The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Recently, a mouse brain-specific Shisa protein CKAMP44 (Shisa9) was shown to play an ... study the evolutionary origin and phylogenetic distribution of Shisa homologs. In addition to nine Shisa subfamilies in vertebrates, we detected distantly related Shisa homologs that possess an N-terminal domain with ...
Tópico(s): Antimicrobial Peptides and Activities
2011 - Elsevier BV | Cellular Signalling
Akihito Yamamoto, Takashi Nagano, Shoko Takehara, Masahiko Hibi, Shinichi Aizawa,
... against Wnt and FGF signaling for head formation, Shisa, which functions cell autonomously in the endoplasmic reticulum (ER). Shisa is specifically expressed in the prospective head ectoderm ... the Spemann organizer of Xenopus gastrulae. Overexpression of Shisa inhibited both Wnt and FGF signaling in Xenopus embryos and in a cell line. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation. Shisa physically interacted with immature forms of the Wnt ...
Tópico(s): Epigenetics and DNA Methylation
2005 - Cell Press | Cell
Mário Filipe, Lisa Gonçalves, Margaret Bento, Ana Cristina Silva, José António Belo,
... differentiation, and tissue patterning. The recently identified Xenopus Shisa protein promotes head formation by inhibiting Wnt and ... describe the mouse and chicken homologues of Xenopus Shisa. The mouse and chicken Shisa proteins share, respectively, 33.6% and 33.8% ... homolog. In situ hybridization analysis shows that mouse shisa is expressed throughout embryonic development, predominantly in the ... that of mshisa . Our observations indicate that the Shisa family genes are typically expressed in tissues known ...
Tópico(s): Congenital heart defects research
2006 - Wiley | Developmental Dynamics
Ana-Cristina Silva, Mário Filipe, Marta Vitorino, Herbert Steinbeißer, José António Belo,
Shisa is an antagonist of Wnt and FGF signaling, that functions cell autonomously in the endoplasmic reticulum ( ... we report the isolation of a second Xenopus shisa gene (Xshisa-2) . Xenopus Shisa-2 shows 30.7% identity to Xshisa. RT- ... neurula and tailbud stages. At neurula stages Xenopus shisa-2 is initially expressed in the presomitic paraxial ...
Tópico(s): Congenital heart defects research
2006 - University of the Basque Country | The International Journal of Developmental Biology
... pathways network together during carcinogenesis and embryogenesis. Xenopus shisa is claimed to inhibit the post-translational maturation ... receptors. Here, we identified and characterized the rat Shisa (Tmem46) gene by using bioinformatics for comparative proteomics and comparative genomics analyses. Rat Shisa gene, consisting of two exons, was located within AC126002.4 genome sequence. Shisa gene at rat chromosome 15p12 was found to ... 38.6% total-amino-acid identity with mouse Shisa, human SHISA, chicken shisa, Xenopus shisa and zebrafish ...
Tópico(s): Epigenetics and DNA Methylation
2005 - Spandidos Publishing | International Journal of Molecular Medicine
K Nakakuki, Hayase Shisa, Yasuaki Nishizuka,
... author on: This Site PubMed Google Scholar H. Shisa; H. Shisa Department of Pathology, Mie Prefectural University School of ... Icon Cite Search Site Citation K. Nakakuki, H. Shisa, Y. Nishizuka; Prevention of AKR Leukemia by Thymectomy ...
Tópico(s): Plant Disease Management Techniques
1967 - Karger Publishers | Acta Haematologica
Mazyar Abdollahi Nejat, Remco V. Klaassen, Sabine Spijker, August B. Smit,
... interacting auxiliary proteins, highlights recent results regarding the Shisa protein family, and provides a discussion on future ...
Tópico(s): Receptor Mechanisms and Signaling
2021 - Elsevier BV | Current Opinion in Pharmacology
Nari Kim, Tae-Hyeon Kim, Chaelim Kim, Jee‐Eun Lee, Myeong‐Gyun Kang, Sanghee Shin, Minkyo Jung, Jong‐Seo Kim, Ji Young Mun, Hyun‐Woo Rhee, Seung‐Yeol Park, Yongdae Shin, Joo‐Yeon Yoo,
... selectively sequestered into the biomolecular condensate of SCOTIN/SHISA-5, which interferes with COPII vesicle formation and ...
Tópico(s): RNA regulation and disease
2023 - Elsevier BV | Developmental Cell
Young Jae Bahn, Kwang‐Pyo Lee, Seung-Min Lee, Jeong Yi Choi, Yeon‐Soo Seo, Ki‐Sun Kwon,
... S. Osawa N. Buchberg A.M. Moriwaki K. Shisa H. et al.Cloning and characterization of the ... S. Osawa N. Buchberg A.M. Moriwaki K. Shisa H. et al.Cloning and characterization of the ...
Tópico(s): Heat shock proteins research
2014 - Elsevier BV | Journal of Lipid Research
Shisa proteins are a recently-identified family of modulators of both FGF and Wnt signaling that block ... role in head development as demonstrated for Xenopus Shisa, being ubiquitously expressed in anterior tissues. However, expression ...
Tópico(s): Fibroblast Growth Factor Research
2007 - University of the Basque Country | The International Journal of Developmental Biology
Kenryo Furushima, Akihito Yamamoto, Takashi Nagano, Mikihito Shibata, Hitoshi Miyachi, Takaya Abe, Naoko Ohshima, Hiroshi Kiyonari, Shinichi Aizawa,
... mShisa mutants exhibited no defects in head development. Shisa is composed of five subfamilies, but normal head ...
Tópico(s): Developmental Biology and Gene Regulation
2007 - Elsevier BV | Developmental Biology
Dantong Wang, Xavier De Deken, Milutin Milenkovic, Yue Song, Isabelle Pirson, Jacques E. Dumont, Françoise Miot,
... S. Osawa N. Buchberg A.M. Moriwaki K. Shisa H. Honjo T. Genomics. 1997; 39: 331-339Crossref ... S. Osawa N. Buchberg A.M. Moriwaki K. Shisa H. Honjo T. Genomics. 1997; 39: 331-339Crossref ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
2004 - Elsevier BV | Journal of Biological Chemistry
Yoshiyuki Matsuo, Nobutake Akiyama, Hajime Nakamura, Junji Yodoi, Makoto Noda, Shinae Kizaka‐Kondoh,
... S. Osawa N. Buchberg A.M. Moriwaki K. Shisa H. Honjo T. Genomics. 1997; 39: 331-339Crossref ... S. Osawa N. Buchberg A.M. Moriwaki K. Shisa H. Honjo T. Genomics. 1997; 39: 331-339Crossref ...
Tópico(s): Heat shock proteins research
2001 - Elsevier BV | Journal of Biological Chemistry
Tomomi Kamba, Shin Higashi, Toshiyuki Kamoto, Hayase Shisa, Yoshihiro Yamada, Osamu Ogawa, Hiroshi Hiai,
... 9503Crossref PubMed Scopus (86) Google Scholar, 22Yamada Y Shisa H Matsushiro H Kamoto T Kobayashi Y Kawarai ...
Tópico(s): Prenatal Screening and Diagnostics
2001 - Elsevier BV | American Journal Of Pathology
Hani Sabaie, Mahnaz Talebi, Jalal Gharesouarn, Mohammad Reza Asadi, Abbas Jalaiei, Shahram Arsang‐Jang, Bashdar Mahmud Hussen, Mohammad Taheri, Reza Jalili Khoshnoud, Maryam Rezazadeh,
... of the most intriguing new members of the SHISA family, in that, unlike other CKAMP counterparts, it ...
Tópico(s): RNA regulation and disease
2022 - Frontiers Media | Frontiers in Aging Neuroscience
Ele Ferrannini, Maria Laura Manca, Giulia Ferrannini, Felicita Andreotti, Daniele Andreini, Roberto Latini, Marco Magnoni, Stephen A. Williams, Attilio Maseri, Aldo P. Maggioni,
... chemokine-22 (C-C-22), and reduced protein shisa-3 homolog (PS-3) and platelet-activating factor ...
Tópico(s): Lipoproteins and Cardiovascular Health
2022 - Frontiers Media | Frontiers in Cardiovascular Medicine
Hiroyuki Ohta, Toru Miyake, Tomoyuki Ueki, M. Kojima, Masayasu Kawasaki, Takeshi Tatsuta, Takekazu Iuchi, Sumihiro Kamitani, Tomoharu Shimizu, Eiji Mekata, Masaji Tani,
Abstract Purpose Postoperative diarrhea, including high-output stoma (HOS), frequently occurs after colorectal surgery; its risk factors and clinical implications on subsequent complications remain unknown. This study aimed to evaluate the risk factors and clinical implications of postoperative diarrhea after primary colorectal cancer (CRC) surgery. Methods This prospective observational study included patients with CRC who underwent radical surgery at six hospitals between June 2016 and December ...
Tópico(s): Microscopic Colitis
2022 - Springer Science+Business Media | International Journal of Colorectal Disease
Hani Sabaie, Jalal Gharesouran, Mohammad Reza Asadi, Sara Farhang, Noora Karim Ahangar, Serge Brand, Shahram Arsang‐Jang, Saba Dastar, Mohammad Taheri, Maryam Rezazadeh,
... miR-185-5p and its corresponding target gene, shisa family member 7 (SHISA7), sometimes called CKAMP59, were ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2022 - Springer Science+Business Media | Metabolic Brain Disease
Shuisheng Long, Xiaohui Dong, Beiping Tan, Shuang Zhang, Shuyan Chi, Qihui Yang, Hongyu Liu, Shiwei Xie, Junming Deng, Yuanzhi Yang, Haitao Zhang,
... S-adenosylmethionine synthase isoform type-2 (SAM2), protein shisa-5-like (SHISA5), and growth arrest and DNA ...
Tópico(s): Biochemical effects in animals
2021 - Elsevier BV | Aquaculture
Sachiko Kaida, Toru Miyake, Satoshi Murata, Tsuyoshi Yamaguchi, Takeshi Tatsuta, Koichiro Murakami, Hiroshi Okauchi, Shoichi Nishimura, Hiroyuki Ohta, Hiroshi Tsuchihashi, Masayasu Kawasaki, Katsushi Takebayashi, Tomoharu Shimizu, Masaji Tani,
<b><i>Introduction:</i></b> This study aimed to clarify the frequency and risk factors of intercurrent venous thromboembolism (VTE) in patients undergoing major curative gastric cancer surgery. <b><i>Methods:</i></b> This prospective, multicenter, observational study included patients with gastric cancer who underwent radical gastrectomy at 5 hospitals between June 2016 and May 2018. Patients who were preoperatively administered anticoagulants were excluded. < ...
Tópico(s): Acute Myocardial Infarction Research
2021 - Karger Publishers | European Surgical Research
David Ramos-Vicente, Àlex Bayés,
... to four unrelated protein families: CACNG-GSG1, cornichon, shisa and Dispanin C. Our study demonstrates that, despite ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2020 - Royal Society | Open Biology
Yoto Komeda, Toshiharu Mita, Yoshimi Hirose, Kenzo Yamagishi,
... Among the species of the charon -group, G. shisa sp. nov. is newly described. Gryon hakonense (Ashmead) ...
Tópico(s): Fossil Insects in Amber
2020 - Pensoft Publishers | Journal of Hymenoptera Research
Kenji Tamura, Mutsuo Furihata, Hirofumi Satake, Hatsune Hashida, Chiaki Kawada, Hiroto Osakabe, Hideo Fukuhara, Naoko Kumagai, Tatsuo Iiyama, Taro Shuin, Keiji Inoue,
... First, a novel molecular target and diagnostic biomarker, shisa family member 2 (SHISA2), was identified as an ...
Tópico(s): Prostate Cancer Treatment and Research
2017 - Spandidos Publishing | Oncology Letters
Elizabeth D. Justice, Sarah J. Barnum, Thomas Kidd,
... by co-expression of PRRG4, but not CYYR, Shisa or the yeast Rcr genes. In cell culture ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2017 - Public Library of Science | PLoS Genetics
Pablo Galaz‐Davison, Rafael Barra, Héctor Figueroa, Trinidad Mariqueo,
... and 2. AMPA receptors are modulated by TARPs, Shisa 9, CKAMP44, CNIH2-3 auxiliary proteins reported that ...
Tópico(s): Receptor Mechanisms and Signaling
2015 - Elsevier BV | Pharmacological Research
Tetsuya Mori, Eisuke Chikayama, Yuuri Tsuboi, Nobuhiro Ishida, Noriko Shisa, Yoshiyuki Noritake, Shigeharu Moriya, Jun Kikuchi,
(13)C-labeled amorphous cellulose and (13)C NMR chemical shifts by 2D (13)C-(13)C correlation spectroscopy were obtained in the regenerated solid-state from ionic liquids. On the basis of the assigned chemical shifts, combined with information from molecular dynamics and quantum chemistry computer simulations a twisted structure for amorphous cellulose is proposed exposing more hydrophilic surface than that of extended crystalline cellulose.
Tópico(s): Catalysis for Biomass Conversion
2012 - Elsevier BV | Carbohydrate Polymers
AbstractRepresentations of indigenous Okinawa shisa (Japan) and Kinmen wind lion totems (Taiwan) are popular tourist souvenirs. They are also commonly used in destination tourism promotion ...
Tópico(s): Media, Gender, and Advertising
2011 - Taylor & Francis | Journal of Sustainable Tourism
Bryan T. MacDonald, Mikhail V. Semënov, Xi He,
... to the plasma membrane, and the ER protein Shisa prevents folding and trafficking of the Fz protein ...
Tópico(s): Cancer-related gene regulation
2007 - Cell Press | Cell
Takashi Nagano, Shoko Takehara, Maiko Takahashi, Shinichi Aizawa, Akihito Yamamoto,
... show that Shisa2, a member of a novel Shisa gene family, plays an essential role in segmental ...
Tópico(s): Congenital heart defects research
2006 - The Company of Biologists | Development
Kotaro Ogawa, Jun‐ichi Tanuma, Masato Hirano, Yoshikazu Hirayama, Ichiro Semba, Hayase Shisa, Motoo Kitano,
Tópico(s): MicroRNA in disease regulation
2006 - Elsevier BV | Oral Oncology