T. OGURI, Takayuki Shioiri, Shun‐ichi Yamada,
The Schiff base (I) from glycine tert-butyl ester and benzaldehyde was treated with lithium diisopropylamide to give the corresponding α-carbanion. Alkylation of the α-carbanion with benzyl or butyl halide followed by removal of benzylidene group yielded phenylalanine or norleucine tert-butyl ester (IIa or IIb), accompanied by dialkylated product (IIIa or IIIb). The Schiff base (IV) from alanine tert-butyl ester and (-)-men-thone (VI) was also treated as above to furnish α-methylphenylalanine or α-methyl- ...
Tópico(s): Chemical Reaction Mechanisms
1977 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
T. OGURI, Takayuki Shioiri, Shun‐ichi Yamada,
Amination of α-lithiated carboxylic acid salts was investigated using isovaleric acid mainly. Methoxyamine bearing a proper electronic character was the best aminating reagent, as shown in Table I. Several α-amino acids, e.g., valine, leucine, methionine, phenylalanine, and α-phenylglycine, were prepared by this new method, summarized in Table II. The synthesis of two new aminating reagents, 3, 5-dinitromesitoxyamine and 2-tetrahydropyranyloxyamine were described.
Tópico(s): Chemical Synthesis and Analysis
1975 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Masaki Shinoda, Katsuhiko Iseki, T. OGURI, Yosio Hayasi, Shun‐ichi Yamada, Masakatsu Shibasaki,
A new prostacyclin analog, 4,4,5,5-tetradehydro-9(0)-methano-gD6(9α)-PGI, has been synthesized by utilizing the regiocontrolled cleavage of the β-propiolactone uith the dialkylaluminum acetylide.
Tópico(s): Carbohydrate Chemistry and Synthesis
1986 - Elsevier BV | Tetrahedron Letters
T. OGURI, Nobutaka Kawai, Takayuki Shioiri, Shun‐ichi Yamada,
An efficient asymmetric synthesis of D-α-amino acid derivatives (VI) has been achieved by alkylation of the Schiff base (III), prepared from glycine tert-butyl ester and (1S, 2S, 5S)-2-hydroxypinan-3-one (II), followed by hydrolytic cleavage of the alkylated Schiff base (V). The chiral source (II) was also recovered in good yield, allowing the proliferation of the asymmetry according to the cycle of the amino acid asymmetric synthesis shown in Chart 1.
Tópico(s): Carbohydrate Chemistry and Synthesis
1978 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
T. OGURI, Takayuki Shioiri, Shun‐ichi Yamada,
N, N-Diethyl phenylacetamide and N-n-butyl phenylacetamide were respectively α-lithiated, followed by amination with methoxyamine to give α-phenylglycine N, N-diethylamide (IVa) and α-phenylglycine N-n-butylamide (IVc). However, phenylacetamide gave phenylglyoxylamide only and tert-butyl phenylacetate did not undergo the above amination reaction. Benzylisocyanide and N-(diphenylmethylene) benzylamine (VII) were respectively α-lithiated, subjected to carboxylation, followed by acid hydrolysis to give ...
Tópico(s): Carbohydrate Chemistry and Synthesis
1975 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Shun‐ichi Yamada, T. OGURI, Takayuki Shioiri,
S. Yamada, T. Oguri and T. Shioiri, J. Chem. Soc., Chem. Commun., 1972, 623a DOI: 10.1039/C3972000623A
Tópico(s): Chemical Synthesis and Analysis
1972 - Royal Society of Chemistry | Journal of the Chemical Society Chemical Communications
Nobutaka Kobayashi, Seiji Miyoshi, Takahide Mikami, Hiroshi Koyama, Masato Kitazawa, Michiko Takeoka, Kenji Sano, Jun Amano, Zenzo Isogai, Shumpei Niida, Kayoko Oguri, Minoru Okayama, John A. McDonald, Koji Kimata, Shun’ichiro Taniguchi, Naoki Itano,
Despite the importance of stromal cells in tumor progression, our overall understanding of the molecular signals that regulate the complex cellular interactions within tumor stroma is limited. Here, we provide multiple lines of evidence that tumor-associated macrophages (TAM) preferentially traffic to stromal areas formed within tumors in a manner dependent on a hyaluronan (HA)-rich tumor microenvironment. To address the role of stroma-derived HA in macrophage recruitment, we disrupted the HA synthase ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2010 - American Association for Cancer Research | Cancer Research
Takuya Kanai, Yumiko Senoo, Kota Asaka, Jun Sugawa, Hideaki Tamai, Hiroyuki Saito, Naoki Minato, Atsushi Oguri, Seiya Sumita, Takehiro Sato, Nobuhiko Kikuchi, Shun-ichi Matsushita, Takehiro Tsuritani, Satoru Okamoto, Naoaki Yamanaka, Ken-Ichi Suzuki, Akihiro Otaka,
This paper shows the concept of the elastic lambda aggregation network (EλAN) that will achieve an elastic common access infrastructure for the metro-access network. It proposes a service restoration technique that uses optical path switching and intercentral office handover for EλAN to recover from disasters. The feasibility of the proposed service restoration technique is successfully demonstrated for the first time by using a prototype testbed of a metro-access network. By applying both orthogonal ...
Tópico(s): Optical Network Technologies
2018 - Institute of Electrical and Electronics Engineers | Journal of Lightwave Technology
... statements along these lines. In 1908, for instance, Oguri Fūyō, Yanagawa Shun'yō, Tokuda Shūkō, Ikuta Chōkō, and Mayama Seika ...
Tópico(s): Translation Studies and Practices
2007 - Sophia University | Monumenta Nipponica
Karunakar Reddy Bonepally, Takahisa Hiruma, Haruki Mizoguchi, Kyohei Ochiai, Shun Suzuki, Hideaki Oikawa, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Ōmura, Hiroki Oguri,
Development of designer natural product variants, 6-aza-artemisinins, enabled us to achieve structural modification of the hitherto unexplored cyclohexane moiety of artemisinin and concise de novo synthesis of the tetracyclic scaffold in just four steps from the modular assembly of three simple building blocks. This expeditious catalytic asymmetric synthetic approach generated lead candidates exhibiting superior in vivo antimalarial activities to artemisinin.
Tópico(s): Malaria Research and Control
2018 - American Chemical Society | Organic Letters
Yuiki Kuramoto, Yuki KAWAMOTO, Takumi OGURI, Shun Takahashi, Masayuki OCHIAI, Akihiko AZETSU, Kenji Yamamoto,
Post-injection is a technology to reduce emissions of diesel particulate substance by the small amount of fuel injection after the main injection. However, fuel adhering to bore wall mixes into oil and loss of lubrication performance. We predicted the transport of diluted fuel around the piston ring and developed the three-phase flow simulation code considered air, fuel, and oil. We compared the behavior of two phase, three phase and experiment by liquid sloshing for the validation. The frequency ...
Tópico(s): Oil and Gas Production Techniques
2018 - The Japan Society of Mechanical Engineers | Keisan Rikigaku Koenkai koen ronbunshu/Keisan Rikigaku Kouenkai kouen rombunshuu
Yoshio Takesue, Akira Watanabe, Shinya Kusachi, Tetsuro Matsumoto, Aikichi Iwamoto, Kyoichi Totsuka, Keisuke Sunakawa, Morimasa Yagisawa, Junko Sato, Toyoko Oguri, Kunio Nakanishi, Yoshio Takesue, Yoshio Takesue, Hideaki Hanaki, Shinya Kusachi, Yoshinobu Sumiyama, Yuko Kitagawa, Yoshinobu Sumiyama, Yuko Kitagawa, Go Wakabayashi, Isamu Koyama, Katsuhiko Yanaga, Toshiro Konishi, Ryoji Fukushima, Shiko Seki, Shun Imai, Tsunehiro Shintani, Hiroki Tsukada, Kazuhiro Tsukada, Kenji Omura, Hiroshige Mikamo, Hiromitsu Takeyama, Masato Kusunoki, Shoji Kubo, Junzo Shimizu, Toshihiro Hirai, Hiroki Ohge, Akio Kadowaki, Kohji Okamoto, Katsunori Yanagihara,
To investigate the trends of antimicrobial resistance in pathogens isolated from surgical site infections (SSI), a Japanese surveillance committee conducted the first nationwide survey. Seven main organisms were collected from SSI at 27 medical centers in 2010 and were shipped to a central laboratory for antimicrobial susceptibility testing. A total of 702 isolates from 586 patients with SSI were included. Staphylococcus aureus (20.4 %) and Enterococcus faecalis (19.5 %) were the most common isolates, followed ...
Tópico(s): Antibiotic Use and Resistance
2012 - Elsevier BV | Journal of Infection and Chemotherapy
Karunakar Reddy Bonepally, Norihito Takahashi, Naoya Matsuoka, H. Koi, Haruki Mizoguchi, Takahisa Hiruma, Kyohei Ochiai, Shun Suzuki, Yutaka Yamagishi, Hideaki Oikawa, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi O̅mura, Nobutaka Kato, Hiroki Oguri,
To achieve both structural changes and rapid synthesis of the tetracyclic scaffold relevant to artemisinins, we explored two kinds of de novo synthetic approaches that generate both skeletally diversified tetracyclic peroxides and 6-aza-artemisinins. The anti-malarial activities of the tetracyclic peroxides with distinct skeletal arrays, however, were moderate and far inferior to artemisinins. Given the privileged scaffold of artemisinins, we next envisioned element implantation at the C6 position ...
Tópico(s): Computational Drug Discovery Methods
2020 - American Chemical Society | The Journal of Organic Chemistry
Hiroyuki Ogawa, Ryota Koyanagi, E. Kawada-Watanabe, Junji Yamaguchi, Akihiko Takagi, Nobutoshi Hagiwara, P. Deedwania, D. A. Demicco, A. Breazna, C. C. Wun, Thomas Garm Pedersen, Helen M. Colhoun, Andrew Neil, G. A. Hitman, K. Nakanishi, Shinsaku Fukuda, Kenji Shimada, S. Ehara, H. Inanami, Kunio Matsumoto, Hirokuni Taguchi, Takahiro Muro, Jun Yoshikawa, M. Yoshiyama, Kyriakos Dimitriadis, Costas Tsioufis, I. Tatsis, G. Chlapoutakis, L. Lioni, V. Tzamou, Alexandros Kasiakogias, C. Thomopoulos, Dimitris Tousoulis, Christodoulos Stefanadis, D. Terentes-Printzios, Charalambos Vlachopoulos, K. Aznaouridis, Nikolaos Ioakeimidis, Christodoulos Stefanadis, Biljana Parapid, Vladan Vukčević, Biljana Obrenović-Kirćanski, Dunja Šimić, N. M. Milic, V. Stojanov, B. Beleslin, I. Nedeljkovic, O. M. S. Nedeljkovic-Arsenovic, M. C. Ostojic, Dipak Kotecha, Henry Krum, Gishel New, D. Eccleston, Paul Collins, Marcus Flather, Jon Paul Pepper, Hirofumi Tomiyama, Masanori Odaira, M Yoshida, Kazuhiro Shiina, Cal Matsumoto, A. Yamashina, Luigi Emilio Pastormerlo, S. Maffei, Vladyslav Chubuchny, A. Mazzone, C. Susini, Claudio Passino, D. Chiappino, Michele Emdin, Aldo Clerico, Vasiliki Katsi, George Souretis, I. Vlasseros, Dimitrios A. Vrachatis, Dimitris Tousoulis, Christodoulos Stefanadis, Ioannis Kallikazaros, Emmanuel Androulakis, Dimitris Tousoulis, E. Chatzistamatiou, N. Papageorgiou, A. Miliou, Charalambos Vlachopoulos, Gerasimos Siasos, G. Moustakas, Ioannis Kallikazaros, Christodoulos Stefanadis, Juan Eugenio Ochoa, J. K. Balparda, Margarete Correa, A. M. Valencia, Mora Álvarez, Jill McEwen, Grzegorz Bilo, Pier Federico Salvi, D. Aristizabal, Gianfranco Parati, H. de Vries, Mariëtte M van Engen-Verheul, Hareld Kemps, Roderik A. Kraaijenhagen, Naomi Peek, P. L. Vervueren, Vanina Bongard, Dominique Arveiler, Jean Dallongeville, J. B. Ruidavets, Andrew Wagner, Philippe Amouyel, Amie Bingham, Meyer Elbaz, Jean Ferrières, K Kamiya, Alessandro Mezzani, Kaori Hotta, Masahiro Tabata, Chieri Noda, K. Ohori, T Inomata, Minako Yamaoka‐Tojo, Akira Matsunaga, T Masuda, Ignacio Rangel, Aline Rocha, C. Sousa, A. Sousa, Adriana Sales Cunha Correia, M. Paiva, F. Melao, V. Araujo, F. Parada-Pereira, M. J. Maciel, Ekaterina A. Kolesnikova, G. P. Arutyunov, A. K. Rylova, N. V. Rylova, V. I. Lobzeva, T. Chwyczko, Edyta Smolis‐Bąk, Roman Dąbrowski, Maciej Sterliński, Aleksander Maciąg, Agnieszka Borowiec, Ilona Kowalik, Mariusz Pytkowski, Hanna Szwed, Guido Claessen, André La Gerche, Alexander Van De Bruaene, Marc Gewillig, Steven Dymarkowski, P. Claus, Hein Heidbüchel, Erik Skobel, Christian Knackstedt, A. Martinez Romero, B. Scheibe-Schmidt, Patrick Schauerte, Miodrag Ilić, S. Ilic, G. Kocic, Radisa R Pavlovic, V. Stoickov, V. Ilic, Adriana Sales Cunha Correia, A. Goncalves, Aline Rocha, Susy Costa, Felipe De Souza Guilherme, M. Paiva, A. Sousa, V. Araujo, F. P. Pereira, M. J. Maciel, T. Matsumoto, Masatoshi Fujita, Hiroaki Hayashi, Ichiro Nakae, Mai Horie, Robin Olsen, T. Monk-Hansen, C. Couppe, U. R. Mikkelsen, Anne‐Gerd Karlsen, Chris Dall, Patrik K. E. Magnusson, Eva Prescott, Adam R. Szymanowski, Lise-Lotte Nilsson, Eva Swahn, Lise‐Lotte Jonasson, M. Mutuberria, Antonia Sambola, J. Francisco Pascual, Joan Figueras, Bruno García del Blanco, Gutiérrez Martí, M. Ruiz-Meana, Imanol Otaegui, J. Barrabes, D. Garcia-Dorado, Magdalena Polańska-Skrzypczyk, Maciej Karcz, P. Bekta, C. Kepka, J. Przyluski, M. Kruk, E. Ksiezycka, A. Ciszewski, Adam Witkowski, Witold Rużyłło, T. Kellerth, V. Liakopoulos, K. C. Christensen, Mohd Farman, S. Tahir, S. Nadeem Hasan Rizvi, K. Naveedullah, S. Jawaid Akbar, D. I. Bromage, Krishnaraj S. Rathod, Danielle Jones, Rahul Sen, JitendraN Patel, A. Jain, Charles H. Knight, A. Mathur, A. Wragg, A. Shirakabe, Nobuhiro Hata, Norikazu Kobayashi, T. Shinada, Kaori Tomita, Masashi Tsurumi, Marcus Matsushita, Takako Shimura, K Asai, Kentaro Mizuno, Holger Woehrle, Michael Arzt, Olaf Oldenburg, Erland Erdmann, Helmut Teschler, Andrea Graml, Karl Wegscheider, B. Krakowiak, Marzena Olesińska, B. Paleczny, Kamila Ludwikowska, Waldemar Banasiak, Piotr Ponikowski, Ewa A. Jankowska, Marco Antônio, Josep Lupón, Jorge Comín, A. Galán, Beatríz González, L. Cano, R. Cabanes, Amaia Urrutia, Elisabet Zamora, Antoni Bayés‐Genís, Luigi Emilio Pastormerlo, C. Mammini, A. Gabutti, R Poletti, G. Mirizzi, S. Chiappino, Claudio Passino, Michele Emdin, S. Taillandier, Laurent Fauchier, B. Lallemand, N. Clementy, A. Bernard, B. Pierre, Edward Niño John Simeon, S. Taillandier, Dominique Babuty, V. Shumaviec, Y. Ostrovski, A. Shket, A. Janushko, A. Lysjonok, O. Jdanovich, A. Beresneva, V. Shumaviec, Y. Ostrovski, N. Moroz-Vodolajskaja, S. Kurganovich, Nina Konstantinovna Semenova, I. Grinchuk, A. Shket, A. Janushko, Kenji Kuwaki,
Oxford University Press