Ana Gadea, Sergio Schinelli, Vittorio Gallo,
Reactive gliosis is characterized by enhanced glial fibrillary acidic protein (GFAP) expression, cellular hypertrophy, and astrocyte proliferation. The cellular and molecular mechanisms underlying this process are still largely undefined. We investigated the role of endothelin-1 (ET-1) in reactive gliosis in corpus callosum after lysolecithin (LPC)-induced focal demyelination and in cultured astrocytes. We show that ET-1 levels are upregulated in demyelinated lesions within 5 d after LPC injection, ...
Tópico(s): Neuroscience and Neuropharmacology Research
2008 - Society for Neuroscience | Journal of Neuroscience
M. Sánchez, Pilar Alamá, B. Gadea, Sérgio Reis Soares, Carlos Simón, António Pellicer,
BACKGROUND: Ovarian orthotopic transplantation in patients with premature ovarian failure is reported to result in full-term pregnancies. Ischaemia and freezing/thawing are potentially injurious for tissues. This study was designed to analyse the effect of ischaemia on long-term ovarian function in humans. METHODS: Prospective case–control study. Subjects were 12 premenopausal women undergoing hysterectomy and fresh orthotopic transplantation of the entire ovarian cortex plus a control group of ...
Tópico(s): Reproductive System and Pregnancy
2006 - Oxford University Press | Human Reproduction
Joan Martí‐Fàbregas, Daniel Guisado‐Alonso, Raquel Delgado‐Mederos, Alejandro Martínez‐Domeño, Luís Prats‐Sánchez, Marina Guasch‐Jiménez, Pere Cardona, Ana Núñez-Guillén, Manuel Requena, Marta Rubiera, Marta Olivé‐Gadea, Alejandro Bustamante, Meritxell Gomis, Sergio Amaro, Laura Llull, Xavier Ustrell, Gislaine Castilho de Oliveira, Laia Seró, Manuel Gómez‐Choco, Luis J. Mena, Joaquı́n Serena, Saima Bashir, Francisco Purroy, Mikel Vicente‐Pascual, Ana Rodríguez-Campello, Ángel Ois, Esther Catena, M.C. García-Carreira, Oriol Barrachina, Ernest Palomeras, Jerzy Krupiński, Marta Almería, Josep Zaragoza, Patricia Esteve, Dolores Cocho, Antía Moreira, Cecile van Eendenburg, Javier Codas, Natàlia Pérez de la Ossa, Mercé Salvat, Pol Camps‐Renom,
We evaluated whether stroke severity, functional outcome, and mortality are different in patients with ischemic stroke with or without coronavirus disease 2019 (COVID-19) infection.A prospective, observational, multicentre cohort study in Catalonia, Spain. Recruitment was consecutive from mid-March to mid-May 2020. Patients had an acute ischemic stroke within 48 hours and a previous modified Rankin Scale (mRS) score of 0 to 3. We collected demographic data, vascular risk factors, prior mRS score, ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - Lippincott Williams & Wilkins | Stroke
M. Sánchez, Pilar Alamá, B. Gadea, Sérgio Reis Soares, Carlos Simón, António Pellicer,
An increasing number of young women are being diagnosed with cancer, and most cancer treatments have irreversibly negative effects on reproduction. Ovarian stimulation and preservation of oocytes or embryos is far from an ideal solution, in part because hormonal treatment may adversely affect some cancers. Another possibility is cryopreservation of ovarian tissue for later autotransplantation, but the ischemic damage caused by the procedure can lead to follicle loss. Using the ovarian medulla for ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2007 - Lippincott Williams & Wilkins | Obstetrical & Gynecological Survey
Mònica Millán, Anna Ramos‐Pachón, Laura Dorado, Alejandro Bustamante, María Hernández‐Pérez, Luis Rodríguez‐Esparragoza, Meritxell Gomis, Sebastián Remollo, Carlos Castaño, Mariano Werner, Denisse Wenger, Sara Rubio‐Guerra, Manuel Domínguez-Lizarbe, Mikel Terceño, Andrés Paipa, Alejandro Rodríguez-Vázquez, Sandra Boned, Pol Camps‐Renom, David Cánovas, Eva Giralt, Elena López‐Cancio, Antoni Dávalos, Josep Ros-Roig, Natàlia Pérez de la Ossa, Pere Cardona, Helena Quesada, Blanca Lara, Ana Nuñez Guillen, Roger Barranco, Lucía Aja, Paloma Mora, Óscar Chirife, Sònia Aixut, María Ángeles de Miquel, Antonio Martı́nez-Yélamos, Carlos A. Molina, Marta Rubiera, Jorge Pagola, David Rodríguez‐Luna, Marián Muchada, Alejandro Tomasello, Marc Ribó, Carlos Piñana, Manuel Requena, Matías Deck, Álvaro García‐Tornel, Marta Olivé‐Gadea, Noelia Rodríguez, Jesus Jueg, Ángel Chamorro, Sergio Amaro, Xabier Urra, Laura Llull, Arturo Renú, Salvatore Rudiloso, Juan Macho, Jordi Blasco, Luís San Román, Antonio López‐Rueda, Federico Zarco, Ramón Torné, R. Valero, Vı́ctor Obach, Víctor Vera, Martha Vargas, Carlos Laredo, Joan Martí‐Fàbregas, Raquel Delgado‐Mederos, Alejandro Martínez‐Domeño, Luís Prats‐Sánchez, Daniel Guisado‐Alonso, Marina Guasch‐Jiménez, Rebeca Marín Bueno, Jordi Branera-Pujol, José Pablo Martínez, Lavinia Dinia, Anna Pellisé, Xavier Ustrell, Alan Flores, Laia Seró, Joaquı́n Serena, Yolanda Silva, Saima Bashir, Víctor Vera, Alan Murillo, Jerzy Krupiński, Sonia Huertas, Jessica Molina, Georgina Figueras, Sarah Besora, Ana Rodríguez-Campello, Jaume Roquer, Ángel Ois, Elisa Cuadrado‐Godia, Jordi Jiménez‐Conde, Elío Vivas, Polo Guimaraens, Carmen García‐Rodríguez, Jordi Estela, J. Perendreu, Nicolás Romero, Roberto Eduardo Correa, Oriol Barrachina, Moisès Broggi, Manuel Gómez‐Choco, Sònia García, Maria Àngels Font Padrós, Juan José Mengual Chirife, Luis Mena Romo, Ernest Palomeras, V. Casado, Nicolau Guanyabens, Marta Álvarez, Esther Catena, José Luis Camacho Velasquez, Francisco Purroy, Gerard Mauri, Cristina García, Jessica García Alhama, Irene Bragado Trigo, Jordi Monedero, Mònica Perecaula, Luis Guillermo Casanovas, Carla Colom, Dolores Cocho, Adela Rios González, Juanjo Baiges, Josep Zaragoza, Gisela Martin, Sonia Escalante, Patricia Esteve, Iago Payo, Lidia Binela, Josep Maria Aragonés, Núria Matos, Josep Maria Soler-Insa, Natalia Más, Glòria Díaz, Margarida Vergés, Xavier Costa, Liseth Molina, M. Cruz Almendros, Marc Pérez, Ana Cabanelas, Olga Belchí, Maria Rybyeba, Miquel Barceló, Dolors Carrión, Carmen Repullo, Eduard Sanjurjo, Mercè Salvat Plana, Josep Roig, Verònica Hidalgo, Olga Fagúndez, Victòria Sala, Anabel Bocanegra Alonso, Marisol Querol, Montse Gorchs, Xavier Jiménez, Maria Àngels Mora,
Mechanical thrombectomy (MT) in ischemic stroke patients with poor prestroke conditions remains controversial. We aimed to analyze the frequency of previously disabled patients treated with MT in clinical practice, the safety and clinical response to MT of patients with preexisting disability, and the disabled patient characteristics associated with a better response to MT.We studied all consecutive patients with anterior circulation occlusion treated with MT from January 2017 to December 2019 included ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2021 - Lippincott Williams & Wilkins | Stroke
Agustín Ibáñez, Marcelo Cetkovich, Agustín Petroni, Hugo Urquina, Sandra Báez, María Luz González-Gadea, Juan E. Kamienkowski, Teresa Torralva, Fernando Torrente, Sergio Strejilevich, Julia Teitelbaum, Esteban Hurtado, Raphaël Guex, Margherita Melloni, Alicia Lischinsky, Mariano Sigman, Facundo Manes,
Background Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD. Methodology/Principal Findings We used the Iowa gambling task (IGT), a task of rational decision-making under risk (RDMUR) and a rapid-decision gambling task (RDGT) ...
Tópico(s): Neural and Behavioral Psychology Studies
2012 - Public Library of Science | PLoS ONE
Sandra Báez, Eduar Herrera, Lilian Villarin, Donna Theil, María Luz González-Gadea, Pedro Araos Gómez, Marcela Mosquera, David Huepe, Sergio Strejilevich, Nora Silvana Vigliecca, Franziska Matthäus, Jean Decety, Facundo Manes, Agustín Ibáñez,
Background The ability to integrate contextual information with social cues to generate social meaning is a key aspect of social cognition. It is widely accepted that patients with schizophrenia and bipolar disorders have deficits in social cognition; however, previous studies on these disorders did not use tasks that replicate everyday situations. Methodology/Principal Findings This study evaluates the performance of patients with schizophrenia and bipolar disorders on social cognition tasks (emotional ...
Tópico(s): Obsessive-Compulsive Spectrum Disorders
2013 - Public Library of Science | PLoS ONE
Gibraltar Conde Aideé, Adolfina Berges García, Sheila Parra Gómez, Miguel Angel Gutierrez Agama,
... Berges GarcíaSearch for more papers by this authorSergio Gadea Gómez, Sergio Gadea GómezSearch for more papers by this authorMiguel ... Berges GarcíaSearch for more papers by this authorSergio Gadea Gómez, Sergio Gadea GómezSearch for more papers by this authorMiguel Angel ...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2014 - Wiley | PM&R
J. Gadea, Adolfo Toledano‐Díaz, Sergio Navarro-Serna, María Jiménez‐Movilla, Pilar Soriano, C. Matás, J. Santiago‐Moreno,
The Black Crested Mangabey (Lophocebus aterrimus) is an African monkey listed as Near Threatened by the IUCN and in captivity the population is limited to 34 males. The aim of this study was to evaluate two Black Crested Mangabey males, maintained in captivity in a zoological garden and suspected of infertility, with a complete examination of their genital tract using ultrasonography, followed by recovery of semen using transrectal ultrasonic massage of the accessory sexual glands (TUMASG) and electroejaculation. ...
Tópico(s): Reproductive Biology and Fertility
2019 - Elsevier BV | Animal Reproduction Science
Mudassir Farooqui, Osama O. Zaidat, Ameer E Hassan, Darko Quispe‐Orozco, Nils Petersen, Afshin A. Divani, Marc Ribó, Michael Abraham, Johanna T Fifi, Waldo R. Guerrero, Amer Malik, James E. Siegler, Thanh N. Nguyen, Sunil A. Sheth, Albert J. Yoo, Guillermo Linares, Nazli Janjua, Milagros Galecio‐Castillo, Wondewossen Tekle, Victor M Ringheanu, Marion Oliver, Giana Dawod, Jessica Kobsa, Ayush Prasad, Asad Ikram, Eugene Lin, Kristine Below, Cynthia Zevallos, Marta Olivé‐Gadea, Abid Qureshi, Andres Dajles, Stavros Matsoukas, Ameena Rana, Mohamad Abdalkader, Sergio Salazar‐Marioni, Jazba Soomro, Weston Gordon, Juan Vivanco‐Suarez, Charoskhon Turabova, Maxim Mokin, Dileep R. Yavagal, Mouhammad Jumaa, Santiago Ortega‐Gutiérrez,
Approximately 10% to 20% of large vessel occlusion (LVO) strokes involve tandem lesions (TLs), defined as concomitant intracranial LVO and stenosis or occlusion of the cervical internal carotid artery. Mechanical thrombectomy (MT) may benefit patients with TLs; however, optimal management and procedural strategy of the cervical lesion remain unclear.
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2023 - American Medical Association | JAMA Network Open
Fatih Şeker, Muhammad M. Qureshi, Markus Möhlenbruch, Raul G. Nogueira, Mohamad Abdalkader, Marc Ribó, François Caparros, Diogo C Haussen, Mahmoud Mohammaden, Sunil A. Sheth, Santiago Ortega‐Gutiérrez, James E. Siegler, Syed Zaidi, Marta Olivé‐Gadea, Hilde Hénon, Alicia C. Castonguay, Stefania Nannoni, Johannes Kaesmacher, Ajit S Puri, Mudassir Farooqui, Sergio Salazar‐Marioni, Anna Luisa Kühn, Nicole L. Kiley, Behzad Farzin, William Boisseau, Hesham Masoud, Carlos Ynigo Lopez, Ameena Rana, Samer Abdul Kareem, Anvitha Sathya, Piers Klein, Mohammad W. Kassem, Charlotte Cordonnier, Jan Gralla, Urs Fischer, Patrik Michel, Davide Strambo, Tudor Jovin, Jean Raymond, Osama O. Zaidat, Peter A. Ringleb, Thanh N. Nguyen, Simon Nagel,
Reperfusion without functional independence (RFI) is an undesired outcome following thrombectomy in acute ischemic stroke. The primary objective was to evaluate, in patients presenting with proximal anterior circulation occlusion stroke in the extended time window, whether selection with computed tomography (CT) perfusion or magnetic resonance imaging is associated with RFI, mortality, or symptomatic intracranial hemorrhage (sICH) compared with noncontrast CT selected patients.The CLEAR study (CT for ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2022 - Lippincott Williams & Wilkins | Stroke
Isabel Faus, Ana Zabalza, Julia Santiago, Sergio G. Nebauer, Mercedes Royuela, Ramón Serrano, José Gadea,
The increased selection pressure of the herbicide glyphosate has played a role in the evolution of glyphosate-resistance in weedy species, an issue that is becoming a threat to global agriculture. The molecular components involved in the cellular toxicity response to this herbicide at the expression level are still unidentified.
Tópico(s): Plant tissue culture and regeneration
2015 - BioMed Central | BMC Plant Biology
Sergio Navarro-Serna, Marcela Vilariño, Insung Park, J. Gadea, Pablo J. Ross,
The breakthrough and rapid advance of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) technology has enabled the efficient generation of gene-edited animals by one-step embryo manipulation. Clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9 delivery to the livestock embryos has been typically achieved by intracytoplasmic microinjection; however, recent studies show that electroporation may be a reliable, efficient, ...
Tópico(s): Innovation and Socioeconomic Development
2020 - Elsevier BV | Journal of Equine Veterinary Science
Isabel Faus, Regina Niñoles, Vigya Kesari, Paula Llabata, Emily W. T. Tam, Sergio G. Nebauer, Julia Santiago, Marie‐Theres Hauser, José Gadea,
One of the main mechanisms blocking translation after stress situations is mediated by phosphorylation of the α-subunit of the eukaryotic initiation factor 2 (eIF2), performed in Arabidopsis by the protein kinase GCN2 which interacts and is activated by ILITHYIA(ILA). ILA is involved in plant immunity and its mutant lines present phenotypes not shared by the gcn2 mutants. The functional link between these two genes remains elusive in plants. In this study, we show that, although both ILA and GCN2 ...
Tópico(s): Plant-Microbe Interactions and Immunity
2018 - Elsevier BV | Journal of Plant Physiology
Thanh N. Nguyen, Mohamad Abdalkader, Simon Nagel, Muhammad M. Qureshi, Marc Ribó, François Caparros, Diogo C Haussen, Mahmoud Mohammaden, Sunil A. Sheth, Santiago Ortega‐Gutiérrez, James E. Siegler, Syed Zaidi, Marta Olivé‐Gadea, Hilde Hénon, Markus Möhlenbruch, Alicia C. Castonguay, Stefania Nannoni, Johannes Kaesmacher, Ajit S Puri, Fatih Şeker, Mudassir Farooqui, Sergio Salazar‐Marioni, Anna Luisa Kühn, Artem Kaliaev, Behzad Farzin, William Boisseau, Hesham Masoud, Carlos Ynigo Lopez, Ameena Rana, Samer Abdul Kareem, Anvitha Sathya, Piers Klein, Mohammad W. Kassem, Peter A. Ringleb, Charlotte Cordonnier, Jan Gralla, Urs Fischer, Patrik Michel, Tudor Jovin, Jean Raymond, Osama O. Zaidat, Raul G. Nogueira,
Advanced imaging for patient selection in mechanical thrombectomy is not widely available.To compare the clinical outcomes of patients selected for mechanical thrombectomy by noncontrast computed tomography (CT) vs those selected by computed tomography perfusion (CTP) or magnetic resonance imaging (MRI) in the extended time window.This multinational cohort study included consecutive patients with proximal anterior circulation occlusion stroke presenting within 6 to 24 hours of time last seen well from ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2021 - American Medical Association | JAMA Neurology
James E. Siegler, Muhammad M. Qureshi, Raul G. Nogueira, Kanta Tanaka, Simon Nagel, Patrik Michel, Nicholas Vigilante, Marc Ribó, Hiroshi Yamagami, Shinichi Yoshimura, Mohamad Abdalkader, Diogo C Haussen, Mahmoud Mohammaden, Stefania Nannoni, Markus Möhlenbruch, Hilde Hénon, Sunil A. Sheth, Santiago Ortega‐Gutiérrez, Marta Olivé‐Gadea, François Caparros, Fatih Şeker, Syed Hassan Ejaz Zaidi, Alicia C. Castonguay, Kazutaka Uchida, Nobuyuki Sakai, Ajit S Puri, Mudassir Farooqui, Ḱazunori Toyoda, Sergio Salazar‐Marioni, Masataka Takeuchi, Behzad Farzin, Hesham Masoud, Anna Luisa Kühn, Ameena Rana, Masafumi Morimoto, Masunari Shibata, Tadashi Nonaka, Piers Klein, Anvitha Sathya, Nicole L. Kiley, Charlotte Cordonnier, Davide Strambo, Jelle Demeestere, Peter A. Ringleb, Daniel Roy, Osama O. Zaidat, Tudor Jovin, Johannes Kaesmacher, Urs Fischer, Jean Raymond, Thanh N. Nguyen,
Background and Objectives Current guidelines do not address recommendations for mechanical thrombectomy (MT) in the extended time window (>6 hours after time last seen well [TLSW]) for large vessel occlusion (LVO) patients with preexisting modified Rankin Scale (mRS) > 1. In this study, we evaluated the outcomes of MT vs medical management in patients with prestroke disability presenting in the 6- to 24-hour time window with acute LVO. Methods We analyzed a multinational cohort (61 sites, 6 countries from 2014 to ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2022 - Lippincott Williams & Wilkins | Neurology
Milagros Galecio‐Castillo, Mudassir Farooqui, Ameer E Hassan, Mouhammad Jumaa, Afshin A. Divani, Marc Ribó, Michael Abraham, Nils Petersen, Johanna T. Fifi, Waldo R. Guerrero, Amer Malik, James E. Siegler, Thanh N. Nguyen, Sunil A. Sheth, Albert J. Yoo, Guillermo Linares, Nazli Janjua, Darko Quispe‐Orozco, Wondwossen Tekle, Syed Zaidi, Sara Y. Sabbagh, Marta Olivé‐Gadea, Tiffany Barkley, Reade De Leacy, Kenyon W. Sprankle, Mohamad Abdalkader, Sergio Salazar‐Marioni, Jazba Soomro, Weston Gordon, Charoskhon Turabova, Juan Vivanco‐Suarez, Aarón Rodríguez-Calienes, Maxim Mokin, Dileep R. Yavagal, Tudor Jovin, Santiago Ortega‐Gutiérrez,
Effect of endovascular therapy (EVT) in acute large vessel occlusion (LVO) patients with tandem lesions (TLs) within 6-24 hours after last known well (LKW) remains unclear. We evaluated the clinical and safety outcomes among TL-LVO patients treated within 6-24 hours.
Tópico(s): Venous Thromboembolism Diagnosis and Management
2023 - | Journal of Stroke
Celia Piñeiro-Silva, Sergio Navarro-Serna, Ramsés Belda-Pérez, J. Gadea,
The generation of genetically modified pigs has an important impact thanks its applications in basic research, biomedicine, and meat production. Cloning was the first technique used for this production, although easier and cheaper methods were developed, such as the microinjection, electroporation, or lipofection of oocytes and zygotes. In this study, we analyzed the production of genetically modified embryos via lipofection of zona-pellucida-intact oocytes using LipofectamineTM CRISPRMAXTM Cas9 ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2023 - Multidisciplinary Digital Publishing Institute | Animals
Roxana Andrea Roeschlin, María Alejandra Favaro, María Amalia Chiesa, Sergio Alemano, Adrián A. Vojnov, Atilio Pedro Castagnaro, María Paula Filippone, Frederick G. Gmitter, José Gadea, María Rosa Maraño,
Xanthomonas citri ssp. citri (X. citri) is the causal agent of Asiatic citrus canker, a disease that seriously affects most commercially important Citrus species worldwide. We have identified previously a natural variant, X. citri A
Tópico(s): Plant Parasitism and Resistance
2016 - Wiley | Molecular Plant Pathology
Juan Souteras, Andrés Flevaris, Germán Gadea, Sergio Nesmachnow, Alejandro Guitiérrez, Gabriel Cazes,
This paper presents an efficient parallel algorithm for the problem of converting satellite imagery in binary files. The algorithm was designed to update at global scale the land cover information used by the WRF climate model. We present the characteristics of the implemented algorithm, as well as the results of performance analysis and comparisons between two approaches to implement the algorithm. The performance analysis shows that the implemented parallel algorithm improves substantially against ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2012 - Latin American Center for Computer Studies | CLEI electronic journal
Héctor Gadea Uribarria, Carlos Lago‐Fuentes, Ainhoa Bores Arce, Sergio López-García, Enrique Ibáñez, Carlos Serrano, Elena Mainer-Pardos,
Purpose: The purpose of this study was to to evaluate the validity of a new tracking device that allows measuring different performance factors in futsal real game situations. Methods: 10 high elite futsal players performed a typical futsal training task, this is, a 4v4 in 28×20m with a duration of 180 seconds, where players wore two tracking devices, the new one (OLIVER) and the already validated device (WIMU PRO). Data recorded by the OLIVER and WIMU PRO systems were compared after the training ...
Tópico(s): Lower Extremity Biomechanics and Pathologies
2023 - | Acta kinesiologica
Tony Mok, Luis Paz‐Ares, Yi‐Long Wu, Silvia Novello, Erzsébet Juhász, Osvaldo Rudy Aren, Yue Sun, V. Hirsh, Ellen Smit, Chetan Lathia, Teng Jin Ong, Carol E. Peña, X. Pivot, Gilles Romieu, H. Bonnefoi, J-Y Pierga, P. Kerbrat, J P Guastalla, Alain Lortholary, M. Espié, P. Fumoleau, D. Serin, J.P. Jacquin, C. Jouannaud, M. Rios, Sophie Abadie‐Lacourtoisie, N. Tubiana-Mathieu, L. Cany, Stéphanie Catala, D. Khayat, Iris Pauporté, A. Kramar, A. Goldhirsch, M. Piccart, Marion Procter, E. De Azambuja, H. Wéber, M. Untch, I. E. Smith, L. Gianni, C. Jackisch, David Cameron, Richard H. Bell, Mitch Dowsett, Richard D. Gelber, B Leyland-Jones, José Baselga, Michael Baum, Jayant S. Vaidya, Max Bulsara, F. Wenz, Jeffrey Tobias, W. Eiermann, David Joseph, J. Y. Pierga, B Asselain, Samar Alsafadi, Étienne Brain, Florence Lerebours, S. Delaloge, David Gentien, Nicolas Servant, Brigitte Sigal‐Zafrani, François André, Carmen Criscitiello, H.A. Azim, D. Agbor-Tarh, Holger Eidtmann, S. Di Cosimo, I. Bradbury, IT Rubio, Semiglazov Vf, Bogdan Żurawski, R. Allerton, A. Fabi, E. Ciruelos, Roma Parikh, Michelle DeSilvio, Sergio Santillana, Ramona F. Swaby, Sunil Verma, David Miles, Ian E. Krop, Manfred Welslau, Mark D. Pegram, D. Oh, Véronique Dièras, Ellie Guardino, Lina Fang, Minjun Lu, S. Olsen, Kimberly Blackwell, Thomas Bachelot, Mario Campone, M Ballester, Frédéric Commo, Allan Christian Pieroni Gonçalves, Campbell L. Levy, Juan Pablo Ferrero, Ludovic Lacroix, F. Dalenc, Magali Lacroix, Qi Wang, José Adélaı̈de, M. Carolina Jimenez, C. Heery, NK Ibrahim, Ravi A. Madan, Mahsa Mohebtash, Philip M. Arlen, Sheri McMahon, S. Hodge, S. M. Steinberg, J Schlom, James L. Gulley, Bruno Chauffert, L. Feuvret, F. Bonnetain, L. Taillandier, D. Frappaz, J. Honnorat, M. Fabbro, Marc Frénay, Xavier Durando, Isabelle Tennevet, J.-S. Guillamo, H. Tailla, Roland Schött, F. Ghiringhelli, C. Campello, Cécile Dalban, J. Skrzypski, Olivier Chinot, Émeline Tabouret, Françoise Boudouresque, Maryline Barrié, María G. Matta, Céline Boucard, A. Loundou, M. Ouafik, Yue Xu, Mauro José Lahm Cardoso, Michael Palumbo, O. Ishibashi, H. Oltean, Krishna Kumari, Petr Kavan, A. James, P. Mulholland, S. Peoples, O. Al-Salihi, C. Twelves, S. Jefferies, S. Halford, Jordan Ritchie, H. Singh-Jasuja, R. Rampling, J. Taieb, J. Tabernero, Enrico Mini, Fabien Subtil, G. Folprecht, Jean–Luc Van Laethem, J. Thaler, J.A. Bridgewater, E.J.D. Van Cutsem, P. Rougier, Laurence Collette, M. Praet, M. Schneider, Olivier Bouché, C. Lepage, Cécile Girault, JF Émile, P. Laurent-Puig, L. Bedenne, Gianluca Masi, F. Loupakis, L. Salvatore, Chiara Cremolini, Lorenzo Fornaro, M. Schirripa, Elena Fea, Cristina Granetto, L. Antonuzzo, Elisa Giommoni, G. Allegrini, S. Cupini, Christian Boni, M. Banzi, S. Chiara, C. Sonaglio, C. Valsuani, A. Bonetti, Luca Boni, Alfredo Falcone, Axel Grothey, Alberto F. Sobrero, Salvatore Siena, Marc Ychou, Yves Humblet, Laurent Mineur, Carlo Barone, Antoine Adenis, Tetsuhiro Yoshino, H-J Lenz, Richard M. Goldberg, D.J. Sargent, Frank Cihon, Lisa Cupit, Alexandra Wagner, Dirk Laurent, Andrew X. Zhu, Olivier Rosmorduc, J Evans, R. Paul Ross, Antonino Santoro, Flair José Carrilho, M. Leberre, Maj‐Britt Jensen, Gudrun Meinhardt, Y. Kang, F. Lordick, G. Bodoky, Hyunsoo Chung, G. Kurteva, Sang Cheul Oh, Pamela Salman, Heiko Goette, Helena Melezínková, Markus Moehler, Kazuhiro Yoshida, Masashi Fujii, Wasaburo Koizumi, Hongbeom Kim, Yang‐Hyun Kim, M. Takeuchi, Takeshi Nakajima, D. Ferry, S.J. Dutton, Wasat Mansoor, John F. Thompson, M. Harrison, Haider Abbas, Åsa Dahle-Smith, Anindya Chatterjee, Stephen Falk, Angel Garcia-Alonso, D. Fyfe, R. Hubner, Tina Gamble, Lynnda Peachey, Mina Davoudianfar, Sarah Pearson, Patrick Julier, Janusz Jankowski, Rachel Midgely, Russell Petty, Robert J. Motzer, Thomas E. Hutson, James A. Reeves, Robert D. Hawkins, Jiafu Ji, Paul Nathan, Michael Staehler, Paul de Souza, Jaime R. Merchan, Kate Fife, Jie Jin, Robin L. Jones, Hirotsugu Uemura, U. De Giorgi, Ulrika Harmenberg, J. Wang, D. Cella, Lauren McCann, K.I. Deen, Toni K. Choueiri, Brian I. Rini, J. Bellmunt, Jill S. Clancy, Kai Wang, Andreas G. Niethammer, B. Escudier, Thomas E. Hutson, Emilio Esteban, Georg A. Bjarnason, Ho Young Lim, K. Pittman, P. Senico, Dongrui R. Lu, Santosh Hariharan, Robert J. Motzer, David Olmos, Daniel Brewer, Gerhardt Attard,
ABSTRACT Background Tumor EGFR and KRas mutations are both predictive and prognostic biomarkers in patients with advanced NSCLC. We analyzed the correlation between these biomarkers and treatment outcomes in a phase III trial of 3rd/4th line sorafenib in patients with NSCLC. Methods The global, randomized, placebo-controlled MISSION trial enrolled 703 patients with advanced relapsed/refractory NSCLC of predominantly non-squamous histology. The primary study endpoint was overall survival (OS). EGFR ...
Elsevier BV
Mudassir Farooqui, Milagros Galecio‐Castillo, Ameer E Hassan, Afshin A. Divani, Mouhammad Jumaa, Marc Ribó, Nils Petersen, Michael Abraham, Johanna T Fifi, Waldo R. Guerrero, Amer Malik, James E. Siegler, Thanh N. Nguyen, Sunil A. Sheth, Albert J. Yoo, Guillermo Linares, Nazli Janjua, Darko Quispe‐Orozco, Wondwossen Tekle, Sara Y. Sabbagh, Syed Zaidi, Marta Olivé‐Gadea, Ayush Prasad, Abid Qureshi, Reade De Leacy, Mohamad Abdalkader, Sergio Salazar‐Marioni, Jazba Soomro, Weston Gordon, Charoskhon Turabova, Aarón Rodríguez-Calienes, Juan Vivanco‐Suarez, Maxim Mokin, Dileep R. Yavagal, Tudor Jovin, Santiago Ortega‐Gutiérrez,
Background Endovascular therapy (EVT) stands as an established and effective intervention for acute ischemic stroke in patients harboring tandem lesions (TLs). However, the optimal anesthetic strategy for EVT in TL patients remains unclear. This study aims to evaluate the impact of distinct anesthetic techniques on outcomes in acute ischemic stroke patients presenting with TLs. Methods Patient-level data, encompassing cases from 16 diverse centers, were aggregated for individuals with anterior circulation ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2024 - BMJ | Journal of NeuroInterventional Surgery
Marino Abrego, Nicolas Acuña‐Perales, Joanna Alfaro‐Shigueto, Jorge Azócar, Ana Rebeca Barragán Rocha, Andrés Baquero, Alejandro Cotto, Jodie J. Darquea, Nelly de Paz, Miguel Donoso, Peter H. Dutton, Luis G. Fonseca, Velkiss Gadea, D. C. Macana García, Meritxell Genovart, Astrid Jiménez, María del Rosario Juárez, Karla Cecilia López Sánchez, Jeffrey C. Mangel, Mayra Leticia Martínez Suzano, Cristina Miranda, Enrique Ocampo, Ana Ordaz Becerra, Clara Ortiz‐Alvarez, Frank V. Paladino, Andrea Pásara-Polack, Sergio Pingo, Rotney Piedra Chacón, Javier Quiñónes, Juan M. Rguez‐Baron, Jorge Carlos Salas Jiménez, H.E. de Alva Salazar, Pilar Santidrián Tomillo, Adriana Laura Sarti Martínez, James R. Spotila, Alejandro Tavera, José Urteaga, Felipe García Vallejo, Elizabeth Vélez, Bryan P. Wallace, Amanda Southwood Williard, Patricia M. Zárate,
Abstract Failure to improve the conservation status of endangered species is often related to inadequate allocation of conservation resources to highest priority issues. Eastern Pacific (EP) leatherbacks are perhaps the most endangered sea turtle population in the world, and continue on a path to regional extinction. To provide coherent, regional conservation targets, we developed a population viability analysis and examined hypothetical scenarios describing effects of conservation activities that ...
Tópico(s): Ichthyology and Marine Biology
2020 - Nature Portfolio | Scientific Reports
Thanh N. Nguyen, Raul G. Nogueira, Muhammad M. Qureshi, Simon Nagel, Jean Raymond, Mohamad Abdalkader, Jelle Demeestere, João Pedro Marto, Sunil A. Sheth, Volker Puetz, Anne Dusart, Patrik Michel, Marc Ribó, Osama O. Zaidat, James E. Siegler, Diogo C Haussen, Daniel Strbian, Hilde Hénon, Mahmoud Mohammaden, Markus Möhlenbruch, Marta Olivé‐Gadea, Ajit S Puri, Simon Winzer, Johannes Kaesmacher, Piers Klein, Liisa Tomppo, François Caparros, João Nuno Ramos, Mouhammad Jumaa, Syed Hassan Ejaz Zaidi, Nicolas Martinez‐Majander, Stefania Nannoni, Lieselotte Vandewalle, Flavio Bellante, Mudassir Farooqui, Sergio Salazar‐Marioni, Pekka Virtanen, Daniel Kaiser, Anke Wouters, Rita Ventura, Jessica Jesser, Adnan Mujanović, Liqi Shu, Alicia C. Castonguay, Zain Mansoor, Zhongming Qiu, Hesham Masoud, Manuel Requena, Erno Peltola, Wei Hu, Eugene Lin, Kanta Tanaka, Charlotte Cordonnier, Daniel Roy, Shadi Yaghi, Davide Strambo, Hiroshi Yamagami, Urs Fischer, Tudor Jovin, Robin Lemmens, Peter A. Ringleb, Santiago Ortega‐Gutiérrez,
There is uncertainty whether patients with large vessel occlusion (LVO) presenting in the late 6-hour to 24-hour time window can be selected for endovascular therapy (EVT) by noncontrast CT (NCCT) and CT angiography (CTA) for LVO detection. We evaluated the clinical outcomes of patients selected for EVT by NCCT compared with those medically managed in the extended time window.
Tópico(s): Peripheral Artery Disease Management
2024 - Lippincott Williams & Wilkins | Neurology
Remedios Calero, Martina G. Gallarza, Sergio Gadea Peña,
En un marco sanitario de fragmentación territorial y cohabitación de gestión pública con colaboración público-privada, tiene sentido analizar y clasificar los departamentos sanitarios, atendiendo a múltiples objetivos: conocer el comportamiento real de los pacientes cuando pueden elegir dónde ser atendidos, adaptar la cartera de ser vicios a las preferencias del paciente y organizar la asistencia sanitaria desde una óptica territorial, considerando si afecta el modelo de gestión. Se utilizan datos ...
Tópico(s): Healthcare Policy and Management
2018 - | Gerencia y Políticas de Salud
Sergio Navarro-Serna, Celia Piñeiro-Silva, Chiara Luongo, John Parrington, Raquel Romar, J. Gadea,
Mosaicism is the most important limitation for one-step gene editing in embryos by CRISPR/Cas9 because cuts and repairs sometimes take place after the first DNA replication of the zygote. To try to minimize the risk of mosaicism, in this study a reversible DNA replication inhibitor was used after the release of CRISPR/Cas9 in the cell. There is no previous information on the use of aphidicolin in porcine embryos, so the reversible inhibition of DNA replication and the effect on embryo development ...
Tópico(s): Animal Genetics and Reproduction
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Sergio Morell-Ortega, Marina Ruiz-Perez, Marién Gadea, Roberto Vivo-Hernando, Gregorio Rubio, Fernando Aparici, María de la Iglesia-Vayá, Gwénaëlle Catheline, Boris Mansencal, Pierrick Coupé, José V. Manjón,
Tópico(s): Vestibular and auditory disorders
2025 - Elsevier BV | NeuroImage
Adnan Mujanović, Daniel Strbian, Jelle Demeestere, João Pedro Marto, Volker Puetz, Raul G. Nogueira, Mohamad Abdalkader, Simon Nagel, Jean Raymond, Marc Ribó, Patrik Michel, Shinichi Yoshimura, Osama O. Zaidat, Simon Winzer, Santiago Ortega‐Gutiérrez, Sunil G. Sheth, James E. Siegler, Anne Dusart, Diogo C Haussen, Hilde Hénon, Bettina L. Serrallach, Mahmoud Mohammaden, Markus Möhlenbruch, Marta Olivé‐Gadea, Ajit S Puri, Nobuyuki Sakai, Piers Klein, Liisa Tomppo, François Caparros, João Nuno Ramos, Mouhammad Jumaa, Syed Zaidi, Tomas Dobrocky, Nicolas Martinez‐Majander, Stefania Nannoni, Flavio Bellante, Aarón Rodríguez-Calienes, Sergio Salazar‐Marioni, Pekka Virtanen, Daniel Kaiser, Rita Ventura, Jessica Jesser, Alicia C. Castonguay, Muhammad M. Qureshi, Hesham Masoud, Milagros Galecio‐Castillo, Manuel Requena, Riikka Lauha, Wei Hu, Eugene Lin, Zhongrong Miao, Daniel Roy, Hiroshi Yamagami, David Seiffge, Davide Strambo, Peter A. Ringleb, Robin Lemmens, Urs Fischer, Thanh N. Nguyen, Johannes Kaesmacher,
The benefit of endovascular therapy (EVT) among stroke patients with large ischemic core (ASPECTS 0-5) in the extended time window outside of trial settings remains unclear. We analyzed the effect of EVT among these stroke patients in real-world settings.
Tópico(s): Venous Thromboembolism Diagnosis and Management
2024 - SAGE Publishing | European Stroke Journal
Marta Ruiz‐Algueró, Belén Alejos, Cristina García Yubero, Melchor Riera Jaume, José Antonio Iribarren, Víctor Asensi, Francisco Pasquau, Carlos Galera, Mario Carrasco, Adolfo Muñoz Carrero, Inmaculada Jarrín, Inés Suárez‐García, Santiago Moreno, Inmaculada Jarrín, David Dalmau, María Luisa Navarro, Maria Gonzalez, José Luís Blanco, Féderico García, Rafael Rubio, José Antonio Iribarren, Félix Gutiérrez, Francesc Vidal, Juan Berenguer, Juan González, Belén Alejos, Víctoria Hernando, Cristina Moreno, Carlos Iniesta, Luis Miguel Garcia Sousa, Nieves Sanz Perez, María Ángeles Muñoz‐Fernández, Isabel García-Merino, Irene Consuegra Fernández, Coral Gómez Rico, Jorge Gallego de la Fuente, Paula Palau Concejo, Joaquín Portilla, Esperanza Merino, Sergio Reus, Vicente Boix, Livia Giner, Carmen Gadea, Irene Portilla, M. Pampliega, Marcos Díez, Juan Carlos Rodrı́guez, José Sánchez‐Payá, Juan Luís Gómez, Jehovana Hernández, María Remedios Alemán Valls, María del Mar Alonso, María Inmaculada Hernández, Felícitas Díaz-Flores, Dácil García, Ricardo Pelazas, Ana López Lirola, José Sanz Moreno, Alberto Arranz Caso, Cristina Hernández Gutiérrez, María Novella Mena, Rafael Rubio, Federico Pulido, Otilia Bisbal, Asunción Hernando, Lourdes Domínguez, David Rial‐Crestelo, Laura Muñoz Bermejo, Mireia Santacreu, José Antonio Iribarren, Julio Arrizabalaga, María José Aramburu, Xabier Camino, Francisco Rodríguez-Arrondo, Miguel Ángel von Wichmann, Lidia Pascual Tomé, Miguel Ángel Goenaga, Ma Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Aitziber Lizardi, Xabier Kortajarena, Félix Gutiérrez, Mar Masiá, Sergio Padilla, Andrés Navarro‐Ruiz, Fernando Montolio, Catalina Robledano, Joan Gregori Colomé, Araceli Adsuar, Rafael J. Pascual, Marta Fernández‐González, Elena García, José Alberto García, Xavier Barber, Roberto Muga, Arantza Sanvisens, Daniel Fuster, Juan Berenguer, Juan Carlos López Bernaldo de Quirós, Isabel Gutiérrez, Margarita Ramírez, Belén Padilla, Paloma Gijón, Teresa Aldámiz‐Echevarría, Francisco Tejerina, F Parras, Pascual Balsalobre, Cristina Díez, Leire Pérez‐Latorre, Francesc Vidal, Joaquín Peraire, Consuelo Viladés, Sergio Veloso, Montserrat Vargas, Miguel López-Dupla, Montserrat Olona, Anna Rull, Esther Rodríguez‐Gallego, Verónica Alba, Marta Montero, José López Aldeguer, Marino Blanes Juliá, María Tasias Pitarch, Iván Castro Hernández, Eva Muñoz, Sandra Cuéllar Tovar, Miguel Salavert, Juan Fernández Navarro, Juan González‐García, Francisco Arnalich, José Ramón Arribas, Ignacio de los Santos, Juan Castro, Luis Escosa, Pedro Herranz, Víctor Hontañón, Silvia García‐Bujalance, Milagros García López‐Hortelano, A. M. Maceira Gonzalez, Luz Martín‐Carbonero, Mario Mayoral, María José Mellado, Rafael Micán, Rocío Montejano, Marisa Montes, V. Moreno, Ignacio Valero, Berta Rodés, Talía Sainz, Elena Sendagorta, Natalia Stella Alcáriz, Eulalia Valencia, José Ramón Blanco, José A. Oteo, Valvanera Ibarra, Luís Metola, Mercedes Sanz, Laura Pérez‐Martínez, Piedad Arazo, Gloria Sampériz, David Dalmau, Ángeles Jaén, Montse Sanmartí, Mireia Cairó, Javier Martínez‐Sanz, Pablo Velli, Roser Font, Mariona Xercavins, Noemí Acedo Alonso, Jesús Repáraz, María Gracia Ruiz de Alda, María Teresa Cano, Beatriz Pierola Ruiz de Galarreta, Ferrán Segura, María José Amengual, Gemma Navarro, Montserrat Sala, Manuel Cervantes, Valentín Pineda, Sònia Calzado, Marta Navarro, Ignacio de los Santos, Jesús Sanz, Ana Salas Aparicio, Cristina Sarriá Cepeda, Lucio Garcia-Fraile Fraile, Enrique Martín Gayo, Santiago Moreno, José L. Casado, Fernando Dronda, Ana Moreno, María Jesús Pérez‐Elías, Cristina Gómez Ayerbe, Carolina Gutiérrez, Nadia Madrid, Santos del Campo, Paloma Martí, Uxua Ansa, Sergio E. Serrano, María Jesús Vivancos, Alfredo Cano, Antonia Alcaraz García, Joaquín Bravo Urbieta, Ángeles Muñoz, María José Alcaraz, Maria del Carmen Villalba, Féderico García, José Hernández, Alejandro Peña, Leopoldo Muñoz, Paz Casas, Marta Álvarez, Natalia Chueca, David Vinuesa García, Clara Martinez-Montes, Jorge del Romero, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Antonio Antela, Elena Losada, Melchor Riera, María Luz Pintos Peñaranda, María Leyes, Ma Angels Ribas, Antoni A Campins, Carmen Vidal, Francisco Fanjul, Javier Murillas, Francisco Homar, Jesús Santos, Crisitina Gómez Ayerbe, Isabel Viciana, Rosario Palacios, Carmen María González, Pompeyo Viciana, Núria Espinosa, Luís F. López‐Cortés, Daniel Podzamczer, Elena Ferrer, Arkaitz Imaz, Juan Tiraboschi, Ana Silva, María Saumoy, Esteban Ribera, Adrián Curran, Julián Olalla, Alfonso del Arco, Javier de la Torre, José Luís Prada, José María García de Lomas Guerrero, Javier Pérez Stachowski, Onofre Juan Martínez, Francisco Jesús Vera, Lorena Martinez‐Gamboa, Josefina García, Begoña Alcaraz, Amaya Jimeno, Angeles Castro Iglesias, Berta Pernas, Álvaro Mena de, Josefa Muñoz, Miren Zuriñe Zubero, Josu Mirena Baraia-Etxaburu, Sofía Ibarra Ugarte, Oscar Luis Ferrero Benéitez, Josefina López de Munain, M Mar Cámara López, Mireia de la Peña, Miriam Lopez, Carlos Galera, Helena Albendín, Aurora Rodríguez Pérez, Asunción Iborra, Antonio Moreno, Maria Angustias Merlos, Asunción Vidal, Concha Amador, Francisco Pasquau, Javier Ena, Concha Benito, Vicenta Fenoll, Concepción Gil Anguita, José Tomás Algado Rabasa, Inés Suárez‐García, Eduardo Malmierca, Patricia González‐Ruano, Dolores Martín Rodrigo, Ma Pilar Ruiz Seco, María Amparo Gómez Vidal, Miguel Alberto de Zárraga, Vicente Estrada Pérez,
The present study sought to describe the use of generic drugs and single-tablet regimen (STR) de-simplification for the treatment of human immunodeficiency virus (HIV) infection among 41 hospitals from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). In June 2018, we collected information on when generic antiretroviral drugs (ARVs) were introduced in the different hospitals, how the decisions to use them were made, and how the information was provided to the patients. Most of the nine available ...
Mary Ann Liebert, Inc.