Xènia Albà, Rosa Ventura, Karim Lekadir, Alejandro F. Frangi,
We propose an automatic technique to segment scar and classify the myocardial tissue of the left ventricle from Delay Enhancement (DE) MRI. The method uses multiple region growing with two types of regions and automatic seed initialization. The region growing criteria is based on intensity distance and the seed initialization is based on a thresholding technique. We refine the obtained segmentation with some morphological operators and geometrical constraints to further define the infarcted area. ...
Tópico(s): Advanced MRI Techniques and Applications
2013 - Springer Science+Business Media | Lecture notes in computer science
Following wound healing, skin is replaced by a specialized tissue called scar. Sometime, this scar can become pathologic, called hypertrophic scar, with a high amount of extracellular matrix, capillaries, and myofibroblast persistence. To understand the mechanisms at the origin of the fibrosis is paramount to treat patients, but despite few animal models and in vitro studies using mainly human pathological cells cultured on plastic on monolayer, the treatment of these fibrotic scars remains unsatisfactory. ...
Tópico(s):
2021 - Springer Science+Business Media | Methods in molecular biology
Iulia A. Popescu, Benjamin Irving, Alessandra Borlotti, Erica DallʼArmellina, Vicente Grau,
Abnormal myocardial motion occurs in many cardiac pathologies, though in different ways, depending on the disease, some of which can result in negative clinical outcomes. Therefore, a better understanding of the contractile capability of the tissue is crucial in providing an improved and patient-specific clinical outcome [4]. Cardiovascular Magnetic Resonance Imaging (CMR) is considered the gold standard for the assessment of cardiac function and has the potential to also be used for routine tissue ...
Tópico(s): Medical Imaging Techniques and Applications
2017 - Springer Science+Business Media | Lecture notes in computer science
K. v. Olshausen, H. C. Mehmel, W. Kübler,
The healing process of an acute myocardial infarction involves the deposition of collagen and the formation of scar tissue which alter the acoustic properties and the wall thickness of the affected ventricular wall segment. Although M-mode echocardiography is limited in scanning the left ventricular cavitiy, several studies claimed a high degree of success in detecting infarcted scar tissue (2, 8). 2D-echocardiography has been shown to be superior to M-mode in analyzing left ventricular wall motion ...
Tópico(s): Cardiac Valve Diseases and Treatments
1982 - Springer Nature | Developments in cardiovascular medicine
Heart failure, a worldwide health problem, is most commonly due to ischemic cardiomyopathy (ICM) with previous myocardial infarction(s). Herein, insights into the infarct scar as living tissue (and which resembles heart valve leaflets) are reviewed. This includes: a) its population of persistent, metabolically active myofibroblasts, whose elaboration of angiotensin II regulates (via AT1 receptor-ligand binding) their production of TGF-β1 and, in turn, type I fibrillar collagen; b) its neovasculature, ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2003 - Springer Nature | Progress in experimental cardiology
Ian Dixon, V. Pelouch, Rajat Sethi, Naranjan S. Dhalla,
A significant body of evidence from observations in clinical and experimental models has accumulated to demonstrate that a progressive loss of intrinsic contractility occurs in surviving myocardium after large transmural myocardial infarction, and the degree of cardiac pump dysfunction in viable tissue has been correlated to the size of the initial infarct [1–4]; however, no common biochemical defect has been identified to explain the loss of cardiac function [5]. Previous work indicates that structural ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
1996 - Springer Nature | Developments in cardiovascular medicine
Hurts very often leave signs. These signs can be more or less visible. They can be both physical and psychological. We usually call them “scars”. In English, “scar formation” and “healing” are synonyms. In medicine, the formation of scars depends on the conditions of the tissue, on the whole person hurt and on environmental factors. Hurts can involve just one individual or a group of people (a family, a community, even a whole nation). So, we can find scars on single bodies (skin, bones, organs) and ...
Tópico(s): Human Behavior and Motivation
2022 - Springer International Publishing | Springer series in design and innovation
Adrienne K. Scott, Erin Louwagie, Kristin M. Myers, Michelle L. Oyen,
... region. Finite element modeling of the uterus and scar tissue presents a promising method to further understand and predict uterine ruptures. Using patient dimensions of an at-term uterus, a C-section scar was modeled with an applied intrauterine pressure to ...
Tópico(s): Pelvic and Acetabular Injuries
2024 - Springer International Publishing | Lecture notes in computational vision and biomechanics
Jun Chen, Guang Yang, Zhifan Gao, Hao Ni, Elsa D. Angelini, Raad Mohiaddin, Tom Wong, Yanping Zhang, Xiuquan Du, Heye Zhang, Jennifer Keegan, David Firmin,
Late Gadolinium Enhanced Cardiac MRI (LGE-CMRI) for detecting atrial scars in atrial fibrillation (AF) patients has recently emerged as a promising technique to stratify patients, guide ablation therapy and predict treatment success. Visualisation and quantification of scar tissues require a segmentation of both the left atrium (LA) and the high intensity scar regions from LGE-CMRI images. These two segmentation tasks are challenging due to the cancelling of healthy tissue signal, low signal-to-noise ...
Tópico(s): Advanced X-ray and CT Imaging
2018 - Springer Science+Business Media | Lecture notes in computer science
Shaheim Ogbomo-Harmitt, Jakub Grzelak, Ahmed Qureshi, Andrew P. King, Oleg Aslanidi,
... extensive research has focused on the relationship between scar tissue in the left atrium (LA) and AF, and ... CA therapy strategies. However, quantifying and segmenting LA scar tissue requires significant data pre-processing from well-trained clinicians. Hence, deep learning (DL) has been proposed to automatically segment the LA fibrotic scar from late gadolinium-enhanced cardiac magnetic resonance (LGE- ...
Tópico(s): Advanced MRI Techniques and Applications
2023 - Springer Science+Business Media | Lecture notes in computer science
Magdalena Plotczyk, Francisco Jiménez,
... effect and injecting them directly into wounds or scar tissue to improve the clinical outcomes. Alternatively, elucidating the paracrine effect of transplanted follicles would open up new avenues for therapeutic discovery, to replicate the combination of required factors that facilitate healing or scar remodelling.
Tópico(s): Body Contouring and Surgery
2022 - Springer Nature | Stem cell biology and regenerative medicine
Alan Z. Yang, Daniela Lee, Daniella Dennis, Samuel J. Lin,
... in contraction and the formation of non-physiologic scar tissue. However, recent advancements with induced regeneration using biologically active scaffolds have demonstrated that it is possible to intervene during the healing process to partially or near-completely restore the physiologic function of damaged skin or peripheral nerves. The aim of these scaffolds is to promote regeneration and minimize the contraction and scar formation mediated by stromal fibroblasts. For instance, some ...
Tópico(s): Pluripotent Stem Cells Research
2024 - Springer International Publishing | Contemporary diabetes
Tamishta Hensman, Peter Sherren,
... was used to differentiate between ongoing oedema and scar tissue, thereby informing ongoing immunosuppression and management of his ...
Tópico(s): Cardiac Structural Anomalies and Repair
2023 - Springer International Publishing | Lessons from the ICU
E. N. Borkhunova, Sergey Pozyabin, A.I. Dovgii, Mikhail Kachalin,
... regenerate, and a decrease in the formation of scar tissue. In addition, under the influence of the MSC ...
Tópico(s): Periodontal Regeneration and Treatments
2023 - Springer International Publishing | Lecture notes in networks and systems
Produção Nacional
Revisado por pares
Justino Santos, Vinícius Ponte Machado, Luciano Oliveira, Washington L. C. dos‐Santos, Nayze Lucena Sangreman Aldeman, Ângelo Duarte, Rodrigo Veras,
... common kidney disease characterized by the deposition of scar tissue, which replaces the renal parenchyma, and is quantified ...
Tópico(s): Digital Imaging for Blood Diseases
2022 - Springer Science+Business Media | Lecture notes in computer science
... occur during this transition of scarless regeneration to scar wound healing. The later part of the chapter covers current tissue engineering strategies which use fetal regeneration knowledge to ...
Tópico(s): Reconstructive Surgery and Microvascular Techniques
2022 - Mary Ann Liebert, Inc. | Tissue Engineering
Nicolas Cedilnik, Jean‐Marc Peyrat,
... equations, to measure the thickness of one specific tissue in this particular configuration. After describing the mathematical formulation of our “weighted thickness” definition, we show on synthetic geometries in one, and two dimensions that it outputs the expected results. We then present three possible applications of our method on cardiac imaging data: measuring the muscular thickness of a ventricle with fat infiltration; measuring the thickness of an infarct scar; visualising the transmural extent of an infarct scar.
Tópico(s): Coronary Interventions and Diagnostics
2023 - Springer Science+Business Media | Lecture notes in computer science
Dolors Serra, Paula Franco, Pau Romero, Ignacio Garcı́a-Fernández, Miguel Lozano, David Soto, Diego Penela, Antonio Berruezo, Óscar Cámara, Rafael Sebastián,
... complex substrate remodeling that combines dead and viable tissue in the scar region. Within such regions, slow conduction channels (SCC) might be present, being formed by viable tissue with altered electrical properties that can change the ...
Tópico(s): Cardiac Arrhythmias and Treatments
2022 - Springer Science+Business Media | Lecture notes in computer science
Produção Nacional
Revisado por pares
Louisa S. Ponnampalam, Lucy W. Keith‐Diagne, Miriam Marmontel, Christopher D. Marshall, Roger L. Reep, James Powell, Helene Marsh,
... adult Florida manateesFlorida manatee (Trichechus Manatus Latirostris) bear scars from such encounters, with about a quarter showing evidence of being hit on at least ten occasions. Sirenians accumulate contaminantsContaminants because they feed on large quantities of aquatic plants. However, none of the persistent contaminantsContaminants identified in sirenian tissues have been definitively associated with mortalityMortality, morbidity or ...
Tópico(s): Coral and Marine Ecosystems Studies
2022 - Springer International Publishing | Ethology and behavioral ecology of marine mammals
Ronak Reshamwala, Francesca Oieni, Megha Shah,
... the tissue repair and regeneration than just the scar formation. Moreover, there are several other pathways to tissue regrowth and functional regeneration than with the stem ...
Tópico(s):
2023 - Future Medicine | Regenerative Medicine
Produção Nacional
Thales Lage Bicalho Bretas, Aline Tanus, Marcia Linhares, Maria Cláudia Almeida Issa,
Scars result from the substitution of a damaged skin to a new and abnormal tissue following an injury. Ablative devices, including the Erbium and carbon dioxide lasers, have shown to be effective in improving the appearance of scars, including mature burn scars. The CO2 laser promotes thermal fractionated ablation of the skin, and the resultant selective healing stimuli improve the altered tissue. The scars, then, become more homogeneous with the surrounding skin. The carbon dioxide laser can be ...
Tópico(s): Sympathectomy and Hyperhidrosis Treatments
2017 - Springer International Publishing | Clinical approaches and procedures in cosmetic dermatology
Produção Nacional
Roberto Mattos, Juliana Merheb Jordão, Kelly Cristina Signor, Luciana Gasques de Souza,
The knowledge of microenvironment of tissue repair enables better understanding of the healing process and the techniques currently employed for its correction. There are different types of scars and the treatment should be chosen according to lesion. Laser mechanism of action on scars is based on two pillars, to reduce blood flow and to reorganize collagen fibers. Devices available for scar treatment include intense pulsed light (IPL), in the vascular mode, non-ablative lasers, and ablative lasers. ...
Tópico(s): Laser Material Processing Techniques
2017 - Springer International Publishing | Clinical approaches and procedures in cosmetic dermatology
Produção Nacional
Roberto Mattos, Juliana Merheb Jordão, Kelly Cristina Signor, Luciana Gasques de Souza,
The knowledge of microenvironment of tissue repair enables better understanding of the healing process and the techniques currently employed for its correction. There are different types of scars and the treatment should be chosen according to lesion. Laser mechanism of action on scars is based on two pillars, to reduce blood flow and to reorganize collagen fibers. Devices available for scar treatment include intense pulsed light (IPL), in the vascular mode, nonablative lasers, and ablative lasers. ...
Tópico(s): Sympathectomy and Hyperhidrosis Treatments
2016 - Springer International Publishing | Clinical approaches and procedures in cosmetic dermatology
Produção Nacional
Thales Lage Bicalho Bretas, Aline Tanus, Marcia Linhares, Maria Cláudia Almeida Issa,
Scars result from the substitution of a damaged skin to a new and abnormal tissue following an injury. Ablative devices, including the Erbium and carbon dioxide lasers, have shown to be effective in improving the appearance of scars, including mature burn scars. The CO2 laser promotes thermal fractionated ablation of the skin, and the resultant selective healing stimuli improve the altered tissue. The scars, then, become more homogeneous with the surrounding skin. The carbon dioxide laser can be ...
Tópico(s): Laser Applications in Dentistry and Medicine
2018 - Springer International Publishing | Clinical approaches and procedures in cosmetic dermatology
Produção Nacional
Roberto Mattos, Juliana Merheb Jordão, Kelly Cristina Signor, Luciana Gasques de Souza,
The knowledge of microenvironment of tissue repair enables better understanding of the healing process and the techniques currently employed for its correction. There are different types of scars and the treatment should be chosen according to lesion. Laser mechanism of action on scars is based on two pillars, to reduce blood flow and to reorganize collagen fibers. Devices available for scar treatment include intense pulsed light (IPL), in the vascular mode, non-ablative lasers, and ablative lasers. ...
Tópico(s): Sympathectomy and Hyperhidrosis Treatments
2018 - Springer International Publishing | Clinical approaches and procedures in cosmetic dermatology
Alexei Verkhratsky, Arthur M. Butt,
... and compensation. The damaged area of the nervous tissue is substituted with a fibrotic scar produced by stromal cells, whereas reactive astrocytes form perilesional barrier protecting healthy nervous tissue.
Tópico(s): Long-Term Effects of COVID-19
2023 - Multidisciplinary Digital Publishing Institute | Neuroglia
Sabrina Reiml, Tanja Kurzendorfer, Dániel Tóth, Peter Mountney, Maria Panayiotou, Jonathan M. Behar, Christopher A. Rinaldi, Kawal Rhode, Andreas Maier, Alexander Brost,
In 2014, about 26 million people were suffering from heart failure. Symptomatic heart failure is treated by cardiac resynchronization therapy. However, 30% to 50% do not clinically respond after the implantation of a biventricular pacemaker. To improve the success rate, the quantification of a patient’s scar burden is very important. Lategadolinium- enhanced magnetic resonance imaging is used to visualize regions of scarring in the left ventricle. Scar is very hard to visualize and interpret in ...
Tópico(s): Advanced MRI Techniques and Applications
2017 - Springer Nature | Informatik aktuell
Scar tissue is the result of all wound healing processes. This has major implications for the patient, as scar tissue is usually less mechanically resistant, is aesthetically displeasing, and can cause functional impairment through contractures and itch. The extent of scar formation is mostly influenced by the duration and extent of the inflammatory phase of wound healing. Shortening the inflammatory phase can lead to healthier scar tissue. After wound healing, a number of early interventions have ...
Tópico(s): Facial Rejuvenation and Surgery Techniques
2020 - Springer International Publishing | Updates in clinical dermatology
Simon Stebler, Michael Raghunath,
Tópico(s): Inhalation and Respiratory Drug Delivery
2021 - Springer Science+Business Media | Methods in molecular biology
... profoundly affect each other’s cyclic behavior and tissue volume. Upon excisional skin wounding, newly regenerated hair follicles in the center of the scar secrete signaling factors that induce reprograming of the ...
Tópico(s): Skin and Cellular Biology Research
2022 - Springer Nature | Stem cell biology and regenerative medicine