Marion Recher, Alejandro P. Barboza, Zhu-Hong Li, Melina Galizzi, Mariana Ferrer‐Casal, Sergio H. Szajnman, Roberto Docampo, Silvia N.J. Moreno, Juan B. Rodríguez,
As part of our efforts aimed at searching for new antiparasitic agents, 2-alkylmercaptoethyl-1,1-bisphosphonate derivatives were synthesized and evaluated against Trypanosoma cruzi, the etiologic agent of Chagas disease, and Toxoplasma gondii, the responsible agent for toxoplasmosis. Many of these sulfur-containing bisphosphonates were potent inhibitors against the intracellular form of T. cruzi, the clinically more relevant replicative form of this parasite, and tachyzoites of T. gondii targeting ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2012 - Elsevier BV | European Journal of Medicinal Chemistry
D. Egas, Sahar Azarkamand, C. Casals, Sergio Ponsá, Laia Llenas, Joan Colón,
Abstract Purpose Despite the industrial and scientific acceptance of life cycle assessment (LCA) to determine the environmental performance of products, none of the existing information on LCA provides explicit and clear recommendations on how to apply it when evaluating bio-based fertilizer (BBF) production systems. This situation affects the reliability of the results and causes confusion among practitioners, technology developers, and other stakeholders. Here, we first present the practitioners’ ...
Tópico(s): Wastewater Treatment and Reuse
2023 - Springer Science+Business Media | The International Journal of Life Cycle Assessment
Jordi Domènech-Casal, Sergio Roberto Rivera,
Tópico(s): Diffusion Coefficients in Liquids
1983 - De Gruyter | Zeitschrift für Physikalische Chemie
Juan Ruiz‐Bañobre, María C. Areses-Manrique, Joaquín Mosquera, Alexandra Cortegoso, Francisco J. Afonso-Afonso, Noemí de Dios-Álvarez, Natalia Fernández Núñez, Cristina Azpitarte-Raposeiras, Margarita Amenedo, Lucía Santomé, José Luis Fírvida-Pérez, Rosario Garcı́a-Campelo, Jorge García, Joaquín Casal‐Rubio, Sergio Vázquez‐Estévez,
The lung immune prognostic index (LIPI) has been proposed as a new categorical blood-based biomarker to select advanced non-small cell lung cancer (NSCLC) patients for anti-programmed cell death-1 (PD-1) or programmed death ligand 1 (PD-L1) therapy. In this study, we investigate for the first time to the best of our knowledge the prognostic and predictive utility of the LIPI in a multicenter nivolumab monotherapy-based cohort. We retrospectively analyzed the influence of the baseline LIPI on overall ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2019 - AME Publishing Company | Translational Lung Cancer Research
Rubén Maneiro, Antonio Ardá, Antonio Rial Boubeta, José Luís Losada, Claudio A. Casal, Sergio López-García,
Alcanzar un conocimiento más profundo (y con el soporte empírico adecuado) de los saques de esquina en el fútbol de máximo nivel. Se pretende conocer la incidencia real de este tipo de acciones durante los partidos, así como describir cuáles son las prácticas habituales. A continuación, se pretende identificar aquellas variables que puedan estar asociadas a la eficacia de estas acciones. Se plantean dos tipos de aproximaciones complementarias en el análisis de los datos: una de carácter univariada, ...
Tópico(s): Physical Education and Pedagogy
2016 - | Revista Andaluza de Medicina del Deporte
J. Casal Rubio, Sergio Vázquez‐Estévez, Francisca Vázquez, Margarita Amenedo, J. L. Fírvida, J. R. Mel, G. Huidobro, Elena Álvarez, M. Lázaro, G. Alonso, Irene Mirón Fernández,
Tópico(s): Lung Cancer Research Studies
2009 - Springer Science+Business Media | Cancer Chemotherapy and Pharmacology
Rubén Fernández‐Casal, Sergio Castillo-Páez, Mario Francisco‐Fernández,
In this work, a fully nonparametric geostatistical approach to estimate threshold exceeding probabilities is proposed. To estimate the large-scale variability (spatial trend) of the process, the nonparametric local linear regression estimator, with the bandwidth selected by a method that takes the spatial dependence into account, is used. A bias-corrected nonparametric estimator of the variogram, obtained from the nonparametric residuals, is proposed to estimate the small-scale variability. Finally, ...
Tópico(s): Statistical Methods and Inference
2017 - Springer Science+Business Media | Stochastic Environmental Research and Risk Assessment
Produção Nacional
Revisado por pares
Carina S. Casal, Graciela Arbilla, Sérgio Machado Corrêa,
Polycyclic aromatic hydrocarbons (PAHs) are widely studied in environmental matrices, such as air, water, soil and sediment, because of their toxicity, mutagenicity and carcinogenicity. Because of these properties, the environmental agencies of developed countries have listed sixteen PAHs as priority pollutants. Few countries have limits for these compounds for ambient air, but they only limit emissions from stationary and mobile sources and occupational areas. There are several studies to specifically ...
Tópico(s): Air Quality and Health Impacts
2014 - Elsevier BV | Atmospheric Environment
Rubén Fernández‐Casal, Sergio Castillo-Páez, Pilar García Soidán,
The current study aims to provide nonparametric estimators of the conditional variance and the dependence structure of a heteroscedastic spatial process. When assuming zero mean along the domain, the approximation of the variance can be addressed by linear smoothing of the squared observations. Then, the variogram can be estimated from the standardized data. In the presence of a non-zero deterministic trend, we suggest a modification of the latter method that involves the residuals obtained from ...
Tópico(s): Agricultural Economics and Policy
2017 - Elsevier BV | Spatial Statistics
Sonia B Casal, Horacio S. Wio, Sergio E. Mangioni,
We analyze here a model for an adsorbate system composed of many layers by extending a theoretical approach used to describe pattern formation on a monolayer of adsorbates with lateral interactions. The approach shows, in addition to a first order phase transition in the first layer, a transition in the second layer together with evidence of a "cascade" of transitions if more layers are included. The transition profiles, showing a staircase structure, corroborate this picture. The adsorption isotherm ...
Tópico(s): Material Dynamics and Properties
2002 - Elsevier BV | Physica A Statistical Mechanics and its Applications
S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, J. Hammer, S. Hänsel, M. Hoch, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, M. Krammer, D. Liko, I. Mikulec, M. Pernicka, B. Rahbaran, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, F. Teischinger, P. Wagner, W. Waltenberger, G. Walzel, E. Widl, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Bansal, L. Benucci, E. Wolf, X. Janssen, J. Maes, T. Maes, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, M. Selvaggi, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, F. Blekman, S. Blyweert, J. D’Hondt, O. Devroede, R. Gonzalez Suarez, A. Kalogeropoulos, M. Maes, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, O. Charaf, B. Clerbaux, G. De Lentdecker, V. Dero, A. P. R. Gay, G. H. Hammad, T. Hreus, P. E. Marage, L. Thomas, C. Vander Velde, P. Vanlaer, V. Adler, A. Cimmino, S. Costantini, M. Grünewald, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, D. Ryckbosch, F. Thyssen, M. Tytgat, L. Vanelderen, P. Verwilligen, S. Walsh, N. Zaganidis, S. Basegmez, G. Bruno, J. Caudron, L. Ceard, E. Cortina, J. De Favereau De Jeneret, C. Delaere, D. Favart, A. Giammanco, G. Grégoire, J. Hollar, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, S. Ovyn, D. Pagano, A. Pin, K. Piotrzkowski, N. Schul, N. Beliy, T. Caebergs, E. Daubie, G. A. Alves, L. Brito, J. Marco, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, E. M. Da Costa, C. De Oliveira Martins, S. Fonseca De Souza, L. Mundim, H. Nogima, V. Oguri, W. L. Prado Da Silva, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Laganá, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, N. Darmenov, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, S. Stoykova, G. Sultanov, V. Tcholakov, R. Trayanov, A. Dimitrov, R. Hadjiiska, A. Karadzhinova, V. Kozhuharov, L. Litov, M. Mateev, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Li, X. T. Meng, J. Tao, J. Wang, J. Wang, X. Wang, Z. Wang, H. Xiao, M. Xu, J. Zang, Z. Zhang, Y. Ban, S. Guo, Y. P. Guo, W. Li, Y. Mao, S. J. Qian, H. Teng, B. Zhu, W. Zou, A. Cabrera, B. Gomez Moreno, A. A. Ocampo Rios, A. F. Osorio Oliveros, J. C. Sanabria, N. Godinović, D. Lelas, K. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Dželalija, V. Brigljević, S. Duric, K. Kadija, S. Morovic, A. Attikis, M. Galanti, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, М. Фингер, М. Фингер, Y. Assran, A. Ellithi Kamel, S. Khalil, M. A. Mahmoud, A. Hektor, M. Kadastik, M. Müntel, M. Raidal, L. Rebane, A. Tiko, V. Azzolini, P. Eerola, G. Fedi, S. Czellar, J. Härkönen, A. Heikkinen, V. Karimäki, R. Kinnunen, M. J. Kortelainen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, E. Tuominen, J. Tuominiemi, E. Tuovinen, D. Ungaro, L. Wendland, K. Banzuzi, A. Karjalainen, A. Korpela, T. Tuuva, D. Sillou, M. Besançon, Sayantan Choudhury, M. Dejardin, D. Denegri, B. Fabbro, J. L. Faure, F. Ferri, S. Ganjour, F.X. Gentit, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, E. Locci, J. Malclès, M. Marionneau, L. Millischer, J. Rander, A. Rosowsky, I. Shreyber, M. Titov, P. Verrecchia, S. Baffioni, F. Beaudette, L. Benhabib, Lorenzo Bianchini, M. Bluj, C. Broutin, P. Busson, C. Charlot, T. Dahms, L. Dobrzyński, S. Elgammal, R. Granier de Cassagnac, M. Haguenauer, P. Miné, C. Mironov, C. Ochando, P. Paganini, D. Sabes, R. Salerno, Y. Sirois, Ch. Thiebaux, B. Wyslouch, A. Zabi, J.-L. Agram, J. Andreä, D. Blöch, D. Bodin, J.-M. Brom, M. Cardaci, E. C. Chabert, C. Collard, E. Conte, F. Drouhin, C. Ferro, J.-C. Fontaine,
Results are reported from a search for physics beyond the standard model in proton-proton collisions at a center-of-mass energy of 7 TeV, focusing on the signature with a single, isolated, high-transverse-momentum lepton (electron or muon), energetic jets, and large missing transverse momentum. The data sample comprises an integrated luminosity of 36 pb−1, recorded by the CMS experiment at the LHC. The search is motivated by models of new physics, including supersymmetry. The observed event yields ...
Springer Nature
Sergio Gonzalez Casal, Xiaofei Bai, Kévin Alhada−Lahbabi, B. Canut, Bertrand Vilquin, Pédro Rojo Romeo, Solène Brottet, David Abertini, Damien Deleruyelle, Matthieu Bugnet, I. C. Infante, Brice Gautier,
Abstract The mechanical switching of ferroelectric domains is achieved in PbZr 0.2 Ti 0.8 O 3 thin films obtained by the sol‐gel method for thicknesses up to 200 nm. The dielectric polarization can be switched when a force higher than a given threshold value in the order of some μNewtons is applied with the tip of an atomic force microscope. This threshold is determined as a function of the thickness of the films, and local hysteresis loops are recorded under mechanical stress. The possibility of ...
Tópico(s): Acoustic Wave Resonator Technologies
2022 - Wiley | Advanced Electronic Materials
David Bernardo, Alicia C Marín, Samuel Fernández‐Tomé, Ana Montalban‐Arques, Anna Carrasco, Eva Tristán, Lorena Ortega Moreno, Irene Mora‐Gutiérrez, A. Díaz-Guerra, R. Caminero-Fernández, Pedro Miguel Gomes da Silva Miranda, Fernando Casals, María Caldas, M. Carolina Jimenez, Sergio Casabona, Felipe de la Morena, María Esteve, Cecílio Santander, María Chaparro, Javier P. Gisbert,
Although macrophages (Mϕ) maintain intestinal immune homoeostasis, there is not much available information about their subset composition, phenotype and function in the human setting. Human intestinal Mϕ (CD45+HLA-DR+CD14+CD64+) can be divided into subsets based on the expression of CD11c, CCR2 and CX3CR1. Monocyte-like cells can be identified as CD11chighCCR2+CX3CR1+ cells, a phenotype also shared by circulating CD14+ monocytes. On the contrary, their Mϕ-like tissue-resident counterparts display ...
Tópico(s): Immune Response and Inflammation
2018 - Elsevier BV | Mucosal Immunology
Sergio Gonzalez Casal, Ignasi Fina, F. Sánchez, J. Fontcuberta,
Achieving large magnetoelectric coupling is of interest for memory and communication applications. In multiferroic hybrid structures (combining ferroelectric and magnetic materials) in the presence of a magnetoelectric coupling, the ferroelectric properties can be modulated by a magnetic field. This is called the direct magnetoelectric effect. Measuring the ferroelectric properties in multiferroic materials most commonly requires using metallic electrodes that sandwich the ferroelectric material. ...
Tópico(s): Underwater Acoustics Research
2019 - American Chemical Society | ACS Applied Electronic Materials
Rubén Maneiro, Claudio A. Casal, I Burón Álvarez, José Enrique Moral, Sergio López-García, Antonio Ardá, José Luís Losada,
Coaches, footballers and researchers agree that offensive transitions are one of the most important moments in football today. In a sport where defense over attack dominates, with low scores on the scoreboard, the importance of these actions from the offensive point of view becomes very important. Despite this, scientific literature is still very limited on this topic. Therefore, the objectives set out in the present investigation have been two: first, by means of a proportion analysis and the application ...
Tópico(s): Sport Psychology and Performance
2019 - Frontiers Media | Frontiers in Psychology
José Casal, Sergio Vázquez‐Estévez, Luís León, M. Lázaro, J. L. Fírvida, Margarita Amenedo, Guzmán Alonso, Lucía Santomé, Francisco Javier Afonso Afonso,
7537 Background: Combination of platinum-based chemotherapy and radiotherapy is the standard treatment for p with unresectable stage III NSCLC, but considering the high rates of recurrence, it is necessary to improve these results. Erlotinib is an EGFR TKI that prolongs survival in p with recurrent and metastatic NSCLC. In this study, we aim to evaluate the role of erlotinib as maintenance therapy after a standard concurrent chemo-radiotherapy regimen in p with stage III NSCLC. Methods: P with unresectable ...
Tópico(s): Lung Cancer Research Studies
2009 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
José Manuel ́Ramírez Rodríguez, Juan Antonio Blasco‐Amaro, José V. Roig, Sergio Maeso, José E Casal, Fernando Esteban, Daniel Callejo Lic,
Abstract Background Major colorectal surgery usually requires a hospital stay of more than 12 days. Inadequate pain management, intestinal dysfunction and immobilisation are the main factors associated with delay in recovery. The present work assesses the short and medium term results achieved by an enhanced recovery program based on previously published protocols. Methods This prospective study, performed at 12 Spanish hospitals in 2008 and 2009, involved 300 patients. All patients underwent elective ...
Tópico(s): Nausea and vomiting management
2011 - BioMed Central | BMC Surgery
Sergio Vázquez‐Estévez, J. Casal, Francisco Javier Afonso Afonso, J. L. Fírvida, Lucía Santomé, Francisco Javier Barón-López, Martín Lázaro, Carolina Pena, Margarita Amenedo, Ihab Abdulkader, Carmen González-Arenas, Laura Fachal, A. Vega,
This study aimed to assess the incidence of mutations in the epidermal growth factor receptor (EGFR) gene in non-small-cell lung cancer (NSCLC) patients in the Galician region of Spain and the clinical management and outcome of patients carrying EGFR mutations.All newly diagnosed advanced or metastatic NSCLC patients were screened for EGFR mutations in matched tumor samples (tissue or cytology specimens) and serum samples.Of 198 patients screened for EGFR mutations in tumor samples, 184 had evaluable ...
Tópico(s): Cancer Genomics and Diagnostics
2016 - Dove Medical Press | Cancer Management and Research
Mariana Ferrer‐Casal, Catherine Li, Melina Galizzi, Carlos A. Stortz, Sergio H. Szajnman, Roberto Docampo, Silvia N.J. Moreno, Juan B. Rodríguez,
As part of our project pointed at the search of new antiparasitic agents against American trypanosomiasis (Chagas disease) and toxoplasmosis a series of 2-alkylaminoethyl-1-hydroxy-1,1-bisphosphonic acids has been designed, synthesized and biologically evaluated against the etiologic agents of these parasitic diseases, Trypanosoma cruzi and Toxoplasma gondii, respectively, and also towards their target enzymes, T. cruzi and T. gondii farnesyl pyrophosphate synthase (FPPS), respectively. Surprisingly, ...
Tópico(s): Phosphorus compounds and reactions
2013 - Elsevier BV | Bioorganic & Medicinal Chemistry
Ariadna García-Saenz, Sebastián Napp, Sergio Luis González López, Jordi Casal, Alberto Allepuz,
The achievement of the Officially Tuberculosis Free (OTF) status in regions with low bovine Tuberculosis (bTB) herd prevalence, as is the case of North-Eastern Spain (Catalonia), might be a likely option in the medium term. In this context, risk-based approaches could be an alternative surveillance strategy to the costly current strategy. However, before any change in the system may be contemplated, a reliable estimate of the sensitivity of the different surveillance components is needed. In this study, ...
Tópico(s): Microbial infections and disease research
2015 - Elsevier BV | Preventive Veterinary Medicine
Tamila Galaka, Mariana Ferrer‐Casal, Melissa Storey, Catherine Li, María N. Chao, Sergio H. Szajnman, Roberto Docampo, Silvia N.J. Moreno, Juan B. Rodríguez,
Based on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates-Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1,1-bisphosphonic acids and other closely related derivatives were designed, synthesized and biologically evaluated against T. cruzi, the responsible agent of Chagas disease and against Toxoplasma gondii, the etiologic agent of toxoplasmosis and also towards the target enzymes farnesyl pyrophosphate synthase of T. cruzi (TcFPPS) and T gondii (TgFPPS), ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2017 - Multidisciplinary Digital Publishing Institute | Molecules
Montserrat Baldán‐Martín, Cristina Rubín de Célix, Macarena Orejudo, Lorena Ortega Moreno, Samuel Fernández‐Tomé, Irene Soleto, Cristina Ramírez, Ricardo Arroyo, Paloma Fernández, Cecílio Santander, J.A. Moreno-Monteagudo, María José Casanova, Fernando Casals, Sergio Casabona, Irene Becerro, Juan José Lozano, Ana M. Aransay, María Chaparro, Javier P. Gisbert,
Biological therapies only benefit one-third of patients with Crohn's disease (CD). For this reason, a deeper understanding of the mechanisms by which biologics elicit their effect on intestinal mucosa is needed. Increasing evidence points toward the involvement of long noncoding RNAs (lncRNAs) in the pathogenesis of CD, although their role remains poorly studied. We aimed to characterize lncRNA profiles in the ileum and colon from CD patients and evaluate the effect of anti-TNF-α treatment on their ...
Tópico(s): Cancer-related molecular mechanisms research
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
M. Leonor Teles-Grilo, Joana Tato-Costa, Sergio Duarte, Alexandre Maia, Graça Casal, Carlos Azevedo,
Perkinsus atlanticus is a pathogenic protist that infects the clam Ruditapes decussatus. The recent proposal for the inclusion of the genus Perkinsus in a new phylum, Perkinsozoa, in the infra-kingdom Alveolata, gave rise to controversies whether this genus should form a phylum on its own. Molecular analysis of some conserved nuclear genes shows a closer proximity of the genus Perkinsus to the dinoflagellates than to the apicomplexans. Studies on extranuclear genomes, however, could also be very ...
Tópico(s): Genomics and Phylogenetic Studies
2007 - Elsevier BV | European Journal of Protistology
Javier Bezos, Sérgio Corrêa Marques, Julio Álvarez, Carmen Casal, Beatriz Romero, Ana Grau, Olga Mínguez, Lucas Domı́nguez, Lucía de Juan,
Goats can act as reservoirs for tuberculosis (TB) infection. The main etiological agents of TB in goats are Mycobacterium caprae and Mycobacterium bovis and they infect also a wide range of domestic and wild animals and humans. Control programmes based mainly on the application of single and comparative intradermal tuberculin (SIT and SCIT respectively) tests are being implemented in certain regions of Spain with a high density of caprine flocks as Castilla y León, including goats with epidemiological ...
Tópico(s): Infectious Diseases and Tuberculosis
2013 - Elsevier BV | Research in Veterinary Science
Cristina Casals Miralles, Debora Barioni, Maria Serena Mancini, Joan Colón Jordà, Mercè Boy-Roura, Sergio Ponsá, Laia Llenas Argelaguet, Alessandro Galli,
Tourism places pressures on the environment through the services provided (accommodation, food, leisure activities, and transport), meanwhile it is particularly vulnerable to global warming as climate is a crucial component of destinations' attractiveness. As a result, research focusing on the impacts of tourism has increased significantly. Practitioners consult a plethora of frameworks and publications to environmentally assess tourism but none of the existing guidelines provides specific recommendations ...
Tópico(s): Urban Transport and Accessibility
2023 - Elsevier BV | Journal of Cleaner Production
Jorge L. Martı́nez-Torrecuadrada, Lawrence H. Cheung, Paula López-Serra, Rodrigo Barderas, Marta Cañamero, Sergio Ferreiro, Michael G. Rosenblum, J. Ignacio Casal,
Abstract Human single-chain Fv directed against fibroblast growth factor receptor 3 (FGFR3) have been shown to block proliferation of RT112 bladder carcinoma cells in vitro. Here, we examined the ability of the recombinant gelonin toxin (rGel) to enhance this inhibitory effect in vitro and in vivo on the bladder cancer cell line RT112 and the corresponding xenografts. Immunotoxins were genetically engineered by fusing FGFR3-specific Fv fragments (3C) to the NH2 terminus of rGel and expressed as a soluble ...
Tópico(s): Microbial metabolism and enzyme function
2008 - American Association for Cancer Research | Molecular Cancer Therapeutics
Llorenç Grau‐Roma, Charlotte Kristiane Hjulsager, Marina Sibila, Charlotte Sonne Kristensen, Sergio Luis González López, Claes Enøe, Jordi Casal, Anette Bøtner, Miquel Nofrarías, Vivi Bille‐Hansen, Lorenzo Fraile, Poul Bækbo, Joaquím Segalés, Lars Erik Larsen,
Longitudinal case–control studies were performed in post-weaning multisystemic wasting syndrome (PMWS) affected farms from Denmark and Spain using similar designs. Fourteen independent batches of 100–154 pigs per batch were monitored from birth to PMWS outbreak occurrence. Pigs displaying PMWS-like signs and matched healthy cohorts were euthanized during the clinical outbreak. PMWS was diagnosed according to internationally accepted criteria and pigs were classified as: (i) PMWS cases, (ii) wasted ...
Tópico(s): Viral Infections and Immunology Research
2008 - Elsevier BV | Veterinary Microbiology
Sergio H. Szajnman, Juan B. Rodríguez, Mariana Ferrer‐Casal, Alejandro P. Barboza,
The use of tetraethyl vinylidenebisphosphonate as a dipolarophile in 1,3-dipolar cycloaddition reactions was investigated. In particular, the cycloaddition reactions between tetraethyl vinylidenebisphosphonate and azides and nitrile oxides, and of tetraethyl vinylidenebisphosphonate in the Grigg azomethine 1,3-dipolar cyclization were studied, affording highly functionalized five-membered rings containing the bisphosphonic unit. These straightforward methods allow the preparation of diverse and ...
Tópico(s): Chemical Synthesis and Analysis
2013 - Thieme Medical Publishers (Germany) | Synthesis
Marcello Gelormini, Albertino Damasceno, Simão António Lopes, Sérgio Maló, Célia Chongole, Paulino Muholove, Susana Casal, Olı́via Pinho, Pedro Moreira, Patrícia Padrão, Nuno Lunet,
Street food represents a cultural, social, and economic phenomenon that is typical of urbanized areas, directly linked with a more sedentary lifestyle and providing a very accessible and inexpensive source of nutrition. Food advertising may contribute to shaping consumers' preferences and has the potential to drive the supply of specific foods.The purpose of this study is to characterize the street food offerings available to the urban population of Maputo, the capital city of Mozambique, and the ...
Tópico(s): Food Safety and Hygiene
2015 - JMIR Publications | JMIR Research Protocols
Sofia Sousa, Marcello Gelormini, Albertino Damasceno, Simão António Lopes, Sérgio Maló, Célia Chongole, Paulino Muholove, Susana Casal, Olı́via Pinho, Pedro Moreira, Nuno Lunet, Patrícia Padrão,
A nutrition transition is occurring in the urban areas of developing countries, where street food makes an important contribution to daily food intake.We aimed to characterise street food offer in Maputo, Mozambique, and to evaluate the nutritional composition of the most common homemade foods.A cross-sectional study was conducted in 2014. Streets in the surroundings (500 m buffer) of randomly selected public transport stops in KaMpfumu district, Maputo, were canvassed to identify all street food ...
Tópico(s): Child Nutrition and Water Access
2018 - SAGE Publishing | Nutrition and Health