Jürg Fröhlich, Sandro Graffi, Simon Schwarz,
We present a new proof of the convergence of the N −particle Schrödinger dynamics for bosons towards the dynamics generated by the Hartree equation in the mean-field limit. For a restricted class of two-body interactions, we obtain convergence estimates uniform in $${\hbar}$$ , up to an exponentially small remainder. For $${\hbar = 0}$$ , the classical dynamics in the mean-field limit is given by the Vlasov equation.
Tópico(s): Quantum Mechanics and Applications
2007 - Springer Science+Business Media | Communications in Mathematical Physics
D. Mack, Sandro Belfanti, Urs Schwarz,
The study of eye movements has become popular in many fields of science. However, using the preprocessed output of an eye tracker without scrutiny can lead to low-quality or even erroneous data. For example, the sampling rate of the eye tracker influences saccadic peak velocity, while inadequate filters fail to suppress noise or introduce artifacts. Despite previously published guiding values, most filter choices still seem motivated by a trial-and-error approach, and a thorough analysis of filter ...
Tópico(s): Ophthalmology and Eye Disorders
2017 - Springer Science+Business Media | Behavior Research Methods
Guillem Casanovas, Dorine W. Swinkels, Sandro Altamura, Klaus Schwarz, Coby M. Laarakkers, Hans-Juergen Gross, Markus Wiesneth, H. Heimpel, Martina U. Muckenthaler,
Tópico(s): Erythrocyte Function and Pathophysiology
2011 - Springer Science+Business Media | Journal of Molecular Medicine
Sandro Sieber, Stefan Siegrist, Stéphanie Schwarz, Fabiola Porta, Susanne Schenk, Jörg Huwyler,
Enzyme immobilization is of high interest for industrial applications. However, immobilization may compromise enzyme activity or stability due to the harsh conditions which have to be applied. The authors therefore present a new and improved crosslinked layer-by-layer (cLbL) approach. Two different model enzymes (acid phosphatase and β-galactosidase) are immobilized under mild conditions on biocompatible, monodisperse, sub-micrometer poly(lactide-co-glycolide) (PLGA) particles. The resulting PLGA enzyme ...
Tópico(s): Nanoparticle-Based Drug Delivery
2017 - Wiley | Macromolecular Bioscience
Christian Meyer zu Natrup, Alina Tscherne, Christine Dahlke, Małgorzata Ciurkiewicz, Dai‐Lun Shin, Anahita Fathi, Cornelius Rohde, Georgia Kalodimou, Sandro Halwe, Leonard Limpinsel, Jan Hendrik Schwarz, Martha Klug, Meral Esen, Nicole Schneiderhan‐Marra, Alex Dulovic, Alexandra Kupke, Katrin Brosinski, Sabrina Clever, Lisa-Marie Schünemann, Georg Beythien, Federico Armando, Leonie Mayer, Leonie M. Weskamm, Sylvia Jany, Astrid Freudenstein, Tamara Tuchel, Wolfgang Baumgärtner, Peter G. Kremsner, Rolf Fendel, Marylyn M. Addo, Stephan Becker, Gerd Sutter, Asisa Volz,
The SARS-CoV-2 spike (S) glycoprotein is synthesized as a large precursor protein and must be activated by proteolytic cleavage into S1 and S2. A recombinant modified vaccinia virus Ankara (MVA) expressing native, full-length S protein (MVA-SARS-2-S) is currently under investigation as a candidate vaccine in phase I clinical studies. Initial results from immunogenicity monitoring revealed induction of S-specific antibodies binding to S2, but low-level antibody responses to the S1 domain. Follow-up ...
Tópico(s): Viral gastroenteritis research and epidemiology
2022 - American Society for Clinical Investigation | Journal of Clinical Investigation
Nikola Opačak, Sandro Dal Cin, Johannes Hillbrand, Benedikt Schwarz,
Optical nonlinearities are known to provide a coherent coupling between the amplitude and phase of the light, which can result in the formation of periodic waveforms. Lasers that emit such waveforms are referred to as optical frequency combs. Here we show that Bloch gain - a nonclassical phenomenon that was first predicted in the 1930s - plays an essential role in comb formation in quantum cascade lasers (QCLs). We develop a self-consistent theoretical model that considers all aspects of comb formation: ...
Tópico(s): Photonic and Optical Devices
2021 - American Physical Society | Physical Review Letters
Deniz Senyilmaz, Daniel Pfaff, Sam Virtue, Kathrin V. Schwarz, Thomas Fleming, Sandro Altamura, Martina U. Muckenthaler, Jürgen G. Okun, Antonio Vidal‐Puig, Peter P. Nawroth, Aurelio A. Teleman,
Abstract Since modern foods are unnaturally enriched in single metabolites, it is important to understand which metabolites are sensed by the human body and which are not. We previously showed that the fatty acid stearic acid (C18:0) signals via a dedicated pathway to regulate mitofusin activity and thereby mitochondrial morphology and function in cell culture. Whether this pathway is poised to sense changes in dietary intake of C18:0 in humans is not known. We show here that C18:0 ingestion rapidly ...
Tópico(s): Lipid metabolism and biosynthesis
2018 - Nature Portfolio | Nature Communications
Stefano Lorentini, Maurizio Amichetti, L. Spiazzi, Sandro Tonoli, Stefano Maria Magrini, F. Fellin, Marco Schwarz,
Tópico(s): Advanced Radiotherapy Techniques
2012 - Springer Science+Business Media | Strahlentherapie und Onkologie
Michael Bonadonna, Sandro Altamura, Elisabeth Tybl, Gaël Palais, Maria Qatato, Maria Polycarpou‐Schwarz, Martin Schneider, Christina Kalk, Wibke Rüdiger, Alina Ertl, Natasha S. Anstee, Ruzhica Bogeska, Dominic Helm, Michael D. Milsom, Bruno Galy,
Iron is mostly devoted to the hemoglobinization of erythrocytes for oxygen transport. However, emerging evidence points to a broader role for the metal in hematopoiesis, including the formation of the immune system. Iron availability in mammalian cells is controlled by iron-regulatory protein 1 (IRP1) and IRP2. We report that global disruption of both IRP1 and IRP2 in adult mice impairs neutrophil development and differentiation in the bone marrow, yielding immature neutrophils with abnormally high ...
Tópico(s): Iron Metabolism and Disorders
2022 - American Association for the Advancement of Science | Science Advances
Sandro Wolf, Jochen Reetz, Kathrin Hoffmann, Anne Gründel, Bernd-Andreas Schwarz, Ingrid Hänel, Peter Otto,
Tópico(s): Viral Infections and Immunology Research
2012 - Springer Science+Business Media | Archives of Virology
Produção Nacional
Maria Ligia Souza Silva, Juliano Tadeu Vilela de Resende, Anderson Ricardo Trevizam, Alex Sandro Torre Figueiredo, Kélin Schwarz,
In Brazil, the culture of strawberries is an important activity for small and medium farmers. Among the important factors for culture is fertilization, which can interfere in production and fruit quality. Silicon (Si) is one of the little studied in fertilization, which demonstrated some beneficial to several different cultures. The objective of this study was to evaluate the influence of Si on production and concentration of anthocyanin and titratable acid in the fruit and reading SPAD (chlorophyll) ...
Tópico(s): Growth and nutrition in plants
2013 - UNIVERSIDADE ESTADUAL DE LONDRINA | Semina Ciências Agrárias
Nikola Opačak, Florian Pilat, Dmitry Kazakov, Sandro Dal Cin, Georg Ramer, Bernhard Lendl, Federico Capasso, Benedikt Schwarz,
The linewidth enhancement factor (LEF) has recently moved into the spotlight of research on frequency comb generation in semiconductor lasers. Here we present a novel modulation experiment that enables direct measurement of the spectrally resolved LEF in a laser frequency comb. By utilizing a phase-sensitive technique, we are able to extract the LEF for each individual comb mode in any laser type. We first investigate and verify this universally applicable technique using Maxwell–Bloch simulations. ...
Tópico(s): Spectroscopy and Laser Applications
2021 - Optica Publishing Group | Optica
Sebastian Schwarz, Hannes Grillenberger, Stephan Tremmel, Sandro Wartzack,
Cage instability or highly dynamic cage movement can have a strong influence on the performance of rolling bearings. In addition to very loud and disturbing noises ("squeal"), bearing failure due to cage fracture can occur.This article deals with two topics: the general classification of cage motions and the prediction of application-dependent cage motions to prevent cage instability during operation. The dependencies of the unstable cage movement on the bearing's load and geometric characteristics ...
Tópico(s): Lubricants and Their Additives
2021 - Taylor & Francis | Tribology Transactions
Peter Macheroux, Oliver Seth, Claus Bollschweiler, Margarete Schwarz, Manfred Kurfürst, Lo‐Chun Au, Sandro Ghisla,
Here we report the cDNA-deduced amino-acid sequence of L-amino-acid oxidase (LAAO) from the Malayan pit viper Calloselasma rhodostoma, which shows 83% identity to LAAOs from the Eastern and Western diamondback rattlesnake (Crotalus adamanteus and Crotalus atrox, respectively). Phylogenetic comparison of the FAD-dependent ophidian LAAOs to FAD-dependent oxidases such as monoamine oxidases, D-amino-acid oxidases and tryptophan 2-monooxygenases reveals only distant relationships. Nevertheless, all LAAOs ...
Tópico(s): Cellular transport and secretion
2001 - Wiley | European Journal of Biochemistry
Johannes Hillbrand, Léonard M. Krüger, Sandro Dal Cin, Hedwig Knötig, Jonas Heidrich, A. M. Andrews, G. Strasser, U. Keller, Benedikt Schwarz,
Quantum cascade detectors (QCD) are photovoltaic mid-infrared detectors based on intersubband transitions. Owing to the sub-picosecond carrier transport between subbands and the absence of a bias voltage, QCDs are ideally suited for high-speed and room temperature operation. Here, we demonstrate the design, fabrication, and characterization of 4.3 µm wavelength QCDs optimized for large electrical bandwidth. The detector signal is extracted via a tapered coplanar waveguide (CPW), which was impedance- ...
Tópico(s): Photonic and Optical Devices
2021 - Optica Publishing Group | Optics Express
Anna Villa, Sandro Santagata, Fabio Bozzi, Silvia Giliani, Annalisa Frattini, Luisa Imberti, Luisa Benerini Gatta, Hans D. Ochs, Klaus Schwarz, Luigi D. Notarangelo, Paolo Vezzoni, Eugenia Spanopoulou,
Genomic rearrangement of the antigen receptor loci is initiated by the two lymphoid-specific proteins Rag-1 and Rag-2. Null mutations in either of the two proteins abrogate initiation of V(D)J recombination and cause severe combined immunodeficiency with complete absence of mature B and T lymphocytes. We report here that patients with Omenn syndrome, a severe immunodeficiency characterized by the presence of activated, anergic, oligoclonal T cells, hypereosinophilia, and high IgE levels, bear missense ...
Tópico(s): T-cell and B-cell Immunology
1998 - Cell Press | Cell
Produção Nacional
Revisado por pares
Nellie Georgiou‐Karistianis, Louise A. Corben, Kathrin Reetz, Isaac Adanyeguh, Manuela Corti, Dinesh K. Deelchand, Martin B. Delatycki, Imis Dogan, Rebecca Evans, Jennifer Farmer, Marcondes C. França, William Gaetz, Ian H. Harding, Karen S. Harris, Steven M. Hersch, Richard Joules, James M. Joers, Michelle L. Krishnan, Michelle Lax, Eric F. Lock, David T. Lynch, Thomas H. Mareci, Sahan Muthuhetti Gamage, Massimo Pandolfo, Marina Papoutsi, Thiago Junqueira Ribeiro de Rezende, Timothy P. L. Roberts, Jens T. Rosenberg, Sandro Romanzetti, Jörg B. Schulz, Traci Schilling, Adam J. Schwarz, S. H. Subramony, Bert Yao, Stephen Zicha, Christophe Lenglet, Pierre‐Gilles Henry,
Introduction Drug development for neurodegenerative diseases such as Friedreich’s ataxia (FRDA) is limited by a lack of validated, sensitive biomarkers of pharmacodynamic response in affected tissue and disease progression. Studies employing neuroimaging measures to track FRDA have thus far been limited by their small sample sizes and limited follow up. TRACK-FA, a longitudinal, multi-site, and multi-modal neuroimaging natural history study, aims to address these shortcomings by enabling better understanding ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2022 - Public Library of Science | PLoS ONE
Anke Weber, Martina Grünhagen, Willem Hovestreydt, Saskia Nehls, Lutz Popko, Sandro Schwarz, Simon Thuault, Thomas Warscheid,
The 2021 fieldwork of The Ramesses III (KV 11) Publication and Conservation Project1 included the excavation of room H, the first upper layer of room I, the area behind pillars 1 to 7 in hall J (fol. aisle), and room Ja. Furthermore, consolidation work on pillars and the ceiling in the burial chamber began, and initial work for future conservation was carried out. Microbiological examination of the entire tomb took place to gain data for health precautions and in support of conservation. Finally, our ...
Tópico(s): Ancient Egypt and Archaeology
2023 - American Research Center in Egypt | Journal of the American Research Center in Egypt
Anke Weber, Klara Dietze, Lutz Popko, Gareth Rees, Sandro Schwarz,
The following article presents preliminary results of a sondage in the burial chamber (hall J) and a visual survey in the areas H, I, J, Ja-Jd, K1, K2, and L during the 2019/2020 field season carried out by The Ramesses III (KV 11) Publication and Conservation Project in the tomb of pharaoh Ramesses III.1 The detailed description and interpretation of the initial excavation work were omitted from the Second Report2 because it required more extensive discussion. The authors present their archaeological ...
Tópico(s): Archaeological Research and Protection
2022 - American Research Center in Egypt | Journal of the American Research Center in Egypt
Produção Nacional
Revisado por pares
Alex Sandro Torre Figueiredo, Juliano Tadeu Vilela de Resende, Kélin Schwarz, Josué Clock Marodin, Alexandre Gonçalves Galvão, Nathalia Campos Vilela Resende,
ABSTRACT Tomato is the most important vegetable species and has a strong bottleneck effect in its domestication and evolution. In exploring the existing genetic variability in commercial germplasm, germplasm has been proven to be an excellent alternative to obtain inbred lines in order to provide superior new hybrids in the future. In this sense, the objective of this study was to estimate the genetic distance among commercial processing tomato hybrids via agronomical and quality postharvest fruit ...
Tópico(s): Silkworms and Sericulture Research
2017 - UNIVERSIDADE FEDERAL DE LAVRAS | Ciência e Agrotecnologia
Peter Macheroux, Oliver Seth, Claus Bollschweiler, Margarete Schwarz, Manfred Kurfürst, Lo‐Chun Au, Sandro Ghisla,
Here we report the cDNA-deduced amino-acid sequence of l-amino-acid oxidase (LAAO) from the Malayan pit viper Calloselasma rhodostoma, which shows 83% identity to LAAOs from the Eastern and Western diamondback rattlesnake (Crotalus adamanteus and Crotalus atrox, respectively).Phylogenetic comparison of the FADdependent ophidian LAAOs to FAD-dependent oxidases such as monoamine oxidases, d-amino-acid oxidases and tryptophan 2-monooxygenases reveals only distant relationships.Nevertheless, all LAAOs ...
Tópico(s): Aquaculture Nutrition and Growth
2001 - Wiley | European Journal of Biochemistry
Produção Nacional
Revisado por pares
Alex Sandro Torre Figueiredo, Juliano Tadeu Vilela de Resende, Marcos Ventura Faria, Juliana Tauffer de Paula, Kélin Schwarz, Daniel Suek Zanin,
The objective was to estimate the combining ability of lines and heterosis in industrial tomato genotypes for the identification of those with good potential for breeding programs. Ten lines of industrial tomato, 45 hybrids derived from a complete diallel and two commercial check cultivars were evaluated. The combining ability of tomato lines and heterosis of hybrid combinations for fruit-quality related traits were estimated. Non-additive effects predominated in the genetic control of all traits. ...
Tópico(s): Silkworms and Sericulture Research
2015 - Brazilian Society of Plant Breeding | Crop Breeding and Applied Biotechnology
Sandro Tonoli, Paola Vitali, Vieri Scotti, Filippo Bertoni, L. Spiazzi, B. Ghedi, F. Banci Buonamici, L. Marrazzo, G. Guidi, Icro Meattini, P. Bastiani, Maurizio Amichetti, Marco Schwarz, Stefano Maria Magrini,
Tópico(s): Pleural and Pulmonary Diseases
2011 - Elsevier BV | Radiotherapy and Oncology
Anna Villa, Cristina Sobacchi, L. D. Notarangelo, Fabio Bozzi, Mario Abinun, Tore G. Abrahamsen, Peter D. Arkwright, Michal Baniyash, Edward G. Brooks, Mary Ellen Conley, Patricia Cortés, Marzia Duse, Anders Fasth, Alexandra M. Filipovich, Anthony J. Infante, Alison Jones, Evelina Mazzolari, Susanna Müller, Srdjan Pašić, Gideon Rechavi, Maria Grazia Sacco, Sandro Santagata, Marlis L. Schroeder, Reinhard Seger, Dario Strina, Alberto G. Ugazio, Jouni Väliaho, Mauno Vihinen, Larry B. Vogler, Hans D. Ochs, Paolo Vezzoni, Wilhelm Friedrich, Klaus Schwarz,
Severe combined immunodeficiency (SCID) comprises a heterogeneous group of primary immunodeficiencies, a proportion of which are due to mutations in either of the 2 recombination activating genes (RAG)-1 and -2, which mediate the process of V(D)J recombination leading to the assembly of antigen receptor genes. It is reported here that the clinical and immunologic phenotypes of patients bearing mutations in RAGs are more diverse than previously thought and that this variability is related, in part, ...
Tópico(s): T-cell and B-cell Immunology
2001 - Elsevier BV | Blood
Adilson Anacleto, Suelena Cristina Moro, Luiz Antonio Michaliszyn Filho, Karina Capete, Sandro Deretti, José Ronaldo Mendonça Fassheber, Kátia Kalko Schwarz,
The oyster cultivation in Brazil has a great productive concentration in the Southern region of Brazil, however the consolidation of these productive arrangements occurs slowly and with great variation among the producing communities. Scattered information was found on the reasons for the uneven development of smaller arrangements. Therefore, in view of the relevance of the activity and in order to identify the factors responsible for the inequality in the growth of productive arrangements, a descriptive ...
Tópico(s): Innovation and Socioeconomic Development
2023 - Servicios Academicos Intercontinentales | Contribuciones a las Ciencias Sociales
David C. Schöndorf, Massimo Aureli, Fiona E. McAllister, Christopher J. Hindley, Florian Mayer, Benjamin Schmid, S. Pablo Sardi, Manuela Valsecchi, Susanna A. Hoffmann, Lukas Schwarz, Ulrike B. S. Hedrich, Daniela Berg, Lamya S. Shihabuddin, Jing Hu, Jan Pruszak, Steven P. Gygi, Sandro Sonnino, Thomas Gasser, Michela Deleidi,
Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal storage disorder Gaucher's disease (GD), are the strongest genetic risk factor for Parkinson's disease (PD) known to date. Here we generate induced pluripotent stem cells from subjects with GD and PD harbouring GBA1 mutations, and differentiate them into midbrain dopaminergic neurons followed by enrichment using fluorescence-activated cell sorting. Neurons show a reduction in glucocerebrosidase activity and protein ...
Tópico(s): Autophagy in Disease and Therapy
2014 - Nature Portfolio | Nature Communications
Sebastian Schwarz, Hannes Grillenberger, Stephan Tremmel, Sandro Wartzack,
Abstract The dynamic behavior of a cage can have a significant influence on the performance and the noise of a rolling bearing. In case of an unstable or high-frequency cage movement, vibrations are transmitted to the adjacent machine elements and the environment, which can influence the operating behavior of the whole system. In addition, a loud noise can often be perceived, which is referred to in the literature as cage rattling or squealing. In this paper, characteristics of different cage movements ...
Tópico(s): Mechanical Engineering and Vibrations Research
2021 - IOP Publishing | IOP Conference Series Materials Science and Engineering
Alina Tscherne, Jan Hendrik Schwarz, Cornelius Rohde, Alexandra Kupke, Georgia Kalodimou, Leonard Limpinsel, Nisreen M.A. Okba, Berislav Bošnjak, Inga Sandrock, Ivan Odak, Sandro Halwe, Lucie Sauerhering, Katrin Brosinski, Liangliang Nan, Elke R. Duell, Sylvia Jany, Astrid Freudenstein, Jörg Schmidt, Anke Werner, Michelle Gellhorn Serra, Michael Klüver, Wolfgang Guggemos, Michael Seilmaier, Clemens‐Martin Wendtner, Reinhold Förster, Bart L. Haagmans, Stephan Becker, Gerd Sutter, Asisa Volz,
Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) has emerged as the infectious agent causing the pandemic coronavirus disease 2019 (COVID-19) with dramatic consequences for global human health and economics. Previously, we reached clinical evaluation with our vector vaccine based on modified vaccinia virus Ankara (MVA) against the Middle East respiratory syndrome coronavirus (MERS-CoV), which causes an infection in humans similar to SARS and COVID-19. Here, we describe the construction ...
Tópico(s): Viral Infections and Outbreaks Research
2021 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Sebastian Schwarz, Hannes Grillenberger, Oliver Graf-Goller, Marcel Bartz, Stephan Tremmel, Sandro Wartzack,
Rolling bearings have to meet the highest requirements in terms of guidance accuracy, energy efficiency, and dynamics. An important factor influencing these performance criteria is the cage, which has different effects on the bearing dynamics depending on the cage’s geometry and bearing load. Dynamics simulations can be used to calculate cage dynamics, which exhibit high agreement with the real cage motion, but are time-consuming and complex. In this paper, machine learning algorithms were used ...
Tópico(s): Adhesion, Friction, and Surface Interactions
2022 - Multidisciplinary Digital Publishing Institute | Lubricants
Corinne Vandermeulen, Isabel Leroux–Roels, James Vandeleur, Tommaso Staniscia, Ginette Girard, Murdo Ferguson, Giancarlo Icardi, Tino F. Schwarz, A. Munro Neville, Terry Nolan, Sandro Cinquetti, Tauseefullah Akhund, Sofie Van Huyneghem, Marianna Aggravi, Barry Kunnel, Bertrand de Wergifosse, Gabriele Filippo Di Domenico, Marco Costantini, Puneet Vir Singh, Elena Fragapane, Maria Lattanzi, Michele Pellegrini,
The currently licensed quadrivalent MenACWY-CRM conjugate vaccine presentation consists of two vials (lyophilised MenA and liquid MenCWY) to be reconstituted before injection. A new fully liquid formulation in a single vial has been developed to further improve the vaccine presentation. Since the MenA structure is subject to hydrolytic degradation, this study was conducted to compare the immunogenicity and safety of the investigational MenACWY-CRM liquid vaccine with the licensed vaccine. In this ...
Tópico(s): Pneumonia and Respiratory Infections
2021 - Elsevier BV | Vaccine