Produção Nacional
Revisado por pares
Angelo Gava, Cassandro Davi Emer, Evandro Ficagna, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefría,
... reviewAll authorsAngelo Gava , Cassandro Davi Emer , Evandro Ficagna , Saulo Fernandes de Andrade & Alexandre Meneghello Fuentefria https://doi.org/ ...
Tópico(s): Mycotoxins in Agriculture and Food
2021 - Taylor & Francis | Food Additives & Contaminants Part A
Produção Nacional
Revisado por pares
Débora Assumpção Rocha, Elany Barbosa da Silva, Isadora Serraglio Fortes, Marcela Silva Lopes, Rafaela Salgado Ferreira, Saulo Fernandes de Andrade,
Chagas disease and Human African trypanosomiasis (HAT) are important public health issues in Latin American and sub-Saharan African countries, respectively, and are responsible for a significant number of deaths. The drugs currently used to treat Chagas disease and HAT present efficacy, toxicity, and/or resistance issues; thus, there is a clear need for the discovery of novel targets and drug candidates to combat these diseases. In recent years, much effort has been made to find inhibitors of cruzain ...
Tópico(s): Cyclopropane Reaction Mechanisms
2018 - Elsevier BV | European Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Angélica Rocha Joaquim, Bruna Pippi, Maycon Antonio de Cesare, Débora Assumpção Rocha, Roberta Boff, Keli Jaqueline Staudt, Thaís Carine Ruaro, Aline Rigon Zimmer, Bibiana Verlindo de Araújo, Gustavo P. Silveira, Andreza Francisco Martins, Mário Lettieri Teixeira, Francisco P. dos Santos, Alexandre Meneghello Fuentefría, Saulo Fernandes de Andrade,
The combination of tools such as time-kill assay with subsequent application of mathematical modeling can clarify the potential of new antimicrobial compounds, since minimal inhibitory concentration (MIC) value does not provide a very detailed characterization of antimicrobial activity. Recently, our group has reported that the 8-hydroxy-5-quinolinesulfonic acid presents relevant antifungal activity. However, its intrinsic acidity could lead to an ionization process, decreasing fungal cell permeability. ...
Tópico(s): Synthesis and biological activity
2018 - Wiley | Chemical Biology & Drug Design
Produção Nacional
Revisado por pares
Bruna Pippi, Paula Reginatto, Gabriella da Rosa Monte Machado, Vanessa Zafaneli Bergamo, Daiane Flores Dalla Lana, Mário Lettieri Teixeira, Lucas Lopardi Franco, Ricardo José Alves, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefría,
Clioquinol is an 8-hydroxyquinoline derivative that was widely used from the 1950s to 1970s as an oral antiparasitic agent. In 1970, the oral forms were withdrawn from the market due to reports of toxicity, but topical formulations for antifungal treatment remained available. Thus, the purpose of this study was to evaluate the toxicity, anti-Candida and antidermatophyte activity and to determine pharmacodynamic characteristics of clioquinol and other 8-hydroxyquinoline derivatives (8-hydroxy-5-quinolinesulfonic ...
Tópico(s): Antifungal resistance and susceptibility
2017 - Oxford University Press | Medical Mycology
Produção Nacional
Revisado por pares
Alexandre Meneghello Fuentefría, Bruna Pippi, Daiane Flores Dalla Lana, K.K. Donato, Saulo Fernandes de Andrade,
Undeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal infections have significantly increased in recent decades, being highlighted as important causes of morbidity and mortality, particularly in immunocompromised patients. Five main antifungal classes are used: (i) azoles, (ii) echinocandins, (iii) polyenes, (iv) allylamines and (v) pyrimidine analogues. Moreover, the treatment of mycoses has several limitations, such as undesirable side effects, narrow activity spectrum, ...
Tópico(s): Plant Pathogens and Fungal Diseases
2017 - Oxford University Press | Letters in Applied Microbiology
Produção Nacional
Revisado por pares
Rachel Wykowski, Alexandre Meneghello Fuentefría, Saulo Fernandes de Andrade,
Clioquinol and nitroxoline, two drugs with numerous pharmacological properties fallen into disuse for many decades. The first was considered dangerous due to contraindications and the second mainly because was taken as ineffective, despite its known antibacterial activity. In the last decades, the advances in pharmaceutical chemistry, molecular biology, toxicology and genetics allowed to better understand the cellular action of these compounds, some toxicological issues and/or activity scopes. Thus, ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2022 - Springer Science+Business Media | Archives of Microbiology
Produção Nacional
Revisado por pares
Bruno Toson, Isadora Serraglio Fortes, Rafael Roesler, Saulo Fernandes de Andrade,
The serine/threonine kinase Akt is a major player in the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, and its modulation impacts multiple cellular processes such as growth, proliferation, and survival. Several abnormalities in this pathway have been documented over the years, and these alterations were shown to have great implications in tumorigenesis and resistance to chemotherapy. Thus, multiple Akt inhibitors have been developed and tested in adult ...
Tópico(s): Neuroblastoma Research and Treatments
2022 - Elsevier BV | Pharmacological Research
Produção Nacional
Revisado por pares
Angélica Rocha Joaquim, Mariana Pies Gionbelli, Grace Gosmann, Alexandre Meneghello Fuentefría, Marcela Silva Lopes, Saulo Fernandes de Andrade,
The search for new antimicrobials is imperative due to the emergent resistance of new microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines could be an interesting strategy to discover new agents. The 8-hydroxyquinoline derivatives nitroxoline and clioquinol are used to treat microbial infections; however, these drugs are underused, being available in few countries or limited to topical use. After years of few advances, in the last two decades, the potent activity ...
Tópico(s): Synthesis and biological activity
2021 - American Chemical Society | Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Elany Barbosa da Silva, Débora Assumpção Rocha, Isadora Serraglio Fortes, Wenqian Yang, Ludovica Monti, Jair L. Siqueira-Neto, Conor R. Caffrey, James H. McKerrow, Saulo Fernandes de Andrade, Rafaela Salgado Ferreira,
The cysteine proteases, cruzain and TbrCATL (rhodesain), are therapeutic targets for Chagas disease and Human African Trypanosomiasis, respectively. Among the known inhibitors for these proteases, we have described N4-benzyl-N2-phenylquinazoline-2,4-diamine (compound 7 in the original publication, 1a in this study), as a competitive cruzain inhibitor (Ki = 1.4 μM). Here, we describe the synthesis and biological evaluation of 22 analogs of 1a, containing modifications in the quinazoline core, and in the ...
Tópico(s): Synthesis and Biological Evaluation
2021 - American Chemical Society | Journal of Medicinal Chemistry
N.A. Al-eesa, Saulo Fernandes, Robert G. Hill, F.S.L. Wong, Urangua Jargalsaikhan, Syed M. Shahid,
The objective was to investigate the mechanical properties, fluoride release and apatite formation of resin based dental composites based on a fluoride containing Bioactive Glass (BG) with and without a silylating agent. A SiO2–P2O5–CaO–SrO–Na2O–CaF2 BG was synthesized by the melt quench route. This glass and a commercially available inert glass (IG) were incorporated into a light cured BisGMA-TEGMA resin. The composite resins were then evaluated in terms of their ability to form apatite by Fourier ...
Tópico(s): Orthodontics and Dentofacial Orthopedics
2021 - Elsevier BV | Dental Materials
Produção Nacional
Revisado por pares
Gabriella da Rosa Monte Machado, Denise Diedrich, Thaís Carine Ruaro, Aline Rigon Zimmer, Mário Lettieri Teixeira, Luís Flávio de Oliveira, Mickaël Jean, Pierre van de Weghe, Saulo Fernandes de Andrade, Simone Cristina Baggio Gnoatto, Alexandre Meneghello Fuentefría,
Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric ...
Tópico(s): Fungal Infections and Studies
2020 - Springer Nature | Brazilian Journal of Microbiology
Produção Nacional
Revisado por pares
Isabela Nascimento Borges, Rafael Mourão Carneiro, Rafael Bergo, Larissa Natany Almeida Martins, Enrico A. Colosimo, Carolina Oliveira, Saulo Fernandes Saturnino, Marcus Vinícius Melo de Andrade, Cecilia Gómez Ravetti, Vandack Nobre,
Abstract Background The rational use of antibiotics is one of the main strategies to limit the development of bacterial resistance. We therefore sought to evaluate the effectiveness of a C-reactive protein-based protocol in reducing antibiotic treatment time in critically ill patients. Methods A randomized, open-label, controlled clinical trial conducted in two intensive care units of a university hospital in Brazil. Critically ill infected adult patients were randomly allocated to (i) intervention ...
Tópico(s): Nosocomial Infections in ICU
2020 - BioMed Central | Critical Care
Produção Nacional
Revisado por pares
Bruna Pippi, Angélica Rocha Joaquim, William Lopes, Gabriella da Rosa Monte Machado, Vanessa Zafaneli Bergamo, Laura Giuliani, Maxwel Adriano Abegg, Letícia Cruz, Marilene Henning Vainstein, Alexandre Meneghello Fuentefría, Saulo Fernandes de Andrade,
The purpose of this study was to uncover insights into the mechanism of action of the 8-hydroxyquinoline derivatives PH151 and PH153. In addition, with the future perspective of developing a topical drug for the treatment of candidiasis and dermatophytosis, the antifungal activity of a nanoemulsion formulation containing the most active compound (PH151) is also presented here.Sorbitol protection assay and scanning electron microscopy indicate that the 8-hydroxyquinoline derivatives act on the cell ...
Tópico(s): Nail Diseases and Treatments
2019 - Oxford University Press | Journal of Applied Microbiology
Produção Nacional
Revisado por pares
Glaécia A. N. Pereira, Elany B. da Silva, Saulo Fehelberg Pinto Braga, Paulo Gaio Leite, Luan Carvalho Martins, Rafael P. Vieira, Wai Tuck Soh, Filipe Silva Villela, Francielly Morais Rodrigues da Costa, Debalina Ray, Saulo Fernandes de Andrade, Hans Brandstetter, Renata Barbosa de Oliveira, Conor R. Caffrey, Fabiana S. Machado, Rafaela Salgado Ferreira,
Chagas disease, Human African Trypanosomiasis, and schistosomiasis are neglected parasitic diseases for which new treatments are urgently needed. To identify new chemical leads, we screened the 400 compounds of the Open Access Malaria Box against the cysteine proteases, cruzain (Trypanosoma cruzi), rhodesain (Trypanosoma brucei) and SmCB1 (Schistosoma mansoni), which are therapeutic targets for these diseases. Whereas just three hits were observed for SmCB1, 70 compounds inhibited cruzain or rhodesain ...
Tópico(s): Malaria Research and Control
2019 - Elsevier BV | European Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Laurita Boff, Jennifer Munkert, Flaviano Melo Ottoni, Naira Fernanda Zanchett Schneider, Gabriela Silva Ramos, Wolfgang Kreis, Saulo Fernandes de Andrade, José Dias de Souza Filho, Fernão Castro Braga, Ricardo José Alves, Rodrigo Maia de Pádua, Cláudia Maria Oliveira Simões,
In recent years, new therapeutic possibilities were proposed for cardiac glycosides traditionally used to treat heart diseases, such as anticancer and antiviral activities. In this sense, this work aimed to synthesize the readily accessible 3β-azido-3-deoxydigitoxigenin (5) from digitoxigenin (1). Two new series of compounds were obtained from derivative (5): (i) O-glycosyl trizols through click chemistry with propargyl glycosides; and (ii) compounds substituted in the alpha carbonyl position with different ...
Tópico(s): Phytochemical compounds biological activities
2019 - Elsevier BV | European Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Bruna Pippi, William Lopes, Paula Reginatto, Fernanda Émili Klein Silva, Angélica Rocha Joaquim, Ricardo José Alves, Gustavo P. Silveira, Marilene Henning Vainstein, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefría,
The 8-hydroxyquinoline core is a privileged scaffold for drug design explored to afford novel derivatives endowed with biological activity. Our research aimed at clarifying the antifungal mechanism of action of clioquinol, 8-hydroxy-5-quinolinesulfonic acid, and 8-hydroxy-7-iodo-5-quinolinesulfonic acid (three 8-hydroxyquinoline derivatives). The antifungal mode of action of these derivatives on
Tópico(s): Bioactive Compounds and Antitumor Agents
2018 - Elsevier BV | Saudi Pharmaceutical Journal
Produção Nacional
Revisado por pares
Fernando Torres, Guilherme Arraché Gonçalves, Kenia L. Vanzolini, Aloir A. Merlo, Bruna Gauer, Maribete Holzschuh, Saulo Fernandes de Andrade, Maristela Cabral da Silva Piedade, Solange Cristina García, Ivone Carvalho, Gilsane Lino von Poser, Daniel Fábio Kawano, Vera Lucia Eifler‐Lima, Quézia B. Cass,
Coumarins are a large class of compounds that display a range of interesting biological properties, being considered privileged structures because of the ability of their 2H-chromen-2-one nuclei to bind to multiple pharmacological targets.We hypothesized that the linkage of a second pharmacophore nucleus to the 2H-chromen-2-one core, the 1,2,3-triazole moiety, would entail more selective and pharmacologically active coumarins.Therefore, we describe the synthesis of fourteen 4-methylcoumarins/1,4- ...
Tópico(s): Synthesis and biological activity
2016 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Produção Nacional
Revisado por pares
Leonardo de Sousa Fortes, Maria Elisa Caputo Ferreira, Saulo Fernandes Melo de Oliveira, Edílson Serpeloni Cyrino, Sebastião Sousa Almeida,
The objective of this study was to develop a socio-sports model of disordered eating (DE) in Brazilian male athletes. Three hundred and twenty one athletes over 12 years of age from 18 different sports modalities were investigated. The Eating Attitudes Test (EAT-26) was applied to evaluate DE. The Body Shape Questionnaire (BSQ) was used to evaluate athlete dissatisfaction with body fat levels. The Muscularity Concern subscale of the Drive for Muscularity Scale (DMS) was used to evaluate athlete dissatisfaction ...
Tópico(s): Adventure Sports and Sensation Seeking
2015 - Elsevier BV | Appetite
Produção Nacional
Revisado por pares
Ricardo Pereira Rodrigues, Saulo Fernandes de Andrade, Susimaire P. Mantoani, Vera Lucia Eifler‐Lima, Vinícius Barreto da Silva, Daniel Fábio Kawano,
Advances in, and dissemination of, computer technologies in the field of drug research now enable the use of molecular modeling tools to teach important concepts of drug design to chemistry and pharmacy students. A series of computer laboratories is described to introduce undergraduate students to commonly adopted in silico drug design methods, such as molecular geometry optimization, pharmacophore modeling, protein–ligand docking simulations, homology modeling, virtual screening, and pharmacokinetics/ ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2015 - American Chemical Society | Journal of Chemical Education
Produção Nacional
Revisado por pares
Thiago Belarmino de Souza, Paulo Otávio Botelho Raimundo, Saulo Fernandes de Andrade, Taciane Maíra Magalhães Hipólito, Naiara Chaves Silva, Amanda Latércia Tranches Dias, Masaharu Ikegaki, Raíssa Prado Rocha, Luiz Felipe Leomil Coelho, Márcia Paranho Veloso, Diogo Teixeira Carvalho, Danielle Ferreira Dias,
A new series of 1,2,3-triazole eugenol glucosides were synthesized. The new compound structures were confirmed by MS, 1H NMR and 13C NMR. All of the synthesized compounds were screened for antimicrobial and cytotoxic activity. Five compounds exerted significant activity against the Gram-negative bacteria Salmonella typhimurium with low IC50 values (49.73–68.53 μΜ), and seven compounds were active against the Gram-positive bacteria Micrococcus luteus (42.89–210.94 μM). In vitro cytotoxicity on mouse ...
Tópico(s): Fungal Plant Pathogen Control
2015 - Elsevier BV | Carbohydrate Research
Produção Nacional
Revisado por pares
Patrícia Frasson Corbelini, Fabrício Figueiró, Gustavo Machado das Neves, Saulo Fernandes de Andrade, Daniel Fábio Kawano, Ana Oliveira Battastini, Vera Lucia Eifler‐Lima,
Ecto-5’-nucleotidase (ecto-5’-NT, 5’-NT, eN, CD73) is a membrane ectoenzyme that is primarily responsible for the extracellular production of adenosine from AMP. Ecto-5'-NT is overexpressed in various types of cancer cells, leading to elevated concentrations of adenosine in the tumour microenvironment. Adenosine has also been found to be important in cancer pathogenesis, showing strong immunosuppressive effects over antitumour T cells and macrophages and promoting neovascularization and cell adherence. ...
Tópico(s): Chemical Reactions and Isotopes
2015 - Bentham Science Publishers | Current Medicinal Chemistry
Produção Nacional
Revisado por pares
Tatiane Carla Teles de Moura, Manoel Cunha Costa, Saulo Fernandes Melo de Oliveira, Marcos Barbosa Júnior, Raphael Mendes Ritti‐Dias, Marcos André Moura dos Santos,
The aim of this study was to examine the relationship between anthropometric variables, body composition and propulsive force in swimmers aged 9-17 years. Anthropometric characteristics (body height and mass, sitting height, arm span, arm muscle area and body composition) and the propulsive force of the arm (tethered swimming test) were evaluated in 56 competitive male swimmers. Tanner's stages of genital maturation (P1-5) were used. The data analysis included correlations and multiple linear regression. ...
Tópico(s): Sports injuries and prevention
2014 - De Gruyter Open | Journal of Human Kinetics
Produção Nacional
Revisado por pares
Fernando Torres, Natália Brucker, Saulo Fernandes de Andrade, Daniel Fábio Kawano, Solange Cristina García, Gilsane Lino von Poser, Vera Lucia Eifler‐Lima,
Coumarins are considered to be privileged structures due to their broad range of biological properties, including anticoagulant, anti-neurodegenerative, antioxidant, anticancer and antimicrobial activities. These interesting properties of coumarins can be ascribed to the chemical attributes of the 2H-chromen-2-one core; its aromatic ring can establish a series of hydrophobic, π-π, CH-π and cation-π interactions, and the two oxygen atoms in the lactone ring may hydrogen-bond to a series of amino ...
Tópico(s): Synthesis and biological activity
2014 - Bentham Science Publishers | Current Topics in Medicinal Chemistry
Produção Nacional
Revisado por pares
Adalberto Veronese da Costa, Manoel da Cunha Costa, Saulo Fernandes Melo de Oliveira, Albuquerque, Guimarães, Tiago M. Barbosa,
To validate an equation to estimate the maximal oxygen consumption (VO2max) of nonexpert adult swimmers.Participants were 22 nonexpert swimmers, male, aged between 18 and 30 years (age: 23.1 ± 3:59 years; body mass: 73.6 ± 7:39 kg; height 176.6 ± 5.53 cm; and body fat percentage: 15.9% ± 4.39%), divided into two subgroups: G1 - eleven swimmers for the VO2max oximetry and modeling of the equation; and G2 - eleven swimmers for application of the equation modeled on G1 and verification of their validation. The test ...
Tópico(s): High Altitude and Hypoxia
2013 - Dove Medical Press | Open Access Journal of Sports Medicine
Produção Nacional
Revisado por pares
Saulo Fernandes Saturnino, Roberta O Prado, José Renan Cunha-Melo, Marcus Vinícius Melo de Andrade,
Abstract Background The study of the endotoxin tolerance phenomenon in light of the recently defined roles of mast cells and toll-like receptors as essential components of the innate immune response and as orchestrators of acquired immunity may reveal potentially useful mechanisms of immunomodulation of infectious and allergic inflammatory responses, such as sepsis or asthma. Here we evaluated the phenomenon of direct tolerance of endotoxins, as well as the induction of cross-tolerance and synergism ...
Tópico(s): Immune Response and Inflammation
2010 - BioMed Central | BMC Infectious Diseases
Produção Nacional
Revisado por pares
Gustavo Augusto Fernandes Correia, Carlos Gilberto de Freitas-Junior, Hugo Alvares Lira, Saulo Fernandes Melo de Oliveira, Wlaldemir Roberto dos Santos, Camilla Karen de Freitas Bezerra da Silva, Paulo Henrique Vaz Silva, Pedro Pinheiro Paes,
Este estudo investigou o efeito do treinamento pliométrico (TP) no salto vertical em atletas jovens de basquete. Participaram 39 atletas, divididos em dois grupos experimentais (masculino - GEM e feminino - GEF) e dois grupos controle (masculino - GCM e feminino - GCF). O aplicativo My Jump quantificou a altura do salto a partir do tempo de voo. Para análise dos dados utilizou-se anova de medidas repetidas, tamanho de efeito de Cohen (TE) e a inferência baseada na magnitude, com nível de significância (p≤ 0, ...
Tópico(s): Physical Education and Gymnastics
2020 - UNIVERSIDADE ESTADUAL DE MARINGÁ | Journal of Physical Education
Produção Nacional
Revisado por pares
Tiago Amador, Saulo Fernandes Saturnino, Adriano Veloso, Nívio Ziviani,
The aim of this study is to build machine learning models to predict severe complications using administrative and clinical elements that are collected immediately after patient admission to the intensive care unit (ICU). Risk models are of increasing importance in the ICU setting. However, they generally present the black-box issue because they do not provide meaningful information about the logic involved in patient-specific predictions. Fortunately, effective algorithms exist for explaining black- ...
Tópico(s): Artificial Intelligence in Healthcare and Education
2022 - Elsevier BV | Artificial Intelligence in Medicine
Produção Nacional
Revisado por pares
Bárbara da Costa, Bruna Pippi, Taís Fernanda Andrzejewski Kaminski, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefría,
Summary Background Dermatophytoses are the most frequent fungal infections worldwide and there have been described clinical resistance to the commonly used antifungals. Clioquinol is an antimicrobial that had the oral formulations withdrawn from the market in the 70s due to the report of neurotoxicity and recently has been considered as an effective alternative for the treatment of dermatophytosis. Objectives To evaluate the effect of the double and triple association between clioquinol with terbinafine ...
Tópico(s): Antifungal resistance and susceptibility
2020 - Wiley | Mycoses
Produção Nacional
Revisado por pares
Daiane Flores Dalla Lana, Laura Giuliani, Jéssica Brandão Reolon, William Lopes, Marilene Henning Vainstein, Letícia Jacobi Danielli, Vanessa Zafaneli Bergamo, Bruna Pippi, Miriam Anders Apel, Mário Lettieri Teixeira, Luís Flávio Souza de Oliveira, Michel Mansur Machado, Saulo Fernandes de Andrade, Marcus M. Sá, Misael Ferreira, Laiéli S. Munaretto, Letícia Cruz, Gustavo P. Silveira, Edilma Elayne, Alexandre Meneghello Fuentefría,
Abstract We report the antifungal and antichemotactic activities of a series of allylic thiocyanates with low toxicity. We also show improved antifungal activity of the most promising compound when used in a nanoemulsion (NE). The 4‐chlorophenyl‐substituted allylic thiocyanate (compound 11 ) exhibited a broad spectrum of antifungal activity and showed antichemotactic effects with 100% reduction in leucocyte migration. Minimal inhibitory concentrations ranged from 25 to 50 μg mL −1 , and the mechanism of ...
Tópico(s): Antimicrobial agents and applications
2018 - Wiley | ChemistrySelect
Produção Nacional
Revisado por pares
Bruna Pippi, Gabriella da Rosa Monte Machado, Vanessa Zafaneli Bergamo, Ricardo José Alves, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefría,
Candida biofilm infections are frequently linked to the use of biomaterials and are of clinical significance because they are commonly resistant to antifungals. Clioquinol is an antiseptic drug and is effective against multidrug-resistant Candida. We investigated the effect of clioquinol and two other 8-hydroxyquinoline derivatives on Candida biofilm.The ability to inhibit biofilm formation, inhibit preformed biofilm and remove established biofilms was evaluated using in vitro assays on microtitre ...
Tópico(s): Cystic Fibrosis Research Advances
2018 - Microbiology Society | Journal of Medical Microbiology