Phil Yates, Alyn Shipton, Catherine Philip, Oliver Holt Chief Sports Correspondent, Helen Studd, Robert Cole, Andy Dyson, Andrew Pierce, DJM, David Brown, James Moore, C. Brewer, Adam Sherwin Media Reporter, Frances Gibb Legal Editor, Simon Barnes, Carolyn Asome Fashion Writer, Peter Lansley, Rechel Campbell-Johnston, Mark Souster, Richard Hobson, Roy Porter, Jonathan Lennie, Ian Winrow, Michael Evans Defence Editor, Philip Howard, Bob Richardson, David Chater, Gabriel Hutton, Joanna Bale, Alexandra Frean Social Affairs Correspondent, Jack Malvorn, Richard Irving, Gabrielle Starkey, Carl Mortished, Elizabeth A. Powell, Kevin Eason, Alasdair MacKinnon, Martin Fletcher, Valerie Elliott Countryside Editor, Alfred Brendel, Libby Purves and Anne Ashworth, Jennai Cox Fitness Editor, Dominic Walsh, Steve Bird, Patrick Howarth, Judy Berwick, Adeline Iziren, Patience Wheatcrioft, Richard Ford Home Correspondent, Paul connolly, Stephen Farrell, Alan Hamilton, Edward Garden, Roland Watson, Charles Bremner, Deborah king, Roland Watson and Daniel McGrory, Nicholas Wapshott, Clive Mathieson Telecoms Correspondent, Anthony Bell, Mark Court, Justice Hardy, Paula Hawkins, Russell Kempson, David Rowan, David Rothwell, Richard Cork, Julian Corlett, Oliver Kay, Keith Barker-Main, Jim Bourlet, Rick Broadbent, Matt Dickinson Football Correspondent, Stephen Burgen, Karen Homer, Simon de Bruxelles, Brendan O'brien, Iain Finlavson, Clive Mathieson, Daniel McGrory Zahid Hussain and Roland Watson, Matt Dickinson, Christine Buckley Industrial Editor, Alastair Ross Goobey, Bronwen Maddox, Russell Hotten, Cathy Harris, Richard Owen, Helen Nugent, Christopher Martin-Jenkins Chief Cricket Correspondent, Erica Wagner, Tola Awogbamiye, Martin Thomas, Nick Hasell, Jane Twelves, David Hands Rugby Correspondent, Paul Simons, Martin Fletcher European Correspondent, John Gower-Jones, Mary Ann Sieghart, James Doran, Philip Webster Political Editor, Conor Dignam, Deborah King, George Caulkin, Russell Jenkins, Mark Court Health Industries Correspondent, Peter Riddell, Ben MacIntyre, John Goodbody Sports News Correspondent, Graham Anderson, Jane Adams, Enda Leahy, David Charter Chief Political Correspondent, David Sinclair, Simon Jenkins, Lea Paterson, Anne Ashworth Personal Finance Editor, Lewis Stuart, Martin Waller, Chris Ayres, Alan Coren, Nigel Hawkes Health Editor, Magnus Linklater and Angus MacLeod, John Chambers, Stephen Dalton, Richard Morrison, Paul Connolly, Martin Nelson, Alice Miles, Valerie Grove, Tom Baldwin Deputy Political Editor, John Cottrell, Alan Lee Racing Correspondent, Jan Raath, Richard Ford, Sally Patten Retail Correspondent, Patience Wheatcroft, Tim Bullamore,
... the War of the Consoles. DAvid Rowan meets shigeru Miyamoto Put to the test Dave Mirra 2 freestyle ...
2002 - Gale Group | TDA
Ryôhei Matuura, Hideo Kimizuka, Shigeru Miyamoto, Ryosuke Shimozawa,
Abstract The adsorption of the three alkyl sulfates, SDS, STS and SHS, at the solution-air interface has been measured directly by means of the radiotracer method. It has been proved that the surface adsorption increases with increase in the concentration and has a tendency to be saturated at concentrations near cmc for each detergent solution. The results have shown that the adsorption increases with increasing chain length. The Gibbs adsorption equation has been cheked and discussed.
Tópico(s): Water Quality Monitoring and Analysis
1958 - Oxford University Press | Bulletin of the Chemical Society of Japan
Abstract The surface tension of aqueous solutions of various metal dodecyl sulfates with divalent cations was measured at various temperatures with a Du Noüy’s tensiometer. The values of surface tension were observed to decrease steeply with the increase of their concentrations up to their cmc’s, which are all nearly equal to 1×10−3 mol./1. These values of cmc of the metal dodecyl sulfates with divalent cations were found to be practically independent of temperature and the kind of these cations. ...
Tópico(s): Adsorption, diffusion, and thermodynamic properties of materials
1960 - Oxford University Press | Bulletin of the Chemical Society of Japan
Abstract Calcium, strontium-, barium-, lead-, manganese-, magnesium-, cobalt- and copper dodecyl sulfates were synthesized and their compositions were determined from the results of their elementary analysis and metal content analysis. Further, the solubility of these metal dodecyl sulfates was measured at various temperatures. From these data, these metal dodecyl sulfates except barium salt were found to have the Krafft points, values of which were shown also.
Tópico(s): Inorganic and Organometallic Chemistry
1960 - Oxford University Press | Bulletin of the Chemical Society of Japan
Tatsuki Koike, Masato Yoshikawa, Haruhi Kamisaki Ando, William Farnaby, Toshiya Nishi, Etsurou Watanabe, Jason K. Yano, Maki Miyamoto, Shigeru Kondo, Tsuyoshi Ishii, Takanobu Kuroita,
Cholesterol 24-hydroxylase (CH24H, CYP46A1), a brain-specific cytochrome P450 (CYP) family enzyme, plays a role in the homeostasis of brain cholesterol by converting cholesterol to 24S-hydroxycholesterol (24HC). Despite a wide range of potential of CH24H as a drug target, no potent and selective inhibitors have been identified. Here, we report on the structure-based drug design (SBDD) of novel 4-arylpyridine derivatives based on the X-ray co-crystal structure of hit derivative 1b. Optimization of 4- ...
Tópico(s): Hormonal Regulation and Hypertension
2021 - American Chemical Society | Journal of Medicinal Chemistry
Masaki Miyamoto, Shigeru Sasakawa, Tastushi Ozawa, Haruma Kawaguchi, Yasuji Ohtsuka,
Latex particles with highly negative or positive charges shortened the clotting time of whole blood and platelet-rich plasma and activated platelet factor 3. Platelet-poor plasma was clotted by the particles with a highly negative charge, but not by those with a positive charge, except hydrophobic particles. Blood coagulation by positively-charged particles was attributed to platelet activation. An enhancement of blood coagulation was also observed in the presence of erythrocytes, leucocytes, their ...
Tópico(s): Microplastics and Plastic Pollution
1990 - Elsevier BV | Biomaterials
Bao-Liang Lin, Y. Iwata, Naohiko Miyamoto, Shigeru Hayashi,
The "three-contrasts method" of ultrasonography is designed to monitor transcervical operations for submucous uterine myomas and uterine septa when a pediatric urologic resectoscope is used. This monitoring method has proved more effective than concomitant laparoscopy. The pediatric resectoscope can also be used efficiently for diagnostic and therapeutic purposes without dilating the cervical canal.
Tópico(s): Hernia repair and management
1987 - Elsevier BV | American Journal of Obstetrics and Gynecology
Takeshi Miyamoto, Shigeru Takagi, Tai Hasegawa, Seizi Tsuzuki, Eitaro Takahashi, Kojiro Okude, Itsuki Banno, Yukiyoshi Sasaki,
Abstract The synthesis and properties of new, bulky atropisomeric porphyrins are described. Four atropisomers of 5,10,15,20-tetrakis(3,5-di-t-butyl-2-nitrophenyl)porphyrins has been easily separated and purified by column chromatography. The isomers all have different thermal stabilities toward atropisomerization. Below 60 °C, however, they have rather high conformational stabilities, and an iron(III) or manganese(III) ion has been incorporated into each isomer, with a retention of the ligand conformation. ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
1987 - Oxford University Press | Bulletin of the Chemical Society of Japan
Haruma Kawaguchi, Naoko Koiwai, Yasuji Ohtsuka, Masaki Miyamoto, Shigeru Sasakawa,
A series of latex particles, having different sizes and surface structures, were prepared and the dependence of phagocytosis of latex particles by leucocytes on the particle size and surface potential was investigated by measuring the oxygen consumption of leucocytes. Most of the phagocytic behaviour in the initial stages can be explained by susceptibility of particles to heterocoagulation i.e. attachment of small particles (latex particles) onto large particles (leucocytes) by the colloidal attractive ...
Tópico(s): Platelet Disorders and Treatments
1986 - Elsevier BV | Biomaterials
Masaki Miyamoto, Shigeru Sasakawa, Tatsushi Ozawa, Haruma Kawaguchi, Yasuji Ohtsuka,
Latex particles induced platelet aggregation associated with the release of ATP from the platelets. The smaller the diameter of particles having the same surface structure, the greater numbers or greater total surface area of particles were required for both reactions. The higher Hydrophobie and higher negatively charged particles, having a diameter of about 0.3 urn, induced platelet aggregation most easily. Hydrophilic particles without high negative surface potential activated platelets only a ...
Tópico(s): Proteins in Food Systems
1989 - Elsevier BV | Biomaterials
Masaki Miyamoto, Shigeru Sasakawa, Yoshihide Ishikawa, Atsuko Ogawa, Takao Nishimura, Toru Kuroda,
Abstract. We developed a new filter, ‘Sepacell‐PL’, consisting of a blood administraiton set for the preparation of leukocyte‐poor platelet concentrates at the patient's bedside. This filter is packed with 1.8 μm polyester fibers coated with a new polymer, and has a volume of 14 ml. Sepacell‐PL removed more than 99% of the leukocytes while approximately 93% of platelets were recovered from 10 units of platelet concentrates which contained 5 times 10 8 leukocytes and 3 times 10 11 platelets. The functions ...
Tópico(s): Platelet Disorders and Treatments
1989 - Wiley | Vox Sanguinis
Naoki Miura, Motoaki Sugiura, Makoto Takahashi, Yuko Sassa, Atsushi Miyamoto, Shigeru Sato, Kaoru Horie, Katsuki Nakamura, Ryuta Kawashima,
Motion smoothness is critical in transmitting implicit information of body action, such as aesthetic qualities in dance performances. We expected that the perception of motion smoothness would be characterized by great intersubject variability deriving from differences in personal backgrounds and attitudes toward expressive body actions. We used functional magnetic resonance imaging and a humanoid robot to investigate the effects of the motion smoothness of expressive body actions and the intersubject ...
Tópico(s): Visual perception and processing mechanisms
2009 - Taylor & Francis | Social Neuroscience
Akira Tamura, Yukie Goto, Kumie Miyamoto, Shigeru Naono, Yoshiyuki Kawano, Munenori Kotoku, Toru Watanabe, Jun‐ichi Kadota,
We sought to clarify whether a single-bolus intravenous administration of sodium bicarbonate in addition to hydration with sodium chloride prevents contrast-induced nephropathy (CIN). One hundred forty-four patients with mild renal insufficiency (serum creatinine >1.1 to 25% or >0.5 mg/dl in serum creatinine within 3 days after the procedure. Incidence of the primary end point was lower in group A than in group B (1.4% vs 12.5%, p = 0.017). Incidence of adverse clinical events (acute pulmonary edema, acute ...
Tópico(s): Trauma, Hemostasis, Coagulopathy, Resuscitation
2009 - Elsevier BV | The American Journal of Cardiology
Tatsuya Yokoyama, Hiromi Oono, Atsushi Miyamoto, Shigeru Ishiguro, Akira Nishio,
Magnesium deficiency has been shown to increase nitric oxide (NO) levels in plasma and to aggravate endotoxin lethality. The present study was performed to examine the effects of magnesium (Mg(2+))-deficient culture medium, with and without endotoxin (LPS), on NO release and inducible NOS (iNOS) mRNA levels in alveolar macrophages isolated from rats. Decreasing the Mg(2+) concentration in the culture medium from 0.39 mM (normal-Mg(2+) medium) to 0.021 mM (Mg(2+)-deficient medium) increased NO release ...
Tópico(s): Aluminum toxicity and tolerance in plants and animals
2003 - Elsevier BV | Life Sciences
Kiyoko T. Miyamoto, Shigeru Kitani, Mamoru Komatsu, Haruo Ikeda, Takuya Nihira,
The γ-butyrolactone autoregulator receptor has been shown to control secondary metabolism and/or morphological differentiation across many Streptomyces species. Streptomyces avermitilis produces an important anthelmintic agent (avermectin) and two further polyketide antibiotics, filipin and oligomycin. Genomic analysis of S. avermitilis revealed that this micro-organism has the clustered putative autoregulator receptor genes distant from the antibiotic biosynthetic gene clusters. Here, we describe ...
Tópico(s): Antibiotic Resistance in Bacteria
2011 - Microbiology Society | Microbiology
Miho Uchida, Satoshi Takamatsu, Shiho Arima, Kiyoko T. Miyamoto, Shigeru Kitani, Takuya Nihira, Haruo Ikeda, Tohru Nagamitsu,
The first total synthesis of extracellular factor, "Avenolide", in Streptomyces avermitilis has been achieved using a convergent approach. The stereogenic centers in two key segments were installed using Sharpless epoxidation and dihydroxylation. This synthetic study allowed the determination of the absolute configuration of avenolide as 4S,10R, and yielded important information on its structure-activity relationship.
Tópico(s): Asymmetric Synthesis and Catalysis
2011 - Springer Nature | The Journal of Antibiotics
Toshisuke Sakaki, Masao Tominaga, Kazunori Miyamoto, Shigeru Tsunoda, Yoshio Hiasa,
Although multiple cerebral aneurysms ae well recognized, a new aneurysm has only rarely been documented after successful treatment for an aneurysm elsewhere. In our consecutive series of 986 patients with intracranial saccular arterial aneurysm collected from 1975 to 1990, nine patients who had previously unverified (hence, de novo) intracranial aneurysms and ruptures at intervals of 4 to 7.5 years after clipping of an initial aneurysm are presented here. All nine had undergone successful treatment ...
Tópico(s): Moyamoya disease diagnosis and treatment
1993 - Lippincott Williams & Wilkins | Neurosurgery
Narihisa Matsumoto, Masato Okada, Yasuko Sugase-Miyamoto, Shigeru Yamane,
Tópico(s): Neural Networks and Applications
2005 - Springer Science+Business Media | Journal of Computational Neuroscience
Katsumi Shibata, Tsutomu Fukuwatari, Mari Ohta, Hidemi Okamoto, Toshiaki Watanabe, Tooru Fukui, Mamoru Nishimuta, Masayuki Totani, Mieko Kimura, Nobuko Ohishi, Mieko Nakashima, Fumio Watanabe, Emi Miyamoto, Shigeru Shigeoka, T Takeda, Megumi Murakami, Hiroshi Ihara, Naotaka Hashizume,
We investigated the levels of water-soluble vitamins except for vitamin B6 in the blood and urine of Japanese college male (n=10) and female (n=10) students. They consumed for 7 d a semi-purified diet based on Japanese Dietary Reference Intakes to assess the Recommended Dietary Allowances (RDA) for water-soluble vitamins and to present some new normal values for blood and urine levels of water-soluble vitamins in Japanese. The blood and the 24-h urine samples were collected on the last day of the experiment ...
Tópico(s): Alcoholism and Thiamine Deficiency
2005 - Center for Academic Publications Japan | Journal of Nutritional Science and Vitaminology
Yusuke Tsukatani, Ryo Miyamoto, Shigeru Itoh, Hirozo Oh‐oka,
The PscD subunit in the homodimeric "type I" photosynthetic reaction center (RC) complex of the green sulfur bacterium Chlorobium tepidum was disrupted by insertional mutagenesis of its relevant pscD gene. This is the first report on the use of the direct mutagenic approach into the RC-related genes in green sulfur bacteria. The RC complex of C. tepidum is supposed to form a homodimer of two identical PscA subunits together with three other subunits: PscB (FA/FB-containing protein), PscC (cytochrome ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2004 - Elsevier BV | Journal of Biological Chemistry
Narihisa Matsumoto, Masato Okada, Yasuko Sugase-Miyamoto, Shigeru Yamane, Kenji Kawano,
Neurons in the inferior temporal (IT) cortex of monkeys respond selectively to complex visual stimuli, such as faces. Single neurons in the IT cortex encode different kinds of information about visual stimuli in their temporal firing patterns. To understand the temporal aspects of the information encoded at a population level in the IT cortex, we applied principal component analysis (PCA) to the responses of a population of neurons. The responses of each neuron were recorded while visual stimuli that ...
Tópico(s): Neural dynamics and brain function
2004 - Oxford University Press | Cerebral Cortex
Reiko Itoh, Shoko Kawamoto, Yasuhide Miyamoto, Shigeru Kinoshita, Kousaku Okubo,
AbstractPurpose. Transparency of the cornea is maintained through the activity of secretory mechanisms in the epithelium and endothelium, which offset the tendency of the stroma to imbibe fluid and swell. These secretory mechanisms establish osmotic gradients thereby providing the osmotic driving forces for coupled fluid transport from the stroma into both the tears and the anterior chamber. To further characterize the mechanism of epithelial Cl secretion, we cloned a cDNA encoding a Ca 2+ -dependent ...
Tópico(s): Connexins and lens biology
2000 - Taylor & Francis | Current Eye Research
Masaru Ishihara, Masahiro Itoh, Kensaku Miyamoto, Shigeru Suna, Yoshiki Takeuchi, Ikumasa Takenaka, Fumihiko Jitsunari,
Phthalate esters, now regarded as endocrine disruptors, are widely used in the plastics industry. In particular, di‐(2‐ethylhexyl) phthalate (DEHP) is produced in large quantities, and is used in blood storage bags, catheters and haemodialysis instruments. Previous studies have demonstrated that treatment of rats with DEHP induces testicular atrophy with liver enlargement, although the precise nature and mechanism of the action of DEHP on these organs remains unclear. In the present study, we produced ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2000 - Wiley | Andrology
Jiro Deguchi, Masaki Miyamoto, Shigeru Okada,
Ferric nitrilotriacetate (Fe-NTA), an iron chelate, induces necrosis of renal proximal convoluted tubules as a consequence of lipid peroxidation, and a high incidence of renal cell carcinoma (RCC) is also observed in rats and mice. The incidence of RCC and the extent of lipid peroxidation are greater in males than females. In the present study, the effects of castration or ovariectomy, and sex hormone treatment on Fe-NTA-induced renal carcinogenesis in rats were examined. Male and female Wistar rats ...
Tópico(s): Glutathione Transferases and Polymorphisms
1995 - Oxford University Press | Japanese Journal of Cancer Research
Taro Yamamoto, Kaoru Terada, Noriyuki Nishida, R Moriuchi, Susumu Shirabe, Tatsufumi Nakamura, Y Tsuji, Tsutomu Miyamoto, Shigeru Katamine,
Human T-cell lymphotropic virus type 1 (HTLV-1) is known to be transmitted vertically through breastfeeding and horizontally by blood transfusion and sexual contact. Our intervention study has suggested the presence of additional alternative maternal transmission pathways. To explore the possibility of transmission through saliva, we used PCR to quantify the HTLV-1 provirus in saliva samples from 18 carrier mothers and 10 patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. The ...
Tópico(s): Vector-Borne Animal Diseases
1995 - American Society for Microbiology | Journal of Clinical Microbiology
Kenji Miyamoto, Shigeru Kuwano, Jun Terada, Akihiro Otaka,
We analyze the mobile fronthaul (MFH) bandwidth and the wireless transmission performance in the split-PHY processing (SPP) architecture, which redefines the functional split of centralized/cloud RAN (C-RAN) while preserving high wireless coordinated multi-point (CoMP) transmission/reception performance. The SPP architecture splits the base stations (BS) functions between wireless channel coding/decoding and wireless modulation/demodulation, and employs its own CoMP joint transmission and reception schemes. ...
Tópico(s): Satellite Communication Systems
2016 - Optica Publishing Group | Optics Express
Kenji Miyamoto, Shigeru Kuwano, Tatsuya Shimizu, Jun Terada, Akihiro Otaka,
We experimentally evaluate the mobile fronthaul (MFH) optical bandwidth and wireless coordinated multipoint (CoMP) transmission and reception performance in Ethernet-based MFH with our proposed split-physical (PHY) processing (SPP). To reduce the MFH optical bandwidth, SPP redefines the base station (BS) functional split between the baseband unit (BBU) and the remote radio head (RRH) in a centralized/cloud radio access network (C-RAN) with a common public radio interface. The functional split point of SPP ...
Tópico(s): Telecommunications and Broadcasting Technologies
2016 - | Journal of Optical Communications and Networking
Yasuko Sugase-Miyamoto, Shigeru Yamane, Shoogo Ueno, Kenji Kawano,
Tópico(s): Visual perception and processing mechanisms
1999 - Nature Portfolio | Nature
Atsushi Miyamoto, Shigeru Ishiguro, Akira Nishio,
The aim of the present study was to characterize the subtypes of bradykinin (BK) receptors that evoke the relaxation and contraction induced by BK and to identify the main contracting and relaxing factors in isolated porcine basilar artery by measuring changes in isometric tension and a thromboxane (TX) metabolite. Endothelial denudation completely abolished both responses. [Thi 5,8 , D ‐Phe 7 ]‐BK (a B 2 ‐receptor antagonist) inhibited the BK‐induced relaxation and contraction, whereas des‐Arg 9 , [Leu 8 ]‐BK ( ...
Tópico(s): Protease and Inhibitor Mechanisms
1999 - Wiley | British Journal of Pharmacology
Akira Yokoyama, Nobuyuki Kakiuchi, Tetsuichi Yoshizato, Yasuhito Nannya, Hiromichi Suzuki, Yasuhide Takeuchi, Yusuke Shiozawa, Yusuke Sato, Kosuke Aoki, Soo Ki Kim, Yoichi Fujii, Kenichi Yoshida, Keisuke Kataoka, Masahiro Nakagawa, Yoshikage Inoue, Tomonori Hirano, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Yoshitaka Nishikawa, Yusuke Amanuma, Shinya Ohashi, Ikuo Aoyama, Takahiro Horimatsu, Shin’ichi Miyamoto, Shigeru Tsunoda, Yoshiharu Sakai, Maiko Narahara, J.B. Brown, Yoshitaka Sato, Genta Sawada, Koshi Mimori, Sachiko Minamiguchi, Hironori Haga, Hiroshi Seno, Satoru Miyano, Hideki Makishima, Manabu Muto, Seishi Ogawa,
Clonal expansion in aged normal tissues has been implicated in the development of cancer. However, the chronology and risk dependence of the expansion are poorly understood. Here we intensively sequence 682 micro-scale oesophageal samples and show, in physiologically normal oesophageal epithelia, the progressive age-related expansion of clones that carry mutations in driver genes (predominantly NOTCH1), which is substantially accelerated by alcohol consumption and by smoking. Driver-mutated clones ...
Tópico(s): Genetic factors in colorectal cancer
2018 - Nature Portfolio | Nature