Les C. Cwynar, Glen M. MacDonald,
... Drexler, Christian Drosten, Emmanuel R. Nakouné, Eric M. Leroy, Serge Morand, Michelle L. Baker Bat Distribution Size or ...
Tópico(s): Forest ecology and management
1987 - University of Chicago Press | The American Naturalist
Romain Guyot, Florent Lefebvre-Pautigny, Christine Tranchant‐Dubreuil, Michel Rigoreau, Perla Hamon, Thierry Leroy, Serge Hamon, Valérie Poncet, Dominique Crouzillat, Alexandre de Kochko,
Coffee trees (Rubiaceae) and tomato (Solanaceae) belong to the Asterid clade, while grapevine (Vitaceae) belongs to the Rosid clade. Coffee and tomato separated from grapevine 125 million years ago, while coffee and tomato diverged 83-89 million years ago. These long periods of divergent evolution should have permitted the genomes to reorganize significantly. So far, very few comparative mappings have been performed between very distantly related species belonging to different clades. We report the ...
Tópico(s): Plant Virus Research Studies
2012 - BioMed Central | BMC Genomics
Stéphanie Leroy, Serge X. Cohen, Catherine Verna, Bernard Gratuze, Florian Téreygeol, P. Fluzin, Loïc Bertrand, P. Dillmann,
The medieval iron market in Ariège (French Pyrenees) is characterised by its complexity leading to many questions regarding the ore used in relation to the artefacts encountered in archaeological settings. Despite the conclusive study of the treaty that regulated iron vs. coal exchanges from the 14th to the 19th c. by Verna et al., many questions remain unanswered concerning provenance and circulation of ores and products. Based on a combination of trace elemental analysis and multivariate statistical ...
Tópico(s): Archaeology and ancient environmental studies
2011 - Elsevier BV | Journal of Archaeological Science
Gaël Darren Maganga, Mathieu Bourgarel, Peter Vallo, Thierno D. Dallo, Carine Ngoagouni, Jan Felix Drexler, Christian Drosten, Emmanuel Nakouné, Eric M. Leroy, Sergé Morand,
The rising incidence of emerging infectious diseases (EID) is mostly linked to biodiversity loss, changes in habitat use and increasing habitat fragmentation. Bats are linked to a growing number of EID but few studies have explored the factors of viral richness in bats. These may have implications for role of bats as potential reservoirs. We investigated the determinants of viral richness in 15 species of African bats (8 Pteropodidae and 7 microchiroptera) in Central and West Africa for which we provide ...
Tópico(s): Zoonotic diseases and public health
2014 - Public Library of Science | PLoS ONE
José Bustamante-Porras, Claudine Campa, Valérie Poncet, Michel Noirot, Thierry Leroy, Serge Hamon, Alexandre de Kochko,
Tópico(s): Plant Stress Responses and Tolerance
2007 - Springer Science+Business Media | Molecular Genetics and Genomics
Audrey Sirvent, Anthony Boureux, Valérie Simon, Cédric Leroy, Serge Roche,
The cytoplasmic tyrosine kinase Src has been implicated in signal transduction induced by growth factors and integrins. Src also shows oncogenic activity when deregulated. Accumulating evidence indicates that the tyrosine kinase Abl is an important substrate for Src signalling in normal cells. Here we show that Abl is also required for Src-induced transformation of mouse fibroblasts. Abl does not mediate tyrosine phosphorylation of Stat3 and Shc, two important regulators of Src oncogenic activity. ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2007 - Springer Nature | Oncogene
Brian J. LeRoy, Serge G. Lemay, Jing Kong, Cees Dekker,
Tópico(s): Carbon Nanotubes in Composites
2004 - Nature Portfolio | Nature
Brian J. LeRoy, Serge G. Lemay, Jing Kong, Cees Dekker,
We have performed low-temperature STM measurements on single-wall carbon nanotubes that are freely suspended over a trench. The nanotubes were grown by CVD on a Pt substrate with predefined trenches etched into it. Atomic resolution was obtained on the freestanding portions of the nanotubes. Spatially resolved spectroscopy on the suspended portion of both metallic and semiconducting nanotubes was also achieved, showing a Coulomb-staircase behavior superimposed on the local density of states. The ...
Tópico(s): Force Microscopy Techniques and Applications
2004 - American Institute of Physics | Applied Physics Letters
Jing Kong, Brian J. LeRoy, Serge G. Lemay, Cees Dekker,
We have developed a fabrication process for incorporating a gate electrode into suspended single-walled carbon nanotube structures for scanning tunneling spectroscopy studies. The nanotubes are synthesized by chemical vapor deposition directly on a metal surface. The high temperature (800°C) involved in the growth process poses challenging issues such as surface roughness and integrity of the structure which are addressed in this work. We demonstrate the effectiveness of the gate on the freestanding ...
Tópico(s): Force Microscopy Techniques and Applications
2005 - American Institute of Physics | Applied Physics Letters
Anaïs Pujals, Giuliana Amaddeo, Claire Castain, Paulette Bioulac‐Sage, Philippe Compagnon, Jessica Zucman‐Rossi, Daniel Azoulay, Karen Leroy, Élie Serge Zafrani, Julien Caldéraro,
Potential conflict of interest: Nothing to report. To the Editor: Bile duct adenomas (BDA) are rare and benign intrahepatic biliary proliferations of uncertain pathogenesis. They are usually small in size ( 3 3a BDA wt 4 62 M Atypical focal nodular hyperlasia NASH 2 4a BDA V600E 4b BDA wt 5 67 M ICC None 3 5a BDA V600E 5b BDA V600E 5c BDA V600E 5d ICC V600E 6 57 M HCC NASH/Alcohol 1 6a BDA wt 7 76 M ICC None >3 7a BDA wt 7b ICC wt 8 74 M Biliary cyst None 1 8a BDA V600E 9 69 M ICC None 2 9a BDA V600E ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2014 - Lippincott Williams & Wilkins | Hepatology
Nathalie Boddaert, Kim‐Hanh Le Quan Sang, Agnès Rötig, Anne Leroy‐Willig, Serge Gallet, Françis Brunelle, Daniel Sidi, Jean‐Christophe Thalabard, Arnold Münnich, Z. Ioav Cabantchik,
Genetic disorders of iron metabolism and chronic inflammation often evoke local iron accumulation. In Friedreich ataxia, decreased iron-sulphur cluster and heme formation leads to mitochondrial iron accumulation and ensuing oxidative damage that primarily affects sensory neurons, the myocardium, and endocrine glands. We assessed the possibility of reducing brain iron accumulation in Friedreich ataxia patients with a membrane-permeant chelator capable of shuttling chelated iron from cells to transferrin, ...
Tópico(s): Mitochondrial Function and Pathology
2007 - Elsevier BV | Blood
Simon Lacroix, Dominique Egrise, Gaëtan Van Simaeys, Gilles Doumont, Michel Monclus, Félicie Sherer, T. Herbaux, D Leroy, Serge Goldman,
We used [ 18 F]‐4‐fluorobenzamido‐ N ‐ethylamino‐maleimide ([ 18 F]‐FBEM) to radiolabel cells ex vivo for in vivo positron emission tomography (PET) in order to assess cell trafficking in mice. In contrast to commonly used imaging agents, [ 18 F]‐FBEM forms a covalent bond with thiol groups present on the cells surface. The stability of the probe in aqueous medium was tested at different pH values and cross‐experiment showed that thiol‐labeling efficiency was retained (at least) up to pH 9. The labeling procedure ...
Tópico(s): Lanthanide and Transition Metal Complexes
2013 - Hindawi Publishing Corporation | Contrast Media & Molecular Imaging
Maximilien Vermandel, Clément Dupont, F. Lecomte, Henri‐Arthur Leroy, Constantin Tuleasca, Serge Mordon, Constantinos G. Hadjipanayis, Nicolas Reyns,
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. The unfavorable prognosis despite maximal therapy relates to high propensity for recurrence. Thus, overall survival (OS) is quite limited and local failure remains the fundamental problem. Here, we present a safety and feasibility trial after treating GBM intraoperatively by photodynamic therapy (PDT) after 5-aminolevulinic acid (5-ALA) administration and maximal resection.Ten patients with newly diagnosed GBM were enrolled and ...
Tópico(s): Photodynamic Therapy Research Studies
2021 - Springer Science+Business Media | Journal of Neuro-Oncology
Maximilien Vermandel, Mathilde Quidet, Anne‐Sophie Vignion‐Dewalle, Henri‐Arthur Leroy, B. Leroux, Serge Mordon, Nicolas Reyns,
There is currently no therapy that prevents high-grade glioma recurrence. Thus, these primary brain tumors have unfavorable outcomes. Recently, 5-ALA photodynamic therapy (PDT) has been proposed to delay relapse and is highly expected to have potential synergistic effects with the current standard of care. However, PDT treatment delivery needs to be optimized by evaluating the impact of both the number of fractions and the light power used. Previous studies have reported MRI examination-based outcomes ...
Tópico(s): Photodynamic Therapy Research Studies
2018 - Elsevier BV | Photodiagnosis and Photodynamic Therapy
François‐Xavier Mahon, Sandrine Hayette, Valérie Lagarde, Françis Belloc, Béatrice Turcq, Franck E. Nicolini, Coralie Bélanger, Paul W. Manley, Cédric Leroy, Gabriel Étienne, Serge Roche, Jean‐Max Pasquet,
Abstract Targeting the tyrosine kinase activity of Bcr-Abl is an attractive therapeutic strategy in chronic myeloid leukemia (CML) and in Bcr-Abl–positive acute lymphoblastic leukemia. Whereas imatinib, a selective inhibitor of Bcr-Abl tyrosine kinase, is now used in frontline therapy for CML, second-generation inhibitors of Bcr-Abl tyrosine kinase such as nilotinib or dasatinib have been developed for the treatment of imatinib-resistant or imatinib-intolerant disease. In the current study, we generated ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2008 - American Association for Cancer Research | Cancer Research
Vincent Leroy, Frédérique Monier, Serge P. Bottari, Candice Trocmé, Nathalie Stürm, Marie‐Noëlle Hilleret, Françoise Morel, Jean–Pierre Zarski,
OBJECTIVES Histological examination of liver biopsy is currently required in the management of patients with chronic hepatitis C. Our aim was to evaluate the diagnostic utility of a panel of circulating markers in detecting the stage of fibrosis. METHODS One hundred and ninety four-patients who had undergone a percutaneous liver biopsy before antiviral treatment, and 194 age- and sex-matched healthy subjects were studied. Serum levels of hyaluronate, procollagen type III N-terminal peptide (PIIINP), ...
Tópico(s): Liver Disease and Transplantation
2004 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Stéphanie Leroy, Christophe Duperray, Sergé Morand,
Phytoparasitic nematodes are devastating pests that cause high yield losses in agriculture. A parasitic nematode injects effector molecules into root cells to manipulate the root cell processes. In response, plants activate their immune response against nematodes infection by recognizing the invasion through several different and complementary systems. Genomic techniques have identified putative nematode effector molecules that alter plant cell biology and induce giant cell formation. The nematode ...
Tópico(s): Plant Parasitism and Resistance
2003 - Elsevier BV | Molecular and Biochemical Parasitology
Pierre Leroy, D. Decolin, Serge Nicolas, Philippe Archimbault, Alain Nicolas,
Residues of two antibacterial agents, cephalexin and colistin, co-administered by intramuscular injection to calves, were quantified in four different tissues (muscle, fat, liver and kidney) by column switching HPLC and by a microbiological method. For cephalexin assay, tissue samples with cephradin as internal standard were homogenized in a 5% trichloroacetic acid solution and filtrates were injected onto a concentration precolumn filled with LiChroprep RP-18 (25-40 microns). A clean-up step was ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
1989 - Elsevier BV | Journal of Pharmaceutical and Biomedical Analysis
Joël Leroy, L. Choplin, Serge Kaliaguine,
Abstract Detailed rheological study was made for sixteen pyrolytic wood derived oils provided by different laboratories and obtained from a wide range of liquefaction processes. Molecular characterization of these oils has been performed through gel permeation chromatography (GPC) and intrinsic viscosity [η] measurements. All pyrolytic wood derived oils exhibit an essentially Newtonian behavior in the range of shear rate examined (10-1 to 103s-1). The variation of viscosity with temperature follows ...
Tópico(s): Petroleum Processing and Analysis
1988 - Taylor & Francis | Chemical Engineering Communications
Stéphanie Leroy, Salah Bouamer, Sergé Morand, Mireille Fargette,
tion. Representative specimens from the samples of each species were handpicked, fixed in hot 4% formaldehyde, transferred to anhydrous glycerol and mounted on Cobb slides to confirm identification. Morphology and morphometrics of specimens were compared to information in the literature and/or direct observations on reference material in collections. Haploid genome sizes and standard deviations are shown in Table 1. For seven taxa, standard deviations were less than 10% of the corresponding genome ...
Tópico(s): Parasite Biology and Host Interactions
2007 - Brill | Nematology
Gaëlle Leroy, J.F. Grongnet, Serge Mabeau, Daniel Le Corre, Céline Baty-Julien,
The artichoke (Cynara scolymus L.) accumulates about 50-70 g kg(-1) of its fresh weight as inulin-type fructan. Inulin fermentation increases gas production and thereby provokes intestinal discomfort in some people. The present research focuses on the changes in carbohydrate composition occurring in artichoke heads during storage under different conditions (18 degrees C, 4 degrees C and 4 degrees C under polypropylene film packing).Carbohydrate content and composition were determined by anion-exchange ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2010 - Wiley | Journal of the Science of Food and Agriculture
Pierre Colin, P. Nevoux, Mohamad Feras Marqa, F. Auger, Xavier Leroy, Arnauld Villers, Philippe Puech, Serge Mordon, Nacim Betrouni,
To examine the feasibility and reproducibility of laser interstitial thermotherapy (LITT) as a minimally invasive method for the treatment of prostate cancer.Heterotopic tumours of prostatic adenocarcinoma (Dunning R3327-AT2) were induced in 10 male Copenhagen rats. After preoperative magnetic resonance imaging (MRI), a 10-mm cylindrical diffusing fibre developed by our research department was inserted under ultrasonographic guidance into the tumour. LITT was performed with a 980-nm diode laser (power ...
Tópico(s): Laser-induced spectroscopy and plasma
2011 - Wiley | BJU International
Didier Leroy, Fiona Macintyre, Adoke Yeka, Serge Ouoba, Aïssata Barry, Ghyslain Mombo‐Ngoma, Jacques Mari Ndong Ngomo, Rosauro Varo, Yannelle Dossou, Antoinette Tshefu, Tran Thanh Duong, Bui Quang Phuc, Bart Laurijssens, Roland Klopper, Nimol Khim, Eric Legrand, Didier Ménard,
Abstract Background Today, the development of new and well-tolerated anti-malarial drugs is strongly justified by the emergence of Plasmodium falciparum resistance. In 2014–2015, a phase 2b clinical study was conducted to evaluate the efficacy of a single oral dose of Artefenomel (OZ439)–piperaquine (PPQ) in Asian and African patients presenting with uncomplicated falciparum malaria. Methods Blood samples collected before treatment offered the opportunity to investigate the proportion of multidrug ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2019 - BioMed Central | Malaria Journal
L.Y. Zhang, Christophe Bounaix Morand Du Puch, C. Dalmay, Aurélie Lacroix, Alaeddine Landoulsi, Jonathan Leroy, Carole Mélin, Fabrice Lalloué, Serge Battu, Christophe Lautrette, Stéphanie Giraud, A. Bessaudou, P. Blondy, Marie‐Odile Jauberteau, Arnaud Pothier,
This paper illustrates the potential of microwave frequencies for biological analysis and cell discrimination. Microwave electric fields have the capability to penetrate inside cells and interact with their intracellular content. Hence, measuring cell electrical properties in the Gigahertz frequency spectrum may allow distinguishing intracellular differences between cells without requiring any labeling or denaturation. Here, we present how microwave resonators can be used as biosensors to measure ...
Tópico(s): Microwave and Dielectric Measurement Techniques
2014 - Elsevier BV | Sensors and Actuators A Physical
Audrey Sirvent, Cédric Leroy, Anthony Boureux, Valérie Simon, Serge Roche,
The Src-like adaptor protein (SLAP) belongs to the subfamily of adapter proteins that negatively regulate cellular signalling initiated by tyrosine kinases. SLAP has a unique, myristylated N-terminus, followed by SH3 and SH2 domains with high homology to Src family tyrosine kinases (SFK) and a unique C-terminal tail, which is important for c-Cbl binding. We have previously shown that SLAP negatively regulates platelet-derived growth factor (PDGF)-induced mitogenesis in fibroblasts and we now report ...
Tópico(s): Cell Adhesion Molecules Research
2008 - Springer Nature | Oncogene
Anaïs Marie, Julien Leroy, Morgane Darricau, Serge Alfos, Véronique De Smedt‐Peyrusse, Emmanuel Richard, Sylvie Vancassel, Clémentine Bosch‐Bouju,
Background The mechanisms leading to a loss of dopaminergic (DA) neurons from the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) have multifactorial origins. In this context, nutrition is currently investigated as a modifiable environmental factor for the prevention of PD. In particular, initial studies revealed the deleterious consequences of vitamin A signaling failure on dopamine-related motor behaviors. However, the potential of vitamin A supplementation itself to prevent neurodegeneration ...
Tópico(s): Regulation of Appetite and Obesity
2022 - Frontiers Media | Frontiers in Nutrition
Henri‐Arthur Leroy, Maximilien Vermandel, J.-P. Lejeune, Serge Mordon, Nicolas Reyns,
High‐grade gliomas represent a widely heterogeneous group of tumors, the most frequent of which is glioblastoma multiforme. Its annual incidence has risen over the last decades, particularly amongst elderly people. The actual standards of care allow for a 15‐month median survival rate for WHO grade IV gliomas. As recurrence occurs in more than 85% of patients at the surgical margins, the initial resection extent is a cornerstone of disease control. Fluorescence guided resection (FGR) aims at increasing ...
Tópico(s): Photodynamic Therapy Research Studies
2015 - Wiley | Lasers in Surgery and Medicine
Cécile Coulon‐Leroy, Brigitte Charnomordic, Marie Thiollet‐Scholtus, Serge Guillaume,
These three volumes (CCIS 442, 443, 444) constitute the proceedings of the 15th International Conference on Information Processing and Management of Uncertainty in Knowledge-Based Systems, IPMU 2014,
Tópico(s): Semantic Web and Ontologies
2014 - Springer Science+Business Media | Communications in computer and information science
Candice Trocmé, Valériane Leroy, Nathalie Stürm, Marie‐Noëlle Hilleret, Serge P. Bottari, Françoise Morel, Jean–Pierre Zarski,
Summary. We have recently described a fibrosis index combining serum procollagen type III N‐terminal peptide (PIIINP) and matrix metalloproteinase 1 (MMP‐1) concentrations for evaluating the amount of liver fibrosis in chronic hepatitis C patients. The aims of the present study were to validate this score in another cohort of patients and to assess its variations along those of TIMP‐1, hyaluronic acid (HA) and MMP‐9 during antiviral treatment. Seventy‐nine patients treated by interferon‐alpha and ribavirin ...
Tópico(s): Systemic Lupus Erythematosus Research
2006 - Wiley | Journal of Viral Hepatitis
Alice Guyard, Alice Boyez, Anaïs Pujals, Cyrielle Robe, Jeanne Tran Van Nhieu, Yves Allory, Julien Moroch, Odette Georges, Jean‐Christophe Fournet, Elie‐Serge Zafrani, Karen Leroy,
Tópico(s): Genetic factors in colorectal cancer
2017 - Springer Science+Business Media | Virchows Archiv