Yong Sup Lee, Sun Nam Kim, Yong Sil Lee, Jae Yeol Lee, Chong-Kyo Lee, Hae Soo Kim, Hokoon Park,
... G. L.Zipp, R. J.Dalga, F. J.Schwende, G. M.Howard, G. E.Padbury, L. N. ... G. L.Zipp, M. J.Ruwart, F. J.Schwende, W.-ZZhong, G. E.Padbury, R. J.Dalga, ...
Tópico(s): Multicomponent Synthesis of Heterocycles
2000 - Wiley | Archiv der Pharmazie
Suvit Thaisrivongs, Harvey I. Skulnick, Steve R. Turner, Joseph W. Strohbach, Rubén Tommasi, Paul D. Johnson, Paul A. Aristoff, Thomas M. Judge, Ronald B. Gammill, Jeanette K. Morris, Karen R. Romines, R. Alan Chrusciel, Roger R. Hinshaw, Kong-Teck Chong, W. Gary Tarpley, Susan M. Poppe, David E. Slade, Janet C. Lynn, Miao-Miao Horng, Paul K. Tomich, Eric P. Seest, Lester A. Dolak, W. Jeffrey Howe, Gina M. Howard, Francis J. Schwende, Lisa N. Toth, Guy E. Padbury, Grace J. Wilson, Lihua Shiou, Gail L. Zipp, Karen F. Wilkinson, Bob D. Rush, Mary J. Ruwart, Kenneth A. Koeplinger, Zhiyang Zhao, Serena L. Cole, Renee M. Zaya, Thomas J. Kakuk, Musiri N. Janakiraman, Keith David Watenpaugh,
... W. Jeffrey Howe, Gina M. Howard, Francis J. Schwende, Lisa N. Toth, Guy E. Padbury, Grace J. ...
Tópico(s): HIV Research and Treatment
1996 - American Chemical Society | Journal of Medicinal Chemistry
Donald Wiesler, Frank J. Schwende, Marvin Carmack, Miloš V. Novotný,
... the mouse Mus musculusDonald P. Wiesler, Frank J. Schwende, Marvin Carmack, and Milos NovotnyCite this: J. Org. ...
Tópico(s): Advanced Chemical Sensor Technologies
1984 - American Chemical Society | The Journal of Organic Chemistry
Miloš V. Novotný, Francis J. Schwende, M. J. Hartigan, J. E. Purcell,
... chromatography with ultraviolet spectrometric detectionM. Novotny, F. J. Schwende, M. J. Hartigan, and J. E. PurcellCite this: ...
Tópico(s): Analytical Chemistry and Chromatography
1980 - American Chemical Society | Analytical Chemistry
Francis J. Schwende, D. D. Gleason,
... columns in low thermal mass cages F. J. Schwende, Corresponding Author F. J. Schwende Drug Metabolism Research, Pharmaceutical Research and Development, Upjohn ... for more papers by this author F. J. Schwende, Corresponding Author F. J. Schwende Drug Metabolism Research, Pharmaceutical Research and Development, Upjohn ...
Tópico(s): Clay minerals and soil interactions
1985 - Wiley | Journal of High Resolution Chromatography
Produção Nacional
Revisado por pares
Alvin Chandra, Carísi Anne Polanczyk, Brian Claggett, Muthiah Vaduganathan, Milton Packer, Martin Lefkowitz, Jean L. Rouleau, Jiankang Liu, Victor Shi, H. Schwende, Michael R. Zile, Akshay S. Desai, Marc A. Pfeffer, John J.V. McMurray, Scott D. Solomon, Eldrin F. Lewis,
Abstract Aims Heart failure (HF) is associated with poor health‐related quality of life (HRQL). Patients with HF with preserved ejection fraction (HFpEF) have similar HRQL impairment as those with reduced ejection fraction. This study describes the impact of sacubitril/valsartan on HRQL in patients with HFpEF enrolled in the PARAGON‐HF trial. Methods and results Patients completed the Kansas City Cardiomyopathy Questionnaire (KCCQ) and EuroQol (EQ‐5D) at randomization, 4, 8 months, and annually thereafter. ...
Tópico(s): Cardiac pacing and defibrillation studies
2022 - Elsevier BV | European Journal of Heart Failure
Domingo A. Pascual‐Figal, Rolf Wachter, Michele Senni, Weibin Bao, Adele Noè, H. Schwende, Dmytro Butylin, Margaret F. Prescott, Jacek Gniot, М Е Можейко, Małgorzata Lelonek, A. Reyes Domínguez, Thomas Horacek, Enrique Garcia del Rio, Zhanna Kobalava, Christian Mueller, Yüksel Çavuşoğlu, Ewa Straburzyńska−Migaj, Miroslav Slanina, Juergen vom Dahl, Michele Senni, Alisdair Ryding, Andrew Moriarty, Manuel Beltrán Robles, Julio Núñez, Antonio García Quintana, Thorsten Nitschke, José Manuel García Pinilla, Luis Almenar Bonet, Said Chaaban, Samia Filali zaatari, Jindřich Špinar, Włodzimierz J. Musiał, Khaled Abdelbaki, Jan Bělohlávek, Wolfgang Fehske, Michael Carlos Bott, Geir Hoegalmen, Marisa Crespo Leiro, İsmail Türkay Özcan, Wilfried Müllens, Radim Kryza, Riadh Al‐Ani, Krystyna Łoboz‐Grudzień, Lyudmila Ermoshkina, Silvia Hojerova, Alberto Alfredo Fernandez, Lenka Špinarová, Harald Lapp, Efraim Bulut, Filipa Almeida, A. A. Vishnevsky, Margita Belicová, Domingo A. Pascual‐Figal, Klaus K. Witte, Kenneth Wong, Walter Droogné, Marc Delforge, Martin Peterka, Hans‐Georg Olbrich, Stefano Carugo, Jadwiga Nessler, Thao Huynh McGill, Burkhard Huegl, İbrahim Akın, Ilídio Moreira, А. Н. Багликов, Jeetendra Thambyrajah, Chris Hayes, Marcelo Barrionuevo, Zerrin Yiğit, Hakkı Kaya, Zdeněk Klimsa, Martin Radvan, C Kadel, Ulf Landmesser, Giuseppe Di Tano, Malgorzata Buksinska Lisik, Cândida Fonseca, Luís Oliveira, Irene Marques, Luís M.G. Santos, Egon Lenner, Peter Letavay, Manuel Gómez‐Bueno, Paula Mota, Aaron Wong, Kristian Bailey, Paul Foley, Eduardo Hasbani, Sean Virani, Tony Abdel Massih, Shukri AlSaif, Miloš Táborský, Marta Kaislerova, Zuzana Moťovská, Aron Ariel Cohen, Damien Logeart, Dierk Endemann, Daniel Ferreira, Dulce Brito, P Kycina, Entela Bollano, Enrique Galve Basilio, Lorenzo Fácila, Marcos Garcı́a Aguado, Lilia Beatriz Schiavi, Daniel Francisco Zivano, Eva Lonn, Ali El Sayed, Anne‐Catherine Pouleur, Alex Heyse, Alexandr Schee, Rostislav Polášek, Marek Houra, Christophe Tribouilloy, Marie France Séronde, Michel Galinier, Michel Noutsias, Peter Schwimmbeck, Ingo Voigt, Dirk Westermann, Giovanni Pulignano, Johnny Vegsundvaag, Alexandre Antunes, Pedro Monteiro, Ján Števlík, Eva Gonçalvesová, Beata Hulkoova, Antonio Fernández-Giménez, Ceri Davies, Iain Squire, Philippe Meyer, Richard Sheppard, Tayfun Şahı̇n, K Sochor, Guillaume De Geeter, Rolf Wachter, Alexander Schmeißer, Joachim Weil, Ana Oliveira Soares, Olga Bulashova Vasilevna, Andrey Oshurkov, Shahid Junejo Sunderland, Jason D. Glover, Tomas Exequiel, Eric Decoulx, Sven Meyer, Thomas Muenzel, Fernando Friões, G ARBOLISHVILI, A Tokarcíková, Patric Karlström, Joan Carles Trullàs Vila, Gonzalo Pena Perez, Rajiv Sankaranarayanan, Thuraia Nageh, Diego Alasia, Marwan M. Refaat, Burcu Demirkan, Jehad Al‐Buraiki, Shadi Karabsheh,
This study examined the effects of sacubitril/valsartan on N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels and determined patient characteristics associated with favorable NT-proBNP reduction response. NT-proBNP levels reflect cardiac wall stress and predict event risk in patients with acute decompensated heart failure (ADHF). Post-hoc analysis of the TRANSITION (Comparison of Pre- and Post-discharge Initiation of Sacubitril/Valsartan Therapy in HFrEF Patients After an Acute Decompensation ...
Tópico(s): Mechanical Circulatory Support Devices
2020 - Elsevier BV | JACC Heart Failure
Rolf Wachter, Michele Senni, Jan Bělohlávek, Ewa Straburzyńska−Migaj, Klaus K. Witte, Zhanna Kobalava, Cândida Fonseca, Eva Gonçalvesová, Yüksel Çavuşoğlu, Alberto Fernández, Said Chaaban, Ellen Bøhmer, Anne‐Catherine Pouleur, Christian Mueller, Christophe Tribouilloy, Eva Lonn, Jehad Al Buraiki, Jacek Gniot, М Е Можейко, Małgorzata Lelonek, Adele Noè, H. Schwende, Weibin Bao, Dmytro Butylin, Domingo A. Pascual‐Figal,
To assess tolerability and optimal time point for initiation of sacubitril/valsartan in patients stabilised after acute heart failure (AHF).TRANSITION was a randomised, multicentre, open-label study comparing two treatment initiation modalities of sacubitril/valsartan. Patients aged ≥ 18 years, hospitalised for AHF were stratified according to pre-admission use of renin-angiotensin-aldosterone system inhibitors and randomised (n = 1002) after stabilisation to initiate sacubitril/valsartan either ≥ 12-h ...
Tópico(s): Cardiac pacing and defibrillation studies
2019 - Elsevier BV | European Journal of Heart Failure
Michele Senni, Rolf Wachter, Klaus K. Witte, Ewa Straburzyńska−Migaj, Jan Bělohlávek, Cândida Fonseca, Christian Mueller, Eva Lonn, Arhit Chakrabarti, Weibin Bao, Adele Noè, H. Schwende, Dmytro Butylin, Domingo A. Pascual‐Figal,
Abstract Aims Sacubitril/valsartan has shown efficacy and tolerability in patients with heart failure (HF) and reduced ejection fraction (HFrEF) in the ambulatory setting (PARADIGM‐HF), and following stabilisation of acutely decompensated HF (ADHF) (PIONEER‐HF and TRANSITION). However, data are lacking for the initiation of sacubitril/valsartan in newly diagnosed ( de novo ) HFrEF. Here, we assess the tolerability of initiating sacubitril/valsartan following ADHF in TRANSITION subgroups of patients with ...
Tópico(s): Cardiovascular Function and Risk Factors
2019 - Elsevier BV | European Journal of Heart Failure
P. Sala, O. Adrian Pfiffner, Marcel Frehner,
... Säntis area, the Säntis Thrust and the Sax-Schwende Fault, are also implemented in the model. The ...
Tópico(s): Geological Modeling and Analysis
2014 - Springer Nature | Swiss Journal of Geosciences
Isabel Schwende, Tuan D. Pham,
With the massive production of genomic and proteomic data, the number of available biological sequences in databases has reached a level that is not feasible anymore for exact alignments even when just a fraction of all sequences is used. To overcome this inevitable time complexity, ultrafast alignment-free methods are studied. Within the past two decades, a broad variety of nonalignment methods have been proposed including dissimilarity measures on classical representations of sequences like k- ...
Tópico(s): Genomics and Phylogenetic Studies
2013 - Oxford University Press | Briefings in Bioinformatics
... Gniot J, Mozheiko M, Lelonek M, Noè A, Schwende H, Bao W, Butylin D, Pascual‐Figal D, ...
Tópico(s): Pharmaceutical Practices and Patient Outcomes
2012 - Lippincott Williams & Wilkins | Circulation Heart Failure
Noel A. Powell, Jeffrey T. Kohrt, Kevin J. Filipski, Michael D. Kaufman, Derek Sheehan, Jeremy E. Edmunds, Amy M. Delaney, Yuli Wang, Francis Bourbonais, Doh‐Yeel Lee, Frank J. Schwende, Fang Sun, Pat McConnell, Cornel Catana, Huifen Chen, Jeffrey F. Ohren, Lisa A. Perrin,
Tópico(s): Enzyme function and inhibition
2011 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
P. Wolkenstein, Marie‐Anne Loriot, Antoine Flahault, Michel Cadilhac, Éric Caumes, M. Eliaszewicz, Philippe Beaune, Jean‐Claude Roujeau, O. Chosidow,
... A. Zhao Z. Peterson T. Leone J.W. Schwende F.S. Heinrikson R.L. Tomasselli A.G. ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2005 - Elsevier BV | Journal of Investigative Dermatology
Jeffrey A. Pfefferkorn, Richard A. Nugent, Rebecca J. Gross, Meredith Greene, Mark A. Mitchell, Matthew T. Reding, Lee Funk, Rebecca M. Anderson, Peter A. Wells, John A. Shelly, Robert A. Anstadt, B.C. Finzel, Melissa S. Harris, Robert E. Kilkuskie, Laurice A. Kopta, Francis J. Schwende,
A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2005 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Jeffrey A. Pfefferkorn, Meredith Greene, Richard A. Nugent, Rebecca J. Gross, Mark A. Mitchell, B.C. Finzel, Melissa S. Harris, Peter A. Wells, John A. Shelly, Robert A. Anstadt, Robert E. Kilkuskie, Laurice A. Kopta, Francis J. Schwende,
A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern heterobiaryl region of the template led to the synthesis of several potent and orally bioavailable lead compounds. X-ray crystallography studies were also performed to understand the interaction of these inhibitors with HCV NS5B polymerase.
Tópico(s): Biochemical and Molecular Research
2005 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Roger J. Brideau, Mary L. Knechtel, Audris Huang, Valerie Vaillancourt, Ellen E. Vera, Nancee L. Oien, Todd A. Hopkins, Janet L. Wieber, Karen F. Wilkinson, Bob D. Rush, Francis J. Schwende, Michael W. Wathen,
We identified a novel class of 4-oxo-dihydroquinolines represented by PNU-183792 which specifically inhibit herpesvirus polymerases. PNU-183792 was highly active against human cytomegalovirus (HCMV, IC(50) value 0.69 microM), varicella zoster virus (VZV, IC(50) value 0.37 microM) and herpes simplex virus (HSV, IC(50) value 0.58 microM) polymerases but was inactive (IC(50) value >40 microM) against human alpha (alpha), gamma (gamma), or delta (delta) polymerases. In vitro antiviral activity against HCMV ...
Tópico(s): Viral-associated cancers and disorders
2002 - Elsevier BV | Antiviral Research
Tomoya Takahashi, Ayako Kamimura,
... root sheath keratinocytes (Hoffmann et al., 1996Hoffmann R. Schwende H. Happle R. Distribution of protein kinase C ...
Tópico(s): NF-κB Signaling Pathways
2001 - Elsevier BV | Journal of Investigative Dermatology
The roles of protein kinase C (PKC) isoenzymes in the differentiation process of THP-1 cells are investigated. Inhibition of PKC by RO 31-8220 reduces the phagocytosis of latex particles and the release of superoxide, prostaglandin E2 (PGE2), and tumour necrosis factor (TNF)-α. The proliferation of THP-1 cells is slightly enhanced by RO 31-8220. Stable transfection of THP-1 cells with asPKC-α, and incubation of THP-1 cells with antisense (as) PKC-α oligodeoxynucleotides reduces PKC-α levels and PKC ...
Tópico(s): Melanoma and MAPK Pathways
2000 - Elsevier BV | Cellular Signalling
Kenneth A. Koeplinger, Zhiyang Zhao, T. Peterson, Joseph W. Leone, Francis S. Schwende, Robert L. Heinrikson, Alfredo G. Tomasselli,
In preclinical pharmacokinetic studies and in in vitro rat, dog, and human primary hepatocyte incubations, the sulfonamide (-NH-SO(2)-) bond of a potent inhibitor of the HIV-1 protease containing the p-cyanopyridinyl moiety (PNU-109112), undergoes metabolic cleavage to form the corresponding amine metabolite (PNU-143070). Strikingly, a compound, PNU-140690, obtained by substituting the cyanopyridinyl group of PNU-109112 with a trifluoropyridinyl moiety, was stable under the same in vivo and in vitro ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
1999 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Harvey I. Skulnick, Paul D. Johnson, Paul A. Aristoff, Jeanette K. Morris, Kristine D. Lovasz, W. Jeffrey Howe, Keith David Watenpaugh, Musiri N. Janakiraman, David J. Anderson, Robert J. Reischer, Theresa Schwartz, Lee S. Banitt, Paul K. Tomich, Janet C. Lynn, Miao-Miao Horng, Kong-Teck Chong, Roger R. Hinshaw, Lester A. Dolak, Eric P. Seest, Francis J. Schwende, Bob D. Rush, Gina M. Howard, Lisa N. Toth, Karen R. Wilkinson, Thomas J. Kakuk, Carol W. Johnson, Serena L. Cole, Renee M. Zaya, Gail L. Zipp, Peggy L. Possert, Robert J. Dalga, Wei-Zhu Zhong, Marta G. Williams, Karen R. Romines,
Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors, but these compounds lacked significant antiviral activity in cell culture. Substitution of a sulfonamide group at the meta position, however, produces compounds with excellent HIV protease binding affinity and antiviral activity. Guided by an iterative structure-based drug design process, we have prepared and evaluated a number of these derivatives, which ...
Tópico(s): Click Chemistry and Applications
1997 - American Chemical Society | Journal of Medicinal Chemistry
H. Schwende, Edith Fitzke, Petra Ambs, Peter Dieter,
Abstract Human THP-1 leukemia cells differentiate along the monocytic lineage following exposure to phorbol-12-myristate-13-acetate (PMA) or 1,25-dihydroxyvitamin D3 (VD3). In the monocytic cell line THP-1, PMA treatment resulted in a more differentiated phenotype than VD3, according to adherence, loss of proliferation, phagocytosis of latex beads, and expression of GD11b and CD14. Both differentiating substances induced similar effects in the release of superoxide anions (O2-). VD3-differentiated ...
Tópico(s): Metabolism, Diabetes, and Cancer
1996 - Oxford University Press | Journal of Leukocyte Biology
Peter Dieter, Petra Ambs, Edith Fitzke, Hisashi Hidaka, Ralf Hoffmann, H. Schwende,
LPS and liposome-encapsulated MTP-PE induce liver macrophages cytotoxicity against tumor target cells and a release of TNF-alpha, nitric oxide, and eicosanoids but not a generation of superoxide anions. Neither agent elicits a formation of inositol phosphates, a change in intracellular free calcium, or a translation of protein kinase C-beta. Inhibition or down-regulation of protein kinase C does not inhibit the release of TNF-alpha and nitric oxide but inhibits the formation of prostanoids. In contrast ...
Tópico(s): Nanoparticle-Based Drug Delivery
1995 - American Association of Immunologists | The Journal of Immunology
Justus Duyster, H. Schwende, Edith Fitzke, Hisashi Hidaka, Peter Dieter,
In contrast with protein kinase C (PKC)-beta, PKC-delta is exclusively detectable in the membrane fraction of liver macrophages. After long-term treatment with phorbol 12-myristate 13-acetate (PMA) PKC-beta is depleted faster (within 3 h) than PKC-delta (> 7h). Simultaneously, pretreatment with PMA for 3 h inhibits the PMA- and zymosan-induced generation of superoxide and the PMA-induced formation of prostaglandin (PG) E2, whereas a preincubation of more than 7 h is required to affect the zymosan-induced ...
Tópico(s): Computational Drug Discovery Methods
1993 - Portland Press | Biochemical Journal
... C‐β but not PKC‐δ [Duyster, J., Schwende, H., Fitzke, E., Hidaka H. & Dieter P. (1993) ...
Tópico(s): Alcohol Consumption and Health Effects
1993 - Wiley | European Journal of Biochemistry
Francis J. Schwende, Richard C. Lewis,
A sensitive and precise method for the determination of nicorandil, a new anti-anginal medication, is reported. The method involves solid-phase extraction of the drug and internal standard using Bond-Elut® C18 extraction columns, reversed-phase high-performance liquid chromatography on a Zorbax®-Phenyl column and detection with photoconductivity and ultraviolet detection in series. Photoconductivity, performed with the Tracor 965 photoconductivity detector, provided a limit of detection of 2 ng/ ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1990 - Elsevier BV | Journal of Chromatography B Biomedical Sciences and Applications
Francis J. Schwende, D. Wiesler, James W. Jorgenson, Marvin Carmack, Miloš V. Novotný,
Tópico(s): Adipose Tissue and Metabolism
1986 - Springer Science+Business Media | Journal of Chemical Ecology
Francis J. Schwende, D. Wiesler, Miloš V. Novotný,
Tópico(s): Meat and Animal Product Quality
1984 - Birkhäuser | Experientia
Miloš V. Novotný, Francis J. Schwende, D. Wiesler, James W. Jorgenson, Marvin Carmack,
Tópico(s): Neurobiology and Insect Physiology Research
1984 - Birkhäuser | Experientia
Francis J. Schwende, James W. Jorgenson, Miloš V. Novotný,
Tópico(s): Neurobiology and Insect Physiology Research
1984 - Springer Science+Business Media | Journal of Chemical Ecology