Angela Stefanachi, Orazio Nicolotti, Francesco Leonetti, Saverio Cellamare, Francesco Campagna, Marı́a Isabel Loza, José Brea, Fernando Mazza, E. Gavuzzo, Angelo Carotti,
A number of 1,3-dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines were prepared and evaluated as ligands of recombinant human adenosine receptors (hARs). Several 1,3-dipropyl derivatives endowed with nanomolar binding affinity at hA2B receptors, but poor selectivity over hA2A, hA1 and hA3 AR subtypes were identified. A comparison with the corresponding 7-OH- and 7,9-unsubstituted-deazaxanthines revealed that 9-OH-9-deazaxanthines are more potent hA2B ligands with lower partition coefficients and higher ...
Tópico(s): Vagus Nerve Stimulation Research
2008 - Elsevier BV | Bioorganic & Medicinal Chemistry
Angela Stefanachi, Nina Hanke, Leonardo Pisani, Francesco Leonetti, Orazio Nicolotti, Marco Catto, Saverio Cellamare, Rolf W. Hartmann, Angelo Carotti,
Diseases triggered by an abnormally high level of cortisol (hypercortisolism), such as the Cushing's and metabolic syndromes, could be successfully tackled by inhibitors of CYP11B1, a steroidal cytochrome P450 enzyme that catalyzes the last hydroxylation step of the cortisol biosynthesis. Structural optimization of 7-(benzyloxy)-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one 2, a selective aromatase inhibitor, afforded the 4-(1H-imidazol-1-ylmethyl)-7-{[3-(trifluoromethoxy)benzyl]oxy}-2H-chromen-2-one ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2014 - Elsevier BV | European Journal of Medicinal Chemistry
Orazio Nicolotti, Marco Catto, Ilenia Giangreco, M. Barletta, Francesco Leonetti, Angela Stefanachi, Leonardo Pisani, Saverio Cellamare, Paolo Tortorella, Fulvio Loiodice, Angelo Carotti,
Matrix metalloproteinases (MMPs) are attractive biological targets that play a key role in many physiopathological processes such as degradation of extracellular matrix proteins, release and cleavage of cell-surface receptors, tumour progression, homeostatic regulation and innate immunity. A series of 5-hydroxy, 5-substituted pyrimidine-2,4,6-triones were rationally designed, prepared and tested as inhibitors of gelatinases MMP-2 and MMP-9 and collagenase MMP-8. On one side, the presence of the 5- ...
Tópico(s): Peptidase Inhibition and Analysis
2012 - Elsevier BV | European Journal of Medicinal Chemistry
Leonardo Pisani, Marco Catto, Ilenia Giangreco, Francesco Leonetti, Orazio Nicolotti, Angela Stefanachi, Saverio Cellamare, Angelo Carotti,
Abstract A large series of substituted coumarins linked through an appropriate spacer to 3‐hydroxy‐ N , N ‐dimethylanilino or 3‐hydroxy‐ N , N , N ‐trialkylbenzaminium moieties were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The highest AChE inhibitory potency in the 3‐hydroxy‐ N , N ‐dimethylanilino series was observed with a 6,7‐dimethoxy‐3‐substituted coumarin derivative, which, along with an outstanding affinity (IC 50 =0.236 n M ) exhibits excellent ...
Tópico(s): Synthesis and biological activity
2010 - Wiley | ChemMedChem
Ruggero De Paulis, Daniele Maselli, Andrea Salica, Stefania Leonetti, Lorenzo Guerrieri Wolf, Luca Weltert, Saverio Nardella, Alessandro Bellisario,
OBJECTIVESSurgical treatment of Barlow's disease is usually demanding. In a sub-population of Barlow patients with bileaflets prolapse and central regurgitant jet, we performed mitral repair using only a semi-rigid annuloplasty band. Stress echocardiography follow-up was evaluated.
Tópico(s): Cardiovascular Function and Risk Factors
2015 - Oxford University Press | Interactive Cardiovascular and Thoracic Surgery
Marco Catto, Leonardo Pisani, Francesco Leonetti, Orazio Nicolotti, Paolo Pesce, Angela Stefanachi, Saverio Cellamare, Angelo Carotti,
Acetylcholinesterase inhibitors (AChEIs) are currently the drugs of choice, although only symptomatic and palliative, for the treatment of Alzheimer’s disease (AD). Donepezil is one of most used AChEIs in AD therapy, acting as a dual binding site, reversible inhibitor of AChE with high selectivity over butyrylcholinesterase (BChE). Through a combined target- and ligand-based approach, a series of coumarin alkylamines matching the structural determinants of donepezil were designed and prepared. 6,7- ...
Tópico(s): Chemical synthesis and alkaloids
2012 - Elsevier BV | Bioorganic & Medicinal Chemistry
R.Z. Pellicani, Angela Stefanachi, Mauro Niso, Angelo Carotti, Francesco Leonetti, Orazio Nicolotti, Roberto Perrone, Francesco Berardi, Saverio Cellamare, Nicola Antonio Colabufo,
The multifactorial nature of chemotherapy failure in controlling cancer is often associated with the occurrence of multidrug resistance (MDR), a phenomenon likely related to the increased expression of members of the ATP binding cassette (ABC) transporter superfamily. In this respect, the most extensively characterized MDR transporters include ABCB1 (also known as MDR1 or P-glycoprotein) and ABCC1 (also known as MRP1) whose inhibition remains a priority to circumvent drug resistance. Herein, we report ...
Tópico(s): HIV/AIDS drug development and treatment
2011 - American Chemical Society | Journal of Medicinal Chemistry
Piero Tardia, Angela Stefanachi, Mauro Niso, Diana A. Stolfa, Giuseppe Felice Mangiatordi, Domenico Alberga, Orazio Nicolotti, Gianluca Lattanzi, Angelo Carotti, Francesco Leonetti, Roberto Perrone, Francesco Berardi, Amalia Azzariti, Nicola Antonio Colabufo, Saverio Cellamare,
One of the principal reasons for the chemotherapy failure is the overexpression of drug efflux pumps, ABCB1 (also known as MDR1 or P-gp) and ABCC1 (also known as MRP1), whose inhibition remains a priority to circumvent drug resistance. We have recently shown a clear trend between lipophilicity and P-glycoprotein inhibitory activity for a class of galloyl-based modulators targeting P-glycoprotein and MRP1. Herein we report a new series of polymethoxy benzamides, whose lipophilicity was modulated through ...
Tópico(s): HIV/AIDS drug development and treatment
2014 - American Chemical Society | Journal of Medicinal Chemistry
Francesco Leonetti, Carmelida Capaldi, Leonardo Pisani, Orazio Nicolotti, Giovanni Muncipinto, Angela Stefanachi, Saverio Cellamare, Carla Caccia, Angelo Carotti,
Safinamide, (S)-N2-{4-[(3-fluorobenzyl)oxy]benzyl}alaninamide methanesulfonate, which is in phase III clinical trials as an anti-Parkinson drug, and a library of alkanamidic analogues were prepared through an expeditious solid-phase synthesis and evaluated for their monoamine oxidase B (MAO-B) and monoamine oxidase A (MAO-A) inhibitory activity and selectivity. (S)-3-Chlorobenzyloxyalaninamide (8) and (S)-3-chlorobenzyloxyserinamide (13) derivatives proved to be more potent MAO-B inhibitors than safinamide ( ...
Tópico(s): Synthesis and Biological Evaluation
2007 - American Chemical Society | Journal of Medicinal Chemistry
Orazio Nicolotti, Marino Convertino, Francesco Leonetti, Marco Catto, Saverio Cellamare, Angelo Carotti,
Since Hansch's extra thermodynamic multi-parameter approach, originally coined as Linear Free Energy Relationship, great efforts in medicinal chemistry have been made to properly estimate the binding free energy. Despite the often small amount, its value is however very critical in determining a successful binding. As a result, its correct estimation may provide a guide for a prospective rational drug design. The calculation of the absolute binding free energies is however a very challenging task ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
2012 - Bentham Science Publishers | Mini-Reviews in Medicinal Chemistry
Angela Stefanachi, Francesco Leonetti, Orazio Nicolotti, Marco Catto, Leonardo Pisani, Saverio Cellamare, Claudia Altomare, Alessandra Carotti,
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by the Philadelphia-positive chromosome deriving from a translocation between chromosomes 22 and 9. The oncogenic product of this aberrant chromosome is the constitutively active tyrosine kinase BCR-ABL that is responsible for leukemic cell growth, proliferation and survival driven by the dysregulation of a large array of signal transduction pathways. Inhibition of BCRABL with tyrosine kinase inhibitors proved to be an efficient ...
Tópico(s): Synthesis of Tetrazole Derivatives
2012 - Bentham Science Publishers | Current Cancer Drug Targets
Giuseppe Felice Mangiatordi, Domenico Alberga, Cosimo Altomare, Angelo Carotti, Marco Catto, Saverio Cellamare, Domenico Gadaleta, Gianluca Lattanzi, Francesco Leonetti, Leonardo Pisani, Angela Stefanachi, Daniela Trisciuzzi, Orazio Nicolotti,
Computational methods have advanced toxicology towards the development of target-specific models based on a clear cause-effect rationale. However, the predictive potential of these models presents strengths and weaknesses. On the good side, in silico models are valuable cheap alternatives to in vitro and in vivo experiments. On the other, the unconscious use of in silico methods can mislead end-users with elusive results. The focus of this review is on the basic scientific and regulatory recommendations ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2016 - Wiley | Molecular Informatics
María Majellaro, Angela Stefanachi, Piero Tardia, Chiara Vicenti, Angelina Boccarelli, Alessandra Pannunzio, Federica Campanella, Mauro Coluccia, Nunzio Denora, Francesco Leonetti, Modesto de Candia, Cosimo Altomare, Saverio Cellamare,
A number of trimethoxybenzoic acid anilides, previously studied as permeability glycoprotein (P-gp) modulators, were screened with the aim of identifying new anticancer agents. One of these compounds, which showed antiproliferative activity against resistant MCF-7 cell line, was selected as the hit structure. Replacement of the trimethoxybenzoyl moiety with a nicotinoyl group, in order to overcome solubility issues, led to a new series of N-biphenyl nicotinoyl anilides, among which a nitro derivative, ...
Tópico(s): Metal complexes synthesis and properties
2017 - Wiley | ChemMedChem
Francesco Leonetti, Angela Stefanachi, Orazio Nicolotti, Marco Catto, Leonardo Pisani, Saverio Cellamare, Alessandra Carotti,
Chronic myeloid leukemia (CML) is a myeloproliferative disease originating from a constitutively active tyrosine kinase, called BCR-ABL, expressed by an oncogene resulting from a reciprocal translocation between chromosome 9 and chromosome 22, coded as (t[9,22][q34;q11]). Inhibition of BCR-ABL with tyrosine kinase inhibitors (TKI) proved to be an efficient targeted therapy of Philadelphia-positive (Ph+) CML in the chronic phase. This review mainly addresses the synthetic pathways and process chemistry ...
Tópico(s): Click Chemistry and Applications
2011 - Bentham Science Publishers | Current Medicinal Chemistry
Rosa Maria Iacobazzi, Annalisa Cutrignelli, Angela Stefanachi, Letizia Porcelli, Angela Lopedota, R. Fonte, Antonio Lopalco, Simona Serratì, Valentino Laquintana, Nicola Silvestris, Massimo Franco, Saverio Cellamare, Francesco Leonetti, Amalia Azzariti, Nunzio Denora,
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with poor outcomes largely due to its unique microenvironment, which is responsible for the low response to drugs and drug-resistance phenomena. This clinical need led us to explore new therapeutic approaches for systemic PDAC treatment by the utilization of two newly synthesized biphenylnicotinamide derivatives, PTA73 and PTA34, with remarkable antitumor activity in an in vitro PDAC model. Given their poor water ...
Tópico(s): Cancer therapeutics and mechanisms
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Francesco Leonetti, Giovanni Muncipinto, Angela Stefanachi, Orazio Nicolotti, Saverio Cellamare, Marco Catto, Leonardo Pisani, Giovanni Pellegrino, Angelo Carotti,
Matrix metalloproteinases (MMPs), a class of zinc-enzymes over-activated in many pathologies, such as arthritis and cancer, can be efficiently inhibited by a variety of molecules bearing zinc-binding groups (ZBGs). The hydroxamic acid moiety represents one of the most potent and widely exploited ZBG but the poor target selectivity and in vivo toxicity have tempered the initial enthusiasm for this class of potential therapeutics. These drawbacks might be circumvented, at least in part, by increasing ...
Tópico(s): Signaling Pathways in Disease
2012 - Elsevier BV | Tetrahedron Letters
Valentina Leo, Angela Stefanachi, Carmela Nacci, Francesco Leonetti, Modesto de Candia, Angelo Carotti, Cosimo Altomare, Monica Montagnani, Saverio Cellamare,
The aim of this work is to investigate whether and how two newly synthesized 3,4,5-trimethoxygalloyl-containing compounds 1 and 3 interfere with the mitogen-activated protein kinase (MAPK) signalling pathways involved in several pathological events, ranging from inflammatory diseases to cancer.The effects on the phosphorylation of MAP kinases (c-Jun N-terminal kinases (JNKs), p38) and activation of nuclear factor-kappa B (NF-κB) pathways of 1 and its 1H-indazole-containing analogue 3, compared with ...
Tópico(s): Inflammatory mediators and NSAID effects
2015 - Oxford University Press | Journal of Pharmacy and Pharmacology
Angela Stefanachi, Giuseppe Felice Mangiatordi, Piero Tardia, Domenico Alberga, Francesco Leonetti, Mauro Niso, Nicola Antonio Colabufo, Carlo Adamo, Orazio Nicolotti, Saverio Cellamare,
In a recent investigation carried out on a panel of trimethoxybenzanilides, we showed that the formation of an intramolecular hydrogen bond is a key element for tuning P-gp inhibitory activity. In this study, we designed new structurally simplified trimethoxy benzamides (5-17, Table ) with the aim to uncover the minimal molecular requirements needed for P-gp inhibition. The new prepared smaller-sized compounds exhibited IC50 in the low micromolar range. The combined use of NMR and DFT studies suggested ...
Tópico(s): Chemical Synthesis and Analysis
2016 - Wiley | Chemical Biology & Drug Design
Gianluca Santise, Saverio Nardella, Stefania Leonetti, Dario Buioni, Bindo Missiroli, Emanuele Di Marzio, Daniele Maselli, Darren Mylotte, Nicolò Piazza, Thomas Modine, Federico De Marco, Andrea Garatti, Luca Testa, Francesco Bedogni,
Tópico(s): Cardiac Structural Anomalies and Repair
2016 - European Association of Percutaneous Cardiovascular Interventions | EuroIntervention
Francesco Perrone, Maria Carmela Piccirillo, Paolo A. Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco‐Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, María Lorenza Muiesan, Miriam Lichtner, Carlo Calzetti, Nicola Duccio Salerno, Luigi Atripaldi, Marco Cascella, Massimo Costantini, Giovanni Dolci, Nicola Facciolongo, Fiorentino Fraganza, Marco Massari, Vincenzo Montesarchio, Cristina Mussini, Emanuele Alberto Negri, Gerardo Botti, Claudia Cardone, Piera Gargiulo, Adriano Gravina, Clorinda Schettino, Laura Arenare, Paolo Chiodini, Ciro Gallo, Francesco Perrone, Maria Carmela Piccirillo, Clorinda Schettino, Adriano Gravina, Piera Gargiulo, Claudia Cardone, Laura Arenare, Paolo A. Ascierto, Maria Grazia Vitale, Claudia Trojaniello, Marco Palla, Attilio Antonio Montano Bianchi, Gerardo Botti, Gianfranco De Feo, Leonardo Miscio, Ciro Gallo, Paolo Chiodini, Laurenzia Ferraris, Massimiliano M. Marrocco‐Trischitta, M. Froldi, Lorenzo Menicanti, Maria Teresa Cuppone, Giulia Gobbo, Chiara Baldessari, Vincenzo Valenti, Serenella Castelvecchio, Federica Poli, Francesca Giacomazzi, Rosangela Piccinni, Maria Laura Annnunziata, Andrea Biondi, Cecilia Bussolari, Manuel Giovanni Mazzoleni, Andrea Giachi, Annalisa Filtz, Arianna Manini, Enrico Poletti, Federico Masserini, Francesco Conforti, Gianfranco Gaudiano, Vittoria Favero, A. Moroni, Tommaso Viva, Fabiana Fancoli, Davide Ferrari, Dario Niro, Marco Resta, Andrea Ballotta, Marco Poli, Marco Ranucci, Diego Ripamonti, Francesca Binda, Alessandra Tebaldi, Giuseppe Gritti, L. Pasulo, Leonardo Gaglio, Roberto Del Fabbro, Leonardo Alborghetti, Paolo Bonfanti, Nicola Squillace, Giulia Giustinetti, Paola Columpsi, Marina Elena Cazzaniga, Serena Capici, Luca Sala, Riccardo Di Sciacca, Giacomo Mosca, Maria Rosa Pirozzi, Francesco Castelli, María Lorenza Muiesan, Franco Franceschini, Aldo M. Roccaro, Massimo Salvetti, Anna Paini, Luciano Corda, Chiara Ricci, Lina Rachele Tomasoni, Paola Nasta, Silvia Lorenzotti, Silvia Odolini, Emanuele Focà, Eugenia Quirós-Roldán, Marco Metra, Stefano Maria Magrini, Paolo Borghetti, Nicola Latronico, Simone Piva, Matteo Filippini, Francesco Zuccalà, Sergio Cattaneo, Francesco Scolari, Nicola Bossini, Mario Gaggiotti, Martina Properzi, Miriam Lichtner, Cosmo Del Borgo, Raffaella Marocco, Valeria Belvisi, Tiziana Tieghi, Margherita De Masi, Paola Zuccalà, Paolo Fabietti, Angelo Vetica, V. S. Mercurio, Anna Carraro, Laura Fondaco, Blerta Kertusha, Ambrogio Curtolo, Emanuela Del Giudice, Riccardo Lubrano, Maria Gioconda Zotti, Antonella Puorto, Marcello Ciuffreda, Antonella Sarni, Gabriella Monteforte, Domenico M. Romeo, Emanuela Viola, C. Damiani, Antonietta Barone, Barbara Mantovani, Daniela Di Sanzo, Vincenzo Gentili, Massimo Carletti, Massimo Aiuti, Andrea Gallo, Piero Giuseppe Meliante, Salvatore Martellucci, Oliviero Riggio, Vincenzo Cardinale, Lorenzo Ridola, Maria Consiglia Bragazzi, Stefania Gioia, Emiliano Valenzi, Camilla Graziosi, Niccolò Bina, Martina Fasolo, Silvano Ricci, Maria Teresa Gioacchini, Antonella Lucci, Luisella Corso, Daniela Tornese, Parni Nijhawan, Francesco Equitani, Carmine Cosentino, Marcello Palladino, Frida Leonetti, Gaetano Leto, Camillo Gnessi, Giuseppe Campagna, Roberto Cesareo, Francesca Marrocco, Giuseppe Straface, Alessandra Mecozzi, Lidia Di Cerbo, Valentina Isgrò, Sergio Parrocchia, Giuseppe Visconti, Giorgio Casati, Carlo Calzetti, Alarico Ariani, Lorenzo Donghi, Nicola Duccio Salerno, Evelina Tacconelli, M. Bertoldi, Paolo Cattaneo, Lorenza Lambertenghi, Leonardo Pereira Motta, Luca Omega, Giovanni Albano, Roberto Parrella, Fiorentino Fraganza, Luigi Atripaldi, Vincenzo Montesarchio, Francesco Scarano, Annunziata De Rosa, Amalia Buglione, Sabrina Lavoretano, Gianfranco Gaglione, Mario De Marco, Vincenzo Sangiovanni, Francesco Maria Fusco, Rosaria Viglietti, Elio Manzillo, Carolina Rescigno, Raffaella Pisapia, Giulia Plamieri, Alberto Enrico Maraolo, Giosuè Calabria, Mario Catalano, Giuseppe Fiorentino, Anna Annunziata, Giorgio Emanuele Polistina, Pasquale Imitazione, Mariano Mollica, Vincenzo Esposito, Maurizio D’Abraccio, Rodolfo Punzi, Vincenzo Bianco, Costanza Sbreglia, Rosa Fontana Del Vecchio, Alessandro Bordonali, Antonina Franco, Carlo Salvarani, Marco Massari, Giovanni Dolci, Pierpaolo Salsi, Giuseppe Virzì, Ornella Calderone, Alfredo Molteni, Silvia Gennarini, Umberto Gnudi, Maria Anastasia Ricci, Giancarlo Titolo, Giulio Mensi, Pietro Vuotto, Beatrice Gasperini, Mauro Mancini, Zeno Pasquini, P. Spanu, Stefano Clementi, Simona Pierini, Daniela Bokor, Davide Gori, Morena Ciofetti, Marina Caimi, L. Bettazzi, E. Allevi, Silvia Furiani, Chiara Capitanio, Bernardino Mastropasqua, Claudio Fara, Grazia Pulitanò, Jun Matsuno, Francesca Porta, Viola Dolfini, Nebiat Balei Beyene, Michela Bezzi, Mauro Novali, Pierluigi Viale, Sara Tedeschi, Renato Pascale, Raffaele Bruno, Di Filippo A, Michele Sachs, Tiberio Oggionni, M. Di Stefano, Caterina Mengoli, Cesarina Facchini, De Nardo Daniele, Gabriele Frausini, Luciano Mucci, Silvia Tedesco, Rita Girolimetti, Elena Manfredini, Anna Maria Di Carlo, Emma Espinosa, Donatella Dennetta, Andrea Ticinesi, Tiziana Meschi, Antonio Nouvenne,
Abstract Background Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients. Methods A multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study the effect of tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints, a priori expected rates being 20 and 35%, respectively). A further prospective cohort of patients, consecutively enrolled ...
BioMed Central
Mari Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Gita A. Pathak, Shea J. Andrews, Masahiro Kanai, Kumar Veerapen, Israel Fernández‐Cadenas, Eva C. Schulte, Pasquale Striano, M. Marttila, Camelia C. Minică, Eirini Marouli, Mohd Anisul Karim, Frank R. Wendt, Jeanne E. Savage, Laura Sloofman, Guillaume Butler‐Laporte, Han‐Na Kim, Stavroula Kanoni, Yukinori Okada, Jinyoung Byun, Younghun Han, Mohammed Jashim Uddin, George Davey Smith, Cristen J. Willer, Joseph D. Buxbaum, Juha Mehtonen, Hilary K. Finucane, Mattia Cordioli, Alicia R. Martin, Wei Zhou, Bogdan Paşaniuc, Hanna Julienne, Hugues Aschard, Huwenbo Shi, Loïc Yengo, Renato Polimanti, Maya Ghoussaini, Jeremy Schwartzentruber, Ian Dunham, Karolina Chwiałkowska, Margherita Francescatto, Amy Trankiem, Mary K. Balaconis, Lea K. Davis, Sulggi A. Lee, James R. Priest, Alessandra Renieri, Vijay G. Sankaran, David A. van Heel, Patrick Deelen, J. Brent Richards, Tomoko Nakanishi, Les Biesecker, V. Eric Kerchberger, J. Kenneth Baillie, Francesca Mari, Anna Bernasconi, J. Kenneth Baillie, Arif Canakoglu, Brooke N. Wolford, Annika Faucon, Atanu Kumar Dutta, Claudia Schurmann, Emi N. Harry, Ewan Birney, Huy Nguyen, Jamal Nasir, Mari Kaunisto, Matthew Solomonson, Nicole Dueker, Nirmal Vadgama, Sophie Limou, Souad Rahmouni, Hamdi Mbarek, Dima Darwish, Md Mesbah Uddin, Raquel Albertos, Jordi Pérez‐Tur, Ruolin Li, Lasse Folkersen, Ida Moltke, Nils Koelling, Alexander Teumer, Athanasios Kousathanas, Alicia Utrilla, Ricardo A. Verdugo, Ruth Zárate, Carolina Medina‐Gómez, David Gómez-Cabrero, Elena Carnero‐Montoro, Carmen L. Cadilla, Andrés Moreno‐Estrada, Adriana Garmendia, Leire Moya, Bahareh Sedaghati-khayat, Palwendé Romuald Boua, Marie-Julie Favé, Laurent C. Francioli, Audrey Lemaçon, Isabelle Migeotte, Sanjay Patel, Réka Várnai, József Szentpéteri, Csilla Sipeky, Francesca Colombo, Kathrin von Hohenstaufen, Píetro Lió, Costanza L. Vallerga, Qingbo Wang, Yosuke Tanigawa, Hogune Im, Chulho Han, Han Song, Jiwoo Lim, Y.‐A. Lee, Sugyeong Kim, Sangyoon Im, Biljana Atanasovska, Hajar Fauzan Ahmad, Cindy G. Boer, Philip R. Jansen, Lude Franke, Elżbieta Kaja, Dorota Pasko, Ingrid Kennis-Szilagyi, Sergey A. Kornilov, Vid Prijatelj, Ivana Nedeljković, Ilangkumaran Sivanadhan, Sarala Perumal, Sahar Esmaeeli, Nathaniel M. Pearson, Adam Auton, Janie F. Shelton, Anjali J. Shastri, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Jorge Esparza-Gordillo, Stella Aslibekyan, Jared O’Connell, Chelsea Ye, Catherine H. Weldon, Minoli A. Perera, Kevin J. O’Leary, Matthew Tuck, Travis J. O’Brien, David Meltzer, Peter H. O’Donnell, Edith A. Nutescu, Guang Yang, Cristina Alarcón, Stefanie Herrmann, Sophia Mazurek, Jeff Banagan, Zacharia Hamidi, April Barbour, Noora Raffat, Diana Moreno, Paula N. Friedman, Bart Ferwerda, Diederik van de Beek, Matthijs C. Brouwer, Alexander P. J. Vlaar, W. Joost Wiersinga, Daniëlle Posthuma, Elleke Tissink, A. H. Koos Zwinderman, Emil Uffelmann, Michiel A. van Agtmael, Anne Geke Algera, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije K. Bomers, Peter I. Bonta, Lieuwe D. J. Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, Sanne de Bruin, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Dave A. Dongelmans, Paul Elbers, Lucas M. Fleuren, Suzanne E. Geerlings, Bart F. Geerts, Teunis B. H. Geijtenbeek, Armand R. J. Girbes, Abraham Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura A. Hagens, Jörg Hamann, Vanessa Harris, Robert Hemke, Sabine Hermans, Leo Heunks, Markus W. Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Niels van Mourik, Jeannine F. Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom D. Y. Reijnders, Michiel Schinkel, Marcus J. Schultz, Alex R. Schuurman, Kim Sigaloff, Marry R. Smit, Cornelis Stijnis, Willemke Stilma, Charlotte E. Teunissen, Patrick Thoral, Anissa M. Tsonas, Marc van der Valk, Denise P. Veelo, Heder de Vries, Michèle van Vugt, Dorien Wouters, René Minnaar, Adrie Kromhout, Kees W. J. van Uffelen, Ruud A. Wolterman, Genevieve Roberts, Daniel J. Park, Catherine A. Ball, Marie V. Coignet, Shannon McCurdy, Spencer C. Knight, Raghavendran Partha, Brooke Rhead, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Miloš Pavlović, Eurie L. Hong, Kristin A. Rand, Ahna R. Girshick, Harendra Guturu, Asher Haug Baltzell, Souad Rahmouni, Julien Guntz, Y Beguin, Sara Pigazzini, Lindokuhle Nkambule, Youssef Bouysran, Adeline Busson, Xavier Peyrassol, Françoise Wilkin, Bruno Pichon, Guillaume Smits, Isabelle Vandernoot, Jean‐Christophe Goffard, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Julien Guiot, Laurent Jadot, Samira Azarzar, Patricia Dellot, Stéphanie Gofflot, Sabine Claassen, Axelle Bertrand, Gilles Parzibut, Mathilde Clarinval, Catherine Moermans, Olivier Malaise, Kamilia El Kandoussi, Raphaël Thonon, Pascale Huynen, Alyssia Mesdagh, Sofia Ferreira Melo, Nicolas Jacques, Emmanuel Di Valentin, François Giroule,
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed ...
Nature Portfolio
Gianluca Pellino, Mauro Podda, Francesco Pata, Salomone Di Saverio, Benedetto Ielpo, Benedetto Ielpo, Mauro Podda, Gianluca Pellino, Francesco Pata, Riccardo Caruso, Gianpiero Gravante, Salomone Di Saverio, A Orengia, Allam Venkata Prathyush Chowdary, Adarsh Kulkarni, Adnan Kuvvetli, Alberto Ordinola Navarro, Andrew M. Smith, A. Cavero Ibiricu, Aeris Jane D. Nacion, Amal Abdulwahab Alsaleh, Adel A Alhazmi, A Elmabri, Abdul Haseeb Wani, Ahmet Rencüzoğulları, Aingeru Sarriugarte Lasarte, Ainhoa Valle Rubio, Akshay Bavikatte, Anil Kumar, Al‐Radjid Jamiri, Ana Padilla, Alban Cacurri, A de San Ildefonso, Alberto Porcu, Alberto Sartori, Aldo Rocca, A Paz Yáñez, A Becaria, Alejandro Solís‐Peña, Aleksandar Sretenović, A Urbistondo, A Bandin, Alberto Lopes Najar, Andrea De Luca, Alex Boddy, Alexandros Charalabopoulos, Alexios Tzivanakis, Alfonso Amendola, Alfredo Ramírez Gutiérrez de Velasco, Ali Cihat Yıldırım, Alice Frontali, Aissatou Touré, Álvaro García‐Granero, Amaia Martínez Roldan, A Sanz Larrainzar, Ashani Ratnayake, Ana María González-Ganso, Ana Minaya‐Bravo, Avash Das, Andrea Bondurri, Andrea Costanzi, Andrea Lucchi, Andrea Mazzari, A Musig, Andrea Peloso, A. Piano, Andréa Police, Andrei Mihailescu, Andrés ́Pouy, Angela Romano, Angelo Iossa, A. 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Francesco Perrone, Maria Carmela Piccirillo, Paolo A. Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco‐Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, María Lorenza Muiesan, Miriam Lichtner, Carlo Calzetti, Nicola Duccio Salerno, Luigi Atripaldi, Marco Cascella, Massimo Costantini, Giovanni Dolci, Nicola Facciolongo, Fiorentino Fraganza, Marco Massari, Vincenzo Montesarchio, Cristina Mussini, Emanuele Alberto Negri, Gerardo Botti, Claudia Cardone, Piera Gargiulo, Adriano Gravina, Clorinda Schettino, Laura Arenare, Paolo Chiodini, Ciro Gallo, Francesco Perrone, Maria Carmela Piccirillo, Clorinda Schettino, Adriano Gravina, Piera Gargiulo, Claudia Cardone, Laura Arenare, Paolo A. 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Pasulo, Leonardo Gaglio, Roberto Del Fabbro, Leonardo Alborghetti, Paolo Bonfanti, Nicola Squillace, Giulia Giustinetti, Paola Columpsi, Marina Elena Cazzaniga, Serena Capici, Luca Sala, Riccardo Di Sciacca, Giacomo Mosca, Maria Rosa Pirozzi, Francesco Castelli, María Lorenza Muiesan, Franco Franceschini, Aldo M. Roccaro, Massimo Salvetti, Anna Paini, Luciano Corda, Chiara Ricci, Lina Rachele Tomasoni, Paola Nasta, Silvia Lorenzotti, Silvia Odolini, Emanuele Focà, Eugenia Quirós-Roldán, Marco Metra, Stefano Maria Magrini, Paolo Borghetti, Nicola Latronico, Simone Piva, Matteo Filippini, G. Tomasi, Francesco Zuccalà, Sergio Cattaneo, Francesco Scolari, Nicola Bossini, Mario Gaggiotti, Martina Properzi, Miriam Lichtner, Cosmo Del Borgo, Raffaella Marocco, Valeria Belvisi, Tiziana Tieghi, Margherita De Masi, Paola Zuccalà, Paolo Fabietti, Angelo Vetica, V. S. Mercurio, Anna Carraro, Laura Fondaco, Blerta Kertusha, Ambrogio Curtolo, Emanuela Del Giudice, Riccardo Lubrano, Maria Gioconda Zotti, Antonella Puorto, Marcello Ciuffreda, Antonella Sarni, Gabriella Monteforte, Domenico M. Romeo, Emanuela Viola, C. 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BioMed Central