... two glucose receptors in the yeast Saccharomyces cerevisiae Sabire Özcan Sabire Özcan Present address: Department of Cell Biology and ... USA Search for more papers by this author Sabire Özcan Sabire Özcan Present address: Department of Cell Biology and ... for more papers by this author Author Information Sabire Özcan2, Jim Dover1 and Mark Johnston 1 1Department ...
Tópico(s): Plant nutrient uptake and metabolism
1998 - Springer Nature | The EMBO Journal
Zafer Kurugöl, Ferda Özkınay, Fadıl Vardar, Sabire Karaçalı, Necil Kütükçüler, Remziye Deveci,
... andSearch for more papers by this authorSabire Karaçali, Sabire Karaçali Department of Molecular Biology, Ege University Faculty ... andSearch for more papers by this authorSabire Karaçali, Sabire Karaçali Department of Molecular Biology, Ege University Faculty ...
Tópico(s): Research on Leishmaniasis Studies
2001 - Wiley | Pediatrics International
Sırmahan Çakarer, Fırat Selvi, Sabire Işler, Merva Soluk, Vakur Olgaç, Cengizhan Keskin,
Intraosseous lipoma is a benign tumor of the bone. It is mostly seen in the metaphyses of the long bones and calcaneus. There are few documented cases of intraosseous lipomas in the jaw. Clinically, the lesion is usually silent and radiologically it appears as a radiolucent area rarely including some radio-opacities. Diagnosis is based on clinical, radiological and histopathological features. Surgical removal of the lesion is the recommended treatment. The authors report a rare case of an intraosseous ...
Tópico(s): Oral and Maxillofacial Pathology
2009 - Elsevier BV | International Journal of Oral and Maxillofacial Surgery
AbstractSmall, noncoding ribonucleotides called micro RNAs (miRNAs) have recently emerged as important regulators of cell function. MiRNAs regulate gene expression mainly by binding to the 3' UTR of mRNAs and thereby inhibit the translation of target mRNAs. The abundance of many miRNAs is altered under physiological and pathophysiological conditions, such as cancer and neurodegeneration. Recent data suggest that miRNAs also have an important role in regulation of insulin gene transcription, insulin ...
Tópico(s): MicroRNA in disease regulation
2009 - Taylor & Francis | Islets
Tuğba Karakoç, Sabire Yurtsever,
This descriptive study was conducted with the purpose of determining the relationship between fatigue and social support in elderly individuals receiving chemotherapy.It was conducted in the oncology outpatient chemotherapy units of two university hospitals and one research hospital. A total of 71 patients who were 60 years old and older and receiving outpatient chemotherapy were included. Data were collected using a "Personal Information Form," "Social Support Scale in Cancer Patients," and "Visual ...
Tópico(s): Cancer-related cognitive impairment studies
2009 - Elsevier BV | European Journal of Oncology Nursing
Sabire �zcan, Peter K�tter, Michael Ciciary,
Tópico(s): Fungal and yeast genetics research
1991 - Springer Science+Business Media | Applied Microbiology and Biotechnology
In addition to being the universal carbon and energy source, glucose also regulates gene expression in many organisms. In the yeast Saccharomyces cerevisiae glucose regulates gene expression via two different pathways known as the glucose repression and glucose induction pathways. The signal for glucose induction of hexose transporter (HXT) genes is generated via two glucose-transporter like molecules, Snf3 and Rgt2. A strain lacking both sensors is unable to induce HXT gene expression and is defective ...
Tópico(s): Plant Gene Expression Analysis
2002 - Elsevier BV | Journal of Biological Chemistry
Jaganathan Lakshmanan, Amber L. Mosley, Sabire �zcan,
Tópico(s): Genomics and Chromatin Dynamics
2003 - Springer Science+Business Media | Current Genetics
Amber L. Mosley, Sabire Özcan,
Induction of insulin gene expression in response to high blood glucose levels is essential for maintaining glucose homeostasis. Although several transcription factors including Beta-2, Ribe3b1, and Pdx-1 have been shown to play a role in glucose stimulation of insulin gene expression, the exact molecular mechanism(s) by which this regulation occurs is unknown. Previous data demonstrate that the transcription factors Beta-2/NeuroD1 and Pdx-1, which are involved in glucose-stimulated insulin gene ...
Tópico(s): Epigenetics and DNA Methylation
2003 - Elsevier BV | Journal of Biological Chemistry
Hikmet Hakan Aydın, Hakan Kültürsay, Remziye Deveci, Ender Terzıoğlu, Sabire Karaçalı, Nihal Mete, Ulus Salih Akarca, Yücel Batur,
Tópico(s): Immunotoxicology and immune responses
2003 - Springer Science+Business Media | Biological Trace Element Research
Amber L. Mosley, Jaganathan Lakshmanan, Bishwa K. Aryal, Sabire Özcan,
Glucose, the most abundant carbon and energy source, regulates the expression of genes required for its own efficient metabolism. In the yeast Saccharomyces cerevisiae, glucose induces the expression of the hexose transporter (HXT) genes by modulating the activity of the transcription factor Rgt1 that functions as a repressor when glucose is absent. However, in the presence of high concentrations of glucose, Rgt1 is converted from a repressor to an activator and is required for maximal induction ...
Tópico(s): Biofuel production and bioconversion
2003 - Elsevier BV | Journal of Biological Chemistry
Sabire Özcan, Frank Schulte, Kerstin Freidel, Andrea Weber, Michael Ciriacy,
Glucose repression in the yeast Saccharomyces cerevisiae designates a global regulatory system controlling the expression of various sets of genes required for the utilization of alternate carbon sources. In a screen, designed for the selection of mutants with reduced glycolytic flux we obtained isolates which were shown by complementation of the cloned wild‐type gene to be allelic to the glucose repression mutants grr1/cat80/cot2 previously described. We demonstrate that the grrl lesion lead to ...
Tópico(s): Bacterial Genetics and Biotechnology
1994 - Wiley | European Journal of Biochemistry
Xiaohu Tang, Guiliang Tang, Sabire Özcan,
Diabetes is one of the most common chronic diseases in the world. Multiple and complex factors including various genetic and physiological changes can lead to type 1 and type 2 diabetes. However, the major mechanisms underlying the pathogenesis of diabetes remain obscure. With the recent discovery of microRNAs (miRNAs), these small ribonucleotides have been implicated as new players in the pathogenesis of diabetes and diabetes-associated complications. MiRNAs have been shown to regulate insulin production, ...
Tópico(s): Circular RNAs in diseases
2008 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Shuangli Guo, Ryan N. Burnette, Li Zhao, Nathan L. Vanderford, Vincent Poitout, Derek Hagman, Eva Henderson, Sabire Özcan, Brian E. Wadzinski, Roland Stein,
The level of the MafA transcription factor is regulated by a variety of effectors of β cell function, including glucose, fatty acids, and insulin. Here, we show that phosphorylation at Ser65 of mammalian MafA influences both protein stability and transactivation potential. Replacement of Ser65 with Glu to mimic phosphorylation produced a protein that was as unstable as the wild type, whereas Asp or Ala mutation blocked degradation. Analysis of MafA chimeric and deletion constructs suggests that ...
Tópico(s): Metabolism, Diabetes, and Cancer
2008 - Elsevier BV | Journal of Biological Chemistry
Sreenath S. Andrali, Megan L. Sampley, Nathan L. Vanderford, Sabire Özcan,
Production and secretion of insulin from the β-cells of the pancreas is very crucial in maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and exocytosis from the β-cells in response to changes in blood glucose levels. The synthesis of insulin is regulated by blood glucose levels at the transcriptional and post-transcriptional levels. Although many transcription factors have been implicated in the regulation of insulin gene transcription, three β-cell-specific ...
Tópico(s): Diabetes and associated disorders
2008 - Portland Press | Biochemical Journal
Serap Sayar, Sibel Turgut, Havva Doğan, Aynur Ekici, Sabire Yurtsever, Ferit Demirkan, Nurcan Doruk, Bahar Taşdelen,
To determine incidence of pressure ulcers in patients at risk according to the Waterlow scale in intensive care units and to evaluate the effects of risk factors in critically ill patients.Pressure ulcers continue to be an important health problem that increases the risk of illness and death, extends patients' length of hospital stay and increases healthcare expenses.The study was conducted as a descriptive and prospective study.The sample consisted of 140 patients. Data were collected using a data ...
Tópico(s): Diagnosis and Treatment of Venous Diseases
2008 - Wiley | Journal of Clinical Nursing
Nathan L. Vanderford, Jamie E.L. Cantrell, Gabriel J. Popa, Sabire Özcan,
MafA is a basic leucine zipper transcription factor expressed within the beta cells of the pancreas and is required to maintain normal glucose homeostasis as it is involved in various aspects of beta cell biology. MafA protein levels are known to increase in response to high glucose through mechanisms that have yet to be fully characterized. We investigated whether discrete intracellular signaling events control mafA expression. We found that the general kinase inhibitor staurosporine induces mafA ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2008 - Elsevier BV | Archives of Biochemistry and Biophysics
Xiaoqing Tang, Latha Muniappan, Guiliang Tang, Sabire Özcan,
MicroRNAs (miRNAs) are small noncoding ribonucleotides that bind mRNAs and function mainly as translational repressors in mammals. MicroRNAs have been implicated to play a role in many diseases, including diabetes. Several reports indicate an important function for miRNAs in insulin production as well as insulin secretion. We have recently carried out a screen in the pancreatic β-cell line MIN6 to identify miRNAs with altered abundance in response to changes in glucose concentrations. This screen ...
Tópico(s): RNA modifications and cancer
2008 - Cold Spring Harbor Laboratory Press | RNA
Cemile Kütmeç, Sabire Yurtsever,
Hypertension, one of the increasingly common chronic diseases, is reported to be an important factor in the formation of sexual dysfunction (SD) due to the physiopathological changes it creates in the vascular endothelial structure. The evaluation of the sexual functions of hypertensive women is regarded as a significant consideration in the improvement of women's health and quality of life.This study was carried out in order to identify the sexual functions of essential hypertensive women.The study ...
Tópico(s): Female Genital Mutilation/Cutting Issues
2010 - Oxford University Press | European Journal of Cardiovascular Nursing
Sabire Özcan, Sreenath S. Andrali, Jamie E.L. Cantrell,
O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of nuclear and cytoplasmic proteins is important for many cellular processes, and the number of proteins that contain this modification is steadily increasing. This modification is dynamic and reversible, and in some cases competes for phosphorylation of the same residues. O-GlcNAc modification of proteins is regulated by cell cycle, nutrient metabolism, and other extracellular signals. Compared to protein phosphorylation, which is mediated ...
Tópico(s): Ubiquitin and proteasome pathways
2010 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Latha Muniappan, Sabire Özcan,
Type 1 Diabetes Mellitus results from an autoimmune destruction of the pancreatic beta cells, which produce insulin. The lack of insulin leads to chronic hyperglycemia and secondary complications, such as cardiovascular disease. The currently approved clinical treatments for diabetes mellitus often fail to achieve sustained and optimal glycemic control. Therefore, there is a great interest in the development of surrogate beta cells as a treatment for type 1 diabetes. Normally, pancreatic beta cells ...
Tópico(s): Diabetes Management and Research
2007 - Springer Science+Business Media | BMC Physiology
Sreenath S. Andrali, Qingwen Qian, Sabire Özcan,
O-Linked GlcNAc modification of nuclear and cytosolic proteins has been shown to regulate the function of many cellular proteins. Increased O-linked glycosylation, observed under chronic hyperglycemia conditions, has been implicated in the pathogenesis of diabetes. However, the exact role of O-GlcNAc modification in regulating glucose homeostasis remains to be established. We report here that the subcellular localization of the pancreatic beta cell-specific transcription factor NeuroD1 is regulated ...
Tópico(s): Signaling Pathways in Disease
2007 - Elsevier BV | Journal of Biological Chemistry
PURPOSE. This study was designed to determine the difficulties experienced by families with disabled children. DESIGN AND METHOD. This descriptive research study was carried out in one public and two private rehabilitation centers. A questionnaire was used for data collection. RESULTS. Families did not have enough knowledge about their child's condition. Mothers felt severe sadness, and they indicated that after having a disabled child, their social life, working life, and family relationships were ...
Tópico(s): Cerebral Palsy and Movement Disorders
2007 - Wiley | Journal for Specialists in Pediatric Nursing
Megan L. Sampley, Sabire Özcan,
Glucose-stimulated insulin gene transcription is mainly regulated by a 340-bp promoter region upstream of the transcription start site by beta-cell-enriched transcription factors Pdx-1, MafA, and NeuroD1. Previous studies have shown that histone H4 hyperacetylation is important for acute up-regulation of insulin gene transcription. Until now, only the histone acetyltransferase (HAT) protein p300 has been shown to be involved in this histone H4 acetylation event. In this report we investigated the ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2011 - Mary Ann Liebert, Inc. | DNA and Cell Biology
Özlem Canpolat, Sabire Yurtsever,
PurposeThis study aims to evaluate the quality of life (QoL) in patients with Behçet's disease.MethodsThis study is a cross-sectional descriptive study. The sample of the study consists of 94 volunteer patients, who were diagnosed with Behçet's disease at least 3 months before the study, were literate, and never diagnosed with a psychiatric illness. Short Form-36 QoL Scale and personal information form were used to collect data. The mean, percentage distribution of the sample were calculated; one- ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2011 - Elsevier BV | Asian Nursing Research
Nathan L. Vanderford, Sreenath S. Andrali, Sabire Özcan,
MafA is a basic leucine zipper transcription factor that regulates gene expression in both the neuroretina and pancreas. Within the pancreas, MafA is exclusively expressed in the beta cells and is involved in insulin gene transcription, insulin secretion, and beta cell survival. The expression of the mafA gene within beta cells is known to increase in response to high glucose levels by an unknown mechanism. In this study, we demonstrate that pyruvate, which is produced by glycolysis from glucose, ...
Tópico(s): Pancreatitis Pathology and Treatment
2006 - Elsevier BV | Journal of Biological Chemistry
Pia März, Jörg Stetefeld, Kerstin Bendfeldt, Cordula Nitsch, Jochen Reinstein, Robert L. Shoeman, Beatrice Dimitriades‐Schmutz, Martine Schwager, Dominic Leiser, Sabire Özcan, U. Otten, Suat Özbek,
Modification by O-GlcNAc involves a growing number of eucaryotic nuclear and cytosolic proteins. Glycosylation of intracellular proteins is a dynamic process that in several cases competes with and acts as a reciprocal modification system to phosphorylation. O-Linked beta-N-acetylglucosamine transferase (OGT) levels are highest in the brain, and neurodegenerative disorders such as Alzheimer disease have been shown to involve abnormally phosphorylated key proteins, probably as a result of hypoglycosylation. ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2006 - Elsevier BV | Journal of Biological Chemistry
Fırat Selvi, Merva Soluk Tekkeşin, Sırmahan Çakarer, Sabire Işler, Cengizhan Keskin,
The purpose of the present study was to investigate the possible role of Ki-67 and argyrophilic nucleolar organizing regions (AgNOR) between the recurrent and nonrecurrent keratocystic odontogenic tumors (KCOTs). Another aim was to compare the correlation between these two markers.22 KCOTs were evaluated retrospectively. The actual proliferative activity of the KCOT was measured by Ki-67 labelling index and argyrophilic nucleolar organizing regions AgNOR count per nucleus.Recurrence occurred in 3 ...
Tópico(s): Head and Neck Surgical Oncology
2012 - Ivyspring International Publisher | International Journal of Medical Sciences
Özlem Oral, Devrim Öz Arslan, Zeynep Itah, Atabak Naghavi, Remziye Deveci, Sabire Karaçalı, Devrim Gözüaçık,
Tópico(s): CRISPR and Genetic Engineering
2012 - Springer Science+Business Media | APOPTOSIS
Jamie C. Stanford, Andrew J. Morris, Manjula Sunkara, Gabriel J. Popa, Kara Larson, Sabire Özcan,
Recent studies suggest that sphingolipid metabolism is altered during type 2 diabetes. Increased levels of the sphingolipid ceramide are associated with insulin resistance. However, a role for sphingolipids in pancreatic beta cell function, or insulin production, and release remains to be established. Our studies in MIN6 cells and mouse pancreatic islets demonstrate that glucose stimulates an intracellular rise in the sphingolipid, sphingosine 1-phosphate (S1P), whereas the levels of ceramide and ...
Tópico(s): Erythrocyte Function and Pathophysiology
2012 - Elsevier BV | Journal of Biological Chemistry