M.C.G. Passeggi, L.I. Vergara, Sandra M. Mendoza, J. Ferrón,
Abstract Auger electron spectroscopy and ion sputtering depth profiling have been used to study Ti thin film oxidation and Ti–O 2 co-adsorption processes. The equilibrium oxide stoichiometry depends not only on the substrate temperature and interface effects, but also on the way the oxygen is incorporated. Heating the sample, either when the room temperature saturation has been achieved (post-oxidation), or from the beginning of the process, produces additional oxidation as compared to the room temperature ...
Tópico(s): Semiconductor materials and devices
2002 - Elsevier BV | Surface Science
Jérémy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina García-Prat, Lucy Bizien, Alba Parra-Martínez, Rui Yang, Liis Haljasmägi, Mélanie Migaud, Karita Särekannu, Julia Maslovskaja, Nicolas de Prost, Yacine Tandjaoui-Lambiotte, Charles‐Édouard Luyt, Blanca Amador-Borrero, Alexandre Gaudet, Julien Poissy, Pascal Morel, Pascale Richard, Fabrice Cognasse, Jesús Troya, Sophie Trouillet‐Assant, Alexandre Bélot, Kahina Saker, Pierre Garçon, Jacques G. Rivière, Jean‐Christophe Lagier, Stéphanie Gentile, Lindsey B. Rosen, Elana Shaw, Tomohiro Morio, Junko Tanaka, David Dalmau, Pierre‐Louis Tharaux, D. Sène, Alain Stépanian, Bruno Mégarbane, Vasiliki Triantafyllia, Arnaud Fekkar, James R. Heath, José Luis Franco, Juan‐Manuel Anaya, Jordi Solé‐Violán, Luisa Imberti, Andrea Biondi, Paolo Bonfanti, Riccardo Castagnoli, Ottavia M. Delmonte, Yu Zhang, Andrew L. Snow, Steven M. Holland, Catherine M. Biggs, Marcela Moncada‐Vélez, Andrés A. Arias, Lazaro Lorenzo, Soraya Boucherit, Dany Anglicheau, Anna M. Planas, Filomeen Haerynck, Sotiriјa Duvlis, Tayfun Özçelık, Sevgi Keleş, Ahmed Aziz Bousfiha, Jalila El Bakkouri, Carolina Ramírez‐Santana, Stéphane Paul, Qiang Pan‐Hammarström, Lennart Hammarström, Annabelle Dupont, Alina Kurolap, Christine N. Metz, Alessandro Aiuti, Giorgio Casari, Vito Lampasona, Fabio Ciceri, Lucila Akune Barreiros, Elena Domínguez‐Garrido, Mateus Vidigal, Mayana Zatz, Diederik van de Beek, Sabina Sahanic, Ivan Tancevski, Yuriy Stepanovskyy, Oksana Boyarchuk, Yoko Nukui, Miyuki Tsumura, Loreto Vidaur, Stuart G. Tangye, Sonia Burrel, Darragh Duffy, Lluís Quintana‐Murci, Adam Klocperk, Nelli Y. Kann, Anna Shcherbina, YL Lau, Daniel Leung, Matthieu Coulongeat, Julien Marlet, Rutger Koning, Luis Felipe Reyes, Angélique Chauvineau‐Grenier, Fabienne Venet, Guillaume Monneret, Michel C. Nussenzweig, Romain Arrestier, Idris Boudhabhay, Hagit Baris Feldman, David Hagin, Joost Wauters, Isabelle Meyts, Adam H. Dyer, Seán Kennelly, Nollaig M. Bourke, Rabih Halwani, Fatemeh Saheb Sharif‐Askari, Karim Dorgham, Jérôme Sallette, Souad Mehlal Sedkaoui, Suzan A. AlKhater, Raúl Rigo‐Bonnin, Francisco Morandeira, Lucie Roussel, Donald C. Vinh, Christian Erikstrup, Antônio Condino‐Neto, Carolina Prando, Анастасія Бондаренко, András N. Spaan, Laurent Gilardin, Jacques Fellay, Stanislas Lyonnet, Kaya Bilgüvar, Richard P. Lifton, Shrikant Mane, Mark S. Anderson, Bertrand Boisson, Vivien Béziat, Shen‐Ying Zhang, Evangelos Andreakos, Olivier Hermine, Aurora Pujol, Pärt Peterson, Trine H. Mogensen, Lee Rowen, James Mond, Stéphanie Debette, Xavier de Lamballerie, Charles Burdet, Lila Bouadma, Marie Zins, Pere Soler‐Palacín, Roger Colobrán, Guy Gorochov, Xavier Solanich, Sophie Susen, Javier Martínez‐Picado, Didier Raoult, Marc Vasse, Peter K. Gregersen, Lorenzo Piemonti, Carlos Rodríguez‐Gallego, Luigi D. Notarangelo, Helen C. Su, Kai Kisand, Satoshi Okada, Anne Puel, Emmanuelle Jouanguy, Charles M. Rice, Pierre Tiberghien, Qian Zhang, Jean‐Laurent Casanova, Laurent Abel, Aurelié Cobat, Peng Zhang, Yoann Seeleuthner, Estelle Talouarn, Astrid Marchal, Daniela Matuozzo, Aliénor de la Chapelle, Jie Chen, Maya Chrabieh, Dana Liu, Yelena Nemirowskaya, Inés Marín Cruz, Marie Materna, Sophie Pelet, C Thibault, Xiaogang Li, Jorge Abad, Giulia Accordino, Cristian Achille, Sergio Aguilera, Aina Aguiló‐Cucurull, Alessandro Aiuti, Esra Akyüz Özkan, Ilad Alavi Darazam, Jonathan Antonio Roblero Albisures, Juan C. Aldave, Miquel Alfonso Ramos, Sajid Ali, Anna Aliberti, Seyed Alireza Nadji, Gülsüm Alkan, Suzan A. AlKhater, Jérôme Allardet-Servent, Luís M. Allende, Rebeca Alonso‐Arias, Mohammed Alshahrani, Laia Alsina, Marie‐Alexandra Alyanakian, Blanca Amador Borrero, Zahir Amoura, Arnau Antolí, Romain Arrestier, Mélodie Aubart, Teresa Auguet, Iryna Avramenko, Gökhan Aytekіn, Axelle Azot, Seiamak Bahram, Fanny Bajolle, Fausto Baldanti, Aurélie Baldolli, Mayte Ballester, Hagit Baris Feldman, Benoı̂t Barrou, Federica Barzaghi, Sabrina Basso, Gülsüm İclal Bayhan, Alexandre Bélot, Liliana Bezrodnik, Agurtzane Bilbao, Géraldine Blanchard-Rohner, Ignacio Blanco, Adeline Blandinières, Daniel Blázquez‐Gamero, Alexandre Bleibtreu, Markéta Bloomfield, Mireia Bolívar-Prados, Анастасія Бондаренко, A. Borghesi, Raphaël Borie, Elisabeth Botdhlo-Nevers, Ahmed Aziz Bousfiha, Aurore Bousquet, David Boutolleau, Claire Bouvattier, Oksana Boyarchuk, Juliette Bravais, M. Luisa Briones, Marie-Eve Brunner, Raffaele Bruno, Maria Rita Passos‐Bueno, Huda Bukhari, Jacinta Bustamante, Juan José Cáceres Agra, Ruggero Capra, Raphaël Carapito, Maria Carrabba, Giorgio Casari, Carlos Casasnovas, Marion Caséris, Irene Cassaniti, Martin Castelle, Francesco Castelli, Martín Castillo de Vera, Mateus Vidigal de Castro, Émilie Catherinot, Jale Bengi Çelik, Alessandro Ceschi, Martin Chalumeau, Bruno Charbit, Matthew Pellan Cheng, Père Clavé, Bonaventura Clotet, Anna Codina, Yves Cohen, Roger Colobrán, Cloé Comarmond, Alain Combes, Patrizia Comoli, Angelo Guido Corsico, Taner Çoşkuner, Aleksandar Cvetkovski, Cyril Cyrus, David Dalmau, François Danion, D.R. Darley, Vincent Das, Nicolás Dauby,
Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general ...
National Academy of Sciences
Antonio Pani, Giuseppina Belotti, Carlo Bonanno, Maria Grazia Bongiorni, Nicola Bottoni, Roberta Brambilla, Sergio De Ceglia, Paolo Della Bella, G De Vito, Daniele Malaspina, Endrj Menardi, Velia Napoli, Maria Silvia Negroni, Salvatore Ocello, Daniela Orsida, Claudio Pandozi, Stefano Pedretti, Diego Penela, Patrizia Pepi, Luca Rossi, Giovanni Rovaris, Alice Scopinaro, Antonello Vincenti, Graziana Viola, Valerio Zacà, Franco Zoppo, Pasquale Vergara, Sandra Badolati, Claudia Baiocchi, S. Belletti, Andrea Di Cori, Marco Galeazzi, Edoardo Gandolfi, Matteo Iori, Francesco Isola, Riccardo Massa, Giovanni Motta, Massimo Pala, Elena Piazzi, Fabio Quartieri, Luca Segreti, Antonello Vado, Gabriele Vignati,
Background: This multicenter, prospective study evaluated the determinants of zero-fluoroscopy (ZFL) ablation of supraventricular tachycardias. Methods and Results: Four hundred thirty patients (215 male, 55.4±22.1 years) with indication to electrophysiological study or ablation of supraventricular tachycardias were enrolled. All participating physicians agreed to follow the as low as reasonably achievable policy. A procedure was defined as ZFL when no fluoroscopy was used. The total fluoroscopy time ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2018 - Lippincott Williams & Wilkins | Circulation Arrhythmia and Electrophysiology
Guido Juckeland, Óscar Hernández, Arpith C. Jacob, Daniel Neilson, Verónica Melesse Vergara, Sandra Wienke, Alexander Bobyr, William C. Brantley, Sunita Chandrasekaran, Mathew Colgrove, Alexander Grund, Robert Henschel, Wayne Joubert, Matthias Müller, Dave Raddatz, Pavel Shelepugin, Brian Whitney, Bo Wang, Kalyan Kumaran,
Current and next generation HPC systems will exploit accelerators and self-hosting devices within their compute nodes to accelerate applications. This comes at a time when programmer productivity and the ability to produce portable code has been recognized as a major concern. One of the goals of OpenMP and OpenACC is to allow the user to specify parallelism via directives so that compilers can generate device specific code and optimizations. However, the challenge of porting codes becomes more complex ...
Tópico(s): Distributed and Parallel Computing Systems
2016 - Springer Science+Business Media | Lecture notes in computer science
M. Canales-Vergara, Sandra Valenzuela Süazo, Tatiana Paravic‐Klijn,
Nursing professionals make a large personnel segment which, doubtless, accomplishes an essential role in hospital and primary attention services. However, little is known about their working conditions and the implied occupational risks. Objective: To identify the working conditions and the reasons why nursing professionals in Chile become sick. Method: This is a systematic review with a descriptive and retrospective character performed through a systematic search in accordance to the Occupational ...
Tópico(s): Healthcare professionals’ stress and burnout
2016 - National Autonomous University of Mexico | Enfermería Universitaria
Du-San Baek, Ye‐Jin Kim, Sandra Vergara, Alex Conard, Cynthia Adams, Guillermo Calero, Rieko Ishima, John W. Mellors, Dimiter S. Dimitrov,
Neuro-endocrine prostate cancer (NEPC) accounts for about 20% of lethal metastatic castration-resistant prostate cancer (CRPC). NEPC has the most aggressive biologic behavior of all prostate cancers and is associated with poor patient outcome. Effective treatment for NEPC is not available because NEPC exhibit distinct cell-surface expression profiles compared to other types of prostate cancer. Recently, the carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (known as CEA or CD66e) was ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2021 - Elsevier BV | Cancer Letters
Zhuolun Shen, Yufei Xiang, Sandra Vergara, Apeng Chen, Zhengyun Xiao, Ulises Santiago, Changzhong Jin, Zhe Sang, Jiadi Luo, Kong Chen, Dina Schneidman‐Duhovny, Carlos J. Camacho, Guillermo Calero, Baoli Hu, Yi Shi,
Therapeutic and diagnostic efficacies of small biomolecules and chemical compounds are hampered by suboptimal pharmacokinetics. Here, we developed a repertoire of robust and high-affinity antihuman serum albumin nanobodies (NbHSA) that can be readily fused to small biologics for half-life extension. We characterized the thermostability, binding kinetics, and cross-species reactivity of NbHSAs, mapped their epitopes, and structurally resolved a tetrameric HSA-Nb complex. We parallelly determined the ...
Tópico(s): Protein purification and stability
2021 - Cell Press | iScience
Produção Nacional
Juan A. Sánchez, Luisa F. Dueñas, Sonia J. Rowley, Fanny L. González-Zapata, Diana Carolina Vergara-Florez, Sandra M. Montaño-Salazar, Iván Calixto-Botía, Carlos E. Gómez, Rosalinda Abeytia, Patrick L. Colin, Ralf T. S. Cordeiro, Carlos Daniel Pérez,
Mesophotic gorgonian corals comprise a polyphyletic group of octocorals mostly with a proteinaceous branching axial skeleton. Dense assemblages of gorgonian corals usually dominate the seascape in mesophotic coral ecosystems (MCEs). In this chapter, we review the mesophotic gorgonian coral biodiversity, followed by a synthesis of the ecological implications of inhabiting this environment, as well as the threats that these communities face. MCEs include ~87 gorgonian corals genera distributed worldwide, ...
Tópico(s): Ocean Acidification Effects and Responses
2019 - Springer International Publishing | Coral reefs of the world
Sandra Vergara, Ulises Santiago, Chanaka Kumara, Diego Alducin, Robert L. Whetten, Miguel José Yácaman, Amala Dass, Arturo Ponce,
Metallic nanoparticles display unique optical, electronic, and chemical properties compared to their bulk counterparts. These properties are influenced by the internal structure of nanoparticles. Therefore, atomic structural characterization of nanoparticles is of paramount importance in nanotechnology. In this work, we present the synthesis, mass spectrometry, and structural characterization of highly monodisperse thiolate-protected gold nanoparticles (∼3.8 nm) using aberration-corrected scanning ...
Tópico(s): nanoparticles nucleation surface interactions
2018 - American Chemical Society | The Journal of Physical Chemistry C
Antonia María Romero, Mar Martínez-Pastor, Gang Du, Carme Solé, Carlos María, Sandra Vergara, Nerea Sanvisens, James A. Wohlschlegel, David P. Toczyski, Francesc Posas, Eulàlia de Nadal, María Teresa Martínez‐Pastor, Dennis J. Thiele, Sergi Puig,
Iron is an indispensable micronutrient for all eukaryotic organisms due to its participation as a redox cofactor in many metabolic pathways. Iron imbalance leads to the most frequent human nutritional deficiency in the world. Adaptation to iron limitation requires a global reorganization of the cellular metabolism directed to prioritize iron utilization for essential processes. In response to iron scarcity, the conserved Saccharomyces cerevisiae mRNA-binding protein Cth2, which belongs to the tristetraprolin ...
Tópico(s): RNA modifications and cancer
2018 - American Society for Microbiology | mBio
Sandra Vergara, Dylan A. Lukes, Michael W. Martynowycz, Ulises Santiago, Germán Plascencia‐Villa, Simon C. Weiss, M. Jason de la Cruz, David M. Black, Marcos M. Alvarez, Xóchitl López-Lozano, Christopher O. Barnes, Guowu Lin, Hans‐Christian Weissker, Robert L. Whetten, Tamir Gonen, Miguel José Yácaman, Guillermo Calero,
Solving the atomic structure of metallic clusters is fundamental to understanding their optical, electronic, and chemical properties. Herein we present the structure of the largest aqueous gold cluster, Au
Tópico(s): Gold and Silver Nanoparticles Synthesis and Applications
2017 - American Chemical Society | The Journal of Physical Chemistry Letters
Gustavo Plaza‐Manzano, Marta Vergara-Vila, Sandra Val-Otero, Cristina Rivera-Prieto, Daniel Pecos‐Martín, Tomás Gallego‐Izquierdo, Alejandro Ferragut‐Garcías, Natalia Romero‐Franco,
Recurrent ankle sprains often involve residual symptoms for which subjects often perform proprioceptive or/and strengthening exercises. However, the effectiveness of mobilization to influence important nerve structures due to its anatomical distribution like tibial and peroneal nerves is unclear. To analyze the effects of proprioceptive/strengthening exercises versus the same exercises and manual therapy including mobilizations to influence joint and nerve structures in the management of recurrent ...
Tópico(s): Sports injuries and prevention
2016 - Elsevier BV | Manual Therapy
Giorgio Vergara Caffarelli, Sandra Carillo, V. Valente,
The existence and uniqueness of solution to a one-dimensional hyperbolic problem arising in viscoelasticity is here considered. Specifically, the case of a singular kernel is analyzed. This choice is suggested by applications according to the literature to model a wider variety of materials.
Tópico(s): Advanced Mathematical Modeling in Engineering
2013 - Khayyam Publishing | Differential and Integral Equations
Mar Martínez-Pastor, Sandra Vergara, Sergi Puig, Dennis J. Thiele,
Iron (Fe) is an essential element for all eukaryotic organisms because it functions as a cofactor in a wide range of biochemical processes. Cells have developed sophisticated mechanisms to tightly control Fe utilization in response to alterations in cellular demands and bioavailability. In response to Fe deficiency, the yeast Saccharomyces cerevisiae activates transcription of the CTH1 and CTH2 genes, which encode proteins that bind to AU-rich elements (AREs) within the 3' untranslated regions (3'UTRs) ...
Tópico(s): Plant Micronutrient Interactions and Effects
2013 - Taylor & Francis | Molecular and Cellular Biology
Sandra Vergara, Sergi Puig, Dennis J. Thiele,
The yeast Cth2 protein is a CX8CX5CX3H tandem zinc finger protein that binds AU-rich element (ARE)-containing transcripts to enhance their decay in response to iron (Fe) deficiency. Mammalian members of this family of proteins are known to undergo nucleocytoplasmic shuttling, but little is known about the role of shuttling in the mechanism of ARE-dependent mRNA decay. Here we demonstrate that, like its mammalian homologues, Cth2 is a nucleocytoplasmic shuttling protein whose nuclear export depends ...
Tópico(s): RNA and protein synthesis mechanisms
2010 - Taylor & Francis | Molecular and Cellular Biology
Jianping Zuo, Sandra Vergara, Shinya Kohno, L. Shannon Holliday,
SUMMARY Vacuolar H+-ATPase (V-ATPase) is a fundamentally important enzyme in eukaryotic cells that is responsible for acidification of endocytic compartments. The B subunits of V-ATPases from mammals and tobacco hornworm have been shown to bind actin filaments. Actin-binding activity by the B subunit is required for targeting V-ATPases to the plasma membrane of osteoclasts. Bacterially expressed B subunit from the yeast Saccharomyces cerevisiae bound actin filaments with a Kd of 195 nmol l–1. The ...
Tópico(s): Metalloenzymes and iron-sulfur proteins
2008 - The Company of Biologists | Journal of Experimental Biology
Sergi Puig, Sandra Vergara, Dennis J. Thiele,
Iron (Fe) is an essential cofactor for a wide range of cellular processes. We have previously demonstrated in yeast that Cth2 is expressed during Fe deficiency and promotes degradation of a battery of mRNAs leading to reprogramming of Fe-dependent metabolism and Fe storage. We report here that the Cth2-homologous protein Cth1 is transiently expressed during Fe deprivation and participates in the response to Fe deficiency through the degradation of mRNAs primarily involved in mitochondrially localized ...
Tópico(s): Iron Metabolism and Disorders
2008 - Cell Press | Cell Metabolism
Sandra Vergara, Dennis J. Thiele,
Saccharomyces cerevisiae (baker's yeast) is an excellent model for understanding fundamental biological mechanisms that are conserved in Nature and that have an impact on human disease. The metal iron is a redox-active cofactor that plays critical biochemical roles in a broad range of functions, including oxygen transport, mitochondrial oxidative phosphorylation, chromatin remodelling, intermediary metabolism and signalling. Although iron deficiency is the most common nutritional disorder on the ...
Tópico(s): RNA modifications and cancer
2008 - Portland Press | Biochemical Society Transactions
Elisa Pedro-Segura, Sandra Vergara, Susana Rodrı́guez-Navarro, Roy Parker, Dennis J. Thiele, Sergi Puig,
Iron is an essential nutrient that participates as a redox co-factor in a broad range of cellular processes. In response to iron deficiency, the budding yeast Saccharomyces cerevisiae induces the expression of the Cth1 and Cth2 mRNA-binding proteins to promote a genome-wide remodeling of cellular metabolism that contributes to the optimal utilization of iron. Cth1 and Cth2 proteins bind to specific AU-rich elements within the 3'-untranslated region of many mRNAs encoding proteins involved in iron- ...
Tópico(s): RNA and protein synthesis mechanisms
2008 - Elsevier BV | Journal of Biological Chemistry
Ming Lu, Sandra Vergara, Li Zhang, L. Shannon Holliday, John P. Aris, Stephen L. Gluck,
Vacuolar H + -ATPases (V-ATPases) are highly conserved proton pumps that couple hydrolysis of cytosolic ATP to proton transport out of the cytosol. Although it is generally believed that V-ATPases transport protons by a rotary catalytic mechanism analogous to that used by F 1 F 0 -ATPases, the structure and subunit composition of the central or peripheral stalk of the multisubunit complex are not well understood. We searched for proteins that bind to the E subunit of V-ATPase using the yeast two-hybrid ...
Tópico(s): Metalloenzymes and iron-sulfur proteins
2002 - Elsevier BV | Journal of Biological Chemistry
Produção Nacional
Revisado por pares
M. Mozammel Hoque, Sandra Vergara, Partha Pratim Das, D. Ugarte, Ulises Santiago, Chanaka Kumara, Robert L. Whetten, Amala Dass, Arturo Ponce,
Atomic pair distribution function (PDF) analysis has been widely used to investigate nanocrystalline and structurally disordered materials. Experimental PDFs retrieved from electron diffraction (ePDF) in transmission electron microscopy (TEM) represent an attractive alternative to traditional PDF obtained from synchrotron X-ray sources, particularly for studying minute samples. Nonetheless, the inelastic scattering produced by the large dynamical effects of electron diffraction may obscure the interpretation ...
Tópico(s): Gold and Silver Nanoparticles Synthesis and Applications
2019 - American Chemical Society | The Journal of Physical Chemistry C
Jianping Zuo, Jin Jiang, Shih-Hua Chen, Sandra Vergara, Yan Gong, Jing Xue, Haobo Huang, Masato Kaku, L. Shannon Holliday,
Abstract Adeno-associated virus was used to transduce primary mouse osteoclasts with the B1 isoform of vacuolar H+-ATPase. B1, which is not normally expressed in osteoclasts, was correctly targeted to ruffled membranes of resorbing osteoclasts. Mutant subunit B1 that lacked a functional actin-binding site did not accumulate in ruffled membranes. Introduction: The B1 “kidney” and B2 “brain” isoforms of subunit B of vacuolar H+-ATPase (V-ATPase) have actin binding sites that mediate interactions between ...
Tópico(s): RNA Interference and Gene Delivery
2006 - Oxford University Press | Journal of Bone and Mineral Research
Francisco Javier Alvarez-Cirerol, Marco Antonio López‐Torres, Ericka Rodríguez-León, César Rodríguez-Beas, Aarón Martínez‐Higuera, Humberto H. Lara, Sandra Vergara, M. Josefina Arellano-Jiménez, Eduardo Larios-Rodríguez, Marcel Martínez‐Porchas, Enrique de la Vega, Ramón Íñiguez-Palomares,
Early Mortality Syndrome (EMS) or Acute Hepatopancreatic Necrosis Syndrome (AHPNS) is a disease produced by gram-negative bacteria Vibrio parahaemolyticus ( V. parahaemolyticus ), which has caused declines in worldwide production of a white shrimp Litopenaeus vannamei ( L. vannamei ). In this work, we propose the implementation of silver nanoparticles (AgNPs) synthesized with Rumex hymenosepalus (Rh) extract as an alternative on V. parahaemolyticus control. AgNPs were characterized by UV-Vis spectroscopy, scanning ...
Tópico(s): Aquatic life and conservation
2019 - Hindawi Publishing Corporation | Journal of Nanomaterials
HW Millie Fung, Traci J.T. Mikasa, Julie Vergara, Sandra J. Sivananthan, Jeffrey A. Guderian, Malcolm S. Duthie, Thomas S. Vedvick, Christopher B. Fox,
Nanosuspensions are an important class of delivery system for vaccine adjuvants and drugs. Previously, we developed a nanosuspension consisting of the synthetic TLR4 ligand glucopyranosyl lipid adjuvant (GLA) and dipalmitoyl phosphatidylcholine (DPPC). This nanosuspension is a clinical vaccine adjuvant known as GLA-AF. We examined the effects of DPPC supplier, buffer composition, and manufacturing process on GLA-AF physicochemical and biological activity characteristics. DPPC from different suppliers ...
Tópico(s): Immunotherapy and Immune Responses
2013 - BioMed Central | Journal of Nanobiotechnology
Carmelo Morales‐Angulo, Sandra Vergara Pastrana, Sergio Obeso-Agüera, Leticia Acle Cervera, Miguel Á. González‐Gay,
Behçet disease (BD) is a systemic immune-mediated vasculitis of unknown origin characterised by recurrent orogenital ulceration, ocular inflammation and skin lesions. The aim of our study was to identify ear, nose and throat (ENT) manifestations associated with BD.Retrospective review of the medical records of all patients diagnosed with BD who attended a tertiary public hospital in Cantabria (Spain) over a period of 22 years. Clinical manifestations, in particular those concerning ENT, were retrieved ...
Tópico(s): Retinal and Optic Conditions
2013 - Elsevier BV | Acta Otorrinolaringológica Española
M. Canales-Vergara, Sandra Valenzuela Süazo, L.H. Luengo-Machuca,
Objetivo: Medir la Calidad de Vida en el trabajo (CVT) y sus factores asociados en profesores de colegios públicos de Concepción, Chile. Método: Investigación cuantitativa, transversal, descriptiva. Muestra: 92 profesores. Instrumentos: Se empleó CVT-GOHISALO para evaluar CVT (Alpha de Cronbach 0.952) y un cuestionario biosociodemográfico diseñado por el primer autor. El procesamiento de datos se realizó con SPPS, empleándose Rho-Spearman, Rho-Pearson, ANOVA y pruebas no-paramétricas. Se contó con ...
Tópico(s): Workplace Health and Well-being
2018 - National Autonomous University of Mexico | Enfermería Universitaria
Sandra Vergara-Perez, Marcelo Marucho,
One of the most used and efficient approaches to compute electrostatic properties of biological systems is to numerically solve the Poisson–Boltzmann (PB) equation. There are several software packages available that solve the PB equation for molecules in aqueous electrolyte solutions. Most of these software packages are useful for scientists with specialized training and expertise in computational biophysics. However, the user is usually required to manually take several important choices, depending ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2015 - Elsevier BV | Computer Physics Communications
Miguel Hadzich, François Veynandt, Julien Delcol, Luis Miguel Hadzich, Juan Pablo Pérez, Sandra Vergara,
Coffee is the first agricultural exportation product of Peru. Most of the added value is in the roasting process, which is usually done abroad. Concentrating solar energy provides a sustainable, clean and affordable mean of roasting coffee locally. The producers' income could be improved with such a technology, enhancing their quality of life. The design of a solar coffee roaster is detailed in this research work. The open-source Scheffler solar reflector is used to concentrate light on a roasting ...
Tópico(s): Coffee research and impacts
2014 - Elsevier BV | Energy Procedia
Alex J. Guseman, Linda J. Rennick, Sham Nambulli, Chandra Nath Roy, David R. Martinez, Darian T. Yang, Fatema Bhinderwala, Sandra Vergara, Alexandra Schaefer, Ralph S. Baric, Zandrea Ambrose, W. Paul Duprex, Angela M. Gronenborn,
SARS-CoV-2 spike harbors glycans which function as ligands for lectins. Therefore, it should be possible to exploit lectins to target SARS-CoV-2 and inhibit cellular entry by binding glycans on the spike protein. Burkholderia oklahomensis agglutinin (BOA) is an antiviral lectin that interacts with viral glycoproteins via N-linked high mannose glycans. Here, we show that BOA binds to the spike protein and is a potent inhibitor of SARS-CoV-2 viral entry at nanomolar concentrations. Using a variety ...
Tópico(s): Complement system in diseases
2023 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Carmelo Morales‐Angulo, Sandra Vergara Pastrana, Sergio Obeso-Agüera, Leticia Acle Cervera, Miguel Á. González‐Gay,
Behçet's disease (BD) is a systemic immune-mediated vasculitis of unknown origin characterised by recurrent orogenital ulceration, ocular inflammation and skin lesions. The aim of our study was to identify ear, nose and throat (ENT) manifestations associated with BD. Retrospective review of the medical records of all patients diagnosed with BD who attended a tertiary public hospital in Cantabria (Spain) over a period of 22 years. Clinical manifestations, in particular those concerning ENT, were retrieved ...
Tópico(s): Cerebral Venous Sinus Thrombosis
2014 - Elsevier BV | Acta Otorrinolaringologica (English Edition)