Sergio Cruz-León, Tomáš Majtner, Patrick C. Hoffmann, Jan Philipp Kreysing, Sebastian Kehl, Maarten W. Tuijtel, Stefan L. Schaefer, Katharina Geißler, Martin Beck, Beata Turoňová, Gerhard Hummer,
Abstract Visual proteomics attempts to build atlases of the molecular content of cells but the automated annotation of cryo electron tomograms remains challenging. Template matching (TM) and methods based on machine learning detect structural signatures of macromolecules. However, their applicability remains limited in terms of both the abundance and size of the molecular targets. Here we show that the performance of TM is greatly improved by using template-specific search parameter optimization ...
Tópico(s): RNA and protein synthesis mechanisms
2024 - Nature Portfolio | Nature Communications
Günter Lehmann, Claus Schmitt, Victoria Kehl, Sebastian Schmieder, Albert Schömig,
This study was performed to elaborate an electrocardiographic (ECG) algorithm enabling assignment of an occluded coronary artery in acute myocardial infarction (AMI).In 109 patients (age, 59+/-12 years) with AMI (pain onset, 3.6+/-1.7 h), coronary angiography with PTCA/stenting of the culprit lesion was performed. The diagnosis of AMI was confirmed by emergency coronary angiography and laboratory analyses. Admission ECG parameters (amplitude of R-wave, ST-segment deviation, presence of Q-wave, deflection ...
Tópico(s): Cardiac Imaging and Diagnostics
2003 - Elsevier BV | International Journal of Cardiology
Marc Siggel, Sebastian Kehl, Klaus Reuter, Jürgen Köfinger, Gerhard Hummer,
Lipid membranes are integral building blocks of living cells and perform a multitude of biological functions. Currently, molecular simulations of cellular-scale membrane remodeling processes at atomic resolution are extremely difficult, due to their size, complexity, and the large times-scales on which these processes occur. Instead, elastic membrane models are used to simulate membrane shapes and transitions between them and to infer their properties and functions. Unfortunately, an efficiently ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2022 - American Institute of Physics | The Journal of Chemical Physics
Sven Kehl, Anna Ehard, Sebastian Berlit, Saskia Spaich, Marc Sütterlin, Jörn Siemer,
To evaluate a combination of oral misoprostol (OM) and mechanical dilation of the cervix to improve efficacy in inducing labour.This prospective, randomized study included 122 term pregnancies with an indication for induced labour. Each woman was randomly assigned to one of two groups. In the study group, a combination of OM and mechanical dilation with a double-balloon catheter for cervical ripening was used. In the control group, only OM was administered. The primary outcome measure was the rate ...
Tópico(s): Maternal and fetal healthcare
2011 - Elsevier BV | European Journal of Obstetrics & Gynecology and Reproductive Biology
Pedro Emanuel Fleitas, Sebastián Dario Kehl, Walter López, Marina Travacio, Elvia Nieves, José F. Gil, Rubén O. Cimino, Alejandro Krolewiecki,
The WHO has established a control strategy for Strongyloides stercoralis in school-aged children as well as targets and to maintain control programs for Ascaris lumbricoides, Trichuris trichiura and hookworms. For an efficient development of control programs, it is necessary to know the target countries around the world, as well as the areas within each country where efforts should be focused. Therefore, maps that provide information on the areas at risk for soil-transmitted helminth (STH) infections ...
Tópico(s): Global Maternal and Child Health
2022 - BioMed Central | Parasites & Vectors
Vadim Issakov, Sebastian Kehl-Waas, Sascha Breun,
This paper presents a new, almost fully analytical methodology for component value extraction of a double-π equivalent circuit model for three-port on-chip inductors from a given S-parameter dataset. The compact model provides an accurate fit over a wide frequency range from dc to beyond the self-resonance frequency (SRF) to a tabular input S-parameter model describing a symmetric center-tapped on-chip inductor. The input dataset may be obtained from a measurement or from an electromagnetic field ...
Tópico(s): Microwave Engineering and Waveguides
2019 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Circuits and Systems I Regular Papers
Carla Bellomo, Daniel Oscar Alonso, Tamara Ricardo, Rocío Coelho, Sebastián Dario Kehl, Natalia Períolo, Viviana Azogaray, Natalia Casas, Mariano Ottonelli, Laura Cristina Bergero, María Carolina Cudós, M. Andrea Previtali, Valeria P. Martínez,
Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and are transmitted to humans through aerosolized viral particles generated by the excretions of infected individuals. Since the first description of HPS in Argentina, new hantaviruses have been reported throughout the country, most of which are pathogenic to humans. We present here the first HPS case infected with Alto Paraguay virus reported ...
Tópico(s): Mosquito-borne diseases and control
2021 - Public Library of Science | PLoS neglected tropical diseases
Walter López, Mariano Altamiranda‐Saavedra, Sebastián Dario Kehl, Ignacio Ferro, Carla Bellomo, Valeria P. Martínez, Mario Ignacio Simoy, José F. Gil,
Abstract Background Hantavirus Pulmonary Syndrome (HPS) is a rodent-borne zoonosis in the Americas, with up to 50% mortality rates. In Argentina, the Northwestern endemic area presents half of the annually notified HPS cases in the country, transmitted by at least three rodent species recognized as reservoirs of Orthohantavirus . The potential distribution of reservoir species based on ecological niche models (ENM) can be a useful tool to establish risk areas for zoonotic diseases. Our main aim was ...
Tópico(s): Mosquito-borne diseases and control
2023 - BioMed Central | BMC Public Health
Sven Kehl, Grit Welzel, Anna Ehard, Sebastian Berlit, Saskia Spaich, Jörn Siemer, Marc Sütterlin,
A wide variety of pharmacological and mechanical methods (e.g. balloon devices) are available for inducing labour, but little information is available about the way in which women regard balloon devices. The aim of this study was to investigate women's acceptance of and satisfaction with the induction of labour by administration of oral misoprostol and the combination of that with a double-balloon device.The study included 122 women with term pregnancies who required induction of labour between August ...
Tópico(s): Global Maternal and Child Health
2013 - Elsevier BV | European Journal of Obstetrics & Gynecology and Reproductive Biology
Simon Schwunk, Nils Armbruster, Sebastian Straub, Johannes Kehl, Matthias Vetter,
The paper presents a new approach for state estimation of lithium–iron phosphate batteries. Lithium–iron phosphate/graphite batteries are very intricate in state of charge estimation since the open circuit voltage characteristic is flat and ambiguous. The characteristic is ambiguous because open circuit voltages are different if one charges or discharges the battery. These properties also hinder state of health estimation. Therefore conventional approaches like Kalman filtering which represents ...
Tópico(s): Reliability and Maintenance Optimization
2012 - Elsevier BV | Journal of Power Sources
Annemarie Kehl, M. Hiller, Fabian Hecker, Igor Tkach, Sebastian Dechert, Marina Bennati, Andreas Meyer,
Pulsed 19F ENDOR spectroscopy provides a selective method for measuring angstrom to nanometer distances in structural biology. Here, the performance of 19F ENDOR at fields of 3.4 T and 9.4 T is compared using model compounds containing one to three 19F atoms. CF3 groups are included in two compounds, for which the possible occurrence of uniaxial rotation might affect the distance distribution. At 9.4 T, pronounced asymmetric features are observed in many of the presented 19F ENDOR spectra. Data ...
Tópico(s): Advanced MRI Techniques and Applications
2021 - Elsevier BV | Journal of Magnetic Resonance
Sebastian Schulz-Stübner, Franz Kehl,
Tópico(s): Urticaria and Related Conditions
2011 - Springer Science+Business Media | Intensive Care Medicine
Sven Kehl, Jacqueline D. Ziegler, E Schleußner, Benjamin Tuschy, Sebastian Berlit, J Kirscht, Franziska A. Hägele, Christel Weiß, Jörn Siemer, Marc Sütterlin,
Objective To evaluate the efficacy of inducing labour using a double‐balloon catheter and oral misoprostol sequentially, in comparison with oral misoprostol alone. Design A multicentre randomised controlled trial. Setting Five hospitals in Germany. Population A total of 326 pregnant women with an unfavourable cervix undergoing labour induction at term. Methods Women were randomly assigned according to a computer‐generated allocation sequence to sequential use of double‐balloon catheter and oral ...
Tópico(s): Pregnancy-related medical research
2014 - Wiley | BJOG An International Journal of Obstetrics & Gynaecology
Manuel Alcaraz‐Castaño, Javier Alcolea-González, María de Andrés Herrero, Samuel Castillo‐Jiménez, Felipe Cuartero, Gloria Cuenca‐Bescós, Martin Kehl, J.A. López-Sáez, Luis Luque, Sebastián Pérez Díaz, Raquel Piqué, Mónica Ruíz Alonso, Gerd‐Christian Weniger, José Yravedra,
Abstract As the south-westernmost region of Europe, the Iberian Peninsula stands as a key area for understanding the process of modern human dispersal into Eurasia. However, the precise timing, ecological setting and cultural context of this process remains controversial concerning its spatiotemporal distribution within the different regions of the peninsula. While traditional models assumed that the whole Iberian hinterland was avoided by modern humans due to ecological factors until the retreat ...
Tópico(s): Forensic Anthropology and Bioarchaeology Studies
2021 - Nature Portfolio | Scientific Reports
Carla Bellomo, Daniel Oscar Alonso, Unai Pérez‐Sautu, Karla Prieto, Sebastián Dario Kehl, Rocío Coelho, Natalia Períolo, Nicholas Di Paola, N.M. Ferressini Gerpe, Jens H. Kuhn, Mariano Sánchez-Lockhart, Gustavo Palacios, Valeria P. Martínez,
We performed whole-genome sequencing with bait enrichment techniques to analyze Andes virus (ANDV), a cause of human hantavirus pulmonary syndrome. We used cryopreserved lung tissues from a naturally infected long-tailed colilargo, including early, intermediate, and late cell culture, passages of an ANDV isolate from that animal, and lung tissues from golden hamsters experimentally exposed to that ANDV isolate. The resulting complete genome sequences were subjected to detailed comparative genomic ...
Tópico(s): Viral Infections and Outbreaks Research
2023 - American Society for Microbiology | mSphere
Timo Kehl, Anne Bleiholder, Florian M. Rossmann, Sebastian Rupp, Janet Lei-Rossmann, Justin Lee, Walter M. Boyce, T. Winston Vickers, Kevin R. Crooks, Sue VandeWoude, Martin Löchelt,
We report two complete foamy retrovirus (FV) genomes isolated from Puma concolor, a large cat native to the Americas. Due to high overall genetic relatedness to known feline foamy viruses (FFVs), we propose the name Puma concolor FFV (FFVPc). The data confirm that felines are infected with distinct but closely related FVs.
Tópico(s): Herpesvirus Infections and Treatments
2013 - American Society for Microbiology | Genome Announcements
Arne Simon, Sebastian Völz, Katja Höfling, Alexandra Kehl, Ramona Tillman, Andreas Müller, Bernd Kupfer, Anna‐Maria Eis‐Hübinger, Michael J. Lentze, U. Bode, Oliver Schildgen,
Abstract In this short report we discuss the temporal association between an acute life threatening event (ALTE) and a RT‐PCR confirmed coronavirus HCoV‐229E infection in a 4 months old otherwise healthy infant. More detailed microbiological investigations of affected children even without apparent signs of a respiratory tract infection may help to clarify the etiology in some patients and extend our understanding of the pathogenesis. PCR‐based techniques should be utilized to increase the sensitivity ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2007 - Wiley | Pediatric Pulmonology
Sven Kehl, A. Schelkle, A. Thomas, Alexander Puhl, K. Meqdad, Benjamin Tuschy, Sebastian Berlit, Christel Weiß, Christian Bayer, Jutta Heimrich, Ulf Dammer, E Raabe, Mathias Winkler, Florian Faschingbauer, MW Beckmann, Marc Sütterlin,
ABSTRACT Objective To determine whether the amniotic fluid index (AFI) or the single deepest vertical pocket (SDP) technique for estimating amniotic fluid volume is superior for predicting adverse pregnancy outcome. Methods This was a multicenter randomized controlled trial including 1052 pregnant women with a term singleton pregnancy across four hospitals in Germany. Women were assigned randomly, according to a computer‐generated allocation sequence, to AFI or SDP measurement for estimation of amniotic ...
Tópico(s): Maternal and Perinatal Health Interventions
2015 - Wiley | Ultrasound in Obstetrics and Gynecology
Sven Kehl, A. Schelkle, A. Thomas, Alexander Puhl, K. Meqdad, Benjamin Tuschy, Sebastian Berlit, Christel Weiß, Christian Bayer, Jutta Heimrich, Ulf Dammer, E Raabe, Mathias Winkler, Florian Faschingbauer, MW Beckmann, Marc Sütterlin,
(Abstracted from Ultrasound Obstet Gynecol 2016;47:674–679) One of the important aspects of fetal well-being assessment is amniotic fluid volume, lack of which leads to oligohydramnios and consequently adverse perinatal outcomes. Amniotic fluid estimation by ultrasound can be performed by assessment of the amniotic fluid index (AFI) or the single deepest vertical pocket (SDP) technique.
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
2016 - Lippincott Williams & Wilkins | Obstetrical & Gynecological Survey
Sven Kehl, Joachim Brade, U. Schmidt, Sebastian Berlit, Michael K. Bohlmann, Marc Sütterlin, Jörn Siemer, Amadeus Hornemann,
Tópico(s): Maternal and fetal healthcare
2011 - Springer Science+Business Media | Archives of Gynecology and Obstetrics
Stefanie Jilg, Michael Rassner, Jacqueline Maier, Silvia Waldeck, Victoria Kehl, Marie Follo, Ulrike Philipp, Andreas Sauter, Katja Specht, Jan Mitschke, Thoralf Lange, Sebastian Bauer, Philipp J. Jost, Christian Peschel, Justus Duyster, Timo Gaiser, Peter Hohenberger, Nikolas von Bubnoff,
This prospective trial aimed to investigate whether tumor‐specific cKIT and PDGFRA mutations can be detected and quantified in circulating tumor (ct)DNA in patients with active GIST, and whether detection indicates disease activity. We included 25 patients with active disease and cKIT or PDGFRA mutations detected in tissue. Mutant ctDNA was detected in the peripheral blood plasma using allele‐specific ligation (L‐)PCR and droplet digital (d)PCR. CtDNA harboring tumor‐specific cKIT or PDGFRA mutations ...
Tópico(s): Sarcoma Diagnosis and Treatment
2019 - Wiley | International Journal of Cancer
Sven Kehl, Sven Eckert, Sebastian Berlit, Benjamin Tuschy, Marc Sütterlin, Jörn Siemer,
The purpose of this study was to develop new formulas for the expected fetal lung area-to-head circumference ratio in normal singleton pregnancies between 20 and 40 weeks' gestation.The lung-to-head ratio and complete fetal biometric parameters of 126 fetuses between 20 and 40 weeks' gestation were prospectively measured. The lung-to-head ratio was measured by 3 different methods (longest diameter, anteroposterior diameter, and tracing). Formulas for predicting right and left lung-to-head ratios ...
Tópico(s): Neonatal Respiratory Health Research
2013 - Wiley | Journal of Ultrasound in Medicine
Niklas Kehl, Michael Kilian, Julius Michel, Tim Wagner, Sebastian Uhrig, Alexander Brobeil, Lilli-Sophie Sester, Sven Blobner, Simon Steiger, Michael Hundemer, Niels Weinhold, Karsten Rippe, Stefan Fröhling, Stefan B. Eichmüller, Lukas Bunse, Carsten Müller‐Tidow, Hartmut Goldschmidt, Michael Platten, Marc‐Steffen Raab, Mirco Friedrich,
Multiple myeloma (MM) is a hematological malignancy originating from malignant and clonally expanding plasma cells. MM can be molecularly stratified, and its clonal evolution deciphered based on the Ig heavy and light chains of the respective malignant plasma cell clone. Of all MM subtypes, IgE type MM accounts for only <0.1% of cases and is associated with an aggressive clinical course and consequentially dismal prognosis. In such malignancies, adoptive transfer of autologous lymphocytes specifically ...
Tópico(s): T-cell and B-cell Immunology
2022 - BMJ | Journal for ImmunoTherapy of Cancer
Benjamin Tuschy, Sebastian Berlit, Simone Romero, Elena Sperk, Frederik Wenz, Sven Kehl, Marc Sütterlin,
To assess postoperative complications, clinical outcome and histological findings in patients undergoing intraoperative radiotherapy with low energy x-rays for early breast cancer. We retrospectively analysed data of 208 women who underwent intraoperative irradiation during breast conserving surgery (BCS) between 2002 and 2007. Demographic, clinical and surgical parameters as well as short-term complications within the first postoperative week and histological findings were evaluated. Toxicities ...
Tópico(s): Breast Implant and Reconstruction
2013 - BioMed Central | Radiation Oncology
Saskia Spaich, Grit Welzel, Sebastian Berlit, D Temerinac, Benjamin Tuschy, Marc Sütterlin, Sven Kehl,
Many factors affect women's satisfaction with the experience of childbirth. Some of these are known, but most have not been fully evaluated. The influence of the mode of delivery is unclear. This study investigated the extent to which satisfaction with childbirth depends on the mode of delivery, and evaluated factors determining postpartum satisfaction.Women with singleton pregnancies at term were included prospectively. After childbirth, all women meeting the inclusion criteria received a standardised ...
Tópico(s): Global Maternal and Child Health
2013 - Elsevier BV | European Journal of Obstetrics & Gynecology and Reproductive Biology
Sven Kehl, Christel Weiß, Ulf Dammer, Sebastian Berlit, Thomas Große-Steffen, Florian Faschingbauer, Marc Sütterlin, Matthias W. Beckmann, Michael Schneider,
Purpose Induction of labour for small-for-gestational-age (SGA) foetus or intrauterine growth restriction (IUGR) is common, but data are limited. The aim of this study was therefore to compare labour induction for SGA/IUGR with cases of normal foetal growth above the 10th percentile. Material and Methods This historical multicentre cohort study included singleton pregnancies at term. Labour induction for SGA/IUGR (IUGR group) was compared with cases of foetal growth above the 10th percentile (control ...
Tópico(s): Birth, Development, and Health
2019 - Thieme Medical Publishers (Germany) | Geburtshilfe und Frauenheilkunde
Sebastian Berlit, Benjamin Tuschy, Joachim Brade, Jade Mayer, Sven Kehl, Marc Sütterlin,
Objective To compare the effectiveness of self-administered 50% nitrous oxide and conventional infiltrative anaesthesia with 1% prilocaine hydrochloride in postpartum perineal repair. Study design A total of 100 women were prospectively enrolled and randomised to receive either infiltrative anaesthesia or a self-administered nitrous oxide mixture (Livopan©) for pain relief during postpartum perineal suturing. Besides data concerning anaesthesia, characteristics of patients and labour were documented ...
Tópico(s): Maternal and Perinatal Health Interventions
2013 - Elsevier BV | European Journal of Obstetrics & Gynecology and Reproductive Biology
Alessandro Potì, Martin Kehl, Manuel Broich, Yolanda Carrión Marco, Rainer Hutterer, Thalia Jentke, Jörg Linstädter, José Antonio López Sáez, Abdeslam Mikdad, Jacob Morales, Sebastián Pérez Díaz, Marta Portillo, Clemens Schmid, Paloma Vidal-Matutano, Gerd‐Christian Weniger,
With the onset of the Last Glacial Maximum (LGM), hunter-gatherers of the so-called Iberomaurusian techno-complex appeared in what is now the Mediterranean Maghreb. During a period of about seven thousand years, these groups left sandy occupation layers in a limited number of archaeological sites, while at the beginning of Greenland Interstadial (GI) 1, the sudden shift towards the deposition of shell-rich sediments and the increase in number of sites document clear changes in subsistence strategies ...
Tópico(s): Archaeological and Geological Studies
2019 - Elsevier BV | Quaternary Science Reviews
Sebastian Winkler, Sabine Barta, Victoria Kehl, Christoph Schröter, Ferdinand Wagner, Joachim Grifka, Hans Robert Springorum, Benjamin Craiovan,
Non-selective NSAIDs can cause serious gastrointestinal side-effects. Selective COX-2 blockers are a reasonable alternative for pain treatment. They do not seem to affect platelet function and consequently cause a lower perioperative blood loss than non-selective NSAIDs. This study compared etoricoxib and diclofenac during a perioperative (9 days) period after THA to investigate total blood loss and gastrointestinal tolerability. The hypothesis was that etoricoxib is superior to diclofenac.A total ...
Tópico(s): Orthopaedic implants and arthroplasty
2015 - Taylor & Francis | Current Medical Research and Opinion
Sebastian Winkler, Hans-Robert Springorum, T. Vaitl, Martin Händel, Sabine Barta, Victoria Kehl, Benjamin Craiovan, Joachim Grifka,
This study investigated whether etoricoxib (COX-II blocker) has a superior efficacy of preventing heterotopic ossification (HO) after total hip arthroplasty (THA) compared to diclofenac (non-selective NSAID).One hundred patients were included (50 in each group) in this single centre, prospective, double-blinded, randomized, controlled trial. Etoricoxib (90 mg) was administered once and diclofenac (75 mg) twice per day for a perioperative period of nine days. The incidence of HO was evaluated on radiographs ...
Tópico(s): Inflammatory mediators and NSAID effects
2016 - Springer Science+Business Media | International Orthopaedics