Produção Nacional
Revisado por pares
Clarice Heiko Muramatsu, Olga Cristina Serafim Vieira, Cirilo César Simões, Daniela Aparecida Katayama, Flávia Hiroko Nakagawa,
Este estudo tem como objetivo identificar as possíveis conseqüências da Síndrome da Tensão Pré-Menstrual na vida da mulher. Através do questionário, identificamos distúrbios relacionados a alterações físicas, emocionais e, como consequências às alterações nos relacionamentos envolvendo filho, marido/ namorado e familiar, assim como no ambiente de trabalho.
Tópico(s): Women's cancer prevention and management
2001 - UNIVERSIDADE DE SÃO PAULO | Revista da Escola de Enfermagem da USP
Produção Nacional
Revisado por pares
Grasieli de Oliveira Ramos, Juliana Cristina Porto, Daniella Serafim Couto Vieira, Filipe Modolo, Elena Riet Corrêa Rivero,
Odontogenic tumors (OTs) are lesions that develop exclusively on maxillary bones, and form a heterogeneous group. They vary from hamartomatous lesions to benign and malign tumors. Although they are rarely observed in dentistry clinics, it is extremely important for the dentist to be aware of them. The aim of this study was to investigate the incidence of odontogenic tumors diagnosed in the population of Florianópolis, Santa Catarina, Brazil. Cases of odontogenic tumors were selected from the anatomopathological ...
Tópico(s): dental development and anomalies
2014 - Brazilian Society of Dental Research | Brazilian Oral Research
Produção Nacional
Revisado por pares
Eduardo Luiz Gasnhar Moreira, Jade de Oliveira, Jean Costa Nunes, Danúbia Bonfanti Santos, Fernanda Costa Nunes, Daniella Serafim Couto Vieira, Rosa Maria Ribeiro‐do‐Valle, Fabrício A. Pamplona, Andreza Fabro de, Marcelo Farina, Roger Walz, Rui Daniel Prediger,
There is increasing evidence that hypercholesterolemia during midlife may represent a predictor of subsequent mild cognitive impairments and dementia decades later. However, the exact mechanism underlying this phenomenon remains unknown since plasmat
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2012 - IOS Press | Journal of Alzheimer s Disease
Produção Nacional
Revisado por pares
Nair Lopes, Bárbara Sousa, Diana Martins, Madalena Gomes, Daniella Serafim Couto Vieira, Luiz Alberto Veronese, Fernanda Milanezi, Joana Paredes, José Luís Costa, Fernando Schmitt,
Breast cancer is a heterogeneous disease associated with different patient prognosis and responses to therapy. Vitamin D has been emerging as a potential treatment for cancer, as it has been demonstrated that it modulates proliferation, apoptosis, invasion and metastasis, among others. It acts mostly through the Vitamin D receptor (VDR) and the synthesis and degradation of this hormone are regulated by the enzymes CYP27B1 and CYP24A1, respectively. We aimed to study the expression of these three ...
Tópico(s): Cancer Risks and Factors
2010 - BioMed Central | BMC Cancer
Produção Nacional
Revisado por pares
Aline Biaseto Bernhard, Veruska Magalhães Scabim, Marcela Pires Serafim, Alexandre Vieira Gadducci, Marco Aurélio Santo, Roberto de Cleva,
Abstract Background The body adiposity index ( BAI ) comprises a simple method for estimating body fat ( BF ) that needs to be validated in patients with severe obesity. The present study aimed to determine BAI accuracy with respect to the determination BF in patients with severe obesity. Methods A cross‐sectional prospective study comparing two methods for BF estimation was conducted in 433 patients with severe obesity between August 2012 to December 2014. BF was estimated by bioelectrical impedance analysis ( ...
Tópico(s): Cardiovascular Disease and Adiposity
2016 - Wiley | Journal of Human Nutrition and Dietetics
Produção Nacional
Revisado por pares
Anie Savi Serafim, G Moretti, Guilherme Savi Serafim, Cintia Vieira Niero, Maria Inês da Rosa, Maria Marlene de Souza Pires, Priscyla Waleska Targino de Azevedo Simões,
Introduction The aim of this study was to establish the incidence rates of congenital syphilis in the South Region of Brazil from 2001 to 2009. Methods Temporal ecological and descriptive study based on the cases recorded by the System of Information of Notifiable Diseases. Results The incidence of congenital syphilis has been increasing in the South Region of Brazil since 2004; the highest incidence rates were in women who received prenatal care (113.5 new cases per 100,000 births, p<0.001), who ...
Tópico(s): Global Maternal and Child Health
2014 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Produção Nacional
Revisado por pares
Marcelo Bianchini Teive, Ricardo Fantazzinni Russi, Daniella Serafim Couto Vieira, André Muller Teive, Aline Costa, Armando José d'Acâmpora,
Sleeve gastrectomy (SG) removes substantial part of the gastric mucosa, which produces ghrelin. This reduction is expected to force other organs, such as the duodenum, to compensate by increasing the number of ghrelin-producing cells. The purpose of this study was to evaluate whether this response occurs.Twelve adult male, Wistar rats underwent SG and were reoperated 30 or 60 days after the initial surgery. During the second surgery, a segment of the duodenum was resected to count ghrelin cells using ...
Tópico(s): Diet, Metabolism, and Disease
2012 - Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia | Acta Cirúrgica Brasileira
Eduardo Moura, Paulo Costa, D. Moura, Serafim Guimarães, Maria Augusta Vieira‐Coelho,
Higher activity of the peripheral sympathetic nervous system, accompanied by higher tyrosine hydroxylase activity is frequently and consistently reported in human essential hypertension as well as in animal models of hypertension. However, results obtained in the adrenals, particularly in young animals before the development of hypertension, are scarce and controversial. In the present study tyrosine hydroxylase activity and catecholamine content in the adrenals of spontaneously hypertensive rats ...
Tópico(s): Aldose Reductase and Taurine
2005 - Elsevier BV | Life Sciences
Produção Nacional
Revisado por pares
Diana Soares de Azevedo, Ana Cândida Serafim dos Reis, Lydia Vieira Freitas, Priscila Bomfim Costa, Patrícia Neyva da Costa Pinheiro, Ana Kelve de Castro Damasceno,
Estudo descritivo que teve por objetivo identificar o conhecimento das primíparas a respeito dos benefícios do aleitamento materno para a mãe e o recém-nascido, desenvolvido na Maternidade Escola Assis Chateaubriand — MEAC, entre os meses de novembro de 2006 e janeiro 2007. A população se constituiu de puérperas primíparas que se encontravam no alojamento conjunto da Instituição, sendo a amostra de 252 mulheres. A saúde e o valor nutricional foram os benefícios para o bebê mais citados (48,0% e 14, ...
Tópico(s): Breastfeeding Practices and Influences
2010 - UNIVERSIDADE FEDERAL DO CEARÁ | Rev Rene
Produção Nacional
Revisado por pares
Lêda Regis, Ridelane Veiga Acioli, José Constantino Silveira, Maria Alice Varjal de Melo-Santos, Wayner Vieira de Souza, Cândida Maria Nogueira Ribeiro, Juliana Carla Serafim da Silva, Antônio Miguel Vieira Monteiro, Cláudia Maria Fontes de Oliveira, Rosângela Maria Rodrigues Barbosa, Cynthia Braga, M. A. B. Rodrigues, Marilú Gomes N. M. Silva, Paulo Justiniano Ribeiro, Wagner Hugo Bonat, Líliam César de Castro Medeiros, Marília Sá Carvalho, André Freire Furtado,
Aedes aegypti has developed evolution-driven adaptations for surviving in the domestic human habitat. Several trap models have been designed considering these strategies and tested for monitoring this efficient vector of Dengue. Here, we report a real-scale evaluation of a system for monitoring and controlling mosquito populations based on egg sampling coupled with geographic information systems technology. The SMCP-Aedes, a system based on open technology and open data standards, was set up from ...
Tópico(s): Zoonotic diseases and public health
2013 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Mariza Maria Serafim Mattosinho, Denise Maria Guerreiro Vieira da Silva,
This is a qualitative assistential convergent study. Its main objective is to understand the therapeutic itinerary of adolescents with type 1 mellitus diabetes, as well as that of their families. The sample was composed of adolescents, between 15 and 25 years old, involved with a health institution in Florianópolis through the Health Care model that includes professional, family, and popular subsystems. Data were obtained through in-depth interviews and field observation of 20 people (relatives and ...
Tópico(s): Health, Nursing, Elderly Care
2007 - UNIVERSIDADE DE SÃO PAULO | Revista Latino-Americana de Enfermagem
Produção Nacional
Revisado por pares
Marlene Lourenço da Silva, João Renato Stehmann, Mateus Sá Magalhães Serafim, Valdicley Vieira Vale, Douglas Costa Gontijo, Geraldo Célio Brandão, Erna Geessien Kroon, Alaı́de Braga de Oliveira,
The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI) > 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97).
Tópico(s): Malaria Research and Control
2019 - Taylor & Francis | Natural Product Research
Produção Nacional
Revisado por pares
Marcela Pires Serafim, Marco Aurélio Santo, Alexandre Vieira Gadducci, Veruska Magalhães Scabim, Ivan Cecconello, Roberto de Cleva,
OBJECTIVE:To analyze the changes in the body composition of morbidly obese patients induced by a very lowcalorie diet.METHODS: We evaluated 120 patients selected from a university hospital.Body composition was assessed before and after the diet provided during hospitalization, and changes in weight, body mass index, and neck, waist and hip circumferences were analyzed.Bioimpedance was used to obtain body fat and fat-free mass values.The data were categorized by gender, age, body mass index and diabetes ...
Tópico(s): Bariatric Surgery and Outcomes
2019 - Elsevier BV | Clinics
Produção Nacional
Revisado por pares
Vivianne Mendes Mangueira, Tatianne Mota Batista, Monalisa Taveira Brito, Tatyanna Kélvia Gomes de Sousa, Ryldene Marques Duarte da Cruz, Renata Albuquerque de Abrantes, Robson Cavalcante Veras, Isac Almeida de Medeiros, Karina Karla de Paula Medeiros, Ana Ligia da Costa Pereira, Vanessa de Lima Serafim, Ricardo Olímpio de Moura, Marianna Vieira Sobral,
Acridine derivatives, including amsacrine, have antitumor activity. However, side effects, development of resistance and their low bioavailability, have limited their use. Herein, we described the synthesis, and evaluated the toxicity and antitumor activity of a new amsacrine analogous, the N'-(2-chloro-6-methoxy-acridin-9-yl)-2-cyano-3-(4-dimethylaminophenyl)-acrilohidrazida (ACS-AZ10).The compound was obtained in a linear pathway where the ASC-Az intermediate was obtained by coupling of 6,9-dichloro- ...
Tópico(s): Synthesis and biological activity
2017 - Elsevier BV | Biomedicine & Pharmacotherapy
Produção Nacional
Revisado por pares
Deborah Faria, José Carlos Morante‐Filho, Júlio Baumgarten, Ricardo S. Bovendorp, Eliana Cazetta, Fernanda Amato Gaiotto, Eduardo Mariano‐Neto, Marcelo Schramm Mielke, Michaele S. Pessoa, Larissa Rocha‐Santos, Alesandro Souza Santos, Leiza Aparecida Souza Serafim Soares, Daniela Custódio Talora, Emerson Monteiro Vieira, Maíra Benchimol,
The pace of deforestation in tropical forests has achieved unprecedented rates, requiring effective and achievable conservation mitigations that are also easily understood by society and policy makers. In this context, we report the outcomes from a large-scale project located in the threatened Atlantic Forest (SISBIOTA network) to understand how deforestation affects ecological patterns and processes in human-modified landscapes. In particular, we compiled data from 28 studies that evaluated habitat ...
Tópico(s): Plant and animal studies
2023 - Elsevier BV | Biological Conservation
Produção Nacional
Revisado por pares
Paulo Gonçalves de Sousa, Ana Gabrielle do Nascimento Camara, Artur Ramon Tomé Oliveira, Gabriella de Castro Lima, Gledson Vieira Lima, Lucas Pinheiro Coutinho, Jeferson Yves Nunes Holanda Alexandre, Leonardo F. Serafim, Marcos Carlos de Mattos, Norberto Vieira de Kássio Monteiro, José Cleiton Sousa dos Santos,
Eversa® Transform 2.0 is a lipase derived from Thermomyces lanuginosus produced by a genetically modified microorganism. It has a low production cost, high substrate specificity, and high catalytic activity in organic synthesis. The Taguchi method was used to evaluate the best conditions for the enzymatic esterification of glycerol with acetic acid. A yield of 84.8% was obtained, under the optimal conditions (temperature = 40 °C; molar ratio glycerol/acid = 1:1; biocatalyst = 15% w/w; time = 12.5 h). After ...
Tópico(s): Pharmacological Effects and Assays
2023 - Elsevier BV | Biochemical Engineering Journal
Produção Nacional
Revisado por pares
Sergio P. Rigonatti, Antônio de Pádua Serafim, Maria Adelaide de Freitas Caires, A. H. G. Vieira Filho, Julio Arboleda‐Flórez,
Tópico(s): Personality Disorders and Psychopathology
2006 - Elsevier BV | International Journal of Law and Psychiatry
Produção Nacional
Revisado por pares
Leiza Aparecida Souza Serafim Soares, Deborah Faria, Felipe Vélez‐García, Emerson Monteiro Vieira, Daniela Custódio Talora, Eliana Cazetta,
Habitat loss is the main driver of the loss of global biodiversity. Knowledge on this subject, however, is highly concentrated on species richness and composition patterns, with little discussion on the consequences of habitat loss for ecological interactions. Therefore, a systemic approach is necessary to maximize the success of conservation efforts by providing more realistic information about the effects of anthropogenic disturbances on natural environmental processes. We investigated the implications ...
Tópico(s): Bee Products Chemical Analysis
2015 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Marcello Imbrizi, Júlio Pinheiro Baima, Matheus Freitas Cardoso de Azevedo, Adriana Ribas Andrade, Natália Sousa Freitas Queiroz, Júlio Maria Fonseca Chebli, Liliane Andrade CHEBLI, Marjorie Argollo, Lígia Yukie Sassaki, Rogério Serafim Parra, Abel Botelho Quaresma, Andréa Vieira, Adérson Omar Mourão Cintra Damião, Antônio Carlos Moraes, Cristina Flores, Cyrla Zaltman, Eduardo García Vilela, Eloá Marussi Morsoletto, Francisco de Assis Gonçalves Filho, Francisco Guilherme Cancela e Penna, Genoile Oliveira Santana, Gilmara Pandolfo Zabot, José Miguel Luz Parente, Márcia Henriques de Magalhães Costa, Marco Zerôncio, Marta Brenner Machado, Ornella Sari Cassol, Paulo Gustavo Kotze, Renata de Sá Brito Fróes, Sender Jankiel Miszputen, Orlando Ambrogini, Rogério Saad-Hossne, Cláudio Saddy Rodrigues Coy,
Background: Inflammatory bowel disease (IBD) is an immune-mediated disorder that includes Crohn's disease (CD) and ulcerative colitis. CD is characterized by a transmural intestinal involvement from the mouth to the anus with recurrent and remitting symptoms that can lead to progressive bowel damage and disability over time. Objective: To guide the safest and effective medical treatments of adults with CD. Methods: This consensus was developed by stakeholders representing Brazilian gastroenterologists ...
Tópico(s): Pregnancy and Medication Impact
2023 - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) | Arquivos de Gastroenterologia
Produção Nacional
Revisado por pares
Juliana Carvalho Ferreira, Chung-Chou H. Chang, Bruno Adler Maccagnan Pinheiro Besen, Luiz Marcelo Sá Malbuisson, Leandro Utino Taniguchi, Pedro Vitale Mendes, Eduardo Leite Vieira Costa, Marcelo Park, Renato Daltro-Oliveira, Roberta Muriel Longo Roepke, João Manoel Silva, Maria José Carvalho Carmona, Carlos Roberto Ribeiro de Carvalho, Adriana Sayuri Hirota, Alberto Kendy Kanasiro, Alessandra Crescenzi, Amanda Coelho Fernandes, Anna Miethke-Morais, Arthur Petrillo Bellintani, Artur Ribeiro Canasiro, Bárbara Vieira Carneiro, Beatriz Keiko Zanbon, Bernardo Pinheiro de Senna Nogueira Batista, Bianca Ruiz Nicolao, Bruno Adler Maccagnan Pinheiro Besen, Bruno Biselli, Bruno Rocha de Macedo, Caio Machado Gomes De Toledo, Carlos Eduardo Pompílio, Carlos Roberto Ribeiro de Carvalho, Caroline Gomes Mól, Cassio Stipanich, Cauê Gasparotto Bueno, Cibele Larrosa Garzillo, Clarice Tanaka, Daniel Neves Forte, Daniel Joelsons, Daniele Robira, Eduardo Leite Vieira Costa, Élson Mendes da Silva, Fabiane Aliotti Regalio, Gabriela Cardoso Segura, Gustavo Brasil Marcelino, Giulia Sefrin Louro, Chung-Chou H. Chang, Isabela Argollo Ferreira, Jeison de Oliveira Gois, João Manoel Silva, José Otto Reusing, Julia Fray Ribeiro, Juliana Carvalho Ferreira, Karine Vusberg Galleti, Katia Regina da Silva, Larissa Padrão Isensee, Larissa dos Santos Oliveira, Leandro Utino Taniguchi, Leila Suemi Harima Letaif, Lígia Trombetta Lima, Lucas Yongsoo Park, Lucas Chaves, Luciana Cassimiro Nobrega, Luciana Haddad, Ludhmila Abrahão Hajjar, Luíz Marcelo Sá Malbouisson, Manuela Cristina Adsuara Pandolfi, Marcelo Park, Maria José Carvalho Carmona, Maria Castilho Prandini H De Andrade, Mariana Moreira Santos, Matheus Pereira Bateloche, Mayra Akimi Suiama, Mayron F. Oliveira, Mayson Laércio de Araújo Sousa, Michelle Louvaes, Natassja Huemer, Pedro Vitale Mendes, Paulo Ricardo Gessolo Lins, Pedro Gaspar Dos Santos, Pedro Ferreira Paiva Moreira, Renata Mello Guazzelli, Renato Batista Dos Reis, Renato Daltro De Oliveira, Roberta Muriel Longo Roepke, Rodolpho Augusto de Moura Pedro, Rodrigo Kondo, Samia Zahi Rached, Sergio Roberto Silveira Da Fonseca, Thais Sousa Borges, Thalissa Ferreira, Vilson Cobello, Vivian Vieira Tenório Sales, Willaby Serafim Cassa Ferreira,
We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic.This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the ...
Tópico(s): Long-Term Effects of COVID-19
2020 - Elsevier BV | Clinics
Produção Nacional
Revisado por pares
Serafim Florentino Neto, Ariadna Lafourcade Prada, Leonardo Domingo Rosales Achod, Heron Fernandes Vieira Torquato, Cauê Santos Lima, Edgar Julian Paredes‐Gamero, Maria Oneide Silva de Moraes, Émerson Silva Lima, Edgar Hernández Sosa, Tatiane Pereira de Souza, Jesús Rafael Rodríguez Amado,
Amyrins are triterpenes that have attractive pharmacological potential; however, their low water solubility and erratic stomach absorption hinders their use as a drug. The aim of this paper was to develop a novel α-amyrin-loaded nanocapsule for intestinal delivery and evaluate, preliminarily, its cytotoxic ability against leukemic cells. Five nanocapsule formulations were designed by the solvent displacement-evaporation method. Poly-ε-caprolactone, Eudragit® E100, and Kollicoat® Mae 100 P were used ...
Tópico(s): Natural Compounds in Disease Treatment
2021 - Elsevier BV | Biomedicine & Pharmacotherapy
Produção Nacional
Revisado por pares
Thiago DeSouza‐Vieira, Eva Iniguez, Tiago D. Serafim, Waldionê de Castro, Subir Karmakar, Maria M. Disotuar, Pedro Cecílio, Joshua R. Lacsina, Claudio Meneses, Bianca M. Nagata, Sílvia Cardoso, Daniel E. Sonenshine, Ian N. Moore, Valéria M. Borges, Ranadhir Dey, Miguel P. Soares, Hira L. Nakhasi, Fabiano Oliveira, Jesús G. Valenzuela, Shaden Kamhawi,
Hematophagous vectors lacerate host skin and capillaries to acquire a blood meal, resulting in leakage of red blood cells (RBCs) and inflammation. Here, we show that heme oxygenase-1 (HO-1), a pleiotropic cytoprotective isoenzyme that mitigates heme-mediated tissue damage, is induced after bites of sand flies, mosquitoes, and ticks. Further, we demonstrate that erythrophagocytosis by macrophages, including a skin-residing CD163+CD91+ professional iron-recycling subpopulation, produces HO-1 after bites. ...
Tópico(s): Mosquito-borne diseases and control
2020 - Cell Press | Cell Reports
Fred L. Soper, Heitor Vieira Penna, E A Cardoso, João Serafim, M. Frobisher, José Wilton Pinheiro,
Journal Article YELLOW FEVER WITHOUT AËDES AEGYPTI. STUDY OF A RURAL EPIDEMIC IN THE VALLE DO CHANAAN, ESPIRITO SANTO, BRAZIL, 1932 Get access F. L. SOPER, F. L. SOPER Search for other works by this author on: Oxford Academic PubMed Google Scholar H. PENNA, H. PENNA Search for other works by this author on: Oxford Academic PubMed Google Scholar E. CARDOSO, E. CARDOSO Search for other works by this author on: Oxford Academic PubMed Google Scholar J. SERAFIM, JR., J. SERAFIM, JR. Search for other ...
Tópico(s): History of Medicine and Tropical Health
1933 - Oxford University Press | American Journal of Epidemiology
Produção Nacional
Revisado por pares
Joel Gomes da Silva, Jonhatan Magno Norte da Silva, Lucas Gomes Miranda Bispo, Deividson Sá Fernandes de Souza, Rômulo Silva Serafim, Manoel Gerônimo Lino Torres, Wilza Karla dos Santos Leite, Elamara Marama de Araújo Vieira,
Musculoskeletal symptoms are a major occupational health problem in workers, and these can affect all professional occupations. Previous studies have proposed metrics capable of evaluating the musculoskeletal discomfort experienced by workers. However, no study has developed a metric that considers professional groups. Thus, this study aimed to develop a scale for musculoskeletal discomfort in the lower limbs to compare self-reported symptoms among education, health, and industry professionals. ...
Tópico(s): Ergonomics and Musculoskeletal Disorders
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Wen‐Wei Zhang, Subir Karmakar, Sreenivas Gannavaram, Ranadhir Dey, Patrick Lypaczewski, Nevien Ismail, Abid Siddiqui, Vahan Simonyan, Fabiano Oliveira, Iliano V. Coutinho-Abreu, Thiago DeSouza‐Vieira, Claudio Meneses, James Oristian, Tiago D. Serafim, Abu Musa, Risa Nakamura, Noushin Saljoughian, Greta Volpedo, Monika Satoskar, Sanika Satoskar, Pradeep K. Dagur, J. Philip McCoy, Shaden Kamhawi, Jesús G. Valenzuela, Shinjiro Hamano, Abhay R. Satoskar, Greg Matlashewski, Hira L. Nakhasi,
Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted by infected sand flies. Vaccination through leishmanization with live Leishmania major has been used successfully but is no longer practiced because it resulted in occasional skin lesions. A second generation leishmanization is described here using a CRISPR genome edited L. major strain (LmCen-/-). Notably, LmCen-/- is a genetically engineered centrin gene knock-out mutant strain that is antibiotic resistant marker ...
Tópico(s): Trypanosoma species research and implications
2020 - Nature Portfolio | Nature Communications
Produção Nacional
Revisado por pares
Luciana da Silva Lemos, Alessa Siqueira de Oliveira dos Santos, Ana Bárbara Freitas Rodrigues, Maria Laudelina Vieira Seródio Goulart, Luciano Grillo de Almeida, Leonardo Serafim da Silveira,
A dog with multiple infection by D. renale in the abdominal cavity presented granular peritonitis with giant cells phagocytizing D. renale eggs.Hepatic and phrenic serositis associated to numerous eggs of the parasite immersed in fibrinous process were observed.Lungs presented D. renale eggs in the parenchyma, mononucleated cell infiltrates, edema, hemorrhage, congestion, atelectasia, emphysema, and thromboembolism.D. renale eggs were detected inside the center-lobular veins, auricular cavities, ...
Tópico(s): Forensic Entomology and Diptera Studies
2010 - Chilean Society of Anatomy | International Journal of Morphology
Diana Soares de Azevedo, Ana Cândida Serafim dos Reis, Lydia Vieira Freitas, Priscila Bomfim Costa, Patrícia Neyva da Costa Pinheiro, Ana Kelve de Castro Damasceno,
This is a descriptive study that aimed to identify the primiparous mother’s knowledge about the benefits of breastfeeding for the mother and the newborn It was developed in the Maternity School Assis Chateaubriand — MEAC, between the months of November 2006 and January 2007. The population consisted of primiparous mothers who were in the room of the institution. The sample was of 252 women. Health and nutritional value are the most cited benefits for the baby (48.0% and 14.7%), and a high percentage ...
Tópico(s): Migration, Racism, and Human Rights
2012 - UNIVERSIDADE FEDERAL DO CEARÁ | Rev Rene
Produção Nacional
Revisado por pares
Antônio Edvan Camelo-Filho, André Macedo Serafim Silva, Eduardo de Paula Estephan, Antônio A. Zambon, Rodrigo Holanda Mendonça, Paulo Victor Sgobbi de Souza, Wladimir Bocca Vieira de Rezende Pinto, Acary Souza Bullé Oliveira, Iron Dangoni-Filho, Ana Flávia Pincerno Pouza, Berenice Cataldo Oliveira Valério, Edmar Zanoteli,
Myasthenia gravis (MG), an autoimmune neuromuscular disorder, may be a risk factor for severe COVID-19. We conducted an observational retrospective study with 15 consecutive adult MG patients admitted with COVID-19 at four hospitals in São Paulo, Brazil. Most patients with MG hospitalized for COVID-19 had severe courses of the disease: 87% were admitted in the intensive care unit, 73% needed mechanical ventilation, and 30% died. Immunoglobulin use and the plasma exchange procedure were safe. Immunosuppressive ...
Tópico(s): COVID-19 Clinical Research Studies
2020 - Frontiers Media | Frontiers in Neurology
Produção Nacional
Revisado por pares
Gislaine Laperuta Serafim Argentino, Flávia Neves Bueloni-Dias, Nilton José Leite, Gustavo Filipov Peres, Leonardo Vieira Elias, Vitória Cristina Bortolani, Carlos Roberto Padovani, Daniel Spadoto-Dias, Rogério Dias,
Purpose: To evaluate agreement between pre- and post-laparoscopy gynecological diagnosis in order to demonstrate the rationality of this minimally invasive technique use in gynecological propaedeutics. Methods: Retrospective chart review study conducted between March 2010 and October 2016 based on a convenience sample. 315 patients undergoing surgical laparoscopy at the Center of Gynecologic Endoscopy and Family Planning of Botucatu Medical School/UNESP. Pre- and postoperative diagnoses were compared ...
Tópico(s): Endometriosis Research and Treatment
2019 - Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia | Acta Cirúrgica Brasileira
Produção Nacional
Revisado por pares
Carlos Eduardo Ambrósio, Atanásio Serafim Vidane, Aline Fernanda de Souza, Rafael Sampaio, Fabiana Fernandes Bressan, Naira Caroline Godoy Pieri, Daniele dos Santos Martins, Flávio Vieira Meirelles, María Angélica Miglino,
Abstract: Amnion-derived mesenchymal stem cells (AMSCs) are multipotent cells with an enhanced ability to differentiate into multiple lineages. AMSCs can be acquired through noninvasive methods, and therefore are exempt from the typical ethical issues surrounding stem cell use. The objective of this study was to isolate and characterize AMSCs from a cat amniotic membrane for future application in regenerative medicine. The cat AMSCs were harvested after mechanical and enzymatic digestion of amnion. ...
Tópico(s): Organ and Tissue Transplantation Research
2014 - Dove Medical Press | Stem Cells and Cloning Advances and Applications