Produção Nacional
Revisado por pares
Marta Margarete Cestari, Priscilla Maria Menel Lemos, Ciro Alberto de Oliveira Ribeiro, J.R.M. Alves Costa, Émilien Pelletier, Marcos Vinícius Mocellin Ferraro, Mário Sérgio Mantovani, Alberto Sérgio Fenocchio,
The effects of clastogenic or mutagenic agents have rarely been studied in neotropical fish species exposed to contaminated water. In this study, the genetic damage caused by lead in the widely distributed South American fish, Hoplias malabaricus, was assessed using the comet (SCGE) assay and by testing for chromosomal aberrations. Eighteen specimens were acclimatized to laboratory conditions and then chronically exposed to contaminated food by feeding prey (Cyprinus sp.) injected intraperitoneally ...
Tópico(s): Animal Genetics and Reproduction
2004 - Brazilian Society of Genetics | Genetics and Molecular Biology
G. Tofani, Gianni Alvito, Roberto Ambrosini, Pietro Bolli, C. Bortolotti, L. Bruca, Franco Buffa, A. Cattani, G. Comoretto, A. Cremonini, Luca Cresci, N. D’Amico, G. L. Deiana, Antonietta Fara, L. Feretti, Franco Fiocchi, Enrico Flamini, F. Fusi Pecci, G. Grueff, G. Maccaferri, A. Maccaferri, F. Mantovani, Sergio Mariotti, Carlo Migoni, Filippo Messina, Jader Monari, M. Morsiani, M. Murgia, José Musmeci, M. Nanni, Vincenzo Natale, A. Navarrini, M. Negusini, R. Nesti, L. Olmi, A. Orfei, A. Orlati, F. Palla, D. Panella, Claudio Pernechele, S. Pilloni, Tonino Pisanu, Antonio Poddighe, M. Poloni, Angelo Poma, S. Poppi, I. Porceddu, I. Prandoni, J. Roda, Mauro Roma, P. Sarti, A. Scalambra, F. Schilliró, A. Tarchi, Gian Paolo Vargiu, G. Zacchiroli,
We present the status of the Sardinia Radio Telescope (SRT) project, a new general purpose, fully steerable 64 m diameter parabolic radiotelescope capable to operate with high efficiency in the 0.3-116 GHz frequency range. The instrument is the result of a scientific and technical collaboration among three Structures of the Italian National Institute for Astrophysics (INAF): the Institute of Radio Astronomy of Bologna, the Cagliari Astronomy Observatory (in Sardinia,) and the Arcetri Astrophysical ...
Tópico(s): Pulsars and Gravitational Waves Research
2008 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Stefania Mantovani, Sergio Daga, Chiara Fallerini, Margherita Baldassarri, Elisa Benetti, Nicola Picchiotti, Francesca Fava, Anna Gallì, Silvia Zibellini, Mirella Bruttini, Maria Palmieri, Susanna Croci, Sara Amitrano, Diana Alaverdian, Katia Capitani, Simone Furini, Francesca Mari, Ilaria Meloni, Francesca Montagnani, Mario Tumbarello, Ilaria Rancan, Massimiliano Fabbiani, Barbara Rossetti, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Federico Franchi, Maria Antonietta Mazzei, Susanna Guerrini, Edoardo Conticini, Luca Cantarini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli Raffaelli, Marco Feri, Alice Donati, Raffaele Scala, Luca Guidelli, Genni Spargi, Marta Corridi, Cesira Nencioni, Leonardo Croci, Gian Piero Caldarelli, Davide Romani, Paolo Piacentini, Maria Bandini, Elena Desanctis, Silvia Cappelli, Anna Canaccini, Agnese Verzuri, Valentina Anemoli, Manola Pisani, Agostino Ognibene, Alessandro Pancrazzi, Maria Lorubbio, Massimo Vaghi, Antonella d’Arminio Monforte, Federica Gaia Miraglia, Raffaele Bruno, Marco Vecchia, Massimo Girardis, Sophie Venturelli, Stefano Busani, Andrea Cossarizza, Andrea Antinori, Alessandra Vergori, Arianna Emiliozzi, Stefano Rusconi, Matteo Siano, Arianna Gabrieli, Agostino Riva, Daniela Francisci, Elisabetta Schiaroli, Francesco Paciosi, Andrea Tommasi, Pier Giorgio Scotton, Francesca Andretta, Sandro Panese, Stefano Baratti, Renzo Scaggiante, Francesca Gatti, Saverio Giuseppe Parisi, Francesco Castelli, Eugenia Quirós-Roldán, Melania Degli Antoni, Isabella Zanella, Matteo Della Monica, Carmelo Piscopo, Mario Capasso, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Giuseppe Fiorentino, Massimo Carella, Marco Castori, Filippo Aucella, Pamela Raggi, Rita Perna, Matteo Bassetti, Antonio Di Biagio, Maurizio Sanguinetti, Luca Masucci, Alessandra Guarnaccia, Serafina Valente, Oreste De Vivo, Gabriella Doddato, Mirjam Lista, Giada Beligni, Floriana Valentino, Kristina Zguro, Rossella Tita, Annarita Giliberti, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Francesca Ariani, Laura Di Sarno, Elena Bargagli, Marco Mandalà, Alessia Giorli, Lorenzo Salerni, Patrizia Zucchi, Pierpaolo Parravicini, E. Menatti, Tullio Trotta, Ferdinando Giannattasio, Gabriella Coiro, Fabio Lena, Leonardo Gianluca Lacerenza, Cristina Mussini, Enrico Martinelli, Luisa Tavecchia, Mary Ann Belli, Lia Crotti, Gianfranco Parati, Maurizio Sanarico, Francesco Raimondi, Filippo Biscarini, Alessandra Stella, Tiziana Bachetti, Maria Teresa La Rovere, Serena Ludovisi, Maurizio Bussotti, Simona Dei, Sabrina Ravaglia, Rosangela Artuso, Elena Andreucci, Giulia Gori, Angelica Pagliazzi, Erika Fiorentini, Antonio Perrella, Francesco Bianchi, Paola Bergomi, E Catena, Riccardo Colombo, Sauro Luchi, Giovanna Morelli, Paola Petrocelli, Sarah Iacopini, Sara Modica, Silvia Baroni, Francesco Vladimiro Segala, Marco Falcone, Giusy Tiseo, Chiara Barbieri, Tommaso Matucci, Davide Grassi, Claudio Ferri, Franco Marinangeli, Francesco Brancati, M. A. Vincenti, Valentina Borgo, Stefania Lombardi, Mirco Lenzi, Massimo Antonio Di Pietro, Francesca Vichi, Benedetta Romanin, Letizia Attala, Cecília Costa, Andrea Gabbuti, Roberto Menè, Marta Colaneri, Patrizia Casprini, Giuseppe Merla, Gabriella Maria Squeo, Marcello Maffezzoni, Elisa Frullanti, Mario U. Mondelli, Alessandra Renieri,
Abstract Toll-like receptors (TLR) are crucial components in the initiation of innate immune responses to a variety of pathogens, triggering the production of pro-inflammatory cytokines and type I and II interferons, which are responsible for innate antiviral responses. Among the different TLRs, TLR7 recognizes several single-stranded RNA viruses including SARS-CoV-2. We and others identified rare loss-of-function variants in X-chromosomal TLR7 in young men with severe COVID-19 and with no prior ...
Tópico(s): Immune Cell Function and Interaction
2021 - Springer Nature | Genes and Immunity
Antonella Caminati, Fabiana Madotto, Sara Conti, Giancarlo Cesana, LG Mantovani, Sergio Harari,
Tópico(s): Occupational and environmental lung diseases
2021 - Springer Science+Business Media | Internal and Emergency Medicine
Produção Nacional
Revisado por pares
Antonio C. Ribeiro-Filho, Débora Levy, Jorge L.M. Ruiz, Marluce da Cunha Mantovani, Sérgio Paulo Bydlowski,
Hematopoiesis is the main function of bone marrow. Human hematopoietic stem and progenitor cells reside in the bone marrow microenvironment, making it a hotspot for the development of hematopoietic diseases. Numerous alterations that correspond to disease progression have been identified in the bone marrow stem cell niche. Complex interactions between the bone marrow microenvironment and hematopoietic stem cells determine the balance between the proliferation, differentiation and homeostasis of ...
Tópico(s): Acute Myeloid Leukemia Research
2019 - Multidisciplinary Digital Publishing Institute | Cells
Produção Nacional
Revisado por pares
Efigênia Passarelli Mantovani, Sérgio Roberto de Lucca, Anita Liberalesso Néri,
Resumo Objetivos: Investigar os significados atribuídos por idosos aos conceitos de velhice saudável e de ser feliz na velhice, bem como as associações entre os significados e suas avaliações sobre satisfação global e referenciada a domínios. Método: Esta investigação foi realizada a partir dos dados de um estudo multicêntrico, de corte transversal. As emissões verbais provenientes de amostras representativas de idosos comunitários (N=1.242, com 65 anos e mais), registradas no banco de dados de duas ...
Tópico(s): Psychological Well-being and Life Satisfaction
2016 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Revista Brasileira de Geriatria e Gerontologia
Chiara Liberati, Maria Rosaria, Paola Secco, Claudio Santoro, Roberto Mantovani, Sergio Ottolenghi, Antonella Ronchi,
The nuclear receptor COUP-TFII was recently shown to bind to the promoter of the ε- and γ-globin genes and was identified as the nuclear factor NF-E3. Transgenic experiments and genetic evidence from humans affected with hereditary persistence of fetal hemoglobin suggest that NF-E3 may be a repressor of adult ε and γ expression. We show that, on the ε-promoter, recombinant COUP-TFII binds to two sites, the more downstream of which overlaps with an NF-Y binding CCAAT box. Binding occurs efficiently ...
Tópico(s): RNA modifications and cancer
2001 - Elsevier BV | Journal of Biological Chemistry
Barbára Giglioni, Paola Comi, Antonella Ronchi, Roberto Mantovani, Sergio Ottolenghi,
Using in vitro assays, we show that nuclear proteins related to the Sp1 and GT-1 factors bind to a CACCC box sequence in the human beta-globin enhancer, adjacent to binding sites for the erythroid-specific factor NFE1 and the ubiquitous factor CP1. The same proteins are known to bind to the proximal, but not to the distal, CACCC, box in the human beta-globin promoter. A C G mutation in the promoter CACCC box, known to cause beta-thalassemia, greatly decreases protein binding to the CACCC box; the ...
Tópico(s): Epigenetics and DNA Methylation
1989 - Elsevier BV | Biochemical and Biophysical Research Communications
Clara Camaschella, Anna Serra, Giuseppe Saglio, Montserrat Baiget, Nicoletta Malgaretti, Roberto Mantovani, Sergio Ottolenghi,
Abstract Spanish delta beta zero-thalassemia, a mild thalassemic condition characterized by increased level of hemoglobin (Hb) F production during adult life, is known to be due to a large deletion starting within the beta globin gene cluster and extending beyond the 3′ breakpoint of any other similar deletional defects so far identified. By molecular cloning and by genomic mapping we now demonstrate that the deletion of Spanish delta beta zero-thalassemia ends at approximately 11 and 17 kilobases ( ...
Tópico(s): Iron Metabolism and Disorders
1987 - Elsevier BV | Blood
A. Mantovani, Sergio Cenini, R. Heintz, Donald E. Morris,
Di-μ-Chloro-Bis[Tricarbonylchloro-Ruthenium(II)] A. Mantovani, A. Mantovani Cattedra di Chimica, Facoltà d'Ingegneria, Via Marzolo 9, 35100 Padova, Italy.Search for more papers by this authorS. Cenini, S. Cenini Istituto di Chimica Generale, Centro C.N.R., Via G. Venezian 21, 20133 Milano, Italy.Search for more papers by this authorR. M. Heintz, R. M. Heintz Corporate Research Department, Monsanto Co., St. Louis, Mo. 63166.Search for more papers by this authorD. E. Morris, D. E. Morris Corporate ...
Tópico(s): Inorganic and Organometallic Chemistry
1976 - Wiley | Inorganic syntheses
A. Mantovani, Sergio Cenini, Brian R. James, D. V. Plackett,
Dodecacarbonyltriruthenium A. Mantovani, A. Mantovani Cattedra di Chimica, Facoltà di Ingegneria, Via Marzolo 9, 35100 Padova, Italy.Search for more papers by this authorS. Cenini, S. Cenini Centro di Studio per la sintesi e la struttura dei composti dei metalli di transidone nei bassi stati di ossidazione del C.N.R. and Istituto di Chimica Generale dell'Università, Via G. Venezian 21, 20133 Milano, Italy.Search for more papers by this authorB. R. James, B. R. James Department of Chemistry, University ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
1976 - Wiley | Inorganic syntheses
C Camaschella, A Serra, G Saglio, M Baiget, N Malgaretti, Roberto Mantovani, Sergio Ottolenghi,
Spanish delta beta zero-thalassemia, a mild thalassemic condition characterized by increased level of hemoglobin (Hb) F production during adult life, is known to be due to a large deletion starting within the beta globin gene cluster and extending beyond the 3′ breakpoint of any other similar deletional defects so far identified. By molecular cloning and by genomic mapping we now demonstrate that the deletion of Spanish delta beta zero-thalassemia ends at approximately 11 and 17 kilobases (kb) downstream ...
Tópico(s): Iron Metabolism and Disorders
1987 - Elsevier BV | Blood
Produção Nacional
Revisado por pares
Victória Akemi Itakura Silveira, Renata Katsuko Takayama Kobayashi, Admilton Gonçalves de Oliveira, Mário Sérgio Mantovani, Gerson Nakazato, Maria Antonia Pedrine Colabone Celligoi,
The objective of this study was to evaluate the antibacterial effect of sophorolipid in combination with lactic acid against relevant bacteria isolated from the poultry industry. Staphylococcus aureus, Listeria monocytogenes, Salmonella enterica, and Escherichia coli were isolated from chicken meat and antibacterial tests with sophorolipid and lactic acid were performed. Checkerboard, time-kill, and scanning electron microscopy analyses were used to confirm the antibacterial action and the combined ...
Tópico(s): Ginger and Zingiberaceae research
2021 - Springer Nature | Brazilian Journal of Microbiology
Produção Nacional
Revisado por pares
Sandra Regina Lepri, Daniele Sartori, Simone Cristine Semprebon, Adrivânio Baranoski, Giuliana Castello Coatti, Mário Sérgio Mantovani,
Background: Genistein (5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is the most abundant isoflavone in soybean, which has been associated with a lower risk of development of cancer and cardiovascular diseases. Of particular interest regarding cancer preventive properties of flavonoids is their interaction with cytochrome P450 enzymes (CYPs). However, contradictory data report the effect of genistein on expression of СYPs enzymes. Objective: The aim of this study was to investigate the ...
Tópico(s): Glutathione Transferases and Polymorphisms
2018 - Bentham Science Publishers | Drug Metabolism Letters
Produção Nacional
Revisado por pares
Flavia Maria Lima Cavalcante, Igor Vivian de Almeida, Elisângela Düsman, Mário Sérgio Mantovani, Verônica Elisa Pimenta Vicentini,
Gentisic acid (GA) exhibits antioxidant, anti-inflammatory, and antibiotic activities. This substance can be found in citrus fruits, grapes, olive oil, and peas. Considering that there are few studies in the literature on the toxicity of GA, the present work aimed to investigate its cytotoxic, mutagenic, and antimutagenic activities on HTC cells. GA was diluted in culture medium at the final concentration of 0.08, 0.16, 0.8, 1.6, and 8 μg/mL. The cytotoxicity was determined by the MTT assay and Trypan ...
Tópico(s): Plant tissue culture and regeneration
2017 - Taylor & Francis | Drug and Chemical Toxicology
Produção Nacional
Revisado por pares
João Renato Pesarini, Rodrigo Juliano Oliveira, Lucas Roberto Pessatto, Andréia Conceição Milan Brochado Antoniolli‐Silva, Ingrid Felicidade, Nance Beyer Nardi, Melissa Camassola, Mário Sérgio Mantovani, Lúcia Regina Ribeiro,
Studies have shown that metabolic disorders, serum inflammatory markers and weight gain (obesity) are correlated with vitamin D deficiency. Therefore, the present study correlated the serum calcidiol (s25(OH)D3) levels in a sample of individuals from southern Brazil with variables related to metabolic disorders, obesity and lifestyle habits and assessed the cytotoxic effect of calcitriol on adipose tissue-derived mesenchymal stem cells (ADSCs). The results showed a 79.23% prevalence of hypovitaminosis ...
Tópico(s): Eating Disorders and Behaviors
2017 - Elsevier BV | Biomedicine & Pharmacotherapy
Produção Nacional
Giuliana Castello Coatti, Miriam Frangini, Marcos Valadares, Juliana Gomes, Natalia Oliveira de Lima, Natale Cavaçana, Amanda F. Assoni, Mayra Pelatti, Alexander Birbrair, Antonio Carlos Pedroso de Lima, Júlio M. Singer, Francisco Marcelo Monteiro da Rocha, Giovani L. Silva, Mário Sérgio Mantovani, Lúcia Inês Macedo‐Souza, M Ferrari, Mayana Zatz,
Tópico(s): Mesenchymal stem cell research
2017 - Springer Science+Business Media | Stem Cell Reviews and Reports
Produção Nacional
Revisado por pares
Bruna Isabela Biazi, Thalita Alves Zanetti, Adrivânio Baranoski, Amanda Cristina Corveloni, Mário Sérgio Mantovani,
Of late, many studies are attempting to find new molecules with anticancer properties, especially those with the capability to inhibit cell growth. The aim of this work was to evaluate nerolidol, a plant-based compound, as its cytotoxicity, genotoxicity, antiproliferative and apoptotic induction, cell cycle, mitochondrial membrane potential and RT-qPCR of transcripts related to those pathways in the human hepatocellular carcinoma cell line (HepG2/C3A). Only cis-nerolidol (C-NER) demonstrated cytotoxicity ( ...
Tópico(s): Cancer-related Molecular Pathways
2017 - Wiley | Basic & Clinical Pharmacology & Toxicology
Produção Nacional
Revisado por pares
Géssica Dutra Gonçalves, Simone Cristine Semprebon, Bruna Isabela Biazi, Mário Sérgio Mantovani, Glaura Scantamburlo Alves Fernandes,
Leydig cells are the major testosterone-producing cells of the male reproductive system, and damage to these cells can impair fertility of men. Bisphenol A (BPA) is one of the chemicals with the highest volume of production worldwide. The aim of this study was to evaluate the effects of BPA on the growth, viability, and testosterone production of TM3 murine Leydig cells after exposure to BPA for 24 or 48 h. BPA reduced testosterone production, cell viability and cell growth in a concentration-dependent ...
Tópico(s): Toxic Organic Pollutants Impact
2017 - Elsevier BV | Reproductive Toxicology
Produção Nacional
Revisado por pares
Joanna M. Tucker Lima, Denis Valle, Evandro Mateus Moretto, Sérgio Mantovani Paiva Pulice, Nadia Lucia Zuca, Daniel Rondinelli Roquetti, Liviam Elizabeth Cordeiro Beduschi, Amanda Salles Praia, Claudia Parucce Franco Okamoto, Vinícius Carvalhaes, Evandro Albiach Branco, Bruna Barbezani, Emily Labandera, Kelsie Timpe, David Kaplan,
Abstract Recognized as one of the world’s most vital natural and cultural resources, the Amazon faces a wide variety of threats from natural resource and infrastructure development. Within this context, rigorous scientific study of the region’s complex social-ecological system is critical to inform and direct decision-making toward more sustainable environmental and social outcomes. Given the Amazon’s tightly linked social and ecological components and the scope of potential development impacts, ...
Tópico(s): Hydropower, Displacement, Environmental Impact
2016 - Nature Portfolio | Scientific Data
Produção Nacional
Andressa Megumi Niwa, Natália Aparecida de Paula, Diogo Campos Vesenick, Daniele Sartori, Edson Luis Maistro, Lúcia Regina Ribeiro, Mário Sérgio Mantovani,
The dibenzylbutyrolactone lignan (-)-cubebin, which is extracted from the seeds of the pepper Piper cubeba, has shown promise as an anti-inflammatory, analgesic, leishmanicidal, antiproliferative, and trypanocidal compound. Given the therapeutic potential of (-)-cubebin, this study aimed to investigate its safety profile by analyzing cytotoxicity, mutagenicity, cell proliferation kinetics, induction of apoptosis, and expression of pro-apoptotic genes in human colon adenocarcinoma cells (HT29) exposed to (-)- ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2016 - Taylor & Francis | Journal of Toxicology and Environmental Health
Produção Nacional
Revisado por pares
Jaqueline Bianchi, Mário Sérgio Mantovani, Maria Aparecida Marin‐Morales,
Based on the concentration of Malathion used in the field, we evaluated the genotoxic potential of low concentrations of this insecticide on meristematic and F1 cells of Allium cepa and on rat hepatoma tissue culture (HTC cells). In the A. cepa, chromosomal aberrations (CAs), micronuclei (MN), and mitotic index (MI) were evaluated by exposing the cells at 1.5, 0.75, 0.37, and 0.18 mg/mL of Malathion for 24 and 48 hr of exposure and 48 hr of recovery time. The results showed that all concentrations were ...
Tópico(s): Insect Resistance and Genetics
2015 - Elsevier BV | Journal of Environmental Sciences
Produção Nacional
Revisado por pares
Rodrigo Juliano Oliveira, Mário Sérgio Mantovani, João Renato Pesarini, M.O. Mauro, A.F. da Silva, T.R. Souza, L.R. Ribeiro,
The compounds 6-dimethylaminopurine (6-DMAP) and cyclohexamide (CHX) are currently used to stimulate the development ©FUNPEC-RP www.funpecrp.com.brGenetics and Molecular Research 14 (1): 834-849 (2015) 6-DMAP and CHX alter reproduction of embryos produced by nuclear transfer in the production of cloned mammals with a great deal success.This study investigated the effects of 6-DMAP and CHX in vivo using biological assays to evaluate reproductive performance in females, teratogenesis, and mutagenesis.The ...
Tópico(s): Reproductive Biology and Fertility
2015 - Research Foundation of Ribeirão Preto | Genetics and Molecular Research
Produção Nacional
Revisado por pares
Simone Cristine Semprebon, Lilian Areal Marques, Gláucia Fernanda Rocha D’Epiro, Elaine Aparecida de Camargo, Glenda Nicioli da Silva, Andressa Megumi Niwa, Fernando Macedo, Mário Sérgio Mantovani,
(R)-goniothalamin (R-GNT) is a styryl lactone that exhibits antiproliferative property against several tumor cell lines. (S)-goniothalamin (S-GNT) is the synthetic enantiomer of R-GNT, and their biological properties are poorly understood. The aim of this study was to evaluate the antiproliferative mechanisms of (R)-goniothalamin and (S)-goniothalamin in MCF-7 breast cancer cells and HB4a epithelial mammary cells. To determine the mechanisms of cell growth inhibition, we analyzed the ability of R-GNT ...
Tópico(s): Synthesis and Biological Activity
2015 - Elsevier BV | Toxicology in Vitro
Produção Nacional
Revisado por pares
Rodrigo Juliano Oliveira, João Renato Pesarini, Maria José Sparça Salles, Tatiane Yumi Nakamura Kanno, Ana Carolina dos Santos Lourenço, Véssia da Silva Leite, Ariane Fernanda da Silva, Hevenilton José Matiazi, Lúcia Regina Ribeiro, Mário Sérgio Mantovani,
β-glucan is a well-known polysaccharide for its chemopreventive effect. This study aimed to evaluate the chemopreventive ability of β-glucan in somatic and germ cells through the dominant lethal and micronucleus assays, and its influence on the reproductive performance of male mice exposed to cyclophosphamide. The results indicate that β-glucan is capable of preventing changes in DNA in both germ cells and somatic ones. Changes in germ cells were evaluated by the dominant lethal assay and showed ...
Tópico(s): Ovarian function and disorders
2014 - Brazilian Society of Genetics | Genetics and Molecular Biology
Produção Nacional
Revisado por pares
M.O. Mauro, João Renato Pesarini, Maria Aparecida Marin‐Morales, Maria Tereza Ferreira Duenhas Monreal, Antônio Carlos Duenhas Monreal, Mário Sérgio Mantovani, Rodrigo Juliano Oliveira,
This study evaluated the mutagenicity and antimutagenicity of inulin in a chromosomal aberration assay in cultures of the meristematic cells of Allium cepa. The treatments evaluated were as follows: negative control--seed germination in distilled water; positive control--aqueous solution of methyl methanesulfonate (10 μg/mL MMS); mutagenicity--aqueous solutions of inulin (0.015, 0.15, and 1.50 μg/mL); and antimutagenicity--associations between MMS and the different inulin concentrations. The antimutagenicity ...
Tópico(s): Plant Pathogens and Resistance
2014 - Research Foundation of Ribeirão Preto | Genetics and Molecular Research
Produção Nacional
Revisado por pares
Dalita G. S. M. Cavalcante, Natara Dias Gomes da Silva, Juliana Cristina Marcarini, Mário Sérgio Mantovani, Maria Aparecida Marin‐Morales, Cláudia Bueno dos Reis Martinez,
Transesterification has proved to be the best option for obtaining biodiesel and, depending on the type of alcohol used in the reaction, the type of biodiesel may be methyl ester or ethyl ester. Leaking biodiesel can reach water bodies, contaminating aquatic organisms, particularly fish. The objective of this study was to determine whether the soluble fraction of biodiesel (Bd), produced by both the ethylic (BdEt) and methylic (BdMt) routes, can cause cytotoxic, biochemical and genotoxic alterations ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2014 - Elsevier BV | Toxicology in Vitro
Produção Nacional
Revisado por pares
Sandra Regina Lepri, Leonardo Campos Zanelatto, Patrícia Benites Gonçalves da Silva, Daniele Sartori, Lúcia Regina Ribeiro, Mário Sérgio Mantovani,
Tópico(s): Cancer-related gene regulation
2014 - Springer Science+Business Media | Human Cell
Produção Nacional
Revisado por pares
M.O. Mauro, Maria Tereza Ferreira Duenhas Monreal, M.T.P. Silva, João Renato Pesarini, Mário Sérgio Mantovani, Lúcia Regina Ribeiro, Jane Bandeira Dichi, Clísia Mara Carreira, Rodrigo Juliano Oliveira,
The incidence of colorectal cancer is growing worldwide.The characterization of compounds present in the human diet that can prevent the occurrence of colorectal tumors is vital.The oligosaccharide inulin is such a compound.The aim of this study was to evaluate the antigenotoxic, antimutagenic and anticarcinogenic effects of inulin in vivo.Our study ©FUNPEC-RP www.funpecrp.com.
Tópico(s): Pharmacological Effects of Natural Compounds
2013 - Research Foundation of Ribeirão Preto | Genetics and Molecular Research
Produção Nacional
Ana Paula Peron, Rosinete Gonçalves Mariucci, Igor Vivian de Almeida, Elisângela Düsman, Mário Sérgio Mantovani, Verônica Elisa Pimenta Vicentini,
St. John's wort (Hypericum perforatum L.) is an herbaceous plant that is native to Europe, West Asia and North Africa and that is recognized and used worldwide for the treatment of mild and moderate depression. It also has been shown to be therapeutic for the treatment of burns, bruises and swelling and can be used for its wound healing, antiviral, antimicrobial, antioxidant, analgesic, hepato-protective and anxiolytic properties. The aim of this study was to evaluate the potential cytotoxic, mutagenic ...
Tópico(s): Plant tissue culture and regeneration
2013 - BioMed Central | BMC Complementary and Alternative Medicine