Ayu Watanabe, Masahiro Kamata, Teruo Shimizu, Hideaki Uchida, Emi Sakurai, Shoya Suzuki, Hideyuki Nakajima, Yoshiko Niimura, Makoto Ito, Shota Egawa, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Yayoi Tada,
Psoriasis is characterized by increased dermal vascularity, indicating that aberrant angiogenesis is associated with the pathogenesis of psoriasis. Data on angiogenesis-related factors in psoriasis patients are limited. We explored serum levels of angiogenesis-related factors in patients with psoriasis, and investigated their association with clinical severity and laboratory data. Psoriasis patients visiting our hospital from April 2013 to April 2018 and healthy controls were included in this study. ...
Tópico(s): Lymphatic System and Diseases
2022 - Wiley | The Journal of Dermatology
Kikuyasu Nakamura, S Shoya, Yasuyuki NAKAJIMA, Kameo SHIMURA, Shingo Ito,
[in Japanese]
Tópico(s): Milk Quality and Mastitis in Dairy Cows
1982 - Japanese Society of Veterinary Science | The Japanese Journal of Veterinary Science
Daisuke Akazawa, Hirofumi Ohashi, Takayuki Hishiki, Takeshi Morita, Shoya Iwanami, Kwang Su Kim, Yong Dam Jeong, Eun‐Sil Park, Michiyo Kataoka, Kaho Shionoya, Junki Mifune, Kana Tsuchimoto, Shinjiro Ojima, Aa Haeruman Azam, Shogo Nakajima, Hyeongki Park, Tomoki Yoshikawa, Masayuki Shimojima, Kotaro Kiga, Shingo Iwami, Ken Maeda, Tadaki Suzuki, Hideki Ebihara, Yoshimasa Takahashi, Koichi Watashi,
Mpox virus (MPXV) is a zoonotic orthopoxvirus and caused an outbreak in 2022. Although tecovirimat and brincidofovir are approved as anti-smallpox drugs, their effects in mpox patients have not been well documented. In this study, by a drug repurposing approach, we identified potential drug candidates for treating mpox and predicted their clinical impacts by mathematical modeling.
Tópico(s): Plant Virus Research Studies
2023 - Oxford University Press | The Journal of Infectious Diseases
Nobuo Goto, Kiyoshi Miura, Kenkichi IMAMURA, S Shoya, Y Nakajima, S Homma, Y Noda,
Tópico(s): Mycotoxins in Agriculture and Food
1980 - | JSM Mycotoxins
Shotaro Takeuchi, Yasuyuki NAKAJIMA, S Shoya, TSUNEJI SUTO,
Two strains of Staphylococcus aureus were examined for behavior in the cutaneous tissue of mice by the fluorescent antibody technique, hematoxylin and eosin staining. When about 10(8) viable cells of an alpha-hemolysin-producing strain (Wood 46) were inoculated subcutaneously into a mouse, they multiplied in the subcutaneous tissue of the mouse and gradually entered the corium to produce alpha-hemolysin and nuclease. Edematous and necrotic lesions were observed in the cutaneous tissue where the organisms ...
Tópico(s): Biochemical and Structural Characterization
1978 - Wiley | Microbiology and Immunology
Shotaro Takeuchi, Yasuyuki NAKAJIMA, S Shoya, TSUNEJI SUTO,
黄色ブドウ球菌の生菌で免疫したマウスの皮下に鶏由来のCH-19株を攻撃し, 攻撃菌の行動と感染防御を調べた. この実験には, CH-19株のプロテアーゼによって起こる皮膚融解を感染の指標として用いた. その結果, 感染防御効果がCH-19株および異類株で免疫したマウスで認められた. これらの免疫マウスにおいては, 攻撃菌は浸潤白血球によって容易に貧食され, 菌の増殖および菌体外活性物質の産生が制限された. また, これらの免疫マウスにおいて, 菌体およびα溶血毒に対する抗体が証明された. 一方, このような防御効果は菌体およびα溶血毒に対する家兎抗血清で免疫したマウスにおいても認められた. 特に, 抗α溶血毒血清で免疫したマウスでの菌の行動および組織変化は, 生菌マウスでの成績と類似していた. このことから, α溶血毒に対する抗体が感染防御に重要な役割を演じていると考えられた.
Tópico(s): Antimicrobial Peptides and Activities
1980 - Japanese Society of Veterinary Science | The Japanese Journal of Veterinary Science
H. Seki, Shoya Yamazaki, Masahisa Otsuka, Masakazu Tane, Soong Keun Hyun, Hideo Nakajima,
Tension and compression fatigue property was investigated for lotus-type porous copper possessing cylindrical pores aligned in one direction. The cyclic stress was applied in the direction parallel and perpendicular to the longitudinal axis of the pores. It was found that the fatigue strength at finite life of lotus-type porous copper is lower than that of nonporous copper, and the strength in the direction parallel to the longitudinal axis of the pores is higher than that in the perpendicular direction.
Tópico(s): Metal Forming Simulation Techniques
2006 - Trans Tech Publications | Materials science forum
Hideyuki Nakajima, Masahiro Kamata, Yoshiki Okada, Shoya Suzuki, Makoto Ito, Ayu Watanabe, Shota Egawa, Chika Chijiwa, Azusa Hiura, Yayoi Tomura, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Yayoi Tada,
ABSTRACT Dupilumab, an anti‐interleukin (IL)‐4 receptor α‐antibody, was approved in 2018 for the treatment of moderate‐to‐severe atopic dermatitis (AD) in Japan. Although real‐world data have accumulated on the effectiveness and safety of dupilumab in patients with AD in the short term, real‐world data on its long‐term use are limited. In this study, we retrospectively investigated its effectiveness, safety and laboratory data in patients with AD who received dupilumab for 3 years. All adult patients ...
Tópico(s): Asthma and respiratory diseases
2024 - Wiley | Experimental Dermatology