Satoru Yamagishi, Falko Hampel, Katsuhiko Hata, Daniel del Toro, Manuela Schwark, Elena Kvachnina, Martin Bastmeyer, Toshihide Yamashita, Victor Tarabykin, Rüdiger Klein, Joaquim Egea,
... repulsive guidance cues for Unc5-positive neurons Satoru Yamagishi Satoru Yamagishi Department of Molecular Neurobiology, Max Planck Institute ... Search for more papers by this author Satoru Yamagishi Satoru Yamagishi Department of Molecular Neurobiology, Max Planck Institute of ...
Tópico(s): Developmental Biology and Gene Regulation
2011 - Springer Nature | The EMBO Journal
Takamichi Yamagishi, Satoru Ikeda, Masanobu Yatagai, Motowo Yamaguchi, Mitsuhiko Hida,
Electrostatic interaction between the amino group of the achiral 3-dimethylaminopropylidenebismethylenebis(diphenylphosphine)(1) and the carboxy group of the substrate enabled an effective 1,4-asymmetric induction in the RhI-catalysed hydrogenation of didehydrodipeptides, to give (S,S)- or (R,R)-products selectively. The selectivity reached up to 94% diastereoisomeric excess with acetyl didehydrodipeptides and 92% with benzyloxycarbonyl substrates.
Tópico(s): Topic Modeling
1988 - | Journal of the Chemical Society. Perkin transactions I/Journal of the Chemical Society. Perkin transactions. I
Yuka Yamasaki, Nobuaki Shime, Takako Miyazaki, Masaaki Yamagishi, Satoru Hashimoto, Yoshifumi Tanaka,
Perioperative fast-track management has gained wide acceptance in the field of neonatal corrective heart surgery. We have examined its impact on morbidity outcomes. Between 1997 and 2009, 52 consecutive neonates underwent corrective repair of congenital heart defects on cardiopulmonary bypass. Fast-track management was introduced in 2006 with the aim of simplifying care; it includes early postoperative extubation with low-dose fentanyl and an pulse oximeter oxygen saturation (SpO2) target of ≤95%, ...
Tópico(s): Cardiac and Coronary Surgery Techniques
2011 - Springer Science+Business Media | Journal of Anesthesia
S. Fukuda, Yasufumi Hino, Susumu Ohashi, Tomoshi Takeda, Hiroyuki Yamagishi, Satoru Shinke, Kenji Komori, M. Uno, Yoshiyuki Akiyama, K. Kawasaki, Ali Hajimiri,
A new interconnect solution with plastic waveguide is demonstrated. The system consists of a pair of transceivers and a plastic waveguide. Millimeter wave signal is transmitted in a low-cost long piece of solid plastic dielectric acting as a waveguide. The plastic waveguide medium offers a large bandwidth for data communication using mm-wave carrier frequencies. Plastic waveguide interconnects do not require costly electrical-to-optical and optical-to-electrical conversion devices or precise alignment ...
Tópico(s): Advanced Photonic Communication Systems
2011 - Institute of Electrical and Electronics Engineers | IEEE Journal of Solid-State Circuits
Hideaki Oike, Naoki Takemura, Hiromi Kimoto‐Nira, Naoko Yamagishi, Satoru Tomita, Yasuyo Sekiyama, Manabu Wakagi, Mutsumi Sakurai, Katsunari Ippoushi, Chise Suzuki, Masuko Kobori,
Abstract Age-related hearing loss (AHL) is a common disorder associated with aging. In this study, we investigated the effect of the intake of heat-killed Lactococcus lactis subsp. cremoris H61 (strain H61) on AHL in C57BL/6J mice. Measurement of the auditory brainstem response (ABR) demonstrated that female mice at 9 months of age fed a diet containing 0.05% strain H61 for 6 months maintained a significantly lower ABR threshold than control mice. The age-related loss of neurons and hair cells in the ...
Tópico(s): Gut microbiota and health
2016 - Nature Portfolio | Scientific Reports
Tadahiro Numakawa, Satoru Yamagishi, Naoki Adachi, Tomoya Matsumoto, Daisaku Yokomaku, Masashi Yamada, Hiroshi Hatanaka,
Brain-derived neurotrophic factor (BDNF) has been reported to exert an acute potentiation of synaptic activity. Here we examined the action of BDNF on synchronous spontaneous Ca2+ oscillations in cultured cerebral cortical neurons prepared from postnatal 2–3-day-old rats. The synchronous spontaneous Ca2+ oscillations began at approximately DIV 5. It was revealed that voltage-dependent Ca2+ channels and ionotropic glutamate receptors were involved in the synchronous spontaneous oscillatory activity. ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2002 - Elsevier BV | Journal of Biological Chemistry
Satoru Yamagishi, Tomoya Matsumoto, Daisaku Yokomaku, Hiroshi Hatanaka, Koji Shimoke, Masashi Yamada, Toshihiko Ikeuchi,
Tópico(s): Signaling Pathways in Disease
2003 - Elsevier BV | Molecular Brain Research
Previously, we reported that p38, which belongs to the mitogen-activated protein kinase (MAPK) superfamily, has an important role in the induction of apoptosis of cultured cerebellar granule neurons. However, the molecular mechanisms upstream of p38 activation remain unclear. Apoptosis signal-regulating kinase-1 (ASK1), a MAPK kinase kinase (MAPKKK) protein, is known to activate both c-Jun N-terminal kinase (JNK) and p38 via MAPK kinase (MKK) 4/7 and MKK3/6, respectively. Here, we examined whether ASK1 ...
Tópico(s): FOXO transcription factor regulation
2003 - Oxford University Press | The Journal of Biochemistry
Joaquim Egea, Christian Erlacher, Eloi Montañez, Ingo Burtscher, Satoru Yamagishi, Martin Heß, Falko Hampel, Rodrigo Sánchez, Maria Teresa Rodriguez-Manzaneque, Michael R. Bösl, Reinhard Fässler, Heiko Lickert, Rüdiger Klein,
During early mouse development, the anterior visceral endoderm (AVE) secretes inhibitor and activator signals that are essential for establishing the anterior-posterior (AP) axis of the embryo and for restricting mesoderm formation to the posterior epiblast in the primitive streak (PS) region. Here we show that AVE cells have an additional morphogenetic function. These cells express the transmembrane protein FLRT3. Genetic ablation of FLRT3 did not affect the signaling functions of the AVE according ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2008 - Cold Spring Harbor Laboratory Press | Genes & Development
Satoru Yamagishi, Yoshihisa Koyama, Taiichi Katayama, Manabu Taniguchi, Junichi Hitomi, Masaaki Kato, Masashi Aoki, Yasuto Itoyama, Shinsuke Kato, Masaya Tohyama,
Neuronal Lewy body-like hyaline inclusions (LBHI) and astrocytic hyaline inclusions (Ast-HI) containing mutant Cu/Zn superoxide dismutase 1 (SOD1) are morphological hallmarks of familial amyotrophic lateral sclerosis (FALS) associated with mutant SOD1. However, the mechanisms by which mutant SOD1 contributes to formation of LBHI/Ast-HI in FALS remain poorly defined. Here, we report induction of LBHI/Ast-HI-like hyaline inclusions (LHIs) in vitro by ER stress in neuroblastoma cells. These LHI closely ...
Tópico(s): Neurological diseases and metabolism
2007 - Public Library of Science | PLoS ONE
Fumiaki Mimura, Satoru Yamagishi, Nariko Arimura, Masashi Fujitani, Takekazu Kubo, Kozo Kaibuchi, Toshihide Yamashita,
Myelin-associated glycoprotein (MAG) and Nogo are potent inhibitors of neurite outgrowth from a variety of neurons, and they have been identified as possible components of the central nervous system myelin that prevents axonal regeneration in the adult vertebrate central nervous system. The activation of RhoA and Rho-kinase is reported to be an essential part of the signaling mechanism of these proteins. Here, we report that the collapsing response mediator protein-2 (CRMP-2) is phosphorylated by ...
Tópico(s): Cellular Mechanics and Interactions
2006 - Elsevier BV | Journal of Biological Chemistry
Katsuhiko Hata, Masashi Fujitani, Yuichi Yasuda, Hideo Doya, Tomoko Saito, Satoru Yamagishi, Bernhard K. Mueller, Toshihide Yamashita,
Repulsive guidance molecule (RGM) is a protein implicated in both axonal guidance and neural tube closure. We report RGMa as a potent inhibitor of axon regeneration in the adult central nervous system (CNS). RGMa inhibits mammalian CNS neurite outgrowth by a mechanism dependent on the activation of the RhoA–Rho kinase pathway. RGMa expression is observed in oligodendrocytes, myelinated fibers, and neurons of the adult rat spinal cord and is induced around the injury site after spinal cord injury. ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2006 - Rockefeller University Press | The Journal of Cell Biology
Toshihide Yamashita, Masashi Fujitani, Katsuhiko Hata, Fumiaki Mimura, Satoru Yamagishi,
The pan-neurotrophin receptor p75NTR belongs to a large family of receptors, which includes tumor necrosis factor receptors, Fas and approximately 25 other members. The p75NTR is the first receptor to be cloned molecularly. Recent years have seen the emergence of a consensus regarding the signaling pathways activated by p75NTR and its potential biological function, although receptor characterization had not been targeted for some years. We now know that p75NTR has surprisingly diverse effects, ranging ...
Tópico(s): Cell Adhesion Molecules Research
2005 - Springer Science+Business Media | Kaibogaku Zasshi
Satoru Yamagishi, Masashi Fujitani, Katsuhiko Hata, Keiko Kitajo, Fumiaki Mimura, Hideki Abe, Toshihide Yamashita,
Local axon degeneration is a common pathological feature of many neurodegenerative diseases, whereas the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons, termed "Wallerian degeneration," as a model to examine the possible involvement of Rho. Nogo-66, a myelin-derived inhibitor of axon regeneration, significantly accelerated axon degeneration of the dorsal root ganglion explant in vitro, whereas inhibiting Rho-kinase activity abolished ...
Tópico(s): Plant Molecular Biology Research
2005 - Elsevier BV | Journal of Biological Chemistry
Tomoya Matsumoto, Tadahiro Numakawa, Daisaku Yokomaku, Naoki Adachi, Satoru Yamagishi, Yumiko Numakawa, Hiroshi Kunugi, Takahisa Taguchi,
The mechanisms underlying BDNF-modulated neurotransmitter release remain elusive. Here, we found that 24-h exposure of postnatal cortical neurons to BDNF potentiated depolarization-evoked glutamate and GABA release in a protein synthesis-dependent manner. BDNF-potentiated glutamate release occurred through the PLC-gamma and MAPK pathways. The expression of synapsin I, synaptotagmin, and synaptophysin, but not of syntaxin or SNAP25, increased through the PLC-gamma and MAPK pathways. In contrast, ...
Tópico(s): Neuroscience and Neuropharmacology Research
2005 - Elsevier BV | Molecular and Cellular Neuroscience
Toshihide Yamashita, Masashi Fujitani, Satoru Yamagishi, Katsuhiko Hata, Fumiaki Mimura,
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2005 - Springer Science+Business Media | Molecular Neurobiology
Satoru Yamagishi, Tomoya Matsumoto, Tadahiro Numakawa, Daisaku Yokomaku, Naoki Adachi, Hiroshi Hatanaka, Masashi Yamada, Koji Shimoke, Toshihiko Ikeuchi,
We have recently reported that the ASK1-p38 MAPK pathway has an important role in the low potassium (LK)-induced apoptosis of cultured cerebellar granule neurons. In the present study, we observed that ERK1/2 were significantly activated 6 h after a change of medium from HK (high potassium) to LK. In addition, U0126, a specific inhibitor of MEKs, remarkably prevented the apoptosis of cultured cerebellar granule neurons. Then, we examined the mechanism underlying the activation of ERK1/2 in the LK- ...
Tópico(s): RNA regulation and disease
2005 - Elsevier BV | Brain Research
Kayoko Oono, Takunari Yoneda, Takayuki Manabe, Satoru Yamagishi, Satoshi Matsuda, Junichi Hitomi, Shingo Miyata, Tatsuyoshi Mizuno, Kazunori Imaizumi, Taiichi Katayama, Masaya Tohyama,
Tópico(s): Autophagy in Disease and Therapy
2004 - Elsevier BV | Neurochemistry International
Junichi Hitomi, Taiichi Katayama, Yutaka Eguchi, Takashi Kudo, Manabu Taniguchi, Yoshihisa Koyama, Takayuki Manabe, Satoru Yamagishi, Yoshio Bandô, Kazunori Imaizumi, Yoshihide Tsujimoto, Masaya Tohyama,
Recent studies have suggested that neuronal death in Alzheimer's disease or ischemia could arise from dysfunction of the endoplasmic reticulum (ER). Although caspase-12 has been implicated in ER stress-induced apoptosis and amyloid-beta (Abeta)-induced apoptosis in rodents, it is controversial whether similar mechanisms operate in humans. We found that human caspase-4, a member of caspase-1 subfamily that includes caspase-12, is localized to the ER membrane, and is cleaved when cells are treated with ...
Tópico(s): Autophagy in Disease and Therapy
2004 - Rockefeller University Press | The Journal of Cell Biology
Yuiko Hasegawa, Masashi Fujitani, Katsuhiko Hata, Masaya Tohyama, Satoru Yamagishi, Toshihide Yamashita,
Several myelin-derived proteins have been identified as components of the CNS myelin that prevents axonal regeneration in the adult vertebrate CNS. Activation of RhoA has been shown to be an essential part of the signaling mechanism of these proteins. Here we report an additional signal, which determines whether these proteins promote or inhibit axon outgrowth. Myelin-associated glycoprotein (MAG) and Nogo trigger the intracellular elevation of Ca2+ as well as the activation of PKC, presumably mediated ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2004 - Society for Neuroscience | Journal of Neuroscience
Masashi Fujitani, Satoru Yamagishi, Yong Ho, Katsuhiko Hata, Tateki Kubo, Hidetoshi Ino, Masaya Tohyama, Toshihide Yamashita,
Abstract In axotomized adult neurons, a process of axonal regrowth and re‐establishment of the neuronal function has to be activated. Developmentally regulated factors may be reactivated during neuronal regeneration. Here we identify a gene, previously designated P311, that is up‐regulated in the axotomized facial motoneurons. Ectopically expressed P311 localizes in the cytoplasm and the nucleus. Over‐expression of P311 induces p21 WAF1/Cip1 expression, leading PC12 cells to differentiate and to ...
Tópico(s): Facial Nerve Paralysis Treatment and Research
2004 - Wiley | Journal of Neurochemistry
Masashi Fujitani, Akiko Honda, Katsuhiko Hata, Satoru Yamagishi, Masaya Tohyama, Toshihide Yamashita,
The Rho family of small GTPases, key regulators of the actin cytoskeleton in eukaryotic cells, is implicated in the control of neuronal morphology. Here, we report that neurotrophin dependent cytoskeletal changes, characteristic of the phenotype of Rac1, in the hippocampal neurons or PC12 cells are inhibited by the disruption of lipid raft integrity. Activation of Rac1 induced by NGF is impaired in cholesterol-depleted PC12 cells. Pretreatment with gammaGTP shifted significant amount of Rac1, presumably ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2004 - Elsevier BV | Biochemical and Biophysical Research Communications
Yuiko Hasegawa, Satoru Yamagishi, Masashi Fujitani, Toshihide Yamashita,
Tópico(s): Signaling Pathways in Disease
2004 - Elsevier BV | Biotechnology annual review
Satoru Yamagishi, Masashi Yamada, Yasuyuki Ishikawa, Tomoya Matsumoto, Toshihiko Ikeuchi, Hiroshi Hatanaka,
Cultured rat cerebellar granule neurons are widely used as a model system for studying neuronal apoptosis. After maturation by culturing in medium containing 26 mmpotassium (high K+), changing to medium containing 5 mm potassium (low K+; LK) rapidly induces neuronal apoptosis. Then over 50% of granule cells die within 24 h. However, the molecular mechanisms by which the LK-induced apoptosis occurs in cultured cerebellar granule cells remain unclear. In the present study, we found that p38 MAP kinase ( ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2001 - Elsevier BV | Journal of Biological Chemistry
Tomoya Matsumoto, Tadahiro Numakawa, Naoki Adachi, Daisaku Yokomaku, Satoru Yamagishi, Nobuyuki Takei, Hiroshi Hatanaka,
Brain-derived neurotrophic factor (BDNF) has been reported to play an important role in neuronal plasticity. In this study, we examined the effect of BDNF on an activity-dependent synaptic function in an acute phase. First, we found that short-term treatment (10 min) with BDNF enhanced depolarization-evoked glutamate release in cultured cortical neurons. The enhancement diminished gradually according to the length of BDNF treatment. The BDNF-enhanced release did not require the synthesis of protein ...
Tópico(s): Neuroscience and Neural Engineering
2001 - Wiley | Journal of Neurochemistry
Satoru Yamagishi, Kohei Yamada, Masato Sawada, Suguru Nakano, Norio Mori, Kazunobu Sawamoto, Kohji Sato,
Mammalian netrin family proteins are involved in targeting of axons, neuronal migration, and angiogenesis and act as repulsive and attractive guidance molecules. Netrin-5 is a new member of the netrin family with homology to the C345C domain of netrin-1. Unlike other netrin proteins, murine netrin-5 consists of two EGF motifs of the laminin V domain (LE) and the C345C domain, but lacks the N-terminal laminin VI domain and one of the three LE motifs. We generated a specific antibody against netrin- ...
Tópico(s): Angiogenesis and VEGF in Cancer
2015 - Frontiers Media | Frontiers in Cellular Neuroscience
Tadahiro Numakawa, Nobuyuki Takei, Satoru Yamagishi, Naoto Sakai, Hiroshi Hatanaka,
Brain-derived neurotrophic factor (BDNF) has been suggested to play an important role in neuronal plasticity. In this study, we investigated the effects of BDNF on short-term transmitter release from cultured CNS neurons. Rapid and transient glutamate and aspartate releases induced by BDNF were observed from cultured cortical, hippocampal, striatal and cerebellar neurons. We furthermore investigated the mechanism of release induced by neurotrophins from cerebellar granule cells, since granule cells ...
Tópico(s): Neuroscience and Neuropharmacology Research
1999 - Elsevier BV | Brain Research
Koji Shimoke, Satoru Yamagishi, Masashi Yamada, Toshihiko Ikeuchi, Hiroshi Hatanaka,
Cerebellar granule neurons maintained in medium containing 26 mM potassium or in medium (5 mM potassium) with 50 ng/ml brain-derived neurotrophic factor (BDNF) undergo an apoptotic cell death when exposed to 10 microM LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3-K). To investigate the intracellular signaling mechanism of LY294002-induced apoptosis, the activities of Akt and c-Jun N-terminal kinase (JNK) were measured in cells in HK (26 mM potassium) medium or LK+ (5 mM potassium) medium ...
Tópico(s): Neuroscience and Neuropharmacology Research
1999 - Elsevier BV | Developmental Brain Research
Ikue Tai-Nagara, Yusuke Yoshikawa, Naoko Numata, Tomofumi Ando, Keisuke Okabe, Yuki Sugiura, Masaki Ieda, Nobuyuki Takakura, Osamu Nakagawa, Bin Zhou, Koji Okabayashi, Makoto Suematsu, Yuko Kitagawa, Martin Bastmeyer, Kohji Sato, Rüdiger Klein, Sutip Navankasattusas, Dean Y. Li, Satoru Yamagishi, Yoshiaki Kubota,
The placental labyrinth is the interface for gas and nutrient exchange between the embryo and the mother; hence its proper development is essential for embryogenesis. However, the molecular mechanism underlying development of the placental labyrinth, particularly in terms of its endothelial organization, is not well understood. Here, we determined that fibronectin leucine-rich transmembrane protein 2 (FLRT2), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in ...
Tópico(s): Zebrafish Biomedical Research Applications
2017 - The Company of Biologists | Development
Satoru Yamagishi, Yuki Bando, Kohji Sato,
In mammals, excitatory cortical neurons develop from the proliferative epithelium and progenitor cells in the ventricular zone and subventricular zone, and migrate radially to the cortical plate, whereas inhibitory GABAergic interneurons are born in the ganglionic eminence and migrate tangentially. The migration of newly born cortical neurons is tightly regulated by both extracellular and intracellular signaling to ensure proper positioning and projections. Non-cell-autonomous extracellular molecules, ...
Tópico(s): Neuroscience and Neuropharmacology Research
2021 - Frontiers Media | Frontiers in Cell and Developmental Biology