Lilian Wikström, Catarina Johansson, Carmen Saltó, Carrolee Barlow, Ángel Campos‐Barros, Frank Baas, Douglas Forrest, Peter Thorén, Björn Vennström,
... more papers by this author Carmen Saltó Carmen Saltó Department of Cell and Molecular Biology, Karolinska Institute, S-17177 Stockholm, Sweden Search for more papers by this author Carrolee Barlow Carrolee Barlow Department of Cell and Molecular Biology, Karolinska Institute, S-17177 Stockholm, Sweden Search for more papers by this author Angel Campos Barros Angel Campos Barros Laboratory of Genetic ... more papers by this author Carmen Saltó Carmen Saltó Department of Cell and Molecular Biology, Karolinska Institute, S-17177 Stockholm, Sweden Search for more papers by this author Carrolee Barlow Carrolee Barlow Department of Cell and Molecular Biology, Karolinska Institute, S-17177 Stockholm, Sweden Search for more papers by this author Angel Campos Barros Angel Campos Barros Laboratory of Genetic ...
Tópico(s): Circadian rhythm and melatonin
1998 - Springer Nature | The EMBO Journal
... low permanent one. When waterfalls are very high (Salto Angel, 900 m, in the Auyan Tepui), their cauldron ...
Tópico(s): Botany and Geology in Latin America and Caribbean
1985 - Association de Geographes Francais | Bulletin de l Association de géographes français
A liverwort collection by Bence Pócs from the Venezuelan Guayana resulted in 31 species of liverworts, including Cololejeunea bencei new to science and C. cardiocarpa, C. obliqua, C. platyneura, C. schusteri, C. verwimpii, Lejeunea pulchra and Plagiochila crispabilis new to Venezuela. The distribution and differentiation of C. schusteri is discussed.
Tópico(s): Lichen and fungal ecology
2021 - Akadémiai Kiadó | Acta Botanica Hungarica
M. Carmen González-García, Carmen Salto-Giron, Pilar Herrero-Foncubierta, Tomás Peña‐Ruiz, María D. Girón, Rafael Salto, Ángel Pérez-Lara, Amparo Navarro, Emilio García‐Fernández, Ángel Orte,
Unraveling cellular physiological processes via luminescent probes that target specific cellular microenvironments is quite challenging due to the uneven distribution of probes. Herein, we designed a new dynamic excimer (DYNEX) imaging method that involves the sensitive detection of nanosecond-scale dynamic molecular contacts of a fluorescent acridone derivative and reveals the cell microenvironment polarity. Using our method, we specifically tracked cell lipid droplets in fibroblast colon carcinoma ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2021 - American Chemical Society | ACS Sensors
Alvaro Ruiz‐Arias, José M. Paredes, Chiara Di Biase, Juan M. Cuerva, María D. Girón, Rafael Salto, Juan A. González‐Vera, Ángel Orte,
In recent years, the prevalence of amyloid neurodegenerative diseases such as Alzheimer’s disease (AD) has significantly increased in developed countries due to increased life expectancy. This amyloid disease is characterized by the presence of accumulations and deposits of β-amyloid peptide (Aβ) in neuronal tissue, leading to the formation of oligomers, fibers, and plaques. First, oligomeric intermediates that arise during the aggregation process are currently thought to be primarily responsible ...
Tópico(s): Computational Drug Discovery Methods
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Miguel Ángel Morales-Inocente, Juan Abel Nájera Luna, Miguel A. Escobedo-Bretado, Francisco Cruz-Cobos, Francisco Javier Hernández, Benedicto Vargas-Larreta,
Los bosques retienen cantidades grandes de CO2 en los principales componentes del ecosistema forestal. El conocimiento sobre esta condición se convierte en una herramienta con potencial para mitigar el cambio climático. Por tanto, este estudio se centra en estimar el carbono retenido en biomasa aérea y suelo en bosques de la región de El Salto, Durango, México. Para ello, información dasométrica y muestras de suelo provenientes de una red de nueve parcelas permanentes de investigación forestal fueron ...
Tópico(s): Agroforestry and silvopastoral systems
2020 - | Investigación y Ciencia de la Universidad Autónoma de Aguascalientes
María Linares, Enriqueta Albízua, Darío Méndez, José Miguel Rubio, Alejandra Martínez-Serna, Miguel Ángel Martínez, Efrén Salto, Antonio Puyet, Amalia Díez, Joaquín Martínez‐López, José M. Bautista,
ABSTRACT We report a case of an African patient with sickle cell trait who was diagnosed in Spain with B-cell lymphoma. Blood smears were negative for malaria, and no plasmodium antigens were detected in the blood. To treat his lymphoma, the patient underwent chemotherapy and autologous stem cell transplantation. Following a splenectomy due to a worsening condition, he developed clinical malaria with detectable parasitemia. This case suggests that the humoral response and parasite removal by the ...
Tópico(s): Vector-borne infectious diseases
2011 - American Society for Microbiology | Journal of Clinical Microbiology
Pilar Herrero-Foncubierta, José M. Paredes, María D. Girón, Rafael Salto, Juan M. Cuerva, D. Miguel, Ángel Orte,
The development of new fluorescent probes for cellular imaging is currently a very active field because of the large potential in understanding cell physiology, especially targeting anomalous behaviours due to disease. In particular, red-emitting dyes are keenly sought, as the light in this spectral region presents lower interferences and a deeper depth of penetration in tissues. In this work, we have synthesized a red-emitting, dual probe for the multiplexed intracellular detection of biothiols ...
Tópico(s): Nanoplatforms for cancer theranostics
2018 - Multidisciplinary Digital Publishing Institute | Sensors
Pilar Herrero-Foncubierta, M. Carmen González-García, Sandra Resa, José M. Paredes, Consuelo Ripoll, María D. Girón, Rafael Salto, Juan M. Cuerva, Ángel Orte, D. Miguel,
In this work the preferential accumulation of long-lived acridone derivatives in mitochondria were evaluated, based on a new concept of non-protonable and non-charged group carriers. In this sense, the thiophene ring has been proved to act, for the first time, as mitochondria targeting group. Moreover, the unique long lifetime of the dyes has allowed the determination of the polarity of the organelles by fluorescence lifetime imaging microscopy (FLIM), without causing remarkable cytotoxicity. The ...
Tópico(s): Lipid Membrane Structure and Behavior
2020 - Elsevier BV | Dyes and Pigments
Roldán Torres Gutiérrez, Klever Iván Granda-Mora, Kassandra del Rocío Bazantes Saltos, Ángel Robles-Carrión,
Plants acquire different combined forms of nitrogen by addition of ammonia and/or nitrate fertilizer or manure to the soil, during organic matter decomposition, by the conversion of nitrogen into different compounds, or by biological nitrogen fixation (BNF). Diverse soil bacteria collectively called rhizobia are capable to fix N2 from the atmosphere through symbiosis with legume plants. The N2 fixed by the legume crops represents a renewable source of nitrogen for agricultural soils, turning symbiotic ...
Tópico(s): Cassava research and cyanide
2021 - Springer Nature | Environmental and microbial biotechnology
Francisco Fueyo‐González, Rosario Herranz, Simona Plesselova, María D. Girón, Rafael Salto, José M. Paredes, Ángel Orte, May C. Morris, Juan A. González‐Vera,
Tópico(s): Ubiquitin and proteasome pathways
2021 - Elsevier BV | Sensors and Actuators B Chemical
Laura Espinar-Barranco, Pilar María Luque-Navarro, Maja A. Strnad, Pilar Herrero-Foncubierta, Luis Crovetto, D. Miguel, María D. Girón, Ángel Orte, Juan M. Cuerva, Rafael Salto, José M. Álvarez‐Pez, José M. Paredes,
In this work, we have performed an in-depth study of the photophysics and solvatofluorochromism of a red-emitting Si-xanthene dye, an analog of Tokyo Magenta (TM) historically developed by Egawa et al. (Chem. Commun. 2011, 47, 4162–4164). The results show a strong dependency of the emission properties of 2-Me-4-OMe-TM on the polarity of the solvent. For instance, the dye exhibited an increase in its fluorescence lifetime with the decrease in solvent polarity. Therefore, in this work, this spectral ...
Tópico(s): Photochromic and Fluorescence Chemistry
2019 - Elsevier BV | Dyes and Pigments
M. Carmen González-García, Tomás Peña‐Ruiz, Pilar Herrero-Foncubierta, D. Miguel, María D. Girón, Rafael Salto, Juan M. Cuerva, Amparo Navarro, Emilio García‐Fernández, Ángel Orte,
The cellular microenvironment is a complex medium due to high concentrations of proteins and an intertwined framework of cellular organelles. In particular, cellular micro-polarity controls several biological processes, since it modulates hydrophobic/hydrophilic interactions and, hence, recognition, signalling and binding events. In this work, we have developed an unprecedented methodology to construct accurate environment polarity images using multiparametric fluorescence microscopy, via a multi- ...
Tópico(s): Photoreceptor and optogenetics research
2020 - Elsevier BV | Sensors and Actuators B Chemical
Los comportamientos de los sujetos obligados a tributar pueden no ser cumplidos de diversas formas, ya sea en una accion concreta como la de ejecutar algun hecho fraudulento como el de omitir dichos mandatos legales o reglamentarios. Dependiendo de la gravedad de estos incumplimientos se podria estar ante una mera infraccion administrativa o de un delito fiscal. Con la elaboracion de este trabajo se recoge el analisis de los elementos de fondo de la figura penal denominado como defraudacion tributaria, ...
Tópico(s): Social Issues and Policies in Latin America
2017 - | Empresarial
... el mágico “lost world” de Guayana con su Salto del Ángel y sus misteriosos tepuis popularizados por Disney. Y ...
Tópico(s): International Relations in Latin America
2012 - American Association of Teachers of Spanish and Portuguese | Hispania
José M. Paredes, María D. Girón, María J. Ruedas-Rama, Ángel Orte, Luis Crovetto, Eva M. Talavera, Rafael Salto, José M. Álvarez‐Pez,
Phosphate ions play important roles in signal transduction and energy storage in biological systems. However, robust chemical sensors capable of real-time quantification of phosphate anions in live cells have not been developed. The fluorescein derivative dye 9-[1-(2-methyl-4-methoxyphenyl)]-6-hydroxy-3H-xanthen-3-one (2-Me-4-OMe TG) exhibits the characteristic excited-state proton-transfer (ESPT) reaction of xanthenic derivatives at approximately physiological pH resulting in the dependence of the ...
Tópico(s): Advanced Fluorescence Microscopy Techniques
2013 - American Chemical Society | The Journal of Physical Chemistry B
Produção Nacional
María Laura Bettolli, Miguel Ángel Altamirano Del Carmen, Gabriela Cruz Brasesco, Frederico de Moraes Rudorff, Arlen Martínez Ortiz, Jacinto Arroyo, J. Armoa,
En este trabajo se evaluó objetivamente la relación entre la variabilidad del rendimiento de la pastura en el departamento de Salto (Uruguay) y la variabilidad climática. Se analizaron también las posibles implicancias del cambio climático futuro. Se utilizaron datos diarios y mensuales de la estación meteorológica Salto en el período 1961-1990 y un registro de datos experimentales de crecimiento de pastura en el período 1980-1994. Adicionalmente, se emplearon salidas diarias de reanálisis del NCEP ...
Tópico(s): Ruminant Nutrition and Digestive Physiology
2010 - Sociedade Brasileira de Meteorologia | Revista Brasileira de Meteorologia
Con la vigencia de la Constitucion de la Republica del Ecuador del ano 2008 el sistema juridico tributario ha abordado su aplicacion en funcion de principios que han sido la base de la instrumentacion de la legislacion y demas normas reglamentarias vigentes en nuestro pais. A traves de la elaboracion de este trabajo se pretende contar con un analisis de los cimientos juridicos de los tributos pero desde la perspectiva del neo constitucionalismo ecuatoriano. Para estos efectos revisamos conceptos ...
Tópico(s): Latin American Legal and Economic Studies
2017 - | Empresarial
Sandra Resa, Ángel Orte, D. Miguel, José M. Paredes, Virginia Puente‐Muñoz, Rafael Salto, María D. Girón, María J. Ruedas-Rama, Juan M. Cuerva, José M. Álvarez‐Pez, Luis Crovetto,
Abstract The simultaneous detection of relevant metabolites in living organisms by using one molecule introduces an approach to understanding the relationships between these metabolites in healthy and deregulated cells. Fluorescent probes of low toxicity are remarkable tools for this type of analysis of biological systems in vivo. As a proof of concept, different naturally occurring compounds, such as biothiols and phosphate anions, were the focus for this work. The 2,4‐dinitrobenzenesulfinate (DNBS) ...
Tópico(s): Luminescence and Fluorescent Materials
2015 - Wiley | Chemistry - A European Journal
G. Aad, E. Abat, B. Abbott, J. Abdallah, A. A. Abdelalim, A. Abdesselam, O. Abdinov, B. Abi, M. Abolins, H. Abramowicz, H. Abreu, E. Acerbi, B. S. Acharya, M. Ackers, D. L. Adams, T. N. Addy, J. Adelman, M. Aderholz, C. Adorisio, P. Adragna, T. Adye, S. Aefsky, J. A. Aguilar–Saavedra, M. Aharrouche, S. P. Ahlen, F. Ahles, A. Ahmad, H. Ahmed, M. Ahsan, G. Aielli, T. Akdoğan, P.F. Åkesson, T. P. A. Åkesson, G. Akimoto, A. V. Akimov, Å. Aktas, M. S. Alam, M. A. Alam, J. Albert, S. Albrand, M. Aleksa, I. N. Aleksandrov, M. Aleppo, F. Alessandria, C. Alexa, G. Alexander, G. Alexandre, T. Alexopoulos, M. Alhroob, M. Aliev, G. Alimonti, J. Alison, M. Aliyev, P. P. Allport, S. E. Allwood-Spiers, J. Almond, A. Aloisio, R. Alon, A. Alonso, J. Alonso, M. G. Alviggi, K. Amako, P. Amaral, Gustavo Ambrosini, G. Ambrosio, C. Amelung, V. V. Ammosov, A. Amorim, E. Ros, N. Amram, C. Anastopoulos, T. Andeen, C. F. Anders, K. J. Anderson, A. Andreazza, V. Andrei, M.-L. Andrieux, X. S. Anduaga, A. Angerami, F. Anghinolfi, N. Anjos, A. Annovi, A. Antonaki, M. Antonelli, S. Antonelli, J. Antoš, B. Antunović, F. Anulli, S. Aoun, G. Arabidze, I. Aracena, Y. Arai, A. T. H. Arce, J. P. Archambault, S. Arfaoui, J-F. Arguin, Theodoros Argyropoulos, E. Arık, M. Arik, A. J. Armbruster, K. Arms, S.R. Armstrong, O. Arnaez, C. Arnault, A. Artamonov, D. Arutinov, M. Asai, S. Asai, R. Asfandiyarov, S. Ask, B. Åsman, D. M. Asner, L. Asquith, K. Assamagan, A. Astbury, A. Astvatsatourov, B Athar, G. Atoian, B. Aubert, B. Auerbach, E. Augé, K. Augsten, M. Aurousseau, N. Austin, G. Avolio, R. Avramidou, D. Axen, C. Ay, G. Azuelos, Y. Azuma, M. A. Baak, G. Baccaglioni, C. Bacci, A. M. Bach, H. Bachacou, K. Bachas, G. Bachy, M. Backes, E. Badescu, P. Bagnaia, Y. Bai, D. Bailey, T. Bain, J. T. Baines, O. K. Baker, M. D. Baker, S. Baker, D. Roda Dos Santos, E. Banaś, P. Banerjee, S. Banerjee, D. Banfi, A. Bangert, V. Bansal, S. P. Baranov, S. P. Baranov, A. Barashkou, T. Barber, E. L. Barberio, D. Barberis, M. Barbero, D.Y. Bardin, T. Barillari, M. Barisonzi, T. Barklow, N. Barlow, B. M. Barnett, R. M. Barnett, A. Baroncelli, M. Barone, A. J. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, P. Barrillon, V. Bartheld, H. Bartko, R. Bartoldus, D. Bartsch, R. L. Bates, S. Bathe, L. Batkova, J. R. Batley, A. Battaglia, M. Battistin, G. Battistoni, F. Bauer, H. S. Bawa, Magdalena Bazalova‐Carter, B. Beare, T. Beau, P. H. Beauchemin, R. Beccherle, N. Becerici, P. Bechtle, H. P. Beck, H. P. Beck, M. Beckingham, K.H. Becks, A. J. Beddall, A. J. Beddall, V. A. Bednyakov, C. P. Bee, M. Begel, S. Behar Harpaz, P. K. Behera, M. Beimforde, G Belanger, C. Bélanger-Champagne, B. Belhorma, P. J. Bell, W. H. Bell, G. Bella, L. Bellagamba, F. Bellina, G. Bellomo, M. Bellomo, A. Belloni, K. Belotskiy, O. Beltramello, A. Belymam, S. Ben Ami, O. Benary, D. Benchekroun, C. Benchouk, M. Bendel, B. H. Benedict, N. Benekos, Y. Benhammou, G. P. Benincasa, B. Trocmé, M. Benoit, J. R. Bensinger, K. Benslama, S. Bentvelsen, M. Beretta, D. Berge, E. Bergeaas Kuutmann, N. Berger, F. Berghaus, E. Berglund, J. Beringer, K. Bernardet, P. Bernat, R. Bernhard, C. Bernius, T. Berry, A. Bertin, F. Bertinelli, S. Bertolucci, M. I. Besana, N. Besson, S. Bethke, R. M. Bianchi, M. Bianco, O. Biebel, M. Bieri, J. Biesiada, M. Biglietti, H. Bilokon, M. Binder, M. Bindi, S. Binet, A. Bingul, C. Bini, C. Biscarat, R. Bischof, U. Bitenc, K. M. Black, R. E. Blair, O. Blanch, J.-B. Blanchard, G. Blanchot, C. Blocker, J. Błocki, A. Blondel, W. Blum, U. Blumenschein, C. Boaretto, G. J. Bobbink, A. Bocci, D. Bocian, R. Böck, G. J. Bobbink, M. Boehm, J. Boek, N. Boelaert, S. Böser, J. A. Bogaerts, A. Bogouch, C. Bohm, J. Böhm, V. Boisvert, T. Bołd, V. Boldea, А. С. Болдырев, В. Г. Бондаренко,
The first measurements from proton-proton collisions recorded with the ATLAS detector at the LHC are presented. Data were collected in December 2009 using a minimum-bias trigger during collisions at a centre-of-mass energy of 900 GeV. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity, and the relationship between mean transverse momentum and charged-particle multiplicity are measured for events with at least one charged particle in the kinematic range |eta| ...
Elsevier BV
Julio Plaza‐Díaz, Manuel Manzano, Francisco Javier Ruiz‐Ojeda, María D. Girón, Rafael Salto, José M. López-Pedrosa, A. Santos-Fandila, Maria Teresa Garcia-Corcoles, Ricardo Rueda, Ángel Gil,
Introduction The main cause of insulin resistance in childhood is obesity, which contributes to future comorbidities as in adults. Although high-calorie diets and lack of exercise contribute to metabolic disease development, food quality rather than the quantity of macronutrients is more important than food density. The purpose of the present study was to examine the effects of changing the quality of carbohydrates from rapidly to slowly digestible carbohydrates on the composition of the gut microbiota ...
Tópico(s): Diet and metabolism studies
2022 - Frontiers Media | Frontiers in Nutrition
Gabriela Martínez de la Escalera, Carla Kruk, Ángel M. Segura, Claudia Piccini,
It is widely known that the environmental conditions caused by the construction of reservoirs favor the proliferation of toxic cyanobacteria and the formation of blooms due to the high residence time of the water, low turbidity, temperature regimes, among others. Microcystin-producing cyanobacteria such as those from the Microcystis aeruginosa complex (MAC) are the most frequently found organisms in reservoirs worldwide, being the role of the environment on microcystin production poorly understood. ...
Tópico(s): Microbial Community Ecology and Physiology
2023 - Elsevier BV | Harmful Algae
Umberto Malapelle, Clara Mayo‐de‐las‐Casas, Miguel Ángel Molina‐Vila, Rafael Rosell, Spasenija Savic, Michel Bihl, Lukas Bubendorf, Manuel Salto‐Tellez, Dario de Biase, Giovanni Tallini, David H. Hwang, Lynette M. Sholl, Rajyalakshmi Luthra, Birgit Weynand, Sara Vander Borght, Edoardo Missiaglia, Massimo Bongiovanni, Daniel Stieber, Philippe Vielh, Fernando Schmitt, Alessandra Rappa, Massimo Barberis, Francesco Pepe, Pasquale Pisapia, Nicola Serra, Elena Vigliar, Claudio Bellevicine, Matteo Fassan, Massimo Rugge, Carlos E. de Andrea, María D. Lozano, Fulvio Basolo, Gabriella Fontanini, Yuri E. Nikiforov, Suzanne Kamel‐Reid, Gilda da Cunha Santos, Marina N. Nikiforova, Sinchita Roy‐Chowdhuri, Giancarlo Troncone,
Molecular testing of cytological lung cancer specimens includes, beyond epidermal growth factor receptor (EGFR), emerging predictive/prognostic genomic biomarkers such as Kirsten rat sarcoma viral oncogene homolog (KRAS), neuroblastoma RAS viral [v-ras] oncogene homolog (NRAS), B-Raf proto-oncogene, serine/threonine kinase (BRAF), and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA). Next-generation sequencing (NGS) and other multigene mutational assays are suitable for cytological ...
Tópico(s): Genomics and Rare Diseases
2017 - Wiley | Cancer Cytopathology
Felipe García‐Pinillos, Alberto Ruiz‐Ariza, Ana Vanessa Navarro-Martínez, Pedro Ángel Latorre Román,
Tópico(s): Children's Physical and Motor Development
2014 - Generalitat of Catalonia | Apunts Medicina de l Esport
Produção Nacional
Aline Siteneski, Leonardo D. Jalca Cantos, Emily P. Calderón Delgado, Ruth M. Yaguache Celi, César A. Silva Saltos, Angel Zamora, Mónica Mastarreno, Diego Portalanza,
Traffic accidents are serious public health problems, account for profound economic costs to individuals, families, and societies. The social impacts range from physiological to economic causes, which could be a serious negative effect, especially in undeveloped countries. To further elucidate this problem, the prevalence of injuries caused by traffic accidents in a Santa Ana Health Centre, Portoviejo, Ecuador, was studied. This registry-based retrospective study analyzed data on Santa Ana, from ...
Tópico(s): Trauma and Emergency Care Studies
2021 - Universidad Católica de Oriente | Bionatura
Joaquín Frenguelli, Ángel Cabrera,
Tópico(s): Urbanism, Landscape, and Tourism Studies
1937 - | Revista del Museo de La Plata
El presente estudio tuvo como propósito determinar la relación entre fuerza del tren inferior, la huella plantar y el salto horizontal en alumnos de primaria. La modalidad metodológica correspondió a un enfoque cuantitativo descriptivo de tipo experimental. Para la recolección de los datos, se utilizó la medición de la huella plantar con el fin de determinar el tipo de pie en los estudiantes y, se aplicó la prueba de salto horizontal sin impulso como instrumento. La población del estudio fueron ...
Tópico(s): Various Academic Research Studies
2023 - | MENTOR revista de investigación educativa y deportiva
... ejecutivos latinoamericanos estan dando ?o evaluando dar? el salto necesario para convertirse en un ?inversionista angel?. Esto no quiere decir que el perfil del ...
Tópico(s): Business, Innovation, and Economy
2006 - Harvard Business Publishing | Harvard business review
Lelly María Useche Castro, Olga Lilian Mendoza Talledo, Rosalba Karen Bravo Saltos, Miguel Ángel Lapo Palacios,
Se determinó un perfil de la infraestructura de una población rural en Venezuela con respecto a la vivienda según el sector, realizando un análisis de correspondencias simple en donde se compararon las variables de infraestructura con respecto a la variable “sector”. La base de datos se obtuvo de una investigación previa basada en un cuestionario del censo de población y vivienda del Instituto Nacional de Estadística (INE) de una muestra de 226 hogares. Los resultados obtenidos variaron según el tipo ...
Tópico(s): Logistics and Transportation Systems
2019 - Universidad Técnica de Manabí | Revista Bases de la Ciencia
Carolina Muñoz‐Novas, Isabel González-Gascón-y-Marín, Íñigo Rúa‐Figueroa, Laura Sánchez-Paz, Claudia Pérez‐Carretero, Miguel Quijada‐Álamo, Ana‐Eugenia Rodríguez‐Vicente, María Stefania Infante, María Ángeles Foncillas, Elena Landete, Juan Churruca, Karen Marín, Victoria Ramos, Alejandro Sánchez Salto, José‐Ángel Hernández‐Rivas,
Abstract Immunoglobulin heavy chain variable (IGHV) region mutations, TP53 mutation, fluorescence in situ hybridization (FISH), and cytogenetic analysis are the most important prognostic biomarkers used in chronic lymphocytic leukemia (CLL) patients in our daily practice. In real-life environment, there are scarce studies that analyze the correlation of these factors with outcome, mainly referred to time to first treatment (TTFT) and overall survival (OS). This study aimed to typify IGHV mutation status, ...
Tópico(s): Lymphoma Diagnosis and Treatment
2024 - Georg Thieme Verlag | Global Medical Genetics