FROM A CORRESPONDENT, FROM OUR SPECIAL CORRESPONDENT, From Our Science Correspondent, FROM OUR LABOUR CORRESPONDENT, FROM OUR OWN CORRESPONDENT, FROM OUR CORRESPONDENT, FROM OUR AERONAUTICAL CORRESPONDENT, From Our Special Correspondent, FROM OUR UNITED NATIONS CORRESPONDENT, FROM OUR DIPLOMATIC CORRESPONDENT, From Our Parliamentary Correspondent, From Our Political Correspondent, From Our Own Correspondent, FROM OUR NAVAL CORRESPONDENT, From Our United Nations Correspondent, FROM OUR POLITICAL CORRESPONDENT, From Our Aeronautical Correspondent, D. KILHAM ROBERTS, , ALLEN LANE, , CHERWELL., D. BUCKS., DESMOND DONNELLY., By The Earl of Lytton, HERBERT W. MILES., F. L. COPPERMAN, , Dr. M. A. Murray, J. N. E., A correspondent, From Our Olympic Games Correspondents, FROM OUR RUGBY FOOTBALL CORRESPONDENT, FROM OUR CRICKET CORRESPONDENT, From Our Motoring Correspondent, By Our City Editor,
... In National Interest, Turkey's New Power Station Sariyer Dam Project, No Turkish Troops In Iraq Emphatic ...
1956 - Gale Group | TDA
Sajjad Rahmani Dabbagh, Misagh Rezapour Sarabi, Mehmet Tugrul Birtek, Nur Mustafaoğlu, Yu Shrike Zhang, Savaş Taşoğlu,
... 8888-6106 Department of Mechanical Engineering, Koç University, Sariyer, Istanbul, Turkey Koç University Arçelik Research Center for Creative Industries (KUAR), Koç University, Sariyer, Istanbul, Turkey Koc University Is Bank Artificial Intelligence Lab (KUIS AILab), Koç University, Sariyer, Istanbul, TurkeySearch for more papers by this authorMisagh ... Rezapour Sarabi Department of Mechanical Engineering, Koç University, Sariyer, Istanbul, TurkeySearch for more papers by this authorMehmet ... Tugrul Birtek Department of Mechanical Engineering, Koç University, Sariyer, Istanbul, TurkeySearch for more papers by this authorNur ...
Tópico(s): Neuroscience and Neural Engineering
2022 - Wiley | Aggregate
Ahmet M. Akoğlu, Sigurjón Jónsson, Teng Wang, Ziyadin Çakır, Uğur Doğan, Semih Ergintav, Batuhan Osmanoğlu, Guangcai Feng, Cengiz Zabcı, Alpay Özdemir, Ö. Emre,
... Istanbul Technical University, Department of Geology, Ayazağa Yerleşkesi, Sarıyer 34469, Istanbul, Turkey. Search for other works by ... Faculty of Mines, Istanbul Technical University, Ayazağa Yerleşkesi, Sarıyer 34469, Istanbul, Turkey, ziyadin.cakir@itu.edu.trzabci@ ... Faculty of Mines, Istanbul Technical University, Ayazağa Yerleşkesi, Sarıyer 34469, Istanbul, Turkey, ziyadin.cakir@itu.edu.trzabci@ ...
Tópico(s): Seismic Waves and Analysis
2018 - Seismological Society of America | Bulletin of the Seismological Society of America
... tekerrür eğrileri oluşturulmuştur. Kartal MGİ haricinde 6 istasyonda (Sarıyer, Kumköy, Florya, Çorlu, Göztepe ve Şile) belirgin artış eğilimleri belirlenmiştir. Bir örnek olarak, Sarıyer meteoroloji istasyonunun 5 saatlik standart süreli 2 yıl ... ve ikinci dönem hesaplanan bağıl farkları %30 ve Sarıyer’de bulunan Bekar deresinde Q500 taşkın debisindeki %60 ...
Tópico(s): Flood Risk Assessment and Management
2020 - | Teknik Dergi
Michael Ditiatkovski, Nigora Mukhamedova, Dragana Dragoljevic, Anh Hoang, Hann Low, Tatiana Pushkarsky, Ying Fu, Irena Carmichael, Andrew F. Hill, Andrew Murphy, Michael Bukrinsky, Dmitri Sviridov,
... S. Ahooyi T.M. Khalili K. Amini S. Sariyer I.K. HIV-1 Nef is released in ... S. Ahooyi T.M. Khalili K. Amini S. Sariyer I.K. HIV-1 Nef is released in ... S. Ahooyi T.M. Khalili K. Amini S. Sariyer I.K. HIV-1 Nef is released in ...
Tópico(s): Reproductive System and Pregnancy
2020 - Elsevier BV | Journal of Biological Chemistry
Çiğdem Altıntaş, Sadiye Velioğlu, Seda Keskın,
... Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, Istanbul 34450, TurkeyMore by Cigdem Altintas, Sadiye VeliogluSadiye ... Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, Istanbul 34450, TurkeyMore by Sadiye Velioglu, and Seda ... Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, Istanbul 34450, Turkey*Email: [email protected]More by ...
Tópico(s): Catalytic Processes in Materials Science
2019 - American Chemical Society | ACS Applied Materials & Interfaces
... type chalcopyrite and auriferous pyrite deposits in the Sariyer area of Turkey. The spontaneous polarization method was ...
Tópico(s): Earthquake Detection and Analysis
1954 - Society of Exploration Geophysicists | Geophysics
Eberhard Kaniuth, Anthony Lau, A. Ülger,
... A. Ülger Department of Mathematics, Koc University, 34450 Sariyer, Istanbul, Turkey, [email protected]Search for more papers ... A. Ülger Department of Mathematics, Koc University, 34450 Sariyer, Istanbul, Turkey, [email protected]Search for more papers ...
Tópico(s): Advanced Banach Space Theory
2009 - Wiley | Journal of the London Mathematical Society
Francesca Isabella De-Simone, Rahsan Sariyer, Yolanda-Lopez Otalora, Shadan S. Yarandi, Michael Craigie, Jennifer Gordon, Ilker K. Sariyer,
Objective Patients undergoing immune modulatory therapies for the treatment of autoimmune diseases such as multiple sclerosis, and individuals with an impaired-immune system, most notably AIDS patients, are in the high risk group of developing progressive multifocal leukoencephalopathy (PML), an often lethal disease of the brain characterized by lytic infection of oligodendrocytes in the central nervous system (CNS) with JC virus (JCV). The immune system plays an important regulatory role in controlling ...
Tópico(s): Antenna Design and Analysis
2015 - Public Library of Science | PLoS ONE
... Anatomy, School of Medicine, Koc University, Rumelifeneri Campus, Sariyer, Istanbul 34450, Turkey; cozgur@yahoo.comSearch for more ... Anatomy, School of Medicine, Koc University, Rumelifeneri Campus, Sariyer, Istanbul 34450, Turkey; cozgur@yahoo.comSearch for more ...
Tópico(s): Sulfur Compounds in Biology
2015 - Wiley | Movement Disorders
Özgür Can Eren, Alberto Ortíz, Barış Afşar, Adrian Covic, Masanari Kuwabara, Miguel A. Lanaspa, Richard J. Johnson, Mehmet Kanbay,
... Medicine, Koç University School of Medicine, Rumelifeneri Yolu, Sariyer 34450, Istanbul, Turkey. Email E-mail Address: [email ... Medicine, Koç University School of Medicine, Rumelifeneri Yolu, Sariyer 34450, Istanbul, Turkey. Email [email protected]edu.trReferences1. ...
Tópico(s): Hormonal Regulation and Hypertension
2018 - Lippincott Williams & Wilkins | Hypertension
Rebecca Vigen, Patricia Kutscher, Fernabelle Fernandez, Amy Yu, Bryan Bertulfo, Ibrahim A. Hashim, Kyle Molberg, Deborah B. Diercks, Jeffery C. Metzger, José Constancio Ruiz Soto, Dergham Alzubaidy, Lorie Thibodeaux, José A. Joglar, James A. de Lemos, Sandeep R. Das,
... 234-236), Online publication date: 1-Feb-2022. Sarıyer G and Ataman M (2020) The likelihood of ... 21:1, Online publication date: 1-Dec-2021. Sariyer G and Ataman M (2021) How machine learning ...
Tópico(s): Coronary Interventions and Diagnostics
2018 - Lippincott Williams & Wilkins | Circulation
Prasanta K. Dash, Rafal Kaminski, Ramona Bella, Hang Su, Saumi Mathews, Taha Mohseni Ahooyi, Chen Chen, Pietro Mancuso, Rahsan Sariyer, Pasquale Ferrante, Martina Donadoni, Jake A. Robinson, Brady Sillman, Zhiyi Lin, James R. Hilaire, Mary Banoub, Monalisha Elango, Nagsen Gautam, R. Lee Mosley, Larisa Y. Poluektova, JoEllyn McMillan, Aditya N. Bade, Santhi Gorantla, Ilker K. Sariyer, Tricia H. Burdo, Won‐Bin Young, Shohreh Amini, Jennifer Gordon, Jeffrey M. Jacobson, Benson Edagwa, Kamel Khalili, Howard E. Gendelman,
Abstract Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent infectious reservoirs in HIV-1 infected humanized mice. HIV-1 subgenomic DNA fragments, spanning the long terminal repeats and the Gag gene, are excised in vivo, resulting in elimination of integrated proviral DNA; virus is not detected in blood, ...
Tópico(s): Cytomegalovirus and herpesvirus research
2019 - Nature Portfolio | Nature Communications
... Making Choices Ahmet İcduygu, Ahmet İcduygu Koc University, Sarıyer/İstanbul, TurkeySearch for more papers by this authorDeniz ... this author Ahmet İcduygu, Ahmet İcduygu Koc University, Sarıyer/İstanbul, TurkeySearch for more papers by this authorDeniz ...
Tópico(s): Migration and Labor Dynamics
2019 - Wiley | International Migration
Pietro Mancuso, Chen Chen, Rafal Kaminski, Jennifer Gordon, Shuren Liao, Jake A. Robinson, Mandy D. Smith, Hong Liu, Ilker K. Sariyer, Rahsan Sariyer, Tiffany A. Peterson, Martina Donadoni, Jaclyn B. Williams, Summer Siddiqui, Bruce A. Bunnell, Binhua Ling, Andrew G. MacLean, Tricia H. Burdo, Kamel Khalili,
Abstract Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non-human primate model of HIV infection, with adeno-associated virus 9 (AAV9)-CRISPR/Cas9 gene editing construct designed for eliminating proviral SIV DNA, leads to broad distribution of editing molecules and precise cleavage and removal of fragments of the integrated proviral DNA from the genome of infected blood cells ...
Tópico(s): Cytomegalovirus and herpesvirus research
2020 - Nature Portfolio | Nature Communications
Tricia H. Burdo, Chen Chen, Rafal Kaminski, Ilker K. Sariyer, Pietro Mancuso, Martina Donadoni, Mandy D. Smith, Rahsan Sariyer, Maurizio Caocci, Shuren Liao, Hong Liu, Wenwen Huo, Huaqing Zhao, John Misamore, Mark G. Lewis, Vahan Simonyan, Elaine E. Thompson, Ethan Xu, Thomas J. Cradick, Jennifer Gordon, Kamel Khalili,
Abstract In this study, we demonstrate the safety and utility of CRISPR-Cas9 gene editing technology for in vivo editing of proviral DNA in ART-treated, virally controlled simian immunodeficiency virus (SIV) infected rhesus macaques, an established model for HIV infection. EBT-001 is an AAV9-based vector delivering SaCas9 and dual guide RNAs designed to target multiple regions of the SIV genome: the viral LTRs, and the Gag gene. The results presented here demonstrate that a single IV inoculation ...
Tópico(s): Cytomegalovirus and herpesvirus research
2023 - Springer Nature | Gene Therapy
Meliz Akyol Alay, Hayriye Eşbah Tunçay, Keith Clarke,
... a case study, we applied the model to Sariyer, Istanbul, for the year 2045, where transportation infrastructure ...
Tópico(s): Urban Green Space and Health
2021 - American Society of Civil Engineers | Journal of Urban Planning and Development
Ayşegül Bozdemir, Eda Şensu, Emine Şükran Okudan, Beraat Özçelik, Aysun Yücetepe,
... Trade Ltd., Katar Street, Teknokent ARI-3, B110, Sarıyer, 34467, Istanbul, Turkey Contribution: MethodologySearch for more papers ... Trade Ltd., Katar Street, Teknokent ARI-3, B110, Sarıyer, 34467, Istanbul, Turkey Contribution: MethodologySearch for more papers ...
Tópico(s): Botanical Research and Applications
2022 - Wiley | Journal of Food Processing and Preservation
Mert Ersen, Ali Hakan Büyüklü, Semra Taşabat Erpolat,
... or injured traffic accidents between 2010–2017 in Sarıyer district of Istanbul, Turkey’s largest city in ...
Tópico(s): Spatial and Panel Data Analysis
2021 - Multidisciplinary Digital Publishing Institute | Sustainability
Rahsan Sariyer, Francesca Isabella De-Simone, Martina Donadoni, Jan B. Hoek, Sulie L. Chang, Ilker K. Sariyer,
Heavy and chronic ethanol (EtOH) exposure can cause significant structural and functional damage to the adult brain. The most devastating consequence of EtOH exposure is the neurotoxicity associated with the depletion of neurons. Regulation of splice variants in the brain can modulate protein functions, which may ultimately affect behaviors associated with alcohol dependence and EtOH-mediated neurotoxicity. As alcohol consumption is associated with neurotoxicity, it is possible that altered splicing ...
Tópico(s): Adipose Tissue and Metabolism
2017 - Wiley | Alcoholism Clinical and Experimental Research
... Google Scholar In this issue of Molecular Therapy, Sariyer et al.2Sariyer I.K. Gordon J. Burdo ... has not been reported. Taking the repurposing approach, Sariyer et al.2Sariyer I.K. Gordon J. Burdo ... by blocking the viral RdRp (Figure 1). First, Sariyer et al.2Sariyer I.K. Gordon J. Burdo ... of rilpivirine against ZIKV in cell culture. Second, Sariyer et al.2Sariyer I.K. Gordon J. Burdo ... mapped to the viral NS5 RdRp gene. Third, Sariyer et al.2Sariyer I.K. Gordon J. Burdo ... PubMed Scopus (117) Google Scholar The study by Sariyer et al.2Sariyer I.K. Gordon J. Burdo ...
Tópico(s): Virology and Viral Diseases
2019 - Elsevier BV | Molecular Therapy
... Advanced Materials Group (AMG), Department of Mechanical Engineering, Sariyer, İstanbul, TurkeySearch for more papers by this authorD. ... Advanced Materials Group (AMG), Department of Mechanical Engineering, Sariyer, İstanbul, Turkey Koç University Surface Science and Technology Center (KUYTAM), Sariyer, İstanbul, TurkeySearch for more papers by this author ... Advanced Materials Group (AMG), Department of Mechanical Engineering, Sariyer, İstanbul, TurkeySearch for more papers by this authorD. ... Advanced Materials Group (AMG), Department of Mechanical Engineering, Sariyer, İstanbul, Turkey Koç University Surface Science and Technology ...
Tópico(s): Additive Manufacturing and 3D Printing Technologies
2018 - Wiley | Ceramic transactions /Ceramic transactions
Çiğdem Göksel, Ahmet Özgür Doğru,
... in the protected zones of Bosphorus specifically in Sariyer District. In this context, Landsat imageries dated 2005 ... Front and Back View Zones of Bosphorus in Sariyer district using 2005 and 2017 dated IKONOS satellite images. The map of Sariyer district produced in 1960 was considered as the ... based on the Bosphorus Law No. 2960 in Sariyer District.
Tópico(s): Wildlife-Road Interactions and Conservation
2018 - Association of Food Technology, Turkey | International Journal of Engineering and Geosciences
Ilker K. Sariyer, Rahsan Sariyer, Jessica Otte, Jennifer Gordon,
Objective PML is a rare and fatal demyelinating disease of the CNS caused by the human polyomavirus, JC virus (JCV), which occurs in AIDS patients and those on immunosuppressive monoclonal antibody therapies (mAbs). We sought to identify mechanisms that could stimulate reactivation of JCV in a cell culture model system and targeted pathways which could affect early gene transcription and JCV T-antigen production, which are key steps of the viral life cycle for blocking reactivation of JCV. Two important ...
Tópico(s): Energy Harvesting in Wireless Networks
2016 - Public Library of Science | PLoS ONE
Selin Sarıyer, Arpita Ghosh, Sevde Nazli Dambasan, El Mahdi Halim, Mama El Rhazi, Hubert Perrot, Ozlëm Sel, Rezan Demir‐Cakan,
Rechargeable batteries employing aqueous electrolytes are more reliable and cost-effective as well as possess high ionic conductivity compared to the flammable organic electrolyte solutions. Among these types of batteries, aqueous batteries with multivalent ions attract more attention in terms of providing high energy density. Herein, electrochemical behavior of an organic electrode based on a highly aromatic polymer containing 2,3-diaminophenazine repeating unit, namely poly(ortho-phenylenediamine) ( ...
Tópico(s): Advanced Battery Materials and Technologies
2022 - American Chemical Society | ACS Applied Materials & Interfaces
E. M. Abdelrahman, Khalid S. Soliman, Khalid S. Essa, Eid R. Abo‐Ezz, T. M. El‐Araby,
... data (SP anomalies over a sulfide ore deposit, Sariyer, Turkey and over a Malachite Mine, Jefferson County, ...
Tópico(s): Geochemistry and Geologic Mapping
2009 - Taylor & Francis | Exploration Geophysics
... to: Bruce Rankin, Department of Sociology, Koc University, Sariyer-Istanbul, Turkey 80910. E-mail: brankin@ku.edu. ...
Tópico(s): Health disparities and outcomes
2002 - Oxford University Press | Social Problems
... umich.edu); Sonmez: Department of Economics, Koc University, Sariyer, 80910, Istanbul, Turkey (e-mail: tsonmez@ku.edu. ...
Tópico(s): Housing Market and Economics
2002 - American Economic Association | American Economic Review
Ilker K. Sariyer, Kamel Khalili, Mahmut Safak,
Previous studies have demonstrated that the JC virus (JCV) late regulatory protein agnoprotein is phosphorylated by the serine/threonine-specific protein kinase-C (PKC) and mutants of this protein at the PKC phosphorylation sites exhibit defects in the viral replication cycle. We have now investigated whether agnoprotein phosphorylation is regulated by PP2A, a serine/threonine-specific protein phosphatase and whether JCV small t antigen (Sm t-Ag) is involved in this regulation. Protein–protein interaction ...
Tópico(s): Respiratory viral infections research
2008 - Elsevier BV | Virology
Luca Romagnoli, Ilker K. Sariyer, Jacqueline Tung, Mariha Feliciano, Bassel E. Sawaya, Luis Del Valle, Pasquale Ferrante, Kamel Khalili, Mahmut Safak, Martyn K. White,
JC virus (JCV) is a human polyomavirus that can emerge from a latent state to cause the cytolytic destruction of oligodendrocytes in the brain resulting in the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). Previous studies described a cis-acting transcriptional regulatory element in the JCV non-coding control region (NCCR) that is involved in the response of JCV to cytokines. This consists of a 23 base pair GGA/C rich sequence (GRS) near the replication origin (5112 to + ...
Tópico(s): Antenna Design and Analysis
2008 - Elsevier BV | Virology