Teresa Serra, Sandra Silva, Luís F. Gouveia, A.M.R.C. Alexandre, Carolina V. Pereira, Ana Bárbara Pereira, Ana Carvalho Partidário, Nuno Silva, Torsten Bohn, V.S.S. Gonçalves, Gonçalo Real, Pedro Escudero, Naiara Fernández, Ana A. Matias, Maria Rosário Bronze,
The beneficial health effects of Chlorella vulgaris have been associated with the presence of several nutrients and antioxidants, including carotenoids. However, the in vivo bioavailability of Chlorella is still poorly evaluated. In this work, a human intervention study was conducted in 11 healthy men to evaluate the bioavailability of carotenoids within 3 days after the intake of a single dose (6 g) of dried marine Chlorella vulgaris containing lutein (7.08 mg), β-carotene (1.88 mg) and zeaxanthin ( ...
Tópico(s): Aquaculture Nutrition and Growth
2021 - Multidisciplinary Digital Publishing Institute | Antioxidants
Myriam M.-L. Grundy, Evan Abrahamse, Annette Almgren, Marie Alminger, Ana Andrés, Renata M.C. Ariëns, Shanna Bastiaan-Net, Claire Bourlieu‐Lacanal, André Brodkorb, Maria Rosário Bronze, Irene Comi, Leslie Couëdelo, Didier Dupont, Annie Durand, Sedef Nehir El, Tara Grauwet, Christine Heerup, Ana Heredia, M.R. Infantes-Garcia, Christian Jungnickel, Ilona E. Kłosowska-Chomiczewska, Marion Létisse, Adam Macierzanka, Alan R. Mackie, David Julian McClements, Olivia Ménard, Anne Meynier, Marie‐Caroline Michalski, Ana-Isabel Mulet-Cabero, Anette Müllertz, Francina M. Payeras Perelló, I. Peinado, Mélina Robert, Sébastien Secouard, Teresa Serra, Sandra Silva, Gabriël G. M. Thomassen, Cecilia Tullberg, Ingrid Undeland, Carole Vaysse, Gerd E. Vegarud, S.H.E. Verkempinck, Michelle Viau, Mostafa Zahir, Ruojie Zhang, Frédéric Carrière,
In vitro digestion studies often use animal digestive enzyme extracts as substitutes of human gastric and pancreatic secretions. Pancreatin from porcine origin is thus commonly used to provide relevant pancreatic enzymes such as proteases, amylase and lipase. Rabbit gastric extracts (RGE) have been recently introduced to provide gastric lipase in addition to pepsin. Before preparing simulated gastric and pancreatic extracts with targeted enzyme activities as described in in vitro digestion protocols, ...
Tópico(s): Proteins in Food Systems
2021 - Elsevier BV | Journal of Functional Foods
Marta Navarrete, María Isabel Cuartero, Rocío Palenzuela, Jonathan E. Draffin, Ainoa Konomi, Irene Serra, Sandra Colié, Sergio Castaño-Castaño, Mazahir T. Hasan, Ángel R. Nebreda, José A. Esteban,
Abstract NMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. The core mechanism for this form of plasticity is thought to be entirely neuronal. However, we now demonstrate that astrocytic activity drives LTD at CA3-CA1 synapses. We have found that LTD induction enhances astrocyte-to-neuron communication mediated by glutamate, and that Ca 2+ signaling and SNARE-dependent vesicular release ...
Tópico(s): Photoreceptor and optogenetics research
2019 - Nature Portfolio | Nature Communications
Produção Nacional
Revisado por pares
Rosana Denobile Serra, Sandra Lopes Mattos e Dinato, Marcos Montani Caseiro,
ABSTRACT Objective Ascertain the prevalence of depressive and anxiety symptoms in medical students, considering data in the literature that indicate higher vulnerability to emotional disorders in this population. Methods A descriptive cross-sectional study with a sample of 657 (98%) students. The instruments used were: questionnaire of socioeconomic-demographic characteristics, Beck Depression Inventory and Beck Anxiety Inventory. Results Predominance of the female gender (61%), aged between 17 and ...
Tópico(s): Occupational Health and Burnout
2015 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Jornal Brasileiro de Psiquiatria
Alessandro Serra, Sandra Nuti, Simona Tavarini, Chiara Sammicheli, Domenico Rosa, Giulietta Saletti, Elisabetta Soldaini, Sergio Abrignani, Andreas Wack,
Abstract Costimuli provide supplementary signals required by naive T cells to become fully activated upon Ag encounter. Tetraspanins are a large family of transmembrane proteins that can costimulate T cells when engaged in vitro. In this study, we describe for the first time that coligation of the tetraspanins CD81, CD82, or CD9 with the costimulatory molecule CD28 in vitro leads to proliferation of naive T cells. When activated through this pathway, both CD4+ and CD8+ naive T cells differentiate ...
Tópico(s): Hepatitis C virus research
2008 - American Association of Immunologists | The Journal of Immunology
Robert A. Houze, Shuyi S. Chen, David E. Kingsmill, Yolande L. Serra, Sandra E. Yuter,
Deep convection over the western tropical Pacific warm pool is analyzed in terms of its relation to the atmospheric Kelvin–Rossby wave, which dominates the large-scale flow during the austral summer. The study uses Doppler radar data collected by aircraft and ship radars during different time periods in the Tropical Ocean Global Atmosphere Coupled Ocean–Atmosphere Response Experiment to characterize the mesoscale circulations of organized convective cloud systems occurring throughout the season. ...
Tópico(s): Oceanographic and Atmospheric Processes
2000 - American Meteorological Society | Journal of the Atmospheric Sciences
Andrea Campos‐Serra, Sandra Montmany-Vioque, Pere Rebasa, Heura Llaquet Bayo, Raquel Gràcia-Roman, Anna Colom-Gordillo, Salvador Navarro‐Soto,
Las constantes vitales detectan la presencia de hemorragia al perder grandes cantidades de sangre, lo que comporta una gran morbimortalidad. El Shock Index (SI) es un parámetro que detecta el sangrado con puntos de corte de 0,9. El objetivo de este estudio es valorar si un punto de corte de ≥ 0,8 es más sensible para detectar sangrado oculto, permitiendo iniciar maniobras terapéuticas más precoces. Estudio analítico de validación del SI que incluye pacientes politraumatizados graves mayores de 16 años. ...
Tópico(s): Cardiac Arrest and Resuscitation
2018 - Elsevier BV | Cirugía Española
Andrea Campos‐Serra, Sandra Montmany-Vioque, Pere Rebasa, Heura Llaquet Bayo, Raquel Gràcia-Roman, Anna Colom-Gordillo, Salvador Navarro‐Soto,
Vital signs indicate the presence of bleeding only after large amounts of blood have been lost, with high morbidity and mortality. The Shock Index (SI) is a hemorrhage indicator with a cut-off point for the risk of bleeding at 0.9. The aim of this study is to assess whether a cut-off of ≥0.8 is more sensitive for detecting occult bleeding, providing for early initiation of therapeutic maneuvers. SI analytical validation study of severe trauma patients older than 16 years of age. Vital signs were recorded, ...
Tópico(s): Emergency and Acute Care Studies
2018 - Elsevier BV | Cirugía Española (English Edition)
D. Cotesta, Luigi Petramala, Valentina Serra, Sandra Giustini, Luigina Divona, Stefano Calvieri, Giorgio De Toma, Antonio Ciardi, Alessandro Corsi, Rita Massa, M. G. Reale, Claudio Letizia,
Pheochromocytomas are catecholamine-producing neuroendocrine tumours arising from chromaffin cells of the adrenal medulla or extra-adrenal paraganglionic system that show 2 distinctive features, rarity and clinical variability. Pheochromocytoma occasionally is associated with pathological lesions of the adrenal cortex. We present 2 cases of patients referred to our hospital with a finding of clinical suspected pheochromocytoma. Both of them were hypertensive; the first patient with typical symptoms ...
Tópico(s): Hormonal Regulation and Hypertension
2006 - Edizioni Minerva Medica | Minerva Endocrinologica
Analía V. Serra, Sandra E. Botté, Diana G. Cuadrado, Noelia S. La Colla, Vanesa L. Negrín,
Tópico(s): Mercury impact and mitigation studies
2017 - Springer Science+Business Media | Environmental Earth Sciences
Borja Quiroga, María José Soler, Alberto Ortíz, Carlos Jesús Jarava Mantecón, Virginia Olinda Gomes Pérez, A. Bordils, José Luis Lacueva, Antonio Franco, Pablo Delgado Conde, Patricia Muñoz Ramos, Carmen Calderón González, Juan Manuel Cazorla López, Jinny Sánchez-Rodríguez, Ana Sánchez Horrillo, Tania Monzón, Alba Leyva, José Antonio Muñoz Rojas, Ron T. Gansevoort, Patricia de Sequera, Maria Teresa Jaldo Rodríguez, Rafael Lucena Valverde, Marta Puerta Carretero, Mayra Ortega Díaz, Daniel Gaitán Tocora, Esther Rodriguez Suárez, Alfredo José Sáenz Santolaya, Patricia Arribas Cobo, Tamar Talavan, Raquel Cerrajero Calero, Carolina Gracia-Iguacel, Emilio González‐Parra, Mônica Corso Pereira, Catalina Martín-Cleary, Ana Ramos-Verde, Martín Giorgi, Sánchez González, Yohana Gil Giraldo, Ana Sánchez Horrillo, Pablo Ruano Suárez, Antonio Fernández Perpén, Andrés Fernández, Laura Salanova Villanueva, Alejandra Cortiñas, Pablo A Díez Arias, Alicia Cabrera Cárdenas, Antonio de Santos, Almudena Hernández Núñez, Guillermina Barril Cuadrado, Loreto Mariscal de Gante, Raquel Repollet, Concepción Redondo Polo, Francesc Moreso, María Azancot, Natàlia Ramos, Oriol Bestard Nestor Toapanta, Ignacio Cidraque, Sheila Bermejo, Irene Agraz, Oreto Prat, Carlota Medina, Emma Pardo, Oreto Prat, A. Sáiz, Maria Antònia Munar Vila, Secundino Cigarrán, Nicolás Menéndez Granados, María Jesús Corton Cabo, Walter López Alarcón, Soledad Pizarro Sánchez, Simona Alexandru, Laura García Puente Suarez, Saúl Pampa Saico, Marisol Poma Tapia, Rocío Zamora, Rosa Sánchez Hernández, Laura Rodríguez Osorio, Nuria Garcı́a-Fernández, Paloma Leticia Martin Moreno, Noelia Ania González, Ana Sabalza Ortiz, María Nieves Bastida Iñarrea, Sagrario Soriano Cabrera, Raquel Ojeda López, Cayetana Moyano Peregrí, M.L. Agüera, M.D. Navarro Cabello, Auxiliadora Mazuecos, Teresa Garcı́a, Carlos F. Narváez, Cristhian Orellana, Marı́a Gabriela Márquez, Carolina Lancho Novillo, Pedro Luis Quirós Ganga, Fernando Vallejo Carrión, Antonio Luis García Herrera, Natalia Blanco Castro, Rosa María Ruiz-Calero Cendrero, María Victoria Martín Hidalgo-Barquero, Román Hernández Gallego, Alvaro Goyoaga Alvarez, Eva Vázquez Leo, José Luis Pizarro León, Manuel Antonio Martínez García, Benaldina García Jiménez, Virginia Olinda Gómez Pérez, Juan de Dios Ramiro Moya, Diana López Espinosa, Alejandro Jiménez Herrador, Manuel Navarro Zurita, Leonardo Díaz Álvarez, ÁlvaroGonzález Martínez, Sandra Báez Arroyo, Raquel Reina Fernández, Marlyn Janella Suárez Vargas, Rocío Calurano Casero, Gustavo Useche, Amparo Bernat García, Ana Beatriz Muñoz Díaz, Carmen Santamaría de Miguel, Ángel Palacios, Brenda Henningsmeyer, Esther Orero Calve, José Lacueva Moya, Yurika Sato, Marta Serra Marín, Sandra Tejedor, Shaida Martínez Vaquera, Manuel Carnerero di Riso, Irene Torres, Georgina Alfaro, Olga Halauko, Fouad El Rifai, Ana Dolores Martínez, Pablo Justo Ávila, Ana Sánchez Horrillo, Marta Sanz Sainz, José María Baltar Martín, Laura García, José Luis Pérez Canga, Paola Milena Villabón Ochoa, Laura Muñiz Pacios, Lina León Machado, Augusto Quiroz Morales, Ignacio Manzur Cavalotti, Itziar Navarro Zorita, Sol Otero López, Sara Outon González, Carlos Soto Montañez, Auxiliadora Bajo Rubio, Gloria del Peso Gilsanz, Marta Ossorio Gonzalez, Rafael Sánchez, María O. López‐Oliva, Jesús Calviño Varela, Alba García Enríquez, Carmen Cobelo Casas, Pablo Otero Alonso, Lourdes González Tabarés, José María Lamas Barreiro, Luisa Palomares Solla, Arginino Gándara, Walfred Nájera de la Garza, Francisco Fernández Fleming, María Gloria Rodríguez Goyanes, Cintia Caramés Feijoo, María Mercedes Moreiras Plaza, Cristina Bayón Juan, Gabriel de Arriba, Katia Pérez del Valle, Francisco Contreras, Noelia Balibrea Lara, Dioné González Ferri, Eduardo Muñoz de Bustillo Llorente, Enriqueta González Rodríguez, Virginia Lopez De La Manzanara Perez, Marta Calvo Arevalo, José Antonio Herrero Calvo, María Rosario Llópez Carratalá, Leyre María Martin Rodríguez, Marisa Serrano Salazar, Begoña Prieto, José Pórtoles, Antonio Gil Paraíso, Emma Huarte, Maria Lanau, Rodrigo Avellaneda Campos, José Manuel Ubé, Isabel Berdud Godoy, Esther Torres Aguilera, Rolando Tello Alea, Margie Soledad Del Rosario Saldaña, Mercedes Salgueira, Nuria Aresté Fosalba, María de los Ángeles Rodríguez Gázquez, Rocío Collantes, Ana Isabel Ortega Martínez, María Jesús Moyano, Elena Jiménez Víbora, Sandra Castellano Gash, Lara Ruíz Martínez, María Cinta Aguilar Cervera, María Teresa Rodrigo De Tomas, Beatriz Azcue Prieto, Carmen Toyos, José Molina Del Rio, Adriana Restrepo Acosta, Amagoia Celayeta Zamacona, Ma Isabel Jimeno Martin, Saioa Bilbao Ortega, Ma Isabel Gallardo Ruiz, A Rubio, Paula Garcia Ledesma, Alvaro Goyoaga Alvarez, Esteban Poch, David Cucchiari, José Jesús Broseta, Beatriz Escamilla Cabrera, Aurelio Pastor Rodríguez Hernández, María Sagrario García Rebollo, Juana Margarita Rufino Hernández, Alejandra Yugueros González, J. C. Alonso, Amparo Martínez Más, Manuel Calvé, Marina Garces Cardona, Vanesa Canto Balaguer, José Ignacio Mínguela Pesquera, Eva Cotilla de la Rosa, David Rodríguez Santarelli, Alba Santos García, Antonio Cabezas Martin-Caro, Inmaculada Martinez Santamaria, Michal Červienka, Ana María Urraca de la Pisa, Lidia Sendino Monzon, Karina Ampuero Anachuri, Esther Hernández Garcia, Victoria Oviedo Gomez, Raquel Santana Estupiñán, Francisco Valga Amado, Patricia Pérez Borges, Marta Durán Beloso, Fernanda Arroyo Alonso, Noemí Pérez Felpete, Ana Meizoso Ameneiro, Mónica Cunha Mera, Beatriz Gil-Casares, Sofía Zárraga Larrondo, Naroa Maruki Kareaga, Ainhoa Inza San Salvador del Valle, Ana Rosa Muñoz García, Blanca Villacorta Linaza, Nuria del Toro Espinosa, Paola Estupiñan Perico, José Manuel Sánchez Oliva, Joaquín Manrique, I. Albo Castaño, Carolina Purroi, Nerea Gómez, Cristina Mansilla, Ane Utzurrum, Manuel Ramírez de Arellano Serna, Luis Guirado Perich, María Muñiz Rincón, Virginia Lopez De La Manzanara Perez, Marta Calvo Arevalo, José Antonio Herrero Calvo, Jesús Villoria, Alfonso Pobes Martínez De Salinas,
ABSTRACT Background There is scarce evidence on the fourth dose of severe acute respiratory syndrome coronavirus 2 vaccines in chronic kidney disease (CKD) patients. We evaluated the humoral response and effectivity of the fourth dose in the CKD spectrum: non-dialysis CKD (ND-CKD), haemodialysis (HD), peritoneal dialysis (PD) and kidney transplant (KT) recipients. Methods This is a prespecified analysis of the prospective, observational, multicentric SENCOVAC study. In patients with CKD who had received ...
Tópico(s): COVID-19 Impact on Reproduction
2022 - Oxford University Press | Nephrology Dialysis Transplantation
Andrew Foster, Roger Medina‐Serra, Sandra Sanchis‐Mora, Mark Plested, Thaleia‐Rengina Stathopoulou, Jaime Viscasillas,
Objective To describe a novel in-plane ultrasound (U/S)-guided temporal approach to peribulbar block in dogs. Study Design Prospective experimental cadaver study. Animals A group of 10 Beagle cadavers. Methods After describing the U/S anatomy, peribulbar injection was performed bilaterally in 10 thawed Beagle cadavers by two randomly assigned operators. A 5–8 MHz microconvex U/S probe was positioned caudal to the orbital ligament in the longitudinal plane. Using an in-plane technique, methylene blue ...
Tópico(s): Veterinary Equine Medical Research
2020 - Elsevier BV | Veterinary Anaesthesia and Analgesia
Jaume Francisco‐Pascual, Eduard Ródenas‐Alesina, Yassin Belahnech, Núria Rivas-Gándara, Jordi Pérez‐Rodon, Alba Santos‐Ortega, Begoña Benito, Ivo Roca‐Luque, Yolima Cossio‐Gil, Vicens Serra Garcia, Sandra Llerena-Butrón, Julián Rodríguez‐García, Àngel Moya‐Mitjans, David García‐Dorado, Ignacio Ferreira‐González,
Severe aortic stenosis (AoS) is considered a primary cause of syncope. However, other mechanisms may be present in these patients and accurate diagnosis can have important clinical implications. The aim of this study is to assess the different etiologies of syncope in patients with severe AoS and the impact on prognosis of attaining a certain or highly probable diagnosis for the syncope.Out of a cohort of 331 patients with AoS and syncope, 61 had severe AoS and were included in the study. Main cause ...
Tópico(s): Cardiac Arrhythmias and Treatments
2020 - Elsevier BV | Canadian Journal of Cardiology
Aleyda Benitez‐Amaro, Chiara Pallara, Laura Nasarre, Andrea Rivas-Urbina, Sònia Benı́tez, Àngela Vea, Olga Bornachea, David de Gonzalo‐Calvo, Gabriel Serra-Mir, Sandra Villegas, Roger Prades, Jose Luís Sánchez‐Quesada, Cristina Chiva, Eduard Sabidó, Teresa Tarragó, Vicenta Llorente‐Cortés,
Aggregated LDL is the first ligand reported to interact with the cluster II CR9 domain of low-density lipoprotein receptor-related protein 1 (LRP1).In particular, the C-terminal half of domain CR9, comprising the region Gly1127-Cys1140 exclusively recognizes aggregated LDL and it is crucial for aggregated LDL binding.Our aim was to study the effect of the sequence Gly1127-Cys1140 (named peptide LP3 and its retro-enantio version, named peptide DP3) on the structural characteristics of sphingomyelinase-( ...
Tópico(s): Proteins in Food Systems
2019 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Biomembranes
Danuta R. Gawel, Jordi Serra-Musach, Sandra Lilja, Jesper Aagesen, Àlex Arenas, B. Asking, Malin Bengnér, Janne Björkander, Sophie Biggs, Jan Ernerudh, Henrik Hjortswang, Jan‐Erik Karlsson, Mattias Köpsén, Eun Jung Lee, Antonio Lentini, Xinxiu Li, Mattias Magnusson, David Martínez-Enguita, Andreas Matussek, Colm E. Nestor, Samuel Schäfer, Oliver Seifert, Ceylan Sönmez, Henrik Stjernman, Andreas Tjärnberg, Simon Wu, Karin Åkesson, Alex K. Shalek, Margaretha Stenmarker, Huan Zhang, Mika Gustafsson, Mikael Benson,
Genomic medicine has paved the way for identifying biomarkers and therapeutically actionable targets for complex diseases, but is complicated by the involvement of thousands of variably expressed genes across multiple cell types. Single-cell RNA-sequencing study (scRNA-seq) allows the characterization of such complex changes in whole organs. The study is based on applying network tools to organize and analyze scRNA-seq data from a mouse model of arthritis and human rheumatoid arthritis, in order ...
Tópico(s): interferon and immune responses
2019 - BioMed Central | Genome Medicine
Produção Nacional
Revisado por pares
Matheus Roque, Karinna Lattes, Sandra Serra, Iván Solà, Selmo Geber, Ramón Carreras, Miguel Ángel Checa,
Objective To examine the available evidence to assess if cryopreservation of all embryos and subsequent frozen embryo transfer (FET) results in better outcomes compared with fresh transfer. Design Systematic review and meta-analysis. Setting Centers for reproductive care. Patient(s) Infertility patient(s). Intervention(s) An exhaustive electronic literature search in MEDLINE, EMBASE, and the Cochrane Library was performed through December 2011. We included randomized clinical trials comparing outcomes of ...
Tópico(s): Reproductive Biology and Fertility
2012 - Elsevier BV | Fertility and Sterility
Ruth Serra-Moreno, Sandra Acosta, Jean-Pierre Hernálsteens, Juan Jofre, Maite Muniesa,
Abstract Background The Red recombinase system of bacteriophage lambda has been used to inactivate chromosomal genes in E. coli K-12 through homologous recombination using linear PCR products. The aim of this study was to induce mutations in the genome of some temperate Shiga toxin encoding bacteriophages. When phage genes are in the prophage state, they behave like chromosomal genes. This enables marker genes, such as antibiotic resistance genes, to be incorporated into the stx gene. Once the phages' ...
Tópico(s): Escherichia coli research studies
2006 - Springer Science+Business Media | BMC Molecular Biology
Gemma Serra‐Bardenys, Sandra Peiró,
Oxidoreductases catalyze oxidation-reduction reactions and comprise a very large and diverse group of enzymes, which can be subclassified depending on the catalytic mechanisms of the enzymes. One of the most prominent oxidative modifications in proteins is carbonylation, which involves the formation of aldehyde and keto groups in the side chain of lysines. This modification can alter the local macromolecular structure of proteins, thereby regulating their function, stability, and/or localization, ...
Tópico(s): Redox biology and oxidative stress
2021 - Wiley | FEBS Journal
Alejandro R. Roda, Laia Montoliu‐Gaya, Gabriel Serra-Mir, Sandra Villegas,
Alzheimer's disease (AD) is the most common dementia worldwide. According to the amyloid hypothesis, the early accumulation of the Aβ-peptide triggers tau phosphorylation, synaptic dysfunction, and eventually neuronal death leading to cognitive impairment, as well as behavioral and psychological symptoms of dementia. ScFv-h3D6 is a single-chain variable fragment that has already shown its ability to diminish the amyloid burden in 5-month-old 3xTg-AD mice. However, tau pathology is not evident at ...
Tópico(s): Advanced Glycation End Products research
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Naomi Cano‐Ibáñez, Lluís Serra‐Majem, Sandra Martín‐Peláez, Miguel Ángel Martínez‐González, Jordi Salas‐Salvadó, Maria Dolores Corella Piquer, Camille Lassale, J. Alfredo Martínéz, Ángel M. Alonso‐Gómez, Julia Wärnberǵ, Jesús Vioqué, Dora Romaguera, José López‐Miranda, Ramón Estruch, Ana María Gómez-Pérez, José Manuel Santos‐Lozano, Fernando Fernández‐Aranda, Aurora Bueno‐Cavanillas, Josep A. Tur, Vicente Martín, Xavier Pintó, Miguel Delgado‐Rodríguez, Pilar Matía‐Martín, Josép Vidal, Jersy Cárdenas‐Salas, Lidia Daimiel, Emilio Ros, Pilar Buil‐Cosiales, Nerea Becerra‐Tomás, Carmen Sáiz, Miguel Ángel Muñoz, Itziar Abete, Lucas Tojal‐Sierra, Olga Fernández-Barceló, Andrea Bernabé-Casanova, Jadwiga Konieczna, Antoni Sureda, Rosa Casas, M. Rosa Bernal‐López, José Lapetra, Estefanía Toledo, Carlos Gómez Martínez, Óscar Coltell, Mireia Malcampo-Manrúbia, M. Ángeles Zulet, Carolina Sorto-Sánchez, Alfredo Gea, José Luís Hernández Fleta, Olga Castañer Niño, Almudena Sánchez‐Villegas,
Abstract The burden of depression is increasing worldwide, specifically in older adults. Unhealthy dietary patterns may partly explain this phenomenon. In the Spanish PREDIMED-Plus study, we explored (1) the cross-sectional association between the adherence to the Prime Diet Quality Score (PDQS), an a priori-defined high-quality food pattern, and the prevalence of depressive symptoms at baseline (cross-sectional analysis) and (2) the prospective association of baseline PDQS with changes in depressive ...
Tópico(s): Obesity, Physical Activity, Diet
2021 - Cambridge University Press | British Journal Of Nutrition
Elena Garralda, Marie‐Eve Beaulieu, Víctor Moreno, Sílvia Casacuberta‐Serra, Sandra Martínez-Martín, Laia Foradada, Guzmán Alonso, Daniel Massó-Vallés, Sergio López‐Estévez, Toni Jauset, E. Corral de la Fuente, Bernard Doger, Tatiana Hernández, Raquel Pérez-López, Oriol Arqués, Virginia Castillo Cano, Josefa Ruíz Morales, Jonathan R. Whitfield, Manuela Niewel, Laura Soucek, Emiliano Calvo,
Abstract Among the ‘most wanted’ targets in cancer therapy is the oncogene MYC, which coordinates key transcriptional programs in tumor development and maintenance. It has, however, long been considered undruggable. OMO-103 is a MYC inhibitor consisting of a 91-amino acid miniprotein. Here we present results from a phase 1 study of OMO-103 in advanced solid tumors, established to examine safety and tolerability as primary outcomes and pharmacokinetics, recommended phase 2 dose and preliminary signs ...
Tópico(s): Protein Degradation and Inhibitors
2024 - Nature Portfolio | Nature Medicine
Roger Verdaguer, Marçal Soler, Olga Serra, Aïda Garrote, Sandra Fernández-Piñán, Dolors Company-Arumí, Enriqueta Anticó, Marisa Molinas, Mercè Figueras,
Suberin and wax deposited in the cork (phellem) layer of the periderm form the lipophilic barrier that protects mature plant organs. Periderm lipids have been widely studied for their protective function with regards to dehydration and for how they respond to environmental stresses and wounding. However, despite advances in the biosynthetic pathways of suberin and associated wax, little is known about the regulation of their deposition. Here, we report on a potato NAC transcription factor gene, StNAC103, ...
Tópico(s): Plant Physiology and Cultivation Studies
2016 - Oxford University Press | Journal of Experimental Botany
Pierluigi Ciet, Goffredo Serra, Silvia Bertolo, Sandra Spronk, Mirco Ros, Francesco Fraioli, Serena Quattrucci, M. Baroukh Assael, Carlo Catalano, Fabio Pomerri, Harm A.W.M. Tiddens, Giovanni Morana,
Tópico(s): Neonatal Respiratory Health Research
2015 - Springer Science+Business Media | European Radiology
Massimiliano Comai, Mauro Dalla Serra, Manuela Coraiola, Sandra Werner, Didier A. Colin, H. Monteil, Gilles Prévost, Gianfranco Menestrina,
Summary Staphylococcal γ‐haemolysins are bicomponent toxins in a family including other leucocidins and α‐toxin. Two active toxins are formed combining HlgA or HlgC with HlgB. Both open pores in lipid membranes with conductance, current voltage characteristics and stability similar to α‐toxin, but different selectivity (cation instead of anion). Structural analogies between γ‐haemolysins and α‐toxin indicate the presence, at the pore entry, of a conserved region containing four positive charges in ...
Tópico(s): Bacterial Genetics and Biotechnology
2002 - Wiley | Molecular Microbiology
Tópico(s): Augustinian Studies and Theology
1999 - Fabrizio Serra Editore | Materiali e discussioni per l’analisi dei testi classici
Produção Nacional
Revisado por pares
Rodrigo F. Silva, Maria Elisabete Darbello Zaniquelli, Osvaldo Antônio Serra, Í. Torriani, Sandra G. Castro,
Abstract The interaction of trivalent europium and terbium ions with arachidic acid monolayers is reported. The ions are incorporated into the monolayer from the subphase solution, increasing the minimum area per molecule and modifying the pressure–area isotherms. Europium and terbium arachidate bonding in multilayer films transferred to solid supports is evidenced by FTIR and photophysical measurements. The luminescent films are `Y' type structures, as shown by the X-ray diffraction patterns.
Tópico(s): Lipid Membrane Structure and Behavior
1998 - Elsevier BV | Thin Solid Films
Ernestine Nicaise Djuidje, Elisa Durini, Sabrina Sciabica, Elena Serra, Jan Balzarini, Sandra Liekens, Stefano Manfredini, Silvia Vertuani, Anna Baldisserotto,
In the search for scaffolds for multifunctional compounds we investigated the structure activity relationship of a class of benzimidazole derivatives bearing 5-membered ring. The newly synthesized and the already known compounds were divided into three classes that present different substituent at 5 position of the benzimidazole ring (-H, -COOH or –SO3H) and different heterocycle at position 2 (thiophene, furan or pyrrole). All the derivatives were synthesized and tested to determine their photoprotective ...
Tópico(s): Plant chemical constituents analysis
2020 - Multidisciplinary Digital Publishing Institute | Molecules
Kazutoyo Osoegawa, Tamara Vayntrub, S. Wenda, Dianne De Santis, Konstantinos Barsakis, Milena Ivanova, Susan H. Hsu, Jonathan Barone, Rhonda Holdsworth, Mary Diviney, Medhat Askar, Amanda Willis, Dawn Railton, Sophie Laflin, Ketevan Gendzekhadze, Arisa Oki, Nicoletta Sacchi, Michela Mazzocco, Marco Andreani, Reem Ameen, Catherine Stavropoulos‐Giokas, Amalia Dinou, Margareth Afonso Torres, Rodrigo dos Santos Francisco, Carles Serra‐Pages, Damian Goodridge, Sandra Balladares, Maria Bettinotti, Brian Iglehart, Zahra Kashi, Russell K. Martin, Chee Loong Saw, Jiannis Ragoussis, Jonathan Downing, Cristina Navarrete, Winnie Chong, Katsuyuki Saito, Martin Petřek, Stana Tokić, Karin Padrós, Ma Beatriz Rodriguez, Viktoria Zakharova, Olga Shragina, Susana R. Marino, Nicholas K. Brown, Takashi Shiina, Shingo Suzuki, Eric Spierings, Qiuheng Zhang, Yuxin Yin, Gerald P. Morris, Ana Hernández, Phillip Ruiz, Seik‐Soon Khor, Katsushi Tokunaga, Aviva Geretz, Rasmi Thomas, Fumiko Yamamoto, Kalyan C. Mallempati, Sridevi Gangavarapu, Uma Kanga, Shweta Tyagi, Steven G. E. Marsh, Will P. Bultitude, Xiangjun Liu, Da-jiang Cao, Maarten Penning, Carolyn Katovich Hurley, Anne Cesbron, Claudia Mueller, Joannis Mytilineos, Eric T. Weimer, Mats Bengtsson, Gottfried Fischer, John A. Hansen, Chia-Jung Chang, Steven J. Mack, Lisa E. Creary, Marcelo Fernández-Viña,
The 17th International HLA and Immunogenetics Workshop (IHIW) organizers conducted a Pilot Study (PS) in which 13 laboratories (15 groups) participated to assess the performance of the various sequencing library preparation protocols, NGS platforms and software in use prior to the workshop. The organizers sent 50 cell lines to each of the 15 groups, scored the 15 independently generated sets of NGS HLA genotyping data, and generated "consensus" HLA genotypes for each of the 50 cell lines. Proficiency ...
Tópico(s): Immunotherapy and Immune Responses
2019 - Elsevier BV | Human Immunology
J. García-Serra, Juan Pablo Ramis, Sandra Simó, Xavier Joya, Simona Pichini, Oriol Vall, Óscar García‐Algar,
Detection of prenatal drug abuse exposure is essential to ensure an appropriate monitoring of affected children. A maternal questionnaire is not an efficient screening tool. The usefulness of maternal hair and meconium as biological materials to assess this exposure has been described in last few years. The aim of this study was to compare both these alternative biological materials for prenatal drug exposure detection in the third trimester of pregnancy, in order to assess its use as a screening ...
Tópico(s): Folate and B Vitamins Research
2012 - Elsevier BV | Anales de Pediatría
Antonio Sitges‐Serra, R Sánchez Hernández, Sandra Maestro, T. Pi-Suñer, Jose Maria Garces, Marcelo Segura,
The prevention of catheter sepsis lies in a sound understanding of the routes through which catheters get contaminated. The catheter hub has been recognized as a portal for microorganisms causing catheter sepsis, particularly in central venous catheters inserted for > 1 wk. Bacteria and fungi may reach the internal surface of the catheter connector during manipulation by hospital staff and then colonize the entire lumen of the catheter. Endoluminal contamination has diagnostic, therapeutic, and preventive ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1997 - Elsevier BV | Nutrition