Produção Nacional
Revisado por pares
Danilo Lopes Ferreira Lima, Sandro Dias Rocha Mendes Carneiro, Fladia Taciana de Sousa Barbosa, Maria Vieira de Lima Saintrain, Jean André Hervé Moizan, J. Doucet,
Objectives To assess salivary flow in older patients with type 2 diabetes mellitus (DM2) and its association with xerostomia. Methods Cross-sectional clinical study conducted with older patients diagnosed with type 2 diabetes for at least one year receiving treatment at the Integrated Center for Diabetes and Hypertension of Ceará (CIHD) in the city of Fortaleza, Ceará, Northeastern Brazil. Oral clinical examination was carried out to assess the decayed, missing and filled teeth index (DMFT). Perception ...
Tópico(s): Oral Health Pathology and Treatment
2017 - Public Library of Science | PLoS ONE
Tobias W. M. Keil, Daniel P. Feldmann, Gabriella Costabile, Qian Zhong, Sandro da Rocha, Olivia M. Merkel,
Localized aerosol delivery of gene therapies is a promising treatment of severe pulmonary diseases including lung cancer, cystic fibrosis, COPD and asthma. The administration of drugs by inhalation features multiple benefits including an enhanced patient acceptability and compliance. The application of a spray dried powder formulation has advantages over solutions due to their increased stability and shelf life. Furthermore, optimal sizes of the powder can be obtained by spray drying to allow a ...
Tópico(s): Aerosol Filtration and Electrostatic Precipitation
2019 - Elsevier BV | European Journal of Pharmaceutics and Biopharmaceutics
Produção Nacional
Revisado por pares
Alexandre R. Marra, Thiago Zinsly Sampaio Camargo, Vanessa Jonas Cardoso, Denis Faria Moura, Emerson Casemiro de Andrade, Juliana Wentzcovitch, Alex Sandro Santos da Rocha, Oscar Fernando Pavão dos Santos, Michael B. Edmond,
Background Hand hygiene (HH) compliance can be affected by the accessibility of products (alcohol-based products or chlorhexidine) and by the formulations of these products. There are few published studies comparing different alcohol-based hand disinfection formulations. Methods This study was conducted in a 41-bed medical-surgical intensive care unit at a private tertiary care hospital. Over a 16-week period, we assessed HH compliance by direct observation of practice using iPods and measurement ...
Tópico(s): Nosocomial Infections in ICU
2012 - Elsevier BV | American Journal of Infection Control
Sandro R. P. da Rocha, Keith P. Johnston,
Measurements of the interfacial tension γ at the water-CO2 interface with the surfactant perfluoropolyetherCOO-NH4+ (Mw = 2500) are utilized to determine the surfactant interfacial area, surface pressure vs area, critical microemulsion concentration, and the thermodynamic properties of microemulsion formation. The measurements were made at equilibrium vs surfactant concentration with a tandem variable-volume pendant drop tensiometer from 25 to 65 °C at a constant CO2 density of 0.842 g·mL-1. The experimental ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2000 - American Chemical Society | Langmuir
Petros A. Psathas, Sandro R. P. da Rocha, C. Ted Lee, Keith P. Johnston, Kwon Taek Lim, S. E. Webber,
The stability of water-in-CO2 (W/C) emulsions stabilized with poly(dimethylsiloxane)-b-poly(methacrylic acid) (PDMS-b-PMA) and PDMS-b-poly(acrylic acid) (PDMS-b-PAA) ionomer surfactants is reported as a function of surfactant architecture, pH, temperature, pressure, and droplet flocculation. For a given PDMS block length, the stability of the emulsion is correlated with the distance from the balanced state where the surfactant prefers the water and CO2 phases equally. When the pH starting at 3 is raised ...
Tópico(s): Polymer composites and self-healing
2000 - American Chemical Society | Industrial & Engineering Chemistry Research
Denise S. Conti, Daniel Brewer, Jordan Grashik, Sumant Avasarala, Sandro R. P. da Rocha,
Small interfering RNA (siRNA)-based therapies have great promise in the treatment of a number of prevalent pulmonary disorders including lung cancer, asthma and cystic fibrosis. However, progress in this area has been hindered due to the lack of carriers that can efficiently deliver siRNA to lung epithelial cells, and also due to challenges in developing oral inhalation (OI) formulations for the regional administration of siRNA and their carriers to the lungs. In this work we report the ability of ...
Tópico(s): Inhalation and Respiratory Drug Delivery
2014 - American Chemical Society | Molecular Pharmaceutics
Lin Yang, Sandro R. P. da Rocha,
Poly(amido amine) (PAMAM) dendrimers are promising nanocarriers in a wide range of biomedical applications including gene and drug delivery and as imaging agents. They have unique structural properties and are characterized by high size uniformity, low polydispersity, and a large number of modifiable surface groups. Drug-dendrimer systems are usually further modified through the conjugation of ligands in order to confer the carriers' specific characteristics designed to enhance their efficacy. The ...
Tópico(s): Polymer Surface Interaction Studies
2014 - American Chemical Society | Molecular Pharmaceutics
Produção Nacional
Revisado por pares
Marcos R. Guilherme, Marcos R. Maurício, Ernandes T. Tenório‐Neto, Marcos H. Kunita, Lúcio Cardozo‐Filho, Thelma S.P. Cellet, Guilherme M. Pereira, Edvani C. Muniz, Sandro R. P. da Rocha, Adley F. Rubira,
Well-defined polycaprolactone (PCL) nanoparticles loaded with progesterone (P4) were obtained by scCO2 antisolvent expansion of emulsions as a drying strategy. PCL nanoparticles with an average diameter of 82 nm were formed by the emulsification of an ethyl acetate–water mixture containing P4 and poly(vinyl alcohol) (PVA) as the stabilizing agent under ultrasonic irradiation. Emulsion particles were dried in scCO2 and the results were compared with drying at ambient conditions. The scCO2 expansion- ...
Tópico(s): Microencapsulation and Drying Processes
2014 - Elsevier BV | Materials Letters
Kanika Bhargava, Denise S. Conti, Sandro R. P. da Rocha, Yifan Zhang,
Although antimicrobial activities of plant essential oils are well documented, challenges remain as to their application in fresh produce due to the hydrophobic nature of essential oils. Oregano oil nanoemulsions were formulated with a food-grade emulsifier and evaluated for their efficacy in inactivating the growth of foodborne bacteria on fresh lettuce. Lettuce was artificially inoculated with Listeria monocytogenes, Salmonella Typhimurium and Escherichia coli O157:H7, followed by a one-minute ...
Tópico(s): Insect Pest Control Strategies
2014 - Elsevier BV | Food Microbiology
Produção Nacional
Revisado por pares
Balaji Bharatwaj, Abdul Khader Mohammad, Radovan Dimovski, Fernando Cássio, Reinaldo C. Bazito, Denise S. Conti, Qiang Fu, Joshua Reineke, Sandro R. P. da Rocha,
The purpose of this study was to determine the effect of PEGylation on the interaction of poly(amidoamine) (PAMAM) dendrimer nanocarriers (DNCs) with in vitro and in vivo models of the pulmonary epithelium. Generation-3 PAMAM dendrimers with varying surface densities of PEG 1000 Da were synthesized and characterized. The results revealed that the apical to basolateral transport of DNCs across polarized Calu-3 monolayers increases with an increase in PEG surface density. DNC having the greatest number ...
Tópico(s): Membrane Separation and Gas Transport
2014 - American Chemical Society | Molecular Pharmaceutics
Produção Nacional
Revisado por pares
Marta Giovanetti, Francesco Pinotti, Camila Zanluca, Vagner Fonseca, Taishi Nakase, Andrea Cristine Koishi, Marcel Kruchelski Tschá, Guilherme Marques Soares, Gisiane Gruber Dorl, Antônio Ernesto Meister Luz Marques, Renato Silva de Sousa, Talita Adelino, Joilson Xavier, Carla de Oliveira, Sandro Patroca, Natália Rocha Guimarães, Hegger Fritsch, Maria Angélica Mares-Guia, Flávia Mauad Levy, Pedro Henrique de Oliveira Passos, Vinicius Leme da Silva, Luiz Augusto Pereira, Ana Flávia Mendonça, Isabel Luana de Macêdo, Davi Emanuel Ribeiro de Sousa, Gabriela Rodrigues de Toledo Costa, Márcio Botelho de Castro, Miguel de Souza Andrade, Filipe Vieira Santos de Abreu, Fabrício Souza Campos, Felipe Campos de Melo Iani, Maira Alves Pereira, Karina Ribeiro Leite Jardim Cavalcante, André Ricardo Ribas Freitas, Carlos F. Campelo de Albuquerque, Eduardo Marques Macário, Marlei Pickler Debiasi dos Anjos, Rosane Campanher Ramos, Aline Alves Scarpellini Campos, Adriano Pintér, Márcia Chame, Lívia Abdalla, Irina Nastassja Riediger, Sérvio Pontes Ribeiro, Ana I. Bento, Túlio de Oliveira, Carla Freitas, Noely Fabiana Oliveira de Moura, Allison Fabri, Cintia Damasceno dos Santos Rodrigues, Carolina Cardoso dos Santos, Marco Antônio Barreto de Almeida, Edmilson dos Santos, Jáder da Cruz Cardoso, Douglas A. Augusto, Eduardo Krempser, Luís Filipe Mucci, R. Gatti, Sabrina Fernandes Cardoso, João Augusto Brancher Fuck, Maria Goretti David Lopes, Ivana Lúcia Belmonte, Gabriela Mayoral Pedroso da Silva, Maiane Regina Ferreira Soares, Marilia de Melo Santos de Castilhos, Joseana Cardoso de Souza e Silva, Alceu Bisetto, Emanuelle Gemin Pouzato, Laurina Setsuko Tanabe, Daniele Akemi Arita, Ricardo Matsuo, Josiane dos Santos Raymundo, Paula Cristina Linder Silva, Ana Santana Araújo Ferreira Silva, Sandra Samila, Glauco Carvalho, Rodrigo G. Stábeli, Wildo Navegantes, Luciano Andrade Moreira, Álvaro Ferreira, Guilherme Garcia Pinheiro, Bruno Tardelli Diniz Nunes, Daniele Barbosa de Almeida Medeiros, Ana Cecília Ribeiro Cruz, Rivaldo Venâncio da Cunha, Wesley C. Van Voorhis, Ana María Bispo de Filippis, María Almirón, Edward C. Holmes, Daniel Ramos, Alessandro Romano, José Lourenço, Luíz Carlos Júnior Alcântara, Claudia Nunes Duarte dos Santos,
Despite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil, our understanding of disease outbreaks is hampered by limited viral genomic data. Here, through a combination of phylogenetic and epidemiological models, we reconstructed the recent transmission history of YFV within different epidemic seasons in Brazil. A suitability index based on the highly domesticated Aedes aegypti was able to capture the seasonality of reported human infections. Spatial modeling ...
Tópico(s): Primate Behavior and Ecology
2023 - American Association for the Advancement of Science | Science Advances
Hanming Zhang, Rashed M. Almuqbil, Sulaiman S. Alhudaithi, Fatemah S. Sunbul, Sandro R. P. da Rocha,
Lung cancers remain the leading cause of cancer-related death in both men and women. Infiltrating immune cells in the tumor microenvironment (TME) play a critical role in the formation, progression, and the response of solid tumors to therapy, including in lung cancers. Clinical studies have established that tumor-associated macrophages (TAMs) and their phenotypical composition are critical immune infiltrates in the lung TME, with the abundance of the M2-like phenotype negatively correlating with ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2021 - Elsevier BV | International Journal of Pharmaceutics
Himali D. Jayathilake, J.A. Driscoll, Andrey N. Bordenyuk, Libo Wu, Sandro R. P. da Rocha, Cláudio N. Verani, Alexander V. Benderskii,
Molecular organization of Langmuir-Blodgett (LB) monolayers of novel copper-containing metal-ligand surfactants was characterized by the surface-selective vibrational sum frequency generation (SFG) spectroscopy. The orientational and conformational order inferred from the SFG peak amplitudes and line shapes were correlated with the two-dimensional phases of the monolayers observed in the compression isotherms. The octadecyl-pyridin-2-ylmethyl-amine (L(PyC18)) ligand by itself shows good amphiphilic ...
Tópico(s): Photosynthetic Processes and Mechanisms
2009 - American Chemical Society | Langmuir
Produção Nacional
Revisado por pares
Ana Paula Rômio, Cláudia Sayer, Pedro Henrique Hermes de Araújo, Mariam D. Al-Haydari, Libo Wu, Sandro R. P. da Rocha,
Abstract Nanocapsules (NCs) are promising candidates for the controlled and targeted delivery of therapeutics in a variety of biomedical applications. In this work we report the formation of NCs by miniemulsion polymerization with renewable, biodegradable, and biocompatible surfactant (lecithin) and hydrophobe (Neobee M5). PMMA was employed as the model (and biocompatible) polymer to synthesize the NCs. Stable dispersions of NCs with sizes between 200–500 nm in diameter and high encapsulation efficiencies ...
Tópico(s): Surfactants and Colloidal Systems
2009 - Wiley | Macromolecular Chemistry and Physics
Sandro R. P. da Rocha, Keith P. Johnston, Peter J. Rossky,
An important goal is the design of economically viable amphiphiles capable of forming and stabilizing water domains in bulk CO2. To enhance the understanding of this class of systems, we present in this work the results from atomistic molecular dynamics computer simulations of a perfluoropolyether ammonium carboxylate surfactant monolayer at the high-pressure CO2|water interface. The system is modeled including all internal degrees of freedom for the surfactant anion, and considering all atoms explicitly. ...
Tópico(s): Ionic liquids properties and applications
2002 - American Chemical Society | The Journal of Physical Chemistry B
Matthew T. Stone, Sandro R. P. da Rocha, Peter J. Rossky, Keith P. Johnston,
Fundamental molecular understanding of surfactants at the CO2/water interface is lacking, especially in the context of the poor performance of hydrocarbon-based surfactants relative to fluorocarbons. We present computer simulations of a dichain fluorinated phosphate surfactant known to promote microemulsion formation and its hydrocarbon analogue which does not. Analysis of the computer simulation results shows that CO2 solvates both tails well. In fact, at equal area per surfactant, CO2 penetrates ...
Tópico(s): Enhanced Oil Recovery Techniques
2003 - American Chemical Society | The Journal of Physical Chemistry B
Sandro R. P. da Rocha, Jasper L. Dickson, Dongman Cho, Peter J. Rossky, Keith P. Johnston,
Amphiphiles of a new class, with very short and bulky CO2-philic headgroups, the trisiloxane surfactants of the form ((CH3)3SiO)2Si(CH3)(CH2)3EOnR, where EO stands for ethylene oxide, are shown to be very interfacially active at the CO2−water interface, as indicated by their effectiveness in forming and stabilizing both concentrated and dilute emulsions of water and CO2. A transition in morphology from water-in-CO2 (W/C) to CO2-in-water (C/W) emulsions is induced by manipulating the surfactant hydrophilic- ...
Tópico(s): Enhanced Oil Recovery Techniques
2003 - American Chemical Society | Langmuir
Udayan Chokshi, Parthiban Selvam, Lionel Porcar, Sandro R. P. da Rocha,
In this work we use in situ high-pressure tensiometry to screen non-ionic ethoxylated surfactants at the 1,1,1,2,3,3,3-heptafluoropropane (HFA227) propellant|Water (HFA227|W) interface. The EOnPO∼30EOn series, where EO stands for ethylene oxide and PO for propylene oxide, and n the number of repeat EO units, was selected for this study based on the favorable interactions reported between HFA propellants and the PO moiety. The surfactants used in FDA-approved pressurized metered-dose inhaler formulations ...
Tópico(s): Surfactants and Colloidal Systems
2008 - Elsevier BV | International Journal of Pharmaceutics
S.S. Hindo, R. Shakya, N. S. Rannulu, M. ALLARD, Mary Jane Heeg, M. T. Rodgers, Sandro R. P. da Rocha, Cláudio N. Verani,
Hydrolysis of the asymmetric pyridine- and phenol-containing ligand HL1 (2-hydroxy-4-6-di-tert-butylbenzyl-2-pyridylmethyl)imine) led to the use of bis-(3,5-di-tert-butyl-2-phenolato-benzaldehyde)copper(II), [CuII(LSAL)2] (1) as a precursor for bis-(2,4-di-tert-butyl-6-octadecyliminomethyl-phenolato)copper(II), [CuII(L2)2] (3), bis-(2,4-di-tert-butyl-6-octadecyl aminomethyl-phenolato)copper(II), [CuII(L2A)2] (3′), and bis-(2,4-di-tert-butyl-6-[(3,4,5-tris-dodecyloxy-phenylimino)-methyl]-phenolato)copper( ...
Tópico(s): Magnetism in coordination complexes
2008 - American Chemical Society | Inorganic Chemistry
Robson P. S. Peguin, Sandro R. P. da Rocha,
Understanding solvation in hydrofluoroalkane (HFA) propellants is of great importance for the development of novel pressurized metered-dose inhaler (pMDI) formulations. HFA-based pMDIs are not only the most widely used inhalation therapy devices for delivering small drug molecules to the respiratory tract, but they also hold promise as vehicles for the delivery of therapeutic biomolecules to and through the lungs. In this work we use binding energy calculations to determine the degree of interaction ...
Tópico(s): Chemical Thermodynamics and Molecular Structure
2008 - American Chemical Society | The Journal of Physical Chemistry B
Robson P. S. Peguin, Ganesh Kamath, Jeffrey J. Potoff, Sandro R. P. da Rocha,
A new all-atom force field capable of accurately predicting the bulk and interfacial properties of 1,1,1,2-tetrafluoroethane (HFA134a) is reported. Parameterization of several force fields with different initial charge configurations from ab initio calculations was performed using the histogram reweighting method and Monte Carlo simulations in the grand canonical ensemble. The 12-6 Lennard-Jones well depth and diameter for the different HFA134a models were determined by fitting the simulation results ...
Tópico(s): Machine Learning in Materials Science
2008 - American Chemical Society | The Journal of Physical Chemistry B
J.A. Driscoll, M. ALLARD, Libo Wu, Mary Jane Heeg, Sandro R. P. da Rocha, Cláudio N. Verani,
Abstract Herein, we describe the synthesis and characterization of a novel series of single‐tail amphiphiles L (Py=pyridine, C n =C 18 , C 16 , C 14 , C 10 ) and their copper(II)‐containing complexes, which are of relevance for patterned films. The N‐ (pyridine‐2‐ylmethyl)alkyl‐1‐amine ligands and their complexes [Cu II Cl 2 (L )] ( 1 ), [Cu II Cl 2 (L )] ( 2 ), [Cu II Cl 2 (L )] ( 3 ), [Cu II Br 2 (L )] ( 4 ), [Cu II Br 2 (L )] ( 5 ), and [Cu II Br 2 (L )] ( 6 ) were synthesized, isolated, and characterized by means of mass spectrometry, IR and NMR spectroscopies, ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2008 - Wiley | Chemistry - A European Journal
Keith P. Johnston, Sandro R. P. da Rocha,
Tópico(s): Ionic liquids properties and applications
2008 - Elsevier BV | The Journal of Supercritical Fluids
Balaji Bharatwaj, Libo Wu, Judith A. Whittum‐Hudson, Sandro R. P. da Rocha,
Tópico(s): Advanced Drug Delivery Systems
2010 - Elsevier BV | Biomaterials
Libo Wu, Sandro R. P. da Rocha,
In this work we investigate the ability of biodegradable and biocompatible lactide-based nonionic amphiphiles to stabilize a model drug (salbutamol base) dispersion in hydrofluoroalkane (HFA) propellant. A series of triblock copolymers of the type poly(lactide)-poly(ethylene glycol)-poly(lactide) (LA(m)EO(n)LA(m)) with varying molecular weight (MW) and % EO were synthesized. The cohesive forces between drug particles in liquid HFA in the presence of the amphiphiles were quantitatively determined by colloidal ...
Tópico(s): Space Exploration and Technology
2007 - American Chemical Society | Langmuir
Libo Wu, Balaji Bharatwaj, Jayanth Panyam, Sandro R. P. da Rocha,
Tópico(s): Granular flow and fluidized beds
2007 - Springer Science+Business Media | Pharmaceutical Research
Libo Wu, Mariam D. Al-Haydari, Sandro R. P. da Rocha,
Challenges in reformulating pressurized metered-dose inhalers (pMDIs) with hydrofluoroalkane (HFA) propellants, and the potential of inhalation formulations for the delivery of drugs to and through the lungs have encouraged the development of novel suspension-based pMDI formulations. In this work we propose a new methodology for engineering polar drug particles with enhanced stability and aerosol characteristics in propellant HFAs. The approach consists in ‘trapping’ HFA-philic moieties at the surface ...
Tópico(s): Surfactants and Colloidal Systems
2007 - Elsevier BV | European Journal of Pharmaceutical Sciences
Libo Wu, Robson P. S. Peguin, Sandro R. P. da Rocha,
Understanding solvation in hydrofluoroalkane (HFA) propellants is of great importance for the development of novel pressurized metered-dose inhaler (pMDI) formulations. HFA-based pMDIs are not only the most widely used inhalation therapy devices for treating lung diseases, but they also hold promise as vehicles for the systemic delivery of biomolecules to and through the lungs. In this work we propose a combined microscopic experimental and computational approach to quantitatively relate the chemistry ...
Tópico(s): Force Microscopy Techniques and Applications
2007 - American Chemical Society | The Journal of Physical Chemistry B
R. Shakya, S.S. Hindo, Libo Wu, Suolong Ni, M. ALLARD, Mary Jane Heeg, Sandro R. P. da Rocha, G.T. Yee, Hrant P. Hratchian, Cláudio N. Verani,
A general approach toward amphiphilic systems bearing multimetallic clusters and their ability to form Langmuir-Blodgett films is presented. The synthetic strategy to stabilize these clusters involves the use of a ligand (HL) containing an N(2)O-donor set and long octadecanoic chains to obtain the carboxylate-supported [L(2)Cu(4)(mu(4)-O)(mu(2)-OAc)(4)]EtOH (1) and [L(2)Cu(4)(mu(4)-O)(mu(2)-OBz)(4)] (2) in which OAc(-) and OBz(-) represent acetate (1) and benzoate (2) co-ligands. These species were thoroughly ...
Tópico(s): Physics of Superconductivity and Magnetism
2007 - Wiley | Chemistry - A European Journal
R. Shakya, S.S. Hindo, Libo Wu, M. ALLARD, Mary Jane Heeg, Hrant P. Hratchian, Bruce R. McGarvey, Sandro R. P. da Rocha, Cláudio N. Verani,
The stabilization of a bivalent oxidation state in cobalt complexes of phenolate-based asymmetric tridentate ligands with iodo and bromo substituents is studied. The complexes [CoII(LIA)2].2CH3OH (1) and [CoII(LBrA)2].CH3OH (2) were characterized by means of several spectroscopic and spectrometric techniques. The molecular structure of 1 was determined by diffractometric analysis and reveals the cobalt(II) ion in a distorted-octahedral geometry. The centrosymmetric metal ion adopts a local D2h symmetry ...
Tópico(s): Magnetism in coordination complexes
2007 - American Chemical Society | Inorganic Chemistry