Volker Hagen, Brigitte Dekowski, Vasilica Nache, Reinhard Schmidt, Daniel Geißler, Dorothea Lorenz, Jenny Eichhorst, Sandro Keller, Hiroshi Kaneko, Klaus Benndorf, Burkhard Wiesner,
Entschützung mit dem Reagens Licht: Cyclische Nucleosidmonophosphate (cNMPs) können durch Ein- und Zweiphotonenphotolyse photolabiler Cumarinylmethylester von cAMP und cGMP (A=Adenosin, G=Guanosin) sowie der 8-Brom-substitutierten Derivate effizient freigesetzt werden. Die Phototrigger zeichnen sich durch eine hohe Löslichkeit in Wasser aus und ermöglichen raum- und zeitaufgelöste Studien der molekularen Mechanismen von Prozessen, die durch cyclische Nucleotide gesteuert werden. Hintergrundinformationen ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2005 - Wiley | Angewandte Chemie
Volker Hagen, Brigitte Dekowski, Vasilica Nache, Reinhard Schmidt, Daniel Geißler, Dorothea Lorenz, Jenny Eichhorst, Sandro Keller, Hiroshi Kaneko, Klaus Benndorf, Burkhard Wiesner,
Shedding light: Efficient activation of cyclic nucleoside monophosphates (cNMPs) can be achieved upon one- and two-photon flash photolysis of novel photolabile coumarinylmethyl esters of cAMP and cGMP (A=adenosine, G=guanosine) as well as their 8-bromo-substituted derivatives. The phototriggers show high solubility in water and permit space- and time-resolved investigations of the molecular mechanisms of cyclic nucleotide dependent processes. Supporting information for this article is available on ...
Tópico(s): Radical Photochemical Reactions
2005 - Wiley | Angewandte Chemie International Edition
Mónika Molnár, Sandro Parisi, Yoshito Kakihara, Hiroshi Nojima, Ayumu Yamamoto, Yasushi Hiraoka, Anikó Bozsik, Matthias Sipiczki, Jürg Kohli,
Abstract rec7 is involved in intra- and intergenic meiotic recombination in all tested regions of the genome of the fission yeast Schizosaccharomyces pombe. Segregational analysis in a rec7 gene disruption mutant revealed frequent occurrence of two-spored asci. Spores giving rise to diploid colonies were shown to derive from skipping of the second meiotic division. Nondisjunction of homologous chromosomes at the first meiotic division was also frequent. The cytological structures and processes, ...
Tópico(s): Microtubule and mitosis dynamics
2001 - Oxford University Press | Genetics
Produção Nacional
Revisado por pares
Andrea Chiuri, Valeria Rosati, Giuseppe Vallone, S. Pádua, Hiroshi Imai, Sandro Giacomini, Chiara Macchiavello, Paolo Mataloni,
We present the experimental realization of the optimal estimation protocol for a Pauli noisy channel. The method is based on the generation of 2-qubit Bell states and the introduction of quantum noise in a controlled way on one of the state subsystems. The efficiency of the optimal estimation, achieved by a Bell measurement, is shown to outperform quantum process tomography.
Tópico(s): Quantum Mechanics and Applications
2011 - American Physical Society | Physical Review Letters
Sandro Betocchi, Hess Om, Maria Angela Losi, Hiroshi Nonogi, H P Krayenbuehl,
BACKGROUND Nonuniformity is a determinant of diastolic function. In patients with hypertrophic cardiomyopathy, hypertrophy, abnormal calcium handling, and regional ischemia can also play a role. This study was designed to assess regional mechanics, asynchrony, and asynergy in patients with hypertrophic cardiomyopathy. METHODS AND RESULTS Nine control subjects and 22 patients with hypertrophic cardiomyopathy were studied by biplane left ventriculography and high-fidelity pressure tracings for the ...
Tópico(s): Cardiovascular Effects of Exercise
1993 - Lippincott Williams & Wilkins | Circulation
Nick Craddock, Gillian Spurlock, Peter McGuffin, Michael J. Owen, Marika Nosten‐Bertrand, Frank Bellivier, Rolando Meloni, Marion Leboyer, Jacques Mallet, Lesley Mynett‐Johnson, V. Murphy, Patrick O. McKeon, George Kirov, John Powell, Hiroshi Kunugi, David Collier, Monica Larosa, Benedetta Nacmias, Sandro Sorbi, Sibylle G. Schwab, Manfred Ackenheil, Wolfgang Maier,
Background There is compelling evidence for the existence of susceptibility genes for bipolar disorder. Association studies using functional DNA variations are an important approach for identifying these genes. The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters and is a candidate for involvement in bipolar disorder. Recently a common functional genetic polymorphism that underlies population variation in COM Tactivity has been elucidated ...
Tópico(s): Bipolar Disorder and Treatment
1997 - Cambridge University Press | The British Journal of Psychiatry
Toru Sugiyama, Aikou Okamoto, Takayuki Enomoto, Tetsutaro Hamano, Eriko Aotani, Yasuhisa Terao, Nao Suzuki, Mikio Mikami, Nobuo Yaegashi, Kiyoko Kato, Hiroyuki Yoshikawa, Yoshihito Yokoyama, Hiroshi Tanabe, Koji Nishino, Hiroyuki Nomura, Jae‐Weon Kim, Byoung‐Gie Kim, Sandro Pignata, Jérôme Alexandre, John Green, Seiji Isonishi, Fumitoshi Terauchi, Keiichi Fujiwara, Daisuke Aoki,
Clear cell carcinoma (CCC) is a rare histologic subtype that demonstrates poor outcomes in epithelial ovarian cancer. The Japanese Gynecologic Oncology Group conducted the first randomized phase III, CCC-specific clinical trial that compared irinotecan and cisplatin (CPT-P) with paclitaxel plus carboplatin (TC) in patients with CCC.Six hundred sixty-seven patients with stage I to IV CCC of the ovary were randomly assigned to receive irinotecan 60 mg/m(2) on days 1, 8, and 15 plus cisplatin 60 mg/m( ...
Tópico(s): Testicular diseases and treatments
2016 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Produção Nacional
Revisado por pares
Francisco Sandro Menezes Rodrigues, Paolo Ruggero Errante, Regiane Miranda Ferreira, José Gustavo Padrão Tavares, Luciana de Paula, Erisvaldo Amarante de Araújo, Tânia Carmem Peñaranda Govato, Eduardo Hiroshi Tikazawa, Maria do Carmo Maia Reis, Bráulio Luna Filho, Renato Ribeiro Nogueira Ferraz, Itamar de Souza Oliveira-Júnior, Murched Omar Taha, Afonso Caricati‐Neto,
Purpose: To evaluate in vivo animal model of cardiac ischemia/reperfusion the cardioprotective activity of pancreatic lipase inhibitor of the orlistat. Methods: Adult male Wistar rats were anesthetized, placed on mechanical ventilation and underwent surgery to induce cardiac I/R by obstructing left descending coronary artery followed by reperfusion to evaluation of ventricular arrhythmias (VA), atrioventricular block (AVB) and lethality (LET) with pancreatic lipase inhibitor orlistat (ORL). At the end ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2018 - Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia | Acta Cirúrgica Brasileira
Hiroshi Azuma, Sandro Magnani,
The European Union has approved a new energy strategy for 2030, the target being to save the 27% of primary energy compared with the business-as-usual scenario and to reduce the CO2 emission of 40%. Each member state shall establish an indicator showing the energy efficiency contribution towards the Member State's 2030 target. Under such challenging target, the use of optimized energy management system has the potential to greatly contribute to the reduction of both the primary energy and the CO2 ...
Tópico(s): Advanced Thermodynamics and Statistical Mechanics
2017 - Elsevier BV | Energy Procedia
Produção Nacional
Francisco Sandro Menezes Rodrigues, Paolo Ruggero Errante, Rildo Yamaguti Lima, Alípio Carmo, Enny Fernandes Silva, Flávia de Sousa Gehrke, Diego Soares Carvalho, Eduardo Hiroshi Tikazawa, Renato Ribeiro Nogueira Ferraz, Afonso Caricati‐Neto, Murched Omar Taha,
This work aimed to discuss the gains obtained by students of higher education in the understanding and assimilation of fundamental concepts in health care courses based on the use of the problem - based learning (PBLM). A bibliographic survey was carried out in books obtained in the library of the Anhanguera University of Sao Paulo, theses, journals and scientific articles that were available in the scientific bases Scielo and Google Scholar, using as descriptor method of learning based on problems. ...
Tópico(s): Evasion and Academic Success Factors
2019 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Revista Ibero-Americana de Estudos em Educação
Arnaud Bourreille, Aleksandra Ignjatović, Lars Aabakken, Edward V. Loftus, Rami Eliakim, Marco Pennazio, Yoram Bouhnik, Ernest G. Seidman, Martin Keuchel, Jörg Albert, Sandro Ardizzone, Simon Bar–Meir, Raf Bisschops, Edward J. Despott, Paul Fortun, Robert Heuschkel, Jochen Kammermeier, Jonathan A. Leighton, Gerassimos J. Mantzaris, Driffa Moussata, Simon K. Lo, Vemund Paulsen, Julián Panés, G. Radford‐Smith, Walter Reinisch, Emanuele Rondonotti, David S. Sanders, Jason M. Swoger, Hiroshi Yamamoto, Simon Travis, J F Colombel, A. Van Gossum,
Crohn's disease and ulcerative colitis are lifelong diseases seen predominantly in the developed countries of the world.
Tópico(s): Gastrointestinal Tumor Research and Treatment
2009 - Thieme Medical Publishers (Germany) | Endoscopy
Thomas Powles, Piotr Tomczak, Se Hoon Park, Balaji Venugopal, Thomas Ferguson, Stefan N. Symeonides, Jaroslav Hájek, Howard Gurney, Yen‐Hwa Chang, Jae‐Lyun Lee, Naveed Sarwar, Antoine Thiery-Vuillemin, Marine Gross‐Goupil, Mauricio Mahave, Naomi B. Haas, Piotr Sawrycki, Joseph E. Burgents, Lei Xu, Kentaro Imai, David I. Quinn, Toni K. Choueiri, Piotr Tomczak, Toni K. Choueiri, Se Hoon Park, Balaji Venugopal, Thomas Ferguson, Jaroslav Hájek, Tzu-Ping Lin, Stefan N. Symeonides, Jae‐Lyun Lee, Piotr Sawrycki, Naomi B. Haas, Howard Gurney, Mauricio Mahave, Naveed Sarwar, Antoine Thiery-Vuillemin, Marine Gross‐Goupil, Christine Chevreau, John M. Burke, Gurjyot K. Doshi, Bohuslav Melichar, Delphine Topart, Stéphane Oudard, Evgeniy Kopyltsov, H. Hammers, David I. Quinn, Ajjai Alva, Juliana de Menezes, Adriano Goncalves e Silva, Eric Winquist, Alketa Hamzaj, Giuseppe Procopio, Boguslawa Karaszewska, Ewa M. Nowakowska-Zajdel, B. Yа. Alekseev, Rustem Gafanov, А. А. Измайлов, Andrey Semenov, S. G. Afanasyev, O. N. Lipatov, T.B. Powles, Sandy Srinivas, David F. McDermott, Samith T. Kochuparambil, Ian D. Davis, Katriina Peltola, Roberto Sabbatini, Jinsoo Chung, М. I. Shkolnik, В. Б. Матвеев, P. Gajate Borau, Steven McCune, Thomas E. Hutson, Alejandro Dri, Silvio Correia Sales, Carrie Yeung, Carmen Marcela Alcala Castro, Peter J. Boström, Brigitte Laguerre, Consuelo Buttigliero, Ugo De Giorgi, Eugeniy A. Fomin, Yousef Zakharia, Clara Hwang, Eric A. Singer, Jeffrey T. Yorio, David Waterhouse, Rubén Dario Kowalyszyn, Margarita Sonia Alfie, Eduardo Yañez Ruiz, Tomáš Büchler, Krista Kankaanranta, G. Ferretti, Go Kimura, Kazuo Nishimura, Naoya Masumori, Satoshi Tamada, Haruaki Kato, Hiroshi Kitamura, Iwona Danielewicz, Joanna Wojcik-Tomaszewska, Nuria Sala Gonzalez, Kun‐Yuan Chiu, Michael B. Atkins, Elisabeth I. Heath, Gustavo Adolfo Rojas-Uribe, Manuel Enrique Gonzalez Fernandez, Susan Feyerabend, Sandro Pignata, Kazuyuki Numakura, Bozena Cybulska Stopa, Р. А. Зуков, Miguel Á. Climent Durán, Pablo Jose Maroto Rey, Á. Montesa Pino, Chao‐Hsiang Chang, Salil Vengalil, Tom Waddell, Patrick Cobb, Ralph J. Hauke, D. Mark Anderson, John Sarantopoulos, Theodore Stewart Gourdin, Tian Zhang, Gautam Jayram, Luis Fein, Carole A. Harris, Patricia Medeiros Milhomem Beato, Francisco Flores, Angela Estay, Juan Andres Rubiano, Jens Bedke, Stefan Hauser, Andreas Neisius, Jonas Busch, Satoshi Anai, Hiroyuki Tsunemori, Dariusz Sawka, Bożena Sikora-Kupis, José Ángel Arranz, Ignacio Delgado, Chung‐Hsin Chen, Elizabeth A. Gunderson, Scott S. Tykodi, Alan J. Koletsky, Kevin Chen, Manish Agrawal, Diego Kaen, Juan Pablo Sade, Marcelo Tatangelo, Francis Parnis, Fernando Maciel Barbosa, Genevieve Faucher, Nayyer Iqbal, Danièle Marceau, Jean-Benoit Paradis, Nawar Hanna, Alejandro Acevedo, Carolina Ibáñez, Luis J. Villanueva-Rivera, Pedro Pablo Galaz, Isabel Cristina Durango, Ray Manneh Kopp, Zdeněk Král, Petra Holečková, Heikki Hakkarainen, Hanna Ronkainen, Sophie Abadie‐Lacourtoisie, Sophie Tartas, Peter J. Goebell, Marc‐Oliver Grimm, Thomas Hoefner, Manfred P. Wirth, Andrej Panic, Wolfgang Schultze-Seemann, Akira Yokomizo, Ryuichi Mizuno, Hirotsugu Uemura, Masatoshi Eto, Masao Tsujihata, Yoshihisa Matsukawa, Yoji Murakami, Miso Kim, Paul Hamberg, Malgorzata Marczewska-Skrodzka, Szczylik Cezary, Alison C. Humphreys, Peter Jiang, Birendra Kumar, Gary Lu, Arpita Desai, José A. Karam, George P. Keogh, Mark T. Fleming, Juan José Zarbá, Viviana E. Leiva, Guillermo Ariel Mendez, S.J. Harris, Stephen J. Brown, João Neif Antonio, Rita de Cassia Costamilan, Roberto Odebrecht Rocha, David Q.B. Muniz, Leandro Brust, Aly‐Khan A. Lalani, Jeffrey Graham, Michael A. Levesque, F. Orlandi, Rostislav Kotasek, Jean L. Deville, Delphine Borchiellini, Axel S. Merseburger, Michael Rink, Frederik C. Roos, Ray McDermott, Masafumi Oyama, Yoshiaki Yamamoto, Yoshihiko Tomita, Yuji Miura, Naomasa Ioritani, Hans M. Westgeest, Tomasz Kubiatowski, Wiesław Bal, Regina Gironés Sarrió, Julie Rowe, Debra M. Prow, Francis M. Senecal, Neda Hashemi‐Sadraei, Scott Cole, Stephan D. Kendall, Donald Richards, Ian D. Schnadig, Mukul Kumar Gupta,
The first interim analysis of the KEYNOTE-564 study showed improved disease-free survival with adjuvant pembrolizumab compared with placebo after surgery in patients with clear cell renal cell carcinoma at an increased risk of recurrence. The analysis reported here, with an additional 6 months of follow-up, was designed to assess longer-term efficacy and safety of pembrolizumab versus placebo, as well as additional secondary and exploratory endpoints.In the multicentre, randomised, double-blind, ...
Tópico(s): Bladder and Urothelial Cancer Treatments
2022 - Elsevier BV | The Lancet Oncology
Ekaterina Rogaeva, Yan Meng, Joseph H. Lee, Yongjun Gu, Toshitaka Kawarai, Fanggeng Zou, Taiichi Katayama, Clinton T. Baldwin, Rong Cheng, Hiroshi Hasegawa, Fusheng Chen, Nobuto Shibata, Kathryn L. Lunetta, Raphaëlle Pardossi‐Piquard, Christopher Böhm, Yosuke Wakutani, L. Adrienne Cupples, Karen T. Cuenco, Robert C. Green, Lorenzo Pinessi, Innocenzo Rainero, Sandro Sorbi, Amalia C. Bruni, Ranjan Duara, Robert P. Friedland, Rivka Inzelberg, Wolfgang Hampe, Hideaki Bujo, You‐Qiang Song, Olav M. Andersen, Thomas E. Willnow, Neill R. Graff‐Radford, Ronald Petersen, Dennis W. Dickson, Sandy D. Der, Paul E. Fraser, Gerold Schmitt‐Ulms, Steven G. Younkin, Richard Mayeux, Lindsay A. Farrer, Peter St George‐Hyslop,
The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. ...
Tópico(s): Cellular transport and secretion
2007 - Nature Portfolio | Nature Genetics
Sandro Magnani, Alessandro Bellissima, Hiroshi Azuma,
Tópico(s): Spacecraft and Cryogenic Technologies
2018 - | SAE technical papers on CD-ROM/SAE technical paper series
Sandro Magnani, Alessandro Bellissima, Hiroshi Azuma, Piero Danti,
Tópico(s): Geothermal Energy Systems and Applications
2018 - | SAE technical papers on CD-ROM/SAE technical paper series
Produção Nacional
Revisado por pares
Chrystian Aparecido Grillo Haerter, Patrik F. Viana, Fábio Hiroshi Takagui, Sandro Tonello, Vladimir Pavan Margarido, Daniel Rodrigues Blanco, Josiane Baccarin Traldi, Roberto Laridondo Lui, Eliana Feldberg,
Abstract Centromochlus heckelii has the lowest diploid chromosome number (2n = 46) and the only described heteromorphic sex chromosome system in Auchenipteridae. This study presents a population of C. heckelii from the Central Amazon basin with subtle variations in the karyotype composition and a variant W chromosome with distinct morphology and increased C-positive heterochromatin content. In this population, the W chromosome is subtelocentric, whereas the only previous study on C. heckelii reported ...
Tópico(s): CRISPR and Genetic Engineering
2025 - Brazilian Society of Genetics | Genetics and Molecular Biology
Ludmil B. Alexandrov, Jaegil Kim, Nicholas J. Haradhvala, Mi Ni Huang, Alvin Wei Tian Ng, Yang Wu, Arnoud Boot, Kyle R. Covington, Dmitry A. Gordenin, Erik N. Bergstrom, S. M. Ashiqul Islam, Núria López-Bigas, Leszek J. Klimczak, John R. McPherson, Sandro Morganella, Radhakrishnan Sabarinathan, David A. Wheeler, Ville Mustonen, Ludmil B. Alexandrov, Erik N. Bergstrom, Arnoud Boot, Paul C. Boutros, Kin Chan, Kyle R. Covington, Akihiro Fujimoto, Gad Getz, Dmitry A. Gordenin, Nicholas J. Haradhvala, Mi Ni Huang, S. M. Ashiqul Islam, Marat D. Kazanov, Jaegil Kim, Leszek J. Klimczak, Núria López-Bigas, Michael S. Lawrence, Iñigo Martincorena, John R. McPherson, Sandro Morganella, Ville Mustonen, Hidewaki Nakagawa, Alvin Wei Tian Ng, Paz Polak, Stephenie D. Prokopec, Steven A. Roberts, Steve Rozen, Radhakrishnan Sabarinathan, Natalie Saini, Tatsuhiro Shibata, Yuichi Shiraishi, Michael R. Stratton, Bin Tean Teh, Ignacio Vázquez-Garćıa, David A. Wheeler, Yang Wu, Fouad Yousif, Willie Yu, Gad Getz, Steve Rozen, Michael R. Stratton, Lauri A. Aaltonen, Federico Abascal, Adam Abeshouse, Hiroyuki Aburatani, David J. Adams, Nishant Agrawal, Keun Soo Ahn, Sung‐Min Ahn, Hiroshi Aikata, Rehan Akbani, Kadir C. Akdemir, Hikmat Al‐Ahmadie, Sultan T. Al‐Sedairy, Fátima Al‐Shahrour, Malik Alawi, Monique Albert, Kenneth Aldape, Ludmil B. Alexandrov, Adrian Ally, Kathryn Alsop, Eva G. Álvarez, Fernanda Amary, Samirkumar B. Amin, Brice Aminou, Ole Ammerpohl, Matthew J. Anderson, Yeng Ang, Davide Antonello, Pavana Anur, Samuel Aparício, Elizabeth L. Appelbaum, Yasuhito Arai, Axel Aretz, Koji Arihiro, Shun‐ichi Ariizumi, Joshua Armenia, Laurent Arnould, L. Sylvia, Yassen Assenov, Gurnit Atwal, Sietse Aukema, J. Todd Auman, Miriam R. R. Aure, Philip Awadalla, Marta Aymerich, Gary D. Bader, Adrian Baez‐Ortega, Peter J. Bailey, Peter J. Bailey, Miruna Balasundaram, Saianand Balu, Pratiti Bandopadhayay, Rosamonde E. Banks, Stefano Barbi, Andrew P. Barbour, Jonathan Barenboim, Jill S. Barnholtz‐Sloan, Hugh Barr, Elisabet Barrera, John G. Bartlett, Javier Bartolomé, Claudio Bassi, Oliver F. Bathe, Daniel Baumhoer, Prashant Bavi, Stephen B. Baylin, Wojciech Bażant, Duncan Beardsmore, Timothy A. Beck, Sam Behjati, Andreas Behren, Beifang Niu, Cindy Bell, Sergi Beltrán, Christopher C. Benz, Andrew Berchuck, Anke K. Bergmann, Erik N. Bergstrom, Benjamin P. Berman, Daniel M. Berney, Stephan Wolf, Rameen Beroukhim, Mario Berríos, Samantha Bersani, Johanna Bertl, Miguel Betancourt, Vinayak Bhandari, Shriram G. Bhosle, Andrew V. Biankin, Matthias Bieg, Darell D. Bigner, Hans Binder, Ewan Birney, Michael J. Birrer, Nidhan K. Biswas, Bodil Bjerkehagen, Tom Bodenheimer, Lori Boice, Giada Bonizzato, Johann S. de Bono, Arnoud Boot, Arnoud Boot, Åke Borg, Arndt Borkhardt, Keith A. Boroevich, Ivan Borozan, Christoph W. Borst, Marcus Bosenberg, Mattia Bosio, Jacqueline Boultwood, Guillaume Bourque, Paul C. Boutros, G. Steven Bova, David Bowen, Reanne Bowlby, David D.L. Bowtell, Sandrine Boyault, Rich Boyce, Jeffrey M. Boyd, Alvis Brāzma, Paul M. Brennan, Daniel Brewer, Arie B. Brinkman, Robert G. Bristow, Russell R. Broaddus, Jane E. Brock, Malcolm V. Brock, Annegien Broeks, Angela N. Brooks, Denise Brooks, Benedikt Brors, Søren Brunak, Timothy J. C. Bruxner, Alicia L. Bruzos, Alex Buchanan, Ivo Buchhalter, Christiane Buchholz, Susan Bullman, Hazel Burke, Birgit Burkhardt, Kathleen H. Burns, John Busanovich, Carlos D. Bustamante, Adam P. Butler, Atul J. Butte, Niall J. Byrne, Anne‐Lise Børresen‐Dale, Rory Johnson, Andy Cafferkey, Declan Cahill, Claudia Calabrese, Carlos Caldas, Fabien Calvo, Niedzica Camacho, Peter J. Campbell, Elı́as Campo, Cinzia Cantù, Shaolong Cao, Thomas E. Carey, Joana Carlevaro-Fita, Rebecca Carlsen, Ivana Cataldo, Mario Cazzola, Jonathan Cebon, Robert J. Cerfolio, Dianne Chadwick, Dimple Chakravarty, Drc Chalmers, Calvin Wing Yiu Chan, Kin Chan, Michelle Chan‐Seng‐Yue, Vishal S. Chandan, David K. Chang, Stephen J. Chanock, Keiran Raine, Aurélien Chateigner, Nilanjan Chatterjee, Kazuaki Chayama, Hsiao-Wei Chen, Jieming Chen, Ken Chen, Yiwen Chen, Zhaohong Chen, Andrew D. Cherniack, Jeremy Chien, Yoke-Eng Chiew, Suet‐Feung Chin, Juok Cho, Sunghoon Cho, Jung Kyoon Choi, Wan Choi, Christine Chomienne, Zechen Chong, Su Pin Choo, Angela Chou, Angelika N. Christ, Elizabeth L. Christie, Eric Chuah, Carrie Cibulskis, Kristian Cibulskis, Sara Cingarlini, Peter Clapham, Alexander Claviez, Sean P. Cleary, Nicole Cloonan, Marek Cmero, Colin C. Collins, Ashton A. Connor, Susanna L. Cooke, Colin S. Cooper, Leslie Cope, Vincenzo Corbo, Matthew G. Cordes, Stephen Cordner, Isidro Cortés‐Ciriano, Kyle R. Covington, Prue A. Cowin, Brian Craft, David Craft, Chad J. Creighton, Yupeng Cun, Erin Curley, Ioana Cutcutache, Karolina Czajka, Bogdan Czerniak, Rebecca A. Dagg, Ludmila Danilova, Maria Vittoria Davì, Natalie R. Davidson, Helen Davies, Ian J. Davis, Brandi N. Davis‐Dusenbery, Kevin J. Dawson, Francisco M. De La Vega, Ricardo De Paoli‐Iseppi, Timothy Defreitas, Angelo Paolo Dei Tos,
Abstract Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature 1 . Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium 2 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we characterized mutational signatures using 84,729,690 somatic mutations from 4,645 whole-genome and 19,184 exome sequences that encompass most types of cancer. We identified 49 single- ...
Nature Portfolio
Mari Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Gita A. Pathak, Shea J. Andrews, Masahiro Kanai, Kumar Veerapen, Israel Fernández‐Cadenas, Eva C. Schulte, Pasquale Striano, M. Marttila, Camelia C. Minică, Eirini Marouli, Mohd Anisul Karim, Frank R. Wendt, Jeanne E. Savage, Laura Sloofman, Guillaume Butler‐Laporte, Han‐Na Kim, Stavroula Kanoni, Yukinori Okada, Jinyoung Byun, Younghun Han, Mohammed Jashim Uddin, George Davey Smith, Cristen J. Willer, Joseph D. Buxbaum, Juha Mehtonen, Hilary K. Finucane, Mattia Cordioli, Alicia R. Martin, Wei Zhou, Bogdan Paşaniuc, Hanna Julienne, Hugues Aschard, Huwenbo Shi, Loïc Yengo, Renato Polimanti, Maya Ghoussaini, Jeremy Schwartzentruber, Ian Dunham, Karolina Chwiałkowska, Margherita Francescatto, Amy Trankiem, Mary K. Balaconis, Lea K. Davis, Sulggi A. Lee, James R. Priest, Alessandra Renieri, Vijay G. Sankaran, David A. van Heel, Patrick Deelen, J. Brent Richards, Tomoko Nakanishi, Les Biesecker, V. Eric Kerchberger, J. Kenneth Baillie, Francesca Mari, Anna Bernasconi, J. Kenneth Baillie, Arif Canakoglu, Brooke N. Wolford, Annika Faucon, Atanu Kumar Dutta, Claudia Schurmann, Emi N. Harry, Ewan Birney, Huy Nguyen, Jamal Nasir, Mari Kaunisto, Matthew Solomonson, Nicole Dueker, Nirmal Vadgama, Sophie Limou, Souad Rahmouni, Hamdi Mbarek, Dima Darwish, Md Mesbah Uddin, Raquel Albertos, Jordi Pérez‐Tur, Ruolin Li, Lasse Folkersen, Ida Moltke, Nils Koelling, Alexander Teumer, Athanasios Kousathanas, Alicia Utrilla, Ricardo A. Verdugo, Ruth Zárate, Carolina Medina‐Gómez, David Gómez-Cabrero, Elena Carnero‐Montoro, Carmen L. Cadilla, Andrés Moreno‐Estrada, Adriana Garmendia, Leire Moya, Bahareh Sedaghati-khayat, Palwendé Romuald Boua, Marie-Julie Favé, Laurent C. Francioli, Audrey Lemaçon, Isabelle Migeotte, Sanjay Patel, Réka Várnai, József Szentpéteri, Csilla Sipeky, Francesca Colombo, Kathrin von Hohenstaufen, Píetro Lió, Costanza L. Vallerga, Qingbo Wang, Yosuke Tanigawa, Hogune Im, Chulho Han, Han Song, Jiwoo Lim, Y.‐A. Lee, Sugyeong Kim, Sangyoon Im, Biljana Atanasovska, Hajar Fauzan Ahmad, Cindy G. Boer, Philip R. Jansen, Lude Franke, Elżbieta Kaja, Dorota Pasko, Ingrid Kennis-Szilagyi, Sergey A. Kornilov, Vid Prijatelj, Ivana Nedeljković, Ilangkumaran Sivanadhan, Sarala Perumal, Sahar Esmaeeli, Nathaniel M. Pearson, Adam Auton, Janie F. Shelton, Anjali J. Shastri, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Jorge Esparza-Gordillo, Stella Aslibekyan, Jared O’Connell, Chelsea Ye, Catherine H. Weldon, Minoli A. Perera, Kevin J. O’Leary, Matthew Tuck, Travis J. O’Brien, David Meltzer, Peter H. O’Donnell, Edith A. Nutescu, Guang Yang, Cristina Alarcón, Stefanie Herrmann, Sophia Mazurek, Jeff Banagan, Zacharia Hamidi, April Barbour, Noora Raffat, Diana Moreno, Paula N. Friedman, Bart Ferwerda, Diederik van de Beek, Matthijs C. Brouwer, Alexander P. J. Vlaar, W. Joost Wiersinga, Daniëlle Posthuma, Elleke Tissink, A. H. Koos Zwinderman, Emil Uffelmann, Michiel A. van Agtmael, Anne Geke Algera, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije K. Bomers, Peter I. Bonta, Lieuwe D. J. Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, Sanne de Bruin, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Dave A. Dongelmans, Paul Elbers, Lucas M. Fleuren, Suzanne E. Geerlings, Bart F. Geerts, Teunis B. H. Geijtenbeek, Armand R. J. Girbes, Abraham Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura A. Hagens, Jörg Hamann, Vanessa Harris, Robert Hemke, Sabine Hermans, Leo Heunks, Markus W. Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Niels van Mourik, Jeannine F. Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom D. Y. Reijnders, Michiel Schinkel, Marcus J. Schultz, Alex R. Schuurman, Kim Sigaloff, Marry R. Smit, Cornelis Stijnis, Willemke Stilma, Charlotte E. Teunissen, Patrick Thoral, Anissa M. Tsonas, Marc van der Valk, Denise P. Veelo, Heder de Vries, Michèle van Vugt, Dorien Wouters, René Minnaar, Adrie Kromhout, Kees W. J. van Uffelen, Ruud A. Wolterman, Genevieve Roberts, Daniel J. Park, Catherine A. Ball, Marie V. Coignet, Shannon McCurdy, Spencer C. Knight, Raghavendran Partha, Brooke Rhead, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Miloš Pavlović, Eurie L. Hong, Kristin A. Rand, Ahna R. Girshick, Harendra Guturu, Asher Haug Baltzell, Souad Rahmouni, Julien Guntz, Y Beguin, Sara Pigazzini, Lindokuhle Nkambule, Youssef Bouysran, Adeline Busson, Xavier Peyrassol, Françoise Wilkin, Bruno Pichon, Guillaume Smits, Isabelle Vandernoot, Jean‐Christophe Goffard, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Julien Guiot, Laurent Jadot, Samira Azarzar, Patricia Dellot, Stéphanie Gofflot, Sabine Claassen, Axelle Bertrand, Gilles Parzibut, Mathilde Clarinval, Catherine Moermans, Olivier Malaise, Kamilia El Kandoussi, Raphaël Thonon, Pascale Huynen, Alyssia Mesdagh, Sofia Ferreira Melo, Nicolas Jacques, Emmanuel Di Valentin, François Giroule,
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed ...
Nature Portfolio
Rajiv Agarwal, Wanzhu Tu, Alfredo E. Farjat, Youssef M.K. Farag, Robert D. Toto, Sanjay Kaul, Robert Lawatscheck, Katja Rohwedder, Luís M. Ruilope, Peter Rossing, Bertram Pitt, Gerasimos Filippatos, Stefan D. Anker, George L. Bakris, Augusto Vallejos, Richard J. MacIsaac, Guntram Schernthaner, Pieter Gillard, Maria Eugênia Fernandes Canziani, Theodora Temelkova‐Kurktschiev, Ellen Burgess, Sheldon W. Tobe, Fernando González, Zhihong Liu, Andrés Ángelo Cadena Bonfanti, Carlos Jaramillo, Martin Prázný, Jorma Strand, Michel Marre, Roland E. Schmieder, Christoph Wanner, Pantelis Sarafidis, Juliana C.N. Chan, László Rosivall, Joseph A. Eustace, Ehud Grossman, Yoram Yagil, Giuseppe Remuzzi, Daisuke Koya, Takashi Wada, Magdalena Madero Rovalo, Ron T. Gansevoort, Adriaan Kooy, Trine Finnes, Froilan DeLeon, Janusz Gumprecht, Fernando Teixeira e Costa, Alexander Dreval, Anantharaman Vathsala, Aslam Amod, Sin Gon Kim, Byung‐Wan Lee, Julio Pascual Santos, Bengt-Olov Tengmark, Michel Burnier, Chien‐Te Lee, Sukit Yamwong, Ramazan Sarı, Kieran McCafferty, Borys Mankovsky, Sharon G. Adler, Linda F. Fried, Mark V. Williams, Tran Quang Khanh, Diego Aizenberg, Inés Bartolacci, Diego Besada, Julio Bittar, Mariano Chahin, Alicia Elbert, Elizabeth Gelersztein, Alberto Liberman, Laura Maffei, Federico Pérez Manghi, Hugo Sanabria, Gloria Viñes, Alfredo Wassermann, Walter P. Abhayaratna, Shamasunder Acharya, Elif I. Ekinci, Darren Lee, Peak Mann Mah, Craig Nelson, David Packham, Alexia Pape, Simon D. Roger, Hugo Stephenson, Michael Suranyi, Gary Wittert, Elizabeth Vale, Martin Clodi, Christoph Ebenbichler, Evelyn Fließer-Görzer, Ursula Hanusch, Michael Krebs, Karl Lhotta, Bernhard Ludvik, Gert Mayer, Peter Neudorfer, Bernhard Paulweber, Rudolf Prager, Wolfgang Preiß, Friedrich C. Prischl, G. Schernthaner, Harald Sourij, Martin Wiesholzer, Peter Doubel, W. Engelen, Pieter Gillard, Jean‐Michel Hougardy, Jean-Marie Krzesinski, Bart Maes, Marijn M. Speeckaert, Koen Stas, Luc Van Gaal, Hilde Vanbelleghem, Daniela Antunes, Roberto Botelho, Cláudia Brito, Luís Henrique Santos Canani, Maria Eugênia Fernandes Canziani, Maria Cerqueira, Rogério de Paula, Freddy G. Eliaschewitz, Carlos Eduardo Poli‐de‐Figueiredo, Adriana Costa e Forti, Miguel Nasser Hissa, Maurilo Leite, Emerson de Lima, Irene L. Noronha, Bruno Paolino, Nathalia Paschoalin, Raphael Paschoalin, Roberto Pécoits-Filho, Marcio Pereira, Evandro Portes, Dalton Bertolim Précoma, Rosângela Réa, Miguel C. Riella, João Eduardo Nunes Salles, Eduardo Vasconcellos, Sérgio Vencio, Paul E. Barré, Brian Carlson, James Conway, Serge Cournoyer, R Dumas, Sameh Fikry, Richard Goluch, Pavel Hamet, Randolph Hart, Sam Henein, Joanne Liutkus, François Madore, Valdemar Martinho, Giuseppe Mazza, Philip A. McFarlane, Dennis O’ Keefe, Sean D. Peterson, Daniel Schwartz, Daniel Shu, Andrew Steele, Guy Tellier, Karthik Tennankore, Sheldon W. Tobe, George Tsoukas, Richard Tytus, Louise Vitou, Michael Walsh, S. John Weisnagel, Igor Wilderman, Jean‐François Yale, Jorge Cobos, Juan Godoy, Fernando González, Sergio Lobos, Juan Carlos Palma, Juan Carlos Prieto, Eliana Reyes, Carmen Romero, Víctor Saavedra, Mario Vega, Ruifang Bu, Cai H, Nan Chen, Qinkai Chen, Dejun Chen, Jinluo Cheng, Youping Dong, Junwu Dong, Tianjun Guan, Chuan‐Ming Hao, Wen Huang, Fangfang Jiang, Minxiang Lei, Ling Li, Zhonghe Li, Xuemei Li, Jingmei Li, Yan Li, Xinling Liang, Bo Liang, Fang Liu, Yinghong Liu, Yuan-Tao Liu, Zhihong Liu, Gang Long, Guoyuan Lu, Weiping Lu, Yibing Lu, Ping Luo, Jianhua Ma, Zhaohui Mo, Jianying Niu, Ai Peng, Jiansong Shen, Feixia Shen, Bingyin Shi, Qing Su, Zhuxing Sun, Shuifu Tang, Nanwei Tong, Hao Wang, Xinjun Wang, Lihua Wang, Guixia Wang, Jianqin Wang, Yangang Wang, Li Wang, Jiali Wei, Tianfeng Wu, Chao-Qing Wu, Xing Changying, Fei Xiong, Xudong Xu, Ning Xu, Tiekun Yan, Jinkui Yang, Aiping Yin, Longyi Zeng, Hao Zhang, Yanlin Zhang, Ying Zhang, Wenjing Zhao, Zhiquan Zhao, Hongguang Zheng, Ling Zhong, Dalong Zhu, Yongze Zhuang, Clara Arango, Sandra Barrera, Nelly Beltrán López, Diego Benitez, Guillermo Blanco, Andrés Cadena, Julián Coronel, Carlos Cure, Carlos Durán, Alexander Ariel Padrón González, Gustavo Guzmán, Eric Hernández, Jaime Ibarra, Carlos Jaramillo, Nicolás Jaramillo, William Kattah, Dora I. Molina, Gregorio Sánchez, Mónica Terront, Freddy Trujillo, Miguel Urina‐Triana, Ruben Vargas, Iván Villegas, Hernán Yupanqui, D Alferi, Michal Brada, Jiri Brezina, Petr Bucek, Tomáš Edelsberger, Drahomira Gulakova, J Zapletalová, Olga Hola, Lucie Hornova, Jana Houdova, Helena Hrmova, David Karásek, Sarka Kopecka, Richard Kovar, Eva Krčová, Jiří Kuchař, Vlasta Kutejova, H Lubanda, Ivo Matyasek, Magdaléna Mokrejšová, Libor Okenka, Martin Prázný, Jiri Pumprla,
In patients with chronic kidney disease (CKD) and type 2 diabetes (T2D), finerenone, a nonsteroidal mineralocorticoid receptor antagonist, reduces cardiovascular and kidney failure outcomes. Finerenone also lowers the urine albumin-to-creatinine ratio (UACR). Whether finerenone-induced change in UACR mediates cardiovascular and kidney failure outcomes is unknown.
American College of Physicians
Daniel J. Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md. Joynal Abedin, Hagai Abeliovich, Abraham Acevedo‐Arozena, Hiroaki Adachi, Christopher M. Adams, Peter D. Adams, Khosrow Adeli, Peter J. Adhihetty, Sharon G. Adler, Galila Agam, Rajesh Agarwal, Manish K. Aghi, Maria Agnello, Patrizia Agostinis, Patricia V. Aguilar, Julio A. Aguirre‐Ghiso, Edoardo M Airoldi, Slimane Ait‐Si‐Ali, Takahiko Akematsu, Emmanuel T. Akporiaye, Mohamed Al‐Rubeai, Guillermo M. Albaiceta, Chris Albanese, Diego Albani, Matthew L. Albert, Jesús Aldudo, Hana Algül, Mehrdad Alirezaei, Iraide Alloza, Alexandru Almasan, Maylin Almonte-Beceril, Emad S. Alnemri, Covadonga Alonso, Nihal Altan‐Bonnet, Dario C. Altieri, Silvia Álvarez, Lydia Álvarez-Erviti, Sandro Alves, Giuseppina Amadoro, Atsuo Amano, Consuelo Amantini, Santiago Ambrosio, Ivano Amelio, Amal O. Amer, Mohamed Amessou, Angelika Amon, Zhenyi An, Frank A. Anania, Stig Uggerhøj Andersen, Usha P. Andley, Catherine Andreadi, Nathalie Andrieu‐Abadie, Alberto Anel, David K. Ann, Shailendra Anoopkumar‐Dukie, Manuela Antonioli, Hiroshi Aoki, Nadezda Apostolova, Saveria Aquila, Katia Aquilano, Koichi Araki, Eli Arama, Agustı́n Aranda, Jun Araya, Alexandre Arcaro, Esperanza Arias, Hirokazu Arimoto, Aileen Ariosa, Jane L. Armstrong, Thierry Arnould, Ivica Arsov, Katsuhiko Asanuma, Valerie Askanas, Éric Asselin, Ryuichiro Atarashi, Sally S. Atherton, Julie D. Atkin, Laura D. Attardi, Patrick Auberger, Georg Auburger, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Maria Laura Avantaggiati, Limor Avrahami, Suresh Awale, Neelam Azad, Tiziana Bachetti, Jonathan Backer, Dong-Hun Bae, Jae‐sung Bae, Ok‐Nam Bae, Soo Han Bae, Eric H. Baehrecke, Seung‐Hoon Baek, Stephen Baghdiguian, Agnieszka Bagniewska‐Zadworna, Hua Bai, Jie Bai, Xueyuan Bai, Yannick Bailly, Kithiganahalli Narayanaswamy Balaji, Walter Balduini, Andrea Ballabio, Rena Balzan, Rintu Banerjee, Gábor Bánhegyi, Haijun Bao, Benoı̂t Barbeau, M D Barrachina, Esther Barreiro, Bonnie Bartel, Alberto Bartolomé, Diane C. Bassham, Maria Teresa Bassi, Robert C. Bast, Alakananda Basu, Maria Teresa Batista, Henri Batoko, Maurizio Battino, Kyle A. Bauckman, Bradley L. Baumgarner, K. Ulrich Bayer, Rupert Beale, Jean‐François Beaulieu, George R. Beck, Christoph Becker, J. David Beckham, Pierre‐André Bédard, Patrick J. Bednarski, Thomas J. Begley, Christian Behl, Christian Behrends, Georg M. N. Behrens, K.E. Behrns, Eloy Bejarano, Amine Belaïd, Francesca Belleudi, Giovanni Bénard, Guy Berchem, Daniele Bergamaschi, Matteo Bergami, Ben Berkhout, Laura Berliocchi, Amélie Bernard, Monique Bernard, Francesca Bernassola, Anne Bertolotti, Amanda S. Bess, Sébastien Besteiro, Saverio Bettuzzi, Savita Bhalla, Shalmoli Bhattacharyya, Sujit K. Bhutia, Caroline Biagosch, Michele Wolfe Bianchi, Martine Biard-Piechaczyk, Viktor Billes, Cláudia Bincoletto, Baris Bingol, Sara W. Bird, Marc Bitoun, Ivana Bjedov, Craig Blackstone, Lionel Blanc, Guillermo Blanco, Heidi Kiil Blomhoff, Emilio Boada-Romero, Stefan Böckler, Marianne Boes, Kathleen Boesze‐Battaglia, Lawrence Boise, Alessandra Bolino, Andrea Boman, Paolo Bonaldo, Matteo Bordi, Jürgen Bosch, Luís M. Botana, Joëlle Botti, Germán Bou, Marina Bouché, Marion Bouchecareilh, Marie‐Josée Boucher, Michael E. Boulton, Sébastien G. Bouret, Patricia Boya, Michaël Boyer‐Guittaut, Peter V. Bozhkov, Nathan Brady, Vania Braga, Claudio Brancolini, Gerhard H. Braus, José Manuel Bravo‐San Pedro, Lisa Brennan, Emery Bresnick, Patrick Brest, Dave Bridges, Marie-Agnès Bringer, Marisa Brini, Glauber C. Brito, Bertha Brodin, Paul S. Brookes, Karen Brown, Karen Brown, Hal E. Broxmeyer, Alain Bruhat, Patrı́cia C. Brum, John H. Brumell, Nicola Brunetti‐Pierri, Robert J. Bryson‐Richardson, Shilpa Buch, Alastair M. Buchan, Hikmet Budak, Dmitry V. Bulavin, Scott J. Bultman, Geert Bultynck, Vladimir Bumbaširević, Yan Burelle, Robert E. Burke, Margit Burmeister, Peter Bütikofer, Laura Caberlotto, Ken Cadwell, Monika Cahová, Jingjing Cai, Jingjing Cai, Qian Cai, Sara Calatayud, Nadine Camougrand, Michelangelo Campanella, Grant R. Campbell, Matthew Campbell, Silvia Campello, Robin Candau, Isabella Caniggia, L Cantoni, Lizhi Cao, Allan Caplan, Michele Caraglia, Claudio Cardinali, Sandra M. Cardoso, Jennifer S. Carew, Laura A. Carleton, Cathleen R. Carlin, Silvia Carloni, Sven R. Carlsson, Didac Carmona‐Gutiérrez, Letícia A. M. Carneiro, Oliana Carnevali, Serena Carra, Alice Carrier, Bernadette Carroll, Caty Casas, Josefina Casas, Giuliana Cassinelli, Perrine Castets, Susana Castro‐Obregón, Gabriella Cavallini, Isabella Ceccherini, Francesco Cecconi, Arthur I. Cederbaum, Valentı́n Ceña, Simone Cenci, Claudia Cerella, Davide Cervia, Silvia Cetrullo, Hassan Chaachouay, Han‐Jung Chae, Andrei S. Chagin, Chee‐Yin Chai, Gopal Chakrabarti, Georgios Chamilos, Matthew T.V. Chan, Matthew T.V. Chan, Dhyan Chandra, Pallavi Chandra, Chih‐Peng Chang, Raymond Chuen‐Chung Chang, Ta‐Yuan Chang, John C. Chatham, Saurabh Chatterjee, Santosh Chauhan, Yongsheng Che, Michael E. Cheetham, Rajkumar Cheluvappa, Chun‐Jung Chen, Guang‐Chao Chen, Guang‐Chao Chen, Guoqiang Chen, Hongzhuan Chen, Jeff W. Chen, Jian‐Kang Chen, Min Chen,
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues ...
Taylor & Francis
Daniel J. Klionsky, Kotb Abdelmohsen, Akihisa Abe, Joynal Abedin, Hagai Abeliovich, Abraham Acevedo‐Arozena, Hiroaki Adachi, Christopher M. Adams, Peter D. Adams, Khosrow Adeli, Peter J. Adhihetty, Sharon G. Adler, Galila Agam, Rajesh Agarwal, Manish K. Aghi, Maria Agnello, Patrizia Agostinis, Patricia V. Aguilar, Julio A. Aguirre‐Ghiso, Edoardo M. Airoldi, Slimane Ait‐Si‐Ali, Takahiko Akematsu, Emmanuel T. Akporiaye, Mohamed Al‐Rubeai, Guillermo M. Albaiceta, Chris Albanese, Diego Albani, Matthew L. Albert, Jesús Aldudo, Hana Algül, Mehrdad Alirezaei, Iraide Alloza, Alexandru Almasan, Maylin Almonte-Beceril, Emad S. Alnemri, Covadonga Alonso, Nihal Altan‐Bonnet, Dario C. Altieri, Silvia Álvarez, Lydia Álvarez-Erviti, Sandro Alves, Giuseppina Amadoro, Atsuo Amano, Consuelo Amantini, Santiago Ambrosio, Ivano Amelio, Amal O. Amer, Mohamed Amessou, Angelika Amon, Zhenyi An, Frank A. Anania, Stig Uggerhøj Andersen, Usha P. Andley, Catherine Andreadi, Nathalie Andrieu‐Abadie, Alberto Anel, David K. Ann, Shailendra Anoopkumar‐Dukie, Manuela Antonioli, Hiroshi Aoki, Nadezda Apostolova, Saveria Aquila, Katia Aquilano, Koichi Araki, Eli Arama, Agustı́n Aranda, Jun Araya, Alexandre Arcaro, Esperanza Arias, Hirokazu Arimoto, Aileen Ariosa, Jane L. Armstrong, Thierry Arnould, Ivica Arsov, Katsuhiko Asanuma, Valerie Askanas, Éric Asselin, Ryuichiro Atarashi, Sally S. Atherton, Julie D. Atkin, Laura D. Attardi, Patrick Auberger, Georg Auburger, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Maria Laura Avantaggiati, Limor Avrahami, Neelam Azad, Suresh Awale, Tiziana Bachetti, Jonathan Backer, Dong-Hun Bae, Jae‐sung Bae, Ok‐Nam Bae, Soo Han Bae, Eric H. Baehrecke, Seung‐Hoon Baek, Stephen Baghdiguian, Agnieszka Bagniewska‐Zadworna, Hua Bai, Jie Bai, Xueyuan Bai, Yannick Bailly, Kithiganahalli Narayanaswamy Balaji, Walter Balduini, Andrea Ballabio, Rena Balzan, Rintu Banerjee, Gábor Bánhegyi, Haijun Bao, Benoı̂t Barbeau, M D Barrachina, Esther Barreiro, Bonnie Bartel, Alberto Bartolomé, Diane C. Bassham, Maria Teresa Bassi, Robert C. Bast, Alakananda Basu, Maria Teresa Batista, Henri Batoko, Maurizio Battino, Kyle A. Bauckman, Bradley L. Baumgarner, K. Ulrich Bayer, Rupert Beale, Jean‐François Beaulieu, George R. Beck, Christoph Becker, J. David Beckham, Pierre‐André Bédard, Patrick J. Bednarski, Thomas J. Begley, Christian Behl, Christian Behrends, Georg M. N. Behrens, K.E. Behrns, Eloy Bejarano, Amine Belaïd, Francesca Belleudi, Giovanni Bénard, Guy Berchem, Daniele Bergamaschi, Matteo Bergami, Ben Berkhout, Laura Berliocchi, Amélie Bernard, Monique Bernard, Francesca Bernassola, Anne Bertolotti, Amanda S. Bess, Sébastien Besteiro, Saverio Bettuzzi, Savita Bhalla, Shalmoli Bhattacharyya, Sujit K. Bhutia, Caroline Biagosch, Michele Wolfe Bianchi, Martine Biard-Piechaczyk, Viktor Billes, Cláudia Bincoletto, Baris Bingol, Sara W. Bird, Marc Bitoun, Ivana Bjedov, Craig Blackstone, Lionel Blanc, Guillermo Blanco, Heidi Kiil Blomhoff, Emilio Boada-Romero, Stefan Böckler, Marianne Boes, Kathleen Boesze‐Battaglia, Lawrence Boise, Alessandra Bolino, Andrea Boman, Paolo Bonaldo, Matteo Bordi, Jürgen Bosch, Luís M. Botana, Joëlle Botti, Germán Bou, Marina Bouché, Marion Bouchecareilh, Marie‐Josée Boucher, Michael E. Boulton, Sébastien G. Bouret, Patricia Boya, Michaël Boyer‐Guittaut, Peter V. Bozhkov, Nathan Brady, Vania Braga, Claudio Brancolini, Gerhard H. Braus, José M. Bravosan-Pedro, Lisa Brennan, Emery Bresnick, Patrick Brest, Dave Bridges, Marie-Agnès Bringer, Marisa Brini, Glauber C. Brito, Bertha Brodin, Paul S. Brookes, Karen Brown, Karen Brown, Hal E. Broxmeyer, Alain Bruhat, Patrı́cia C. Brum, John H. Brumell, Nicola Brunetti‐Pierri, Robert J. Bryson‐Richardson, Shilpa Buch, Alastair M. Buchan, Hikmet Budak, Dmitry V. Bulavin, Scott J. Bultman, Geert Bultynck, Vladimir Bumbaširević, Yan Burelle, Robert E. Burke, Margit Burmeister, Peter Bütikofer, Laura Caberlotto, Ken Cadwell, Monika Cahová, Jingjing Cai, Jingjing Cai, Qian Cai, Sara Calatayud, Nadine Camougrand, Michelangelo Campanella, Grant R. Campbell, Matthew P. Campbell, Silvia Campello, Robin Candau, Isabella Caniggia, L Cantoni, Lizhi Cao, Allan Caplan, Michele Caraglia, Claudio Cardinali, Sandra M. Cardoso, Jennifer S. Carew, Laura A. Carleton, Cathleen R. Carlin, Silvia Carloni, Sven R. Carlsson, Didac Carmona‐Gutiérrez, Letícia A. M. Carneiro, Oliana Carnevali, Serena Carra, Alice Carrier, Bernadette Carroll, Caty Casas, Josefina Casas, Giuliana Cassinelli, Perrine Castets, Susana Castro‐Obregón, Gabriella Cavallini, Isabella Ceccherini, Francesco Cecconi, Arthur I. Cederbaum, Valentı́n Ceña, Simone Cenci, Claudia Cerella, Davide Cervia, Silvia Cetrullo, Hassan Chaachouay, Han‐Jung Chae, Andrei S. Chagin, Chee‐Yin Chai, Gopal Chakrabarti, Georgios Chamilos, Edmond Y.W. Chan, Matthew T.V. Chan, Dhyan Chandra, Pallavi Chandra, Chih‐Peng Chang, Raymond Chuen‐Chung Chang, Ta‐Yuan Chang, John C. Chatham, Saurabh Chatterjee, Santosh Chauhan, Yongsheng Che, Michael E. Cheetham, Rajkumar Cheluvappa, Chun‐Jung Chen, Guang‐Chao Chen, Guang‐Chao Chen, Guoqiang Chen, Hongzhuan Chen, Jeff W. Chen, Jian‐Kang Chen, Min Chen,
BioMed Central
Daniel J. Klionsky, Amal Kamal Abdel‐Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, Abraham Acevedo‐Arozena, Iannis E. Adamopoulos, Khosrow Adeli, Timon E. Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B. Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N. Agrewala, Alexander Agrotis, Patricia V. Aguilar, S. Tariq Ahmad, Zubair M. Ahmed, Ulises Ahumada-Castro, Sonja Aits, Shu Aizawa, Yunus Akkoç, Tonia Akoumianaki, Hafize Aysin Akpinar, Ahmed M. Al‐Abd, Lina Al-Akra, Abeer Gharaibeh, Moulay A. Alaoui‐Jamali, Simon Alberti, Elísabet Alcocer‐Gómez, Cristiano Alessandri, Muhammad Ali, Md. Abdul Alim Al‐Bari, Saeb Aliwaini, Javad Alizadeh, Eugènia Almacellas, Alexandru Almasan, Alicia Alonso, G. Alonso, Nihal Altan‐Bonnet, Dario C. Altieri, Élida Álvarez, Sara Alves, Cristine Alvès da Costa, Mazen M. Alzaharna, Marialaura Amadio, Consuelo Amantini, Cristina Amaral, Susanna Ambrosio, Amal O. Amer, Veena Ammanathan, Zhenyi An, Stig Uggerhøj Andersen, Shaida A. Andrabi, Magaiver Andrade-Silva, Allen M. Andres, Sabrina Angelini, David K. Ann, Uche C. Anozie, Mohammad Y. Ansari, Pedro Antas, Adam Antebi, Zuriñe Antón, Tahira Anwar, Lionel Apétoh, Nadezda Apostolova, Toshiyuki Araki, Yasuhiro Araki, Kohei Arasaki, Wagner L. Araújo, Jun Araya, Catherine Arden, María‐Ángeles Arévalo, Sandro Argüelles, Esperanza Arias, Jyothi Arikkath, Hirokazu Arimoto, Aileen Ariosa, Darius Armstrong‐James, Laetitia Pelloquin, Ángeles Aroca, Daniela S. Arroyo, Ivica Arsov, Rubén Artero, Dalia Maria Lucia Asaro, Michael Aschner, Milad Ashrafizadeh, Osnat Ashur‐Fabian, Atanas G. Atanasov, Alicia K. Au, Patrick Auberger, Holger W. Auner, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Yenniffer Ávalos, Sanja Aveic, Célia A. Aveleira, Tamar Avin‐Wittenberg, Yücel Aydın, Scott Ayton, Srinivas Ayyadevara, Maria Azzopardi, Misuzu Baba, Jonathan Backer, Steven K. Backues, Dong-Hun Bae, Ok‐Nam Bae, Soo Han Bae, Eric H. Baehrecke, Ahruem Baek, Seung‐Hoon Baek, Sung Hee Baek, Giacinto Bagetta, Agnieszka Bagniewska‐Zadworna, Hua Bai, Jie Bai, Xiyuan Bai, Yidong Bai, Nandadulal Bairagi, Shounak Baksi, Teresa Balbi, Cosima T. Baldari, Walter Balduini, Andrea Ballabio, María Ballester, Salma Balazadeh, Rena Balzan, Rina Bandopadhyay, Sreeparna Banerjee, Sulagna Banerjee, Ágnes Bánréti, Yan Bao, Maurı́cio S. Baptista, Alessandra Baracca, Cristiana Barbati, Ariadna Bargiela, Daniela Barilà, Peter G. Barlow, Sami J. Barmada, Esther Barreiro, George E. Barreto, Jiří Bártek, Bonnie Bartel, Alberto Bartolomé, Gaurav Barve, Suresh H. Basagoudanavar, Diane C. Bassham, Robert C. Bast, Alakananda Basu, Henri Batoko, Isabella Batten, E.E. Baulieu, Bradley L. Baumgarner, Jagadeesh Bayry, Rupert Beale, Isabelle Beau, Florian Beaumatin, Luiz Roberto Grassmann Bechara, George R. Beck, Michael F. Beers, Jakob Begun, Christian Behrends, Georg M. N. Behrens, Roberto Bei, Eloy Bejarano, Shai Bel, Christian Behl, Amine Belaïd, Naïma Belgareh‐Touzé, Cristina Bellarosa, Francesca Belleudi, Melissa Belló-Pérez, Raquel Bello-Morales, Jackeline Soares de Oliveira Beltran, Sebastián Beltran, Doris M. Benbrook, Mykolas Bendorius, Bruno A. Benítez, Irene Benito‐Cuesta, Julien Bensalem, Martin W. Berchtold, Sabina Berezowska, Daniele Bergamaschi, Matteo Bergami, Andreas Bergmann, Laura Berliocchi, Clarisse Berlioz‐Torrent, Amélie Bernard, Lionel Berthoux, Cagri G. Besirli, Sébastien Besteiro, Virginie M.S. Betin, Rudi Beyaert, Jelena S. Bezbradica, Kiran Bhaskar, Ingrid Bhatia‐Kiššová, Resham Bhattacharya, Sujoy Bhattacharya, Shalmoli Bhattacharyya, Md. Shenuarin Bhuiyan, Sujit K. Bhutia, Lanrong Bi, Xiaolin Bi, Trevor J. Biden, Krikor Bijian, Viktor Billes, Nadine Binart, Cláudia Bincoletto, Åsa Birna Birgisdottir, Geir Bjørkøy, Gonzalo Blanco, Ana Blas‐García, Janusz Błasiak, Robert Blomgran, Klas Blomgren, Janice S. Blum, Emilio Boada-Romero, Mirta Boban, Kathleen Boesze‐Battaglia, Philippe Boeuf, Barry Boland, Pascale Bomont, Paolo Bonaldo, Srinivasa Reddy Bonam, Laura Bonfili, Juan S. Bonifacino, Brian A. Boone, Martin D. Bootman, Matteo Bordi, Christoph Borner, Beat Bornhäuser, Gautam Borthakur, Jürgen Bosch, Santanu Bose, Luís M. Botana, Juan Botas, Chantal M. Boulanger, Michael E. Boulton, Mathieu Bourdenx, Benjamin Bourgeois, Nollaig M. Bourke, Guilhem Bousquet, Patricia Boya, Peter V. Bozhkov, Luiz H. M. Bozi, Tolga O. Bozkurt, Doug E. Brackney, Christian Brandts, Ralf J. Braun, Gerhard H. Braus, Roberto Bravo, José Manuel Bravo‐San Pedro, Patrick Brest, Marie-Agnès Bringer, Alfredo Briones‐Herrera, V. Courtney Broaddus, Peter Brodersen, Jeffrey L. Brodsky, Steven L. Brody, Paola G. Bronson, Jeff M. Bronstein, Carolyn N. Brown, Rhoderick E. Brown, Patrı́cia C. Brum, John H. Brumell, Nicola Brunetti‐Pierri, Daniele Bruno, Robert J. Bryson‐Richardson, Cecilia Bucci, Carmen Buchrieser, Marta Bueno, Laura Elisa Buitrago‐Molina, Simone Buraschi, Shilpa Buch, J. Ross Buchan, Erin M. Buckingham, Hikmet Budak, Mauricio Budini, Geert Bultynck, Florin Burada, Joseph R. Burgoyne, María I. Burón, Victor Bustos, Sabrina Büttner, Elena Butturini, Aaron Byrd, Isabel Cabas, Sandra Cabrera,
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, ...
Taylor & Francis
Daniel J. Klionsky, Fábio Camargo Abdalla, Hagai Abeliovich, Robert T. Abraham, Abraham Acevedo‐Arozena, Khosrow Adeli, Lotta Agholme, Maria Agnello, Patrizia Agostinis, Julio A. Aguirre‐Ghiso, Hyung Jun Ahn, Ouardia Aït-Mohamed, Slimane Ait‐Si‐Ali, Takahiko Akematsu, Shizuo Akira, Hesham M. Al‐Younes, Munir A. Al‐Zeer, Matthew L. Albert, Roger L. Albin, Javier Alegre‐Abarrategui, Maria Francesca Aleo, Mehrdad Alirezaei, Alexandru Almasan, Maylin Almonte‐Becerril, Atsuo Amano, Ravi K. Amaravadi, Shoba Amarnath, Amal O. Amer, Nathalie Andrieu‐Abadie, Vellareddy Anantharam, David K. Ann, Shailendra Anoopkumar‐Dukie, Hiroshi Aoki, Nadezda Apostolova, Giuseppe Arancia, John P. Aris, Katsuhiko Asanuma, Nana Asare, Hisashi Ashida, Valerie Askanas, David S. Askew, Patrick Auberger, Misuzu Baba, Steven K. Backues, Eric H. Baehrecke, Ben A. Bahr, Xue-Yuan Bai, Yannick Bailly, Robert A. Baiocchi, Giulia Baldini, Walter Balduini, Andrea Ballabio, Bruce A. Bamber, Edward T. W. Bampton, Gábor Juhász, Clinton R. Bartholomew, Diane C. Bassham, Robert C. Bast, Henri Batoko, Boon-Huat Bay, Isabelle Beau, Daniel Béchet, Thomas J. Begley, Christian Behl, Christian Behrends, Soumeya Bekri, Bryan H. Bellaire, Linda J. Bendall, Luca Benetti, Laura Berliocchi, Henri Bernardi, Francesca Bernassola, Sébastien Besteiro, Ingrid Bhatia-Kissova, Xiaoning Bi, Martine Biard-Piechaczyk, Janice S. Blum, Lawrence Boise, Paolo Bonaldo, David L. Boone, Beat Bornhäuser, Karina Ramalho Bortoluci, Ioannis Bossis, Frédéric Bost, Jean‐Pierre Bourquin, Patricia Boya, Michaël Boyer‐Guittaut, Peter V. Bozhkov, Nathan Brady, Claudio Brancolini, Andreas Brech, Jay E. Brenman, Ana Brennand, Emery Bresnick, Patrick Brest, Dave Bridges, Molly L. Bristol, Paul S. Brookes, Karen Brown, John H. Brumell, Nicola Brunetti‐Pierri, Ulf T. Brunk, Dennis E. Bulman, Scott J. Bultman, Geert Bultynck, Lena F. Burbulla, Wilfried Bursch, Jonathan P. Butchar, Wanda Buzgariu, Sérgio Paulo Bydlowski, Ken Cadwell, Monika Cahová, Jingjing Cai, Jiyang Cai, Qian Cai, Bruno Calabretta, Javier Calvo‐Garrido, Nadine Camougrand, Michelangelo Campanella, Jenny Campos‐Salinas, Eleonora Candi, Lizhi Cao, Allan B. Caplan, Simon R. Carding, Sandra M. Cardoso, Jennifer S. Carew, Cathleen R. Carlin, Virginie Carmignac, Leticia A.M. Carneiro, Serena Carra, Rosario A. Caruso, Giorgio Casari, Caty Casas, Roberta Castino, Eduardo Cebollero, Francesco Cecconi, Jean Celli, Hassan Chaachouay, Han‐Jung Chae, Chee‐Yin Chai, Min Chen, Edmond Y.W. Chan, Raymond Chuen‐Chung Chang, Chi‐Ming Che, Ching‐Chow Chen, Guang‐Chao Chen, Guo-Qiang Chen, Min Chen, Quan Chen, Steve S.-L. Chen, Wen‐Li Chen, Xi Chen, Xiangmei Chen, Xiequn Chen, Ye-Guang Chen, Yingyu Chen, Yongqiang Chen, Yu-Jen Chen, Zhixiang Chen, Alan Cheng, Christopher H.K. Cheng, Yan Cheng, Heesun Cheong, Jae‐Ho Cheong, Sara Cherry, Russ Chess‐Williams, Zelda H. Cheung, Éric Chevet, Hui-Ling Chiang, Roberto Chiarelli, Tomoki Chiba, Lih‐Shen Chin, Shih‐Hwa Chiou, Francis V. Chisari, Chi Hin Cho, Dong-Hyung Cho, Augustine M.K. Choi, DooSeok Choi, Kyeong Sook Choi, Mary E. Choi, Salem Chouaib, Vinay Choubey, Vinay Choubey, Charleen T. Chu, Tsung-Hsien Chuang, Sheau‐Huei Chueh, Taehoon Chun, Yong-Joon Chwae, Mee‐Len Chye, Roberto Ciarcia, Maria Rosa Ciriolo, Michael J. Clague, Robert Clark, Robert Clarke, Robert Clarke, Patrice Codogno, Hilary A. Coller, María I. Colombo, Sergio Comincini, Maria Condello, Fabrizio Condorelli, Mark Cookson, Graham H. Coombs, Isabelle Coppens, Ramón Corbalán, Pascale Cossart, Paola Costelli, Safia Costes, Ana Coto‐Montes, Eduardo Couve, Fraser P. Coxon, James M. Cregg, José L. Crespo, Marianne J. Cronjé, Ana María Cuervo, Joseph J. Cullen, Mark J. Czaja, Marcello D’Amelio, Arlette Darfeuille-Michaud, Lester M. Davids, Faith E. Davies, Massimo De Felici, John F. de Groot, Cornelis A. M. de Haan, Maria Antonietta De Matteis, Angelo De Milito, Daniela De Zio, Jayanta Debnath, Alexei Degterev, Benjamin Dehay, Lea M.D. Delbridge, Francesca Demarchi, Yi Deng, Jörn Dengjel, Paul Dent, Donna Denton, Vojo Deretić, Shyamal D. Desai, Rodney J. Devenish, Mario Di Gioacchino, Gilbert Di Paolo, Chiara Di Pietro, Inés Díaz‐Laviada, Inés Díaz‐Laviada, Marı́a T. Diaz-Meco, Javier Dı́az-Nido, Ivan Ðikić, Savithramma P. Dinesh-Kumar, Wen-Xing Ding, C W Distelhorst, Abhinav Diwan, Mojgan Djavaheri‐Mergny, Svetlana Dokudovskaya, Zheng Dong, Frank C. Dorsey, Victor Dosenko, James J. Dowling, Stephen Doxsey, Marlène Dreux, Mark E. Drew, Qiuhong Duan, Michel A. Duchosal, Karen Duff, Isabelle Dugail, Madeleine Durbeej, Michael Duszenko, Charles L. Edelstein, Aimee L. Edinger, Gustavo Egea, Ludwig Eichinger, N. Tony Eissa, Sühendan Ekmekçioglu, Wafik S. El‐Deiry, Zvulun Elazar, Mohamed Elgendy, Lisa M. Ellerby, Kai Er Eng, Anna‐Mart Engelbrecht, Simone Engelender, Rajaraman Eri, Ricardo Escalante, Audrey Esclatine, Eeva‐Liisa Eskelinen, Lucile Espert, Virginia Espina, Huizhou Fan, Jia Fan, Qi-Wen Fan, Zhen Fan, Shengyun Fang, Yongqi Fang, Manolis Fanto, Alessandro Fanzani, Thomas Farkas, Jean‐Claude Farré, Mathias Faure,
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues ...
Taylor & Francis
Peter Rossing, Ellen Burgess, Rajiv Agarwal, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Luís M. Ruilope, Pieter Gillard, Richard J. MacIsaac, Julio Wainstein, Amer Joseph, Meike Brinker, Lothar Roessig, Charlie Scott, George L. Bakris, Augusto Vallejos, Richard J. MacIsaac, Guntram Schernthaner, Pieter Gillard, Maria Eugênia Fernandes Canziani, Theodora Temelkova‐Kurktschiev, Ellen Burgess, Sheldon W. Tobe, Fernando González, Zhihong Liu, Andrés Ángelo, Cadena Bonfanti, Carlos Jaramillo, Martin Prázný, Peter Rossing, Jorma Strand, Michel Marre, Roland E. Schmieder, Christoph Wanner, Pantelis Sarafidis, Juliana C.N. Chan, László Rosivall, Joseph A. Eustace, Ehud Grossman, Yoram Yagil, Giuseppe Remuzzi, Daisuke Koya, Takashi Wada, Magdalena Madero Rovalo, Ron T. Gansevoort, Adriaan Kooy, Trine Finnes, Froilan De Leon, Janusz Gumprecht, Fernando Teixeira e Costa, Alexander Dreval, Anantharaman Vathsala, Aslam Amod, Sin Gon Kim, Byung‐Wan Lee, Julio Pascual Santos, Bengt-Olov Tengmark, Michel Burnier, Chien‐Te Lee, Sukit Yamwong, Ramazan Sarı, Kieran McCafferty, Borys Mankovsky, Sharon G. Adler, Linda P. Fried, Robert Toto, Mark V. Williams, Tran Quang Khanh, Diego Aizenberg, Inés Bartolacci, Diego Besada, Julio Bittar, Mariano Chahin, Alicia Elbert, Elizabeth Gelersztein, Alberto Liberman, Laura Maffei, Federico Pérez Manghi, Hugo Sanabria, Gloria Viñes, Alfredo Wassermann, Walter P. Abhayaratna, Shamasunder Acharya, Elif I. Ekinci, Darren Lee, Peak Mann Mah, Craig Nelson, David Packham, Alexia Pape, Simon D. Roger, Hugo Stephenson, Michael Suranyi, Gary Wittert, Elizabeth Vale, Martin Clodi, Christoph Ebenbichler, Evelyn Fließer-Görzer, Ursula Hanusch, Michael Krebs, Karl Lhotta, Bernhard Ludvik, Gert Mayer, Peter Neudorfer, Bernhard Paulweber, Rudolf Prager, Wolfgang Preiß, Friedrich C. Prischl, G. Schernthaner, Harald Sourij, Martin Wiesholzer, Peter Doubel, W. Engelen, Jean‐Michel Hougardy, Jean-Marie Krzesinski, Bart Maes, Marijn M. Speeckaert, Koen Stas, Luc Van Gaal, Hilde Vanbelleghem, Daniela Antunes, Roberto Botelho, Cláudia Brito, Luís Henrique Santos Canani, Maria Eugênia Fernandes Canziani, Maria Cerqueira, Rogério de Paula, Freddy G. Eliaschewitz, Carlos Eduardo Poli‐de‐Figueiredo, Adriana Costa e Forti, Miguel Nasser Hissa, Maurilo Leite, Emerson de Lima, Irene L. Noronha, Bruno Paolino, Nathalia Paschoalin, Raphael Paschoalin, Roberto Pécoits-Filho, Marcio Pereira, Evandro Portes, Dalton Bertolim Précoma, Rosângela Réa, Miguel C. Riella, João Eduardo Nunes Salles, Eduardo Vasconcellos, Sérgio Vencio, Emiliya Apostolova, Radostina Boshnyashka, Ghassan Farah, Dimitar Georgiev, Valentina Gushterova, Neli Klyuchkova, Mariya Lucheva, Petya Manova, Dotska Minkova, Boyan Nonchev, Mariyana Pichmanova, Zhulieta Prakova, Rangel Rangelov, Rosen Rashkov, Pavel Stanchev, Bilyana Stoyanovska-Elencheva, Zhivko Tagarev, Theodora Temelkova-Kurktschieva, S Vasileva, Mariana Yoncheva-Mihaylova, Paul E. Barré, Brian Carlson, James Conway, Serge Cournoyer, R Dumas, Sameh Fikry, Richard Goluch, Pavel Hamet, Randolph Hart, Sam Henein, Joanne Liutkus, François Madore, Valdemar Martinho, Giuseppe Mazza, Philip A. McFarlane, Dennis D. O’Keefe, Sean Peterson, Daniel M. Schwartz, Daniel Shu, Andrew Steele, Guy Tellier, Karthik Tennankore, George Tsoukas, Richard Tytus, Louise Vitou, Michael Walsh, S. John Weisnagel, Igor Wilderman, Jean‐François Yale, Jorge Cobos, Juan Godoy, Sergio Lobos, Juan Carlos Palma, Juan Carlos Prieto, Eliana Reyes, Carmen Romero, Víctor Saavedra, Mario Vega, Ruifang Bu, Cai H, Nan Chen, Qinkai Chen, Dejun Chen, Jinluo Cheng, Youping Dong, Junwu Dong, Tianjun Guan, Chuan‐Ming Hao, Wen Huang, Fangfang Jiang, Minxiang Lei, Ling Li, Zhonghe Li, Xuemei Li, Jingmei Li, Yan Li, Xinling Liang, Bo Liang, Fang Liu, Yinghong Liu, Yuan-Tao Liu, Zhihong Liu, Gang Long, Guoyuan Lu, Weiping Lu, Yibing Lu, Ping Luo, Jianhua Ma, Zhaohui Mo, Jianying Niu, Ai Peng, Jiansong Shen, Feixia Shen, Bingyin Shi, Qing Su, Zhuxing Sun, Shuifu Tang, Nanwei Tong, Hao Wang, Xinjun Wang, Lihua Wang, Guixia Wang, Jianqin Wang, Yangang Wang, Li Wang, Jiali Wei, Tianfeng Wu, Chao-Qing Wu, Xing Changying, Fei Xiong, Xudong Xu, Ning Xu, Tiekun Yan, Jin‐Kui Yang, Aiping Yin, Longyi Zeng, Hao Zhang, Yanlin Zhang, Ying Zhang, Wenjing Zhao, Zhiquan Zhao, Hongguang Zheng, Ling Zhong, Dalong Zhu, Yongze Zhuang, Clara Arango, Sandra Barrera, Nelly Beltrán López, Diego Benitez, Guillermo Blanco, Andrés Cadena, Julián Coronel, Carlos Cure, Carlos Durán, Alexander Ariel Padrón González, Gustavo Guzmán, Eric Hernández, Jaime Ibarra, Carlos Jaramillo, Nicolás Jaramillo, William Kattah, Dora I. Molina, Gregorio Sánchez, Mónica Terront, Freddy Trujillo, Miguel Urina‐Triana, Ruben Vargas, Iván Villegas, Hernán Yupanqui, D Alferi, Michal Brada,
Finerenone significantly improved cardiorenal outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) in the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease trial. We explored whether baseline HbA1c level and insulin treatment influenced outcomes.Patients with T2D, urine albumin-to-creatinine ratio (UACR) of 30-5,000 mg/g, estimated glomerular filtration rate (eGFR) of 25 to <75 mL/min/1.73 m2, and treated with optimized renin-angiotensin ...
American Diabetes Association
Peter Rossing, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Luís M. Ruilope, Andreas L. Birkenfeld, Janet B. McGill, Sylvia E. Rosas, Amer Joseph, Martin Gebel, Luke Roberts, Markus F. Scheerer, George L. Bakris, Rajiv Agarwal, Diego Aizenberg, Inés Bartolacci, Diego Besada, Julio Bittar, Mariano Chahin, Alicia Elbert, Elizabeth Gelersztein, Alberto Liberman, Laura Maffei, Federico Pérez Manghi, Hugo Sanabria, Augusto Vallejos, Gloria Viñes, Alfredo Wassermann, Walter P. Abhayaratna, Shamasunder Acharya, Elif I. Ekinci, Darren Lee, Richard J. MacIsaac, Peak Mann Mah, Craig Nelson, David Packham, Alexia Pape, Simon D. Roger, Hugo Stephenson, Michael Suranyi, Gary Wittert, Elizabeth Vale, Peter G. Colman, David Colquhoun, Chris Ellis, Kim Joshua, Eugenia Pedagogos, Paul Regal, Duncan J. Topliss, James Vandeleur, Johan Verjans, Gary Wittert, Katie-Jane Wynne, Martin Clodi, Christoph Ebenbichler, Evelyn Fließer-Görzer, Ursula Hanusch, Michael Krebs, Karl Lhotta, Bernhard Ludvik, Gert Mayer, Peter Neudorfer, Bernhard Paulweber, Rudolf Prager, Wolfgang Preiß, Friedrich C. Prischl, G. Schernthaner, Harald Sourij, Martin Wiesholzer, Heinz Drexel, Rainer Oberbauer, Hans‐Robert Schönherr, Peter Doubel, W. Engelen, Pieter Gillard, Jean‐Michel Hougardy, Jean-Marie Krzesinski, Bart Maes, Marijn M. Speeckaert, Koen Stas, Luc Van Gaal, Hilde Vanbelleghem, Francis Duyck, André Scheen, Daniela Antunes, Roberto Botelho, Cláudia Brito, Luís Henrique Santos Canani, Maria Eugênia Fernandes Canziani, Maria Cerqueira, Rogério de Paula, Freddy G. Eliaschewitz, Carlos Eduardo Poli‐de‐Figueiredo, Adriana Costa e Forti, Miguel Nasser Hissa, Maurilo Leite, Emerson de Lima, Irene L. Noronha, Bruno Paolino, Nathalia Paschoalin, Raphael Paschoalin, Roberto Pécoits-Filho, Marcio Pereira, Evandro Portes, Dalton Bertolim Précoma, Rosângela Réa, Miguel C. Riella, João Eduardo Nunes Salles, Eduardo Vasconcellos, Sérgio Vencio, Marcelo Rodrigues Bacci, Lília Nigro Maia, Aline Sterque Villacorta, Emiliya Apostolova, Radostina Boshnyashka, Ghassan Farah, Dimitar Georgiev, Valentina Gushterova, Neli Klyuchkova, Mariya Lucheva, Petya Manova, Dotska Minkova, Boyan Nonchev, Mariyana Pichmanova, Zhulieta Prakova, Rangel Rangelov, Rosen Rashkov, Pavel Stanchev, Bilyana Stoyanovska-Elencheva, Zhivko Tagarev, Theodora Temelkova-Kurktschieva, S Vasileva, Mariana Yoncheva-Mihaylova, Angel Marinchev, Mariya Miteva, Paul E. Barré, Brian Carlson, James Conway, Serge Cournoyer, R Dumas, Sameh Fikry, Richard Goluch, Pavel Hamet, Randolph Hart, Sam Henein, Joanne Liutkus, François Madore, Valdemar Martinho, Giuseppe Mazza, Philip A. McFarlane, Dennis D. O’Keefe, Sean D. Peterson, Daniel Schwartz, Daniel Shu, Andrew Steele, Guy Tellier, Karthik Tennankore, Sheldon W. Tobe, George Tsoukas, Richard Tytus, Louise Vitou, Michael Walsh, S. John Weisnagel, Igor Wilderman, Jean‐François Yale, Fadia El Boreky, Alan Kelly, Lawrence A. Leiter, Ivor Teitelbaum, Jorge Cobos, Juan Godoy, Fernando González, Sergio Lobos, Juan Carlos Palma, Juan Carlos Prieto Dominguez, Eliana Reyes, Carmen Romero, Víctor Saavedra, Mario Vega, Marcelo Gabriel Medina, Paola Varleta, Ruifang Bu, Cai H, Nan Chen, Qinkai Chen, Dejun Chen, Jinluo Cheng, Youping Dong, Junwu Dong, Tianjun Guan, Chuan‐Ming Hao, Wen Huang, Fangfang Jiang, Minxiang Lei, Ling Li, Zhonghe Li, Xuemei Li, Jingmei Li, Yan Li, Xinling Liang, Bo Liang, Fang Liu, Yinghong Liu, Yuantao Liu, Zhihong Liu, Gang Long, Guoyuan Lu, Weiping Lu, Yibing Lu, Ping Luo, Jianhua Ma, Zhaohui Mo, Jianying Niu, Ai Peng, Jiansong Shen, Feixia Shen, Bingyin Shi, Qing Su, Zhuxing Sun, Shuifu Tang, Nanwei Tong, Hao Wang, Xinjun Wang, Guixia Wang, Jianqin Wang, Yangang Wang, Li Wang, Jiali Wei, Tianfeng Wu, Chao-Qing Wu, Xing Changying, Fei Xiong, Xudong Xu, Ning Xu, Tiekun Yan, Jinkui Yang, Aiping Yin, Longyi Zeng, Hao Zhang, Yanlin Zhang, Ying Zhang, Wenjing Zhao, Zhiquan Zhao, Hongguang Zheng, Ling Zhong, Dalong Zhu, Yongze Zhuang, Yuming Du, Yi Fang, Weiying Guo, Sheng Jiang, Jian Kuang, Dongmei Li, Hongmei Li, Yinan Li, Yuxiu Li, Liu Jian, Yu Liu, Heng Miao, Wen Peng, Lihua Wang, Mingtong Xu, Liyong Zhong, Jun Zhu, Clara Arango, Sandra Barrera, Nelly Beltrán López, Diego Benitez, Guillermo Blanco, Andrés Cadena, Julián Coronel, Carlos Cure, Carlos E. Durán, Alexander Ariel Padrón González, Gustavo Guzmán, Eric Hernández, Jaime Ibarra, Carlos Jaramillo, Nicolás Jaramillo, William Kattah, Dora I. Molina, Gregorio Sánchez, Mónica Terront, Freddy Trujillo, Miguel Urina‐Triana, Ruben Vargas, Iván Villegas, Hernán Yupanqui, Édgar Arcos, Gustavo Aroca, Germán Barreto, Andrés Bermúdez, Rodrigo Botero, Tatiana Cárdenas, Wilmer Figueroa, Mónica Jaramillo,
Finerenone reduced the risk of kidney and cardiovascular events in people with chronic kidney disease (CKD) and type 2 diabetes in the FIDELIO-DKD and FIGARO-DKD phase 3 studies. Effects of finerenone on outcomes in patients taking sodium-glucose cotransporter 2 inhibitors (SGLT2is) were evaluated in a prespecified pooled analysis of these studies.Patients with type 2 diabetes and urine albumin-to-creatinine ratio (UACR) ≥30 to ≤5,000 mg/g and estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 ...
American Diabetes Association
Produção Nacional
Revisado por pares
Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O’Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, Roberto A. Barrero, Takuro Tamura, Yumi Yamaguchi‐Kabata, Motohiko Tanino, Kei Yura, Satoru Miyazaki, Kazuho Ikeo, Keiichi Homma, Arek Kasprzyk, Tetsuo Nishikawa, Mika Hirakawa, Jean Thierry‐Mieg, Danielle Thierry‐Mieg, Jennifer Ashurst, Libin Jia, Mitsuteru Nakao, Michael A. Thomas, Nicola Mulder, Youla Karavidopoulou, Lihua Jin, Sangsoo Kim, Tomohiro Yasuda, Boris Lenhard, Éric Eveno, Yoshiyuki Suzuki, Chisato Yamasaki, Jun‐ichi Takeda, Craig A. Gough, Phillip B. Hilton, Yasuyuki Fujii, Hiroaki Sakai, Susumu Tanaka, Clara Amid, M. Bellgard, Maria de Fátima Bonaldo, Hidemasa Bono, Susan K. Bromberg, Anthony J. Brookes, Elspeth A. Bruford, Piero Carninci, Claude Chelala, C Couillault, Sandro J. de Souza, Marie-Anne Debily, Marie‐Dominique Devignes, Inna Dubchak, Toshinori Endo, Anne Estreicher, Eduardo Eyras, Kaoru Fukami-Kobayashi, Gopal Gopinath, Esther Graudens, Yoonsoo Hahn, Michael Han, Ze‐Guang Han, Kousuke Hanada, Hideki Hanaoka, Erimi Harada, Katsuyuki Hashimoto, Ursula Hinz, Momoki Hirai, Teruyoshi Hishiki, Ian Hopkinson, Sandrine Imbeaud, Hidetoshi Inoko, Alexander Kanapin, Yayoi Kaneko, Takeya Kasukawa, Janet Kelso, Paul Kersey, Reiko Kikuno, Kouichi Kimura, Bernhard Korn, Vladimir Kuryshev, Izabela Makałowska, Takashi Makino, Shuhei Mano, Régine Mariage‐Samson, Jun Mashima, Hideo Matsuda, Hans‐Werner Mewes, Satoshi Minoshima, Keiichi Nagai, Hideki Nagasaki, Naoki Nagata, Rajni Nigam, Osamu Ogasawara, Osamu Ohara, Masafumi Ohtsubo, Norihiro Okada, Toshihisa Okido, Satoshi Oota, Motonori Ota, Toshio Ota, Tetsuji Otsuki, Dominique Piatier‐Tonneau, Annemarie Poustka, Shuangxi Ren, Naruya Saitou, Katsunaga Sakai, Shigetaka Sakamoto, Ryuichi Sakate, Ingo Schupp, Florence Servant, Stephen T. Sherry, Rie Shiba, Nobuyoshi Shimizu, Mary Shimoyama, Andrew J.G. Simpson, Bento Soares, Charles A. Steward, Makiko Suwa, Mami Suzuki, Aiko Takahashi, Gen Tamiya, Hiroshi Tanaka, Todd D. Taylor, Joseph D. Terwilliger, Per Unneberg, Vamsi Veeramachaneni, Shinya Watanabe, Laurens Wilming, Norikazu Yasuda, Hyang‐Sook Yoo, Marvin Stodolsky, Wojciech Makałowski, Mitiko Gō, Kenta Nakai, Toshihisa Takagi, Minoru Kanehisa, Yoshiyuki Sakaki, John Quackenbush, Yasushi Okazaki, Yoshihide Hayashizaki, Yoshihide Hayashizaki, Ranajit Chakraborty, Ken Nishikawa, Hideaki Sugawara, Yoshio Tateno, Zhu Chen, Michio Oishi, Peter J. Tonellato, Rolf Apweiler, Kousaku Okubo, Lukas Wagner, Stefan Wiemann, Robert L. Strausberg, Takao Isogai, Charles Auffray, Nobuo Nomura, Takashi Gojobori, Sumio Sugano,
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative ...
Tópico(s): Machine Learning in Bioinformatics
2004 - Public Library of Science | PLoS Biology
Jack Dongarra, Pete Beckman, Terry Moore, Patrick Aerts, Giovanni Aloisio, Jean–Claude André, D. Barkai, Jean-Yves Berthou, Taisuke Boku, Bertrand Braunschweig, Franck Cappello, Barbara Chapman, Xuebin Chi, Alok Choudhary, Sudip S. Dosanjh, Thom H. Dunning, Sandro Fiore, Al Geist, William Gropp, Robert J. Harrison, Mark Hereld, Michael A. Heroux, Adolfy Hoisie, Koh Hotta, Zhong Jin, Yutaka Ishikawa, Fred Johnson, Sanjay Kale, R.D. Kenway, David E. Keyes, Bill Kramer, Jesús Labarta, A. Lichnewsky, Thomas Lippert, Bob Lucas, Arthur B. Maccabe, Satoshi Matsuoka, Paul Messina, Peter Michielse, Bernd Mohr, Matthias Mueller, Wolfgang E. Nagel, Hiroshi Nakashima, Michael E. Papka, Dan Reed, Mitsuhisa Sato, Ed Seidel, John Shalf, David Skinner, Marc Snir, Thomas Sterling, Rick Stevens, Frederick H. Streitz, Bob Sugar, Shinji Sumimoto, W. M. Tang, John C Taylor, Rajeev Thakur, Anne Trefethen, Mateo Valero, Aad van der Steen, Jeffrey S. Vetter, Peg Williams, Robert W. Wisniewski, Kathy Yelick,
Over the last 20 years, the open-source community has provided more and more software on which the world’s high-performance computing systems depend for performance and productivity. The community has invested millions of dollars and years of effort to build key components. However, although the investments in these separate software elements have been tremendously valuable, a great deal of productivity has also been lost because of the lack of planning, coordination, and key integration of technologies ...
Tópico(s): Advanced Data Storage Technologies
2011 - SAGE Publishing | The International Journal of High Performance Computing Applications
Yilong Li, Nicola D. Roberts, Jeremiah A. Wala, Ofer Shapira, Steven E. Schumacher, Kiran Kumar, Ekta Khurana, Sebastian M. Waszak, Jan O. Korbel, James E. Haber, Marcin Imieliński, Kadir C. Akdemir, Eva G. Álvarez, Adrian Baez‐Ortega, Rameen Beroukhim, Paul C. Boutros, David D.L. Bowtell, Benedikt Brors, Kathleen H. Burns, Peter J. Campbell, Kin Chan, Ken Chen, Isidro Cortés‐Ciriano, Ana Dueso-Barroso, Andrew Dunford, Paul A. Edwards, Xavier Estivill, Dariush Etemadmoghadam, Lars Feuerbach, J. Lynn Fink, Milana Frenkel‐Morgenstern, Dale W. Garsed, Mark Gerstein, Dmitry A. Gordenin, David Haan, James E. Haber, Julian M. Hess, Barbara Hutter, Marcin Imieliński, David Jones, Young Seok Ju, Marat D. Kazanov, Leszek J. Klimczak, Youngil Koh, Jan O. Korbel, Kiran Kumar, Eunjung Alice Lee, Jake June-Koo Lee, Yilong Li, Andy G. Lynch, Geoff Macintyre, Florian Markowetz, Iñigo Martincorena, Alexander Martínez-Fundichely, Matthew Meyerson, Satoru Miyano, Hidewaki Nakagawa, Fábio C. P. Navarro, Stephan Ossowski, Peter J. Park, John V. Pearson, Montserrat Puiggròs, Karsten Rippe, Nicola D. Roberts, Steven A. Roberts, Bernardo Rodríguez–Martín, Steven E. Schumacher, Ralph Scully, Mark Shackleton, Nikos Sidiropoulos, Lina Sieverling, Chip Stewart, David Torrents, José M. C. Tubío, Izar Villasante, Nicola Waddell, Jeremiah A. Wala, Joachim Weischenfeldt, Lixing Yang, Xiaotong Yao, Sung-Soo Yoon, Jorge Zamora, Cheng‐Zhong Zhang, Joachim Weischenfeldt, Rameen Beroukhim, Peter J. Campbell, Lauri A. Aaltonen, Federico Abascal, Adam Abeshouse, Hiroyuki Aburatani, David J. Adams, Nishant Agrawal, Keun Soo Ahn, Sung‐Min Ahn, Hiroshi Aikata, Rehan Akbani, Kadir C. Akdemir, Hikmat Al‐Ahmadie, Sultan T. Al‐Sedairy, Fátima Al‐Shahrour, Malik Alawi, Monique Albert, Kenneth Aldape, Ludmil B. Alexandrov, Adrian Ally, Kathryn Alsop, Eva G. Álvarez, Fernanda Amary, Samirkumar B. Amin, Brice Aminou, Ole Ammerpohl, Matthew J. Anderson, Yeng Ang, Davide Antonello, Pavana Anur, Samuel Aparício, Elizabeth L. Appelbaum, Yasuhito Arai, Axel Aretz, Koji Arihiro, Shun‐ichi Ariizumi, Joshua Armenia, Laurent Arnould, L. Sylvia, Yassen Assenov, Gurnit Atwal, Sietse Aukema, J. Todd Auman, Miriam R. R. Aure, Philip Awadalla, Marta Aymerich, Gary D. Bader, Adrian Baez‐Ortega, Peter J. Bailey, Peter J. Bailey, Miruna Balasundaram, Saianand Balu, Pratiti Bandopadhayay, Rosamonde E. Banks, Stefano Barbi, Andrew P. Barbour, Jonathan Barenboim, Jill S. Barnholtz‐Sloan, Hugh Barr, Elisabet Barrera, John G. Bartlett, Javier Bartolomé, Claudio Bassi, Oliver F. Bathe, Daniel Baumhoer, Prashant Bavi, Stephen B. Baylin, Wojciech Bażant, Duncan Beardsmore, Timothy A. Beck, Sam Behjati, Andreas Behren, Beifang Niu, Cindy Bell, Sergi Beltrán, Christopher C. Benz, Andrew Berchuck, Anke K. Bergmann, Erik N. Bergstrom, Benjamin P. Berman, Daniel M. Berney, Stephan Wolf, Rameen Beroukhim, Mario Berríos, Samantha Bersani, Johanna Bertl, Miguel Betancourt, Vinayak Bhandari, Shriram G. Bhosle, Andrew V. Biankin, Matthias Bieg, Darell D. Bigner, Hans Binder, Ewan Birney, Michael J. Birrer, Nidhan K. Biswas, Bodil Bjerkehagen, Tom Bodenheimer, Lori Boice, Giada Bonizzato, Johann S. de Bono, Arnoud Boot, Arnoud Boot, Åke Borg, Arndt Borkhardt, Keith A. Boroevich, Ivan Borozan, Christoph W. Borst, Marcus Bosenberg, Mattia Bosio, Jacqueline Boultwood, Guillaume Bourque, Paul C. Boutros, G. Steven Bova, David Bowen, Reanne Bowlby, David D.L. Bowtell, Sandrine Boyault, Rich Boyce, Jeffrey M. Boyd, Alvis Brāzma, Paul E. Brennan, Daniel Brewer, Arie B. Brinkman, Robert G. Bristow, Russell R. Broaddus, Jane E. Brock, Malcolm V. Brock, Annegien Broeks, Angela N. Brooks, Denise Brooks, Benedikt Brors, Søren Brunak, Timothy J. C. Bruxner, Alicia L. Bruzos, Alex Buchanan, Ivo Buchhalter, Christiane Buchholz, Susan Bullman, Hazel Burke, Birgit Burkhardt, Kathleen H. Burns, John Busanovich, Carlos D. Bustamante, Adam P. Butler, Atul J. Butte, Niall J. Byrne, Anne‐Lise Børresen‐Dale, Rory Johnson, Andy Cafferkey, Declan Cahill, Claudia Calabrese, Carlos Caldas, Fabien Calvo, Niedzica Camacho, Peter J. Campbell, Elı́as Campo, Cinzia Cantù, Shaolong Cao, Thomas E. Carey, Joana Carlevaro-Fita, Rebecca Carlsen, Ivana Cataldo, Mario Cazzola, Jonathan Cebon, Robert J. Cerfolio, Dianne Chadwick, Dimple Chakravarty, Drc Chalmers, Calvin Wing Yiu Chan, Kin Chan, Michelle Chan‐Seng‐Yue, Vishal S. Chandan, David K. Chang, Stephen J. Chanock, Keiran Raine, Aurélien Chateigner, Nilanjan Chatterjee, Kazuaki Chayama, Hsiao-Wei Chen, Jieming Chen, Ken Chen, Yiwen Chen, Zhaohong Chen, Andrew D. Cherniack, Jeremy Chien, Yoke-Eng Chiew, Suet‐Feung Chin, Juok Cho, Sunghoon Cho, Jung Kyoon Choi, Wan Choi, Christine Chomienne, Zechen Chong, Su Pin Choo, Angela Chou, Angelika N. Christ, Elizabeth L. Christie, Eric Chuah, Carrie Cibulskis, Kristian Cibulskis, Sara Cingarlini, Peter Clapham, Alexander Claviez, Sean P. Cleary, Nicole Cloonan, Marek Cmero, Colin C. Collins, Ashton A. Connor, Susanna L. Cooke, Colin S. Cooper,
Abstract A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes 1–7 . Here we develop methods to group, classify and describe somatic structural variants, using data from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 ...
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Marc Zapatka, Ivan Borozan, Daniel Brewer, Murat Iskar, Adam Grundhoff, Malik Alawi, Nikita Desai, Holger Sültmann, Holger Moch, Malik Alawi, Ivan Borozan, Daniel Brewer, Colin S. Cooper, Nikita Desai, Roland Eils, Vincent Ferretti, Adam Grundhoff, Murat Iskar, Kortine Kleinheinz, Peter Lichter, Hidewaki Nakagawa, Akinyemi I. Ojesina, Chandra Sekhar Pedamallu, Matthias Schlesner, Xiaoping Su, Marc Zapatka, Colin S. Cooper, Roland Eils, Vincent Ferretti, Peter Lichter, Lauri A. Aaltonen, Federico Abascal, Adam Abeshouse, Hiroyuki Aburatani, David J. Adams, Nishant Agrawal, Keun Soo Ahn, Sung‐Min Ahn, Hiroshi Aikata, Rehan Akbani, Kadir C. Akdemir, Hikmat Al‐Ahmadie, Sultan T. Al‐Sedairy, Fátima Al‐Shahrour, Malik Alawi, Monique Albert, Kenneth Aldape, Ludmil B. Alexandrov, Adrian Ally, Kathryn Alsop, Eva G. Álvarez, Fernanda Amary, Samirkumar B. Amin, Brice Aminou, Ole Ammerpohl, Matthew J. Anderson, Yeng Ang, Davide Antonello, Pavana Anur, Samuel Aparício, Elizabeth L. Appelbaum, Yasuhito Arai, Axel Aretz, Koji Arihiro, Shun‐ichi Ariizumi, Joshua Armenia, Laurent Arnould, L. Sylvia, Yassen Assenov, Gurnit Atwal, Sietse Aukema, J. Todd Auman, Miriam R. R. Aure, Philip Awadalla, Marta Aymerich, Gary D. Bader, Adrian Baez‐Ortega, Peter J. Bailey, Peter J. Bailey, Miruna Balasundaram, Saianand Balu, Pratiti Bandopadhayay, Rosamonde E. Banks, Stefano Barbi, Andrew P. Barbour, Jonathan Barenboim, Jill S. Barnholtz‐Sloan, Hugh Barr, Elisabet Barrera, John Bartlett, Javier Bartolomé, Claudio Bassi, Oliver F. Bathe, Daniel Baumhoer, Prashant Bavi, Stephen B. Baylin, Wojciech Bażant, Duncan Beardsmore, Tim Beck, Sam Behjati, Andreas Behren, Beifang Niu, Cindy Bell, Sergi Beltrán, Christopher C. Benz, Andrew Berchuck, Anke Bergmann, Erik N. Bergstrom, Benjamin P. Berman, Daniel M. Berney, Stephan Wolf, Rameen Beroukhim, Mario Berríos, Samantha Bersani, Johanna Bertl, Miguel Betancourt, Vinayak Bhandari, Shriram G. Bhosle, Andrew V. Biankin, Matthias Bieg, Darell D. Bigner, Hans Binder, Ewan Birney, Michael J. Birrer, Nidhan K. Biswas, Bodil Bjerkehagen, Tom Bodenheimer, Lori Boice, Giada Bonizzato, Johann S. de Bono, Arnoud Boot, Arnoud Boot, Åke Borg, Arndt Borkhardt, Keith A. Boroevich, Ivan Borozan, Christoph W. Borst, Marcus Bosenberg, Mattia Bosio, Jacqueline Boultwood, Guillaume Bourque, Paul C. Boutros, G. Steven Bova, David Bowen, Reanne Bowlby, David D.L. Bowtell, Sandrine Boyault, Rich Boyce, Jeffrey M. Boyd, Alvis Brāzma, Paul M. Brennan, Daniel Brewer, Arie B. Brinkman, Robert G. Bristow, Russell R. Broaddus, Jane E. Brock, Malcolm V. Brock, Annegien Broeks, Angela N. Brooks, Denise Brooks, Benedikt Brors, Søren Brunak, Timothy J. C. Bruxner, Alicia L. Bruzos, Alex Buchanan, Ivo Buchhalter, Christiane Buchholz, Susan Bullman, Hazel Burke, Birgit Burkhardt, Kathleen H. Burns, John Busanovich, Carlos D. Bustamante, Adam P. Butler, Atul J. Butte, Niall J. Byrne, Anne‐Lise Børresen‐Dale, Rory Johnson, Andy Cafferkey, Declan Cahill, Claudia Calabrese, Carlos Caldas, Fabien Calvo, Niedzica Camacho, Peter J. Campbell, Elı́as Campo, Cinzia Cantù, Shaolong Cao, Thomas E. Carey, Joana Carlevaro-Fita, Rebecca Carlsen, Ivana Cataldo, Mario Cazzola, Jonathan Cebon, Robert Cerfolio, Dianne Chadwick, Dimple Chakravarty, Drc Chalmers, Calvin Wing Yiu Chan, Kin Chan, Michelle Chan‐Seng‐Yue, Vishal S. Chandan, David K. Chang, Stephen J. Chanock, Keiran Raine, Aurélien Chateigner, Nilanjan Chatterjee, Kazuaki Chayama, Hsiao-Wei Chen, Jieming Chen, Ken Chen, Yiwen Chen, Zhaohong Chen, Andrew D. Cherniack, Jeremy Chien, Yoke-Eng Chiew, Suet‐Feung Chin, Juok Cho, Sunghoon Cho, Jung Kyoon Choi, Wan Choi, Christine Chomienne, Zechen Chong, Su Pin Choo, Angela Chou, Angelika N. Christ, Elizabeth L. Christie, Eric Chuah, Carrie Cibulskis, Kristian Cibulskis, Sara Cingarlini, Peter Clapham, Alexander Claviez, Sean P. Cleary, Nicole Cloonan, Marek Cmero, Colin C. Collins, Ashton A. Connor, Susanna L. Cooke, Colin S. Cooper, Leslie Cope, Vincenzo Corbo, Matthew G. Cordes, Stephen Cordner, Isidro Cortés‐Ciriano, Kyle R. Covington, Prue A. Cowin, Brian Craft, David Craft, Chad J. Creighton, Yupeng Cun, Erin Curley, Ioana Cutcutache, Karolina Czajka, Bogdan Czerniak, Rebecca A. Dagg, Ludmila Danilova, Maria Vittoria Davì, Natalie R. Davidson, Helen Davies, Ian J. Davis, Brandi N. Davis‐Dusenbery, Kevin J. Dawson, Francisco M. De La Vega, Ricardo De Paoli‐Iseppi, Timothy Defreitas, Angelo Paolo Dei Tos, Olivier Delaneau, John A. Demchok, Jonas Demeulemeester, German Demidov, Deniz Demircioğlu, Nening M. Dennis, Robert E. Denroche, Stefan C. Dentro, Nikita Desai, Vikram Deshpande, Amit G. Deshwar, Christine Desmedt, Jordi Deu-Pons, Noreen Dhalla, Neesha C. Dhani, Priyanka Dhingra, Rajiv Dhir, Anthony DiBiase, Klev Diamanti, Li Ding, Shimin Shuai, Huy Q. Dinh, Luc Dirix, HarshaVardhan Doddapaneni, Nilgun Donmez, Michelle T. Dow, Ronny Drapkin, Oliver Drechsel, Ruben M. Drews,
Abstract Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome datasets. We found a high prevalence of known tumor-associated viruses such as Epstein–Barr virus ( ...
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Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Jeremiah A. Wala, Ofer Shapira, Grace Tiao, Henrik Hornshøj, Julian M. Hess, Randi Istrup Juul, Ziao Lin, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andrés Lanzós, Carl Herrmann, Yosef E. Maruvka, Ciyue Shen, Samirkumar B. Amin, Pratiti Bandopadhayay, Johanna Bertl, Keith A. Boroevich, John Busanovich, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, David Craft, Priyanka Dhingra, Klev Diamanti, Nuno A. Fonseca, Abel González-Pérez, Qianyun Guo, Mark P. Hamilton, Nicholas J. Haradhvala, Hong Chen, Keren Isaev, Todd A. Johnson, Malene Juul, André Kahles, Abdullah Kahraman, Young-Wook Kim, Jan Komorowski, Kiran Kumar, Sushant Kumar, Donghoon Lee, Kjong-Van Lehmann, Yilong Li, Eric Minwei Liu, Lucas Lochovsky, Keunchil Park, Oriol Pich, Nicola D. Roberts, Gordon Saksena, Steven E. Schumacher, Nikos Sidiropoulos, Lina Sieverling, Nasa Sinnott-Armstrong, Chip Stewart, David Tamborero, José M. C. Tubío, Husen M. Umer, Liis Uusküla-Reimand, Claes Wadelius, Lina Wadi, Xiaotong Yao, Cheng‐Zhong Zhang, Jing Zhang, James E. Haber, Asger Hobolth, Marcin Imieliński, Manolis Kellis, Michael S. Lawrence, Christian von Mering, Hidewaki Nakagawa, Benjamin J. Raphael, Mark A. Rubin, Chris Sander, Lincoln D. Stein, Joshua M. Stuart, Tatsuhiko Tsunoda, David A. Wheeler, Rory Johnson, Jüri Reimand, Mark Gerstein, Ekta Khurana, Peter J. Campbell, Núria López-Bigas, Federico Abascal, Samirkumar B. Amin, Gary D. Bader, Pratiti Bandopadhayay, Jonathan Barenboim, Rameen Beroukhim, Johanna Bertl, Keith A. Boroevich, Søren Brunak, Peter J. Campbell, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, Ken Chen, Jung Kyoon Choi, Jordi Deu-Pons, Priyanka Dhingra, Klev Diamanti, Lars Feuerbach, J. Lynn Fink, Nuno A. Fonseca, Joan Frigola, Carlo Gambacorti‐Passerini, Dale W. Garsed, Mark Gerstein, Gad Getz, Qianyun Guo, Marta Gut, David Haan, Mark P. Hamilton, Nicholas J. Haradhvala, Arif O. Harmanci, Mohamed Helmy, Carl Herrmann, Julian M. Hess, Asger Hobolth, Ermin Hodzic, Hong Chen, Henrik Hornshøj, Keren Isaev, José M. G. Izarzugaza, Rory Johnson, Todd A. Johnson, Malene Juul, Randi Istrup Juul, André Kahles, Abdullah Kahraman, Manolis Kellis, Ekta Khurana, Jaegil Kim, Jong-Kwang Kim, Young-Wook Kim, Jan Komorowski, Jan O. Korbel, Sushant Kumar, Andrés Lanzós, Erik Larsson, Michael S. Lawrence, Donghoon Lee, Kjong-Van Lehmann, Shantao Li, Xiaotong Li, Ziao Lin, Eric Minwei Liu, Lucas Lochovsky, Shaoke Lou, Tobias Madsen, Kathleen Marchal, Iñigo Martincorena, Alexander Martínez-Fundichely, Yosef E. Maruvka, Patrick D. McGillivray, William Meyerson, Ferran Muiños, Loris Mularoni, Hidewaki Nakagawa, Morten Muhlig Nielsen, Marta Paczkowska, Keunchil Park, Kiejung Park, Jakob Skou Pedersen, Tirso Pons, Sergio Pulido-Tamayo, Benjamin J. Raphael, Jüri Reimand, Iker Reyes-Salazar, Matthew A. Reyna, Esther Rheinbay, Mark A. Rubin, Carlota Rubio-Pérez, S. Cenk Sahinalp, Gordon Saksena, Leonidas Salichos, Chris Sander, Steven E. Schumacher, Mark Shackleton, Ofer Shapira, Ciyue Shen, Raunak Shrestha, Shimin Shuai, Nikos Sidiropoulos, Lina Sieverling, Nasa Sinnott-Armstrong, Lincoln D. Stein, Joshua M. Stuart, David Tamborero, Grace Tiao, Tatsuhiko Tsunoda, Husen M. Umer, Liis Uusküla-Reimand, Alfonso Valencia, Miguel Vazquez, Lieven P. C. Verbeke, Claes Wadelius, Lina Wadi, Jiayin Wang, Jonathan Warrell, Sebastian M. Waszak, Joachim Weischenfeldt, David A. Wheeler, Guanming Wu, Jun Yu, Jing Zhang, Xuanping Zhang, Yan Zhang, Zhongming Zhao, Lihua Zou, Christian von Mering, Kadir C. Akdemir, Eva G. Álvarez, Adrian Baez‐Ortega, Rameen Beroukhim, Paul C. Boutros, David D.L. Bowtell, Benedikt Brors, Kathleen H. Burns, John Busanovich, Peter J. Campbell, Kin Chan, Ken Chen, Isidro Cortés‐Ciriano, Ana Dueso-Barroso, Andrew Dunford, Paul A. Edwards, Xavier Estivill, Dariush Etemadmoghadam, Lars Feuerbach, J. Lynn Fink, Milana Frenkel‐Morgenstern, Dale W. Garsed, Mark Gerstein, Dmitry A. Gordenin, David Haan, James E. Haber, Julian M. Hess, Barbara Hutter, Marcin Imieliński, David Jones, Young Seok Ju, Marat D. Kazanov, Leszek J. Klimczak, Youngil Koh, Jan O. Korbel, Kiran Kumar, Eunjung Alice Lee, Jake June-Koo Lee, Yilong Li, Andy G. Lynch, Geoff Macintyre, Florian Markowetz, Iñigo Martincorena, Alexander Martínez-Fundichely, Matthew Meyerson, Satoru Miyano, Hidewaki Nakagawa, Fábio C. P. Navarro, Stephan Ossowski, Peter J. Park, John V. Pearson, Montserrat Puiggròs, Karsten Rippe, Nicola D. Roberts, Steven A. Roberts, Bernardo Rodríguez–Martín, Steven E. Schumacher, Ralph Scully, Mark Shackleton, Nikos Sidiropoulos, Lina Sieverling, Chip Stewart, David Torrents, José M. C. Tubío, Izar Villasante, Nicola Waddell, Jeremiah A. Wala, Joachim Weischenfeldt, Lixing Yang, Xiaotong Yao, Sung-Soo Yoon, Jorge Zamora, Cheng‐Zhong Zhang, Joachim Weischenfeldt, Rameen Beroukhim, Iñigo Martincorena, Jakob Skou Pedersen, Gad Getz, Lauri A. Aaltonen,
The discovery of drivers of cancer has traditionally focused on protein-coding genes
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