Akira Imamura, Yoshiro Morimoto, Shinji Ono, Naohiro Kurotaki, Shinji Kanegae, Naoki Yamamoto, Hirohisa Kinoshita, Takahiro Tsujita, Yuji Okazaki, Hiroki Ozawa,
Twin studies of psychiatric disorders such as schizophrenia and autism spectrum disorder have employed epidemiological approaches that determine heritability by comparing the concordance rate between monozygotic twins (MZs) and dizygotic twins. The basis for these studies is that MZs share 100% of their genetic information. Recently, biological studies based on molecular methods are now being increasingly applied to examine the differences between MZs discordance for psychiatric disorders to unravel ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2020 - Springer Science+Business Media | Journal of Neural Transmission
Takeshi Nakano, Shinji Ono, Junji Yamaguchi, Ryu Sugimoto, Naohiro Yamaguchi, Yoshiro Morimoto, Tatsuya Kubo, Hiroki Ozawa, Naohiro Kurotaki,
... with Huntington’s disease Author(s) Nakano, Takeshi; Ono, Shinji; Yamaguchi, Junji; Sugimoto, Ryu; Yamaguchi, Naohiro; Morimoto, Yoshiro; ...
Tópico(s): Obsessive-Compulsive Spectrum Disorders
2012 - Springer Science+Business Media | Journal of Neurology
Nagara Tamaki, Yasuhiro Magata, Norio Takahashi, Masahide Kawamoto, Tatsuo Torizuka, Yoshiharu Yonekura, Eiji Tadamura, Kazumi Okuda, Shinji Ono, Ryuji Nohara, Hirofumi Kambara, Junji Konishi,
Tópico(s): Cardiovascular Function and Risk Factors
1993 - Springer Science+Business Media | European Journal of Nuclear Medicine
Nagara Tamaki, Yasuhiro Magata, Norio Takahashi, Masahide Kawamoto, Tatsuo Torizuka, Yoshiharu Yonekura, Sadahiko Nishizawa, Norihiro Sadato, Eiji Tadamura, Shinji Ono, Ryuji Nohara, Hirofumi Kambara, Junji Konishi,
Tópico(s): Medical Imaging Techniques and Applications
1992 - Springer Nature | Annals of Nuclear Medicine
Shinji Ono, Ryuji Nohara, Hirofumi Kambara, K Okuda, C Kawai,
Several authors have reported cases in which 201Tl scintigraphy demonstrated perfusion abnormality in the septum of patients with left bundle branch block (LBBB) and normal coronary arteriogram. The mechanism of this abnormality, however, remains to be clarified.To determine whether LBBB itself induces abnormal myocardial perfusion and ischemia and to elucidate its mechanism, we used an in vivo animal model. LBBB was induced by right ventricular pacing in 17 open-chest dogs. We examined myocardial ...
Tópico(s): Cardiovascular Function and Risk Factors
1992 - Lippincott Williams & Wilkins | Circulation
Sumio Ozeki, Chihiro Wakai, Shinji Ono,
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIs a magnetic effect on water adsorption possible?Sumio Ozeki, Chihiro Wakai, and Shinji OnoCite this: J. Phys. Chem. 1991, 95, 26, 10557–10559Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/j100179a012https://doi.org/10.1021/j100179a012research-articleACS PublicationsRequest reuse permissionsArticle Views304Altmetric-Citations24LEARN ABOUT THESE METRICSArticle ...
Tópico(s): Magnetic and Electromagnetic Effects
1991 - American Chemical Society | The Journal of Physical Chemistry
Arshad M. Khanani, Aachal Kotecha, Andrew Chang, Shih‐Jen Chen, Youxin Chen, Robyn H. Guymer, Jeffrey S. Heier, Frank G. Holz, Tomohiro Iida, Jane A. Ives, Jennifer I. Lim, Hugh Lin, Stephan Michels, Carlos Quezada-Ruiz, Ursula Schmidt‐Erfurth, David G. Silverman, Rishi P. Singh, Balakumar Swaminathan, Jeffrey R. Willis, Ramin Tadayoni, Ashkan M. Abbey, Elmira Abdulaeva, Prema Abraham, Alfredo Adán, Hansjürgen Agostini, Arturo Alezzandrini, Virgil Alfaro, Arghavan Almony, Lebriz Altay, Payam Amini, Andrew N. Antoszyk, Etelka Aradi, Luís Arias, Jennifer Arnold, Riaz Asaria, Sergei Astakhov, Yury S. Astakhov, Carl C. Awh, Chandra Balaratnasingam, Sanjiv Banerjee, Caroline R. Baumal, Matthias Becker, Rubens Belfort, Galina Bratko, William Bridges, Jamin S. Brown, David M. Brown, M V Budzinskaya, S. Buffet, Stuart C Burgess, Ik Soo Byon, Carlo Cagini, Jorge I. Calzada, Stone Cameron, Peter A. Campochiaro, John S. Carlson, Ângela Carneiro, Clement Chan, Emmanuel Chang, Andrew Chang, Daniel L. Chao, Nauman Chaudhry, Caroline Chee, Andrew Cheek, Shih‐Jen Chen, San‐Ni Chen, Chui Ming Gemmy Cheung, Saradha Chexal, Mark Chittum, David R. Chow, Abosede Cole, B. Connolly, Pierre Loïc Cornut, Stephen Couvillion, Carl J. Danzig, Vesselin Daskalov, Amr Dessouki, François Devin, Michael Dollin, Rosa Dolz, Louise Downey, Richard F. Dreyer, Pravin U. Dugel, David Eichenbaum, Bora Eldem, Robert E. Engstrom, Joan Josep Escobar, Nicole Eter, David Faber, Naomi S. Falk, Leonard Feiner, Alvaro Fernandez Vega, Philip J. Ferrone, Marta S. Figueroa, Howard F. Fine, Mitchell S. Fineman, Gregory M. Fox, Catherine Français, Pablo Moreno Franco, Samantha Fraser‐Bell, Nicholas Fung, Federico Furno Sola, Richard Gale, Alfredo García‐Layana, Julie Gasperini, Maciej Gawęcki, Faruque Ghanchi, Manjot K. Gill, Michel Giunta, David L. Glaser, Michaella Goldstein, Francisco Gomez Ulla, Fumi Gomi, Víctor H. González, J. L. GRAFF, Sunil Gupta, Rainer Guthoff, Robyn H. Guymer, Anton Haas, Robert L. Hampton, Katja Hatz, Ken Hayashi, Jeffrey S. Heier, Ewa Herba, Vrinda Hershberger, Patrick Higgins, Nancy M. Holekamp, Shigeru Honda, J. G. Howard, Allen Hu, Stephen Huddleston, Tomohiro Iida, Hiroko Imaizumi, Yasuo Ito, Yasuki Ito, Sujit Itty, Golnaz Javey, Cameron Javid, T. Kaga, J Kałuzný, Se Woong Kang, Kapil Kapoor, Levent Karabaş, Tsutomu Kawasaki, Patrick Kelty, Ágnes Kerényi, Arshad M. Khanani, Ramin Khoramnia, Rahul N. Khurana, Kazuhiro Kimura, Kendra Klein-Mascia, Namie Kobayashi, Laurent Kodjikian, Hideki Koizumi, Gregg T. Kokame, Alexey N. Kulikov, Henry Kwong, Robert Kwun, Timothy Y. Y. Lai, Chi‐Chun Lai, Laurent Lalonde, Paolo Lanzetta, Michael Larsen, Adrian Lavina, Won Ki Lee, Ji Eun Lee, Seong Lee, Jaime Levy, Lucas Lindsell, Mimi Liu, Nikolas London, Andrew Lotery, David Lozano Rechy, Alan Luckie, David Maberley, Takatoshi Maeno, Sajjad Mahmood, Fuad Makkouk, Dennis M. Marcus, Alan Margherio, Hélène Masse, Hisashi Matsubara, Raj K. Maturi, Sonia Mehta, Geeta Menon, Jale Menteş, Mark Michels, Yoshinori Mitamura, Paul Mitchell, Quresh Mohamed, Jordi Monés, Rodrigo Montemayor Lobo, Javier Montero, Jeffrey S. Moore, Ryusaburo Mori, Haia Morori-Katz, Rajarshi Mukherjee, Toshinori Murata, Maria Muzyka−Woźniak, Marco Nardi, Niro Narendran, Massimo Nicolò, Jared S. Nielsen, Tetsuya Nishimura, Kousuke Noda, Anna Nowińska, Hideyasu Oh, Matthew Ohr, Annabelle A. Okada, Piotr Oleksy, Shinji Ono, Şengül Özdek, Banu Öztürk, Luís E. Pablo, Kyu Hyung Park, D. Wilk Parke, Maria Cristina Parravano, Praveen J. Patel, Apurva R. Patel, Sunil Patel, Sugat Patel, Daniel Pauleikhoff, Ian Pearce, Joel Pearlman, Iva Petkova, Dante J. Pieramici, N. A. Pozdeyevа, Jawad Qureshi, Dorota Raczyńska, Juan Ramirez Estudillo, Rajiv Rathod, Hessam Razavi, Carl D. Regillo, Gayatri Reilly, Federico Ricci, Ryan Rich, Bożena Romanowska‐Dixon, Irit Rosenblatt, José M. Ruiz‐Moreno, Stefan Sacu, Habiba Saedon, Usman Saeed, Min Sagong, Taiji Sakamoto, Sukhpal S. Sandhu, Laura Sararols, Mario Saravia, Ramin Schadlu, Patricio G. Schlottmann, Tetsuju Sekiryu, András Seres, Figen Şermet, Sumit P. Shah, Rohan Shah, Ankur Shah, Tom Sheidow, Veeral Sheth, Chieko Shiragami, Bartosz L. Sikorski, Rufino Silva, Lawrence J. Singerman, Robert A. Sisk, Torben Lykke Sørensen, Eric H. Souied, David-J. Spinak, Giovanni Staurenghi, Robert L. Steinmetz, Glenn Stoller, Robert Stoltz, Eric Suan, Iván J. Suñer, Suzanne Yzer, Ramin Tadayoni, Kanji Takahashi, Kei Takayama, Alexandre Chater Taleb, James Talks, Hiroko Terasaki, John F. Thompson, Edit Tóth‐Molnár, Khoi Tran, Raman Tuli, Eduardo Uchiyama, Attila Vajas, Janneke Van Lith-Verhoeven, Balázs Varsányi, Francesco Viola, Gianni Virgili, Gábor Vogt, Michael Völker, David Warrow, Pamela Weber, John A. Wells, Sanjeewa Wickremasinghe, Mark R. Wieland, Geoff Williams,
PurposeTo evaluate 2-year efficacy, durability, and safety of the bispecific antibody faricimab, which inhibits both angiopoietin-2 and VEGF-A.DesignTENAYA (ClinicalTrials.gov identifier, NCT03823287) and LUCERNE (ClinicalTrials.gov identifier, NCT03823300) were identically designed, randomized, double-masked, active comparator-controlled phase 3 noninferiority trials.ParticipantsTreatment-naive patients with neovascular age-related macular degeneration (nAMD) 50 years of age or older.MethodsPatients ...
Elsevier BV
Jeffrey S. Heier, Arshad M. Khanani, Carlos Quezada-Ruiz, Karen Basu, Philip J. Ferrone, Christopher Brittain, Marta S. Figueroa, Hugh Lin, Frank G. Holz, Vaibhavi Patel, Timothy Y. Y. Lai, David G. Silverman, Carl D. Regillo, Balakumar Swaminathan, Francesco Viola, Chui Ming Gemmy Cheung, Tien Yin Wong, Ashkan M. Abbey, Elmira Abdulaeva, Prema Abraham, Alfredo Adán, Hansjürgen Agostini, Arturo Alezzandrini, Virgil Alfaro, Arghavan Almony, Lebriz Altay, Payam Amini, Andrew N. Antoszyk, Etelka Aradi, Luís Arias, Jennifer Arnold, Riaz Asaria, Sergei Astakhov, Yury S. Astakhov, Carl C. Awh, Chandra Balaratnasingam, Sanjiv Banerjee, Caroline R. Baumal, Matthias Becker, Rubens Belfort, Galina Bratko, William Jr. Z Bridges, Jamin S. Brown, David M. Brown, M V Budzinskaya, S. Buffet, Stuart C Burgess, Ik Soo Byon, Carlo Cagini, Jorge I. Calzada, Stone Cameron, Peter A. Campochiaro, John S. Carlson, Ângela Carneiro, Clement K. Chan, Emmanuel Chang, Andrew Chang, Daniel L. Chao, Nauman Chaudhry, Caroline Chee, Andrew Cheek, Shih‐Jen Chen, San‐Ni Chen, Chui Ming Gemmy Cheung, Saradha Chexal, Mark Chittum, David R. Chow, Abosede Cole, B. Connolly, Pierre Loïc Cornut, Stephen Couvillion, Carl J. Danzig, Vesselin Daskalov, Amr Dessouki, François Devin, Michael Dollin, Rosa Dolz, Louise Downey, Richard F. Dreyer, Pravin U. Dugel, David Eichenbaum, Bora Eldem, Robert E. Engstrom, Joan Josep Escobar, Nicole Eter, David Faber, Naomi S. Falk, Leonard Feiner, Alvaro Fernandez Vega, Philip J. Ferrone, Marta S. Figueroa, Howard F. Fine, Mitchell S. Fineman, Gregory M. Fox, Catherine Français, Pablo Moreno Franco, Samantha Fraser‐Bell, Nicholas Fung, Federico Furno Sola, Richard Gale, Alfredo García‐Layana, Alfredo García‐Layana, Julie Gasperini, Maciej Gawęcki, Faruque Ghanchi, Manjot K. Gill, Michel Giunta, David L. Glaser, Michaella Goldstein, Francisco Gomez Ulla, Fumi Gomi, Víctor H. González, J. L. GRAFF, Sunil Gupta, Rainer Guthoff, Robyn H. Guymer, Anton Haas, Robert L. Hampton, Katja Hatz, Ken Hayashi, Jeffrey S. Heier, Ewa Herba, Vrinda Hershberger, Patrick Higgins, Nancy M. Holekamp, Shigeru Honda, J. G. Howard, Allen Hu, Stephen J. Huddleston, Tomohiro Iida, Hiroko Imaizumi, Yasuo Ito, Yasuki Ito, Sujit Itty, Golnaz Javey, Cameron Javid, T. Kaga, J Kałuzný, Se Woong Kang, Kapil Kapoor, Levent Karabaş, Tsutomu Kawasaki, Patrick Kelty, Ágnes Kerényi, Arshad M. Khanani, Ramin Khoramnia, Rahul N. Khurana, Kazuhiro Kimura, Kendra Klein-Mascia, Namie Kobayashi, Laurent Kodjikian, Hideki Koizumi, Gregg T. Kokame, Alexey N. Kulikov, Henry Kwong, Robert Kwun, Timothy Y. Y. Lai, Chi‐Chun Lai, Laurent Lalonde, Paolo Lanzetta, Michael Larsen, Adrian Lavina, Won Ki Lee, Ji Eun Lee, Seong Lee, Jaime Levy, Lucas Lindsell, Mimi Liu, Nikolas London, Andrew Lotery, David Lozano Rechy, Alan Luckie, David Maberley, Takatoshi Maeno, Sajjad Mahmood, Fuad Makkouk, Dennis M. Marcus, Alan Margherio, Hélène Masse, Hisashi Matsubara, Raj K. Maturi, Sonia Mehta, Geeta Menon, Jale Menteş, Mark Michels, Yoshinori Mitamura, Paul Mitchell, Quresh Mohamed, Jordi Monés, Rodrigo Montemayor Lobo, Javier Montero, Jeffrey S. Moore, Ryusaburo Mori, Haia Morori-Katz, Rajarshi Mukherjee, Toshinori Murata, Maria Muzyka−Woźniak, Marco Nardi, Niro Narendran, Massimo Nicolò, Jared S. Nielsen, Tetsuya Nishimura, Kousuke Noda, Anna Nowińska, Hideyasu Oh, Matthew Ohr, Annabelle A. Okada, Piotr Oleksy, Shinji Ono, Şengül Özdek, Banu Öztürk, Luís E. Pablo, Kyu Hyung Park, David W Parke, Maria Cristina Parravano, Praveen J. Patel, Apurva Patel, Sunil Patel, Sugat Patel, Daniel Pauleikhoff, Ian Pearce, Joel Pearlman, Iva Petkova, Dante J. Pieramici, N. A. Pozdeyevа, Jawad Qureshi, Dorota Raczyńska, Juan Ramirez Estudillo, Rajiv Rathod, Hessam Razavi, Carl D. Regillo, Gayatri Reilly, Federico Ricci, Ryan Rich, Bożena Romanowska‐Dixon, Irit Rosenblatt, José M. Ruiz‐Moreno, Stefan Sacu, Habiba Saedon, Usman Saeed, Min Sagong, Taiji Sakamoto, Sukhpal S. Sandhu, Laura Sararols, Mario Saravia, Ramin Schadlu, Patricio G. Schlottmann, Tetsuju Sekiryu, András Seres, Figen Şermet, Sumit P. Shah, Rohan Shah, Ankur Shah, Tom Sheidow, Veeral Sheth, Chieko Shiragami, Bartosz L. Sikorski, Rufino Silva, Lawrence J. Singerman, Robert A. Sisk, Robert A. Sisk, Torben Lykke Sørensen, Eric H. Souied, David-J. Spinak, Giovanni Staurenghi, Robert L. Steinmetz, Glenn Stoller, Robert Stoltz, Eric Suan, Iván J. Suñer, Yzer Suzanne, Ramin Tadayoni, Kanji Takahashi, Kei Takayama, Alexandre Chater Taleb, James Talks, Hiroko Terasaki, John F. Thompson, Edit Tóth‐Molnár, Khoi Tran, Raman Tuli, Eduardo Uchiyama, Attila Vajas, Janneke Van Lith-Verhoeven, Balázs Varsányi, Francesco Viola, Gianni Virgili, Gábor Vogt, Michael Völker, David Warrow, Pamela Weber, John A. Wells, Sanjeewa Wickremasinghe, Mark R. Wieland, Geoff Williams, Thomas N. Williams,
Summary Background Faricimab is a bispecific antibody that acts through dual inhibition of both angiopoietin-2 and vascular endothelial growth factor A. We report primary results of two phase 3 trials evaluating intravitreal faricimab with extension up to every 16 weeks for neovascular age-related macular degeneration (nAMD). Methods TENAYA and LUCERNE were randomised, double-masked, non-inferiority trials across 271 sites worldwide. Treatment-naive patients with nAMD aged 50 years or older were randomly ...
Elsevier BV
Yuming Chen, Zhihao Zhai, Hefei Li, Shuhei Yamada, Takashi Matsuoka, Shinji Ono, Tamaki Nakano,
To assess the influence of liquid attached on the tooth surfaces on the accuracy (trueness and precision) of intraoral scanners and the effectiveness of the drying method (using compression air) to exclude the influence of liquid on the scanning results.A mandibular jaw model was scanned using an industrial computed tomography scanner to obtain a reference model. A scanning platform was designed to simulate three specific tooth surface states (dry, wet, blow-dry). Two kinds of liquids (ultra-pure water ...
Tópico(s): Endodontics and Root Canal Treatments
2021 - Wiley | Journal of Prosthodontics
Atsushi Matsumura, Tamaki Nakano, Shinji Ono, Akihiro Kaminaka, Hirofumi Yatani, Daijiro Kabata,
In dental implant treatment, the placement position of the implant body is important. The hypothesis is that there are factors that have a greater impact than the factors that have been studied so far.The deviation between planned and actually placed implants was measured three-dimensionally by modified treatment evaluation method in 110 patients who underwent implant placement with guided surgery for partial edentulism. Ten factors that seemed to affect errors in placement were selected: the type ...
Tópico(s): Dental Radiography and Imaging
2021 - Springer Science+Business Media | International Journal of Implant Dentistry
Keiko Aota, Tomoko Yamanoi, Koichi Kani, Shinji Ono, Yukihiro Momota, Masayuki Azuma,
Tópico(s): Chemokine receptors and signaling
2020 - Springer Science+Business Media | Inflammation
Haruka Araki, Tamaki Nakano, Shinji Ono, Hirofumi Yatani,
When using short implants, fracture of the implant body and bone resorption are a concern because stress concentrates on and around a short implant. The purpose of this research is to investigate the differences in stress distribution between tissue level (TL) and bone level (BL) implant body designs, and between commercially pure titanium (cpTi) and the newer titanium-zirconium (TiZr) alloy in using short implants.Models of TL and BL implants were prepared for three-dimensional finite element analysis. ...
Tópico(s): Dental materials and restorations
2020 - Springer Science+Business Media | International Journal of Implant Dentistry
Yoshiro Morimoto, Shintaro Yoshida, Akira Kinoshita, Chisei Satoh, Hiroyuki Mishima, Naohiro Yamaguchi, Katsuya Matsuda, Miako Sakaguchi, Takeshi Tanaka, Yoshihiro Komohara, Akira Imamura, Hiroki Ozawa, Masahiro Nakashima, Naohiro Kurotaki, Tatsuya Kishino, Koh-ichiro Yoshiura, Shinji Ono,
To identify genes related to normal-pressure hydrocephalus (NPH) in one Japanese family with several members with NPH.We performed whole-exome sequencing (WES) on a Japanese family with multiple individuals with NPH and identified a candidate gene. Then we generated knockout mouse using CRISPR/Cas9 to confirm the effect of the candidate gene on the pathogenesis of hydrocephalus.In WES, we identified a loss-of-function variant in CFAP43 that segregated with the disease. CFAP43 encoding cilia- and flagella- ...
Tópico(s): Fetal and Pediatric Neurological Disorders
2019 - Lippincott Williams & Wilkins | Neurology
Yoshiro Morimoto, Mihoko Shimada‐Sugimoto, Takeshi Otowa, Shintaro Yoshida, Akira Kinoshita, Hiroyuki Mishima, Naohiro Yamaguchi, Takatoshi Mori, Akira Imamura, Hiroki Ozawa, Naohiro Kurotaki, Christiane Ziegler, Katharina Domschke, Jürgen Deckert, Tadashi Umekage, Mamoru Tochigi, Hisanobu Kaiya, Yuji Okazaki, Katsushi Tokunaga, Takehiko Sasaki, Koh-ichiro Yoshiura, Shinji Ono,
Panic disorder (PD) is characterized by recurrent and unexpected panic attacks, subsequent anticipatory anxiety, and phobic avoidance. Recent epidemiological and genetic studies have revealed that genetic factors contribute to the pathogenesis of PD. We performed whole-exome sequencing on one Japanese family, including multiple patients with panic disorder, which identified seven rare protein-altering variants. We then screened these genes in a Japanese PD case-control group (384 sporadic PD patients ...
Tópico(s): Genetic Associations and Epidemiology
2018 - Springer Nature | Translational Psychiatry
Akira Nishi, Shusuke Numata, Atsushi Tajima, Xiaolei Zhu, Koki Ito, Atsushi Saito, Yusuke Kato, Makoto Kinoshita, Shinji Shimodera, Shinji Ono, Shinichiro Ochi, Akira Imamura, Naohiro Kurotaki, Shu-ichi Ueno, Nakao Iwata, Kiyoshi Fukui, Issei Imoto, Atsushi Kamiya, Tetsuro Ohmori,
Here we report de novo non-synonymous single-nucleotide variants (SNVs) by conducting whole exome sequencing of 18 trios consisting of Japanese patients with sporadic schizophrenia and their parents. Among nine SNVs, we explored the functional impact of the de novo mutation in TBL1XR1 [c.30 C > G (p.Phe10Leu)], a gene previously found to be associated with autism spectrum disorder and epilepsy. Protein structural analysis revealed that Phe10Leu mutation may decrease the structural stability of the TBL1XR1 ...
Tópico(s): Congenital heart defects research
2017 - Nature Portfolio | Scientific Reports
Masanobu Sagisaka, Shinji Ono, Craig James, Atsushi Yoshizawa, Azmi Mohamed, Frédéric Guittard, Robert M. Enick, Sarah E. Rogers, Adam Czajka, Christopher Hill, Julian Eastoe,
Previous work (M. Sagisaka, et al. Langmuir 31 (2015) 7479-7487), showed the most effective fluorocarbon (FC) and hydrocarbon (HC) chain lengths in the hybrid surfactants FCm-HCn (sodium 1-oxo-1-[4-(perfluoroalkyl)phenyl]alkane-2-sulfonates, where m = FC length and n = HC length) were m and n = 6 and 4 for water solubilization, whereas m 6 and n 6, or m 6 and n 5, were optimal chain lengths for reversed micelle elongation in supercritical CO2. To clarify why this difference of only a few methylene chain units ...
Tópico(s): Ionic liquids properties and applications
2017 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Yoshiro Morimoto, Shinji Ono, Akira Imamura, Yuji Okazaki, Akira Kinoshita, Hiroyuki Mishima, Hideyuki Nakane, Hiroki Ozawa, Koh-ichiro Yoshiura, Naohiro Kurotaki,
Monozygotic (MZ) twins have been thought to be genetically identical. However, recent studies have shown discordant variants between them. We performed whole-exome sequencing (WES) in five MZ twin pairs with discordant neurodevelopmental disorders and one healthy control MZ twin to detect discordant variants. We identified three discordant variants confirmed by deep sequencing after analysis by personalized next-generation sequencing (NGS). Three mutations in FBXO38 (chr5:147774428;T>G), SMOC2 (chr6: ...
Tópico(s): Genomic variations and chromosomal abnormalities
2017 - Springer Nature | Human Genome Variation
Masanobu Sagisaka, Shinji Ono, Craig James, Atsushi Yoshizawa, Azmi Mohamed, Frédéric Guittard, Sarah E. Rogers, Richard K. Heenan, Ci Yan, Julian Eastoe,
Hybrid surfactants containing both fluorocarbon (FC) and hydrocarbon (HC) chains have recently been shown to solubilize water and form elongated reversed micelles in supercritical CO2. To clarify the most effective FC and HC chain lengths, the aggregation behavior and interfacial properties of hybrid surfactants FCm-HCn (FC length m/HC length n = 4/2, 4/4, 6/2, 6/4, 6/5, 6/6, and 6/8) were examined in W/CO2 mixtures as functions of pressure, temperature, and water-to-surfactant molar ratio (W0). The solubilizing ...
Tópico(s): Adsorption, diffusion, and thermodynamic properties of materials
2015 - American Chemical Society | Langmuir
Akito Shimouchi, Harumasa Yokota, Shinji Ono, Chiemi Matsumoto, Toshihiro Tamai, Hiroko Takumi, Subbadra P. Narayanan, Shoji Kimura, Hiroya Kobayashi, Ruth B. Caldwell, Taiji Nagaoka, Akitoshi Yoshida,
To determine whether water-dispersible hesperetin (WD-Hpt) can prevent degeneration of ganglion cell neurons in the ischemic retina. Ischemia reperfusion (I/R) injury was induced by increasing the intraocular pressure of mice to 110 mmHg for 40 min. Mice received daily intraperitoneal injections with either normal saline (NS, 0.3 ml/day) or WD-Hpt (0.3 ml, 200 mg/kg/day). Reactive oxygen species (ROS) was assessed by dihydroethidium and nitrotyrosine formation. Inflammation was estimated by microglial ...
Tópico(s): Retinal Diseases and Treatments
2015 - Springer Science+Business Media | Japanese Journal of Ophthalmology
Azmi Mohamed, Tretya Ardyani, Masanobu Sagisaka, Shinji Ono, Tsuyoshi Narumi, Makoto Kubota, Paul Brown, Craig James, Julian Eastoe, Azlan Kamari, Norhayati Hashim, Illyas Md Isa, Suriani Abu Bakar,
The relationship between the tail architecture and performance of hybrid AOT analogue surfactants has been investigated. Three hybrid surfactants were synthesised using hydrocarbon CO2-philic tails with different levels of chain branching. The performance of each surfactant was investigated via high-pressure phase behaviour, UV-visible spectroscopy, and air–water (a/w) surface tension measurements. Notably, the incorporation of hydrocarbon CO2-philic tails with a high degree of branching has been ...
Tópico(s): Membrane Separation and Gas Transport
2015 - Elsevier BV | The Journal of Supercritical Fluids
Akihiro Kaminaka, Tamaki Nakano, Shinji Ono, Tokinori Kato, Hirofumi Yatani,
Abstract Purpose This study evaluated changes in the horizontal and vertical dimensions of the buccal alveolar bone and soft tissue over a 1‐year period following implant prosthesis. Materials and Methods Thirty‐three participants with no history of guided bone regeneration or soft tissue augmentation underwent dental implant placement with different types of connections. The dimensions of the buccal alveolar bone and soft tissue were evaluated immediately and at 1 year after prosthesis from reconstructions ...
Tópico(s): Periodontal Regeneration and Treatments
2014 - Wiley | Clinical Implant Dentistry and Related Research
Takashi Kimoto, Dai Mizuno, Tsunetomo Takei, Takuya Kunimi, Shinji Ono, Satoko Sakai, Hiroshi Kido,
Background We found previously that bovine pulmonary Surfacten ® used in newborns with acute respiratory distress syndrome is a safe and efficacious antigen vehicle for intranasal vaccination. Objectives The objective of this study was to industrially produce a synthetic adjuvant mimicking Surfacten ® for clinical use without risk of bovine spongiform encephalopathy. Methods We selected three S urfacten lipids and surfactant protein ( SP )‐C as essential constituents for adjuvanticity. For replacement of ...
Tópico(s): Respiratory viral infections research
2013 - Wiley | Influenza and Other Respiratory Viruses
Bruce D. Uhal, Hang Thi Thu Nguyen, MyTrang Dang, Indiwari Gopallawa, Jing Jiang, Vinh Dang, Shinji Ono, Konosuke Morimoto,
Earlier work showed that apoptosis of alveolar epithelial cells (AECs) in response to endogenous or xenobiotic factors is regulated by autocrine generation of angiotensin (ANG) II and its counterregulatory peptide ANG1-7. Mutations in surfactant protein C (SP-C) induce endoplasmic reticulum (ER) stress and apoptosis in AECs and cause lung fibrosis. This study tested the hypothesis that ER stress-induced apoptosis of AECs might also be regulated by the autocrine ANGII/ANG1-7 system of AECs. ER stress ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2013 - American Physical Society | AJP Lung Cellular and Molecular Physiology
Masanobu Sagisaka, Shuho Iwama, Shinji Ono, Atsushi Yoshizawa, Azmi Mohamed, Stephen Cummings, Ci Yan, Craig James, Sarah E. Rogers, Richard K. Heenan, Julian Eastoe,
High-pressure small-angle neutron scattering (HP-SANS) studies were conducted to investigate nanostructures and interfacial properties of water-in-supercritical CO2 (W/CO2) microemulsions with double-fluorocarbon-tail anionic surfactants, having different fluorocarbon chain lengths and linking groups (glutarate or succinate). At constant pressure and temperature, the microemulsion aqueous cores were found to swell with an increase in water-to-surfactant ratio, W0, until their solubilizing capacities ...
Tópico(s): Catalysis and Oxidation Reactions
2013 - American Chemical Society | Langmuir
Ichiro Tanano, Taiji Nagaoka, Tsuneaki Omae, Akihiro Ishibazawa, Takayuki Kamiya, Shinji Ono, Akitoshi Yoshida,
Cilostazol, a selective inhibitor of phosphodiesterase 3, has antiplatelet aggregation and peripheral vasodilation effects. We examined the effects of cilostazol on the retinal microvascular diameter to determine its dependence on the endothelium and/or smooth muscle to reveal the signaling mechanisms involved in this vasomotor activity.Porcine retinal arterioles were isolated, cannulated, and pressurized without flow in vitro. Video microscopic techniques recorded the diametric responses to cilostazol. ...
Tópico(s): Retinal Diseases and Treatments
2013 - Cadmus Press | Investigative Ophthalmology & Visual Science
Akihiro Ishibazawa, Taiji Nagaoka, Harumasa Yokota, Shinji Ono, Akitoshi Yoshida,
The vascular endothelium responds to shear stress generated by blood flow and changes functions to regulate blood flow and maintain tissue homeostasis. Recently, we found that arteriolar high shear stress leads to increased expression of vasodilatory and antithrombotic genes in human retinal microvascular endothelial cells (HRMECs). However, it is unknown whether low shear stress, which is induced by hypoperfusion particularly in the retinal venules where leukocyte-endothelial interactions mainly ...
Tópico(s): Retinal and Optic Conditions
2013 - Elsevier BV | Experimental Eye Research
Yuka Nakazawa, Kensaku Sasaki, Norisato Mitsutake, Michiko Matsuse, Mayuko Shimada, Tiziana Nardò, Yoshito Takahashi, Kaname Ohyama, Kosei Ito, Hiroyuki Mishima, Masayo Nomura, Akira Kinoshita, Shinji Ono, Katsuya Takenaka, Ritsuko Masuyama, Takashi Kudo, Hanoch Slor, Atsushi Utani, Satoshi Tateishi, Shunichi Yamashita, Miria Stefanini, Alan R. Lehmann, Koh-ichiro Yoshiura, Tomoo Ogi,
UV-sensitive syndrome (UV(S)S) is a genodermatosis characterized by cutaneous photosensitivity without skin carcinoma. Despite mild clinical features, cells from individuals with UV(S)S, like Cockayne syndrome cells, are very UV sensitive and are deficient in transcription-coupled nucleotide-excision repair (TC-NER), which removes DNA damage in actively transcribed genes. Three of the seven known UV(S)S cases carry mutations in the Cockayne syndrome genes ERCC8 or ERCC6 (also known as CSA and CSB, ...
Tópico(s): RNA modifications and cancer
2012 - Nature Portfolio | Nature Genetics
Shinji Ono, Koh-ichiro Yoshiura, Akira Kinoshita, Taeko Kikuchi, Yoshibumi Nakane, Nobumasa Kato, Miyuki Sadamatsu, Tohru Konishi, Shinichiro Nagamitsu, Masato Matsuura, Ayako Yasuda, Maki Komine, Kazuaki Kanai, Takeshi Inoue, Toshio Osamura, Kayoko Saito, Shinichi Hirose, Hiroyoshi Koide, Hiroaki Tomita, Hiroki Ozawa, Norio Niikawa, Naohiro Kurotaki,
Paroxysmal kinesigenic dyskinesia (PKD (MIM128000)) is a neurological disorder characterized by recurrent attacks of involuntary movements. Benign familial infantile convulsion (BFIC) is also one of a neurological disorder characterized by clusters of epileptic seizures. The BFIC1 (MIM601764), BFIC2 (MIM605751) and BFIC4 (MIM612627) loci have been mapped to chromosome 19q, 16p and 1p, respectively, while BFIC3 (MIM607745) is caused by mutations in SCN2A on chromosome 2q24. Furthermore, patients with BFIC ...
Tópico(s): Genomics and Rare Diseases
2012 - Springer Nature | Journal of Human Genetics
Makoto Kinoshita, Shusuke Numata, Atsushi Tajima, Shinji Shimodera, Shinji Ono, Akira Imamura, Jun‐ichi Iga, Shinya Watanabe, Kumiko Kikuchi, Hiroko Kubo, Masahito Nakataki, Satsuki Sumitani, Issei Imoto, Yuji Okazaki, Tetsuro Ohmori,
Tópico(s): Genetics and Neurodevelopmental Disorders
2012 - Springer Science+Business Media | NeuroMolecular Medicine
Naohiro Kurotaki, Shinya Tasaki, Hiroyuki Mishima, Shinji Ono, Akira Imamura, Taeko Kikuchi, Nao Nishida, Katsushi Tokunaga, Koh-ichiro Yoshiura, Hiroki Ozawa,
The recent development of high-resolution DNA microarrays, in which hundreds of thousands of single nucleotide polymorphisms (SNPs) are genotyped, enables the rapid identification of susceptibility genes for complex diseases. Clusters of these SNPs may show runs of homozygosity (ROHs) that can be analyzed for association with disease. An analysis of patients whose parents were first cousins enables the search for autozygous segments in their offspring. Here, using the Affymetrix® Genome-Wide Human ...
Tópico(s): Genomic variations and chromosomal abnormalities
2011 - Public Library of Science | PLoS ONE