Kunihiro Tsukasaki, Yasuaki Yamada, Shu‐ichi Ikeda, Masao Tomonaga,
... JapanSearch for more papers by this authorShuichi Ikeda, Shuichi Ikeda Department of Hematology, Atomic Disease Institute, Nagasaki University ... JapanSearch for more papers by this authorShuichi Ikeda, Shuichi Ikeda Department of Hematology, Atomic Disease Institute, Nagasaki University ...
Tópico(s): Fungal Infections and Studies
1994 - Wiley | International Journal of Cancer
Naoki Sadamori, Shuichi Ikeda, Toshihiro Yamaguchi, Mariko Mine, S Hakariya, Hirofumi Kinoshita, Kuniaki Hayashi, Tatsufumi Nakamura, Shigenobu Nagataki, Michito Ichimaru,
Serum deoxythymidine kinase (TK) was measured in 15 patients with the acute type of adult T-cell leukemia (ATL), in 4 with chronic ATL, in 10 with lymphoma type ATL, in 9 with pre-ATL, in 11 with human T-cell leukemia virus type I (HTLV-I) associated with myelopathy (HAM) and in 19 HTLV-I carriers. All these patients were positive for anti-HTLV antibody. The level of TK in pretreatment serum was highest in acute ATL (15.6–1600 U/1, median 107 U/1). It was elevated in chronic ATL (5.4–55.0 U/1, median ...
Tópico(s): Animal Disease Management and Epidemiology
1991 - Elsevier BV | Leukemia Research
Hirokazu Nagai, Tomohiro Kinoshita, Jun Imamura, Yoshinori Murakami, Kenshi Hayashi, Kiyoshi Mukai, Shuichi Ikeda, Kensei Tobinai, Hidehiko Saito, M Shimoyama, Kunitada Kunitada,
Abnormalities of p53 mRNA in adult T‐cell leukemia (ATL) were analyzed using reverse transcription‐polymerase chain reaction‐single strand conformation polymorphism analysis. Mutations were present in two of 12 ATL patients studied, but not in 3 cell lines immortalized by human T cell leukemia virus type 1 (HTLV‐1) infection in vitro. Direct sequencing analysis of the p53 gene from these two patients revealed missense point mutations at codon 153 (arginine to histidine) or codon 220 (cysteine to tyrosine), ...
Tópico(s): Animal Disease Management and Epidemiology
1991 - Oxford University Press | Japanese Journal of Cancer Research
Osamu Shinzato, Hiroshi Shiku, Yasuhiko Nagata, Eiichi Nakayama, Shimeru Kamihira, Shuichi Ikeda, Hisayoshi Kondo, T Kanda,
Abstract Two distinct diseases, adult T‐cell leukemia (ATL) and HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), develop in a minor population of HTLV‐1 carriers. We examined the relationship between the viral genome dose in the peripheral‐blood mononuclear cells and the serological response in HTLV‐1 carriers and patients with HAM/TSP. The antibody titer to HTLV‐1 gag and env proteins, as well as the frequency of an antibody response to viral protein p40 tax and the titer, increased ...
Tópico(s): Vector-Borne Animal Diseases
1993 - Wiley | International Journal of Cancer
Hirokuni Taguchi, K Kinoshita, Kiyoshi Takatsuki, Masao Tomonaga, Koichi Araki, Naomichi Arima, Shuichi Ikeda, Koji Uozumi, Hidehisa Kohno, Fumio Kawano, Hiroshi Kikuchi, Hironori Takahashi, Kazuo Tamura, S Chiyoda, Hiroyuki Tsuda, H Nishimura, Takafumi Hosokawa, Hiromitsu Matsuzaki, Saburo Momita, Osamu Yamada, Isao Miyoshi,
An intensive combination chemotherapy regimen supported by granulocyte colony-stimulating factor (G-CSF) was evaluated in adult T-cell leukemia/lymphoma (ATLL) patients in a multiinstitutional, cooperative study. Vincristine 1 mg/m2 i.v. day 1, Adriamycin 40 mg/m2 i.v. day 1, cyclophosphamide 400 mg/m2 i.v. day 1, prednisolone 40 mg/m2 i.v. days 1 to 3 and 8 to 10, etoposide 35 mg/m2 i.v. days 1 to 8, vindesine 2 mg/m2 i.v. day 8, ranimustine 50 mg/m2 i.v. day 8, mitoxantrone 7 mg/m2 i.v. day 8, and ...
Tópico(s): Animal Disease Management and Epidemiology
1996 - Lippincott Williams & Wilkins | Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology
Kunihiro Yoshida, Kenichi Furihata, Shin-ichi Takeda, Akinori Nakamura, Kanji Yamamoto, Hiroshi Morita, Shuichi Hiyamuta, Shuichi Ikeda, Norikazu Shimizu, Nobuo Yanagisawa,
Tópico(s): Ion channel regulation and function
1995 - Nature Portfolio | Nature Genetics
Takahiro Itoyama, Naoki Sadamori, Seiji Tokunaga, I. Sasagawa, Hideo Nakamura, Ei-ichi Yao, Tohru Jubashi, Yasuaki Yamada, Shuichi Ikeda, Michito Ichimaru,
Recently, the chromosome 14q11 anomaly has been reported to be specific to adult T-cell leukemia (ATL), and this anomaly has also been confirmed in the preleukemic state of adult T-cell leukemia (pre-ATL) patients. Because the cytogenetic abnormality at the stage of human T-cell leukemia virus type I (HTLV-I) carrier remains uncertain, we performed cytogenetic studies of lymphocytes stimulated with phytohemagglutinin in three HTLV-I carriers and three non-HTLV-I carriers in an ATL family. As a result, ...
Tópico(s): Animal Disease Management and Epidemiology
1990 - Elsevier BV | Cancer Genetics and Cytogenetics
Seiichi Inoue, Hiroshi Ikeda, Shuichi Sato, Kiyohiro Horie, Tomomi Ota, Osamu Miyamoto, Kikumasa Sato,
... 4'R,8'R)-.alpha.-tocopherolSeiichi Inoue, Hiroshi Ikeda, Shuichi Sato, Kiyohiro Horie, Tomomi Ota, Osamu Miyamoto, and ...
Tópico(s): Organic Chemistry Cycloaddition Reactions
1987 - American Chemical Society | The Journal of Organic Chemistry
Kiyohiro Hamatani, Yasuhiko Nagata, Masumi Abe, Kuniko Abe, H Toki, Shuichi Ikeda, Eiichi Nakayama, Hiroshi Shiku,
Twenty‐three cases of non‐Hodgkin's lymphoma (NHL) were analyzed for expression of ras genes by in situ hybridization utilizing biotinylated DNA probes. Increased expression of Ki‐ ras , Ha‐ ras and N‐ ras genes was observed in 12 cases, 6 cases and 1 case of NHL, respectively. Genomic DNA extracted from these 23 cases of NHL was region‐specifically amplified by means of polymerase chain reaction to examine the presence of point mutations at the 12th, 13th and 61st codons of Ki‐, Ha‐ and N‐ ras genes. ...
Tópico(s): HER2/EGFR in Cancer Research
1989 - Oxford University Press | Japanese Journal of Cancer Research
J. Mark Ramseyer, Minoru Nakazato,
... doi.org/10.1017/als.2017.7Daisuke Mori, Shuichi Takahashi, Yasuhiro Ikeda Compensation, punishment, and deterrence: a survey on the ...
1989 - University of Chicago Press | The Journal of Legal Studies
Hideo SHOJI, Atsushi Saima, Kazuyuki Shiino, Ikeda Shuichi,
Tópico(s): Biodiesel Production and Applications
1992 - | SAE technical papers on CD-ROM/SAE technical paper series
Souichi Yanamoto, Shin‐ichi Yamada, Hidenori Takahashi, Goro Kawasaki, Hisazumi Ikeda, Takeshi Shiraishi, Shuichi Fujita, Tohru Ikeda, Izumi Asahina, Masahiro Umeda,
Locoregional recurrence of oral tongue squamous cell carcinoma (OTSCC) has been considered a poor prognostic entity in terms of survival rate. The purpose of this study was to evaluate the incidence of locoregional recurrence and to identify significant risk factors for locoregional recurrence in early-stage OTSCC. We retrospectively reviewed the records of 58 patients who underwent radical surgery for T1-2N0 OTSCC. The local recurrence and regional recurrence rates were 10.3 % (6/58 patients) and 15. ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2013 - Springer Science+Business Media | Pathology & Oncology Research
Yuki Matsushita, Souichi Yanamoto, Hiroshi Takahashi, Shigeto Yamada, T. Naruse, Yuki Sakamoto, Hiroaki Ikeda, T Shiraishi, Shuichi Fujita, Takaya Ikeda, Izumi Asahina, Masahiro Umeda,
Abstract The risk factors for recurrence of head and neck cancer are classified as being of high or intermediate risk. Those of intermediate risk include multiple positive nodes without extracapsular nodal spread, perineural/vascular invasion, pT3/T4 primary tumours, and positive level IV/V nodes. However, little evidence is available to validate these intermediate risk factors. We analyzed perineural/vascular invasion in 89 patients who underwent radical surgery for oral tongue squamous cell carcinoma, ...
Tópico(s): Ear and Head Tumors
2015 - Elsevier BV | International Journal of Oral and Maxillofacial Surgery
Tomofumi Naruse, Souichi Yanamoto, Shin‐ichi Yamada, Hidenori Takahashi, Yuki Matsushita, Naomi Imayama, Hisazumi Ikeda, Takeshi Shiraishi, Shuichi Fujita, Tohru Ikeda, Izumi Asahina, Masahiro Umeda,
The aim of the present study was to elucidate the associations between the expression of the vascular endothelial growth factor-C (VEGF-C)/VEGF receptor-3 (VEGFR-3) axis and lymphangiogenesis, regional lymph node metastasis and clinicopathological factors in oral tongue squamous cell carcinoma (OTSCC) using immunohistochemistry. The expression of VEGF-C, VEGFR-3 and podoplanin was immunohistochemically evaluated in specimens obtained from 65 patients with OTSCC (T1-2, N0) who had undergone radical surgery ...
Tópico(s): Sympathectomy and Hyperhidrosis Treatments
2015 - Spandidos Publishing | Oncology Letters
Souichi Yanamoto, Shigeto Yamada, Hidenori Takahashi, Izumi Yoshitomi, Goro Kawasaki, H Ikeda, Tokutarou Minamizato, Takuya Shiraishi, Shuichi Fujita, Takaya Ikeda, Izumi Asahina, Masahiro Umeda,
Local recurrence of oral squamous cell carcinoma (OSCC) after primary surgery has been considered to be a poor prognostic entity in terms of survival rate. The purpose of this study is to evaluate the incidence of local recurrence and to identify significant risk factors for the local recurrence in OSCC. The authors retrospectively reviewed records for 187 patients who underwent radical surgery for OSCC. The local recurrence rate was 16.0% (30/187 patients) in this study. The survival rate of patients ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2012 - Elsevier BV | International Journal of Oral and Maxillofacial Surgery
Souichi Yanamoto, Shin‐ichi Yamada, Hidenori Takahashi, Tomofumi Naruse, Yuki Matsushita, Hisazumi Ikeda, Takeshi Shiraishi, Sachiko Seki, Shuichi Fujita, Tohru Ikeda, Izumi Asahina, Masahiro Umeda,
The efficacy of neoadjuvant chemotherapy (NAC) is controversial, and no report supports NAC with a high evidence level. Recently, we showed that a deep surgical margin was resected very close to the tumor site in many NAC-treated oral squamous cell carcinoma patients, suggesting that NAC may lead to local recurrence and poor outcomes. The purpose of this study was to evaluate the effect of NAC on tumor local recurrence using cancer stem cell marker immunohistochemistry. We retrospectively analyzed ...
Tópico(s): Cancer-related molecular mechanisms research
2014 - Spandidos Publishing | International Journal of Oncology
Ken‐ichi Takayama, Kuniko Horie‐Inoue, Shintaro Katayama, Takashi Suzuki, Shuichi Tsutsumi, Kazuhiro Ikeda, Tomohiko Urano, Tetsuya Fujimura, Kiyoshi Takagi, Satoru Takahashi, Yukio Homma, Yasuyoshi Ouchi, Hiroyuki Aburatani, Yoshihide Hayashizaki, Satoshi Inoue,
... for more papers by this author Shuichi Tsutsumi Shuichi Tsutsumi Genome Science Division, Research Center for Advanced Science and Technology (RCAST), University of Tokyo, Meguro-ku, Tokyo, Japan Search for more papers by this author Kazuhiro Ikeda Kazuhiro Ikeda Division of Gene Regulation and Signal ... for more papers by this author Shuichi Tsutsumi Shuichi Tsutsumi Genome Science Division, Research Center for Advanced Science and Technology (RCAST), University of Tokyo, Meguro-ku, Tokyo, Japan Search for more papers by this author Kazuhiro Ikeda Kazuhiro Ikeda Division of Gene Regulation and Signal ...
Tópico(s): RNA Research and Splicing
2013 - Springer Nature | The EMBO Journal
Shuichi Gomi, Daishiro Ikeda, H. Nakamura, HIROSHI NAGANAWA, Fumiyoshi Yamashita, Kunimoto Hotta, Shinichi Kondo, Yoshirō Okami, HAMAO UMEZAWA, Yöichi Iitaka,
Tópico(s): Synthesis and Biological Activity
1984 - Springer Nature | The Journal of Antibiotics
Masayuki NAKAMURA, Shizuo Sato, Tatsuo Ohya, Shuichi Suzuki, Sumio Ikeda,
All of the Salmonella enteritidis strains isolated from diseased animals (61 strains) and from beef (2 strains) in Japan and in West Germany (1 strain), except for 2 strains isolated from ducks, harbored either a 36-megadalton (Md) plasmid alone or in combination with several other plasmids of different sizes. It is likely that these 36-Md plasmids from various S. enteritidis strains were derived from the same origin because their plasmid DNAs showed the same cleavage patterns obtained with EcoRI, HindIII, ...
Tópico(s): Aquaculture disease management and microbiota
1985 - American Society for Microbiology | Infection and Immunity
Morihiko Nakamura, Shizuo Sato, Tatsuo Ohya, Shuichi Suzuki, Sumio Ikeda, Tetsuo Koeda,
We report the immunizing capacity of Salmonella enteritidis AL1192, a strain that has been cured of a 36-megadalton plasmid, to protect ddY mice against subsequent challenge with virulent salmonellas. This strain, which was given subcutaneously at a dose of 10(6) organisms, provided significant protection against oral, subcutaneous, or intraperitoneal challenge by virulent wild-type strains of not only S. enteritidis, but also S. dublin, S. naestved, and S. typhimurium.
Tópico(s): Vibrio bacteria research studies
1985 - American Society for Microbiology | Infection and Immunity
Shuichi Hiromasa, Takayuki Ikeda, Kouji Kubota, Nobutaka Hattori, Masao Nishimura, Yoshio Watanabe, Claudio Maldonado, Prasad R. Palakurthy, Joel Kupersmith,
Myotonic dystrophy is frequently associated with functional and anatomic derangements in the myocardium. Ten myotonic dystrophy patients (seven men and three women, ages ranging from 35 to 58 years) were evaluated with a 12-lead ECG, 24-hour Holter monitor recording, invasive electrophysiologic studies, and echocardiographic examination. Nine patients displayed abnormalities in the conduction system. ECG and Holter monitor abnormalities were first-degree atrioventricular block (n = 8), second-degree ...
Tópico(s): Neurology and Historical Studies
1987 - Elsevier BV | American Heart Journal
Masayuki NAKAMURA, Shizuo Sato, Tatsuo Ohya, Shuichi Suzuki, Sumio Ikeda,
Plasmid profiles were investigated in 65 isolates of Salmonella typhimurium derived from animal outbreaks during the period of 1978 through 1983 in Japan. Incidence of plasmids, drug-resistance, and conjugative R plasmids were extraordinarily high in these isolates. This high incidence reflects the prophylactic and therapeutic use of antibiotics. Most isolates from diseased animals, cohabiting animals, and each farm showed the same or similar plasmid patterns. However, there was a difference in ...
Tópico(s): Vibrio bacteria research studies
1986 - American Society for Microbiology | Journal of Clinical Microbiology
Shuichi Hiromasa, Takayuki Ikeda, Kouji Kubota, Shigeo Takada, Nobutaka Hattori, Masao Nishimura, Yoshio Watanabe,
Tópico(s): Neurological disorders and treatments
1986 - Elsevier BV | American Heart Journal
Ryszard Pluta, Shuichi Tomida, Junichi Ikeda, Thaddeus S. Nowak, I. Klatzo,
The time course of changes in cerebral intravascular volume was evaluated during 24 h following a series of three 5-min carotid artery occlusions spaced at 1-h intervals and compared with the changes occurring after single 5- or 15-min occlusions. Quantitative estimates of cerebral red cell volume, plasma volume, and total blood volume were obtained from the distribution spaces of 51 Cr-labeled erythrocytes and 125 I-albumin infused prior to killing at varied recirculation intervals. Significant ...
Tópico(s): Barrier Structure and Function Studies
1989 - SAGE Publishing | Journal of Cerebral Blood Flow & Metabolism
Shuichi Hiromasa, Takayuki Ikeda, Kouji Kubota, Nobutaka Hattori, Humberto Coto, Claudio Maldonado, Joel Kupersmith,
Myotonic Dystrophy type 1 (DM1) is a multisystemic disease, autosomal dominant, caused by a CTG repeat expansion in DMPK gene.We assessed the appropriateness of patient-specific induced pluripotent stem cell-derived cardiomyocytes (CMs) as a model to recapitulate some aspects of the pathogenetic mechanism involving cardiac manifestations in DM1 patients.Once obtained in vitro, CMs have been characterized for their morphology and their functionality. CMs DM1 show intranuclear foci and transcript markers ...
Tópico(s): Mitochondrial Function and Pathology
1988 - Elsevier BV | American Heart Journal
Shinichi Kondo, Shuichi Gomi, Daishiro Ikeda, MASA HAMADA, TOMIO TAKEUCHI, Hideaki Iwai, Junichi Seki, Hiroo Hoshino,
In vitro activities of benanomicins and their analogues against human immunodeficiency virus and fungi including Candida, Cryptococcus and Aspergillus, were examined. The free carboxyl group and at least one sugar moiety in the benanomicins were essential for their activities. Benanomicin A was most active and had low toxicity, and was selected as the best candidate for chemotherapy.
Tópico(s): Synthesis and Biological Evaluation
1991 - Springer Nature | The Journal of Antibiotics
Mitsuhiko Kawashima, Ryosuke Kohno, Kohei Nakachi, Teiji Nishio, Shuichi Mitsunaga, Masafumi Ikeda, Masaru Konishi, Shinichiro Takahashi, Naoto Gotohda, Satoko Arahira, Sadamoto Zenda, Takashi Ogino, Taira Kinoshitá,
To evaluate the safety and efficacy of radiotherapy using proton beam (PRT) for unresectable hepatocellular carcinoma.Sixty consecutive patients who underwent PRT between May 1999 and July 2007 were analyzed. There were 42 males and 18 females, with a median age of 70 years (48-92 years). All but 1 patient had a single lesion with a median diameter of 45 mm (20-100 mm). Total PRT dose/fractionation was 76-cobalt Gray equivalent (CGE)/20 fractions in 46 patients, 65 CGE/26 fractions in 11 patients, and ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2010 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Izumi Yoshitomi, Goro Kawasaki, Akio Mizuno, Masaharu Nishikido, Tomayoshi Hayashi, Shuichi Fujita, Tohru Ikeda,
Distant metastasis of malignant neoplasm to the oral soft tissue is extremely rare. We report a case of renal cell carcinoma (RCC) metastasizing to the tongue. A 47-year-old man visited our hospital with chief complaint of a lump on the middle third of the dorsum of his tongue and the lesion fell off from the tongue. Although histopathological diagnosis of the mass was granuloma teleangiectaticum, similar nodule reappeared in the same area 2 weeks later. The second lesion was composed of granuloma ...
Tópico(s): Tumors and Oncological Cases
2010 - Springer Science+Business Media | Medical Oncology
Munenori Numata, Tomohisa Fujisawa, Chun Li, Shuichi Haraguchi, Masato Ikeda, Kazuo Sakurai, Seiji Shinkai,
It has been demonstrated that a chiral, insulated poly(p-phenylene ethynylene) (PPE) nano-wire can be created by a polymer wrapping method utilizing natural β-1,3-glucan polysaccharide schizophyllan (SPG). Spectroscopic and microscopic measurements have revealed that PPE adopts a rigid conformation and exists as one piece in the helical hollow constructed by two SPG chains. Moreover, the inherent helical structure of SPG can induce the chiral twisting of the insulated PPE backbone. It is believed ...
Tópico(s): Luminescence and Fluorescent Materials
2007 - Taylor & Francis | Supramolecular chemistry
Sachiko Seki, Mutsunori Fujiwara, Masaaki Matsuura, Shuichi Fujita, Hisazumi Ikeda, Izumi Asahina, Tohru Ikeda,
Vascular invasion and lymph node metastasis have been used as histopathological prognosticators of cancers including oral squamous cell carcinoma (OSCC). In addition to metastatic potential via blood vessels, tumor-induced angiogenesis might also be associated with prognosis. However, the efficacy of combined evaluation of vascular invasion and angiogenesis-associated molecules for the prognosis of OSCC remains obscure. This is also the case in lymph node metastasis and lymphovasculogenesis-associated ...
Tópico(s): Head and Neck Cancer Studies
2011 - Elsevier BV | Oral Oncology