ... duct cells contained vacuoles with endocytosed proteins. In STS-135, decreases were seen in the regulatory subunit of ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2015 - De Gruyter | Gravitational and Space Research
... foreground extraction method on infrared images from the STS-135 flight mission captured by the space shuttle's ...
Tópico(s): Space Satellite Systems and Control
2021 - American Institute of Aeronautics and Astronautics | Journal of Spacecraft and Rockets
Michelle D. Williams, Jennifer Martin, Peter Galettis,
... PINACA, AB-CHMINACA, AM2201, RCS-4, JWH-250, STS-135, JWH-73, XLR-11, JWH-251, JWH-18, ...
Tópico(s): Alcohol Consumption and Health Effects
2018 - Oxford University Press | Journal of Analytical Toxicology
Xiao Wen Mao, Lawrence B. Sandberg, Daila S. Gridley, Eric Herrmann, Guangyu Zhang, Ravi Raghavan, Roman A. Zubarev, Bo Zhang, Louis Stodieck, Virginia L. Ferguson, Ted A. Bateman, Michael J. Pecaut,
... in mouse brain were characterized. Space Shuttle Atlantis (STS-135) was launched from the Kennedy Space Center (KSC) ...
Tópico(s): Anesthesia and Neurotoxicity Research
2018 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Hua Shen, Chanteak Lim, Andrea G. Schwartz, Alexander Andreev‐Andrievskiy, Alix Deymier, Stavros Thomopoulos,
... d Space Transportation System (STS)-131, 13-d STS-135, and 30-d Bion-M1 missions. Mice from ...
Tópico(s): Muscle metabolism and nutrition
2017 - Wiley | The FASEB Journal
Michael J. Pecaut, Xiao Wen Mao, Denise L. Bellinger, Karen R. Jonscher, Louis Stodieck, Virginia L. Ferguson, Ted A. Bateman, Robert P. Mohney, Daila S. Gridley,
... Space Shuttle Atlantis launched on its final mission (STS-135) on July 8, 2011. After just under 13 ...
Tópico(s): Adipose Tissue and Metabolism
2017 - Public Library of Science | PLoS ONE
Mitchell Longworth, Mark Connor, Samuel D. Banister, Michael Kassiou,
Synthetic cannabinoids (SCs) containing a 1-pentyl-1-H substituted indole or indazole are abused around the world and are associated with an array of serious side effects. These compounds undergo extensive phase 1 metabolism after ingestion with little understanding whether these metabolites are contributing to the cannabimimetic activity of the drugs. This work presents the synthesis and pharmacological characterization of the major metabolites of two high concern SCs; APICA and ADB-PINACA. In a ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2017 - American Chemical Society | ACS Chemical Neuroscience
Willard J. Costain, Joseph S. Tauskela, Ingrid Rasquinha, Tanya Comas, Melissa Hewitt, Vincent Marleau, Evelyn C. Soo,
... 250≈ PB-22>AKB48 N-(5FP)>AKB-48≈STS-135>XLR-11. Assessment of agonist-stimulated depression of ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2016 - Elsevier BV | European Journal of Pharmacology
Loretta Ford, Jonathan D Berg,
... 48 and N-adamantyl-1-fluoropentylindole-3-carboxamide (STS-135). Out of 18 potential metabolites, 1-adamantylamine (C10H17N) ...
Tópico(s): Alcohol Consumption and Health Effects
2016 - SAGE Publishing | Annals of Clinical Biochemistry International Journal of Laboratory Medicine
Pavlina Andreeva-Gateva, Vasilka H. Nankova, Violina T. Angelova, Tzvetelin N. Gatev,
... was: UR-144 + MAM-2201 with or without STS-135. Highly potent halogenated SCs appeared in 2013. 5F- ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2015 - Elsevier BV | Drug and Alcohol Dependence
Nabarun Chakraborty, Aarti Gautam, Seid Muhie, Stacy‐Ann Miller, Marti Jett, Rasha Hammamieh,
... LPS). The assay was carried out onboard the STS-135 spaceflight, and a concurrent ground study constituted the ...
Tópico(s): High Altitude and Hypoxia
2014 - BioMed Central | BMC Genomics
Takashi Ashino, Kanae Hakukawa, Yuka Itoh, Satoshi Numazawa,
... effects were weaker than naphthoylindole. An adamantylamidoindole derivative, STS-135, showed inhibition of CYP1A activity in a concentrationdependent ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2014 - Japanese Society of Toxicological Sciences | The Journal of Toxicological Sciences
Tim Sobolevsky, Ilya Prasolov, Г. М. Родченков,
... fluoropentyl)‐1 H ‐indole‐3‐carboxamide (5F‐APICA, STS‐135), which are active ingredients of smoking mixtures sold ...
Tópico(s): Cannabis and Cannabinoid Research
2014 - Wiley | Drug Testing and Analysis
Xiao Wen Mao, Michael J. Pecaut, Louis Stodieck, Virginia L. Ferguson, Ted A. Bateman, Mary Bouxsein, Tamako Jones, Maria Moldovan, Christopher E. Cunningham, Jenny Chieu, Daila S. Gridley,
... mice were flown in the space shuttle Atlantis (STS-135), and within 3-5 h of landing, the ...
Tópico(s): Corneal surgery and disorders
2013 - Radiation Research Society | Radiation Research
Wooseong Kim, Farah K. Tengra, Zachary D. Young, Jasmine Shong, Nicholas Marchand, Hon Kit Chan, Ravindra C. Pangule, Macarena Parra, Jonathan S. Dordick, Joel L. Plawsky, Cynthia H. Collins,
... two Space Shuttle Atlantis missions: STS-132 and STS-135, and the biofilms formed during spaceflight were characterized. ...
Tópico(s): Space Exploration and Technology
2013 - Public Library of Science | PLoS ONE
Curtis R. Taylor, Mina Hanna, Bradley J. Behnke, John N. Stabley, Danielle J. McCullough, Robert T. Davis, Payal Ghosh, Anthony Papadopoulos, Judy M. Muller‐Delp, Michael D. Delp,
... that 13 d of spaceflight [Space Transportation System (STS)-135 shuttle mission] enhances myogenic vasoconstriction, increases medial wall ...
Tópico(s): High Altitude and Hypoxia
2013 - Wiley | The FASEB Journal
Daila S. Gridley, Xiao Wen Mao, Louis Stodieck, Virginia L. Ferguson, Ted A. Bateman, Maria Moldovan, Christopher E. Cunningham, Tamako Jones, Jerry M. Slater, Michael J. Pecaut,
[This corrects the article on p. e75097 in vol. 8.].
Tópico(s): High Altitude and Hypoxia
2013 - Public Library of Science | PLoS ONE