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By Peter Jay Economics Editor, By Peter Waymark, By Our Political Editor, From Patrick Brogan and Charles Hargrove, From Ian McDonald, By a Staff Reporter, From Peter Hazelhurst, By Stephen Jessel Education Correspondent, By Paul Routledge Labour Staff, From Our Correspondent, By Arthur Reed Air Correspondent, By Our Parliamentary Correspondent, By Hugh Noyes Parliamentary Correspondent, By Alan Hamilton Labour Staff, By Pearce Wright Science Correspondent, By Brian Cashinella, By Geraldine Keen Sale Room Correspondent, By Tony Aldous Environment Reporter, By Robert Fisk, By John Roper Medical Reporter, By Philip Howard, By Pat Healy Social Services Correspondent, By Clive Borrell, From Peter Evans Home Affairs Correspondent, By George Clark Political Staff, By A. M. Rendel Diplomatic Correspondent, From Roger Berthoud, From Our Own Correspondent, From Leo Goodstadt, From Michael Leapman, From James Morgan, From Dan van der Vat, From Richard Wigg, From Our Latin America Correspondent, Ray Gosling, David Cheshire, Gudrun Tempel, Michael Wood, Edward Mortimer, Jacky Gillott, Marghanita Laski, From Geoffrey Green Football Correspondent, By Norman Fox, By Rex Bellamy Tennis Correspondent, By John Woodcock Cricket Correspondent, By Alan Gibson, From Neil Allen, From Terry McLean, By Richard Streeton, By Michael Phillips Racing Correspondent, By Jim Snow Northern Racing Correspondent, By Peter Ryde Golf Correspondent, MR. AMERY-Yes., Miles Copeland, Michael Baily, PHS, ANDREW WRIGHT, BASIL TAYLOR., LINCOLN HALLINAN., HAROLD ROSENTHAL, , W. McC. STEWART., A. J. HANNA, D. LINDSAY KEIR., DAVID GOODENDAY., SYLVIA HAYMON., JOHN UNDERWOOD., MAURICE PARTRIDGE., JASON DITTON, KINNOULL., RAMSEY BRONK, CYRIL E. ROBINSON., TREVOR L.J. BURFIELD, , DEREK WATERS., By Giles Smith, From Anthony Thomas, By Melvyn Westlake, By Dennis Dwyer, By Our Northern Industrial Correspondent, By Clifford Webb, By R. W. Shakespeare, By Our Midland Industrial Correspondent, By Peter Hill, By Michael Thomas Labour Correspondent, From Our U.S. Economics Correspondent, From Alan McGregor, From Frank Vogl, By Our Labour Correspondent, BY THE FINANCIAL EDITOR, DR. STANLEY GILL., RONALD INGHAM., COLIN G. SOUTHGATE., T. KING., E.R.BRAY., CYRIL GRUNFELD., CHARLES M. GOLDSMITH., By Hugh Stephenson, By C. B. B. Grindley and J. W. Humble, Julian Mounter,

... London news. Index. Display Advertising: Air Ionization, Mitsubishi Shoji Kaisha, Limited, Routledge, Gill & Duffus, Times Newspapers Limited,, ... Kosinski, A splendid Victorian heroine Sister Dora By Jo Manton, The Quest for Christa T By Christa ...

1971 - Gale Group | TDA

Artigo Acesso aberto Revisado por pares

Shoji Osawa, Rebecca Jo, Yubin Xiong, Boris Reidel, Nomingerel Tserentsoodol, Vadim Y. Arshavsky, P. Michael Iuvone, Ellen R. Weiss,

Phosphorylation of rhodopsin by G protein-coupled receptor kinase 1 (GRK1, or rhodopsin kinase) is critical for the deactivation of the phototransduction cascade in vertebrate photoreceptors. Based on our previous studies in vitro, we predicted that Ser(21) in GRK1 would be phosphorylated by cAMP-dependent protein kinase (PKA) in vivo. Here, we report that dark-adapted, wild-type mice demonstrate significantly elevated levels of phosphorylated GRK1 compared with light-adapted animals. Based on comparatively ...

Tópico(s): Photoreceptor and optogenetics research

2011 - Elsevier BV | Journal of Biological Chemistry

Artigo Acesso aberto Revisado por pares

Shoji Osawa, Rebecca Jo, Ellen R. Weiss,

The retina-specific G protein-coupled receptor kinases, GRK1 and GRK7, have been implicated in the shutoff of the photoresponse and adaptation to changing light conditions via rod and cone opsin phosphorylation. Recently, we have defined sites of phosphorylation by cAMP-dependent protein kinase (PKA) in the amino termini of both GRK1 and GRK7 in vitro. To determine the conditions under which GRK7 is phosphorylated in vivo, we have generated an antibody that recognizes GRK7 phosphorylated on Ser36, ...

Tópico(s): Receptor Mechanisms and Signaling

2008 - Wiley | Journal of Neurochemistry

Artigo

Masato Kuchii, Shoji Shibata, Jo Mori,

1. No evidence for specific catecholamine fluorescence was found in any tissue layer of rat thoracic aorta, even after combined treatment with iproniazid and L-DOPA. 2. In contrast to the atria and abdominal aorta, reserpine (4 mg. per kg.) or 6-hydroxydopamine (50 mg. per kg.) did not affect the catecholamine content of the thoracic aorta. 3. Cocaine (10−5M) or desipramine (10−6M) exerted a similar differential inhibition on [3H]noradrenaline uptake by aortic tissues. 4. After pretreatment with cocaine ( ...

Tópico(s): Veterinary Pharmacology and Anesthesia

1973 - Elsevier BV | Comparative and General Pharmacology

Artigo Acesso aberto Revisado por pares

Keisuke Hattori, Kazuyoshi Kurahashi, Jo Mori, Shoji Shibata,

Summary In the guinea‐pig taenia caecum, fluorescent adrenergic fibres terminate in both muscle layers. The density of these fibres is greater in the taenia than in the underlying circular muscle layer. The myenteric plexus and individual ganglion cells are also densely innervated by intensely fluorescent adrenergic nerve fibres. After three days of cold storage, the specific fluorescence disappeared from all tissue layers of the taenia caecum and smooth muscle fibres. In contrast, cholinesterase ...

Tópico(s): Neuroscience and Neuropharmacology Research

1972 - Wiley | British Journal of Pharmacology

Artigo Acesso aberto

Yasuhisa Furuichi, Shoji Takakura, Hisashi Satoh, Jo Mori, MASANOBU KOHSAKA,

The effect of nilvadipine, a dihydropyridine type calcium channel blocker, on local cerebral blood flow (1CBF) was investigated using the autoradiographic iodo[14C]antipyrine technique in rats. In control rats, 1CBF in cortical areas and in the superior colliculus and inferior colliculus was higher than that in the hippocampus, septal nucleus, globus pallidus and substantia nigra. Nilvadipine (32 μg/kg, i.v.) increased 1CBF in all structures (significantly in 11 of 21 structures) in spite of a 33% ...

Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances

1992 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology

Artigo Acesso aberto

Shoji Takakura, Teruo Susumu, Hisashi Satoh, Jo Mori, Akihiko Shiino, Jyoji Handa,

The effects of nilvadipine, a dihydropyridine type calcium channel blocker, on cerebral infarction induced by focal brain ischemia was studied in rats. The area of infarction was measured 24 hr after occlusion of the middle cerebral artery (MCA) in spontaneously hypertensive rats using triphenyltetrazolium chloride. Nilvadipine, given immediately after MCA occlusion, reduced the area of infarction significantly at doses of 0.32 mg/kg (i.p.) and 3.2, 10 and 32 mg/kg (p.o.). Nicardipine suppressed the ...

Tópico(s): Sphingolipid Metabolism and Signaling

1991 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology

Artigo Acesso aberto Revisado por pares

Ryuki Kinjo, Yuya Morimoto, Byeongwook Jo, Shoji Takeuchi,

Summary Biohybrid robots fabricated by integrating mechanical components with biological materials have recently attracted attention for the development of robots having advanced biomaterial functions. Rapid progress in biohybrid robots, in which the skeletal muscle tissue is formed on a flexible substrate, has enabled various types of robot locomotion powered by muscle tissue. Conventional biohybrid robots can perform straight-line motions or large turning movements; however, they have difficulty with ...

Tópico(s): Advanced Materials and Mechanics

2024 - Elsevier BV | Matter

Artigo Revisado por pares

Norio Terada, Shoji Ishibashi, Masatoshi Jo, Masayuki Hirabayashi, Hideo Ihara,

In-situ X-ray photoemission spectroscopy has been performed on the surface of the [SrCuO2]n[CaCuO2]m artificial structure with so-called infinite stack of CuO2 sheets. The dependence of their valence band spectra on the termination of the film growth and the comparison with the SrCuO2 and CaCuO2 single layers have been studied. With an increase the number of the SrCuO2 blocks that cover the outermost region of the samples, an edge like structure around Fermi level appears, which is more apparent ...

Tópico(s): Electronic and Structural Properties of Oxides

1993 - Elsevier BV | Journal of Physics and Chemistry of Solids

Artigo Acesso aberto Revisado por pares

Rui Ma, Sander Reniers, Yuya Shoji, Tetsuya Mizumoto, Kevin Williams, Yuqing Jiao, Jos van der Tol,

In photonic integrated circuits (PICs), optical isolators and circulators are essential to prevent lasers from backreflections and to reroute the light flow. In this paper, an integrated polarization-independent device that can be operated as an optical isolator or an optical circulator, based on an InP membrane on silicon platform, is demonstrated. A cerium-doped yttrium iron garnet die is adhesively bonded on a Mach–Zehnder interferometer, in combination with four polarization converters. The device ...

Tópico(s): Optical Network Technologies

2021 - Optica Publishing Group | Optica

Artigo Acesso aberto Revisado por pares

Byeongwook Jo, Minghao Nie, Shoji Takeuchi,

With the current rapidly growing global population, the animal product industry faces challenges which not only demand drastically increased amounts of animal products but also have to limit the emission of greenhouse gases and animal waste. These issues can be solved by the combination of microfabrication and tissue engineering techniques, which utilize the microtissue as a building component for larger tissue assembly to fabricate animal products. Various methods for the assembly of microtissue ...

Tópico(s): Bone Tissue Engineering Materials

2021 - Portland Press | Essays in Biochemistry

Artigo Acesso aberto Revisado por pares

Shoji Takakura, Yasuhisa Furuichi, Tomoko Yamamoto, Tetsuhei Ogawa, Hisashi Satoh, Jo Mori,

Several types of antihypertensive drugs have been reported to protect stroke-prone spontaneously hypertensive rats from stroke. However, the clinical relevance remains unclear. This study was performed to investigate the effect of nilvadipine, a calcium channel blocker, on the development of neurological deficits in stroke-prone spontaneously hypertensive rats. In addition, plasma levels of nilvadipine were measured to determine the clinical relevance. Salt-loaded stroke-prone spontaneously hypertensive ...

Tópico(s): Blood Pressure and Hypertension Studies

1994 - Lippincott Williams & Wilkins | Stroke

Artigo

Shoji Takakura, Yasuhisa Furuichi, Hisashi Satoh, Jo Mori, MASANOBU KOHSAKA,

The effect of nilvadipine, a dihydropyridine-type calcium entry blocker, on neuronal function during and following ischemia was investigated with a model of focal cerebral ischemia in cats and was compared with that of nicardipine. Drugs were given intravenously 30 minutes before occlusion of the left middle cerebral artery (MCA). Occlusion of the left MCA for 60 minutes was followed by reperfusion for 90 minutes. The amplitude of the somatosensory evoked potentials (SEPs), and the residual relative ...

Tópico(s): Lipid Membrane Structure and Behavior

1992 - Elsevier BV | Surgical Neurology

Revisão Acesso aberto Revisado por pares

Jürgen Gröll, Thomas Boland, Torsten Blunk, Jason A. Burdick, Dong‐Woo Cho, Paul D. Dalton, Brian Derby, Gabor Forgács, Qing Li, Vladimir Mironov, Lorenzo Moroni, Makoto Nakamura, Wenmiao Shu, Shoji Takeuchi, Giovanni Vozzi, Tim B. F. Woodfield, Tao Xu, James J. Yoo, Jos Malda,

Biofabrication is an evolving research field that has recently received significant attention. In particular, the adoption of Biofabrication concepts within the field of Tissue Engineering and Regenerative Medicine has grown tremendously, and has been accompanied by a growing inconsistency in terminology. This article aims at clarifying the position of Biofabrication as a research field with a special focus on its relation to and application for Tissue Engineering and Regenerative Medicine. Within ...

Tópico(s): Tissue Engineering and Regenerative Medicine

2016 - IOP Publishing | Biofabrication

Artigo Revisado por pares

Byeongwook Jo, Yuya Morimoto, Shoji Takeuchi,

The emerging interest in skeletal muscle tissue originates from its unique properties that control body movements. In particular, recent research advances in engineered skeletal muscle tissue have broadened the possibilities of applications in nonclinical models. However, due to the lack of adipose tissue, current engineered skeletal muscle tissue has the limitation of satisfying in vivo-like position and proportion of intermuscular fat. Adipose tissue within the skeletal muscle affects their functional ...

Tópico(s): Advanced Sensor and Energy Harvesting Materials

2021 - Wiley | Biotechnology and Bioengineering

Artigo Revisado por pares

Norio Terada, Shoji Ishibashi, Masatoshi Jo, Masayuki Hirabayashi, Hideo Ihara, Shigeichi Yamamoto,

In situ angle resolved x-ray photoemission spectroscopy has been performed on superconducting a,b-axis oriented YBa2Cu3O7−δ epitaxial films. The relative intensities of the Cu 2p Ba 3d, and Y 3d core emissions have shown the diffraction-like dependence on the electron escape angle due to the spatial distribution of elements in the surface layer. The calculated results by the single scattering cluster model on the surface with the Cu-O outermost layer show a better agreement with the experiment than ...

Tópico(s): ZnO doping and properties

1993 - American Institute of Physics | Applied Physics Letters

Artigo Acesso aberto

Kyoichi Shimomura, Hisashi Satoh, Osamu Hirai, Jo Mori, Masaaki Tomoi, Takao Terai, Shoji Katsuki, Yukio Motoyama, Takaharu Ono,

2-Chloro-11-(2-dimethyl-aminoethoxy) dibenzo [b, f] thiepin (zotepine) is a new neuroleptic drug which is structurally different from known neuroleptics. Zotepine, chlorpromazine, propericiazine, and cyproheptadine inhibited hyperthermia induced by dosing with fenfluramine in rats in a warm environment (26-28 degrees C). Fenfluramine is known to induce hyperthermia by mediation of central serotonin. Zotepine had a 10 times or greater potency than chlorpromazine, propericiazine and cyproheptadine in ...

Tópico(s): Epilepsy research and treatment

1982 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology

Artigo Revisado por pares

Shoji Shivata, J. T. Miyahara, Jo Mori, Takeo Ohashi,

Tópico(s): Nitric Oxide and Endothelin Effects

1977 - Elsevier BV | European Journal of Pharmacology

Artigo Acesso aberto

Koichi Takeda, You Sano, Sosaku Ichikawa, Yuuki Hirata, Hitoshi Matsuki, Shoji Kaneshina,

The effect of a local anesthetic, lidocaine hydrochloride (LC x HCl), on the bilayer systems of purified egg phosphatidylcholine (EPC), dipalmitoylphosphatidylcholine (DPPC) and dioleoylphosphatidylcholine (DOPC) was studied by means of small-angle X-ray scattering (SAXS), Prodan fluorescence and electrophoretic light scattering. In the liquid crystalline phase of EPC and DOPC bilayers, the contraction of lamellar distance by ca. 0.8-1.0 nm and the decrease of average vesicle size were observed in the ...

Tópico(s): Antibiotics Pharmacokinetics and Efficacy

2009 - Japan Oil Chemists' Society | Journal of Oleo Science

Artigo Acesso aberto Revisado por pares

Shoji F. Nakayama, Annie St-Amand, Tyler Pollock, Petra Apel, Yu Ait Bamai, Dana Boyd Barr, Jos Bessems, Antonia M. Calafat, Argelia Castaño, Adrian Covaci, Radu Corneliu Duca, Sarah Faure, Karen S. Galea, Sean M. Hays, Nancy B. Hopf, Yuki Ito, Maryam Zare Jeddi, Marike Kolossa‐Gehring, Eva Kumar, Judy S. LaKind, Marta Esteban, Henriqueta Louro, Kristin Macey, Konstantinos C. Makris, Lisa Jo Melnyk, Aline Murawski, Josh Naiman, Julianne Nassif, Nolwenn Noisel, Devika Poddalgoda, Lesliam Quirós-Alcalá, Ata Rafiee, Loïc Rambaud, Maria João Silva, Jun Ueyama, Marc-André Verner, Maisarah Nasution Waras, Kate Werry,

Human biomonitoring (HBM) data measured in specific contexts or populations provide information for comparing population exposures. There are numerous health-based biomonitoring guidance values, but to locate these values, interested parties need to seek them out individually from publications, governmental reports, websites and other sources. Until now, there has been no central, international repository for this information. Thus, a tool is needed to help researchers, public health professionals, ...

Tópico(s): Toxic Organic Pollutants Impact

2022 - Elsevier BV | International Journal of Hygiene and Environmental Health

Artigo Acesso aberto

Shoji Takakura, Teruo Susumu, Hisashi Satoh, Jo Mori, Akihiko Shiino, Jyoji Handa,

The effects of nilvadipine, a dihydropyridine type calcium channel blocker, on cerebral infarction induced by focal brain ischemia was studied in rats. The area of infarction was measured 24 hr after occlusion of the middle cerebral artery (MCA) in spontaneously hypertensive rats using triphenyltetrazolium chloride. Nilvadipine, given immediately after MCA occlusion, reduced the area of infarction significantly at doses of 0.32 mg/kg (i.p.) and 3.2, 10 and 32 mg/kg (p.o.). Nicardipine suppressed the ...

Tópico(s): Molecular Sensors and Ion Detection

1991 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology

Revisão Revisado por pares

Panayiotis J. Papagelopoulos, F H Sim,

... Clin Orthop. 1988;226:34-37. Google Scholar16. Shoji H, Solomonow M, Yoshino S, D'Ambrosia R, Dabezies E. Factors affecting postoperative flexion in total knee arthroplasty, Orthopedics. 1990; 13:643-649. Google Scholar17. Andriacchi TP, Galante JO. Retention of the posterior cruciate in total knee ...

Tópico(s): Orthopedic Infections and Treatments

1997 - Slack Incorporated (United States) | Orthopedics

Artigo Revisado por pares

Byeongwook Jo, Yuya Morimoto, Shoji Takeuchi,

In recent years, microfluidic systems have been extensively utilized for biological analysis. The integration of pumps in microfluidic systems requires precise control of liquids and effort-intensive set-ups for multiplexed experiments. In this study, a 3D-printed centrifugal pump driven by magnetic force is presented for microfluidics and biological analysis. The permanent magnets implemented in the centrifugal pump synchronized the rotation of the driving and operating parts. Precise control of ...

Tópico(s): Electrohydrodynamics and Fluid Dynamics

2022 - Wiley | Advanced Healthcare Materials

Revisão Acesso aberto Revisado por pares

Jürgen Gröll, Jason A. Burdick, D. W. Cho, Brian Derby, Michael Gelinsky, Sarah C. Heilshorn, Tomasz Jüngst, Jos Malda, Vladimir Mironov, Koichi Nakayama, Aleksandr Ovsianikov, Wei Sun, Shoji Takeuchi, James J. Yoo, Tim B. F. Woodfield,

Biofabrication aims to fabricate biologically functional products through bioprinting or bioassembly (Groll et al 2016 Biofabrication 8 013001). In biofabrication processes, cells are positioned at defined coordinates in three-dimensional space using automated and computer controlled techniques (Moroni et al 2018 Trends Biotechnol. 36 384-402), usually with the aid of biomaterials that are either (i) directly processed with the cells as suspensions/dispersions, (ii) deposited simultaneously in a separate ...

Tópico(s): Cell Image Analysis Techniques

2018 - IOP Publishing | Biofabrication

Revisão Acesso aberto Revisado por pares

Lorenzo Moroni, Thomas Boland, Jason A. Burdick, Carmelo De Maria, Brian Derby, Gabor Forgács, Jürgen Gröll, Qing Li, Jos Malda, Vladimir Mironov, Carlos Mota, Makoto Nakamura, Wenmiao Shu, Shoji Takeuchi, Tim B. F. Woodfield, Tao Xu, James J. Yoo, Giovanni Vozzi,

Biofabrication holds great potential in the fields of regenerative medicine and physiological 3D in vitro models by allowing the manufacture of complex tissue constructs with a higher degree of biomimicry to native tissues than do current biomedical solutions. As the number of biofabrication technologies being developed continues to expand, it is of paramount importance to adopt a concerted terminology framework and avoid generalizations. The ratio between the spatial resolution and the timescale ...

Tópico(s): Anatomy and Medical Technology

2017 - Elsevier BV | Trends in biotechnology

Artigo Revisado por pares

Atsushi Seichi, Atsushi Kimura, Shin‐ichi Konno, Shoji Yabuki,

Tópico(s): Connective tissue disorders research

2016 - Elsevier BV | Journal of Orthopaedic Science