Ana Santos Cravo, Edward Carter, Mert Erkan, Emma Harvey, Makoto Furutani‐Seiki, Randall J. Mrsny,
External adherens junction-based cell-cell contacts involving E-cadherin interactions function to sense planar cell status and modulate epithelial cell proliferation through Hippo (Hpo) and non-canonical Wnt pathways signaling. We hypothesized these regulatory processes should also be sensitive to a similar cell-cell contact sensor associated with apical-basal polarity events at epithelial surfaces. We used 2 human pancreatic cancer cell lines to explore this hypothesis: one with the capacity to ...
Tópico(s): Axon Guidance and Neuronal Signaling
2015 - Taylor & Francis | Tissue Barriers
Ana Santos Cravo, Jim Bush, Girish Sharma, Rebecca Savioz, Claire Martin, Simon Craige, Tanvir Walele,
A randomised, parallel group clinical study was performed to evaluate the safety profile of an e-vapour product (EVP; 2.0% nicotine) in smokers of conventional cigarettes (CCs) switching to use the EVP for 12 weeks. During the study, no clinically significant product-related findings were observed in terms of vital signs, electrocardiogram, lung function tests and standard clinical laboratory parameters. Adverse events (AEs) reported by EVP subjects were more frequent during the first week after switching ...
Tópico(s): Respiratory and Cough-Related Research
2016 - Elsevier BV | Regulatory Toxicology and Pharmacology
Inês Martins, Valentina Costa, Filipe M. Porteiro, Alexandra Cravo, Ricardo S. Santos,
Mercury determinations were carried out in mussels ( Bathymodiolus azoricus ) from three Mid-Atlantic Ridge hydrothermal vents (Lucky Strike, Menez Gwen and Rainbow) and shrimps ( Rimicaris exoculata and Mirocaris fortunata ) from Rainbow. Among the three hydrothermal vents, mussels of Menez Gwen show the highest levels of total Hg and comparing mussels and shrimps from Rainbow the former show more Hg than shrimps. Mussels from different hydrothermal vents are exposed to different kinds of environment which ...
Tópico(s): Mercury impact and mitigation studies
2001 - Cambridge University Press | Journal of the Marine Biological Association of the United Kingdom
Produção Nacional
Revisado por pares
André M. Cravo, Karin Moreira Santos, Marcelo Bussotti Reyes, Marcelo S. Caetano, Peter Claessens,
The detection of causality is essential for our understanding of whether distinct events relate. A central requirement for the sensation of causality is temporal contiguity: As the interval between events increases, causality ratings decrease; for intervals longer than approximately 100 msec, the events start to appear independent. It has been suggested that this effect might be due to perception relying on discrete processing. According to this view, two events may be judged as sequential or simultaneous ...
Tópico(s): Neural and Behavioral Psychology Studies
2015 - The MIT Press | Journal of Cognitive Neuroscience
Produção Nacional
Revisado por pares
Patrícia Brasil, Mariano Zalis, Anielle de Pina-Costa, André M. Siqueira, Cesare Bianco Júnior, Sidnei Silva, André Luiz Lisboa Areas, Marcelo Pelajo‐Machado, Denise Anete Madureira de Alvarenga, Ana Carolina Faria da Silva Santelli, Hermano Gomes Albuquerque, Pedro Cravo, Filipe Vieira Santos de Abreu, Cassio Peterka, Graziela Maria Zaniní, Martha Cecília Suárez-Mútis, Alcides Pissinatti, Ricardo Lourenço‐de‐Oliveira, Cristiana Ferreira Alves de Brito, Maria de Fátima Ferreira‐da‐Cruz, Richard Culleton, Cláudio Tadeu Daniel‐Ribeiro,
Malaria was eliminated from southern and southeastern Brazil over 50 years ago. However, an increasing number of autochthonous episodes attributed to Plasmodium vivax have recently been reported from the Atlantic Forest region of Rio de Janeiro state. As the P vivax-like non-human primate malaria parasite species Plasmodium simium is locally enzootic, we performed a molecular epidemiological investigation to determine whether zoonotic malaria transmission is occurring.We examined blood samples from ...
Tópico(s): Parasite Biology and Host Interactions
2017 - Elsevier BV | The Lancet Global Health
Sónia Fernandes, Vasco Coelho Macias, Mariana Cravo, Cristina Amaro, Raquel Santos, Jorge Cardoso,
... for more papers by this authorMariana Cravo, Mariana Cravo Department of Dermatology, IPOLFG—Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, PortugalSearch for more papers by this authorCristina Amaro, Cristina Amaro Department of Dermatology and Venereology, Hospital Curry Cabral, Lisbon, PortugalSearch for more papers by this authorRaquel Santos, Raquel Santos Department of Dermatology and Venereology, Hospital ... for more papers by this authorMariana Cravo, Mariana Cravo Department of Dermatology, IPOLFG—Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, PortugalSearch for more papers by this authorCristina Amaro, Cristina Amaro Department of Dermatology and Venereology, Hospital Curry Cabral, Lisbon, PortugalSearch for more papers by this authorRaquel Santos, Raquel Santos Department of Dermatology and Venereology, Hospital ...
Tópico(s): Pesticide Exposure and Toxicity
2012 - Wiley | Contact Dermatitis
Produção Nacional
Revisado por pares
Angélica Simone Cravo Pereira, Marcos Veiga dos Santos, Gabriela Aferri, Rosana Rüegger Pereira da Silva Corte, Saulo da Luz e Silva, José Esler de Freitas Júnior, Paulo Roberto Leme, Francisco Palma Rennó,
The objective of this study was to evaluate the effect of lipid and selenium sources in diets for finishing Nellore steers on the fatty acid composition and selenium concentration of the longissimus muscle. Fifty Nellore steers (body weight = 458±39 kg) were assigned to one of six dietary treatments: 1) diet containing sunflower seed and inorganic selenium; 2) sunflower seed and organic selenium; 3) whole cottonseed and inorganic selenium; 4) whole cottonseed and organic selenium; 5) soybeans and inorganic ...
Tópico(s): Animal Nutrition and Physiology
2012 - Sociedade Brasileira de Zootecnia | Revista Brasileira de Zootecnia
Produção Nacional
Monique Helen Cravo Soares Farias, Norma Ely Santos Beltrão, Yvens Ely Martins Cordeiro, Cleber Assis dos Santos,
In recent years, it is possible to realize a change in the profile of deforestation in the Amazon, reflecting increasing rates of “little deforestations”, result from the diversification of productive activities related to family farming. In the Amazon, the state of Pará stands out for its strategic location when considering the Arc of Deforestation in advance, and also for its contribution in the distribution of lands by the Agrarian Reform, whose settlements add 1.055 units and 221.04 families ...
Tópico(s): Economic and Environmental Valuation
2018 - UNIVERSIDADE FEDERAL DO CEARÁ | Mercator
Produção Nacional
Revisado por pares
Keyth Daiann Felix Palmeira, Ana Paula Pereira de Oliveira Silva, José Atalvanio da Silva, Claudimary Bispo dos Santos,
... dos seguintes materiais: boldo-do-chile, hortelã, babosa, cravo, canela, alho, gengibre e capim-santo, adicionados a 150mL de água destilada em cada ...
Tópico(s): Insect Pest Control Strategies
2020 - UNIVERSIDADE ESTADUAL DE ALAGOAS | Diversitas Journal
Andreia Penado, J.T. Smit, A. M. Franquinho Aguiar, Délia Cravo, Carla Rêgo, Renata Santos, Mário Boieiro,
A checklist of the tephritid fauna (Diptera: Tephritidae) from Madeira archipelago is presented, including 17 known species and new distribution records for Porto Santo and Desertas Islands. An identification key to Madeira Tephritidae species with detailed illustrations is also provided. A new species of Oedosphenella Frey 1936, discovered in Madeira Island in 2004, is described as Oedosphenella bob sp. n. This genus is redefined and a key to the known species is provided. Comparative morphological ...
Tópico(s): Plant and animal studies
2020 - Q15088586 | Zootaxa
Produção Nacional
Revisado por pares
André Costa da Silva, Nilza de Lima Pereira Sales, Alisson Vinícius de Araújo, Cecílio Frois Caldeira Júnior,
... de vargem, goiaba vermelha (Psidium guajava), lippia, capim santo, goiaba branca, alfavaca cravo; manipueira de (Manihot esculenta). Também foram testados esses ...
Tópico(s): Plant tissue culture and regeneration
2009 - UNIVERSIDADE FEDERAL DE LAVRAS | Ciência e Agrotecnologia
Produção Nacional
Revisado por pares
Francesca Guaracyaba Garcia Chapadense, Éverton K. K. Fernandes, José Bento Pereira Lima, Ademir Jesus Martins, Luana Carrara Da Silva, Welington Tristão da Rocha, Adelair Helena dos Santos, Pedro Cravo,
INTRODUCTION: The mosquito Aedes aegypti has evolved resistance to pyrethroid insecticides. The present study evaluated Ae. aegypti from Goiânia for the resistant phenotype and for mutations associated with resistance. METHODS: Insecticide dose-response bioassays were conducted on mosquitoes descended from field-collected eggs, and polymerase chain reaction (PCR) was used to genotype 90 individuals at sites implicated in pyrethroid resistance. RESULTS: All mosquito populations displayed high levels ...
Tópico(s): Malaria Research and Control
2015 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Ana Teresa Barata, Carla Adriana Santos, Marília Cravo, Maria do Céu Vinhas, Catarina Morais, Elisabete Carolino, Lino Mendes, Jorge Roldão Vieira, Jorge Fonseca,
Undernutrition is frequently associated with advanced lung cancer. Accurate nutritional assessment tools are important to provide the proper nutritional therapy. Handgrip dynamometry has already been used in these patients, and the findings suggest that it is a good indicator of nutritional status.The aim of this study was to evaluate the association between nutritional status and handgrip strength (HGS) in patients with nonresectable lung cancer.Cross-sectional study involving thirty-seven subjects ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2016 - Routledge | Nutrition and Cancer
Alexandre Oliveira Ferreira, Joana Torres, E. Barjas, Joana Nunes, L Glória, Rosa Ferreira, Manuel Coelho da Rocha, Sónia Pereira, Sofia Dias, Antonio Santos, Marília Cravo,
Background and study aims: Propofol provides the best sedation in colonoscopy. The safety of non-anesthesiologist administration of propofol (NAAP) is still a matter of debate. The aim of the current study was to evaluate sedation safety, colonoscopy quality, and patient satisfaction with NAAP. Patients and methods: The study was a single-blinded, noninferiority, randomized controlled trial comparing NAAP (Group A) with anesthesiologist-administered sedation (Group B) performed at a single academic institution. ...
Tópico(s): Anesthesia and Sedative Agents
2016 - Thieme Medical Publishers (Germany) | Endoscopy
Produção Nacional
Revisado por pares
André M. Cravo, Gustavo Rohenkohl, Karin Moreira Santos, Anna C. Nobre,
The fundamental role that our long-term memories play in guiding perception is increasingly recognized, but the functional and neural mechanisms are just beginning to be explored. Although experimental approaches are being developed to investigate the influence of long-term memories on perception, these remain mostly static and neglect their temporal and dynamic nature. Here, we show that our long-term memories can guide attention proactively and dynamically based on learned temporal associations. ...
Tópico(s): Olfactory and Sensory Function Studies
2017 - The MIT Press | Journal of Cognitive Neuroscience
Marília Cravo, Catarina Sousa Guerreiro, Paula Moura Santos, Miguel Brito, Paula Ferreira, Catarina Fidalgo, Lourdes Tavares, António Dias Pereira,
The aim was to evaluate the presence of metabolic bone disease (MBD) in patients with Crohn's disease (CD) and to identify potential etiologic factors.The case-control study included 99 patients with CD and 56 controls with a similar age and gender distribution. Both groups had dual-energy x-ray absorptionmetry and a nutritional evaluation. Single nucleotide polymorphisms at the IL1, TNF-α, LTα, and IL-6 genes were analyzed in patients only. Statistical analysis was performed using SPSS software.The ...
Tópico(s): Microscopic Colitis
2010 - Oxford University Press | Inflammatory Bowel Diseases
Produção Nacional
Revisado por pares
Mário André Trindade Dantas, Camila Bernardes, Lidiane Asevedo, Thaís Rabito Pansani, Lucas de Melo França, Wilcilene Santos de Aragão, Franciely da Silva Santos, Elisa Cravo, Celso Lira Ximenes,
The palaeoecology of megamammals has been commonly accessed by stable isotope. Particularly in the Americas, this approach has been focusing efforts on the study of intertropical species, especially from a key paleozoogeographical region in the Late Quaternary of South America: the Brazilian Intertropical Region (BIR). Here we present an isotopic study (δ13C) conducted on bioapatite samples of Smilodon populator, Protocyon troglodytes and Arctotherium wingei from the BIR. We discuss their potential ...
Tópico(s): Primate Behavior and Ecology
2021 - Taylor & Francis | Historical Biology
Marta Rodrigues, Alexandra Cravo, P. Freire, Alexandra Rosa, D. Santos,
Tópico(s): Marine Biology and Ecology Research
2020 - Elsevier BV | Marine Chemistry
Produção Nacional
Revisado por pares
Fernanda Eduarda das Neves Martins, Jannifer Oliveira Chiang, Bruno Tardelli Diniz Nunes, B. Ribeiro, Livia Carício Martins, Lívia Medeiros Neves Casseb, Daniele Freitas Henriques, Consuelo Silva de Oliveira, Ethel Leonor Nóia Maciel, Rui Azevedo, Layna de Cássia Campos Cravo, Anne Jaquelyne Roque Barrêto, André Luiz Santos Pessoa, Arnaldo Jorge Martins Filho, Jorge Rodrigues de Sousa, Lavínia Schüler‐Faccini, Juarez Antônio Simões Quaresma, Pedro Fernando da Costa Vasconcelos, Raimunda do Socorro da Silva Azevedo,
Oropouche fever, an orthobunyavirus disease endemic in Brazilian Amazon, has caused many febrile epidemics. In 2024, an epidemic of Oropouche fever spread in Brazil, with more than 7930 cases reported between Jan 1 and Aug 31. Infections in pregnant people have suggested the possibility of negative fetal consequences, therefore we tested newborns with microcephaly for known congenital pathogens and Oropouche virus (OROV).
Tópico(s): Mosquito-borne diseases and control
2024 - Elsevier BV | The Lancet Infectious Diseases
Salvatore Febbraro, Tim Shea, Ana Santos Cravo,
Abstract Antihistamines have been in clinical use for more than 70 years to treat allergic and nonallergic symptoms including relief from cold and flu symptoms. Despite their widespread use, pharmacokinetic (PK) data are sparse for older, first‐generation antihistamines. This phase 1 single‐center open‐label, randomized, single‐dose, 3‐way crossover trial evaluated the PK profiles of 2 doses of film‐coated triprolidine caplets (2.5 and 5 mg) compared with a reference combination tablet (triprolidine ...
Tópico(s): Food Allergy and Anaphylaxis Research
2020 - Wiley | Clinical Pharmacology in Drug Development
Carlos Nobre‐Leitão, Pedro Lage, Marília Cravo, José Cabeçadas, Paula Chaves, A Alberto-Santos, João Correia, Janine Soares, F. Costa-Mira,
Objective: Previous studies have demonstrated a link betweenHelicobacter pyloriinfection and low grade B-cell gastric MALT lymphoma. The aim of this study was to evaluate the effect ofHelicobacter pylorieradication in 17 patients with low grade B-cell gastric MALT lymphoma stage EI. Methods: For disease staging EUS and CT scan were systematically performed. Eight patients were excluded from the present series because stage EII disease was diagnosed. To demonstrate B-cell monoclonality, immunohistochemistry ...
Tópico(s): Lymphoma Diagnosis and Treatment
1998 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Alexandre Oliveira Ferreira, Catarina Fidalgo, Carolina Palmela, Maria Pia Costa Santos, Joana Torres, Joana Nunes, Rui Loureiro, Rosa Ferreira, E. Barjas, L Glória, A. Santos, Marília Cravo,
<b><i>Background:</i></b> Colorectal cancer (CRC) is the first cause of cancer-related mortality in Portugal. CRC screening reduces disease-specific mortality. Colonoscopy is currently the preferred method for screening as it may contribute to the reduction of CRC incidence. This beneficial effect is strongly associated with the adenoma detection rate (ADR). <b><i>Aim:</i></b> Our aim was to evaluate the quality of colonoscopy at our unit by measuring the ...
Tópico(s): Gastric Cancer Management and Outcomes
2016 - Karger Publishers | GE Portuguese Journal of Gastroenterology
Produção Nacional
Revisado por pares
Beatriz de Almeida Matos, Bruno Pereira, Carolina Ribeiro Santana, Fabrício Amorim, Leonardo Lenin Covezzi Do Val Santos, Lucas Cravo de Oliveira,
O presente artigo busca caracterizar a vulnerabilidade socioepidemiológica a que estão sujeitos os povos indígenas isolados e de recente contato. Por meio de exemplos históricos, procuramos ilustrar como as epidemias decorrentes de processos de contato são capazes de dizimar populações inteiras. Apresentamos e analisamos a legislação brasileira específica que garante o direito à saúde para estes povos para, em seguida, exemplificar como o Estado brasileiro a está descumprindo. Por fim, concluímos ...
Tópico(s): Indigenous Health and Education
2021 - National University of Colombia | Mundo Amazónico
Paula Ferreira, Marília Cravo, Catarina Sousa Guerreiro, Lourdes Tavares, Paula Moura Santos, Miguel Brito,
Crohn's disease (CD) is a multifactorial disease where resistance to apoptosis is one major defect. Also, dietary fat intake has been shown to modulate disease activity. We aimed to explore the interaction between four single nucleotide polymorphisms (SNPs) in apoptotic genes and dietary fat intake in modulating disease activity in CD patients.Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) techniques were used to analyze Caspase9+93C/T, FasLigand-843C/T, Peroxisome ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2010 - Elsevier BV | Clinical Nutrition
Marília Cravo, S. Velho, Joana Torres, Maria Pia Costa Santos, Carolina Palmela, Rita Cruz, João Strecht, Rui Maio, Vickie E. Baracos,
Background and aims The prognostic value of body composition analysis in patients with Crohn's disease (CD) is poorly explored. The aims of the present study were to assess fat and skeletal muscle compartments including muscle radiation attenuation (MA) in patients with CD, and to analyze its predictive value to identify complicated phenotypes. Methods Seventy one patients with CD who have had an abdominal CT within one month of clinical, laboratory, and endoscopic evaluation were included. Skeletal ...
Tópico(s): Stoma care and complications
2017 - Elsevier BV | Clinical Nutrition ESPEN
Edivaldo do Nascimento Duda, Daniel José Cardoso da Silva, Umbelina Cravo Teixeira Lagióia, Marco Aurélio dos Santos,
Objetivo: Analisar a relação entre a Cultura Sustentável e os drivers de valor das companhias de capital aberto listadas brasileiras no período de 2006 a 2020. Referencial teórico: O quadro teórico aborda, principalmente, temas como sustentabilidade, Índice de Sustentabilidade Empresarial (ISE), Governança Ambiental, Social e Corporativa e Responsabilidade Social Corporativa (RSC), bem como as relações entre os desempenhos ambiental e financeiro no contexto empresarial. Método: Utilizou-se o modelo ...
Tópico(s): Business and Management Studies
2022 - CENTRO UNIVERSITARIO FEI | Revista de Gestão Social e Ambiental
Produção Nacional
Breno Régis Santos, Renato Paiva, Raírys Cravo Nogueira, Lenaldo Muniz de Oliveira, Diogo Pedrosa Corrêa da Silva, Cristiano Martinotto, Fernanda Pereira Soares, Patrícia Duarte de Oliveira Paiva,
Por apresentar dormência em suas sementes, a propagação do pequizeiro necessita de estudos para a obtenção de mudas por via assexuada. Este trabalho teve como objetivo contribuir para o estabelecimento de um protocolo de micropropagação de pequizeiro. Para indução de brotações, os explantes foram inoculados em meio WPM com diferentes concentrações de BAP e ANA. Para a indução de raízes, brotações obtidas in vitro foram transferidas para meio WPM suplementado com diferentes concentrações de AIB e ...
Tópico(s): Pineapple and bromelain studies
2006 - Sociedade Brasileira de Fruticultura | Revista Brasileira de Fruticultura
C Gouveia, Rui Loureiro, Rosa Ferreira, Alexandre Oliveira Ferreira, A. Santos, Maria Pia Costa Santos, Carolina Palmela, Marília Cravo,
The prevalence of choledocholithiasis among patients with acute cholecystitis is estimated to be between 9 and 16.5%. There are no validated algorithms to predict choledocholithiasis in this group of patients.The aim of this study was to evaluate the performance of the choledocholithiasis diagnostic score proposed by the American Society for Gastrointestinal Endoscopy, in patients with acute cholecystitis.A retrospective cross-sectional study, covering a 4-year period at a secondary care hospital, ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2017 - Karger Publishers | GE Portuguese Journal of Gastroenterology
Produção Nacional
Revisado por pares
Kioshy Santos de Assis, Carlos Guilherme Cravo Schuabb, Marcella Araujo Lage, Matheus Paranhos Pereira Gonçalves, Diego Pereira-Dias, Oscar R. Mattos,
Slow Strain Rate Tests (SSRT) is a methodology to assess the influence of hydrogen in stress corrosion cracking. However, additional information correlating SSRT and hydrogen permeation might provide a better understanding of the influence of hydrogen on susceptibility to failure of materials. This paper presents a new methodology connecting SSRT with hydrogen permeation tests in the presence of hydrogen. The internal part of an SSRT specimen was used for hydrogen generation, whereas its external ...
Tópico(s): Fatigue and fracture mechanics
2019 - Elsevier BV | Corrosion Science
Cristina Amaro, Mariana Cravo, Cândida Fernandes, Raquel Santos, Margarida Gonçalo,
... for more papers by this authorMariana Cravo, Mariana Cravo Department of Dermatology, Hospitais da Universidade de Coimbra, Coimbra, PortugalSearch for more papers by this authorCândida Fernandes, Cândida Fernandes Department of Dermatology, Hospital de Curry Cabral, 1069-166 Lisbon, PortugalSearch for more papers by this authorRaquel Santos, Raquel Santos Department of Dermatology, Hospital de Curry ... for more papers by this authorMariana Cravo, Mariana Cravo Department of Dermatology, Hospitais da Universidade de Coimbra, Coimbra, PortugalSearch for more papers by this authorCândida Fernandes, Cândida Fernandes Department of Dermatology, Hospital de Curry Cabral, 1069-166 Lisbon, PortugalSearch for more papers by this authorRaquel Santos, Raquel Santos Department of Dermatology, Hospital de Curry ...
Tópico(s): Drug-Induced Adverse Reactions
2012 - Wiley | Contact Dermatitis