Kaoru Kobayashi, Saeko Yamagami, Tomoaki Higuchi, Masakiyo Hosokawa, Kan Chiba,
The ligand-binding domain of human pregnane X receptor (hPXR) is highly hydrophobic and flexible, allowing promiscuity in accepting structurally diverse ligands. However, little information is available regarding the critical substituents of compounds involved in the activation of hPXR. The aim of this study was to determine the structure-activity relationships for hPXR-mediated transactivation by barbiturates, hydantoins, and macrolide antibiotics. Most of the barbiturates studied (mephobarbital, ...
Tópico(s): Estrogen and related hormone effects
2004 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Keito Koh, Keiko Yamada, Tatsuya Enomoto, Aiko Kawai, Saeko Hamaoka, Satoko Chiba, Masako Iseki,
Purpose . Pain experience due to spinal degenerative disease decreases activity of daily living and quality of life. The present cross-sectional study was aimed at examining the sex-specific impact of pain severity, psychosocial factors, and insomnia on the disability due to chronic pain arising from spinal degenerative disease. Methods . In total, 111 outpatients with chronic spinal degenerative on initial diagnosis were analyzed. The definition of chronic spinal degenerative disease was (1) pain duration ≥ ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2020 - Hindawi Publishing Corporation | Pain Research and Management
Tetsuo No, Takahiro Hiramatsu, Takeshi Sato, Seiichi Miura, Tatsuro Chiba, Saeko Kamiyama, Iki Shinji, Shuichi Kodaira,
近年，海洋研究開発機構は多くの地震探査航海を日本海で実施し，その探査中マルチビームによる高品質な海底地形データを同時に取得している．海底地形はその海域におけるテクトニクスや構造発達史を解明する手かがりの1つであり，地震研究においても，例えば震源断層のパラメータの検討の観点から重要である．したがって，高品質な海底地形データを活用することができれば，断層の長さに関する検討の精度が上がり，震源断層の大きさの議論の進展にもつながる．その結果，日本海における地震活動・活構造と地殻構造の関係をより統合的に研究を推進することができる．本報告では，地震探査時に取得された海底地形データを加えた日本海全域及びその周辺の地形データを用いて，それらを統合したDEM（数値標高モデル:Digital Elevation Model）データを作り，さらにそのデータを用いて方向依存性のない立体感が得られる赤色立体地図を作製した結果について記す．
Tópico(s): Seismic Waves and Analysis
2016 - | JAMSTEC Report of Research and Development
Yu Funakoshi, Kenta Ito, Saeko Morino, Kazue Kinoshita, Yoshihiko Morikawa, Tatsuo Kono, Yen Hai Doan, Hiroyuki Shimizu, Nozomu Hanaoka, Masami Konagaya, Tsuguto Fujimoto, Ai Suzuki, Takashi Chiba, Tetsuya AKIBA, Yasuhiro Tomaru, Ken Watanabe, Norio Shimizu, Yuho Horikoshi,
Abstract Background Outbreaks of enterovirus D68 ( EV ‐D68) respiratory infections in children were reported globally in 2014. In Japan, there was an EV ‐D68 outbreak in the autumn of 2015 (September–October). The aim of this study was to compare EV ‐D68‐specific polymerase chain reaction ( PCR )‐positive and EV ‐D68‐specific PCR ‐negative patients. Methods Pediatric patients admitted for any respiratory symptoms between September and October 2015 were enrolled. Nasopharyngeal swabs were tested for multiplex ...
Tópico(s): Viral gastroenteritis research and epidemiology
2019 - Wiley | Pediatrics International
Miu Okubo, Risako Chiba, Takeo Karakida, Hajime Yamazaki, Ryûji Yamamoto, Saeko Kobayashi, Takahiko Niwa, H.C. Margolis, Takatoshi Nagano, Yasuo Yamakoshi, Kazuhiro Gomi,
To investigate potential functions of transforming growth factor-beta (TGF-β) isoforms in maturation-stage ameloblasts during amelogenesis. In vivo activation of TGF-β was characterized by using matrix metalloproteinase 20 null (Mmp20-/-) and wild-type (Mmp20+/+) mice. Using mHAT9d cells cultured in the presence of each TGF-β isoform, (1) cell proliferation was determined by MTS assay, (2) immunostaining with anti-cleaved caspase-3 monoclonal antibody was performed and apoptotic indices were measured, ( ...
Tópico(s): Bone and Dental Protein Studies
2019 - Elsevier BV | Journal of Oral Biosciences
Haru Kato, Mitsutoshi Senoh, Hitoshi Honda, Tadashi Fukuda, Yasuaki Tagashira, Hiroko Horiuchi, Hiroshi Chiba, Daisuke Suzuki, Naoto Hosokawa, Hidetaka Kitazono, Yasuhiro Norisue, Kume Hisashi, N. Môri, H. Morikawa, Saeko Kashiwagura, Akiko Higuchi, Hideaki Kato, Makoto Nakamura, Saori Ishiguro, Sayuri Morita, Hideaki Ishikawa, Takuya Watanabe, Katsuyuki Kojima, Yokomaku Izumi, Tatsuya Bando, Toimoto Kayoko, Kei Moriya, Kei Kasahara, Seigo Kitada, Junko Ogawa, Haruko Saito, Harumi Tominaga, Yousuke Shimizu, Fumi Masumoto, Kayoko Tadera, Junichi Yoshida, Tetsuya Kikuchi, Ichiro Yoshikawa, Tatsuyuki Watanabe, Masahisa Honda, Yokote Kuniko, Takao Toyokawa, Hiroko Miyazato, Mika Nakama, Cédric Mahé, Kimberly A. Reske, Margaret A. Olsen, Erik R. Dubberke,
Clostridioides (Clostridium) difficile is the leading cause of healthcare-associated infectious diarrhea in the developed world. Retrospective studies have shown a lower incidence of C. difficile infection (CDI) in Japan than in Europe or North America. Prospective studies are needed to determine if this is due lack of testing for C. difficile or a true difference in CDI epidemiology. A prospective cohort study of CDI was conducted from May 2014 to May 2015 at 12 medical facilities (20 wards) in Japan. ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2019 - Elsevier BV | Anaerobe
Ho Lee, Shotaro Chubachi, Ho Namkoong, Takanori Asakura, Hiromu Tanaka, Shiro Otake, Kensuke Nakagawara, Atsuho Morita, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai∥, Koichi Fukunaga, Ho Lee, Shotaro Chubachi, Ho Namkoong, Takanori Asakura, Hiromu Tanaka, Shiro Otake, Kensuke Nakagawara, Atsuho Morita, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai∥, Koichi Fukunaga, Kazuhisa Takahashi, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Ryousuke Aoki, Ai Nakamura, Sonoko Harada, Hitoshi Sasano, Katsunori Masaki, Shinnosuke Ikemura, Satoshi Okamori, Hideki Terai, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Yohei Mikami, Sho Uchida, Shunsuke Uno, Rino Ishihara, Yuta Matsubara, Tomoyasu Nishimura, Takunori Ogawa, Toshiro Sato, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Etsuko Tagaya, Masatoshi Kawana, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takanori Hasegawa, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Masumi Ai, Ken Hiroyuki OhtaKokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Sohei Nakayama, Keita Masuzawa, Tomomi Takano, Kazuhiko Katayama, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Ryuya Edahiro, Yuya Shirai, Kyuto Sonehara, Tatsuhiko Naito, Kenichi Yamamoto, Shinichi Namba, Ken Suzuki, Takayuki Shiroyama, Yuichi Maeda, Takuro Nii, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Noa Sasa, Shuhei Yamada, Toshihiro Kishikawa, Kazunori Tomono, Kazuto Kato Shuhei Yamada, Yuya Ueno, Motoyuki Suzuki, Norihiko Takemoto, Hirotaka Eguchi, Takahito Fukusumi, Takao Imai, Munehisa Fukushima, Masatoshi Takagaki, Haruhiko Kishima, Hidenori Inohara, Haruhiko Hirata, Yoshito Takeda, Atsushi Kumanogoh, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, J. Suzuki, Hiroki Nakatsumi, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Kazuyoshi Watanabe, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Hisako Sageshima, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, N. Môri, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Kodai Kawamura,
We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant.We used secondary data from a database and performed a retrospective cohort study that included 3261 patients aged ≥ 18 years enrolled from 78 hospitals that participated in the Japan COVID-19 Task Force between February 2020 and September 2021.Patients hospitalized during the second (mean age, ...
BioMed Central
Aiko Kawai, Keiko Yamada, Saeko Hamaoka, Satoko Chiba, Kentaro Wakaizumi, Keisuke Yamaguchi, Masako Iseki,
Cluster analysis can classify patients with chronic pain using multiple scales, and classification of chronic pain will be adopted in the International Classification of Diseases 11th revision (ICD–11) in 2022. In the present study, we aimed to investigate whether cluster analysis was practical for classifying chronic pain and to determine the association between these two classifications for chronic pain. This study included 229 patients with chronic pain who completed a self–reported questionnaire ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2020 - | PAIN RESEARCH
Risako Chiba, Miu Okubo, Ryûji Yamamoto, Mari M. Saito, Saeko Kobayashi, Elia Beniash, Yasuo Yamakoshi,
To provide in vivo biochemical evidence for the isolation, identification, and characterization of porcine keratin 75 (K75) in developing enamel.Immunolocalization of K75 was observed in mandibles from mice at postnatal days 5 and 11. K75 gene expression was analyzed by quantitative reverse transcription-polymerase chain reaction using enamel organ epithelium (EOE) of incisors from pigs at 5 months of age. Enamel protein was extracted and isolated from both immature and mature enamel of second molars ...
Tópico(s): Silk-based biomaterials and applications
2019 - Elsevier BV | Journal of Oral Biosciences
Mitsutoshi Senoh, Haru Kato, Hitoshi Honda, Tadashi Fukuda, Yasuaki Tagashira, Hiroko Horiuchi, Hiroshi Chiba, Daisuke Suzuki, Naoto Hosokawa, Hidetaka Kitazono, Yasuhiro Norisue, Kume Hisashi, N. Môri, H. Morikawa, Saeko Kashiwagura, Akiko Higuchi, Hideaki Kato, Makoto Nakamura, Saori Ishiguro, Sayuri Morita, Hideaki Ishikawa, Takuya Watanabe, Katsuyuki Kojima, Yokomaku Izumi, Tatsuya Bando, Toimoto Kayoko, Kei Moriya, Kei Kasahara, Seigo Kitada, Junko Ogawa, Haruko Saito, Harumi Tominaga, Yousuke Shimizu, Fumi Masumoto, Kayoko Tadera, Junichi Yoshida, Tetsuya Kikuchi, Ichiro Yoshikawa, Tatsuyuki Watanabe, Masahisa Honda, Yokote Kuniko, Takao Toyokawa, Hiroko Miyazato, Mika Nakama, Cédric Mahé, Kimberly A. Reske, Margaret A. Olsen, Erik R. Dubberke,
The optimal and practical laboratory diagnostic approach for detection of Clostridioides difficile to aid in the diagnosis of C. difficile infection (CDI) is controversial. A two-step algorithm with initial detection of glutamate dehydrogenase (GDH) or nucleic acid amplification test (NAAT) alone are recommended as a predominant method for C. difficile detection in developed countries. The aim of this study was to compare the performance of enzyme immunoassays (EIA) detecting toxins A and B, NAAT detecting ...
Tópico(s): Nosocomial Infections in ICU
2019 - Elsevier BV | Anaerobe
Yasuyoshi Chiba, Saeko Nakabayashi, H. Isosaka, Akihiko Uchiyama, Hirohiko Kimura, Toshiki Kawamoto,
Tópico(s): Digital Radiography and Breast Imaging
1992 - Japan Radiological Society | Japanese Journal of Radiological Technology
Aiko Kawai, Keiko Yamada, Satoko Chiba, Saeko Hamaoka, Keisuke Yamaguchi, Masako Iseki,
The aim of this study was to investigate the most important aspects of patient–reported outcome measures (PROMs) for pain assessment and their predictive value in treatment response. We analyzed 367 patients with acute–to–chronic pain (age: ≥ 20 years) who visited the pain clinic of a university hospital for the first time and responded to nine PROMs related to pain symptoms. Principal component analysis (PCA) was applied to the PROMs data, deriving principal components with their component scores (i. ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2024 - | PAIN RESEARCH
Takuya Matsushita, Katsuhisa Masaki, Jun‐ichi Kira,
... multiple sclerosis Hiroki Masuda, Masahiro Mori, Akiyuki Uzawa, Saeko Masuda, Mayumi Muto, Tomohiko Uchida, Satoshi Kuwabara (Department of Neurology, Graduate School of Medicine, Chiba University, Japan) 13. (P-5) Clinical phenotype of ...
Tópico(s): Macrophage Migration Inhibitory Factor
2014 - Wiley | Clinical and Experimental Neuroimmunology
Masako Iseki, Keisuke Yamaguchi, Atsuko Hara, Saeko Hamaoka, Aiko Kawai, Satoko Chiba,
The importance of perioperative management has been emphasized in recent years so that patients who go through surgeries may return to their normal life as quickly as possible.In achieving this objective, pain management plays a key role in that alleviating pain in the earliest possible timing not only provides favorable effects both physically and psychologically but may also contribute toward preventing development of chronic postsurgical pains (CPSPs).While the actual risk of developing CPSP is ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2020 - | PAIN RESEARCH
Hitoshi Honda, Hiroo Kato, Margaret A. Olsen, Kimberly A. Reske, Mitsutoshi Senoh, Tadashi Fukuda, Yasuaki Tagashira, C Mahé, Erik R. Dubberke, Hiroko Horiuchi, Hiroshi Chiba, Daisuke Suzuki, Naoto Hosokawa, Hidetaka Kitazono, Yasuhiro Norisue, Kume Hisashi, N. Môri, H. Morikawa, Saeko Kashiwagura, Akiko Higuchi, Hiroo Kato, Masakazu Nakamura, Shin Ishiguro, Shinji Morita, Hidehiro Ishikawa, Tomomi Watanabe, K Kojima, Yokomaku Izumi, Tadashi Bando, Toimoto Kayoko, Kei Moriya, Ken Kasahara, Seigo Kitada, J Ogawa, H Saito, Harumi Tominaga, Yūji Shimizu, Fumi Masumoto, Kenjiro Tadera, Joji YOSHIDA, Takefumi Kikuchi, Ichiro Yoshikawa, Tomomi Watanabe, Masahisa Honda, Kumio Yokote, Tatsuya Toyokawa, Hirotaka Miyazato, Masakazu Nakama,
Background Although population characteristics and antimicrobial prescribing practices suggest that the hospitalized population in Japan is at high risk of Clostridioides difficile infection (CDI), the epidemiology of CDI in Japan is poorly understood. Aim This prospective cohort study aimed to investigate the epidemiology of CDI at 12 hospitals in Japan. Methods Patients with clinically significant diarrhoea (CSD) were enrolled. Stool specimens were tested for C. difficile by toxin A and/or B enzyme ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2019 - Elsevier BV | Journal of Hospital Infection
Yuta Matsubara, Hiroki Kiyohara, Yohei Mikami, Kosaku Nanki, Ho Namkoong, Shotaro Chubachi, Hiromu Tanaka, Shuhei Azekawa, Shinya Sugimoto, Yusuke Yoshimatsu, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Toshiro Sato, Makoto Ishii, Naoki Hasegawa, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Koichi Fukunaga, Takanori Kanai∥, Shotaro Chubachi, Ho Namkoong, Takahiro Fukushima, Hiromu Tanaka, Ho Lee, Shiro Otake, Kensuke Nakagawara, Atsuho Morita, Mayuko Watase, Kaori Sakurai, Takunori Ogawa, Takuya Kusumoto, Katsunori Masaki, Hiroki Kabata, Shinnosuke Ikemura, Satoshi Okamori, Hideki Terai, Hirofumi Kamata, Sho Uchida, Shunsuke Uno, Naoki Hasegawa, Kazuhisa Takahashi, Hitoshi Sasano, Yuko Kitagawa, Norihiro Harada, Haruhi Takagi, Ai Nakamura, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Ryosuke Aoki, Sonoko Harada, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Yohei Mikami, Rino Ishihara, Yuta Matsubara, Hiroki Kiyohara, Shinya Sugimoto, Yusuke Yoshimatsu, Tomoyasu Nishimura, Toshiro Sato, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Hasegawa, Yoshinori Yasui, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Etsuko Tagaya, Ken Arimura, Masatoshi Kawana, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takanori Hasegawa, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Masumi Ai, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke ARAI, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Yoshikazu Mutoh, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Takanori Asakura, Tomomi Takano, Kazuhiko Katayama, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Hiroki Tateno, Isano Hase, Shuichi Yoshida, S. Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Junichi Ochi, Keiko Mitamura, Masao Hagihara, Tomoyuki Uchida, Takayuki Shiroyama, Yuichi Maeda, Takuro Nii, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Ryuya Edahiro, Yuya Shirai, Tatsuhiko Naito, Ken-ichi Yamamoto, Haruhiko Hirata, Yoshito Takeda, Shinichi Namba, Ken Suzuki, Kyuto Sonehara, Noa Sasa, Yuya Ueno, Motoyuki Suzuki, Norihiko Takemoto, Hirotaka Eguchi, Takahito Fukusumi, Takao Imai, Hidenori Inohara, Toshihiro Kishikawa, Shuhei Yamada, Shuhei Kawabata, Noriyuki Kijima, Haruhiko Kishima, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Kazunori Tomono, Yoshihiro Kato, Munehisa Fukushima, Masatoshi Takagaki, Atsushi Kumanogoh, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, J. Suzuki, Hiroki Nakatsumi, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Kazuyoshi Watanabe, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Hisako Sageshima, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Shigenari Nukaga, Ryosuke Satomi, Takao Mochimaru, Yoshitaka Oyamada, N. Môri, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo,
Springer Science+Business Media
Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, Shuhei Sakakibara, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Yu‐Chen Liu, Daisuke Motooka, Yoko Naito, Ayako Takuwa, Fuminori Sugihara, Kentaro Tanaka, James B. Wing, Kyuto Sonehara, Yoshihiko Tomofuji, Qingbo Wang, Takanori Hasegawa, Ryunosuke Saiki, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Masahiro Kanai, Tatsuhiko Naito, Noah Sasa, Kenichi Yamamoto, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Masako Ichikawa, Ai Nakamura, Sonoko Harada, Yuuki Sandhu, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Takayuki Shiroyama, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Kazunori Tomono, Yoshihiro Kato, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, J. Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, N. Môri, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita, Kazuhide Ohta, Satoru Sakagami, Kiyoshi Koshida, Kentaro Hayashi, Tetsuo Shimizu, Yutaka Kozu, Hisato Hiranuma, Yasuhiro Gon, Namiki Izumi, Kaoru Nagata, Ken Ueda, Reiko Taki, Satoko Hanada, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Naozumi Hashimoto, Keiko Wakahara, Koji Sakamoto, Norihito Omote, Akira Ando, Nobuhiro Kodama, Yasunari Kaneyama, Shunsuke Maeda, Takashige Kuraki, Takemasa Matsumoto, Koutaro Yokote, Taka‐aki Nakada, Ryuzo Abe, Taku Oshima, Tadanaga Shimada, Masahiro Harada, Takeshi Takahashi, Hiroshi Ono, Toshihiro Sakurai, Takayuki Shibusawa, Yoshifumi Kimizuka,
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 coronavirus disease 2019 (COVID-19) patients and 75 healthy controls of Japanese ancestry with host genetic data. COVID-19 patients showed a low fraction of nonclassical monocytes (ncMono). We report downregulated cell transitions from classical ...
Nature Portfolio
Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee, Takanori Hasegawa, Koji Okudela, Daisuke Okuzaki, Daisuke Motooka, Masahiro Kanai, Tatsuhiko Naito, Kenichi Yamamoto, Qingbo Wang, Ryunosuke Saiki, Rino Ishihara, Yuta Matsubara, Junko Hamamoto, Hiroyuki Hayashi, Yukihiro Yoshimura, Natsuo Tachikawa, Emmy Yanagita, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Ryousuke Aoki, Ai Nakamura, Sonoko Harada, Hitoshi Sasano, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Ken Suzuki, Yoko Naito, Yu‐Chen Liu, Ayako Takuwa, Fuminori Sugihara, James B. Wing, Shuhei Sakakibara, Nobuyuki Hizawa, Takayuki Shiroyama, Satoru Miyawaki, Yusuke Kawamura, Akiyoshi Nakayama, Hirotaka Matsuo, Yuichi Maeda, Takuro Nii, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Toshihiro Kishikawa, Shuhei Yamada, Shuhei Kawabata, Noriyuki Kijima, Masatoshi Takagaki, Noah Sasa, Yuya Ueno, Motoyuki Suzuki, Norihiko Takemoto, Hirotaka Eguchi, Takahito Fukusumi, Takao Imai, Munehisa Fukushima, Haruhiko Kishima, Hidenori Inohara, Kazunori Tomono, Yoshihiro Kato, Meiko Takahashi, Fumihiko Matsuda, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, J. Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, N. Môri, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita,
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1-5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3,289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. ...
Nature Portfolio
Qingbo Wang, Ryuya Edahiro, Ho Namkoong, Takanori Hasegawa, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Ho Lee, Ryunosuke Saiki, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Masahiro Kanai, Tatsuhiko Naito, Noah Sasa, Kenichi Yamamoto, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Masako Ichikawa, Ai Nakamura, Sonoko Harada, Yuuki Sandhu, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashri Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Takayuki Shiroyama, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Kazunori Tomono, Yoshihiro Kato, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, J. Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, N. Môri, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita, Kazuhide Ohta, Satoru Sakagami, Kiyoshi Koshida, Kentaro Hayashi, Tetsuo Shimizu, Yutaka Kozu, Hisato Hiranuma, Yasuhiro Gon, Namiki Izumi, Kaoru Nagata, Ken Ueda, Reiko Taki, Satoko Hanada, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Naozumi Hashimoto, Keiko Wakahara, Koji Sakamoto, Norihito Omote, Akira Ando, Nobuhiro Kodama, Yasunari Kaneyama, Shunsuke Maeda, Takashige Kuraki, Takemasa Matsumoto, Koutaro Yokote, Taka‐aki Nakada, Ryuzo Abe, Taku Oshima, Tadanaga Shimada, Masahiro Harada, Takeshi Takahashi, Hiroshi Ono, Toshihiro Sakurai, Takayuki Shibusawa, Yoshifumi Kimizuka, Akihiko Kawana, Tomoya Sano, Chie Watanabe, Ryohei Suematsu, Hisako Sageshima,
Abstract Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 ...
Nature Portfolio
Satoko Chiba, Keiko Yamada, Aiko Kawai, Saeko Hamaoka, Hiroko Ikemiya, Atsuko Hara, Kenta Wakaizumi, Takahiro Tabuchi, Keisuke Yamaguchi, Izumi Kawagoe, Masako Iseki,
Abstract Purpose This study aimed to investigate whether smoking is an independent risk factor for central sensitization syndrome (CSS) in individuals with pain as measured by the Central Sensitization Inventory (CSI). Methods In 2020, we conducted an Internet survey targeting 2000 ordinary residents of Japan (aged 20–69 years) who had pain symptoms from October to November 2020. A multiple regression analysis was performed on the association between smoking status (nonsmokers and current smokers; Brinkman ...
Tópico(s): Pain Mechanisms and Treatments
2024 - Springer Science+Business Media | Journal of Anesthesia
Yusuke Chiba, Miki Kanai, Akane Fujiwara, Saeko Takase, Asami Arashima, Rie Doi, Shinichi Shimada, Rie Ishii,
ISO/IEC 17025 : 2017 requires laboratories to verify the performance of methods before introducing them. ISO 16140-3 : 2021 employs LOD50 (the level of detection for which 50% of tests give a positive result) as an index for evaluating the performance of microbial qualitative methods. While fecal coliforms and Staphylococcus aureus qualitative methods are widely implemented in Japan, their LOD50 values have not been established, making performance evaluation of these methods impossible at the time of ...
Tópico(s): Data-Driven Disease Surveillance
2022 - | Japanese Journal of Food Microbiology
Yuri Miyakawa, Risako Chiba-Ohkuma, Takeo Karakida, Ryûji Yamamoto, Saeko Kobayashi, Yasuo Yamakoshi, Yoshinobu Asada,
During enamel formation, transforming growth factor-beta (TGF-β) isoforms exhibit different activities for gene expression, apoptosis, and endocytosis. This study aimed to investigate the differential response of TGF-β isoforms to epithelial-mesenchymal transition (EMT) in enamel epithelial cells.Using a mouse enamel epithelial cell line (mHAT9d) cultured in the presence of each TGF-β isoform, (1) the morphological changes in EMT were explored, (2) EMT-related genes were analyzed by next-generation sequencing ( ...
Tópico(s): TGF-β signaling in diseases
2022 - Elsevier BV | Archives of Oral Biology
Kose Segawa, Saburo Nakazawa, Naohiko Koide, Kenji Imai, N. Matsuo, Yoshiki Yamamoto, Masayuki Shiobara, Hayato Shimada, Kazushige Kawai, Katsuhiko Machida, N. Okabe, Y Hoshi, Yuki Koizumi, T. Watanuki, Y. Hiroshima, Yohji Matsusaka, K. Katase, Yojiro Sakuma, Naoya Matoba, Nobuo Murata, Yoichi Toyama, S. Murai, A. Nukaga, Nana Ishimatsu, Yutaka Watanabe, Michio Abe, Yoshifumi Ono, Katsuya Hirai, Shogo Iwabuchi, K. Suzuki, T Aoki, K. Masamura, Kenji Yoshida, J. Ikeuchi, F Nagao, Atsushi Kobayashi, S. Toriie, M. Nakajima, Marc D. Kohli, Kenji Ida, Kazushige Kawai, Masasuke Masuda, T. Hattori, Shoji Fujita, T. Tamada, K. Inoue, Takashi Usui, S. Yamaya, Kuniaki Ohtsuka, Y. Shiraki, Satoru Fujishima, Osamu Tochikubo, S. Miyamoto, A. Ueda, Kenichiro Asano, Makoto Kunisada, Hiroshi Miyake, Yoshitaka Fujii, Sakiya Yoshimoto, K Hiramatsu, Satoko Nakano, T. Takeda, Kimio Kitamura, Y. Horiguchi, K. Okada, M. Okada, Tomoyuki KUWABARA, Masatoshi Tanaka, Kimiaki Konno, T. Hattori, K. Isobe, A. Iwasaki, T. Unoura, Masayuki Matsumoto, Takasuke Yoshida, Isao Takahashi, Michio Abe, Hajime Maeda, T.Terry Hayashi, H. Koizumi, M. Iwasaki, K. Takahashi, Toru Honda, K. Ariga, S. Mohri, Y. Suga, Tokio Ono, K. Kobayashi, T. Mizuno, Yoshiko Sameshima, Y. Shiozaki, M. Sasakawa, Arata Hiramatsu, Kishiko Ikehara, T. Nagata, Kenji Tatsumi, Michio Abe, Mikio Aoki, S. Iwasaki, Toshiyuki Aizawa, Keiji Kajiwara, Kota Sata, S. Omata, K. Imamura, Keiichi Kondo, Hidenori Sajima, Yu Sato, Hiromaro Kiryu, S. Mimoto, T. Masuoka, K. Kira, R. Mizumoto, H. Kuratsuka, I. Honjo, Yudai Hojo, H. Nakajima, Tsuneo Tosaka, Osamu Arai, Nao Kobayashi, Nobuaki Obata, Sadayoshi Ito, Tsuneo TAKAOKA, Y. Uragami, Yoshiaki Kitamura, S Kishi, Soichiro Fujii, Hiroyuki Okuda, K. Hirano, Hideyuki Kano, M. Ogino, Yoshimichi Ueda, Kimitoshi Nishiwaki, Nanami Iwamura, T Aoki, K Hiramatsu, Tomoari Kamada, T. Suematsu, Hideyuki Fusamoto, Hiroshi Okuda, Hirohiko ABE, S. Katayama, K. Yamaguchi, M. Fukuda, Toshiyo ISHII, I. Kaito, Shunichi Sato, Hiroyuki Sasaki, Hideo Onodera, M. Yamanaka, Kazutaka Akagi, Soichiro Miyazaki, M Okumura, T Omae, Y. Nakamura, Masahisa Wada, Y. Nakai, Sumito Inoue, T Arima, S. Yamasaki, T. Takano, Yasumi Katsuta, Tsuyoshi Yano, K. Isoda, Takumi Aramaki, Noboru Fukuda, T Ichikawa, Hidemasa Okumura, Yukihiko Adachi, Daisuke Inoue, Y Iwasaki, S. Tanaka, T. Yamamoto, G Wakisaka, Hideo Nakaya, S. Takase, F. Ikegami, A. Takada, K. Kobayashi, J. Takeuchi, Y. Kato, Akira Funayama, Shinichi Kakumu, Sadayoshi Ito, Sumihiko Okuyama, Y. Taoka, Takashi Endo, R. Chizuka, T. Yanagida, S. Chizuka, Hiroyuki Usui, Takahiro Ando, T. Takai, T. Wakahara, M. Kojima, Toshio Fukazawa, Y. Takahashi, S Miyamura, Tomoaki Urakawa, T. Shima, K. Miyaji, T. Okazaki, S. Kashimura, K. Koyama, H. Yamauchi, Yutaka Matsuo, Y. Takagi, Izumi Muto, Yasuo OWADA, Tsuyoshi OTOWA, T. Sato, Chikayuki NAITO, K. Okada, K. Sugawara, T. Nokiba, Yuki Fujii, Hiroaki Kido, Masato Sasaki, Yoshiro Sugai, Goro Nishimura, H. Nanbu, Y. Kamiyama, Takashi Yamada, Y. Yamaoka, H. Takeda, Tadashi Ohsawa, Toshiki Kamano, T. Mizukami, Osamu Kitamura, K. Ozawa, Hidenari Takasan, I. Honjo, R. Miyasaki, T. Katayama, T. Amakawa, K. Hirose, Y. Furukawa, M. Noguchi, M. Okamoto, H. Maezawa, N. Tanaka, S. Yamada, T. Hisata, C. Hata, Jun Sawa, Y. Kato, Y. Mituda, S. Oohira, A. Hayasaka, T. Okuyama, S. Fukui, T. Takeda, Tomohiro Furuichi, S. Yamamitsu, Kazuyo Yamauchi, Y. Konishi, S. Maeda, S. Setoyama, S. Otsuji, T. Ibata, Haitao Niu, A Ogawa, E. Tujioka, T Maeda, Mitsuhiko Takewa, T. Matumoto, Kiichi Tamada, Akinori Maeda, Hiromi Sumita, Yuya Iseki, S Yukawa, Y. Nitta, K. Isida, Hiroshi Nomoto, S. Setoyama, S. Maeda, S. Otsuji, R. Sato, G. Sato, Satoshi Toyokawa, Goso Yamamoto, S. Ohtomi, M. Haga, Y. Ueno, M. Fukuda, R. Endo, Takashi Yokota, J. Ohsawa, Akira Kohno, Eiichi Ohtoshi, Hachiro Yasugi, Hinako Ichikawa, R. Mizumoto, I. Honjo, K. Ando, Hideaki Suzuki, T. Nishiwaki,
Springer Science+Business Media
Yusuke Chiba, Akane Fujiwara, Noritaka Yoshino, Misa Ohsaka, Mika Sato, Saeko Takase, Rie Doi, Kayoko Ohtsuka, Shinichi Shimada, Rie Ishii,
ヒスタミンは食品中のヒスタミン産生菌により産生されるため食中毒予防には微生物学的制御が求められる．ヒスタミン産生量は温度に影響を受けるため，食品の保存温度は4℃以下が推奨される．しかし実際には常に4℃以下を保つことは難しいことから，本研究ではヒスタミン産生菌7菌種について10℃でのヒスタミン産生能の評価を行った．緩衝液中でヒスタミン産生量の経日変化，菌数とヒスタミン産生量の相関，培地中での増殖速度について検討した．緩衝液中において増殖がない一定の条件下において5日保存してもほぼ一定量のヒスタミンを持続的に産生した．菌数とヒスタミン産生量は比例関係にあり，決定係数は0.97以上であった．また，10℃1日の保存により200 μg/mLのヒスタミンを産生するのに必要な菌量は4×107－4×108CFU/mLと算出された．また，培地中において初期菌量が102－103 CFU/mLであった場合，107 CFU/mL以上となるのに低温細菌で2, 3日，中温細菌で4日以上を要した．以上の結果から，ヒスタミン産生菌のヒスタミン産生能，増殖速度を把握することが食中毒の予防に重要であると考えられた．
Tópico(s): Identification and Quantification in Food
2022 - Japanese Society for Food Hygiene and Safety | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
Shingo Mitsushima, Yuichiro Yahata, Yuuki Tsuchihashi, Chiaki Ikenoue, Munehisa Fukusumi, Shogo Otake, Tomoe Shimada, Takuya Yamagishi, Hajime Kamiya, Yusuke Kobayashi, Hitomi Kurosu, Mai Okuyama, Saeko Morino, Miho Shibamura, Sayaka Takanashi, Taro Kamigaki, Kanako Otani, Manami Nakashita, Hanae Ito, Ayako Miyazaki, Masaya Koshiko, Masanao Harakuni, Megumi Onuma, Hiroko Chiba, Maki Masutani, Natsu Sudani, Yuka Satsuki, Taketoshi Takara, Akira Oka, Tomohiro Katsuta, Naoki Shimizu, Akihiko Saitoh, Tetsuya Sakamoto, Motoi Suzuki, Tomimasa Sunagawa,
To determine the characteristics of pediatric patients 0-19 years of age who died after onset of SARS-CoV-2 infection in Japan during January 1-September 30, 2022, we reviewed multiple sources. We identified 62 cases, collected detailed information from medical records and death certificates, and conducted interviews, resulting in 53 patients with detailed information for our study. Among 46 patients with internal causes of death (i.e., not external causes such as trauma), 15% were <1 year of age, ...
Tópico(s): COVID-19 Clinical Research Studies
2024 - Centers for Disease Control and Prevention | Emerging infectious diseases
Yoshihiko Tomofuji, Ryuya Edahiro, Kyuto Sonehara, Yuya Shirai, Kian Hong Kock, Qingbo Wang, Shinichi Namba, Jonathan Moody, Yoshinari Ando, Akari Suzuki, Tomohiro Yata, Kotaro Ogawa, Tatsuhiko Naito, Ho Namkoong, Quy Xiao Xuan Lin, Eliora Violain Buyamin, Le Min Tan, Radhika Sonthalia, Kyung Yeon Han, Hiromu Tanaka, Ho Lee, Varodom Charoensawan, Chung-Chau Hon, Partha P. Majumder, Ponpan Matangkasombut, Woong‐Yang Park, Shyam Prabhakar, Jay W. Shin, Piero Carninci, John C. Chambers, Marie Loh, Manop Pithukpakorn, Bhoom Suktitipat, Kazuhiko Yamamoto, Deepa Rajagopalan, Nirmala Arul Rayan, Shvetha Sankaran, Juthamard Chantaraamporn, Ankita Chatterjee, Supratim Ghosh, Kyung Yeon Han, Damita Jevapatarakul, Sarintip Nguantad, Sumanta Sarkar, Narita Thungsatianpun, Mai Abe, Seiko Furukawa, Gyo Inoue, Keiko Myouzen, Jin‐Mi Oh, Akari Suzuki, Yoshinari Ando, Miki Kojima, Tsukasa Kouno, Jinyeong Lim, Arindam Maitra, Le Min Tan, Prasanna Nori Venkatesh, Murim Choi, Jong‐Eun Park, Eliora Violain Buyamin, Kian Hong Kock, Quy Xiao Xuan Lin, Jonathan Moody, Radhika Sonthalia, Kazuyoshi Ishigaki, Masahiro Nakano, Yukinori Okada, Yoshihiko Tomofuji, Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee, Takanori Hasegawa, Koji Okudela, Daisuke Okuzaki, Daisuke Motooka, Masahiro Kanai, Tatsuhiko Naito, Kenichi Yamamoto, Qingbo Wang, Ryunosuke Saiki, Rino Ishihara, Yuta Matsubara, Junko Hamamoto, Hiroyuki Hayashi, Yukihiro Yoshimura, Natsuo Tachikawa, Emmy Yanagita, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Ryousuke Aoki, Ai Nakamura, Sonoko Harada, Hitoshi Sasano, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Ken Suzuki, Yoko Naito, Yu‐Chen Liu, Ayako Takuwa, Fuminori Sugihara, James B. Wing, Shuhei Sakakibara, Nobuyuki Hizawa, Takayuki Shiroyama, Satoru Miyawaki, Yusuke Kawamura, Akiyoshi Nakayama, Hirotaka Matsuo, Yuichi Maeda, Takuro Nii, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Toshihiro Kishikawa, Shuhei Yamada, Shuhei Kawabata, Noriyuki Kijima, Masatoshi Takagaki, Noah Sasa, Yuya Ueno, Motoyuki Suzuki, Norihiko Takemoto, Hirotaka Eguchi, Takahito Fukusumi, Takao Imai, Munehisa Fukushima, Haruhiko Kishima, Hidenori Inohara, Kazunori Tomono, Yoshihiro Kato, Meiko Takahashi, Fumihiko Matsuda, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa,
Several X-linked genes escape from X chromosome inactivation (XCI), while differences in escape across cell types and tissues are still poorly characterized. Here, we developed scLinaX for directly quantifying relative gene expression from the inactivated X chromosome with droplet-based single-cell RNA sequencing (scRNA-seq) data. The scLinaX and differentially expressed gene analyses with large-scale blood scRNA-seq datasets consistently identified the stronger escape in lymphocytes than in myeloid ...
Elsevier BV
Saeko Morikawa, Maki Otsuka, Takahiro Yumisashi, Kazushi Motomura,
... no conflicts of interest relevant to this work. Saeko Morikawa affirms that this manuscript is an honest, ... the study as planned have been explained. Conceptualization: Saeko Morikawa, Takahiro Yumisashi Funding Acquisition: Saeko Morikawa Investigation: Saeko Morikawa, Maki Otsuka Writing—Original Draft: Saeko MorikawaWriting—Review and Editing: Maki Otsuka, Takahiro Yumisashi, ... and approved the final version of the manuscript. Saeko Morikawa had full access to all of the ...
Tópico(s): Viral gastroenteritis research and epidemiology
2021 - Wiley | Health Science Reports
Tomohiko Uchida, Masahiro Mori, Akiyuki Uzawa, Saeko Masuda, Mayumi Mutho, Hiroki Masuda, Satoshi Kuwabara,
... provided informed consent and the Ethics Committee of Chiba University Hospital approved this study. Figure 1 shows ...
Tópico(s): Inflammasome and immune disorders
2015 - Wiley | British Journal of Clinical Pharmacology
Noah Sasa, Shohei Kojima, Rie Koide, Takanori Hasegawa, Ho Namkoong, Tomomitsu Hirota, Rei Watanabe, Yuumi Nakamura, Eri Oguro-Igashira, Kotaro Ogawa, Tomohiro Yata, Kyuto Sonehara, Kenichi Yamamoto, Toshihiro Kishikawa, Saori Sakaue, Ryuya Edahiro, Yuya Shirai, Yuichi Maeda, Takuro Nii, Shotaro Chubachi, Hiromu Tanaka, Haruka Yabukami, Akari Suzuki, Kimiko Nakajima, Noriko Arase, Takashi Okamoto, Rika Nishikawa, Shinichi Namba, Tatsuhiko Naito, Ippei Miyagawa, Hiroaki Tanaka, M Ueno, Yosuke Ishitsuka, Junichi Furuta, Kayo Kunimoto, Ikko Kajihara, Satoshi Fukushima, Hideaki Miyachi, Hiroyuki Matsue, Masahiro Kamata, Mami Momose, Toshinori Bito, Hiroshi Nagai, Tetsuya Ikeda, Tatsuya Horikawa, Atsuko Adachi, Tsukasa Matsubara, Kyoko Ikumi, Emi Nishida, Ikuma Nakagawa, Mayu Yagita-Sakamaki, Maiko Yoshimura, Shiro Ohshima, Makoto Kinoshita, Satoru Ito, Toru Arai, Masaki Hirose, Yoshinori Tanino, Takefumi Nikaido, Toshio Ichiwata, Shinya Ohkouchi, Taizou Hirano, Toshinori Takada, Ryushi Tazawa, Konosuke Morimoto, Masahiro Takaki, Satoshi Konno, Masaru Suzuki, Keisuke Tomii, Atsushi Nakagawa, Tomohiro Handa, Kiminobu Tanizawa, Haruyuki Ishii, Manabu Ishida, Toshiyuki Kato, Naoya Takeda, Koshi Yokomura, Takashi Matsui, Akifumi Uchida, Hiromasa Inoue, Kazuyoshi Imaizumi, Yasuhiro Gotô, Hiroshi Kida, Tomoyuki Fujisawa, Takafumi Suda, Takashi Yamada, Yasuomi Satake, Hidenori Ibata, Mika Saigusa, Toshihiro Shirai, Nobuyuki Hizawa, Koh Nakata, Qingbo Wang, Ho Lee, Ryunosuke Saiki, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Masahiro Kanai, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Masako Ichikawa, Ai Nakamura, Sonoko Harada, Yuuki Sandhu, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashri Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Takayuki Shiroyama, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Kazunori Tomono, Yoshihiro Kato, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, J. Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru,
Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease ...
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