Nagore I. Marín‐Ramos, Carmen Piñar, Henar Vázquez‐Villa, Mar Martı́n-Fontecha, Ángel González, Ángeles Canales, Sergio Algar, Paloma P. Mayo, Jesús Jiménez‐Barbero, Consuelo Gajate, Faustino Mollinedo, Leonardo Pardo, Silvia Ortega‐Gutiérrez, Alma Viso, María L. López-Rodrı́guez,
Despite more than three decades of intense effort, no anti-Ras therapies have reached clinical application. Contributing to this failure has been an underestimation of Ras complexity and a dearth of structural information. In this regard, recent studies have revealed the highly dynamic character of the Ras surface and the existence of transient pockets suitable for small-molecule binding, opening up new possibilities for the development of Ras modulators. Herein, a novel Ras inhibitor (compound 12) ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2016 - Wiley | Chemistry - A European Journal
Walter L. Henry, Arthur W. Nienhuis, Michael Wiener, Denis R. Miller, Virginia C. Canale, Sergio Piomelli,
The heart was evaluated by echocardiography in 56 patients at risk for myocardial iron deposition. Fifty-four had congenital anemia for which they required repeated transfusions, and two had primary hemochromatosis. The data, plotted according to one of three functions of the body surface area, were compared to values obtained in 105 normal subjects whose age spanned a similar range. Left ventricular wall thickness, transverse dimension and mass, as well as left atrial transverse dimension, were ...
Tópico(s): Blood properties and coagulation
1978 - Elsevier BV | The American Journal of Medicine
Amed Gallegos-Tabanico, Jorge Jimenez Canale, Sergio G. Hernandez-Leon, Alexel Burgara-Estrella, José Carmelo Encinas, Jose A. Sarabia-Sainz,
An electrochemical sensor was fabricated for the rapid and simple detection of enrofloxacin (EF). Modification of screen-printed gold electrodes (SPE) with molecularly imprinted polymers (MIPs) allowed the detection of enrofloxacin by square wave voltammetry (SWV), measuring the oxidation peak at +0.9 V. The detection principle of molecularly imprinted polymers (MIPs) is based on the formation of binding sites with affinities and specificities comparable with those of natural antibodies. The detection ...
Tópico(s): Electrochemical Analysis and Applications
2022 - Multidisciplinary Digital Publishing Institute | Chemosensors
Enrique Rodilla, María D. López-Carmona, Xavier Cortés, Lidia Cobos-Palacios, Sergio Canales, Carmen Busca, Samara Campos Escudero, Manuel Rubio‐Rivas, Jesús Díez‐Manglano, Santiago J. Freire Castro, Nuria Vázquez Piqueras, Elisabeth Mateo Sanchis, Paula M. Pesqueira-Fontán, Jeffrey Óskar Magallanes Gamboa, Andrés González García, Víctor Madrid Romero, Lara Tamargo Chamorro, Julio González Moraleja, Javier Villanueva Martínez, Amara González Noya, Ana Suárez-Lombraña, Anyuli Gracia Gutiérrez, Manuel Lorenzo López Reboiro, José Manuel Ramos, Ricardo Gómez‐Huelgas,
Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included ...
Tópico(s): Long-Term Effects of COVID-19
2020 - Lippincott Williams & Wilkins | Hypertension
Freddy Canales-Ide, Sergio Zubelzu, Leonor Rodríguez‐Sinobas,
Tópico(s): Urban Heat Island Mitigation
2019 - Elsevier BV | Journal of Environmental Management
Produção Nacional
Revisado por pares
Maria Cristina Canale Rappussi, Sérgio Florentino Pascholati, Eliane Aparecida Benato, Patrícia Cia,
Citrus fruits are affected by the black spot disease caused by Guignardia citricarpa. Resistance induction is an alternative control measure and chitosan exhibits potential as resistance inducer. The effect of chitosan on G. citricarpa was evaluated in vitro and in 'Valencia' oranges. Citrus fruit were immersed into different chitosan concentrations. Chitosan (2%), combined with or without thiabendazole and the citric acid was also investigated. All the chitosan concentrations inhibited G. citricarpa ...
Tópico(s): Postharvest Quality and Shelf Life Management
2009 - Instituto de Tecnologia do Paraná (Tecpar) | Brazilian Archives of Biology and Technology
Daniel A. Segovia-Cardozo, Leonor Rodríguez‐Sinobas, Freddy Canales-Ide, Sergio Zubelzu,
Hydrologic processes acting on catchments are complex and variable, especially in mountain basins due to their topography and specific characteristics, so runoff simulation models and water management are also complex. Nevertheless, model parameters are usually estimated on the basis of guidelines from user manuals and literature because they are not usually monitored, due to the high cost of conventional monitoring systems. Within this framework, a new and promising generation of low-cost sensors ...
Tópico(s): Soil Moisture and Remote Sensing
2021 - Multidisciplinary Digital Publishing Institute | Water
Laura Carrillo, Edurne Baroja‐Fernández, Begoña Renau‐Morata, Francisco José Muñoz, Javier Canales, Sergio Ciordia, Lu Yang, Ángela María Sánchez‐López, Sergio G. Nebauer, Mar G. Ceballos, Jesús Vicente‐Carbajosa, R.V. Molina, Javier Pozueta‐Romero, Joaquı́n Medina,
Introduction Cycling Dof transcription factors (CDFs) have been involved in different aspects of plant growth and development. In Arabidopsis and tomato, one member of this family (CDF1) has recently been associated with the regulation of primary metabolism and abiotic stress responses, but their roles in crop production under open field conditions remain unknown. Methods In this study, we compared the growth, and tuber yield and composition of plants ectopically expressing the CDF1 gene from Arabidopsis ...
Tópico(s): Potato Plant Research
2023 - Frontiers Media | Frontiers in Plant Science
Valentina Dichiarante, Maria Isabel Martinez Espinoza, Lara Gazzera, Maja Vuckovac, Mika Latikka, Gabriella Cavallo, Giuseppina Raffaini, Reinier Oropesa‐Nuñez, Claudio Canale, Silvia Dante, Sergio Marras, Riccardo Carzino, Mirko Prato, Robin H. A. Ras, Pierangelo Metrangolo,
Perfluorocarbons (PFCs) have proven to be very efficient in building up omniphobic surfaces because of the peculiar properties of fluorine atoms. However, due to their environmental impact and bioaccumulative potential, perfluorinated surfactants with chains longer than six carbon atoms have been banned, and other alternatives had to be found. Herein, we demonstrate the possibility to build omniphobic self-assembled monolayers (SAMs) using a multibranched fluorinated thiol (BRFT) bearing ultrashort ...
Tópico(s): Gas Dynamics and Kinetic Theory
2018 - American Chemical Society | ACS Sustainable Chemistry & Engineering
Sergio Canales Vergara, Enrique Barra Almagiá,
El objetivo del presente estudio fue examinar las relaciones de la autoeficacia y el apoyo social percibido con la adherencia terapeutica en pacientes diabeticos tipo II. Se estudiaron 118 pacientes de ambos sexos, de entre 35 y 64 anos, de la ciudad de Concepcion (Chile), quienes respondieron la Escala de Autoeficacia Generalizada y el Cuestionario de Apoyo Social Percibido. La adherencia se midio a traves de dos indicadores: el autorreporte de ingestion de medicamentos y el nivel de compensacion ...
Tópico(s): Nursing care and research
2014 - Universidad Veracruzana | Psicología y Salud
Heidi S. Erickson, Paul S. Albert, John W. Gillespie, Benjamin S. Wallis, Jaime Rodriguez‐Canales, W. Marston Linehan, Sergio González, Alfredo Velasco, Rodrigo Chuaqui, Michael R. Emmert‐Buck,
Gene expression measurement techniques such as quantitative reverse transcriptase (qRT)-PCR require a normalization strategy to allow meaningful comparisons across biological samples. Typically, this is accomplished through the use of an endogenous housekeeping gene that is presumed to show stable expression levels in the samples under study. There is concern regarding how precisely specific genes can be measured in limited amounts of mRNA such as those from microdissected (MD) tissues. To address ...
Tópico(s): RNA Research and Splicing
2007 - Elsevier BV | Laboratory Investigation
Ana Mejía Canales, Sergio Franco Maass, Ángel Rolando Endara Agramont, Víctor Ávila-Akerberg,
La mayor diversidad florística de los bosques templados se encuentra en el componente herbáceo y arbustivo del sotobosque, en estos, la flora adquiere gran importancia ecológica y funcional. Los procesos esenciales del ciclo de nutrientes y la trayectoria sucesional, dependen directamente de la vegetación del sotobosque. Por ello, es necesario realizar la caracterización florística de estas comunidades y conocer su diversidad. En este estudio se determinó la composición y estructura de las especies ...
Tópico(s): Scarabaeidae Beetle Taxonomy and Biogeography
2018 - | Madera y Bosques
Mauricio Canales, Sergio Lobos, Rafael Vicuña,
Ceriporiopsis subvermispora is a white-rot basidiomycete that produces several isoenzymes of manganese peroxidase (MnP· ). A cDNA of one of them (MnP13-1) has been isolated and sequenced. The deduced aminoacid sequence shows about 60% similarity with the MnPs from Phanerochaete chrysosporium . Based on the crystal structures of MnP and lignin peroxidase (LiP) from P. chrysosporium , and of a peroxidase from Arthromyces ramosus (ARP), we have modeled by homology the three dimensional structure of MnP13-1 using ...
Tópico(s): Microbial Natural Products and Biosynthesis
1998 - Elsevier BV | Electronic Journal of Biotechnology
Yenniffer Ávalos, Jimena Canales, Roberto Bravo, Alfredo Criollo, Sergio Lavandero, Andrew F. G. Quest,
Autophagy is a highly regulated catabolic process that involves lysosomal degradation of proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis and reduction of metabolic stress. Problems in the execution of this process are linked to different pathological conditions, such as neurodegeneration, aging, and cancer. Many of the proteins that regulate autophagy are either oncogenes or tumor suppressor proteins. Specifically, tumor suppressor genes that negatively ...
Tópico(s): Calcium signaling and nucleotide metabolism
2014 - Hindawi Publishing Corporation | BioMed Research International
Romina Canales, Magdalena Espino, Sergio Pasini, María Fernanda Silva,
Phenolic compounds in NADES bioextracts can be sustainably and accurately determined combining chemometrics and green metrics.
Tópico(s): Chemistry and Chemical Engineering
2021 - Royal Society of Chemistry | Analytical Methods
Mauricio Canales, Sergio Lobos, Rafael Vicuña,
Tópico(s): Chromium effects and bioremediation
1998 - Elsevier BV | Electronic Journal of Biotechnology
José Domínguez-Figueroa, Laura Carrillo, Begoña Renau‐Morata, Lu Yang, Rosa-V Molina, Daniel Marino, Javier Canales, Martin Weih, Jesús Vicente‐Carbajosa, Sergio G. Nebauer, Joaquı́n Medina,
Nitrate is an essential macronutrient and a signal molecule that regulates the expression of multiple genes involved in plant growth and development. Here, we describe the participation of Arabidopsis DNA binding with one finger (DOF) transcription factor CDF3 in nitrate responses and shows that CDF3 gene is induced under nitrate starvation. Moreover, knockout cdf3 mutant plants exhibit nitrate-dependent lateral and primary root modifications, whereas CDF3 overexpression plants show increased biomass ...
Tópico(s): Plant Stress Responses and Tolerance
2020 - Frontiers Media | Frontiers in Plant Science
José L. Tella, Antonela Canale, Martina Carrete, Pablo F. Petracci, Sergio M. Zalba,
How birds adapt to urban life is a key question in evolutionary and conservation biology since urbanisation is one of the major causes of habitat loss worldwide. Some species are able to deal with these anthropogenic changes but a shortage of nesting sites may preclude them from breeding in cities. We conducted a baseline survey of the cliff-nesting burrowing parrot Cyanoliseus patagonus around Bahía Blanca (Argentina), estimating a minimum total of 1,361 pairs breeding at 24 sites (colonies) in 2013. ...
Tópico(s): Crime Patterns and Interventions
2014 - Spanish Ornithological Society | Ardeola
Daniel A. Segovia-Cardozo, Leonor Rodríguez‐Sinobas, Andrés Dı́ez Herrero, Sergio Zubelzu, Freddy Canales-Ide,
Tipping bucket rain gauges (TBR) are widely used worldwide because they are simple, cheap, and have low-energy consumption. However, their main disadvantage lies in measurement errors, such as those caused by rainfall intensity (RI) variation, which results in data underestimation, especially during extreme rainfall events. This work aims to understand these types of errors, identifying some of their causes through an analysis of water behavior and its effect on the TBR mechanism when RI increases. ...
Tópico(s): Soil Moisture and Remote Sensing
2021 - Multidisciplinary Digital Publishing Institute | Water
Manuel Valenzuela, Paulina Cerda-Opazo, Steffen Backert, María Fernanda González, Nicolás Carrasco-Véliz, Carla Jorquera-Cordero, Sergio Wehinger, Jimena Canales, Denisse Bravo, Andrew F. G. Quest,
Chronic Helicobacter pylori infection increases the risk of gastric cancer and induction of hypoxia-induced factor (HIF), which is frequently associated with the development and progression of several types of cancer. We recently showed that H. pylori activation of the PI3K-AKT-mTOR pathway in gastric cells increased HIF-1α expression. Here, we identified the H. pylori virulence factor responsible for HIF-1α induction. A mutant of the H. pylori 84-183 strain was identified with reduced ability to ...
Tópico(s): Galectins and Cancer Biology
2019 - Multidisciplinary Digital Publishing Institute | Cancers
Freddy Canales-Ide, Sergio Zubelzu, Daniel A. Segovia-Cardozo, Leonor Rodríguez‐Sinobas,
This paper presents a novel approach to assess spatial and temporal irrigation performance in urban parks and can assist park manager/operator decisions in irrigation management. First, irrigation needs are estimated by traditional irrigation scheduling and the irrigation zones with similar water needs that share the same electric valve (hydrozones) are identified. Then, irrigation performance is calculated using the relative water supply (RWS) indicator and mapped (GIS software). This approach can ...
Tópico(s): Irrigation Practices and Water Management
2022 - Multidisciplinary Digital Publishing Institute | Remote Sensing
Begoña Renau‐Morata, R.V. Molina, Eugenio G. Minguet, Jaime Cebolla‐Cornejo, Laura Carrillo, Raúl Martí, Victor García‐Carpintero, Eva Jiménez-Benavente, Lu Yang, Joaquı́n Cañizares, Javier Canales, Joaquı́n Medina, Sergio G. Nebauer,
The development of high nitrogen use efficiency (NUE) cultivars under low N inputs is required for sustainable agriculture. To this end, in this study, we analyzed the impact of long-term suboptimal N conditions on the metabolome and transcriptome of tomato to identify specific molecular processes and regulators at the organ scale. Physiological and metabolic analysis revealed specific responses to maintain glutamate, asparagine, and sucrose synthesis in leaves for partition to sustain growth, while ...
Tópico(s): Plant Stress Responses and Tolerance
2021 - Multidisciplinary Digital Publishing Institute | Agronomy
Cosme Alvarado‐Esquivel, Antonio Sifuentes-Álvarez, Sergio Guadalupe Narro-Duarte, Sergio Estrada-Martínez, Juan Humberto Díaz-García, Oliver Liesenfeld, Sergio Martínez‐García, Arturo Canales-Molina,
Toxoplasma gondii (T. gondii) infection in pregnant women represents a risk for congenital disease. There is scarce information about the epidemiology of T. gondii infection in pregnant women in Mexico. Therefore, we sought to determine the prevalence of T. gondii infection and associated socio-demographic, clinical and behavioural characteristics in a population of pregnant women of Durango City, Mexico.Three hundred and forty three women seeking prenatal care in a public hospital of Durango City ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
2006 - BioMed Central | BMC Infectious Diseases
Andrea Albera, Andrea Canale, Marco Boldreghini, Sergio Lucisano, Giuseppe Riva, Roberto Albera,
Contralateral delayed endolymphatic hydrops (CDEH) is a clinical entity characterized by fluctuating low frequency hearing loss and/or vertigo, mimicking Ménière's disease (MD), that manifests after the appearance of severe non-hydropic hearing loss (NHHL) at the other ear.
Tópico(s): Ophthalmology and Eye Disorders
2021 - Elsevier BV | Journal of Otology
María José García‐Jiménez, Sergio Gil‐Caballero, Ángeles Canales, Jesús Jiménez‐Barbero, José L. de Paz, Pedro M. Nieto,
FGF-1 is a potent mitogen that, by interacting simultaneously with Heparan Sulfate Glycosaminoglycan HSGAG and the extracellular domains of its membrane receptor (FGFR), generates an intracellular signal that finally leads to cell division. The overall structure of the ternary complex Heparin:FGF-1:FGFR has been finally elucidated after some controversy and the interactions within the ternary complex have been deeply described. However, since the structure of the ternary complex was described, not ...
Tópico(s): Connective tissue disorders research
2017 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Maria Cristina Canale, Eliane Aparecida Benato, Patrícia Cia, Marinéia L. Haddad, Sérgio Florentino Pascholati,
Black spot, caused by Guignardia citricarpa, is one of the main diseases affecting citrus fruits. UV-C irradiation is known to have potential to be used as an alternative method to supplement or replace the use of fungicides, especially because it promotes resistance against pathogens. The aim of this work was to evaluate the in vitro effects of UV-C irradiation on G. citricarpa development and on the control of black spot in postharvest orange. Additionally, changes in skin color of the fruit as ...
Tópico(s): Banana Cultivation and Research
2011 - Springer Science+Business Media | Tropical Plant Pathology
Annely M. Richardson, Karen Woodson, Yonghong Wang, Jaime Rodriguez‐Canales, Heidi S. Erickson, Michael A. Tangrea, Kristian Novakovic, Sergio González, Alfredo Velasco, Ernest S. Kawasaki, Michael R. Emmert‐Buck, Rodrigo Chuaqui, Audrey Player,
Characterization of gene expression profiles in tumor cells and the tumor microenvironment is an important step in understanding neoplastic progression. To date, there are limited data available on expression changes that occur in the tumor-associated stroma as either a cause or consequence of cancer. In the present study, we employed a 54,000 target oligonucleotide microarray to compare expression profiles in the 4 major components of the microenvironment: tumor epithelium, tumor-associated stroma, ...
Tópico(s): Cancer-related molecular mechanisms research
2007 - Lippincott Williams & Wilkins | Diagnostic Molecular Pathology
Beatriz Sánchez‐Espiridión, Carlos Montalbán, Angel Alfonso Velarde López, Javier Menárguez, P. Sabín, C Ruiz-Marcellán, Andrés López, Rafael Ramos, José Rodríguez, A. Alonso Cánovas, Carmen Camarero, Miguel Canales, Javier Alves, Reyes Arranz, Agustín Acevedo, Antonio Salar, Sérgio Serrano, Águeda Bas, José M. Moraleda, Pedro Sánchez‐Godoy, Fernando Burgos, C Rayón, Manuel Fresno, J García Laraña, Mónica García‐Cosío, Carlos Santonja, J. López, Marta Llanos, Manuela Mollejo, Joaquín González‐Carreró, Ana Isabel Marín, Jerónimo Forteza, Ramón García‐Sánz, José Francisco Tomás, Manuel M. Morente, Miguel Á. Piris, Juan F. Garcı́a,
Abstract Despite improvement in the treatment of advanced classical Hodgkin lymphoma, approximately 30% of patients relapse or die as result of the disease. Current predictive systems, determined by clinical and analytical parameters, fail to identify these high-risk patients accurately. We took a multistep approach to design a quantitative reverse-transcription polymerase chain reaction assay to be applied to routine formalin-fixed paraffin-embedded samples, integrating genes expressed by the tumor ...
Tópico(s): Molecular Biology Techniques and Applications
2010 - Elsevier BV | Blood
Gabriel Bayá, Eduardo Canale, Sergio Nesmachnow, Franco Robledo, Pablo Sartor,
This article introduces a Mixed-Integer Linear Programming model for cost optimization in multi-product multi-line production scheduling. This model considers discrete time windows and includes realistic constraints. The NP completeness of the problem is proven. A novel scheme based on embedding bounds is applied to speed up convergence. The model is tested on 16 input configurations of a real case study from the top Uruguayan grain production facility. The numerical results show that the model ...
Tópico(s): Advanced Control Systems Optimization
2022 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Daniel García-Gallardo, Francisco Aguilar Guevara, César Canales, Sergio Moreno, Claudio Carpio,
We assessed the effects of variable durations of food availability on an interval time-place learning task. 3 pigeons were exposed to a task in which food could be obtained for responses in one of four feeders according to an RI 25 s during 3 min, after which, food could be obtained on a different feeder according to the same schedule. The correct feeder changed following a fixed sequence that was repeated four times throughout the session. After 50 training sessions, an Open Hopper Test was conducted, ...
Tópico(s): Cognitive and developmental aspects of mathematical skills
2020 - Elsevier BV | Behavioural Processes