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Artigo Revisado por pares

Sergi Ferré, Roberto Rimondini, Patrizia Popoli, Rosaria Reggio, Antonella Pèzzola, Anita C. Hansson, Annica Andersson, Kjell Fuxé,

Abstract Adenosine A 1 receptors antagonistically and specifically modulate the binding and functional characteristics of dopamine D 1 receptors. In the striatum this interaction seems to take place in the GABAergic strionigro‐strioentopeduncular neurons, where both receptors are colocalized. D 1 receptors in the strionigro‐strioentopeduncular neurons are involved in the increased striatal expression of immediate‐early genes induced by the systemic administration of psychostimulants and D 1 receptor ...

Tópico(s): Receptor Mechanisms and Signaling

1999 - Wiley | European Journal of Neuroscience

Artigo Acesso aberto Revisado por pares

Sergi Arfelis, Roberto Aguado, Didem Civancik-Uslu, Pere Fullana–i–Palmer, M. Àngels Pèlach, Quim Tarrés, Marc Delgado‐Aguilar,

Cellulose micro- and nanofibers (CNFs) are commonly regarded as "greener" than petro-based materials. The high energy input that their production still demands, along with the use of chemicals or heat in some pretreatments, asks for a critical view. This paper attempts a life cycle assessment of CNFs produced from bleached hardwood kraft pulp via three different pre-treatments before mechanical homogenization. First, a fully mechanical route, based on a Valley beating pre-treatment. Second, an enzymatic ...

Tópico(s): Electrospun Nanofibers in Biomedical Applications

2023 - Elsevier BV | The Science of The Total Environment

Artigo Acesso aberto Revisado por pares

Sergi Gallego, Roberto Fernández, Andrés Márquez, Manuel Ortuño, Cristian Neipp, Michael R. Gleeson, John T. Sheridan, Augusto Beléndez,

Photopolymers as recording media are widely used in optical applications. In such materials, changes in the phase of the transmittance function are generated during exposure due to refractive index and thickness modulations. These changes arise primarily as a consequence of photopolymerization and mass transport processes. Characterizing polymers' performance, for example, quantifying the value of monomer diffusion, is therefore very important. Applying index matching, the volume and surface optical ...

Tópico(s): Photonic and Optical Devices

2015 - Optica Publishing Group | Optics Letters

Artigo Acesso aberto Revisado por pares

Ricardo Gonçalves, Sergi Rima, Roberto Magueta, Pedro Pinho, Ana Collado, Apostolos Georgiadis, Jimmy Hester, Nuno Borges Carvalho, Manos M. Tentzeris,

This paper presents the design of low-cost, conformal UHF antennas and RFID tags on two types of cork substrates: natural cork and agglomerate cork. Such RFID tags find an application in wine bottle and barrel identification, and in addition, they are suitable for numerous antenna-based sensing applications. This paper includes the high-frequency characterization of the selected cork substrates considering the anisotropic behavior of such materials. In addition, the variation of their permittivity ...

Tópico(s): Plant Surface Properties and Treatments

2015 - IEEE Sensors Council | IEEE Sensors Journal

Artigo Acesso aberto Revisado por pares

Arnau Hervera, Sergi Leánez, Roberto Motterlini, Olga Pol,

Abstract Background: The administration of µ-opioid receptors (MOR) and δ-opioid receptors (DOR) as well as cannabinoid-2 receptor (CB2R) agonists attenuates neuropathic pain. We investigated if treatment with two carbon monoxide-releasing molecules (CORM-2 and CORM-3) or an inducible heme oxygenase inducer (cobalt protoporphyrin IX, CoPP) could modulate the local and systemic effects and expression of MOR, DOR, and CB2R during neuropathic pain. Methods: In C57BL/6 mice, at 10 days after the chronic ...

Tópico(s): Cannabis and Cannabinoid Research

2013 - Lippincott Williams & Wilkins | Anesthesiology

Artigo Revisado por pares

Sergi Barrera‐Ochoa, Roberto Vélez, Alfonso Rodríguez‐Baeza, Josep M. Bergua-Domingo, Jorge Knörr, Francisco Soldado,

Through an anatomical review, the aim of this study is to define the ulnar periosteal branches of the posterior interosseous vessels (PIV). In addition, we report the clinical utility of a vascularized ulnar periosteal pedicled flap (VUPPF), supplied by the investigated PIV, in a complex case of radial nonunion.Ten upper limbs latex colored from fresh human cadavers were used. Branches of the PIV were dissected under 2.5× loupe magnification, noting the periosteal, muscular, and cutaneous branches ...

Tópico(s): Bone fractures and treatments

2017 - Wiley | Microsurgery

Artigo Revisado por pares

Luisa Leolini, Marco Moriondo, Gianni Fila, Sergi Costafreda-Aumedes, Roberto Ferrise, Marco Bindi,

Viticulture is a worldwide agricultural sector with a relevant economic importance, especially in regions where the climate and environmental conditions meet requirements for the production of high quality wines. The impact of climate change combined with the increased frequency of extreme events predicted for the next future has already shown its potential detrimental effects on viticulture suitability, but few studies currently explored the effect of long-term climate change and extreme events ...

Tópico(s): Fermentation and Sensory Analysis

2017 - Elsevier BV | Field Crops Research

Artigo Acesso aberto

Carolina Soriano‐Tárraga, Eva Giralt‐Steinhauer, Marina Mola-Caminal, Rosa Maria Vivanco‐Hidalgo, Ángel Ois, Ana Rodríguez-Campello, Elisa Cuadrado‐Godia, Sergi Sayols-Baixeras, Roberto Elosúa, Jaume Roquer, Jordi Jiménez-Conde,

Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference between biological age and actual chronological age would indicate an individual's level of aging. Our aim was to determine the biological age of ischemic stroke patients and compare their aging with controls of the same chronological age. A total of 123 individuals, 41 controls ...

Tópico(s): Intergenerational Family Dynamics and Caregiving

2016 - Impact Journals LLC | Aging

Artigo Acesso aberto Revisado por pares

Carolina Soriano‐Tárraga, Jordi Jiménez-Conde, Eva Giralt‐Steinhauer, Marina Mola-Caminal, Rosa Maria Vivanco‐Hidalgo, Ángel Ois, Ana Rodríguez-Campello, Elisa Cuadrado‐Godia, Sergi Sayols-Baixeras, Roberto Elosúa, Jaume Roquer,

Type 2 diabetes mellitus (DM) is an established risk factor for a wide range of vascular diseases, including ischemic stroke (IS). Glycated hemoglobin A1c (HbA1c), a marker for average blood glucose levels over the previous 12 weeks, is used as a measure of glycemic control and also as a diagnostic criterion for diabetes (HbA1c levels ≥ 6.5%). Epigenetic mechanisms, such as DNA methylation, may be associated with aging processes and with modulation of the risk of various pathologies, such as DM. Specifically, ...

Tópico(s): Genetic Syndromes and Imprinting

2015 - Oxford University Press | Human Molecular Genetics

Artigo Revisado por pares

Lucia Manganaro, Valeria Vinci, Silvia Bernardo, Paola Storelli, Eliana Fuggetta, Paolo Sollazzo, Adele Ticino, Maria Eleonora Sergi, Roberto Brunelli, Pierluigi Benedetti Panici, Maria Grazia Porpora,

Purpose To assess the diagnostic accuracy of 3.0T magnetic resonance imaging (MRI) in assessing the involvement of uterosacral ligaments (USLs) in deep infiltrating endometriosis (DIE). Methods Between July 2010 and July 2012, 42 women, aged between 19 and 45 years (mean age 28 years), with a diagnosis of cystic ovarian endometriosis and scheduled for laparoscopic treatment, underwent pre-operative 3.0-T MRI examination. USL was considered normal when it was not visible or when it was thin and regular. ...

Tópico(s): Endometrial and Cervical Cancer Treatments

2013 - SAGE Publishing | Journal of Endometriosis and Pelvic Pain Disorders

Artigo Revisado por pares

S. Fargion, Franco Bissoli, Anna Ludovica Fracanzani, E Suigo, Consolato Sergi, Emanuela Taioli, Roberto Ceriani, Valeria Dimasi, Alberto Piperno, Maurizio Sampietro, G. Fiorelli,

Genetic hemochromatosis and α1–antitrypsin (AAT) deficiency are frequent in white populations. Conflicting data on the association of the two conditions and on the severity of the disease in those in whom these disorders coexist have emerged from analyses of small numbers of patients. To determine if the frequency of AAT deficiency is increased in genetic hemochromatosis, we characterized this protein by isoelectric focusing and DNA analysis in 115 Italian patients with the disease and 290 controls. ...

Tópico(s): Hemoglobinopathies and Related Disorders

1996 - Lippincott Williams & Wilkins | Hepatology

Artigo Revisado por pares

Sandro Pignata, Giovanni Scambia, Clorinda Schettino, Laura Arenare, Carmela Pisano, Davide Lombardi, Ugo De Giorgi, Claudia Andreetta, Saverio Cinieri, Carmine De Angelis, Domenico Priolo, Cláudia Casanova, Marta Rosati, Filippo Greco, Elena Zafarana, Ilaria Schiavetto, Serafina Mammoliti, Sabrina Chiara Cecere, Vanda Salutari, Simona Scalone, Alberto Farolfi, Marilena Di Napoli, Domenica Lorusso, Piera Gargiulo, Daniela Califano, Daniela Russo, Anna Spina, Rossella De Cecio, Paolo Chiodini, Francesco Perrone, Valentina Accinno, Chiara Altavilla, Claudia Andreetta, Giovanna Antonelli, Laura Arenare, Grazia Artioli, Francesco Avola, Bonifacio Barbara, Valentina Barbato, Michele Bartoletti, Simona Bevilacqua, Roberto Bordonaro, Oriana Borghese, Gaetano Buonfanti, Daniela Califano, Floriana Camarda, Giuliana Canzanella, Maria Rita Carbone, Maria Rita Carbone, G Stella, Cláudia Casanova, Chiara Cassani, Fabrizio Castagna, Monica Cattaneo, Sabrina Chiara Cecere, Paolo Chiodini, M. Cinefra, Saverio Cinieri, Nicoletta Colombo, Serena Corsetti, Monia Dall’Agata, Maria Rosaria D’Amico, Gennaro Daniele, Carmine De Angelis, Rossella De Cecio, Ugo De Giorgi, Elvira De Marino, Giovanni De Matteis, Sabino De Placido, Gabriella Del Bene, Antonia Del Giudice, Francesca Del Monte, Michele Del Sesto, Marilena Di Napoli, Maddalena Donini, Giuliana Drudi, G Falcone, Alberto Farolfi, Adolfo Favaretto, Giulia Ferrera, Manuela Florio, Valeria Forestieri, Maria Stella Gallo, Ciro Gallo, Piera Gargiulo, Francesca Garibaldi, Fabiana Gerevini, Viola Ghizzoni, Maria Olga Giganti, Anna Gimigliano, Elena Giudice, Nicoletta Gnocchi, Adriano Gravina, Filippo Greco, Stefano Greggi, Maria Laura Iaia, Annalisa Ilardi, Gelsomina Iovine, Gabriella Ippoliti, Giulia Irollo, Ilenia Isidori, Mariateresa Lapresa, G. Lavenia, Davide Lombardi, Laura Longhitano, Domenica Lorusso, Bortot Lucia, Gabriella Luzi, Serafina Mammoliti, Sara Mariano, Valentina Marino, Giovanna Marrapese, Marilena Martino, Roberta Matocci, E. Mazzoni, Daniela Mercuri, Maria Mirto, Giovanna Mollo, A. Montinaro, Marta Moscatelli, Anna Maria Mosconi, Lucia Musacchio, Nicoletta Nanni, Pamela Natalucci, Milena S. Nicoloso, Michele Orditura, Gabriella Maria Parma, Rodolfo Passalacqua, Michela Pelone, Maria Teresa Perri, Francesco Perrone, Bruno Perrucci, Alessandra Piancastelli, Maria Carmela Piccirillo, Antonio Piccolo, Sandro Pignata, Carmela Pisano, Domenico Priolo, Stefania Rapisardi, Giorgia Ravaglia, Teresa Ribecco, Caterina Ricci, Marianna Roccio, Fiorella Romano, Marta Rosati, Daniela Russo, Vanda Salutari, Daniela Sambataro, Alfonso Savio, Ada Sbriglia, Cono Scaffa, Simona Scalone, Giovanni Scambia, Clorinda Schettino, Ilaria Schiavetto, Concetta Sergi, Francesca Sgandurra, Roberto Sorio, Anna Spina, Stefano Stabile, Gianna Tabaro, Margherita Tambaro, Stefano Tamberi, Angelica Tecchiato, Ángela Maria Trujillo, Eleonora Zaccarelli, Elena Zafarana,

Summary Background Adding immunotherapy to first-line chemotherapy might improve outcomes for patients with advanced or recurrent endometrial cancer. We aimed to compare carboplatin and paclitaxel versus avelumab plus carboplatin and paclitaxel as first-line treatment with avelumab given concurrent to chemotherapy and as maintenance after the end of chemotherapy. Methods MITO END-3 is an open-label, randomised, controlled, phase 2 trial conducted at 31 cancer institutes, hospitals, and universities in ...

Tópico(s): Colorectal and Anal Carcinomas

2023 - Elsevier BV | The Lancet Oncology

Revisão Acesso aberto Revisado por pares

Ana Lúcia Faria, J. Latorre, Mónica Silva Cameirão, Sergi Bermúdez i Badia, Roberto Lloréns,

A systematic review was conducted to examine the state of the literature regarding using ecologically valid virtual environments and related technologies to assess and rehabilitate people with Acquired Brain Injury (ABI).

Tópico(s): Older Adults Driving Studies

2023 - Frontiers Media | Frontiers in Psychology

Artigo Revisado por pares

Anna Rita Fetoni, Aldo Ferraresi, Carmelo La Greca, Davide Rizzo, Bruno Sergi, Giuseppe Tringali, Roberto Piacentini, Diana Troiani,

Idebenone, a synthetic analogue of coenzyme Q, attenuates noise-induced hearing loss by virtue of its antioxidant properties. This study involves a guinea pig model of acoustic trauma where the effectiveness of idebenone is analyzed in comparison with Vitamin E (α-tocopherol) that exhibits a potent antioxidant activity in the inner ear. Idebenone and vitamin E were injected intraperitoneally 1 h before noise exposure and once daily for three days; functional and morphological studies were then carried ...

Tópico(s): Olfactory and Sensory Function Studies

2008 - Lippincott Williams & Wilkins | Neuroreport

Artigo Acesso aberto Revisado por pares

Alessandro Sergi, Gabriel Hanna, Roberto Grimaudo, A. Messina,

Many open quantum systems encountered in both natural and synthetic situations are embedded in classical-like baths. Often, the bath degrees of freedom may be represented in terms of canonically conjugate coordinates, but in some cases they may require a non-canonical or non-Hamiltonian representation. Herein, we review an approach to the dynamics and statistical mechanics of quantum subsystems embedded in either non-canonical or non-Hamiltonian classical-like baths which is based on operator-valued ...

Tópico(s): Quantum chaos and dynamical systems

2018 - Multidisciplinary Digital Publishing Institute | Symmetry

Artigo Revisado por pares

Sergi Ferré, Patrizia Popoli, Roberto Rimondini, Rosaria Reggio, Ján Kehr, Kjell Fuxé,

There is experimental evidence for the existence of interactions between metabotropic glutamate (mGlu), adenosine and dopamine receptors in the striatum. In membrane preparations from rat striatum the group I and II mGlu receptor agonist 1-aminocyclopentane-1S-3R-dicarboxylic acid (1S-3R-ACPD) was found to modulate the binding characteristics of D2 receptors in a similar manner as the A2A receptor agonist 2-[p-(2-carboxyethyl)phenthylamino]-5′-N-ethylcarboxamidoadenosine (CGS 21680), with a significant ...

Tópico(s): Receptor Mechanisms and Signaling

1999 - Elsevier BV | Neuropharmacology

Artigo Acesso aberto Revisado por pares

Arnau Hervera, Sergi Leánez, Roger Negrete, Roberto Motterlini, Olga Pol,

Background Carbon monoxide (CO) synthesized by heme oxygenase 1 (HO-1) exerts antinociceptive effects during inflammation but its role during neuropathic pain remains unknown. Our objective is to investigate the exact contribution of CO derived from HO-1 in the modulation of neuropathic pain and the mechanisms implicated. Methodology/Principal Findings We evaluated the antiallodynic and antihyperalgesic effects of CO following sciatic nerve injury in wild type (WT) or inducible nitric oxide synthase ...

Tópico(s): Pain Mechanisms and Treatments

2012 - Public Library of Science | PLoS ONE

Artigo Revisado por pares

C. Voz, Joaquim Puigdollers, J.M. Asensi, Sergi Galindo, S. Cheylan, Roberto Pacios, Pablo Ortega, R. Alcubilla,

This work studies the charge carrier collection efficiency in organic bulk-heterojunction solar cells based on polymer:fullerene blends. An equivalent circuit with a specific recombination term is proposed to describe the behavior of this type of devices. It is experimentally shown that this recombination term determines the slope of the current–voltage characteristic at the short-circuit condition. The variation of this dynamic resistance with the light intensity can be interpreted considering ...

Tópico(s): Semiconductor materials and interfaces

2013 - Elsevier BV | Organic Electronics

Artigo Revisado por pares

Manuel López‐Cano, José António Pereira, Sergi Mojal, Roberto Lozoya, Maite Quiles, M.A. Arbós, Manel Armengol,

<b><i>Purpose:</i></b> To assess the mental effort and physical discomfort of placement of a prosthetic mesh into the abdominal cavity with single-incision laparoscopic surgery (SILS) or multi-port laparoscopic access for incisional ventral hernia repair. <b><i>Methods:</i></b> A total of 10 surgeons with previous experience in conventional laparoscopic surgery performed four surgical tasks through a multi-port laparoscopic access and a SILS access in a ...

Tópico(s): Hernia repair and management

2012 - Karger Publishers | European Surgical Research

Artigo Revisado por pares

Roberto Rimondini, Sergi Ferré, Lydia Giménez‐Llort, Sven Ove Ögren, Kjell Fuxé,

The effects of the systemic (i.p.) administration of the selective adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) and the selective adenosine A2A receptor agonist sodium 2-p-carboxyethyl)phenylamino-5′-N-carboxamidoadenosine (CGS 21680) on different dopamine receptor agonist-induced behaviours were studied in the male rat. CGS 21680 (1 μmol/kg), but not CPA, was found to counteract the stereotypies induced by the non-selective dopamine receptor agonist apomorphine (0.25 mg/kg s.c.). Low ...

Tópico(s): Neurotransmitter Receptor Influence on Behavior

1998 - Elsevier BV | European Journal of Pharmacology

Artigo Acesso aberto Revisado por pares

Roberto Rimondini, Sergi Ferré, Sven Ove Ögren, Kjell Fuxé,

The systemic intraperitoneal (i.p.) administration of the adenosine A2A agonist CGS 21680 was found to dose-dependently antagonize spontaneous and amphetamine-induced (1 mg/kg i.p.) motor activity with similar ED50 values (about 0.2 mg/kg). The ratios between the ED50 values for induction of catalepsy and for antagonizing amphetamine-induced motor activity for CGS 21680, haloperidol, and clozapine were 12, 2, and > 30, respectively. Furthermore, CGS 21680 was comparably much stronger than haloperidol ...

Tópico(s): Pharmacological Receptor Mechanisms and Effects

1997 - Springer Nature | Neuropsychopharmacology

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Pedro M. Raposeiro, Armand Hernández, Sergi Pla‐Rabès, Vítor Gonçalves, Roberto Bao, Alberto Sáez, Timothy M. Shanahan, Mario Benavente, Erik J. de Boer, Nora Richter, Verónica Gordon, Helena Marques, Pedro M. Sousa, M. Souto, Miguel G. Matias, Nicole Aguiar, Cátia Lúcio Pereira, Catarina Ritter, María Jesús Rubio, Marina Salcedo, David Vázquez‐Loureiro, Olga Margalef, Linda Amaral‐Zettler, Ana C. Costa, Yongsong Huang, Jacqueline F. N. van Leeuwen, Pere Masqué, Ricardo Prego, Ana Carolina Ruíz-Fernández, Joan-Albert Sánchez-Cabeza, Ricardo M. Trigo, Santiago Giralt,

Significance We use a diverse set of lake and landscape proxy indicators to characterize initial human occupation and its impacts on the Azores Archipelago. The occupation of these islands began between 700 and 850 CE, 700 years earlier than suggested by documentary sources. These early occupations caused widespread ecological and landscape disturbance and raise doubts about the islands' presumed pristine nature during Portuguese arrival. The earliest explorers arrived at the end of the early Middle ...

Tópico(s): Archaeology and ancient environmental studies

2021 - National Academy of Sciences | Proceedings of the National Academy of Sciences

Artigo Acesso aberto Revisado por pares

Roberto Fernández, Sergi Gallego, Andrés Márquez, Jorge Francés, Francisco J. Martínez-Guardiola, Inmaculada Pascual, Augusto Beléndez,

Holographic polymer dispersed liquid crystals (HPDLCs) are the result of the optimization of the photopolymer fabrication techniques. They are made by recording in a photopolymerization induced phase separation process (PIPS) in which the liquid crystal molecules diffuse to dark zones in the diffraction grating originated. Thanks to the addition of liquid crystal molecules to the composition, this material has a dynamic behavior by reorientation of the liquid crystal molecules applying an electrical ...

Tópico(s): Advanced Optical Imaging Technologies

2018 - Elsevier BV | Optical Materials

Artigo Acesso aberto Revisado por pares

Roberto Fernández, Sergi Gallego, Andrés Márquez, Jorge Francés, Víctor Navarro‐Fuster, Inmaculada Pascual,

Photopolymers can be appealing materials for diffractive optical elements fabrication. In this paper, we present the recording of diffractive lenses in PVA/AA (Polyvinyl alcohol acrylamide) based photopolymers using a liquid crystal device as a master. In addition, we study the viability of using a diffusion model to simulate the lens formation in the material and to study the influence of the different parameters that govern the diffractive formation in photopolymers. Once we control the influence ...

Tópico(s): Advanced Optical Imaging Technologies

2016 - Optica Publishing Group | Optics Express

Artigo Acesso aberto Revisado por pares

Roberto Fernández, Sergi Gallego, Víctor Navarro‐Fuster, Cristian Neipp, Jorge Francés, Sandra Fenoll, Inmaculada Pascual, Augusto Beléndez,

Photopolymers are appealing materials for many optical applications.For most of them, shrinkage plays an important role in the final properties of the display, especially in holographic data storage applications.In this paper, we demonstrate that to quantify correctly the shrinkage, it is mandatory to measure the angle of propagation for both diffracted orders ± 1, so that an accurate value of the grating vector can be calculated.Experimental evidence from three different photopolymers supports this ...

Tópico(s): Optical Coatings and Gratings

2016 - Optica Publishing Group | Optical Materials Express

Artigo Acesso aberto Revisado por pares

S. Pernigo, Atsushi Fukuzawa, Amy E. M. Beedle, Mark Holt, Adam Round, Alessandro Pandini, Sergi Garcia-Manyes, Mathias Gautel, Roberto A. Steiner,

The sarcomeric cytoskeleton is a network of modular proteins that integrate mechanical and signaling roles. Obscurin, or its homolog obscurin-like-1, bridges the giant ruler titin and the myosin crosslinker myomesin at the M-band. Yet, the molecular mechanisms underlying the physical obscurin(-like-1):myomesin connection, important for mechanical integrity of the M-band, remained elusive. Here, using a combination of structural, cellular, and single-molecule force spectroscopy techniques, we decode ...

Tópico(s): Cellular Mechanics and Interactions

2016 - Elsevier BV | Structure