Eli D. Sone, Eugene R. Zubarev, Samuel I. Stupp,
... USASearch for more papers by this authorSamuel I. Stupp Prof., Samuel I. Stupp Prof. s-stupp@northwestern.edu Department of ... USASearch for more papers by this authorSamuel I. Stupp Prof., Samuel I. Stupp Prof. s-stupp@northwestern.edu Department of Chemistry, ...
Tópico(s): Copper-based nanomaterials and applications
2005 - Wiley | Small
James F. Hulvat, Samuel I. Stupp,
... 3010Search for more papers by this authorSamuel I. Stupp Prof., Samuel I. Stupp Prof. [email protected] Department of Materials Science ... 3010Search for more papers by this authorSamuel I. Stupp Prof., Samuel I. Stupp Prof. [email protected] Department of Materials Science and ...
Tópico(s): Organic Electronics and Photovoltaics
2003 - Wiley | Angewandte Chemie
James F. Hulvat, Samuel I. Stupp,
... 3010Search for more papers by this authorSamuel I. Stupp Prof., Samuel I. Stupp Prof. s-stupp@northwestern.edu Department of ... 3010Search for more papers by this authorSamuel I. Stupp Prof., Samuel I. Stupp Prof. s-stupp@northwestern.edu Department of Materials ...
Tópico(s): Photochromic and Fluorescence Chemistry
2003 - Wiley | Angewandte Chemie International Edition
Jiaxin Duan, Hafeera Shabbir, Zhihengyu Chen, Wentuan Bi, Qin Liu, Jingyi Sui, Luka Đorđević∞, Samuel I. Stupp, Karena W. Chapman, Alex B. F. Martinson, Alice Li, Richard D. Schaller, Subhadip Goswami, Rachel B. Getman, Joseph T. Hupp,
Polyoxometalates (POMs) featuring 7, 12, 18, or more redox-accessible transition metal ions are ubiquitous as selective catalysts, especially for oxidation reactions. The corresponding synthetic and catalytic chemistry of stable, discrete, capping-ligand-free polythiometalates (PTMs), which could be especially attractive for reduction reactions, is much less well developed. Among the challenges are the propensity of PTMs to agglomerate and the tendency for agglomeration to block reactant access of ...
Tópico(s): Nanocluster Synthesis and Applications
2023 - American Chemical Society | Journal of the American Chemical Society
Liam C. Palmer, Christina J. Newcomb, Stuart R. Kaltz, Erik David Spoerke, Samuel I. Stupp,
... Newcomb‡, Stuart R. Kaltz‡, Erik D. Spoerke‡§, and Samuel I. Stupp*†‡∥⊥View Author Information Departments of Chemistry and Materials ...
Tópico(s): Bone and Dental Protein Studies
2008 - American Chemical Society | Chemical Reviews
... article is based on a presentation given by Samuel I. Stupp of Northwestern University as part of Symposium X— ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2005 - Springer Nature | MRS Bulletin
Chuang Li, Masoud Kazem‐Rostami, James S. W. Seale, Shuailong Zhou, Samuel I. Stupp,
Living organisms use the amplification of molecular motions over orders of magnitude to produce deformation, motion, and function on the macroscale. The design of artificial molecular machines that can mimic their biological counterparts in the production of such macroscopic actuation is of great interest. Here, we designed a polymerizable bisazobenzene-based molecular photoswitch that displays a highly directional geometrical transformation upon photoisomerization. When this photoswitch is incorporated ...
Tópico(s): Supramolecular Self-Assembly in Materials
2023 - American Chemical Society | Chemistry of Materials
Abstract Ranging from 2D assemblies to peptide amphiphile‐based biomaterials, Prof. Samuel Stupp and his team have enriched the scientific community with many breakthroughs in the field of supramolecular self‐assembly. This Interview offers the unique possibility to share some highlights along his journey, providing also a glimpse to his vision of the future of supramolecular chemistry. Interdisciplinarity is an integral part of Prof. Stupp's research philosophy, and, using his own words, “it is ...
Tópico(s): Supramolecular Chemistry and Complexes
2020 - | Advanced Materials
Neel A. Mansukhani, Erica B. Peters, Miranda So, Mazen Albaghdadi, Zheng Wang, Mark R. Karver, Tristan D. Clemons, Jeffrey P. Laux, Nick D. Tsihlis, Samuel I. Stupp, Melina R. Kibbe,
... D. Clemons, Jeffrey P. Laux, Nick D. Tsihlis, Samuel I. Stupp, and Melina R. Kibbe in article 1900066.
Tópico(s): Chemical Synthesis and Analysis
2019 - Wiley | Macromolecular Bioscience
Zaida Álvarez, José Antonio Ortega, Kohei Sato, Ivan R. Sasselli, Alexandra N. Edelbrock, Ruomeng Qiu, Kelly A. Marshall, Thao Phuong Nguyen, Cara S. Smith, Katharina A. Quinlan, Vasileios Papakis, Zois Syrgiannis, Nicholas A. Sather, Chiara Musumeci, Elisabeth Engel, Samuel I. Stupp, Evangelos Kiskinis,
Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for modeling neurological diseases. However, iPSC models are fraught with technical limitations including abnormal aggregation and inefficient maturation of differentiated neurons. These problems are in part due to the absence of synergistic cues of the native extracellular matrix (ECM). We report on the use of three artificial ECMs based on peptide amphiphile (PA) supramolecular nanofibers. All nanofibers display the ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2023 - Elsevier BV | Cell stem cell
Eric P. Bruckner, Samuel I. Stupp,
Abstract The self‐assembly of small molecules into supramolecular polymers can be analogous to the formation of classical solid‐state crystals depending on the mechanism of polymerization. Taking inspiration from the field of materials science, complex supramolecular polymer nanostructures can be formed by carefully controlling nucleation and growth processes. Exploration of the energy landscapes in supramolecular polymers can also lead to the discovery of polymorphs where a single monomer can self‐ ...
Tópico(s): Polymer composites and self-healing
2022 - Wiley | Polymer International
Ruomeng Qiu, Ivan R. Sasselli, Zaida Álvarez, Hiroaki Sai, Wei Ji, Liam C. Palmer, Samuel I. Stupp,
Supramolecular peptide chemistry offers a versatile strategy to create chemical systems useful as new biomaterials with potential to deliver nearly 1000 known candidate peptide therapeutics or integrate other types of bioactivity. We report here on the co-assembly of lipidated β-sheet-forming peptides with soluble short peptides, yielding supramolecular copolymers with various degrees of internal order. At low peptide concentrations, the co-monomer is protected by lodging within internal aqueous ...
Tópico(s): RNA Interference and Gene Delivery
2022 - American Chemical Society | Journal of the American Chemical Society
Shelby C. Yuan, Jacob A. Lewis, Hiroaki Sai, Steven J. Weigand, Liam C. Palmer, Samuel I. Stupp,
Pathways in supramolecular polymerization traverse different regions of the system's energy landscape, affecting not only their architectures and internal structure but also their functions. We report here on the effects of pathway selection on polymerization for two isomeric peptide amphiphile monomers with amino acid sequences AAEE and AEAE. We subjected the monomers to five different pathways that varied in the order they were exposed to electrostatic screening by electrolytes and thermal annealing. ...
Tópico(s): Luminescence and Fluorescent Materials
2022 - American Chemical Society | Journal of the American Chemical Society
Amine Garci, Seifallah Abid, Arthur H. G. David, Marcos D. Codesal, Luka Đorđević∞, Ryan M. Young, Hiroaki Sai, Laura Le Bras, Aurélie Perrier, Marco Ovalle, P. Brown, Charlotte L. Stern, Araceli G. Campaña, Samuel I. Stupp, Michael R. Wasielewski, Víctor Blanco, J. Fraser Stoddart,
Here, we report an approach to the synthesis of highly charged enantiopure cyclophanes by the insertion of axially chiral enantiomeric binaphthyl fluorophores into the constitutions of pyridinium-based macrocycles. Remarkably, these fluorescent tetracationic cyclophanes exhibit a significant AIE compared to their neutral optically active binaphthyl precursors. A combination of theoretical calculations and time-resolved spectroscopy reveal that the AIE originates from limited torsional vibrations ...
Tópico(s): DNA and Nucleic Acid Chemistry
2022 - Wiley | Angewandte Chemie International Edition
Oliver Dumele∞, Luka Đorđević∞, Hiroaki Sai, Thomas J. Cotey, M. Hussain Sangji, Kohei Sato, Adam J. Dannenhoffer, Samuel I. Stupp,
There has been rapid progress on the chemistry of supramolecular scaffolds that harness sunlight for aqueous photocatalytic production of hydrogen. However, great efforts are still needed to develop similar photosynthetic systems for the great challenge of CO2 reduction especially if they avoid the use of nonabundant metals. This work investigates the synthesis of supramolecular polymers capable of sensitizing catalysts that require more negative potentials than proton reduction. The monomers are ...
Tópico(s): CO2 Reduction Techniques and Catalysts
2022 - American Chemical Society | Journal of the American Chemical Society
Francesca Arcudi, Luka Đorđević∞, Neil M. Schweitzer, Samuel I. Stupp, Emily A. Weiss,
The production of polymers from ethylene requires the ethylene feed to be sufficiently purified of acetylene contaminant. Accomplishing this task by thermally hydrogenating acetylene requires a high temperature, an external feed of H2 gas and noble-metal catalysts. It is not only expensive and energy-intensive, but also prone to overhydrogenating to ethane. Here we report a photocatalytic system that reduces acetylene to ethylene with ≥99% selectivity under both non-competitive (no ethylene co-feed) ...
Tópico(s): CO2 Reduction Techniques and Catalysts
2022 - Nature Portfolio | Nature Chemistry
Chuang Li, Yeguang Xue, Mengdi Han, Liam C. Palmer, John A. Rogers, Yonggang Huang, Samuel I. Stupp,
Development of stimuli-responsive soft matter that undergoes fast and reversible shape changes that mimic living organisms is a grand challenge for materials science. We report here on the molecular design of photoactive bilayer actuators that can rapidly respond to visible light, leading to complex but predictable bio-inspired shape changes. The mechanism of accelerated actuation is rooted in the simultaneous photoexpansion of one layer and photocontraction of the other triggered by the same light ...
Tópico(s): Supramolecular Self-Assembly in Materials
2021 - Elsevier BV | Matter
Zaida Álvarez, Alexandra N. Edelbrock, Ivan R. Sasselli, Juan A. Ortega, Ruomeng Qiu, Zois Syrgiannis, Peter A. Mirau, F. Chen, Stacey M. Chin, Steven Weigand, Evangelos Kiskinis, Samuel I. Stupp,
Fibril motion improves peptide signaling Artificial scaffolds that bear the peptide-signaling sequences of proteins for tissue regeneration often have limited effectiveness. Álvarez et al . synthesized supramolecular peptide fibril scaffolds bearing two peptide sequences that promote nerve regeneration, one that reduces glial scarring and another that promotes blood vessel formation (see the Perspective by Wojciechowski and Stevens). In a mouse model of paralyzing human spinal cord injury, mutations ...
Tópico(s): Neuropeptides and Animal Physiology
2021 - American Association for the Advancement of Science | Science
Adam J. Dannenhoffer, Hiroaki Sai, Boris Harutyunyan, Ashwin Narayanan, Natalia E. Powers‐Riggs, Alexandra N. Edelbrock, James Passarelli, Steven J. Weigand, Michael R. Wasielewski, Michael J. Bedzyk, Liam C. Palmer, Samuel I. Stupp,
The control of morphology in bioinspired chromophore assemblies is key to the rational design of functional materials for light harvesting. We investigate here morphological changes in perylene monoimide chromophore assemblies during thermal annealing in aqueous environments of high ionic strength to screen electrostatic repulsion. We found that annealing under these conditions leads to the growth of extra-large ribbon-shaped crystalline supramolecular polymers of widths from about 100 nm to several ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2021 - American Chemical Society | Nano Letters
Xiao‐Yang Chen, Haoyuan Chen, Luka Đorđević∞, Qing‐Hui Guo, Huang Wu, Yu Wang, Long Zhang, Yang Jiao, Kang Cai, Hongliang Chen, Charlotte L. Stern, Samuel I. Stupp, Randall Q. Snurr, Dengke Shen, J. Fraser Stoddart,
For the most part, enzymes contain one active site wherein they catalyze in a serial manner chemical reactions between substrates both efficiently and rapidly. Imagine if a situation could be created within a chiral porous crystal containing trillions of active sites where substrates can reside in vast numbers before being converted in parallel into products. Here, we report how it is possible to incorporate 1-anthracenecarboxylate (1-AC-) as a substrate into a γ-cyclodextrin-containing metal-organic ...
Tópico(s): Polyoxometalates: Synthesis and Applications
2021 - American Chemical Society | Journal of the American Chemical Society
Naneki C. McCallum, Florencia A. Son, Tristan D. Clemons, Steven J. Weigand, Karthikeyan Gnanasekaran, Claudia Battistella, Brooke E. Barnes, Hashanthi K. Abeyratne-Perera, Zofia E. Siwicka, Christopher J. Forman, Xuhao Zhou, M. H. Moore, Daniel A. Savin, Samuel I. Stupp, Zheng Wang, Gary J. Vora, Brandy J. Johnson, Omar K. Farha, Nathan C. Gianneschi,
Melanin is a ubiquitous natural pigment found in a diverse array of organisms. Allomelanin is a class of nitrogen-free melanin often found in fungi. Herein, we find artificial allomelanin analogues exhibit high intrinsic microporosity and describe an approach for further increasing and tuning that porosity. Notably, the synthetic method involves an oxidative polymerization of 1,8-DHN in water, negating the need for multiple complex templating steps and avoiding expensive or complex chemical precursors. ...
Tópico(s): Surface Modification and Superhydrophobicity
2021 - American Chemical Society | Journal of the American Chemical Society
Niklas Grabicki, Oliver Dumele∞, Hiroaki Sai, Natalia E. Powers‐Riggs, Brian T. Phelan, M. Hussain Sangji, Craig T. Chapman, James Passarelli, Adam J. Dannenhoffer, Michael R. Wasielewski, Samuel I. Stupp,
Supramolecular polymers can emulate some of the physical properties of covalent polymers but offer new opportunities given the possibility of designing monomers that will form highly ordered assemblies with defined shapes. Internally ordered supramolecular polymers formed through nucleation–elongation self-assembly are well-known but highly crystalline examples which exhibit important properties such as light harvesting, charge transport, and ferroelectricity are not common. We report here on a ...
Tópico(s): Luminescence and Fluorescent Materials
2021 - American Chemical Society | Chemistry of Materials
Nicholas A. Sather, Hiroaki Sai, Ivan R. Sasselli, Kohei Sato, Wei Ji, Christopher V. Synatschke, Ryan T. Zambrotta, John F. Edelbrock, Ryan R. Kohlmeyer, James O. Hardin, John D. Berrigan, Michael F. Durstock, Peter A. Mirau, Samuel I. Stupp,
Abstract Liquid crystalline hydrogels are an attractive class of soft materials to direct charge transport, mechanical actuation, and cell migration. When such systems contain supramolecular polymers, it is possible in principle to easily shear align nanoscale structures and create bulk anisotropic properties. However, reproducibly fabricating and patterning aligned supramolecular domains in 3D hydrogels remains a challenge using conventional fabrication techniques. Here, a method is reported for ...
Tópico(s): Hydrogels: synthesis, properties, applications
2021 - Wiley | Small
Alexandra N. Edelbrock, Tristan D. Clemons, Stacey M. Chin, Joshua J. W. Roan, Eric P. Bruckner, Zaida Álvarez, John F. Edelbrock, Kristen S. Wek, Samuel I. Stupp,
Abstract Dynamic and reversible assembly of molecules is ubiquitous in the hierarchical superstructures of living systems and plays a key role in cellular functions. Recent work from the laboratory reported on the reversible formation of such superstructures in systems of peptide amphiphiles conjugated to oligonucleotides and electrostatically complimentary peptide sequences. Here, a supramolecular system is reported upon where exchange dynamics and host–guest interactions between β ‐cyclodextrin ...
Tópico(s): Supramolecular Chemistry and Complexes
2021 - Wiley | Advanced Science
Charlotte H. Chen, Liam C. Palmer, Samuel I. Stupp,
Two minority fluorescent constituents of a multicomponent supramolecular system undergo self-sorting, mediated by their electrostatic interactions with a third non-fluorescent constituent that comprises 99 mol% of the system.
Tópico(s): Supramolecular Chemistry and Complexes
2021 - Royal Society of Chemistry | Soft Matter
M. Hussain Sangji, Hiroaki Sai, Stacey M. Chin, Sieun Ruth Lee, Ivan R. Sasselli, Liam C. Palmer, Samuel I. Stupp,
The morphology of supramolecular peptide nanostructures is difficult to predict given their complex energy landscapes. We investigated peptide amphiphiles containing β-sheet forming domains that form twisted nanoribbons in water. We explained the morphology based on a balance between the energetically favorable packing of molecules in the center of the nanostructures, the unfavorable packing at the edges, and the deformations due to packing of twisted β-sheets. We find that morphological polydispersity ...
Tópico(s): Antimicrobial Peptides and Activities
2021 - American Chemical Society | Nano Letters
Yang Jiao, Luka Đorđević∞, Haochuan Mao, Ryan M. Young, Tyler L. Jaynes, Hongliang Chen, Yunyan Qiu, Kang Cai, Long Zhang, Xiao‐Yang Chen, Yuanning Feng, Michael R. Wasielewski, Samuel I. Stupp, J. Fraser Stoddart,
Colored charge-transfer complexes can be formed by the association between electron-rich donor and electron-deficient acceptor molecules, bringing about the narrowing of HOMO–LUMO energy gaps so that they become capable of harnessing visible light. In an effort to facilitate the use of these widespread, but nonetheless weak, interactions for visible light photocatalysis, it is important to render the interactions strong and robust. Herein, we employ a well-known donor–acceptor [2]catenane—formed ...
Tópico(s): Supramolecular Chemistry and Complexes
2021 - American Chemical Society | Journal of the American Chemical Society
Francesca Arcudi, Luka Đorđević∞, Benjamin Nagasing, Samuel I. Stupp, Emily A. Weiss,
Climate change and global energy demands motivate the search for sustainable transformations of carbon dioxide (CO2) to storable liquid fuels. Photocatalysis is a pathway for direct conversion of CO2 to CO, one step within light-powered reaction networks that could, if efficient enough, transform the solar energy conversion landscape. To date, the best performing photocatalytic CO2 reduction systems operate in nonaqueous solvents, but technologically viable solar fuels networks will likely operate ...
Tópico(s): Quantum Dots Synthesis And Properties
2021 - American Chemical Society | Journal of the American Chemical Society
Hao Sun, Wei Cao, Nanzhi Zang, Tristan D. Clemons, Georg M. Scheutz, Ziying Hu, Matthew P. Thompson, Yifei Liang, Maria A. Vratsanos, Xuhao Zhou, Wonmin Choi, Brent S. Sumerlin, Samuel I. Stupp, Nathan C. Gianneschi,
Herein, we report the photoinitiated polymerization-induced self-assembly (photo-PISA) of spherical micelles consisting of proapoptotic peptide-polymer amphiphiles. The one-pot synthetic approach yielded micellar nanoparticles at high concentrations and at scale (150 mg mL-1 ) with tunable peptide loadings up to 48 wt. %. The size of the micellar nanoparticles was tuned by varying the lengths of hydrophobic and hydrophilic building blocks. Critically, the peptide-functionalized nanoparticles imbued the ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2020 - Wiley | Angewandte Chemie International Edition
Samuel I. Stupp, Tristan D. Clemons, James K. Carrow, Hiroaki Sai, Liam C. Palmer,
Abstract Staudinger established a century ago the existence of covalent macromolecules, work that led to the development of transformative materials of great benefit to society and a “quantum leap” in our understanding of biological systems. Over the past few decades the concept of supramolecular polymers has emerged–chemical systems in which structural units bond strongly to each other non‐covalently. These dynamic systems actually exist in the natural world and can create soft materials with structures, ...
Tópico(s): Polymer composites and self-healing
2020 - Wiley | Israel Journal of Chemistry